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Nishihara Hiroshi  西原 広史

ORCIDConnect your ORCID iD *help
… Alternative Names

NISHIHARA Hiroshi  西原 広史

西原 広史  ニシハラ ヒロシ

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Researcher Number 50322805
Other IDs
External Links
Affiliation (Current) 2025: 慶應義塾大学, 医学部(信濃町), 教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 慶應義塾大学, 医学部(信濃町), 教授
2017 – 2018: 慶應義塾大学, 医学部(信濃町), 特任教授
2017: 独立行政法人国立病院機構北海道がんセンター(臨床研究部), 臨床研究部, がんゲノム医療センター長
2017: 北海道大学, 医学研究科, 教授
2016: 北海道大学, 医学研究科, 特任教授 … More
2016: 北海道大学, 医学研究科, 特任准教授
2015: 北海道大学, 医学(系)研究科(研究院), 特任教授
2015: 北海道大学, 大学院医学研究科, 特任准教授
2011 – 2015: 北海道大学, 医学(系)研究科(研究院), 特任准教授
2014: 北海道大学, 医学研究科, 特任准教授
2012 – 2013: 北海道大学, 医学(系)研究科(研究院), 准教授
2009: 北海道大学, 大学院・医学研究科, 准教授
2008 – 2009: Hokkaido University, 大学院・医学研究科, 特任准教授
2007: Hokkaido University, Graduate school of Medicine, Assistant professor
2006: 北海道大学, 大学院医学研究科, 助手
2005: 北海道大学, 大学院・医学研究科, 助手
2002: 北大, 医学(系)研究科(研究院), 助手 Less
Review Section/Research Field
Principal Investigator
Neurosurgery / Complex Systems Disease Theory / Medical Physics and Radiological Technology / Human pathology / Experimental pathology / Experimental pathology
Except Principal Investigator
Biological Sciences / Basic Section 53050:Dermatology-related / Basic Section 56030:Urology-related / Digestive surgery … More / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 58010:Medical management and medical sociology-related / Basic Section 49020:Human pathology-related / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Laboratory medicine / Biomedical engineering/Biomaterial science and engineering / Pediatrics / Hematology / Experimental pathology / Orthopaedic surgery Less
Keywords
Principal Investigator
個別化治療 / 病理 / 遺伝子異常 / スクリーニング検査 / 遺伝子パネル検査 / 分子病理 / 次世代シーケンサー / がんゲノム医療 / 個別化診断 / ゲノム解析 … More / クリニカルシーケンス / 脳腫瘍 / メカノバイオロジー / 遺伝子プロファイル / 人に皮膚モデル / 良性・悪性 / 肉芽 / メカノセンサー / alpha-SMA / PDGFRbeta / 組織 / 臨床病理学的解析 / 圧負荷 / 細胞シート / 生体医工学 / 臨床 / 褥瘡 / 数理解析 / 画像処理 / 診断システム / 統合画像 / MRI / Immumoprofiling / Immunoprofiling / シグナル伝達分子 / 免疫染色 / Rac / 低分子量G蛋白 / 診断病理学 / NSAIDs / シグナル伝達 / 癌 / COX-2 … More
Except Principal Investigator
CRK / 前立腺癌 / シングルセル解析 / シグナル伝達 / 乳房外パジェット病 / 神経内分泌がん / 血液循環腫瘍細胞 / 次世代シーケンサー / リキッドバイオプシー / 個別化医療 / がんゲノム医療 / オルガノイド / SDF-1 / DOCK2 / SYT-SSX / 滑膜肉腫 / アダプター / 個別化治療 / 薬剤耐性 / 病態機構 / 遺伝子異常 / 腫瘍微小環境 / 薬剤耐性モデル / 異種移植モデル / 前臨床モデル / 大学・病院間連携 / RT-qPCR / 新型コロナウイルス / 検査システム / 医学部 / ダイアグラム / システム理論 / システム図 / 臨床検査 / パンデミック / 衛生検査所 / 組織構築 / フロー図 / システムズエンジニアリング / 新型コロナウイルス感染症 / PCR検査 / 免疫染色 / 免疫チェックポイント阻害剤 / がんゲノム / ICI / heterogeneity / 異所性リンパ組織 / 遺伝子変異量 / がん遺伝子パネル検査 / 病理 / がん免疫 / Heterogeneity / 遺伝子プロファイル / シークエンス / 血液循環がん細胞 / 腫瘍内不均一性 / 去勢抵抗性前立腺癌 / 硬さ / がん / 薬物感受性 / 組織工学 / 遺伝子発現 / 生物学的因子 / 物理化学的因子 / 三次元培養 / がん細胞 / 3Dオルガノイド法 / 薬剤感受性 / 癌遺伝子検査 / 遺伝子検査 / 3Dオルガノイド / 癌 / 薬剤スクリーニング / 癌ゲノム / 組織切片 / Padlock probe / mRNA / マイクロ流路 / DNA / マイクロデバイス / 遺伝子分析 / 灌流培養 / 間質 / 腫瘍 / 三次元組織 / 生理学 / プロスタグランディン / 循環器・高血圧 / プロスタグランディンE / 冠動脈 / リモデリング / 内膜肥厚 / 小児 / 動脈硬化 / Ramos cell / Chemotaxis / ナイーブB細胞 / メモリーB細胞 / 多発性骨髄腫 / リンパ増殖性疾患 / siRNA / ケモタキシス / Ramos細胞 / 細胞遊走 / 分子機能解析 / HCGβ / hCGβ / hCG β / 浸潤・転移 / EMT / 大腸癌 / リンパ管浸潤 / Mesothelin / mesothelin / cancer / mesotherin / 病理診断 / 分子標的薬 / スクリーニング / 化合物 / シグナル / 癌遺伝子 / Gabl / Knockout mouse / Gab1 / Crk / knockout mouse / ノックアウトマウス / トランスジェニックマウス / G蛋白質 / 細胞骨格 / NMR / 構造解析 / crk / ELMO1 / ユビキチン化 / DOCK180 Less
  • Research Projects

    (26 results)
  • Research Products

    (94 results)
  • Co-Researchers

    (50 People)
  •  乳房外パジェット病の腫瘍微小環境および遺伝子異常を基盤とした病態機構の解明と制御

    • Principal Investigator
      舩越 建
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Keio University
  •  Elucidation of the molecular control mechanism of refractory prostate cancer that includes lineage plasticity and establishment of individualized treatment strategies

    • Principal Investigator
      小坂 威雄
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  異種移植モデルを用いた乳房外パジェット病に対する新規治療法の開発

    • Principal Investigator
      柳 輝希
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      University of the Ryukyus
      Hokkaido University
  •  Analysis for heterogeneity of cancer genome profile

    • Principal Investigator
      Aimono Eriko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Keio University
  •  Building a versatile medical test system in a pandemic

    • Principal Investigator
      大場 純奈
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58010:Medical management and medical sociology-related
    • Research Institution
      Keio University
  •  Single-cell analysis of neuroendocrine prostate cancer to elucidate pathophysiology and establish novel treatment strategy

    • Principal Investigator
      Kosaka Takeo
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Keio University
  •  Physicochemical factors required for the maintenance of genetic information in clinical cancer and their application to personalized cancer care

    • Principal Investigator
      Matsusaki Michiya
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Osaka University
  •  Integrated analysis of ITH in drug resistant prostate cancer by single cell analysis

    • Principal Investigator
      Kosaka Takeo
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Keio University
  •  Development of a cancer genome personalized medicine screening system using the 3D organoid method.

    • Principal Investigator
      Takaishi Hiromasa
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Keio University
  •  Gene profiling for pressure ulcerPrincipal Investigator

    • Principal Investigator
      NISHIHARA Hiroshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Complex Systems Disease Theory
    • Research Institution
      Keio University
  •  Clinical Sequence Platform for Brain TumorPrincipal Investigator

    • Principal Investigator
      NISHIHARA Hiroshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Keio University
  •  Construction of flow culture system of 3D-Cancer-stromal Tissues for Evaluation of Interaction Between Cancer cells and Immunocytes

    • Principal Investigator
      Matsusaki Michiya
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Osaka University
  •  MRI-based PathoViewPrincipal Investigator

    • Principal Investigator
      NISHIHARA HIROSHI
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical Physics and Radiological Technology
    • Research Institution
      Hokkaido University
  •  Development of microdevice-based high throughput and high sensitivity in situ mRNA analysis method

    • Principal Investigator
      Sato Kae
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Japan Women's University
  •  Chorionic gonadotropin beta modulates epithelial-mesenchymal transition in human colorectal carcinoma metastasis

    • Principal Investigator
      Homma Shigenori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Hokkaido University
  •  Molecular Mechanisms of atherosclerotic remodeling in childhood

    • Principal Investigator
      YOKOYAMA Utako
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Yokohama City University
  •  Significance of Mesothelin expression in gastrointestinal cancer and relation with cancer malignancy

    • Principal Investigator
      KAMACHI Hirofumi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Hokkaido University
  •  滑膜肉腫幹細胞の同定と創薬基盤の確立

    • Principal Investigator
      田中 伸哉
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  癌浸潤におけるアダプター分子CRKの解析と構造に基づく治療薬開発への応用

    • Principal Investigator
      田中 伸哉
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Immunoprofiling of signaling molecule on malignant tumorPrincipal Investigator

    • Principal Investigator
      NISHIHARA Hiroshi
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Human pathology
    • Research Institution
      Hokkaido University
  •  Analysis of synovial sarcoma oncogene SYT-SSX for development of new therapy

    • Principal Investigator
      TANAKA Shinya
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hokkaido University
  •  ヒト癌浸潤におけるアダプター分子クラックの解析

    • Principal Investigator
      田中 伸哉
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  The study to investigate mechanisms of B-cell homing to the microenvironment via DOCK2 and implications to the therapy far hematological malignancies

    • Principal Investigator
      MITSUFUMI Nishio
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Hokkaido University
  •  癌浸潤に関与するユビキチン化を生細胞で時間的空間的に解析する

    • Principal Investigator
      TANAKA Shinya
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  非ステロイド系抗炎症剤による抗腫瘍機序を解明し、腫瘍の悪性度判定法を確立するPrincipal Investigator

    • Principal Investigator
      西原 広史
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  ヒト腫瘍の浸潤・転移に関するRac及びCDM-ファミリー蛋白の機能の解析Principal Investigator

    • Principal Investigator
      西原 広史
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University

All 2023 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft2023

    • Author(s)
      Hsu Che-Yuan、Yanagi Teruki、Maeda Takuya、Nishihara Hiroshi、Miyamoto Kodai、Kitamura Shinya、Tokuchi Keiko、Ujiie Hideyuki
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 8650-8650

    • DOI

      10.1038/s41598-023-35811-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08397, KAKENHI-PROJECT-23K07757
  • [Journal Article] Germline BRCA2 mutation in a case of aggressive prostate cancer accompanied by spinal bulbar muscular atrophy2022

    • Author(s)
      Kosaka Takeo、Hongo Hiroshi、Hayashi Hideyuki、Nakamura Kohei、Nishihara Hiroshi、Mikami Shuji、Beltran Himisha、Oya Mototsugu
    • Journal Title

      Asian Journal of Andrology

      Volume: 24 Issue: 1 Pages: 116-116

    • DOI

      10.4103/aja.aja_37_21

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-20K18232
  • [Journal Article] Characterizing cyclin-dependent kinase 12(CDK12)-altered aggressive prostate cancer: a twelve-case series2022

    • Author(s)
      Iwasawa Tomohiro、Kosaka Takeo、Yasumizu Yota、Hongo Hiroshi、Yanai Yoshinori、Baba Yuto、Matsumoto Kazuhiro、Nakamura Kohei、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 27 Issue: 12 Pages: 1867-1873

    • DOI

      10.1007/s10147-022-02248-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K19579
  • [Journal Article] SARS-CoV-2 RT-qPCR testing of pooled saliva samples: A case study of 824 asymptomatic individuals and a questionnaire survey in Japan2022

    • Author(s)
      Oba Junna、Taniguchi Hiroaki、Sato Masae、Takanashi Masaki、Yokemura Moe、Sato Yasunori、Nishihara Hiroshi
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 5 Pages: e0263700-e0263700

    • DOI

      10.1371/journal.pone.0263700

    • Data Source
      KAKENHI-PROJECT-21K10334
  • [Journal Article] Influence of response to prior docetaxel on sensitivity to cabazitaxel in prostate cancer patients with PTEN alterations2022

    • Author(s)
      Kamisawa Ken、Kosaka Takeo、Nakamura Kohei、Yasumizu Yota、Hongo Hiroshi、Takeda Toshikazu、Matsumoto Kazuhiro、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 9 Pages: 3161-3168

    • DOI

      10.1111/cas.15473

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-21K19579
  • [Journal Article] The first Japanese case of intraductal cancer of the prostate with checkpoint kinase 2 mutation2022

    • Author(s)
      Hongo Hiroshi、Kosaka Takeo、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Asian Journal of Urology

      Volume: 9 Issue: 4 Pages: 480-482

    • DOI

      10.1016/j.ajur.2022.02.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09436, KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-21K19579
  • [Journal Article] Genomic analysis of aggressive ductal adenocarcinoma of the prostate2022

    • Author(s)
      Kobayashi Hiroaki、Kosaka Takeo、Nakamura Kohei、Kimura Tokuhiro、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Cancer Medicine

      Volume: 12 Issue: 7 Pages: 8445-8451

    • DOI

      10.1002/cam4.5573

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
  • [Journal Article] Squamous cell carcinoma of the prostate with SMARCA4 alteration in a Japanese patient2022

    • Author(s)
      Kaneko Yuta、Kosaka Takeo、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 5 Issue: 5 Pages: 323-326

    • DOI

      10.1002/iju5.12466

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468
  • [Journal Article] Prominent response to platinum‐based chemotherapy in a patient with BRCA2 mutant‐neuroendocrine prostate cancer and MDM2 amplification2021

    • Author(s)
      Daimon Tatsuaki、Kosaka Takeo、Hongo Hiroshi、Aimono Eriko、Nakamura Kohei、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 4 Issue: 4 Pages: 216-219

    • DOI

      10.1002/iju5.12287

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
  • [Journal Article] First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations2021

    • Author(s)
      Omura Minami、Kosaka Takeo、Aimono Eriko、Nakamura Kohei、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 5 Issue: 1 Pages: 41-44

    • DOI

      10.1002/iju5.12383

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-20K18232
  • [Journal Article] RT-PCR Screening Tests for SARS-CoV-2 with Saliva Samples in Asymptomatic People: Strategy to Maintain Social and Economic Activities while Reducing the Risk of Spreading the Virus2021

    • Author(s)
      Junna Oba, Hiroaki Taniguchi, Masae Sato, Reika Takamatsu, Satoru Morikawa, Taneaki Nakagawa, Hiromasa Takaishi, Hideyuki Saya, Koichi Matsuo, Hiroshi Nishihara
    • Journal Title

      The Keio Journal of Medicine

      Volume: 70 Issue: 2 Pages: 35-43

    • DOI

      10.2302/kjm.2021-0003-OA

    • NAID

      130008056626

    • ISSN
      0022-9717, 1880-1293
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K10334
  • [Journal Article] A first case of ductal adenocarcinoma of the prostate having characteristics of neuroendocrine phenotype with PTEN, RB1 and TP53 alterations2021

    • Author(s)
      Kobayashi Hiroaki、Kosaka Takeo、Nakamura Kohei、Shojo Kazunori、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      BMC Medical Genomics

      Volume: 14 Issue: 1 Pages: 1-4

    • DOI

      10.1186/s12920-021-01093-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19579
  • [Journal Article] First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion2021

    • Author(s)
      Shojo Kazunori、Kosaka Takeo、Nakamura Kohei、Hongo Hiroshi、Kobayashi Hiroaki、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 4 Issue: 3 Pages: 176-179

    • DOI

      10.1002/iju5.12274

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
  • [Journal Article] A first Japanese case of BRCA2 and RB1 co-loss organ-confined prostate cancer successfully treated by radical prostatectomy2021

    • Author(s)
      Matsumoto Kazuhiro、Kosaka Takeo、Nakamura Kohei、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      International Cancer Conference Journal

      Volume: 10(3) Issue: 3 Pages: 170-173

    • DOI

      10.1007/s13691-021-00469-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-20K18232
  • [Journal Article] Intratumoral Genomic Heterogeneity May Hinder Precision Medicine Strategies in Patients with Serous Ovarian Carcinoma2020

    • Author(s)
      Nakamura Kohei、Aimono Eriko、Tanishima Shigeki、Imai Mitsuho、Nagatsuma Akiko Kawano、Hayashi Hideyuki、Yoshimura Yuki、Nakayama Kentaro、Kyo Satoru、Nishihara Hiroshi
    • Journal Title

      Diagnostics

      Volume: 10 Issue: 4 Pages: 200-200

    • DOI

      10.3390/diagnostics10040200

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0046, KAKENHI-PROJECT-17K10855, KAKENHI-PROJECT-17K16851, KAKENHI-PROJECT-20K18232
  • [Journal Article] CDK12 and HER2 coamplification in two urothelial carcinomas with rapid and aggressive clinical progression2020

    • Author(s)
      Yanai Yoshinori、Kosaka Takeo、Nakamura Kohei、Aimono Eriko、Matsumoto Kazuhiro、Morita Shinya、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 12 Pages: 4652-4655

    • DOI

      10.1111/cas.14672

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
  • [Journal Article] Pulmonary metastasis secondary to abiraterone‐resistant prostate cancer with homozygous deletions of BRCA2: First Japanese case2020

    • Author(s)
      Izawa Mizuki、Kosaka Takeo、Nakamura Kohei、Oba Junna、Hishida Tomoyuki、Hongo Hiroshi、Mikami Shuji、Nishihara Hiroshi、Oya Mototsugu
    • Journal Title

      IJU Case Reports

      Volume: 4 Issue: 1 Pages: 14-17

    • DOI

      10.1002/iju5.12224

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-20K18232, KAKENHI-PROJECT-20H03817
  • [Journal Article] Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness2019

    • Author(s)
      Tanaka Hiroyoshi Y.、Kitahara Kentaro、Sasaki Naoki、Nakao Natsumi、Sato Kae、Narita Hirokazu、Shimoda Hiroshi、Matsusaki Michiya、Nishihara Hiroshi、Masamune Atsushi、Kano Mitsunobu R.
    • Journal Title

      Biomaterials

      Volume: 192 Pages: 355-367

    • DOI

      10.1016/j.biomaterials.2018.11.023

    • NAID

      120006900803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H02099, KAKENHI-PROJECT-18H02797
  • [Journal Article] Cancer gene profiling explores the possible precision medicine for diffuse-type gastric adenocarcinoma2019

    • Author(s)
      Ishikawa M, Hayashi H, Sakamoto N, Tanaka S, Nishihara H
    • Journal Title

      Med Oncol.

      Volume: 37(1) Issue: 1 Pages: 10-10

    • DOI

      10.1007/s12032-019-1327-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17KT0046, KAKENHI-PROJECT-17K10855
  • [Journal Article] Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors2019

    • Author(s)
      Sonoda Yukihiko、The committee for molecular diagnosis of the Japan Society of Brain Tumor Pathology、Yokoo Hideaki、Tanaka Shinya、Kinoshita Manabu、Nakada Mitsutoshi、Nishihara Hiroshi
    • Journal Title

      Brain Tumor Pathology

      Volume: in press Issue: 2 Pages: 56-62

    • DOI

      10.1007/s10014-019-00337-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10778, KAKENHI-PUBLICLY-17H05308, KAKENHI-PROJECT-17K10855
  • [Journal Article] In vitro 3D blood/lymph-vascularized human stromal tissues for preclinical assays of cancer metastasis2018

    • Author(s)
      Nishiguchi Akihiro、Matsusaki Michiya、Kano Mitsunobu R.、Nishihara Hiroshi、Okano Daisuke、Asano Yoshiya、Shimoda Hiroshi、Kishimoto Satoko、Iwai Soichi、Akashi Mitsuru
    • Journal Title

      Biomaterials

      Volume: 179 Pages: 144-155

    • DOI

      10.1016/j.biomaterials.2018.06.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H00864, KAKENHI-PROJECT-17H02099, KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-17K08506
  • [Journal Article] Importance of luminal membrane mesothelin expression in intraductal papillary mucinous neoplasms.2015

    • Author(s)
      Einama T, Kamachi H, Nishihara H, Homma S, Kanno H, Ishikawa M, Kawamata F, Konishi Y, Sato M, Tahara M, Okada K, Muraoka S, Kamiyama T, Taketomi A, Matsuno Y, Furukawa H, Todo S.
    • Journal Title

      Oncol Lett.

      Volume: 9(4) Pages: 1583-1589

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592017
  • [Journal Article] The Significance of Luminal Membrane Mesothelin Expression in Intraductal Papillary Mucinous Neoplasms2014

    • Author(s)
      Takahiro Einama, Hirofumi Kamachi, Hiroshi Nishihara, Shigenori Homma, Hiromi Kanno, Marin Ishikawa, Futoshi Kawamata, Yuji Konishi, Masanori Sato, Munenori Tahara, Kuniaki Okada, Shunji Muraoka, Toshiya Kamiyama, Akinobu Taketomi, Yoshihiro Matsuno, Satoru Todo
    • Journal Title

      Oncology Letters

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592017
  • [Journal Article] Expression of O6-methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors.2012

    • Author(s)
      Kanno, H.,Nishihara, H.,Oikawa, M.,Ozaki, Y.,Murata, J.,Sawamura, Y.,Kato, M.,Kubota, K.,Tanino, M. Kimura, T.,Nagashima, K.,Itoh, T.,Tanaka, S.
    • Journal Title

      Neuropathology

      Volume: 32 Issue: 6 Pages: 647-653

    • DOI

      10.1111/j.1440-1789.2012.01315.x

    • NAID

      120005356854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390089, KAKENHI-PROJECT-23791621, KAKENHI-PROJECT-24590406, KAKENHI-PROJECT-24659173, KAKENHI-PROJECT-24790341
  • [Journal Article] CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma2012

    • Author(s)
      Kimura, T.,Wang, L.,Tabu, K.,Nishihara, H.,Mashita, Y.,Kikuchi, N.,Tanino, M.,Hiraga, H.,Tanaka, S.
    • Journal Title

      Cancer invest

      Volume: 30 Pages: 390-397

    • NAID

      120005228733

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Journal Article] CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion.2012

    • Author(s)
      Yanagi, H.,Wang , L.,Nishihara, H.,Kimura, T.,Tanino, M.,Yanagi, T.,Fukuda, S.,Tanaka, S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 418 Pages: 104-109

    • NAID

      120005183147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Journal Article] CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma.2012

    • Author(s)
      Kimura, T.,Wang, L.,Tabu, K.,Nishihara, H.,Mashita, Y.,Kikuchi, N.,Tanino, M.,Hiraga, H.,Tanaka, S.
    • Journal Title

      Cancer invest

      Volume: 30 Pages: 390-397

    • NAID

      120005228733

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Journal Article] Prognostic implication of histological oligodendroglial tumor component: clinicopathological analysis of 111 cases of malignant gliomas.2012

    • Author(s)
      Kanno, H.,Nishihara, H.,Narita, T.,Yamaguchi, S.,Kobayashi, H.,Tanino, M.,Kimura, T.,Terasaka S.,Tanaka, S.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 7 Pages: e41669-e41669

    • DOI

      10.1371/journal.pone.0041669

    • NAID

      120004650825

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390089, KAKENHI-PROJECT-23791621, KAKENHI-PROJECT-24590406
  • [Journal Article] STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression.2012

    • Author(s)
      Kohsaka, S., Wang, L.,Yachi, K.,Mahabir, R.,Narita, T.,Itoh, T.,Tanino, M.,Kimura, T.,Nishihara,H.,Tanaka, S
    • Journal Title

      Mol Cancer Ther

      Volume: 11 Pages: 1289-1299

    • NAID

      120005228738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Journal Article] STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expression.2012

    • Author(s)
      Kohsaka, S., Wang, L.,Yachi, K.,Mahabir, R.,Narita, T.,Itoh, T.,Tanino, M.,Kimura, T.,Nishihara H.,Tanaka, S.
    • Journal Title

      Mol Cancer Ther.

      Volume: 11 Pages: 1289-1299

    • NAID

      120005228738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Journal Article] DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma.2010

    • Author(s)
      Wang L, Nishihara H, Kimura T, Kato Y, Tanino M, Nishio M, Obara M, Endo T, Koike T, Tanaka S
    • Journal Title

      Biochem Biophys Res Commun (Epub ahead of print)

    • NAID

      120002148671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Journal Article] Sudden death of a patient with pandemic influenza (A/H1N1pdm) virus infection by acute respiratory distress syndrome.2010

    • Author(s)
      Takiyama A, Wang L, Tanino M, Kimura T, Kawagishi N, Kunieda Y, Katano H, Nakajima N, Hasegawa H, Takagi T, Nishihara H, Sata T, Tanaka S
    • Journal Title

      Jpn J Infect Dis 63(1)

      Pages: 72-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Journal Article] Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks.2010

    • Author(s)
      Tabu K, Kimura T, Sasai K, Wang L, Bizen N, Nishihara H, Taga T, Tanaka S
    • Journal Title

      Mol Cancer 9(1)

      Pages: 39-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Journal Article] Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration.2009

    • Author(s)
      Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, Sawa H, Nagashima K, Nishihara H, Hatakeyama S, Nakayama K, Ladanyi M, Tanaka S, Nakayama KI
    • Journal Title

      Lab Invest 89(6)

      Pages: 645-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Journal Article] A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings.2009

    • Author(s)
      Nishihara H, Nakasato M, Sawa H, Murakami H, Yamamoto D, Moriyama K, Kato N, Hashimoto I, Kamada H, Tanaka S
    • Journal Title

      J Neurooncol 93(2)

      Pages: 275-8

    • Data Source
      KAKENHI-PROJECT-20689010
  • [Journal Article] Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration2009

    • Author(s)
      Watanabe, T., Tsuda, M., Makino, Y., Konstantinou T., Nishihara, H., Majima, T., Minami, A., Feller, SM., Tanaka, S
    • Journal Title

      Cell Res 19

      Pages: 638-650

    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.2009

    • Author(s)
      Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S
    • Journal Title

      Cell Res. 19(5)

      Pages: 638-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Journal Article] Lab. Invest2009

    • Author(s)
      Kimura, T., Sakai, M., Tabu, K., Wang. L., Tsunematsu, R., Tsuda, M., Sawa, H., Nagashima, K., Nishihara, H., Hatakeyama, S., Nakayama, K., Ladanyi, M., Tanaka, S., Nakayama, KI
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] A case of central nervous system lymphomatoid granulomatosis ; characteristics of PET imaging and pathological findings2009

    • Author(s)
      Nishihara H
    • Journal Title

      J Nerooncol 93

      Pages: 275-278

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013001
  • [Journal Article] A case of central nervous system lymphomatoid granulomatosis ; characteristics of PET imaging and pathological findings.2009

    • Author(s)
      Nishihara H
    • Journal Title

      J Nerooncol 93

      Pages: 275-278

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Harlequin ichthyosis model mouse reveals alveolar aollapse and severe fetal skin barrier defects2008

    • Author(s)
      Yanagi, T., Akiyama, M., Nishihara, H., Sakai, K. Nishie, W., Tanaka, S., Shimizu, H
    • Journal Title

      Human Mol. Genetics 17

      Pages: 3075-3083

    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Promoter hypomethylation regulates CD133 expression in human gliomas2008

    • Author(s)
      Tabu, K., Sasai, K., Kimura, T., Wang, L., Aoyanagi, E., Kohsaka, S., Tanino, M., Nishihara, H., Tanaka, S
    • Journal Title

      Cell Res 18

      Pages: 1037-1046

    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methy lguanine-DNA methyltransferase status in glioma2008

    • Author(s)
      Sasai, K., Nodagashira, M., Nishihara, H., Aoyanagi, E., Wang, L., Katoh, M., Murata, J., Ozaki, Y., Ito, T., Fujimoto, S., Kaneko, S., Nagashima, K., Tanaka, S
    • Journal Title

      Am. J. Surg. Pathol 32

      Pages: 1220-1227

    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis.2007

    • Author(s)
      Nishihara, H, Tateishi, U., Itoh, T., Nagashima, K., and Tanaka, S.
    • Journal Title

      Neuropathology 27

      Pages: 413-418

    • NAID

      10021236336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Immunohistochemical and gene rearrangement studies of central nervous system lymphomatoid granulomatosis.2007

    • Author(s)
      Nishihara, H., Tateishi, U., Itoh, T., Nagashima, K., Tanaka, S.
    • Journal Title

      Neuropathology 27

      Pages: 413-418

    • NAID

      10021236336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18013003
  • [Journal Article] Type I interferon prolongs cell cycle progression via p21 WAF1/CIP1 induction in human colon cancer cells.2007

    • Author(s)
      Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., and Todo, S.
    • Journal Title

      International Journal of oncology 31

      Pages: 613-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Signaling adaptor protein Crk is indispensable for malignant feature of gliblastoma cell line KMG4.2007

    • Author(s)
      Wang, L., Tabu, K., Kimura, T., Tsuda, M., Linghu, H., Tanino, M., Kaneko, S., Nishihara, H., Tanaka, S.
    • Journal Title

      Biochem Biophys Res Commun 362

      Pages: 976-981

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18013003
  • [Journal Article] Type I interferon prolongs cell cycle progression via p21 WAF1/CIP1 induction in human colon cancer cells2007

    • Author(s)
      Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., Todo, S
    • Journal Title

      Int. J. Oncol 31

      Pages: 613-620

    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Type I interferon prolongs cell cycle progression via p21 WAF1/CIP1 induction in human colon cancer cells.2007

    • Author(s)
      Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., Todo, S.
    • Journal Title

      International Journal of oncology 31

      Pages: 613-620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18013003
  • [Journal Article] Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG42007

    • Author(s)
      Wang, L., Tabu, K., Kimura, T., Tsuda, M., Linghu, H., Tanino, M., Kaneko, S., Nishihara, H., Tanaka, S
    • Journal Title

      Biochem Biophys Res Commun 362

      Pages: 976-98

    • NAID

      120000955825

    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4.2007

    • Author(s)
      Wang, L., Tabu, K., Kimura, T., Tsuda, M., Linghu, H., Tanino, M., Kaneko, S., Nishihara, H., Tanaka, S.
    • Journal Title

      Biochem Biophys Res Commun 362

      Pages: 976-981

    • NAID

      120000955825

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] Immunohistochemical and Gene Rearrangement Studies of Central Nervous System Lymphomatoid Granulomatosis2007

    • Author(s)
      Nishihara, H., Tateishi, U., Itoh, T., Nagashima, K., Tanaka, S
    • Journal Title

      Neuropathology 27

      Pages: 413-417

    • NAID

      10021236336

    • Data Source
      KAKENHI-PROJECT-19390386
  • [Journal Article] DOCK2 regulates cell proliferation through Rae and ERK activation in B cell lymphoma

    • Author(s)
      Wang L, Nishihara H, et.al
    • Journal Title

      Biochemical and Biophysical Research Communications (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] 神経膠腫におけるスクリーニング癌遺伝子パネル検査の有用性2023

    • Author(s)
      四十物絵理子、西原広史
    • Organizer
      第113回日本病理学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06895
  • [Presentation] がんゲノム医療におけるドライバー遺伝子異常評価システムの開発2023

    • Author(s)
      四十物絵理子、西原広史
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06895
  • [Presentation] ゲノム診断における病理医の関与(遺伝子パネル検査における病理医の重要性)2018

    • Author(s)
      西原 広史
    • Organizer
      第107回日本病理学会総会 ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10855
  • [Presentation] “PleSSision”; a Pathologist edited Multigene Genomic Test promotes Cancer Precision Medicine.2018

    • Author(s)
      Hiroshi Nishihara
    • Organizer
      The 11th International Conference of Clinical Laboratory Automation and Robotics; Cherry Blossom Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10855
  • [Presentation] ターゲットシーケンスによる神経膠腫の1p19q codel検出2017

    • Author(s)
      西原広史
    • Organizer
      第76回日本癌学会学術総会 腫瘍別シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K10855
  • [Presentation] Intraductal papillary mucinous neoplasms(IPMNs)におけるMesothelin発現様式の検討2014

    • Author(s)
      永生 高広, 蒲池 浩文, 西原 広史, 本間 重紀, 田原 宗徳, 岡田 邦明, 村岡 俊二, 神山 俊哉, 松野 吉宏, 谷口 雅彦, 古川 博之, 武富 紹信, 藤堂 省
    • Organizer
      第114回日本外科学会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都)
    • Data Source
      KAKENHI-PROJECT-24592017
  • [Presentation] Prostaglandin E2-EP4 signaling promotes secretion of the lipid-relating proteoglycan biglycan in human coronary arteries during development2013

    • Author(s)
      Kumagaya S, Yokoyama U, Sato A, Nishihara H, Inoue T, Minamisawa S, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都渋谷区)
    • Data Source
      KAKENHI-PROJECT-25293236
  • [Presentation] Molecular and clinicopathological analysis for ERC/Mesothelin in digestive cancers2013

    • Author(s)
      西原広史、川俣太、永生高広、津田真寿美、王磊、樋野興夫、武冨紹信、田中伸哉
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Data Source
      KAKENHI-PROJECT-24592017
  • [Presentation] 消化器癌におけるERC/mesothelin発現の分子病理学的解析2013

    • Author(s)
      西原広史、川俣太、永生高広、加藤容崇、樋野興夫、武冨紹信、田中伸哉
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌・さっぽろ文芸館(札幌)
    • Data Source
      KAKENHI-PROJECT-24592017
  • [Presentation] 細胞内の局在に着目した肝外胆管癌におけるMesothelin発現の免疫組織学的検討2013

    • Author(s)
      川俣 太, 蒲池 浩文, 永生 高広, 西原 広史, 田原 宗徳, 神山 俊哉, 藤堂 省, 武冨 紹信
    • Organizer
      第25回日本肝胆膵外科学会
    • Place of Presentation
      ホテル東日本宇都宮(栃木)
    • Data Source
      KAKENHI-PROJECT-24592017
  • [Presentation] Clinicopathological analysis for angiocentric, angiodestructive lymphoproliferative disorder of central nervous system2012

    • Author(s)
      Hiroshi Nishihara, Teruki Yanagi and Shinya Tanaka
    • Organizer
      17th Annual Scientific Meeting and Education Day of the Society for Neuro-oncology
    • Place of Presentation
      Washington DC Hilton Hotel (USA)
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Presentation] Clinicopathological analysis for angiocentric, angiodestructive lymphoproliferative disorder of central nervous system2012

    • Author(s)
      Hiroshi Nishihara, Teruki Yanagi and Shinya Tanaka
    • Organizer
      17th Annual Scientific Meeting and Education Day of the Society for Neuro-oncology
    • Place of Presentation
      Washington DC HIlton Hotel(USA)
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Presentation] Identification and analysis of synovial sarcoma initiating cells.2012

    • Author(s)
      Taichi Kimura, Lei Wang, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka
    • Organizer
      Cold Spring Harbor Laboratory Meeting; Mechanisms and Models of Cancer
    • Place of Presentation
      Cold Spring Harbor Laboratory(USA)
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Presentation] Prognostic PDGFR-beta expression in tumor stroma of pancreatic adenocarcinoma.2012

    • Author(s)
      Hiroshi Nishihara, Sayaka Yuzawa, Mitsunobu Kano, Shinya Tanaka
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Presentation] Molecular and pathological analysis of malignant glioma: from tissues to therapeutic reagents2012

    • Author(s)
      Shinya Tanaka, Shinji Kohsaka, Kouich Tabu, Lei Wang, Masumi Tsuda, Taichi Kimura, Mishie Tanino, Hiroshi Nishihara, Hiromichi Kimura
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Presentation] dentification and analysis of synovial sarcoma initiating cells.2012

    • Author(s)
      Taichi Kimura, Lei Wang, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka
    • Organizer
      Cold Spring Harbor Laboratory Meeting; Mechanisms and Models of Cancer
    • Place of Presentation
      Cold Spring Harbor laboraory(USA)
    • Data Source
      KAKENHI-PROJECT-23390089
  • [Presentation] 髄膜腫におけるDOCK180の発現の検討2009

    • Author(s)
      西原広史、村上普美、木村憲一、佐和弘基、鎌田一、田中伸哉
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      高松
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] 中枢神経発症のリンパ腫様肉芽腫症は、T細胞リンパ腫の初期病変である2009

    • Author(s)
      Hiroshi Nishihara
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] Pathological analysis for cancer-mesenchymal and vascular structure associated with drug delivery system.2009

    • Author(s)
      西原広史
    • Organizer
      第25回日本DDS学会学術集会ワークショップDDSとがん組織(間質、脈管)
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] OCK180はHodgkin細胞に発現し、細胞の形態制御に重要な役割を果たしている2009

    • Author(s)
      王磊、西原広史、田中伸哉
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] 中枢神経発症のリンパ腫様肉芽腫症は、T細胞リンパ腫の初期病変である2009

    • Author(s)
      西原広史
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20013001
  • [Presentation] 脳腫瘍血管壁の組織病理学的解析:Glomeruloid vesselは肥厚した幼若なPericyteで構成されている2009

    • Author(s)
      西原広史
    • Organizer
      第27回日本脳腫瘍病理学会
    • Place of Presentation
      福岡 アクロス福岡
    • Year and Date
      2009-05-08
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] 脳腫瘍血管壁の組織病理学的解析: Glomeruloid vessel は肥厚した幼若な Pericyte で構成されている2009

    • Author(s)
      西原広史
    • Organizer
      第27回日本脳腫瘍病理学会
    • Place of Presentation
      福岡 アクロス福岡
    • Year and Date
      2009-05-08
    • Data Source
      KAKENHI-PROJECT-20013001
  • [Presentation] 髄膜腫におけるDOCK180の発現の検討2009

    • Author(s)
      西原広史
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      香川 サンポート香川、かがわ国際会議場
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] 悪性膠腫におけるCD133発現の分子細胞病理学的解析2009

    • Author(s)
      椨康一、笹井研、木村太一、谷野美智枝、青柳瑛子、王磊、高阪真路、西原広史、田中伸哉
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] MDS患者のリンパ節に発生したtrilineage extramedullary myeloid cell tumorの1例2009

    • Author(s)
      西原広史、高阪真路、久保田佳奈子、田中伸哉、松野吉宏
    • Organizer
      第49回日本リンパ網内系学会総会
    • Place of Presentation
      淡路島
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] 髄膜腫におけるDOCK180の発現の検討2009

    • Author(s)
      西原広史
    • Organizer
      第50回日本神経病理学会
    • Place of Presentation
      香川 サンポート香川、かがわ国際会議場
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-20013001
  • [Presentation] FRETバイオセンターを用いたCML分子標的薬剤の薬効評価系の構築2009

    • Author(s)
      西原広史
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜パシフィコ横浜
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-20013001
  • [Presentation] Clinicopathological analysis for glioma-specific vascular structures.2009

    • Author(s)
      Hiroshi Nishihara, Mitsunobu R. Kano, Hiromi Kanno, Shinya Tanaka
    • Organizer
      AACR Special Conference on Genetics and Biology of Brain Cancers
    • Place of Presentation
      アメリカ、サンディエゴ
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] ヒト腫瘍間質・血管の実際2009

    • Author(s)
      西原広史
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京 東京ドームホテル
    • Year and Date
      2009-07-03
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] 脳腫瘍血管壁の組織病理学的解析:Glomeruloid vesselは肥厚した幼若なPericyteで構成されている2009

    • Author(s)
      西原広史、狩野光伸、田中伸哉
    • Organizer
      第27回日本脳腫瘍病理学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] CNS-lymphomatoid granulomatosis; as a primary lesion for CNS-T cell lymphoma2009

    • Author(s)
      Hiroshi Nishihara, Kazuo Nagashima, Shinya Tanaka
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] 髄膜腫におけるDOCK180の発現の検討2009

    • Author(s)
      西原広史、村上普美、木村憲一、佐和弘基、鎌田一、田中伸哉
    • Organizer
      第50回日本神経病理学会学術研究会
    • Place of Presentation
      香川
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] GlioblastomaにおけるCD133の発現の免疫組織学的解析2009

    • Author(s)
      田中伸哉、大森優子、椨康一、野田頭未歩、青柳瑛子、伊藤民雄、中村博彦、西原広史、笹井研
    • Organizer
      第27回日本脳腫瘍病理学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] 悪性膠腫におけるMGMT発現の病理組織学的解析2008

    • Author(s)
      野田頭未歩、青柳瑛子、笹井研、王磊、西原広史、長嶋和郎、田中伸哉
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] 胸膜中皮腫におけるシグナルアダプター分子CRKの役割の解析2008

    • Author(s)
      谷野美智枝、王磊、西原広史、松野吉宏、矢野聖二、曽根三郎、田中伸哉
    • Organizer
      第48回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] Pilomyxoid patternを示すAnaplastic oligoastrocytoma (AOA)の病理学的検討2008

    • Author(s)
      西原広史、長嶋和郎、田中伸哉
    • Organizer
      第26回日本脳腫瘍病理学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] MGMT発現評価は病理組織学的に腫瘍と非腫瘍成分を識別することが重要である2008

    • Author(s)
      田中伸哉、野田頭未歩、青柳瑛子、加藤正仁、村田純一、伊東民雄、尾崎義丸、藤本真、金子貞夫、西原広史、笹井研、長嶋和郎
    • Organizer
      第26回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] 悪性膠腫におけるMGMT発現の解析:免疫染色法とメチル化特異的PCR法の比較.2008

    • Author(s)
      田中伸哉、野田頭未歩、青柳瑛子、王磊、西原広史、長嶋和郎、笹井研
    • Organizer
      第49回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390386
  • [Presentation] Paul A. Insel. Cyclic AMP-dependent regulation of colon cancer growth and apoptosis: A key role for COX-22008

    • Author(s)
      Hiroshi Nishihara, Hiroshi Yokouchi, Shinya Tanaka, Lars Eckmann
    • Organizer
      AACR (American Society of Cancer Research)
    • Place of Presentation
      アメリカ、サンディエゴ
    • Data Source
      KAKENHI-PROJECT-20689010
  • [Presentation] NSAIDsによる抗腫瘍機序の解明:cAMPはCOX-2の発現を抑制し、大腸癌細胞の増殖を促進する2007

    • Author(s)
      西原 広史
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-17689017
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