KIYOHARA Tatsuya 清原達也

Researcher Number	50322178
Other IDs
Affiliation (based on the past Project Information) *help	2002 – 2006: Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 2000 – 2001: Osaka Unversity Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator CD40 / IL-10 / クローン病 / マウス / アディポネクチン / DSS colitis / Crohn's disease / IL-10 deficient mice / Adiponectin deficient mice / Adiponectin … More / アディポネタチン欠損マウス / アディポネクチン過剰発現 / DSS腸炎 / IL-10欠損マウス / アディポネクチン欠損マウス / lipopolysaccharide / mice / macrophage / Conh's disease / IL-12 / TNFα / エンドトキシン / マクロファージ / セルレイン膵炎 / 急性膵炎 … More Except Principal Investigator CD9 / c-kit / ガストリン / Helicobacter Pylori / p38MAPK / HB-EGF / IL-1 / Helicobacter pylori / gastrin / TRAF6 / NIK / protein kinase C / IKK / 胃上皮細胞 / NF-kappaB / アポトーシス / 胃癌 / Apoptosis / Gastrointestinal Cancer / 消化器癌 / Gastrin / Proliferation / Differentiation / MMK6 / Gastric Mucosal Cell / 分化・増殖 / 増殖 / 分化 / MKK6 / gastritis / gastric cancer / PKC / メチル化 / p38-MAPK / NF-κB / 胃炎 / gastric epithelial cells / H-pylori / H.pylori / apoptosis / mutation / leiomyosarcoma / leimyoma / gastrointestinal stromal tumor / 遺伝子変異 / 平滑筋肉腫 / 平滑筋腫 / 消化管腫瘍 / pacemaker / interstitial cells of Cajal / gastrointestinal motility / カハール / 消化管運動異常症 / ペースメーカー / カハール介在細胞 / 消化管運動 / EGF / HGF / 悪性黒色腫 / 大腸癌 / 転移 Less

急性膵炎における低アディポネクチン血症の関与の解明と治療への応用の基礎研究Principal Investigator
- Principal Investigator
  
  TSUTSUI Shusaku, 清原達也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of treatment for gastrointestinal cancer using CD-9 mediated apoptosis
- Principal Investigator
  
  TSUTSUI Shusaku
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of new treatment for the patients with inflammatory bowel disease by adiponectinPrincipal Investigator
- Principal Investigator
  
  KIYOHARA Tatsuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Analysis of proliferation and differentiation in the gastric epithelial cells derived from p38MAPK transgene mouse.
- Principal Investigator
  
  TSUTSUI Shusaku
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
新規癌転移関連分子Mlzeの機能解析-消化器癌の転移における役割-
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Interaction of proinflammatory cytokines and growth factors in gastric carcinogenesis
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of a new therapy of Chohn's disease by the regulation of Macrophage/Monocyte functionPrincipal Investigator
- Principal Investigator
  
  KIYOHARA Tatsuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Role of NF-kappaB in the growth, differentiation and apoptosis of gastric epithelial cells
- Principal Investigator
  
  MIYAZAKI Yoshiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Effect of gain-of-function mutation of c-kit on apoptosis in gastrointestinal mesenchymal cells
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
Development of novel therapeutics targeting the function of intestinal cells of Cajal in gastrointestinal motility disorder
- Principal Investigator
  
  SHINOMURA Yasuhisa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University

All 2005 2004 2003 2002

All Journal Article

[Journal Article] Gefitinib (‘Iressa', ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.2005
- Author(s)
  Kishida O, Miyazaki Y, Murayama Y, Ogasa M, Miyazaki T, Yamamoto T, Watabe K, Tsutsui S, Kiyohara T, Shimomura I, Shinomura Y.
- Journal Title
  
  Cancer Chemoth.Pharm. 55(4)
  
  Pages: 393-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.2004
- Author(s)
  Murayama Y, Miyagawa J, Oritani K, Yoshida H, Yamamoto K, Kishida O, Miyazaki T, Tsutsui S, Kiyohara T, Miyazaki Y, Higashiyama S, Matsuzawa Y, Shinomura Y
- Journal Title
  
  J Cell Sci. 117(Pt 15)
  
  Pages: 3379-3388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Helicobacter pylori-induced enlarged-fold gastritis is associated with increased mutagenicity of gastric juice, increased oxidative DNA damage, and an increased risk of gastric carcinoma.2003
- Author(s)
  Nishibayashi H, Kanayama S, Kiyohara T, Yamamoto K, Miyazaki Y, Yasunaga Y, Shinomura Y, Takeshita T, Takeuchi T, Morimoto K, Matsuzawa Y
- Journal Title
  
  J Gastroenterol Hepatol. 18(12)
  
  Pages: 1384-1391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003
- Author(s)
  Kinoshita K, Isozaki K, Tsutsui S, Kitamura S, Hiraoka S, Watabe K, Nakahara M, Nagasawa Y, Kiyohara T, Miyazaki Y, Hirota S, Nishida T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  Eur J Gastroenterol Hepatol. 15(11)
  
  Pages: 1189-1193
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] A decreased number of c-kit-expressing cells in a patient with afferent loop syndrome.2003
- Author(s)
  Kiyohara T.
- Journal Title
  
  J Gastroenterol. 38(4)
  
  Pages: 390-394
- NAID
  10012737590
- Data Source
  KAKENHI-PROJECT-15590645
[Journal Article] A decreased number of c-kit-expressing cells in a patient with afferent loop syndrome.2003
- Author(s)
  Kiyohara T et al.
- Journal Title
  
  J Gastroenterol 38(4)
  
  Pages: 390-393
- NAID
  10012737590
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390233
[Journal Article] Gastrin activates nuclear factor kappaB (NFkappaB) through a protein kinase C dependent pathway involving NFkappaB inducing kinase, inhibitor kappaB (IkappaB) kinase, and tumor necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor.2003
- Author(s)
  Ogasa M, Miyazaki Y, Hiraoka S, Kitamura S, Nagasawa Y, Kishida O, Miyazaki T, Kiyohara T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  Gut. 52(6)
  
  Pages: 813-819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Enhanced macrophage responsiveness to lipopolysaccharide and CD40 stimulation in a murine model of inflammatory bowel disease : IL-10-deficient mice.2002
- Author(s)
  Takakura R, Kiyohara T, Murayama Y, Miyazaki Y, Miyoshi Y, Shinomura Y, Matsuzawa Y
- Journal Title
  
  Inflamm Res. 51(8)
  
  Pages: 409-415
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Epidermal growth factor inhibits the growth of TE8 esophageal cancer cells through the activation of STAT1.2002
- Author(s)
  Ichiba M, Miyazaki Y, Kitamura S, Kiyohara T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  J Gastroenterol. 37(7)
  
  Pages: 498-503
- NAID
  50000581934
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer.2002
- Author(s)
  Murayama Y, Miyagawa J, Shinomura Y, Kanayama S, Isozaki K, Yamamori K, Mizuno H, Ishiguro S, Kiyohara T, Miyazaki Y, Taniguchi N, Higashiyama S, Matsuzawa Y
- Journal Title
  
  Int.J.Cancer 98(4)
  
  Pages: 505-513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181
[Journal Article] Deficiency of KIT positive cells in the colon of patients with diabetes mellitus.2002
- Author(s)
  Nakahara M, Isozaki K, Hirota S, Vanderwinden JM, Takakura R, Kinoshita K, Miyagawa J, Chen H, Miyazaki Y, Kiyohara T, Shinomura Y, Matsuzawa Y
- Journal Title
  
  J.Gastroenterol.Hepatol. 17(6)
  
  Pages: 666-670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370181

1. SHINOMURA Yasuhisa (90162619)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
2. MIYAZAKI Yoshiji (30303960)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
3. TSUTSUI Shusaku (10359846)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. MURAYAMA Yoko

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. FUNAHASI Toru (60243234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. WATABE Kenji (50379244)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KITAMURA Shinji

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 金山周次 (40185913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUJIMOTO Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中原征則

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 上山晴美

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 近藤真也

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KIYOHARA Tatsuya 清原 達也

Research Projects

Research Products

Co-Researchers

急性膵炎における低アディポネクチン血症の関与の解明と治療への応用の基礎研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of treatment for gastrointestinal cancer using CD-9 mediated apoptosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new treatment for the patients with inflammatory bowel disease by adiponectinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of proliferation and differentiation in the gastric epithelial cells derived from p38MAPK transgene mouse.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規癌転移関連分子Mlzeの機能解析-消化器癌の転移における役割-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction of proinflammatory cytokines and growth factors in gastric carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new therapy of Chohn's disease by the regulation of Macrophage/Monocyte functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of NF-kappaB in the growth, differentiation and apoptosis of gastric epithelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of gain-of-function mutation of c-kit on apoptosis in gastrointestinal mesenchymal cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutics targeting the function of intestinal cells of Cajal in gastrointestinal motility disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Gefitinib (‘Iressa', ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Helicobacter pylori-induced enlarged-fold gastritis is associated with increased mutagenicity of gastric juice, increased oxidative DNA damage, and an increased risk of gastric carcinoma.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumors.2003

KIYOHARA Tatsuya 清原達也