Tomita Kengo 冨田謙吾

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TOMITA Kengo 冨田謙吾

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Researcher Number	50317129
Other IDs
Affiliation (Current)	2023: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院内科, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院内科, 准教授 2017 – 2018: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院内科, 准教授 2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院内科, 講師 2015: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 講師 2013: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 … More 2011 – 2012: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 助教 2010: 慶應義塾大学, 医学部, 助教 2009 – 2010: 慶応義塾大学, 医学部, 助教 2008 – 2010: Keio University, 医学部, 共同研究員 2007 – 2008: Keio University, School of Medicine, Assistant Professor 2001 – 2006: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 59040:Nutrition science and health science-related / Basic Section 53010:Gastroenterology-related Except Principal Investigator General medical chemistry / Gastroenterology
Keywords	Principal Investigator 非アルコール性脂肪肝炎 / 肝再生 / レチノイン酸 / 脂肪肝 / 脂肪肝炎 / 肝臓癌 / Angiopoietin like protein / 肝線維化 / 肝星細胞 / ACLP … More / 肝細胞 / CRAD2 / レチノール脱水素酵素 / 核内受容体シグナル / RXR / アルコール性肝障害 / レプチン / ピオグリタゾン / PPARgamma / アルコール / c-Met / 酸化ストレス / インスリン抵抗性 / 急性肝障害 / 肝細胞癌 / 内科 / 糖尿病 / シグナル伝達 / 肝臓線維化 / Angptl2 / steatohepatitis / 遊離コレステロール / TLR9 / アセトアミノフェン肝障害 / 類洞内皮細胞 / コレステロール / 細胞老化 / 肥満 / Wnt / 肝臓がん / lipoprotein lipase / β-カテニン / 肝がん … More Except Principal Investigator 加齢 / 酸化ストレス / 脂肪肝 / NASH / モデルマウス / SOD / 肥満 / レプチン / SP細胞 / 幹細胞自家移植療法 / コラーゲンゲルサインドイッチ法 / 肝細胞分化誘導法 / 肝細胞分化 / 脾臓 / 自家細胞移植 / 肝再生 / 細胞融合 / 移植医療 / 肝硬変 / 肝不全 / 初代培養肝細胞 / コラーゲンゲル / 幹細胞 / side population cell / stem cell autotransplantation / collagen gel sandwich configuration / hepatic differentiation induction method Less

過栄養・肥満による臓器線維化の不顕性進展機構の解明と、疾患治療への応用Principal Investigator
- Principal Investigator
  
  冨田謙吾
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Defense Medical College
Elucidation of the pathological mechanism of obesity-related liver cancer and development of the new treatment methods, focusing on secretory factors from hepatic stellate cellsPrincipal Investigator
- Principal Investigator
  
  Tomita Kengo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Defense Medical College
Establishment of novel therapies for steatohepatitis and liver cancer, by targeting the free cholesterol-mediated signaling pathway.Principal Investigator
- Principal Investigator
  
  Tomita Kengo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Defense Medical College
Unraveling the role of Angptl2 in the pathogenesis of steatohepatitis and liver cancerPrincipal Investigator
- Principal Investigator
  
  TOMITA Kengo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Defense Medical College
Molecular mechanism for aging control
- Principal Investigator
  
  SHIRASAWA Takuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Juntendo University
Analysis of the paradoxical correlation between hepatic insulin resistance and oxidative stress in the pathogenesis of steatohepatitisPrincipal Investigator
- Principal Investigator
  
  TOMITA Kengo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Involvement of Angpt14 in the pathological mechanisms of steatosis and steatohepatitisPrincipal Investigator
- Principal Investigator
  
  TOMITA Kengo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
肝細胞の脂肪化におけるレチノイン酸X受容体の役割とその治療応用に関する検討Principal Investigator
- Principal Investigator
  
  冨田謙吾
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Experimental research for treatment of liver failure with hepatic tissue stem cell (SP cell)
- Principal Investigator
  
  HORIE Yoshinori, 石井裕正
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
肝細胞の長期培養系の確立:特にレチノイン酸、ステロイドホルモン代謝の役割についてPrincipal Investigator
- Principal Investigator
  
  冨田謙吾
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 2006 2005 2004

All Journal Article Presentation

[Journal Article] Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor.2019
- Author(s)
  Shirakabe K, Higashiyama M, Furuhashi H, Takajo T, Maruta K, Okada Y, Kurihara C, Watanabe C, Komoto S, Tomita K, Nagao S, Miura S, Saruta M, Hokari R.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 印刷中
- DOI
  10.1111/jgh.14092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07924
[Journal Article] Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.2019
- Author(s)
  Takajo T, Tomita K, Tsuchihashi H, Enomoto S, Tanichi M, Toda H, Okada Y, Furuhashi H, Sugihara N, Wada A, Horiuchi K, Inaba K, Hanawa Y, Shibuya N, Shirakabe K, Higashiyama M, Kurihara C, Watanabe C, Komoto S, Nagao S, Kimura K, Miura S, Shimizu K, Hokari R.
- Journal Title
  
  Gut and Liver
  
  Volume: 印刷中
- DOI
  10.5009/gnl18296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07924
[Journal Article] Nicotine treatment ameliorates DSS-induced colitis by suppressing MAdCAM-1 expression and leukocyte recruitment.2018
- Author(s)
  Maruta K, Watanabe C, Hozumi H, Kurihara C, Furuhashi H, Takajo T, Okada Y, Shirakabe K, Higashiyama M, Komoto S, Tomita K, Nagao S, Ishizuka T, Miura S, Hokari R.
- Journal Title
  
  J Leukoc Biol.
  
  Volume: 104 Pages: 1013-1022
- DOI
  10.1002/jlb.3a0717-304r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01886, KAKENHI-PROJECT-17K09398, KAKENHI-PROJECT-18K11120, KAKENHI-PROJECT-18K07924
[Journal Article] Vitamin A-coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis.2018
- Author(s)
  Furuhashi H, Tomita K, Teratani T, Shimizu M, Nishikawa M, Higashiyama M, Takajo T, Shirakabe K, Maruta K, Okada Y, Kurihara C, Watanabe C, Komoto S, Aosasa S, Nagao S, Yamamoto J, Miura S, Hokari R.
- Journal Title
  
  Hepatol Res.
  
  Volume: 48 Pages: 397-407
- DOI
  10.1111/hepr.13040
- Data Source
  KAKENHI-PROJECT-18K07924
[Journal Article] Aortic carboxypeptidase-Like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis.2018
- Author(s)
  Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S, Minamino T, Oike Y, Hokari R, and Kanai T.
- Journal Title
  
  J Clin Invest.
  
  Volume: 128 Pages: 1581-1596
- DOI
  10.1172/jci92863
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09421, KAKENHI-PLANNED-26115008, KAKENHI-PROJECT-18K08014, KAKENHI-PROJECT-18K07924
[Journal Article] Psychological stress exacerbates NSAID-induced small bowel injury by inducing changes in intestinal microbiota and permeability via glucocorcitoid receptor signaling.2017
- Author(s)
  Yoshikawa K, Kurihara C, Furuhashi H, Takajo T, Maruta K, Yasutake Y, Sato H, Narimatsu K, Okada Y, Higashiyama M, Watanabe C, Komoto S, Tomita K, Nagao S, Miura S, Tajiri H, Hokari R.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 52 Pages: 61-71
- DOI
  10.1007/s00535-016-1205-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling.2017
- Author(s)
  Teratani Toshiaki、Tomita Kengo、Suzuki Takahiro、Furuhashi Hirotaka、Irie Rie、Hida Shigeaki、Okada Yoshikiyo、Kurihara Chie、Ebinuma Hirotoshi、Nakamoto Nobuhiro、Saito Hidetsugu、Hibi Toshifumi、Miura Soichiro、Hokari Ryota、Kanai Takanori
- Journal Title
  
  J Hepatol.
  
  Volume: 67 Pages: 780-790
- DOI
  10.1016/j.jhep.2017.05.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08756, KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15K09021, KAKENHI-PROJECT-15K19348, KAKENHI-PROJECT-15K09031
[Journal Article] Uric acid ameliorated indomethacin-induced enteropathy in mice through its antioxidant activity.2017
- Author(s)
  Yasutake Y, Tomita K, Higashiyama M, Furuhashi H, Shirakabe K, Takajo T, Maruta K, Sato H, Narimatsu K, Yoshikawa K, Okada Y, Kurihara C, Watanabe C, Komoto S, Nagao S, Matsuo H, Miura S, Hokari R.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 印刷中
- DOI
  10.1111/jgh.13785
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] ANGPTL2 increases renal fibrosis by accelerating TGF-β signaling in chronic kidney disease.2016
- Author(s)
  Jun Morinaga, Tsuyoshi Kadomatsu, Keishi Miyata, Motoyoshi Endo, Kazutoyo Terada, Zhe Tian, Taichi Sugizaki, Hiroki Tanigawa, Jiabin Zhao, Shunshun Zhu, Michio Sato, Kimi Araki, Ken-ichi Iyama, Kengo Tomita, Masashi Mukoyama, Kimio Tomita, Kenichiro Kitamura, Yuichi Oike
- Journal Title
  
  Kidney Int
  
  Volume: 89 Pages: 327-341
- DOI
  10.1016/j.kint.2015.12.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06836, KAKENHI-PROJECT-15K09031, KAKENHI-PROJECT-26461226, KAKENHI-PUBLICLY-15H01520, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-25461192, KAKENHI-PROJECT-26860639, KAKENHI-PROJECT-26861112, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-25461114, KAKENHI-PROJECT-26670405
[Journal Article] Platelet interaction with lyphatics aggravates intestinal inflammation by suppressing lymphangiogenesis.2016
- Author(s)
  Sato H, Higashiyama M, Hozumi H, Sato S, Furuhashi H, Takajo T, Maruta K, Yasutake Y, Narimatsu K, Yoshikawa K, Kurihara C, Okada Y, Watanabe C, Komoto S, Tomita K, Nagao S, Miura S, Hokari R.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: 311
- DOI
  10.1152/ajpgi.00455.2015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey.2016
- Author(s)
  Watanabe C, Komoto S, Tomita K, Hokari R, Tanaka M, Hirata I, Hibi T, Kaunitz JD, Miura S
- Journal Title
  
  J Gastroenterol
  
  Volume: 51 Pages: 327-336
- DOI
  10.1007/s00535-015-1107-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09031, KAKENHI-PROJECT-26460980
[Journal Article] Toll-like receptor (TLR) 2 agonists ameliorate indomethacin-induced murine ileitis by suppressing the TLR4 signaling.2015
- Author(s)
  Narimatsu K, Higashiyama M, Kurihara C, Takajo T, Maruta K, Yasutake Y, Sato H, Okada Y, Watanabe C, Komoto S, Tomita K, Nagao S, Miura S, Hokari R
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 30 Pages: 1610-1617
- DOI
  10.1111/jgh.12980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Magnetic resonance enterocolonography in detecting erosion and redness in intestinal mucosa of patients with Crohn's disease.2015
- Author(s)
  Sato H, Tamura C, Narimatsu K, Shimizu M, Takajyo T, Yamashita M, Inoue Y, Ozaki H, Furuhashi H, Maruta K, Yasutake Y, Yoshikawa K, Watanabe C, Komoto S, Tomita K, Nagao S, Miura S, Shinmoto H, Hokari R
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 30 Pages: 667-673
- DOI
  10.1111/jgh.12851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] No Contribution of the ABCB11 p.444A Polymorphism in Japanese Patients with Drug-Induced Cholestasis2015
- Author(s)
  Kagawa T, Hirose S, Arase Y, Oka A, Anzai K, Tsuruya K, Shiraishi K, Orii R, Ieda S, Nakazawa T, Tomita K, Hokari R, Miura S, Ebinuma H, Saito H, Kitamura T, Horie Y, Okuse C, Wasada M, Inoko H, Tohkin M, Saito Y, Maekawa K, Takikawa H, Mine T
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 43 Pages: 691-697
- DOI
  10.1124/dmd.114.061325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031, KAKENHI-PROJECT-25461011
[Journal Article] Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine.2015
- Author(s)
  Ueda T, Hokari R, Higashiyama M, Yasutake Y, Maruta K, Kurihara C, Tomita K, Komoto S, Okada Y, Watanabe C, Usui S, Nagao S, Miura S
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 21 Pages: 177-186
- DOI
  10.3748/wjg.v21.i1.177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Randomized study comparing vitamin D3 and 1α-Hydroxyvitamin D3 in combination with pegylated interferon/ribavirin therapy for chronic hepatitis C.2015
- Author(s)
  Omori-Mizuno Y, Nakayama N, Inao M, Funyu J, Asabe S, Tomita K, Nishikawa K, Hosoda Y, Tanaka M, Hashimoto Y, Yakabi K, Koshima Y, Mochida S
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 30 Pages: 1384-1390
- DOI
  10.1111/jgh.12949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Pregnant woman with non-comatose autoimmune acute liver failure in the second trimester rescued using medical therapy: A case report.2015
- Author(s)
  Sato H, Tomita K, Yasue C, Umeda R, Ebinuma H, Ogata S, Du W, Soga S, Maruta K, Yasutake Y, Narimatsu K, Usui S, Watanabe C, Komoto S, Teratani T, Suzuki T, Yokoyama H, Saito H, Nagao S, Hibi T, Miura S, Kanai T, Hokari R.
- Journal Title
  
  Hepatology Research
  
  Volume: 45 Pages: 349-355
- DOI
  10.1111/hepr.12344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Lethal hemorrhage from duodenal ulcer due to small pancreatic cancer.2015
- Author(s)
  Higashiyama M, Suzuki H, Watanabe C, Tomita K, Komoto S, Nagao S, Nakanishi K, Miura S, Hokari R
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 8 Pages: 236-239
- DOI
  10.1007/s12328-015-0586-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Recombinant Thrombomodulin Modulates Murine Colitis Possibly via High-Mobility Group Box 1 Protein Inhibition.2015
- Author(s)
  Ueda T, Higashiyama M, Narimatsu K, Yasutake Y, Kurihara C, Okada Y, Watanabe C, Yoshikawa K, Maruta K, Komoto S, Tomita K, Nagao S, Hokari R, Miura S
- Journal Title
  
  Digestion
  
  Volume: 92 Pages: 108-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09031
[Journal Article] Free cholesterol accumulation in hepatic stellate cells : mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice2014
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Hepatology
  
  Volume: 59(1) Pages: 154-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] A pregnant woman with noncomatose autoimmune acute liver failure in the second trimester rescued using medical therapy : A case report2014
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Hepatol Res.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Prevalence of serum celliac antibody in patients with IBD in Japan2014
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Gastroenterol
  
  Volume: 49(5) Pages: 825-834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Free cholesterol accumulation in hepatic stellate cells : Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice2014
- Author(s)
  Tomita, K. Teratani, T. Suzuki, T. Shimizu, M. Sato, H. Narimatsu, K. Okada, Y. Kurihara, C. Irie, R. Yokoyama, H. Shimamura, K. Usui, S. Ebinuma, H. Saito, H. Watanabe, C. Komoto, S. Kawaguchi, A. Nagao, S. Sugiyama, K. Hokari, R. Kanai, T. Miura, S. Hibi, T.
- Journal Title
  
  Hepatology
  
  Volume: 59 Pages: 154-169
- DOI
  10.1002/hep.26604
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-24390190, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-24790719
[Journal Article] Fibroblast growth factor-5 participates in the progression of hepatic fibrosis2014
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Exp Anim
  
  Volume: 63(1) Pages: 85-92
- NAID
  130003391608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Acyl-CoA : cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells2014
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Hepatol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.2014
- Author(s)
  Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Usui S, Furuhashi H, Kimura A, Nishiyama K, Maejima T, Okada Y, Kurihara C, Shimamura K, Ebinuma H, Saito H, Yokoyama H, Watanabe C, Komoto S, Nagao S, Sugiyama K, Aosasa S, Hatsuse K, Yamamoto J, Hibi T, Miura S, Hokari R, Kanai T.
- Journal Title
  
  J Hepatol.
  
  Volume: 印刷中 Pages: 98-106
- DOI
  10.1016/j.jhep.2014.03.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24590993, KAKENHI-PROJECT-24790719
[Journal Article] Trans fatty acids in diets act as a precipitating factor for gut inflammation?2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 4 Pages: 29-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease : Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY)2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Int J Endocrinol
  
  Volume: 2013 Pages: 587140-587140
- DOI
  10.1155/2013/587140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the upregulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Clin Exp Immunol
  
  Volume: 174(3) Pages: 459-471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] 1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii reduces inflammation in interleukin-10-deficient mice with colitis by suppressing macrophage-derived proinflammatory cytokines2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Leukoc Biol
  
  Volume: 94 Pages: 473-480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice2013
- Author(s)
  Chu PS, Nakamoto N, Ebinuma H, Usui S, Saeki K, Matsumoto A, Mikami Y, Sugiyama K, Tomita K, Kanai T, Saito H, Hibi T.
- Journal Title
  
  Hepatology
  
  Volume: 58 Pages: 337-350
- DOI
  10.1002/hep.26351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J05920, KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24249046
[Journal Article] Endoscopic finding of spontaneous hemorrhage correlates with tumor necrosis factor alpha expression in colonic mucosa of patients with ulcerative colitis2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Dis Int J Colorectal
  
  Volume: 28 Pages: 1049-1055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Phlebosclerotic colitis that was difficult to distinguish from collagenous colitis2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Dig Endosc
- DOI
  10.1111/den.12151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Lab Invest
  
  Volume: 93 Pages: 508-519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Hepatology
  
  Volume: 58 Pages: 337-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion2013
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells.2012
- Author(s)
  Teratani T, Tomita K, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Tominaga S, Hiroi S, Irie R, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Kanai T, Miura S, Hibi T
- Journal Title
  
  Gastroenterology
  
  Volume: 142 Pages: 152-164
- DOI
  10.1053/j.gastro.2011.09.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001
[Journal Article] p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice2012
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Hepatol
  
  Volume: 57 Pages: 837-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice2012
- Author(s)
  Tomita K, Teratani T, Shimamura K, Nishiyama N, Mataki R, Irie T, Minamino Y, Okada C, Kurihara H, Sugiyama K, et al
- Journal Title
  
  Journal of Hepatology
  
  Volume: 57 Pages: 837-843
- DOI
  10.1016/j.jhep.2012.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590551, KAKENHI-PROJECT-23591001, KAKENHI-PROJECT-24790719
[Journal Article] A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells2012
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Gastroenterology
  
  Volume: 142 Pages: 152-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Indomethacin-induced small intestinal injury is ameliorated by cilostazol, a specific PDE-3 inhibitor2012
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Scand J Gastroenterol
  
  Volume: 47 Pages: 993-1002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis2012
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Leukoc Biol
  
  Volume: 91 Pages: 901-909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.2011
- Author(s)
  Onoyama I, Suzuki A, Matsumoto A, Tomita K, et al.
- Journal Title
  
  The Journal of Clinical Investigation
  
  Volume: 121 Pages: 342-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Fbxw7 controls lipid metabolism and cell fate decision in the liver.2011
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Clin Invest 121
  
  Pages: 342-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver2011
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Pages: 342-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Serum immunoglobulin A concentration is an independent predictor of liver fibrosis in nonalcoholic steatohepatitis before the cirrhotic stage2011
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 56 Pages: 3648-3654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Plasma free myristic acid proportion is a predictor of nonalcoholic steatohepatitis.2011
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Dig Dis Sci (in press.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Plasma free myristic acid proportion is a predictor of nonalcoholic steatohepatitis2011
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 56 Pages: 3648-3654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591001
[Journal Article] Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis.2009
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Clin Invest 119
  
  Pages: 1477-1488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Utility of quantitative 99mTc-phytate scintigraphy to diagnose early-stage non-alcoholic steatohepatitis.2009
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Scand J Gastroenterol 44
  
  Pages: 229-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis.2008
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Hepatology 48
  
  Pages: 458-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Hepatic AdipoR2 signaling plays a protective role aganist progression of nonalcoholic steatohepatitis in mice.2008
- Author(s)
  Tomita K, et al.
- Journal Title
  
  Hepatology 48
  
  Pages: 458-473
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Evaluating the severity of nonalcoholic steatohepatitis with superparamagnetic iron oxide-enhanced magnetic resonance imaging.2008
- Author(s)
  Tomita K, et al.
- Journal Title
  
  J Magn Reson Imaging 28
  
  Pages: 1444-1450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590796
[Journal Article] Tumour necrosis factor alpha signaling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.2006
- Author(s)
  Kengo Tomita
- Journal Title
  
  Gut 55・3
  
  Pages: 415-424
- Data Source
  KAKENHI-PROJECT-15790359
[Journal Article] AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats.2005
- Author(s)
  Kengo Tomita
- Journal Title
  
  Alcohol Clin Exp Res 29・12 Suppl
- Data Source
  KAKENHI-PROJECT-15790359
[Journal Article] Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met.2004
- Author(s)
  Kengo Tomita et al.
- Journal Title
  
  Gastroenterology 126・3
  
  Pages: 873-885
- NAID
  10012355311
- Data Source
  KAKENHI-PROJECT-15790359
[Journal Article] Leptin deficiency enhances sensitivity of rats to alcoholic steatohepatitis through suppression of metallothionein.2004
- Author(s)
  Kengo Tomita et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 287・5
- Data Source
  KAKENHI-PROJECT-15790359
[Presentation] 新規Wntリガンドである、Aortic carboxypeptidase-like proteinは、非アルコール性脂肪肝炎病態を増悪させる.2018
- Author(s)
  冨田謙吾、寺谷俊昭、金井隆典
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K07924
[Presentation] ASH/NASH新規治療標的としての、肝星細胞遊離コレステロール制御機構の解析2015
- Author(s)
  冨田謙吾、穂苅量太、金井隆典
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本県熊本市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K09031
[Presentation] The characteristic Mechanisms of Free Cholesterol Accumulation in Hepatic Stellate Cells Aggravate liver fibrosis in Nonalcoholic Steatohepatitis in Mice2013
- Author(s)
  Tomita K, Teratani T, Suzuki T, Yokoyama H, Shimamura K, Nishiyama K, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Hibi T, Miura S.
- Organizer
  The 48th Annual Meeting of the European Associatiion for the Study of Liver Diseases
- Place of Presentation
  オランダ　アムステルダム
- Data Source
  KAKENHI-PROJECT-23591001
[Presentation] The characteristic Mechanisms of Free Cholesterol Accumulation in Hepatic Stellate Cells Aggravate liver fibrosis in Nonalcoholic Steatohepatitis in Mice2013
- Author(s)
  Tomita K
- Organizer
  The 48th Annual Meeting of the European Association for the Study of Liver Diseases
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-23591001
[Presentation] 肝星細胞の遊離コレステロール蓄積を介した、肝臓線維化進展機序の解析2012
- Author(s)
  冨田謙吾、寺谷俊昭、日比紀文
- Organizer
  第39回日本肝臓学会東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591001
[Presentation] 肝臓P53/p66Shcシグナル増強は、ヒトNASH病態を進展させる増悪因子である2012
- Author(s)
  冨田謙吾、日比紀文、三浦総一郎
- Organizer
  第39回日本肝臓学会東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591001
[Presentation] p53/p66Shc signaling pathway plays a role in nonalcoholic steatohepatitis progression in human and mice.2012
- Author(s)
  Tomita K, Teratani T, Suzuki T, Yokoyama H, Shimamura K, Nishiyama K, Okada Y, Kurihara C, Ebinuma H, Saito H, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Hibi T, Miura S
- Organizer
  The 47th Annual Meeting of the European Associatiion for the Study of Liver Diseases
- Place of Presentation
  スペイン　バルセロナ
- Data Source
  KAKENHI-PROJECT-23591001
[Presentation] p53/p66Shc signaling pathway plays a role in nonalcoholic steatohepatitis progression in human and mice2012
- Author(s)
  Tomita K
- Organizer
  The 47th Annual Meeting of the European Association for the Study of Liver Diseases
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23591001
[Presentation] コレステロール多量摂取は、肝星細胞の遊離コレステロール蓄積を介して、肝臓線維化進展を引き起こす2012
- Author(s)
  冨田謙吾、寺谷俊昭、鈴木貴博、横山裕一、岡田義清、栗原千枝、海老沼浩利、齋藤英胤、渡辺知佳子、高本俊介、穂苅量太、川口淳、永尾重昭、杉山和夫、金井隆典、日比紀文、三浦総一郎
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23591001
[Presentation] 非アルコール性脂肪肝炎(nonalcoholic steatohepatitis : NASH)発症・進展における、adiponectin/AdipoR2シグナルの果たす役割に関する検討2009
- Author(s)
  冨田謙吾
- Organizer
  第5回宮崎サイエンスキャンプ
- Place of Presentation
  宮崎
- Year and Date
  2009-02-20
- Data Source
  KAKENHI-PROJECT-20590796
[Presentation] 非アルコール性脂肪肝炎病態機序における、抗酸化酵素catalaseを介した肝臓アディポネクチン感受性・抵抗性の役割に関する検討2008
- Author(s)
  冨田謙吾
- Organizer
  日本応用酵素協会第34回研究発表会
- Place of Presentation
  大阪
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20590796

1. SHIMIZU Takahiko (40301791)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. OIKE Yuichi (90312321)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. HORIE Yoshinori (70229227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SHIRASAWA Takuji (80226323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SEKI Shuji (80531392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KATO Shinzo (30177448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAITO Hidetsugu (80186949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. INOKUCHI Sayaka (00383711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKANO Hideyuki (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 石井裕正 (20051500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 東俊文 (00222612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUGIYAMA Kazuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. ENDO Motoyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. KADOMATSU Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. TIAN Zhe

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. SAITO Yoshimasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. ISHIZUKA Toshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 斎藤英胤

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
19. 森潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 向山政志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 森永潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 宮田敬士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 荒木喜美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 柴田理恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 金井隆典

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
26. 寺谷俊昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
27. 渡邉知佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
28. 南野徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 北村庸雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 日比紀文

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 斎藤義正

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tomita Kengo 冨田 謙吾

TOMITA Kengo 冨田 謙吾

Research Projects

Research Products

Co-Researchers

過栄養・肥満による臓器線維化の不顕性進展機構の解明と、疾患治療への応用Principal Investigator

Principal Investigator

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Elucidation of the pathological mechanism of obesity-related liver cancer and development of the new treatment methods, focusing on secretory factors from hepatic stellate cellsPrincipal Investigator

Principal Investigator

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Review Section

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Establishment of novel therapies for steatohepatitis and liver cancer, by targeting the free cholesterol-mediated signaling pathway.Principal Investigator

Principal Investigator

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Unraveling the role of Angptl2 in the pathogenesis of steatohepatitis and liver cancerPrincipal Investigator

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Molecular mechanism for aging control

Principal Investigator

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Analysis of the paradoxical correlation between hepatic insulin resistance and oxidative stress in the pathogenesis of steatohepatitisPrincipal Investigator

Principal Investigator

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Involvement of Angpt14 in the pathological mechanisms of steatosis and steatohepatitisPrincipal Investigator

Principal Investigator

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肝細胞の脂肪化におけるレチノイン酸X受容体の役割とその治療応用に関する検討Principal Investigator

Principal Investigator

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Experimental research for treatment of liver failure with hepatic tissue stem cell (SP cell)

Principal Investigator

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肝細胞の長期培養系の確立:特にレチノイン酸、ステロイドホルモン代謝の役割についてPrincipal Investigator

Principal Investigator

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[Journal Article] Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine-1-phosphate lyase inhibitor.2019

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[Journal Article] Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.2019

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[Journal Article] Nicotine treatment ameliorates DSS-induced colitis by suppressing MAdCAM-1 expression and leukocyte recruitment.2018

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Tomita Kengo 冨田謙吾

TOMITA Kengo 冨田謙吾