Koyano Shigeru 児矢野繁

… Alternative Names

KOYANO Shigeru 児矢野繁

児矢野繁コヤノシゲル

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Researcher Number	50315818
Other IDs
Affiliation (Current)	2022: 横浜市立大学, 医学研究科, 客員教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 横浜市立大学, 医学研究科, 客員教授 2011 – 2016: 横浜市立大学, 医学部, 准教授 2009: 横浜市立大学, 医学研究科, 准教授 2007: Yokohama City University, Graduate School of Medical Sciences, Assistant Professor 2005 – 2006: 横浜市立大学, 医学部, 準教授 2004: 横浜市立大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology / Metabolomics / Nerve anatomy/Neuropathology
Keywords	Principal Investigator ポリグルタミン病 / 筋萎縮性側索硬化症 / 脊髄小脳変性症 / TDP-43 / ATXN / 脳神経疾患 / カルシウムシグナリング / カルシウムチャネル / 多系統萎縮症 / 尿酸 / 酸化ストレス / 尿酸トランスポーター / 活性酸素 … More Except Principal Investigator … More ポリグルタミン病 / パーキンソン病 / 選択的視覚注意課題 / 分配的視覚注意課題 / ALS / 脳神経疾患 / 神経科学 / oddball課題 / S1-S2課題 / 視覚誘発電位(P1) / 視覚性事象関連電位(P3) / 錯視刺激 / 立体視刺激 / UBQLN2 / ビタミンB1欠乏 / ヘリコパクター・ピロリ菌感染 / ヘリコバクター・ピロリ菌感染 / PCBP / RNA結合タンパク / 核内封入体 / 事象関連電位 / ポジトロン断層撮影 / 多系統萎縮症 / 大脳皮質基底核変性症 / 進行性核上性麻痺 / 脳血流 / 脳代謝 / 視覚注意課題 / 高次脳機能 / 認知症 / 視覚性事象関連電位 / 立体的錯視課題 / 回転錯視課題 / 潜時 / 振幅 / 手指反応時間 / event related potentials / positron emission tomography / multiple sytem atrophy / corticobasal degeneration / progressive supranuclear palsy / cerebral blood flow / cerebral metabolism / visual attention paradigm / 脊髄小脳変性症 / 運動解析 / 小脳性運動失調 / 3次元動作解析 / 3次元解析 / 動作解析 / matrin3 / polyglutamine / FTLD / TDP43 / MATR3 / SALS / 仮面様顔貌 / Parkinson / amimia / 記憶 / 情動 / 表情 / 認知機能 / MRI / 脳・神経 / 臨床 Less

Study of pathogenesis caused by hypouricemia in multiple system atrophyPrincipal Investigator
- Principal Investigator
  
  KOYANO Shigeru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Development of objective evaluation method of cerebellar ataxia using 3D motion analysis system
- Principal Investigator
  
  Ueda Naohisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Neural substrates of masked-face in Parkinson disease: A quantitative analysis of facial expression.
- Principal Investigator
  
  Yuichi HIGASHIYAMA
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Analysis of polyglutamine aggregation protein in ALS/FTLD
- Principal Investigator
  
  TADA Mikiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Yokohama City University
Calcium-signaling abnormality of polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  KOYANO Shigeru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Analysis of RNA binding proteins in polyglutamine disease
- Principal Investigator
  
  TANAKA Fumiaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Integrated research of polyglutamine disease and ALS/FTLD by analysis of UBQLN2
- Principal Investigator
  
  TANAKA Fumiaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Analysis of patient factors in latent vitamin B1 deficiency
- Principal Investigator
  
  HIRATA Jun-ichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
Common coupling protein of amyotrophic lateral sclerosis and spinocerebellar degenerationPrincipal Investigator
- Principal Investigator
  
  KOYANO Shigeru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Integrated Functional Tests of Sensory-Emotional-Autonomic System Using Multimodality Visual Stimulation
- Principal Investigator
  
  KUROIWA Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University
Production of quantitative higher brain function assessing system using visual event related potentials and positron emission tomography
- Principal Investigator
  
  KUROIWA Yoshiyuki
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Yokohama City University

All 2019 2017 2016 2015 2014 2013 2012 2011 2010 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 第9章神経・筋の疾患 4 てんかん, ファーマシューティカルケアファーストステップ2007
- Author(s)
  児矢野繁, 黒岩義之
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-16590838
[Journal Article] Neuropathological Staging of Spinocerebellar Ataxia Type 2 by Semiquantitative 1C2-Positive Neuron Typing. Nuclear Translocation of Cytoplasmic 1C2 Underlies Disease Progression of Spinocerebellar Ataxia Type 22014
- Author(s)
  Koyano S, Yagishita S, Kuroiwa Y, Tanaka F, Uchihara T.
- Journal Title
  
  Brain pathology
  
  Volume: 26 Pages: 599-606
- DOI
  10.1111/bpa.12146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591279, KAKENHI-PROJECT-25293207, KAKENHI-PROJECT-25430057, KAKENHI-PROJECT-26670445
[Journal Article] Mutations of COQ2 in familial and sporadic multiple system atrophy.2013
- Author(s)
  Mitsui J, et. al.
- Journal Title
  
  New Engl J Med
  
  Volume: 369 Pages: 233-244
- DOI
  10.1056/nejmoa1212115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02422, KAKENHI-PLANNED-22129002, KAKENHI-PLANNED-22129004, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-23591269, KAKENHI-PROJECT-23591279, KAKENHI-PROJECT-24390220, KAKENHI-PUBLICLY-25110720, KAKENHI-PROJECT-25670420, KAKENHI-PROJECT-25713015, KAKENHI-PROJECT-25860700, KAKENHI-PROJECT-221S0002
[Journal Article] Homozygous c.14576G>A variant of RNF213 predicts early-onset and severe form of moyamoya disease2012
- Author(s)
  Miyatake S, Miyake N, Touho H, Nishimura-T, A, Kondo Y, Okada ; I, Tsurusaki ; Y, Doi H, Sakai H, Saitsu ; H, Shimojima K, Yamamoto T, Higurashi M, Kawahara, N, Kawauchi, H, Nagasaka, K, Okamoto N, Mori, T, Koyano S, Kuroiwa Y, Taguri M, Morita S, Matsuba S, Kure S, Matsumoto N
- Journal Title
  
  Neurology
  
  Volume: 78(11) Pages: 803-10
- DOI
  10.1212/wnl.0b013e318249f71f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117, KAKENHI-PROJECT-21591334, KAKENHI-PROJECT-22790823, KAKENHI-PROJECT-22890199, KAKENHI-PUBLICLY-23110534, KAKENHI-PROJECT-23390267, KAKENHI-PROJECT-23390268, KAKENHI-PROJECT-23659512, KAKENHI-PROJECT-23659513, KAKENHI-PROJECT-23689052, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24659486, KAKENHI-ORGANIZER-24118001
[Journal Article] Modulation of human visual evoked potentials in three-dimensional perception after stimuli produced with an integral imaging method2012
- Author(s)
  Omoto S, Kuroiwa Y, Otsuka S, Baba Y, Wang C, Li M, Mizuki N, Ueda N, Koyano S, Suzuki Y, Nagatani H, Hirayama Y
- Journal Title
  
  Clinical EEG and Neuroscience
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117
[Journal Article] Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation2011
- Author(s)
  Doi H, Yoshida K, Yasuda T, Fukuda M, Morita R, Ikeda S, Kato R, Tsurusaki Y, Miyake N, Saitsu H, Sakai H, Miyatake S, Shiina M, Nukina N, Koyano S, Tsuji S, Kuroiwa Y, Matsumoto N
- Journal Title
  
  Am J Hum Genet
  
  Volume: 89(2) Pages: 320-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117
[Journal Article] P1and P2componentsof human visual evoked potentials are modulated by depth perception of 3-dimensional images2010
- Author(s)
  Omoto S, Kuroiwa Y, Otsuka S, Baba Y, Wang C, Li M, Mizuki N, Ueda N, Koyano S, Suzuki Y
- Journal Title
  
  Clinical Neurophysiology
  
  Volume: 121 Pages: 386-391
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117
[Journal Article] The RNA-binding protein FUS/TLS is a common aggregateinteractingprotein in polyglutamine diseases2010
- Author(s)
  Doi H, Koyano S, Suzuki Y, Nukina N, Kuroiwa Y
- Journal Title
  
  NeurosciRes
  
  Volume: 66 Pages: 131-133
- DOI
  10.1016/j.neures.2009.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117
[Journal Article] Siblings with the adult-onset slowly progressive type of pantothenate kinase-associated neurodegeneration and anovel mutation, Ile346Ser, in PANK2 : clinical featuresand(99m) Tc-ECD brain perfusion SPECT findings2010
- Author(s)
  Doi H, Koyano S, Miyatake S, Matsumoto N, Kameda T, Tomita A, Miyaji Y, Suzuki Y, Sawaishi Y, Kuroiwa Y
- Journal Title
  
  JNeurol Sci
  
  Volume: 290 Pages: 172-176
- DOI
  10.1016/j.jns.2009.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591117
[Journal Article] Electrophysiologicalanalysis of Myerson sign in Parkinson's disease2010
- Author(s)
  Uematsu E, Kishida H, Nakano T, Iwahashi Y, Ueda N, Koyano S, Suzuki Y, Kuroiwa Y
- Journal Title
  
  Journal of Neurology
  
  Volume: 257
- Data Source
  KAKENHI-PROJECT-21591117
[Journal Article] パーキンソン症状を伴うSpinocerebellar ataxia type22007
- Author(s)
  児矢野繁, 馬場泰尚, 黒岩義之
- Journal Title
  
  The Journal of Disorder and Disability運動障害 17(2)
  
  Pages: 43-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590838
[Journal Article] Visual evoked potentials in Creutzfeldt-Jakob disease.2006
- Author(s)
  Koyano S, Toda H, Kuroiwa Y
- Journal Title
  
  The 14th Biennial Congress of International Pharmaco-EEG Society Training Course/Symposium Abstracts 14-1
  
  Pages: 17-17
- Data Source
  KAKENHI-PROJECT-16590838
[Journal Article] Visual evoked potentials in Machado-Joseph disease (MJD/SCA3).2006
- Author(s)
  Baba Y, Koyano S, Suzuki Y, Kuroiwa Y
- Journal Title
  
  The 14th Biennial Congress of International Pharmaco-EEG Society Training Course/Symposium Abstracts 14-1
  
  Pages: 70-70
- Data Source
  KAKENHI-PROJECT-16590838
[Journal Article] Visual event-related potentials under different interstimulus intervals in Parkinson's disease: relation to motor disability, WAIS-R, and regional cerebral blood flow2005
- Author(s)
  Li, M., Kuroiwa, Y., Takahashi, T., Suzuki, Y., Koyano, S., Ikegami, T., Matsubara, S
- Journal Title
  
  Parkinsonism and Related Disorders 11(4)
  
  Pages: 209-219
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590838
[Journal Article] Visual evoked potential changes related to illusory perception in normal human subjects2004
- Author(s)
  Hayashi, E., Kuroiwa, Y., Omoto, S., Kamitani, T., Li, M., Koyano, S
- Journal Title
  
  Neurosci Lett.8 359, (1-2)
  
  Pages: 29-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590838
[Presentation] PLA2G6-associated neurodegeneration with eye-of-the-tiger sign on MRI in siblings2019
- Author(s)
  児矢野　繁
- Organizer
  日本神経学会総会
- Data Source
  KAKENHI-PROJECT-17K09805
[Presentation] 四肢筋力低下で発症したMcLeod症候群の55歳男性例2017
- Author(s)
  多賀須むつき,古宮裕泰,多田美紀子,植松絵里,田中健一,上木英人,児矢野繁,田中章景
- Organizer
  第220回日本神経学会関東・甲信越地方会
- Place of Presentation
  砂防会館（東京都）
- Year and Date
  2017-03-04
- Data Source
  KAKENHI-PROJECT-15K18367
[Presentation] IgG4関連ニューロパチーと鑑別を要した家族性アミロイドポリニューロパチー(ATTR-FAP)の71歳男性例2016
- Author(s)
  古宮裕泰, 多田美紀子, 石戸淳一, 多賀須むつき, 田中健一, 上木英人, 児矢野繁, 田中章景
- Organizer
  第218回日本神経学会関東・甲信越地方会
- Place of Presentation
  砂防会館（東京都）
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-15K18367
[Presentation] 多系統萎縮症と尿酸との関連（病型別の検討）2016
- Author(s)
  児矢野繁、上田直久，東山雄一，上木英人，岸田日帯，木村活生，齋藤麻美，中江啓晴，釘本千春，土井宏，田中章景
- Organizer
  第57回神経学会総会
- Place of Presentation
  神戸コンベンションセンター神戸国際会議場（兵庫県）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461315
[Presentation] RNF213多型を認め、中大脳動脈領域に広範囲の脳梗塞を生じた39歳男性例2016
- Author(s)
  浅野敬一郎, 三宅綾子, 中江啓晴, 田中健一, 多田美紀子, 土井宏, 児矢野繁, 田中章景
- Organizer
  第217回日本神経学会関東・甲信越地方会
- Place of Presentation
  砂防会館（東京都）
- Year and Date
  2016-06-04
- Data Source
  KAKENHI-PROJECT-15K18367
[Presentation] SCA2病変におけるTDP-43細胞内局在2015
- Author(s)
  児矢野繁、多田美紀子、柳下三郎、内原俊記，田中章景
- Organizer
  第56回日本神経病理学会総会
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市東区）
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-25293207
[Presentation] 孤発性筋萎縮性側索硬化症におけるMatrin3の病理学的検討2015
- Author(s)
  多田美紀子、土井宏、児矢野繁、田中章景
- Organizer
  第56回日本神経病理学会総会
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市東区）
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-25293207
[Presentation] SCA2病変におけるTDP-43細胞内局在2015
- Author(s)
  児矢野繁、多田美紀子、柳下三郎、内原俊記、田中章景
- Organizer
  第56回日本神経病理学会総会
- Place of Presentation
  九州大学医学部百年講堂(福岡県福岡市東区)
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-26670445
[Presentation] Matrin 3 is a component of neuronal cytoplasmic inclusion of motor neuron in SALS2015
- Author(s)
  Mikiko Tada, Hiroshi Doi, Shigeru Koyano, Fumiaki Tanaka
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K18367
[Presentation] 孤発性筋萎縮性側索硬化症におけるMatrin3の病理学的検討2015
- Author(s)
  多田美紀子、土井宏、児矢野繁、田中章景
- Organizer
  第56回日本神経病理学会総会
- Place of Presentation
  九州大学医学部百年講堂(福岡県福岡市東区)
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-26670445
[Presentation] 孤発性筋萎縮性側索硬化症におけるMatrin3の病理学的検討2015
- Author(s)
  多田美紀子,土井宏,児矢野繁,田中章景
- Organizer
  第56回日本神経病理学会総会
- Place of Presentation
  九州大学医学部百年講堂（福岡県福岡市）
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-15K18367
[Presentation] 多系統萎縮症と尿酸との関連性2013
- Author(s)
  児矢野繁、鈴木ゆめ、田中章景
- Organizer
  第54回神経学会総会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23591279
[Presentation] 視覚誘発電位の特徴に関する研究:二次元刺激と三次元刺激の比較2011
- Author(s)
  黒岩義之, 尾本周, 馬場泰尚, 児矢野繁, 鈴木ゆめ
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21591117
[Presentation] SCA2とALSにおける共通結合蛋白(TDP-43とATXN2)2011
- Author(s)
  児矢野繁、黒岩義之、柳下三郎、内原俊記
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-18
- Data Source
  KAKENHI-PROJECT-23591279
[Presentation] Clinical and neuroimaging study in an overlap case of PD and FTD2007
- Author(s)
  Baba, Y., Kimura, K., Hakii, Y., Iwahashi, Y., Seino, U., Kishida, H., Nishiyama, T., Kugimoto, C., Koyano, S., Suzuki, Y., Endo, M., Toda, H., Takahashi, T., Kuroiwa, Y
- Organizer
  The International Conference AD/PD2007
- Place of Presentation
  Salzburg
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590838
[Presentation] Visual evoked potentials in Machado-Joseph disease2006
- Author(s)
  Baba, Y., Koyano, S., Suzuki, Y., Kuroiwa, Y
- Organizer
  The 14th iennial Congress of International Pharmaco-EEG Society Symposium
- Place of Presentation
  Hyogo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590838
[Presentation] Visual evoked potentials in Creutfeldt-Jakob disease2006
- Author(s)
  Koyano, S., Toda, H., Kuroiwa, Y
- Organizer
  The 14th iennial Congress of International Pharmaco-EEG Society Symposium
- Place of Presentation
  Hyogo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590838

1. TANAKA Fumiaki (30378012)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. DOI Hiroshi (10326035)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. TADA Mikiko (30722467)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
4. SUZUKI Yume (70236024)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
5. KUROIWA Yoshiyuki (40135249)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
6. Yuichi HIGASHIYAMA (10722449)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TANAKA Ken-ichi (50722881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. NUKINA Nobuyuki (10134595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIRATA Jun-ichi (40347323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAKII Yasuhito (70336543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Ueda Naohisa (00305442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SATAKE Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 辻省次

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 戸田達史

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16. 金井数明

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17. 呉繁夫

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18. 松原洋一

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19. 岡本伸彦

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20. 三宅紀子

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Koyano Shigeru 児矢野 繁

KOYANO Shigeru 児矢野 繁

児矢野 繁 コヤノ シゲル

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Study of pathogenesis caused by hypouricemia in multiple system atrophyPrincipal Investigator

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Calcium-signaling abnormality of polyglutamine diseasesPrincipal Investigator

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Common coupling protein of amyotrophic lateral sclerosis and spinocerebellar degenerationPrincipal Investigator

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[Book] 第9章 神経・筋の疾患 4 てんかん, ファーマシューティカルケアファーストステップ2007

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[Journal Article] Neuropathological Staging of Spinocerebellar Ataxia Type 2 by Semiquantitative 1C2-Positive Neuron Typing. Nuclear Translocation of Cytoplasmic 1C2 Underlies Disease Progression of Spinocerebellar Ataxia Type 22014

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[Journal Article] Mutations of COQ2 in familial and sporadic multiple system atrophy.2013

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[Journal Article] Homozygous c.14576G>A variant of RNF213 predicts early-onset and severe form of moyamoya disease2012

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Koyano Shigeru 児矢野繁

KOYANO Shigeru 児矢野繁

児矢野繁コヤノシゲル

[Book] 第9章神経・筋の疾患 4 てんかん, ファーマシューティカルケアファーストステップ2007