NAKANISHI Akira 中西啓

Researcher Number	50321790
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2022: 東京医科歯科大学, 難治疾患研究所, 准教授 2012 – 2018: 東京医科歯科大学, 難治疾患研究所, 准教授 2017: 東京医科歯科大学, 難治疾患研究所, 特任准教授 2011 – 2012: 東京医科歯科大学, 難治疾患研究所, 特任准教授
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Tumor biology / Tumor biology / Human genetics / Tumor diagnostics
Keywords	Principal Investigator 合成致死性 / 核輸送 / Importinβ / KPNA7 / BRCA2 Except Principal Investigator BRCA2 / 乳がん / がん抑制遺伝子 / 癌 / 抗がん剤 … More / MT1-MMP / プロテオーム / 蛋白質 / 細胞・組織 / 遺伝学 / BRCA / リサイクリングエンドソーム / 遺伝子 / がん / DNA 損傷修復 / BRCA遺伝子 / PARP阻害剤 / 合成致死療法 / BRCA1/2 / エストロゲン受容体α / エストロゲン受容体 / エストロゲン / エンドサイトーシス / ESCRT複合体 / エンドサイトーシ / BRCA1/BRCA2 / BRCA1/2遺伝子 / 化合物ライブラリー / 合成致死 / 中心体 / 発がん / ゲノム安定性 Less

DNA修復分子の核内輸送機構を標的とする新たな合成致死がん治療の開発基盤研究Principal Investigator
- Principal Investigator
  
  中西啓
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Medical and Dental University
Study on new treatment of breast cancer targeting BRCA gene function
- Principal Investigator
  
  MIKI Yoshio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University
遺伝性乳がん原因遺伝子産物ＢＲＣＡ２のリサイクリングエンドソームにおける機能解析
- Principal Investigator
  
  高岡美帆
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Medical and Dental University
Role of BRCA2 in the process of estrogen-dependent cell proliferation
- Principal Investigator
  
  MIKI Yoshio
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnostics
- Research Institution
  Tokyo Medical and Dental University
Elucidation of the new mechanism for breast carcinogenesis associated with early endosome.
- Principal Investigator
  
  MIKI Yoshio
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University
Functional analysis of BRCA genes and searching for molecular partner for synthetic lethality.
- Principal Investigator
  
  MIKI Yoshio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University
Analysis for a new mechanism of neoplastic cell transformation through the centrosome control with MT1-MMP
- Principal Investigator
  
  MIKI Yoshio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University

All 2021 2018 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer.2018
- Author(s)
  Sunada S, Nakanishi A, Miki Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 109 Issue: 4 Pages: 893-899
- DOI
  10.1111/cas.13530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19473, KAKENHI-PUBLICLY-18H04898, KAKENHI-PROJECT-16H04693, KAKENHI-PROJECT-17H06651
[Journal Article] FKBP51 regulates cell motility and invasion via RhoA signaling.2017
- Author(s)
  Takaoka M, Ito S, Miki Y, Nakanishi A.
- Journal Title
  
  Cancer Sci.
  
  Volume: 103 Issue: 3 Pages: 380-389
- DOI
  10.1111/cas.13153
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14394, KAKENHI-PROJECT-16K08639, KAKENHI-PUBLICLY-16H01570, KAKENHI-PROJECT-16H04693
[Journal Article] BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.2016
- Author(s)
  Malik S, Saito H, Takaoka M, Miki Y, Nakanishi A.
- Journal Title
  
  Cell Cycle.
  
  Volume: 15 Pages: 2145-2156
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14394
[Journal Article] BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.2016
- Author(s)
  Malik S, Saito H, Takaoka M, Miki Y, Nakanishi A.
- Journal Title
  
  Cell Cycle
  
  Volume: 15 Pages: 2145-2156
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04693
[Journal Article] Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.2014
- Author(s)
  Tan TZ, Miow QH, Miki Y, Noda T, Mori S, Huang RY, Thiery JP.
- Journal Title
  
  EMBO Mol Med.
  
  Volume: 6 Issue: 12 Pages: 1279-1293
- DOI
  10.4161/cc.28896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300328, KAKENHI-PUBLICLY-25134709, KAKENHI-PROJECT-25640061
[Journal Article] Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion.2014
- Author(s)
  Ishiba T, Nagahara M, Nakagawa T, Sato T, Ishikawa T, Uetake H, Sugihara K, Miki Y, Nakanishi A.
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 7069-7069
- DOI
  10.1038/srep07069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300328, KAKENHI-PUBLICLY-25134709
[Journal Article] BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC.2014
- Author(s)
  Takaoka, Saito, Takenaka, Miki, and Nakanishi
- Journal Title
  
  Cancer Research
  
  Volume: 74 Issue: 5 Pages: 1518-1528
- DOI
  10.1158/0008-5472.can-13-0504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590355, KAKENHI-PROJECT-24300328, KAKENHI-PUBLICLY-25134709, KAKENHI-PROJECT-25640061
[Journal Article] Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP).2014
- Author(s)
  Wali N, Hosokawa K, Malik S, Saito H, Miyaguchi K, Imajoh-Ohmi S, Miki Y, Nakanishi A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 443 Issue: 4 Pages: 1148-1154
- DOI
  10.1016/j.bbrc.2013.12.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300328, KAKENHI-PUBLICLY-25134709, KAKENHI-PROJECT-25640061
[Journal Article] BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.2011
- Author(s)
  Wang HF, Takenaka K, Nakanishi A, Miki Y.
- Journal Title
  
  Cancer Res.
  
  Volume: 71 Pages: 68-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] Elucidation of the BRCA2 nuclear transport system2021
- Author(s)
  Shiori Hirayama, Ami Sato, Yu Deng, Akira Nakanishi, Yoshio Miki
- Organizer
  第８０回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02759
[Presentation] 乳癌の治療戦略 DNA損傷応答を標的とした新たな乳がん治療戦略，2018
- Author(s)
  三木義男, 中西啓
- Organizer
  第26回日本乳癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] エストロゲンによる乳管及び基底膜崩壊機構の解析2018
- Author(s)
  Deng Yu, 中西啓, 三木義男
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] FKBP51 のRhoAシグナル経路を通した細胞の遊走能、浸潤能の制御2017
- Author(s)
  髙岡美帆、伊藤駿、中西啓、三木義男
- Organizer
  第７６回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2017-09-28
- Data Source
  KAKENHI-PROJECT-16K08639
[Presentation] BRCA2ノックダウン細胞に対するパクリタキセルによる合成致死誘導機構の解明2017
- Author(s)
  山田翔太、高岡美帆、中西啓、三木義男
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] BRCA2とエストロゲン受容体相互作用による生理的役割2017
- Author(s)
  東條陽、佐藤亜美、高岡美帆、中西啓、三木義男
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] 三次元基底膜培養のMCF-10A乳腺上皮腺房に対するエストロゲンの作用効果2017
- Author(s)
  Yu Deng、高岡美帆、中西啓、三木義男
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] HBOC発症の分子機構と新規治療戦略2016
- Author(s)
  三木義男, 中西啓
- Organizer
  第24回日本乳癌学会総会
- Place of Presentation
  東京ビッグサイト（東京都江東区）
- Year and Date
  2016-06-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K14394
[Presentation] M期染色体におけるBRCA2タンパク質のインタラクトーム解析2016
- Author(s)
  大塚菜央，高岡美帆，中西啓，三木義男；
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K14394
[Presentation] エストラジオール誘導によるBRCA2遺伝子発現機構の解析2016
- Author(s)
  佐藤亜美，高岡美帆，中西啓，三木義男
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] M期染色体におけるBRCA2タンパク質のインタラクトーム解析2016
- Author(s)
  大塚菜央，高岡美帆，中西啓，三木義男
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] エストラジオール誘導によるBRCA2遺伝子発現機構の解析2016
- Author(s)
  佐藤亜美，高岡美帆，中西啓，三木義男
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K14394
[Presentation] HBOC発症の分子機構と新規治療戦略2016
- Author(s)
  三木義男, 中西啓
- Organizer
  第24回日本乳癌学会総会
- Place of Presentation
  東京ビッグサイト（東京都江東区）
- Year and Date
  2016-06-16
- Invited
- Data Source
  KAKENHI-PROJECT-16H04693
[Presentation] 遺伝性乳癌患者でみられるBRCA2 遺伝子内の変異が細胞質分裂に与える影響2013
- Author(s)
  高岡美帆、斉藤広子、中西啓、三木義男
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24300328
[Presentation] Functional analysis of a cleavage product of BRCA2 in cancer cell lines2013
- Author(s)
  Nadila Wali, Kana Hosokawa, Hiroko Saito, Shinobu Ohmi, Akira Nakanishi, Yoshio Miki,
- Organizer
  ASCB 2013 Annual meeting
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-24300328
[Presentation] Functional analysis of a cleavage product of BRCA2 in cancer cell lines2013
- Author(s)
  Nadila Wali, Kana Hosokawa, Hiroko Saito, Shinobu Ohmi, Akira Nakanishi, Yoshio Miki,
- Organizer
  ASCB 2013 Annual meeting,
- Place of Presentation
  New Orleans, LA, USA,
- Data Source
  KAKENHI-PROJECT-25640061
[Presentation] 遺伝性乳癌患者でみられるBRCA2 遺伝子内の変異が細胞質分裂に与える影響．2013
- Author(s)
  高岡美帆、斉藤広子、中西啓、三木義男
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25640061
[Presentation] The correlation of decorin and periostin indicated by the proteomics of phyllodes葉状腫瘍のプロテオーム解析から導いたdecorinとperiostinの関連性2012
- Author(s)
  石場俊之,中西啓,高木洋子,笠原舞,杉本斉,永原誠,中川剛士,佐藤隆宣,杉原健一,三木義男
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] Hereditary breast/ovarian cancer -New development of the molecular diagnosis and treatment-遺伝性乳がん・卵巣がん症候群-分子診断・治療の新たな展開2012
- Author(s)
  三木義男,中西啓
- Organizer
  第71回日本癌学会学術総会シンポジウム
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] Proteasome activity affects cancerous centrosome hypertrophy プロテアソームの活性は癌細胞における中心体の肥大化に影響する2012
- Author(s)
  木村仁美,中西啓,三木義男
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] Phosphorylation of BRCA2 by Akt is involved in BRCA2-14-3-3 gamma interaction related to centrosome dynamics 中心体制御に関わるBRCA2‐14-3-3γ複合体形成にはAktによるBRCA2のリン酸化が関与する2012
- Author(s)
  宮口健,郭甜甜,三木義男,中西啓
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] Phosphorylation of BRCA2 by Akt is involved in BRCA2-14-3-3 gamma interaction related to centrosome dynamics2012
- Author(s)
  Miyaguchi K,Miki Y, Nakanishi A
- Organizer
  15th International Congress on Hormonal Steroids and Hormones& Cancer
- Place of Presentation
  Kanazawa
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] BRCA2の新規機能と合成致死理論に基づく新規乳癌治療法開発の可能性2012
- Author(s)
  三木義男,中西啓
- Organizer
  第20回日本乳癌学会学術総会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] BRCA2 contributes success of cytokinesis through regulation ofnon-muscle myosin IIC ATPase activity乳癌原因遺伝子産物BRCA2はII型ミオシンIICのATPase活性の制御を通して細胞質分裂に働く2012
- Author(s)
  高岡美帆,斉藤広子,中西啓,三木義男
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] 遺伝性乳癌・卵巣癌症候群－基礎から臨床－2011
- Author(s)
  三木義男、斉藤広子、中西啓
- Organizer
  日本人類遺伝学会第56回大会・第11回東アジア人類遺伝学会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] New insights into the cellular function of BRCA2.2011
- Author(s)
  Miki Y, Takenaka K, Nakanishi A.
- Organizer
  70th Annual Meeting of the Japanese Cancer Association(招待講演)
- Place of Presentation
  Nagoya, Japan,
- Data Source
  KAKENHI-PROJECT-23650592
[Presentation] BRCA2欠失乳細胞に合成致死を誘導する有効な低分子化合物の同定
- Author(s)
  清水優香、湯浅磨里、中西啓、三木義男
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24300328
[Presentation] M期中心体におけるMT1-MMPのBRCA2タンパク分解
- Author(s)
  高岡美帆、ナディラワリ、斎藤広子、中西啓、三木義男
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24300328
[Presentation] BRCA2の新規機能解明に基づく診断・治療法の開発
- Author(s)
  中西啓、三木義男
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24300328
[Presentation] M期中心体におけるMT1-MMPのBRCA2タンパク分解
- Author(s)
  １０．高岡美帆、ナディラワリ、斎藤広子、中西啓、三木義男
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25640061
[Presentation] 切断型BRCA2の形成機序および機能解析
- Author(s)
  中西啓,Nadila Wali,斉藤広子,大(1)研究代表者海,三木義男
- Organizer
  日本人類遺伝学会第57回大会
- Place of Presentation
  新宿区
- Data Source
  KAKENHI-PROJECT-23650592

1. MIKI Yoshio (10281594)

# of Collaborated Projects: 7 results

# of Collaborated Products: 39 results
2. 高岡美帆 (90770701)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TAKENAKA Katsuya (20378706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 砂田成章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKANISHI Akira 中西 啓

Research Projects

Research Products

Co-Researchers

DNA修復分子の核内輸送機構を標的とする新たな合成致死がん治療の開発基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on new treatment of breast cancer targeting BRCA gene function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝性乳がん原因遺伝子産物ＢＲＣＡ２のリサイクリングエンドソームにおける機能解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of BRCA2 in the process of estrogen-dependent cell proliferation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the new mechanism for breast carcinogenesis associated with early endosome.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of BRCA genes and searching for molecular partner for synthetic lethality.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis for a new mechanism of neoplastic cell transformation through the centrosome control with MT1-MMP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FKBP51 regulates cell motility and invasion via RhoA signaling.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.2016

Author(s)

Journal Title

Data Source

[Journal Article] BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.2016

Author(s)

Journal Title

Data Source

[Journal Article] Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP).2014

NAKANISHI Akira 中西啓