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Konno Hiroyuki  今野 博行

ORCIDConnect your ORCID iD *help
… Alternative Names

KONNO Hiroyuki  今野 博行

ONOZUKA Mari

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Researcher Number 50325247
Other IDs
External Links
Affiliation (Current) 2025: 山形大学, 大学院理工学研究科, 教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 山形大学, 大学院理工学研究科, 教授
2018 – 2019: 山形大学, 大学院理工学研究科, 教授
2017: 山形大学, 理工学研究科, 教授
2016 – 2017: 山形大学, 大学院理工学研究科, 准教授
2012 – 2015: 山形大学, 理工学研究科, 准教授 … More
2009 – 2012: Yamagata University, 大学院・理工学研究科, 准教授
2008: Kyoto Prefectural University of Medicine, 大学院・医学研究科, 助教
2006 – 2008: 京都府立医科大学, 医学研究科, 助教
2007: Kyoto Pref. Univ. Med., Grad. Sch. Med. Sci., Assistant Prof.
2004 – 2006: 京都府立医科大学, 医学研究科, 助手
2002 – 2003: 徳島大学, 工学部, 助手 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / Bioorganic chemistry / Medium-sized Section 38:Agricultural chemistry and related fields / Chemical pharmacy
Except Principal Investigator
Basic Section 48020:Physiology-related / Chemical pharmacy / Basic Section 38040:Bioorganic chemistry-related / Environmental and hygienic pharmacy / Applied microbiology / Respiratory organ internal medicine / Applied biochemistry
Keywords
Principal Investigator
異常アミノ酸 / 細胞毒性 / 蛍光プローブ / TAK779 / 固相合成法 / 立体制御合成 / カリペルチン / 固相合成 / 不斉合成 / アジリジン … More / システインプロテアーゼ阻害剤 / 二次構造制御 / 分子認識 / 蛋白質ラベリング技術 / ラジカル酸化反応 / 可逆的アミノ基検出技術 / 薬物動態 / 活性酸素除去 / アルドール縮合 / フラン誘導体 / クルクミンダイマー / フラノン誘導体 / 構造活性相関 / 凝集阻害 / ドッキングシミレーション / ラジカルスカベンジャー / 水溶性 / クルクミン / 蛍光検出剤 / 凝集阻害剤 / アミロイドβ / 固相ペプチド合成 / ホモフィミン / マクロラクトン化反応 / TAK779誘導体 / HEK/CCR5 / 蛍光標識化 / ペプチド固相合成法 / CCR5阻害剤 / 環状デプシペプチド / 海綿産天然物 / 原蛋白質 / CCR5 / HIVウイルス / 抗HIV活性 / ジメチルグルタミン / callipeltin B / ケモカインレセプター / 抗 HIV活性 / 環状ペプチド / 抗HIV / 有機化学 / 生理活性 / 生体分子 / ウイルス / 合成化学 / 医薬品化学 / システインプロテアーゼ阻害 / カテプシンD / 天然有機化合物 / 海綿 / カテプシンB / ペプチド / 立体選択的合成 / 超原子価試薬 / スタチン / アルドール反応 / 遷移状態アナログ / ペンタペプチド / 全合成 / ペプチドミミック … More
Except Principal Investigator
COPD / SCGB3A2 / 阻害剤 / SARS / ペプチド / STAT / チアミン / マクロファージ / Decahydroisoquinoline / Fused ring scaffold / Inhibitor / SARS 3CL protease / デカヒドロイソキノリン / SARS 3CLプロテアーゼ / COVID-19 / 呼吸器疾患 / 感染 / PnuT / トランスポーター / ヘリコバクター・ピロリ / 結晶構造解析 / ニゲロオリゴ糖 / 転移反応 / α-1,3-グルカナーゼ / STAT3 / STAT1 / A1AT / 肺気腫 / aziridine / miraziridine A / inhibitor / 3CL-protease / Tokaramide A / アジリジン / Miraziridine A / 3CLプロテアーゼ / keratinocvte / genomic analysis / ultra violet / toxicology / cosmetic additives / 酵母 / 転写調節 / 情報伝達 / チアミンピロリン酸 / プロテアーゼ / Retro-Inverso / Dアミノ酸 / 構造解析 / プロテアーゼ阻害剤 / HTLV-1 Less
  • Research Projects

    (16 results)
  • Research Products

    (193 results)
  • Co-Researchers

    (14 People)
  •  次世代のCOPD治療を実現するSCGB3A2ペプチド薬の開発

    • Principal Investigator
      黒谷 玲子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48020:Physiology-related
    • Research Institution
      Yamagata University
  •  Reversible detection of amino group and protein labeling methodologyPrincipal Investigator

    • Principal Investigator
      今野 博行
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      Yamagata University
  •  COPD治療薬の応用を目指したSCGB3A2ペプチド薬の創製と有効性の検証

    • Principal Investigator
      黒谷 玲子
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48020:Physiology-related
    • Research Institution
      Yamagata University
  •  Optimization of SARS 3CL protease inhibitor and development of anti-COVID-19 drug

    • Principal Investigator
      hattori Yasunao
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38040:Bioorganic chemistry-related
    • Research Institution
      Kyoto Pharmaceutical University
  •  Transglycosylation activity of alpha-1,3-glucanase Agl-KA under semi-dry condition

    • Principal Investigator
      YANO Shigekazu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied microbiology
    • Research Institution
      Yamagata University
  •  Design, synthesis and evaluation of curcumin analogues toward amyloid peptide aggregation inhibition and detectionPrincipal Investigator

    • Principal Investigator
      Konno Hiroyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Yamagata University
  •  Basic research aiming at the application of SCGB3A2 for chronic obstructive pulmonary disease therapeutic drug.

    • Principal Investigator
      Kurotani Reiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Yamagata University
  •  Mechanism of thiamin transport in Helicobacter pylori providing a basis for complementary therapy for the infection.

    • Principal Investigator
      Nosaka Kazuto
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental and hygienic pharmacy
    • Research Institution
      Mukogawa Women's University
  •  Structure activity relationship study of cyclic depsipetide callipeltins with anti-HIV activityPrincipal Investigator

    • Principal Investigator
      Konno Hiroyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Yamagata University
  •  Development of a novel persistent protease inhibitor containing D-amino acid

    • Principal Investigator
      AKAJI Kenichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto Pharmaceutical University
      Kyoto Prefectural University of Medicine
  •  Design and synthesis of the inhibitors for chemokine receptor CCR5Principal Investigator

    • Principal Investigator
      KONNO Hiroyuki
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      Yamagata University
  •  Synthesis and inhibitory activity of cyclic depsi-peptide with anti-HIV activityPrincipal Investigator

    • Principal Investigator
      KONNO Hiroyuki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Signal transduction mechanism underlying thiamin starvation-induced metabolic regulation in Saccharomyces cerevisiae

    • Principal Investigator
      NOSAKA Kazuto
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied biochemistry
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Development of SARS virus inhibitor using unusual amino acid-containing natural products as seeds

    • Principal Investigator
      AKAJI Kenichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  異常アミノ酸含有ペプチド類の全合成と医薬品への展開Principal Investigator

    • Principal Investigator
      今野 博行
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  生物活性を有する異常アミノ酸含有ペプチドの合成とペプチドミミックへの展開Principal Investigator

    • Principal Investigator
      今野 博行
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      The University of Tokushima

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All Journal Article Presentation Book Patent

  • [Book] 遺伝子医学MOOK別冊―次世代ペプチド医薬創製―2014

    • Author(s)
      今野博行
    • Total Pages
      131
    • Publisher
      メディカルドウ
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Book] 遺伝子医学MOOK21号―最新ペプチド合成技術とその創薬研究への応用―2012

    • Author(s)
      今野博行
    • Total Pages
      307
    • Publisher
      メディカルドウ
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Book] 海綿から単離された異常アミノ酸含有ペプチドの合成2012

    • Author(s)
      今野博行
    • Publisher
      遺伝子医学 MOOK21号.最新ペプチド合成技術とその創薬研究への応用.,メディカルドウ(編集)木曽良明
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Book] コンビナトリアル・バイオエンジニアリング(普及版)2010

    • Author(s)
      今野博行
    • Total Pages
      351
    • Publisher
      CMC出版
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Book] コンビナトリアル・バイオエンジニアリング (普及版)2010

    • Author(s)
      今野博行
    • Publisher
      CMC出版(監修)植田充美
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Book] コンビナトリアルバイオエンジニアリングの最前線2004

    • Author(s)
      今野 博行
    • Total Pages
      351
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Structure activity relationship study of NHPI derivatives for ReD-A method and the application for the Fmoc-SPPS.2023

    • Author(s)
      Takamatsu, K.; Suzuki, R.; Matsunaga, A.; Katagiri, H.; Konno, H.
    • Journal Title

      J. Org. Chem.

      Volume: 88 Pages: 1319-1326

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19125
  • [Journal Article] Improved synthesis of 2,4,6-trialkylpyridines from 1,5-diketoalkanes: the total synthesis of Anibamine2019

    • Author(s)
      Miyakoshi Takeru、Konno Hiroyuki
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 17 Issue: 11 Pages: 2896-2905

    • DOI

      10.1039/c8ob02723d

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Design, synthesis and evaluation of curcumin-based fluorescent probes to detect Aβ fibrils2018

    • Author(s)
      Sato Taki、Hotsumi Mayumi、Makabe Koki、Konno Hiroyuki
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 28 Issue: 22 Pages: 3520-3525

    • DOI

      10.1016/j.bmcl.2018.10.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Investigation for the cyclization efficiency of linear tetrapeptides: Synthesis of tentoxin B and dihydrotentoxin2018

    • Author(s)
      Sato Ryota、Oyama Kie、Konno Hiroyuki
    • Journal Title

      Tetrahedron

      Volume: 74 Issue: 42 Pages: 6173-6181

    • DOI

      10.1016/j.tet.2018.09.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Asymmetric synthesis of (2S,3S)-3-Me-glutamine and (R)-allo-threonine derivatives proper for solid-phase peptide coupling2018

    • Author(s)
      Tokairin Yoshinori、Soloshonok Vadim A.、Moriwaki Hiroki、Konno Hiroyuki
    • Journal Title

      Amino Acids

      Volume: 51 Issue: 3 Pages: 419-432

    • DOI

      10.1007/s00726-018-2677-5

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
  • [Journal Article] Deletion of uncharacterized domain from α-1,3-glucanase of <i>Bacillus circulans</i> KA-304 enhances heterologous enzyme production in <i>Escherichia coli</i>2018

    • Author(s)
      Yano Shigekazu、Suyotha Wasana、Zanma Sumika、Konno Hiroyuki、Cherdvorapong Vipavee、Wakayama Mamoru
    • Journal Title

      J. Gen. Appl. Microbiol.

      Volume: 64 Issue: 5 Pages: 212-220

    • DOI

      10.2323/jgam.2017.12.005

    • NAID

      130007503367

    • ISSN
      0022-1260, 1349-8037
    • Language
      English
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Deletion of uncharacterized domain from α-1,3-glucanase of Bacillus circulans KA-304 enhances heterologous enzyme production in Escherichia coli2018

    • Author(s)
      Shigekazu Yano, Wasana Suyoth, Sumika Zanma, Hiroyuki Konno, Vipavee Cherdvorapong, Mamoru Wakayama
    • Journal Title

      The Journal of General and Applied Microbiology

      Volume: 印刷中

    • NAID

      130007503367

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07708
  • [Journal Article] Synthesis of fully protected (2R, 3R, 4S)-4-amino-7-guanidino-3,4-dihydroxy heptanoic acid2017

    • Author(s)
      Yoshino, R.; Tokairin, Y.; Konno H.
    • Journal Title

      Tetrahedron Letters

      Volume: 58 Issue: 16 Pages: 1604-1606

    • DOI

      10.1016/j.tetlet.2017.03.025

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
  • [Journal Article] Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor2017

    • Author(s)
      Konno Hiroyuki、Onuma Takumi、Nitanai Ikumi、Wakabayashi Masaki、Yano Shigekazu、Teruya Kenta、Akaji Kenichi
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 12 Pages: 2746-2751

    • DOI

      10.1016/j.bmcl.2017.04.056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709, KAKENHI-PROJECT-16H05104, KAKENHI-PROJECT-15K01804
  • [Journal Article] Development of reagent for the Fmoc protection to avoid formation of Fmoc-βAla-OH.2017

    • Author(s)
      Yoshino, R.; Kikuchi, M.; Konno, H.
    • Journal Title

      Peptide Science 2016

      Volume: 2017 Pages: 71-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Synthesis of a secretoglobin 3A2 type C (98?139) fragment by Dawson’s native chemical ligation2017

    • Author(s)
      Kikuchi Mariko、Kurotani Reiko、Konno Hiroyuki
    • Journal Title

      Tetrahedron Lett.

      Volume: 58 Issue: 43 Pages: 4145-4148

    • DOI

      10.1016/j.tetlet.2017.09.058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Fmoc-OPhtht, the reagent of Fmoc protection2017

    • Author(s)
      Yoshino, R.; Tokairin, Y.; Kikuchi, M; Konno H.
    • Journal Title

      Tetrahedron Letters

      Volume: 58 Issue: 16 Pages: 1600-1603

    • DOI

      10.1016/j.tetlet.2017.03.021

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
  • [Journal Article] Synthesis of a secretoglobin 3A2 type C (98-139) fragment by Dawson’s native chemical ligation2017

    • Author(s)
      Kikuchi M, Kurotani R, Konno H.
    • Journal Title

      Tetrahedron Letters.

      Volume: 58 Pages: 4145-4148

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09208
  • [Journal Article] Preparation of (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid via enzymatic desymmetrization2017

    • Author(s)
      Tokairin, Y.; Konno, H.
    • Journal Title

      Tetrahedron

      Volume: 73 Issue: 1 Pages: 39-45

    • DOI

      10.1016/j.tet.2016.11.050

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
  • [Journal Article] Design and synthesis of curcumin analogues as probe for Aβ fibrils.2017

    • Author(s)
      Sato, T.; Nikaido, Y.; Yamada, R.; Konno, H.
    • Journal Title

      Peptide Science 2016

      Volume: 2017 Pages: 201-202

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Cytotoxic evaluation of natural and synthetic callipeltins: a revision of cytotoxicity of callipeltin B.2016

    • Author(s)
      Kikuchi, M.; Konno, H.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 80 Issue: 6 Pages: 1066-1069

    • DOI

      10.1080/09168451.2016.1148581

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Synthesis of β-Hydroxytyrosine, A Component of Burkholdines.2016

    • Author(s)
      Konno, H.; Sasaki, Y.; Sato, R.; Zhu, X.-M.; Otsuki, Y.; Ikoma, M.
    • Journal Title

      Nat. Prod. Commun.

      Volume: 11 Pages: 213-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Journal Article] Synthesis of orthogonally protected (2R,3R,4S)-4-amino-2,3-dihydroheptan-1,7-dioic acid.2015

    • Author(s)
      Tokairin, Y.; Maita, K.; Takeda, S.; Konno, H.
    • Journal Title

      Synthesis

      Volume: 47 Issue: 03 Pages: 351-358

    • DOI

      10.1055/s-0034-1378902

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Journal Article] Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors.2015

    • Author(s)
      Konno, H.; Sato, T.; Saito Y.; Sakamoto, I.; Akaji, K.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 22 Pages: 5127-5132

    • DOI

      10.1016/j.bmcl.2015.10.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-16K07709
  • [Journal Article] Structure activity relationship study of burkholdine analogues toward simple antifungal agents.2015

    • Author(s)
      Konno, H.; Abumi, K.; Sasaki, Y.; Yano, S.; Nosaka, K.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 16 Pages: 3199-3202

    • DOI

      10.1016/j.bmcl.2015.05.088

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Journal Article] Synthetic studies on homophymine B: solid phase synthesis of a cyclic fragment.2015

    • Author(s)
      Tokairin, Y.; Takeda, S.; Kikuchi, M.; Konno, H.
    • Journal Title

      Tetrahedron Lett.

      Volume: 56 Issue: 21 Pages: 2809-2812

    • DOI

      10.1016/j.tetlet.2015.04.044

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Journal Article] Synthetic study of peptide aldehydes via acetal/thioacetal transformation: application for Lys/Ser-containing peptides.2015

    • Author(s)
      Konno, H.; Sema, Y.; Tokairin, Y.
    • Journal Title

      Tetrahedron

      Volume: 71 Issue: 21 Pages: 3433-3438

    • DOI

      10.1016/j.tet.2015.03.080

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Journal Article] Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor.2014

    • Author(s)
      Endo, H.; Nikaido, Y.; Nakadate, M.; Ise, S.; Konno, H.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 24 Pages: 5621-5626

    • DOI

      10.1016/j.bmcl.2014.10.076

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Journal Article] Stereochemical assignment of four diastereoisomers of 3,4-dimethylpyroglutamic acid, a moiety of callipeltin B2014

    • Author(s)
      Mari Kikuchi, Hiroyuki Konno
    • Journal Title

      Heterocycles

      Volume: 89 Issue: 7 Pages: 1620-1631

    • DOI

      10.3987/com-14-13003

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J08696, KAKENHI-PROJECT-25450145
  • [Journal Article] Total synthesis of callipeltin B and M, peptidyl marine natural products2014

    • Author(s)
      Mari Kikuchi, Hiroyuki Konno
    • Journal Title

      Organic Letters

      Volume: 16 Issue: 16 Pages: 4324-4327

    • DOI

      10.1021/ol5020619

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J08696, KAKENHI-PROJECT-25450145
  • [Journal Article] Effect of prome-site sequence of retro-inverso-modified HTLV-1 protease inhibitor.2014

    • Author(s)
      Awahara, C.; Tatsumi, T.; Furuta, S.; Shinjoh, G.; Konno, H.; Nosaka, K.; Kobayashi, K.; Hattori, Y.; Akaji, K.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 22 Issue: 8 Pages: 2482-2488

    • DOI

      10.1016/j.bmc.2014.02.050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
  • [Journal Article] Enzymatic and structural characterization of an archaeal thiamin phosphate synthase.2014

    • Author(s)
      Hayashi, M.; Kobayashi, K.; Esaki, H.; Konno, H.; Akaji, K.; Tazuya, K.; Yamada, K.; Nosaka, K.
    • Journal Title

      BBA-Proteins and Proteomics

      Volume: 1844 Issue: 4 Pages: 803-809

    • DOI

      10.1016/j.bbapap.2014.02.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Journal Article] Synthesis and evaluation of inhibitory activity of the curcumin derivatives toward the inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.2014

    • Author(s)
      Konno, H.; Endo, H.; Ise, S.; Miyazaki, K.; Aoki, H.; Sanjo, A.; Hattori, Y.; Akaji, K.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Issue: 2 Pages: 685-690

    • DOI

      10.1016/j.bmcl.2013.11.039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
  • [Journal Article] Solid phase total synthesis and cytotoxicity of callipeltin E and M2013

    • Author(s)
      Kukuchi, M.; Konno, H.
    • Journal Title

      the linear peptides isolated from marine sponge Latrunculia sp

      Volume: in preparation

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Total synthesis of (+)-azimine via diastereoselective aminopalladation2013

    • Author(s)
      Kurogome, Y.; Kogiso, M.; Looi, K. K.; Hattori, Y.; Konno, H.; Hirota, M.; Makabe, H.
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 39 Pages: 8349-8352

    • DOI

      10.1016/j.tet.2013.07.083

    • NAID

      120007106213

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24580160, KAKENHI-PROJECT-25450145
  • [Journal Article] Improved synthesis of D-allothreonine derivatives from L-threonine2013

    • Author(s)
      Mari Kikuchi, Hiroyuki Konno
    • Journal Title

      Tetrahedron

      Volume: 69 Issue: 34 Pages: 7098-7101

    • DOI

      10.1016/j.tet.2013.06.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08696, KAKENHI-PROJECT-25450145
  • [Journal Article] Structure Activity Relationship Study of Callipeltin B for the Cytotoxic Activity2013

    • Author(s)
      Kikuchi , M.; Konno, H.
    • Journal Title

      Peptide Science 2012

      Pages: 145-148

    • NAID

      10031161580

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis and evaluation of Serine Derivatives for SARS 3CL protease2013

    • Author(s)
      Konno, H
    • Journal Title

      Peptide Science 2012

      Volume: なし Pages: 143-144

    • NAID

      10031161579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis and antifungal activities of cyclic octa-lipopeptide burkholdine analogues2013

    • Author(s)
      Konno, H.; Otsuki, Y.; Matsuzaki, K.; Nosaka, K.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 14 Pages: 4244-4247

    • DOI

      10.1016/j.bmcl.2013.04.091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Journal Article] Practical synthesis of peptide C-terminal aldehyde on a solid support2013

    • Author(s)
      Konno, H.; Sema, Y.; Ishii, M.; Hattori, Y.; Nosaka, K.; Akaji, K.
    • Journal Title

      Tetrahedron Lett.

      Volume: 54 Issue: 36 Pages: 4848-4850

    • DOI

      10.1016/j.tetlet.2013.06.103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
  • [Journal Article] Improved synthesis of Fmoc-D-allothreonine derivatives from L-threonine2013

    • Author(s)
      Kikuchi, M.; Konno, H.
    • Volume
      (in press)
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthetic Study of Depsipeptides Analogues of callipeltin B and Its Cytotoxicity2012

    • Author(s)
      Kikuchi, M.; Watanabe, Y; Tanaka, M.; Akaji, K.; Konno, H.
    • Journal Title

      Peptide Science 2011

      Pages: 111-114

    • NAID

      10030204094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthetic study of bioactive natural product as protein inhibitors2012

    • Author(s)
      Konno, H.
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 76(6) Pages: 1-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthetic study of bioactive natural product as protein inhibitors2012

    • Author(s)
      Konno, H.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 76 Pages: 1-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthetic study of callipeltin B analogues and its cytotoxicity2012

    • Author(s)
      Kikuchi, M.; Watanabe, Y.; Tanaka, M.; Akaji, K.; Konno, H.
    • Journal Title

      Proceedings of 32nd European Peptide Symposium

      Pages: 636-637

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Structure-based Design, Synthesis, and Evaluation of Peptide-mimetic SARS 3CL Protease Inhibitors2011

    • Author(s)
      Akaji, K.; Konno, H.; Mitsui, H.; Teruya, K.; Shimamoto, Y.; Hattori, Y.; Ozaki, T.; Kusunoki, M.; Sanjoh, A
    • Journal Title

      J. Med. Chem

      Volume: 54 Pages: 7962-7937

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Synthesis of tokaramide A, a cysteine protease inhibitor from marine sponge Theonella mirabilis2011

    • Author(s)
      Konno, H.; Nosaka, K.; Akaji, K.
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 47 Pages: 9067-9071

    • DOI

      10.1016/j.tet.2011.09.116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis and cytotoxicity of callipeltin B analogues2011

    • Author(s)
      Kikuchi, M.; Watanabe, Y; Tanaka, M.; Akaji, K.; Konno, H.
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 21 Pages: 4865-4868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis of Tokaramide A, a Cysteine Protease Inhibitor from Marine Sponge Theonella aff2011

    • Author(s)
      Konno, H.; Nosaka, K.; Akaji, K
    • Journal Title

      Mirabilis. Tetrahedron

      Volume: 67 Pages: 9067-9071

    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Solid Phase Total Synthesis of Callipeltin E isolated from marine sponge Latrunculia sp.2011

    • Author(s)
      Kikuchi, M.; Nosaka, K ; Akaji, K.; Konno, H.
    • Journal Title

      Tetrahedron Lett.

      Volume: 52 Issue: 30 Pages: 3872-3875

    • DOI

      10.1016/j.tetlet.2011.05.062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors2011

    • Author(s)
      Kenichi. Akaji, et.al.
    • Journal Title

      J.Med.Chem.

      Volume: 54 Issue: 23 Pages: 7962-7973

    • DOI

      10.1021/jm200870n

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017, KAKENHI-PROJECT-21689004, KAKENHI-PROJECT-23550195
  • [Journal Article] Synthesis of N^1- and N^8-(γ-L-Glutamyl) spermidines and (γ-L-Glutamyl) putrescine2011

    • Author(s)
      Toho, K.; Abe, N.; Yamada, T.; the late Ito, Y.; Konno, H.; Kuwahara, S.; Kiyota, H.
    • Journal Title

      Lett.In Org.Chem.

      Volume: 8 Issue: 1 Pages: 1-5

    • DOI

      10.2174/157017811794557813

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthetic Study of Cyclodepsipeptide for Anti-HIV agent2011

    • Author(s)
      Konno, H.; Kikuchi, M.; Maita, K.; Takatsuka, Y.; Nosaka, K.; Akaji, K.
    • Journal Title

      Peptide Science 2010

      Pages: 200-200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis and cytotoxicity of the depsipeptides analogues of callipeltin B2011

    • Author(s)
      Kikuchi M, Watanabe Y, Tanaka M, Akaji K, Konno H
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: vol 21 Issue: 16 Pages: 4865-4868

    • DOI

      10.1016/j.bmcl.2011.06.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21500329, KAKENHI-PROJECT-21689004
  • [Journal Article] Solid Phase Total Synthesis of Callipeltin E isolated from marine sponge Latrunculia sp2011

    • Author(s)
      Kikuchi, M.; Nosaka, K.; Akaji, K.; Konno, H.
    • Journal Title

      Tetrahedron Lett

      Volume: 52(30) Pages: 3872-3875

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxylethyl amine isoster2010

    • Author(s)
      Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
    • Journal Title

      Bioorg Med. Chem

      Volume: 18 Pages: 2720-2727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Evaluation of Retro-Inverso Modifications of HTLV-1 Protease Inhibitors containing a Hydroxyethylamine Isoster2010

    • Author(s)
      Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K.
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 18 Pages: 2720-2727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010

    • Author(s)
      Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
    • Journal Title

      Tetrahedoron

      Volume: 66 Pages: 7946-7953

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Synthetic Studies on Callipeltins: stereoselective syntheses of (3S, 4R)-3,4-dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine2010

    • Author(s)
      Konno, H.; Takebayashi, Y.; Nosaka, K.; Akaji, K.
    • Journal Title

      Heterocycles

      Volume: 81(1) Pages: 79-89

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthetic Studies on Callipeltins : stereoselective syntheses of (3S, 4R)-3,4-dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine2010

    • Author(s)
      Konno, H.; Takebayashi, Y.; Nosaka, K.; Akaji, K.
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 79-89

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010

    • Author(s)
      Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
    • Journal Title

      Tetrahedron

      Volume: 66 Pages: 7946-7953

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-metathesis2010

    • Author(s)
      Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
    • Journal Title

      Tetrahedron

      Volume: 66 Pages: 7946-7953

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis of Annonacin isolated from Annona densicoma2010

    • Author(s)
      Oasa, M.; Hattori, Y.; Konno. H.; Makabe, H.
    • Journal Title

      Biosci.Biocbem.Biotechnol.

      Volume: 74 Pages: 1274-1275

    • NAID

      10027556575

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S, 4R)-3, 4-Dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine from serine derivatives2010

    • Author(s)
      Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 79-89

    • NAID

      40016913697

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S,4R)-3,4-Dimethyl-L-pyroglutamic acid and Fmoc-D- allothreonine from serine derivatives2010

    • Author(s)
      Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 79-89

    • NAID

      40016913697

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster2010

    • Author(s)
      Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
    • Journal Title

      Bioorg.Med.Chem

      Volume: 18 Pages: 2720-2727

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Synthesis of[19.35.36-^<13>C_3]-Labeled TAK779 as a moleculer probe2009

    • Author(s)
      Konno. H., Aimoto, S., Smith, S.O., Nosaka, K., Akaji, K.
    • Journal Title

      Bioorg.Med.Chem. 17

      Pages: 5769-5774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] A Concise Synthesis of Solamin and cis-Solamin, Mono-THF Acetogenins from Annona muricata2009

    • Author(s)
      Makabe, H., Kuwabara, A., Hattori, Y., Konno, H.
    • Journal Title

      Heterocycles 78(9)

      Pages: 2369-2376

    • NAID

      120007106123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis of [19,35,36-13C3]-labeled TAK779 as a Molecular Probe2009

    • Author(s)
      Konno H, Aimoto S, Smith S.O, Nosaka K, Akaji K
    • Journal Title

      Bioorg.Med.Chem 17

      Pages: 5769-5774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Synthesis of [19.35.36-C^^<13>__3]-Labeled TAK779 moleculerprobe2009

    • Author(s)
      Konno, H.; Aimoto, S.; Smith, S. O.; Nosaka, K.; Akaji, K.
    • Journal Title

      Bioorg.Med.Chem

      Volume: 17 Pages: 5769-5774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Synthesis of [19, 35, 36-13C3]-labeled TAK779 as a Molecular Probe.2009

    • Author(s)
      Konno H, ; Aimoto S, ; Smith SO, ; Nosaka K, ; Akaji K
    • Journal Title

      Bioorg Med. Chem

      Volume: 17 Pages: 5769-5774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Journal Article] Evaluation of Lipid-Binding Propahes of the N-Terminal Helical Segment8 in Human Apohpoprotein A-I Using Fragment Peptides2009

    • Author(s)
      Tanaka, M., Tanaka, T., Ohta, S., Kawakami, T., Konno, H., Akaji, K., Aimoto, S., Saito, H.
    • Journal Title

      J.Peptide Sci. 15(1)

      Pages: 36-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Journal Article] Evaluation of Lipid-Binding Propaties of the N-Terminal Helical Segments in Human Apolipoprotein A-I Using Fragment Peptides2008

    • Author(s)
      Tanaka, M.; Tanaka, T.; Ohta, S.; Kawakami, T.; Konno, H.; Akaji, K.; Aimoto, S.; Saito, H
    • Journal Title

      J. Peptide Sci 15(1)

      Pages: 36-42

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Involvement of Thiaminase II Encoded by the THI20 Gene in Thiamin Salvage of Saccharomyces cerevisiae2008

    • Author(s)
      Onozuka, M, et. al.
    • Journal Title

      FEMS Yeast Research 8

      Pages: 266-275

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18580095
  • [Journal Article] Synthesis of Pyranicin and its Inhibitory Action with Bovine Heart Mitochondrial Complex2008

    • Author(s)
      Hattori, N.; Furuhata, S.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T, Makabe, H
    • Journal Title

      I. Org. Lett 10(5)

      Pages: 717-720

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Thiamin-dependent transactivation activity of PDC2 in Saccharomyces2008

    • Author(s)
      Nosaka, K. ; Onozuka, M. ; Konno, H. ; Al
    • Journal Title

      FEBS Lett. 582

      Pages: 3991-3996

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Total synthesis of pyranicin and its deoxygenated analogues and their inhibitory action with bovine heart mitochondrial complex2008

    • Author(s)
      Furuhata, S.; Hattori, Y.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H
    • Journal Title

      I. Tetrahedron 64

      Pages: 7695-7703

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Total synthesis of cis-solamin A, a mono-tetrahydrofuran acetogenin isolated from Annona muricata2008

    • Author(s)
      Konno, H. ; Okuno, Y. ; Makabe, H. ; Nos
    • Journal Title

      Tetrahedron Lett. 49

      Pages: 782-785

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Thiamin-dependent transactivation activity of PDC2 in Saccharomyces2008

    • Author(s)
      Nosaka, K.; Onozuka, M.; Konno, H.; Akaji, K
    • Journal Title

      FEBS Lett 582(29)

      Pages: 3991-3996

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Involvement of Thiaminase II Encoded by the THI20 Gene in Thiamin Salvage of Saccharomyces cerevisiae2008

    • Author(s)
      Onozuka M
    • Journal Title

      FEMS Yeast Research 8

      Pages: 266-275

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18580095
  • [Journal Article] Evaluation of Peptide Aldehyde Inhibitors using R188I Mutant of SARS 3CL Protease as aproteolysis-resistant mutant2008

    • Author(s)
      Akaji, K.; Konno, H.; Onozuka, M.; Makino, A.; Nosaka, K
    • Journal Title

      Bioorg. Med. Chem 16

      Pages: 9400-9408

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Total synthesis of cis-solamin A, a mono-tetrahydrofuran acetogenin isolated from Annona muricata2008

    • Author(s)
      Konno, H.; Okuno, Y.; Makabe, H.; Nosaka, K.; Onishi, A.; Abe, N.; Sugimoto, A.; Akaji, K
    • Journal Title

      Tetrahedron Lett 49(5)

      Pages: 782-785

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Possible involvement of thiaminase II encoded bythe THI20 gene in thiamine salvage ofSaccharomyces cerevisiae2008

    • Author(s)
      Onozuka, M.; Konno, H.; Kawasaki, Y.; Akaji, K.; Nosaka, K
    • Journal Title

      J. FEMS Yeast Research 8(2)

      Pages: 266-275

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Evaluation of Peptide Aldehyde Inhibitors using R1881 Mutant of SARS 3CL Protease as a proteolysi2008

    • Author(s)
      Akaji, K. ; Konno, H. ; Onozuka, M. ; Mak
    • Journal Title

      Bioorg. Med. Chem. 16

      Pages: 9400-9408

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Studies on Substrate Specificity at PR/p3 Cleavage Site of HTVL-1 Protease2007

    • Author(s)
      Bang, J. K.; Teruya, K.; Aimoto, S.; Konno, H.; Nosaka, K.; Tatsumi, T.; Akaji, K.
    • Journal Title

      Int. J. Peptide Res. 13

      Pages: 173-179

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Synthesis of (17S, 18S)-and (17R, 18R)-tonkinelin and their inhibitory action with bovine heart mitochondorial complex2007

    • Author(s)
      Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.
    • Journal Title

      I. Bioorg. Med. Chem 15

      Pages: 3026-3031

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Synthesis,determination of the absolute configuration of tonkinelin and inhibitory action with bovine heart mitochondrial complex I2007

    • Author(s)
      Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T; Makabe, H.
    • Journal Title

      Bioorg.Med.Chem 15

      Pages: 3026-3031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Total Synthesis of Miraziridine A and Identification of Its Major Reaction Site for Cathepsin B2007

    • Author(s)
      Konno H
    • Journal Title

      Tetrahedron 63

      Pages: 9502-9513

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590010
  • [Journal Article] Synthesis of All Stereoisomers of β-Methoxy Tyrosine Derivatives and Identification of the Absolute Configration in Callipeltin2007

    • Author(s)
      Konno, H.; Aoyama, S.; Nosaka, K.; Akaji, K
    • Journal Title

      E, Synthesis (23)

      Pages: 3666-3672

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Total Synthesis of Miraziridine A and Identification of Its Major Reaction Site for Cathepsin B2007

    • Author(s)
      Konno, H
    • Journal Title

      Tetrahedron 63

      Pages: 9502-9513

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590010
  • [Journal Article] Stereoselective Synthesis of All Stereoisomers of β-Methoxy Tyrosine Derivatives for Identification of the Absolute Configuration in Callipeltin E2007

    • Author(s)
      Konno, H.; Aoyama, S.; Nosaka, K; Akaji, K
    • Journal Title

      Synthesis 23

      Pages: 3666-3672

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Total synthesis of miraziridine A and identification of major reaction site for cathepsin B2007

    • Author(s)
      Konno, H.; Kubo, K.; Makabe, H.; Toshiro, E.; Hinoda, N.; Nosaka, K.; Akaji, K
    • Journal Title

      Tetrahedron 63(38)

      Pages: 9502-9513

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Synthesis of Miraziridine A and Identification of Its Major Reactive Site for Cathepsin2007

    • Author(s)
      Konno, H.; Kubo, K.; Makabe, H.; Toshiro, E.; Nosaka, K.; Akaji, K. Total
    • Journal Title

      B. Tetrahedron 63(38)

      Pages: 9502-9513

    • Data Source
      KAKENHI-PROJECT-19790095
  • [Journal Article] Synthesis of (4R, 15R, 16R, 21S)-and (4R, 15R, 16R, 21S)-rollicosin and squamostolide, and their inhibitory action with bovine heart mitochondeial complex I.2006

    • Author(s)
      Makabe, H., Kimura, Y., Higuchi, M., Konno, H., Murai, M., Miyoshi, H.
    • Journal Title

      Bioorganic and Medicinal Chemistry 14・9

      Pages: 3119-3130

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Synthesis of Murisolin, (15R, 16R, 19R, 20S)-Murisolin-A, (15R, 16R, 19R, 20S)-16, 19-cis-Murisokin-A, and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I.2006

    • Author(s)
      Hattori, Y., Kimura, Y., Moroda, A., Konno, H., Abe, M., Miyoshi, H., Goto, T., Makabe, H.
    • Journal Title

      Chemistry-Asian Journal 1・6

      Pages: 894-904

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Evaluations of Substrate Specificity and Inhibition at PR/p3 Cleavage Site of HTLV-1 Protease.2006

    • Author(s)
      Naka, H., Teruya, K., Bang, J.K., Aimoto, S., Tatsumi, T., Konno, H., Nosaka, K., Akiji, K.
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters 16・14

      Pages: 3761-3764

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Synthetic Studies of Tokaramide A and Miraziridine A Isolated from Marine Sponge Theonella aff. mirabilis.2006

    • Author(s)
      Konno, H., Kubo, K., Makabe, H., Fujii, N., Nosaka, K., Akaji, K.
    • Journal Title

      Peptide Sciences

      Pages: 47-50

    • NAID

      10017675327

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] First Synthesis of Trans- and Cis-Dendrochrysanines.2006

    • Author(s)
      Konno H.
    • Journal Title

      Heterocycles 68・12

      Pages: 2579-85

    • NAID

      40015181995

    • Data Source
      KAKENHI-PROJECT-18580095
  • [Journal Article] First syntheses of Trans-and Cis-dendrochrysanines.2006

    • Author(s)
      Konno, H., Kusumoto, S., Kanai, S., Yamahana, Y., Nosaka, K., Akaji, K.
    • Journal Title

      Heterocycles 68・12

      Pages: 2579-2585

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] First synthesis of trans- and cis-dendrochrysanines2006

    • Author(s)
      Hiroyuki Konno
    • Journal Title

      Heterocycles 68

      Pages: 2579-2585

    • NAID

      40015181995

    • Data Source
      KAKENHI-PROJECT-18590010
  • [Journal Article] Synthetic studies on miraziridine A, a cysteine protease inhibitor isolated from Theonella aff. mirabilis2006

    • Author(s)
      Hiroyuki Konno
    • Journal Title

      Peptide Science 2006

      Pages: 37-38

    • NAID

      10020528846

    • Data Source
      KAKENHI-PROJECT-18590010
  • [Journal Article] Molecular Cloning and Analysis of the 5'-Flanking Region of the Human Thiamin Pyrophosphokinase gene.2005

    • Author(s)
      Onozuka, M., Konno, H., Akaji, K., Nishino, H., Nosaka, K.;
    • Journal Title

      J.Nutr.Sci.Vitaminol. 51・4

      Pages: 274-277

    • NAID

      110002704076

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae2005

    • Author(s)
      Nosaka K., Onozuka, M., Konno, H., Kawasaki, Y., Nishino H., Sano, M., Akaji, K.;
    • Journal Title

      Mol.Microbiol. 58・2

      Pages: 467-479

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Synthesis of (4R,15R,16R,21S)-and (4R,15S,16S,21S)-rollicosin.2005

    • Author(s)
      Makabe H., Higuchi, M., Konno, H., Murai, M., Miyoshi, H.;
    • Journal Title

      Tetrahedron Lett. 46

      Pages: 4671-4675

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Solid-Phase Synthesis of Olefin-containing Inhibitors for HTLV-1 Protease using the Horner-Emmons Reaction.2005

    • Author(s)
      Bang, J.K., Naka, H., Teruya, K., Aimoto, S., Konno, H., Nosaka, K., Akaji, K.;
    • Journal Title

      J.Org.Chem. 70・25

      Pages: 10596-10599

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Molecular Cloning and Analysis of the 5'-Flanking Region of the Human Thiamin Pyrophosphokinase gene2005

    • Author(s)
      Onozuka, M., Konno, H., Akaji, K., Nishino, H., Nosaka, K.
    • Journal Title

      J. Nutr. Sci, Vitaminol (印刷中)

    • NAID

      110002704076

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Synthesis of cis-Solamin and Its Inhibitory Action with Mitochondrial Complex I2004

    • Author(s)
      Makabe, H., Hattori, Y., Kimura, Y., Konno, H., Abe, M., Miyoshi, H., Tanaka, A.
    • Journal Title

      Tetrahedron 60

      Pages: 10651-10657

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Journal Article] Synthesis and Mitochondrial Inhibition of Dihydroxy-Cohibin A, Non-THF Annonaceous Acetogenin Analogue2004

    • Author(s)
      Konno, H., Hiura, N., Manabe, H., Abe, M., Miyoshi, H.
    • Journal Title

      Bioorg. Med. Chem. Lett. 13

      Pages: 629-632

    • Data Source
      KAKENHI-PROJECT-16790084
  • [Patent] クルクミン誘導体2017

    • Inventor(s)
      今野博行
    • Industrial Property Rights Holder
      今野博行
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-23
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Synthesis and evaluation of phthalimide type inhibitors against SARS-CoV 3CL protease2024

    • Author(s)
      佐野陽菜, 遠藤龍生, 照屋健太, 服部恭尚, 矢野成和, 今野博行
    • Organizer
      日本農芸化学会2024年会
    • Data Source
      KAKENHI-PROJECT-22K19125
  • [Presentation] SARS-CoV 3CL proteaseを標的としたフタルイミド型阻害剤の合成研究2024

    • Author(s)
      佐野陽菜、遠藤龍生、照屋健太、服部恭尚、矢野成和、今野博行
    • Organizer
      日本農芸化学会2024年度大会
    • Data Source
      KAKENHI-PROJECT-21K05417
  • [Presentation] Synthesis ans structural elucidaton of antatollamide A and its derivatives2024

    • Author(s)
      Yitong Li,Keigo Takahmatsu, Hiroyuki Konno
    • Organizer
      日本農芸化学会2024年会
    • Data Source
      KAKENHI-PROJECT-22K19125
  • [Presentation] Design, Synthesis and Evaluation of NHPI-based SARS-CoV 3CL Protease Inhibitors2023

    • Author(s)
      Ryusei Endo, Hinata Sano, Koki Makabe, Shigekazu Yano, Yasunao Hattori, Kenta Teruya and Hiroyuki Konno
    • Organizer
      The 60th Japanese Peptide Symposium Schedule
    • Data Source
      KAKENHI-PROJECT-21K05417
  • [Presentation] フタルイミド型SARS-CoV 3CL protease阻害剤の構造活性相関研究2023

    • Author(s)
      佐野陽菜、及川慧人、遠藤龍生、照屋健太、服部恭尚、赤路健一、矢野成和、今野博行
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PROJECT-21K05417
  • [Presentation] Reversible detection method of amino groups during Fmoc-solid phase peptide synthesis2023

    • Author(s)
      Hioyuki Konno
    • Organizer
      Asai-Pacific international symposium on microscale separations and analysis 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19125
  • [Presentation] 細菌型α-1,3-グルカナーゼを用いたニゲロオリゴ糖生産2019

    • Author(s)
      矢野成和,玉木友理,小黒夏樹,今野博行, 若山 守
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-17K07708
  • [Presentation] システイン検出試薬及びジスルフィド架橋剤としてのポリオキソメタレートの応用研究2018

    • Author(s)
      休石悠人, 矢野成和, 今野博行
    • Organizer
      第8回化学フェスタ
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Synthesis of fluorescent antagonists as molecular probes for CCR5 binding assays2018

    • Author(s)
      齋藤拓也, 山口諒平, 東海林由憲, 横山智哉子, 今野博行
    • Organizer
      化学系学協会東北大会
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] ON/OFF機構により蛍光を制御するAβ凝集体検出のための新規クルクミン型蛍光プローブの探索2018

    • Author(s)
      穂積 真由美, 佐藤 多記, 田尻 美理, 今野 博行
    • Organizer
      第26回山形分子生物学セミナー
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] 新規アルツハイマー病治療薬の開発を目指したBerberineの合成研究2018

    • Author(s)
      山田亮, 今野博行
    • Organizer
      日本農芸化学会東北北海道合同支部会
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] 含窒素複素環式天然物Anibamineの合成を指向した新規ピリジン合成法の開発2018

    • Author(s)
      宮腰建, 今野博行
    • Organizer
      第35回有機合成化学セミナー
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] 新しいFmoc化剤Fmoc-OPhthの開発2017

    • Author(s)
      今野博行, 吉野諒, 東海林由憲
    • Organizer
      日本農芸化学会東北支部会
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Aβ凝集体特異的に結合し機能を発揮するクルクミン誘導体の開発2017

    • Author(s)
      佐藤多記, 二階堂由莉, 穂積真由美, 照屋健太, 今野博行
    • Organizer
      認知症を知る若手研究者の集まり
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Synthetic study of cyclic depsi-peptide isolated from marine sponge2017

    • Author(s)
      Hiroyuki Konno
    • Organizer
      Invited Lecture of Joint Symposium of Tohoku University & Dalian University
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Total synthesis of callipeltin B, Peptydyl Marine Natural Product2017

    • Author(s)
      Hiroyuki Konno
    • Organizer
      Invited Lecture of Dalian University
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Synthesis of Secretoglobin 3A2 fragments using Dawson resin by Native.2017

    • Author(s)
      菊池真梨子, 黒谷玲子, 今野博行
    • Organizer
      日本化学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-15K09208
  • [Presentation] Development of curcumin analogues: detection of Aβ fibrils and its aggregation inhibition2017

    • Author(s)
      佐藤多記, 穂積真由美, 今野博行
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] アミロイドβ凝集体に特異的に結合するクルクミン様物質の開発2017

    • Author(s)
      今野博行, 二階堂由莉, 佐藤多記
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2017-03-18
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Aβ凝集体検出色素クルクミンアナログの開発2016

    • Author(s)
      佐藤多記, 二階堂由莉, 山田亮, 今野博行
    • Organizer
      第48回若手ペプチド夏の勉強会
    • Place of Presentation
      八王子市大学セミナーハウス
    • Year and Date
      2016-07-31
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Amyloid β に特異的に結合し構造制御するクルクミン様物質の開発2016

    • Author(s)
      二階堂由莉, 佐藤多記, 今野博行
    • Organizer
      第27回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Aβ凝集体特異的に結合し蛍光を発するクルクミン誘導体の開発2016

    • Author(s)
      佐藤多記, 二階堂由莉, 山田亮, 今野博行
    • Organizer
      認知症を知る若手研究者の集まり
    • Place of Presentation
      ニューサンピア高崎
    • Year and Date
      2016-07-30
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] アミロイドβ凝集体に特異的に結合するクルクミン様物質の開発2016

    • Author(s)
      今野博行, 二階堂由莉, 佐藤多記
    • Organizer
      第24回山形分子生物学セミナー
    • Place of Presentation
      山形大学農学部
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] ミロイド β 凝集体を検出するクルクミン型蛍光プローブの開発2016

    • Author(s)
      佐藤多記, 二階堂由莉, 今野博行
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Amyloid β に特異的に結合し構造制御するクルクミン様物質の開発2016

    • Author(s)
      今野博行
    • Organizer
      日本食品科学工学会年会
    • Place of Presentation
      名城大学
    • Year and Date
      2016-08-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07709
  • [Presentation] Callipeltin B, EおよびMの全合成と細胞毒性評価2015

    • Author(s)
      菊池真理, 今野博行
    • Organizer
      第26回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] Total synthesis of callipeltin B2015

    • Author(s)
      Konno, H.; Kikuchi, M.
    • Organizer
      7th International Peptide Symposium
    • Place of Presentation
      Biopolis, Singapore(シンガポール)
    • Year and Date
      2015-12-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] 環状デプシペプチドcallipeltin Bの全合成と細胞毒性評価2015

    • Author(s)
      今野博行, 菊池真理
    • Organizer
      日本農芸化学会東北支部会
    • Place of Presentation
      東北大学農学部
    • Year and Date
      2015-10-03
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] Callipeltin Bの全合成2015

    • Author(s)
      今野博行
    • Organizer
      第47回若手ペプチド夏の勉強会
    • Place of Presentation
      アスティかたおか
    • Year and Date
      2015-08-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] 抗HIV活性を有する環状ペプチド homophymine B の合成研究:異常アミノ酸の合成と環状部の構築2015

    • Author(s)
      吉野諒, 東海林由, 菊池真理, 武田祥, 今野博行
    • Organizer
      第47回若手ペプチド夏の勉強会
    • Place of Presentation
      アスティかたおか
    • Year and Date
      2015-08-09
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] Callipeltin Bの合成研究:環化部位の探索2014

    • Author(s)
      菊池真理, 今野博行
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学、川崎市
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] Homophymine Aの全合成を目指した立体選択的異常アミノ酸の合成と環状部構築のアプローチ2014

    • Author(s)
      東海林由憲, 武田祥, 菊池真理, 今野博行
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      明治大学、川崎市
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] 異常アミノ酸含有環状ペプチド誘導体の合成と構造活性相関2014

    • Author(s)
      今野博行
    • Organizer
      日本農芸化学会中部支部創立60周年記念若手シンポジウム
    • Place of Presentation
      信州大学農学部(長野県南箕輪村)
    • Year and Date
      2014-11-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] 抗 HIV活性を有する phomophymine Aの合成研究:異常アミノ酸部の合成2013

    • Author(s)
      ○武田祥 ,菊池真理 ,米田翔 ,今野博行
    • Organizer
      日本農芸化学会 2013年度大会
    • Place of Presentation
      東北大学川内キャンパス(宮城県)
    • Year and Date
      2013-03-25
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Synthetic study on homophymine A: stereoselective synthesis of unusual amino acids2013

    • Author(s)
      ○Takeda, S.; Maita, K.; Tokairin, Y.; Konno, H.
    • Organizer
      UK/Japan Conference in Catalytic Asymmetric Synthesis
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2013-04-19
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Callipeltin Bの全合成研究2013

    • Author(s)
      今野博行, 菊池真理, 菊地唯, 朱秀梅, 赤路健一
    • Organizer
      第52回天然有機化合物討論会
    • Place of Presentation
      同志社大学、京都市
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] 異常アミノ酸含有ペプチドのデザインと疾患関連蛋白質阻害剤の創製2013

    • Author(s)
      ○今野博行
    • Organizer
      日本農芸化学会フロンティアシンポジウム
    • Place of Presentation
      秋湯クレセントホテル(宮城県)
    • Year and Date
      2013-03-28
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 異常アミノ酸含有直鎖ペプチド callipeltin Mの固相全合成2013

    • Author(s)
      ○菊池真理 ,今野博行
    • Organizer
      日本農芸化学会 2013年度大会
    • Place of Presentation
      東北大学川内キャンパス(宮城県)
    • Year and Date
      2013-03-25
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Synthetic study on homophymine A: stereoselective synthesis of unusual amino acids. UK/Japan Conference in Catalytic Asymmetric Synthesis2013

    • Author(s)
      Takeda, S.; Maita, K.; Tokairin, Y.; Konno, H.
    • Organizer
      UK/Japan Conference in Catalytic Asymmetric Synthesis
    • Place of Presentation
      仙台国際センター、仙台市
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] カリペルチンBの合成研究:ジメチルピログルタミン酸4種のジアステレオマーの合成とその立体化学について2013

    • Author(s)
      菊池真理、今野博行
    • Organizer
      日本農芸化学会東北支部会
    • Place of Presentation
      岩手大学、盛岡市
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] Structure activity relationship study of callipeltin B for the cytotoxic activity2012

    • Author(s)
      ○菊池真理 ,今野博行
    • Organizer
      第49回ペプチド討論
    • Place of Presentation
      鹿児島県民会館(鹿児島県)
    • Year and Date
      2012-01-17
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] callipeltin Bの全合成研究2012

    • Author(s)
      ○菊池真理 ,今野博行
    • Organizer
      第28回若手研究者の仙台セミナー
    • Place of Presentation
      東北大学薬学部(宮城県)
    • Year and Date
      2012-12-01
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Callipeltin Eの固相全合成2012

    • Author(s)
      ○菊池真理 ,野坂和人 ,赤路健一 ,今野博行
    • Organizer
      日本農芸化学会 2012年度大会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2012-03-23
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Synthetic study of callipeltin B analogues and its cytotoxicity2012

    • Author(s)
      Kikuchi, M.; Watanabe, Y.; Tanaka, M.; Akaji, K.; Konno, H.
    • Organizer
      32nd European Peptide Symposium
    • Place of Presentation
      September 4, 2012, Megaron Athens International Conference Centre (Athens, Greece) J. Pep. Sci
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 抗 HIV活性を有する環状デプシペプチド類の全合成研究2012

    • Author(s)
      ○米田翔 ,菊池真理 ,武田祥 ,今野博行
    • Organizer
      日本農芸化学会東北支部会
    • Place of Presentation
      弘前大学農学生命科学部(青森県)
    • Year and Date
      2012-10-06
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 天然物を範とする疾患関連蛋白質阻害剤の創成研究2011

    • Author(s)
      ○今野博行
    • Organizer
      日本農芸化学会東北支部
    • Place of Presentation
      山形大学農学部(山形県)
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Callipeltin Bの全合成研究:モデルペプチドの環化反応2011

    • Author(s)
      ○菊池真理 ,米田翔 ,赤路健一 ,今野博行
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2011-03-26
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 疾患に関わるシステインプロテアーゼの阻害剤創成研究2011

    • Author(s)
      今野博行
    • Organizer
      東北大学大学院薬学研究科学術講演会
    • Place of Presentation
      東北大学薬学部(招待講演)
    • Year and Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Synthetic study of the depsipeptides analogues of callipeltin B and its cytotoxicy2011

    • Author(s)
      ○菊池真理 ,渡辺善久 ,田中雅樹 ,赤路健一 ,今野博行
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-09-28
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Synthetic Study of Callipeltin A, An Anti-HIV cyclodepsipeptide isolated from Marine Sponge2010

    • Author(s)
      ○Konno, H.; Kikuchi, M.; Maita, K.; Nosaka, K.; Akaji, K.
    • Organizer
      Int. Peptide Symposium (IPS5)
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 抗 HIV活性を有する環状デプシペプチドの全合成研究2010

    • Author(s)
      今野博行 ,○菊池真理 ,米田翔 ,高塚由美子 ,野坂和人 ,赤路健一
    • Organizer
      第43回若手ペプチド夏の勉強会
    • Place of Presentation
      ウェルネスパーク五色(兵庫県)
    • Year and Date
      2010-08-05
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Callipeltin Bの全合成研究 : pyrodiMeGln-D-alloThr(N-MeAla)-OHの合成2010

    • Author(s)
      ○今野博行 ,○菊地真理 ,野坂和人 ,赤路健一
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東京大学駒場キャンパス(東京都)
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] CCR5阻害剤 TAK779の C^^<13>ラベル体合成2010

    • Author(s)
      今野博行 ,○高沼大樹 ,千葉裕己 ,相本三郎 , Steven O. Smith,赤路健一
    • Organizer
      日本農芸化学会東北北海道合同支部
    • Place of Presentation
      東北大学農学部(宮城県)
    • Year and Date
      2010-09-28
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 抗 HIV活性を有する環状デプシペプチド類の全合成研究 : β -MeOTyr, β-MeOThrおよびアミノヘプタノール誘導体の合成研究2010

    • Author(s)
      今野博行 ,○米田翔 ,菊池真理 ,野坂和人,赤路健一
    • Organizer
      日本農芸化学会東北北海道合同支部会
    • Place of Presentation
      東北大学農学部(宮城県)
    • Year and Date
      2010-09-27
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] SARS 3CLプロテアーゼ阻害剤創成を目指したペプチドアルデヒドの合成と阻害能評価2010

    • Author(s)
      今野博行、石井学、服部恭尚、野坂和人、赤路健一
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Presentation] Konno, H. ; Kikuchi, M. ; Maita, K. ; Nosaka, K. ; Akaji, K. ; Synthetic Study of Callipeltin A, An Anti-HIV cyclodepsipeptide isolated from Marine Sponge2010

    • Author(s)
      Konno, H.; Kikuchi, M.; Maita, K.; Nosaka, K.; Akaji, K.
    • Organizer
      Int.Peptide Symposium (IPS5)
    • Place of Presentation
      京都国際会館
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 疾患関連蛋白質を標的とした阻害剤の創成研究2010

    • Author(s)
      ○今野博行
    • Organizer
      第14回山形大学大学院理工学研究科セミナー
    • Place of Presentation
      山形大学工学部(山形県)
    • Year and Date
      2010-08-31
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Synthesis and Evaluation of Small PeptideInhibitors for SARS 3CL Protease2010

    • Author(s)
      Hiroyuki Konno, Manabu Ishii, Yasunao Hattori, Kazuto Nosaka, Kenichi Akaji
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Presentation] 疾患に関わるシステインプロテアーゼの阻害剤創成研究2010

    • Author(s)
      今野博行
    • Organizer
      第43回若手ペプチド夏の勉強会
    • Place of Presentation
      兵庫県淡路島ウェルネスパーク五色
    • Year and Date
      2010-08-02
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 構造解析に基づくSARS 3CL Protease阻害剤の設計とその阻害能評価2010

    • Author(s)
      今野博行、石井学、野坂和人、服部恭尚、赤路健一
    • Organizer
      東北支部第145回大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Presentation] 異常アミノ酸含有天然物の合成と機能性分子創成への展開2009

    • Author(s)
      今野博行
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] Design of small molecular inhibitor for SARS 3CL protease besed on structure analysis2009

    • Author(s)
      Akaji K, Nosaka K, Hattori Y, Mitsui H, Konno H, Kusunoki M, Ozaki T, Sanjo A
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Presentation] SARS 3CLプロテアーゼ阻害に必要なチオール反応性官能基の評価2009

    • Author(s)
      三井寛法、高橋麻矢子、今野博行、野坂和人、赤路健一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Presentation] 環状デプシペプチド callipeltin Bの固相全合成研究2009

    • Author(s)
      今野博行 ,野坂和人 ,赤路健一
    • Organizer
      日本薬学会年会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 異常アミノ酸含有天然物の合成と機能性分子創成への展開2009

    • Author(s)
      ○今野博行
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州市国際会議場(福岡県)
    • Year and Date
      2009-11-06
    • Data Source
      KAKENHI-PROJECT-21689004
  • [Presentation] 固相法によるペプチドアルデヒド類の実践的合成法の検討2009

    • Author(s)
      今野博行、石井学、服部恭尚、野坂和人、赤路健一
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Presentation] 構造解析に基づくペプチドアルデヒド型SARS 3CLプロテアーゼ阻害剤の合成と評価2009

    • Author(s)
      今野博行、野坂和人、小野塚真理、三井寛典、赤路健一、楠木正巳、尾崎健、三城明
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-16
    • Data Source
      KAKENHI-PROJECT-21590017
  • [Presentation] Synthestic Studies on Callipeltins B and E isolated form marine sponge2008

    • Author(s)
      今野博行、野坂和人、赤路健一
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京、船堀タワーホール
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] 変異型SARS3CLproteaseを用いた新規アルデヒド型阻害剤の評価2008

    • Author(s)
      高橋麻矢子、野坂和人、今野博行、赤路健一
    • Organizer
      日本薬学会年会、2008年度大会要旨集2
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2008-03-29
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] Synthestic Studies on Callipeltins B and E isolated form marine sponge2008

    • Author(s)
      今野博行、野坂和人、赤路健一
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京都、船堀タワーホール
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] レトロインベルソペプチド型HTLV-1プロテアーゼ阻害剤の合成と構造活性相関2008

    • Author(s)
      粟原千如、辰巳正、今野博行、野坂和人、赤路健一
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都市、京都テルサ
    • Year and Date
      2008-11-04
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] Syntheses and Evaluations of Peptide based Inhibitors for R188I Mutant of SARS 3CL protease2008

    • Author(s)
      三井寛法、高橋真矢子、今野博行、野坂和人、赤路健一
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京都、船堀タワーホール
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] ミトコンドリアComplexIを阻害するアセトゲニンcis-solamin-Aの合成と阻害能に関する研究2008

    • Author(s)
      今野博行、奥野康弘、真壁秀文、野坂和人、赤路健一
    • Organizer
      日本薬学会年会、2008年度大会要旨集2
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2008-03-28
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] レトロインベルソペプチド型HTLV-1プロテアーゼ阻害剤の合成2008

    • Author(s)
      粟原千如、辰巳正、今野博行、野坂和人、赤路健一
    • Organizer
      日本薬学会年会、2008年度大会要旨集2
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2008-03-29
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] Evaluation of peptide-based inhibitors using R188I mutant of SARS 3CL protease as aproteolysis-resistant mutant2007

    • Author(s)
      赤路健一、今野博行、小野塚真理、齋藤裕行、牧野歩、野坂和人
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      富山市、富山コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] レトロインベルソペプチド型HTLV-1プロテアーゼ阻害剤の合成と構造活性相関2007

    • Author(s)
      辰巳正、粟原千如、仲裕美、相本三郎、今野博行、野坂和人、赤路健一
    • Organizer
      メディシナルケミストリーシンポジウム
    • Place of Presentation
      相模原市、相模原文化センター
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] Total Synthesis of Miraziridine A and Its Analogues.2007

    • Author(s)
      Konno, H.; Kubo, K; Makabe, H.; Nosaka, K; Akaji, K.
    • Organizer
      Int. Peptides Sympodium(IPS4)
    • Place of Presentation
      Cairns,Australia
    • Year and Date
      2007-10-23
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] Synthesis and structure activity relationship Studies of iraziridine A, a cysteine protease inhibitor2007

    • Author(s)
      今野博行、久保佳奈子、真壁秀文、野坂和人、赤路健一
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      富山市、富山コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] ブリックホール2006

    • Author(s)
      今野博行、久保佳奈子、真壁秀文、野坂和人、赤路健一
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎市
    • Data Source
      KAKENHI-PROJECT-19790095
  • [Presentation] 常アミノ酸含有ペプチド callipeltin 類の合成研究: 副産物の解析

    • Author(s)
      菊池真理, 今野博行
    • Organizer
      日本農芸化学会北海道東北合同支部会
    • Place of Presentation
      北海道大学農学部(札幌市)
    • Year and Date
      2014-09-22 – 2014-09-23
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] 海綿由来環状デプシペプチドHomophymine の全合成を目指した異常アミノ酸の立体制御合成

    • Author(s)
      吉野諒, 東海林由憲,武田祥,今野博行
    • Organizer
      化学系学協会東北大会
    • Place of Presentation
      山形大学工学部(米沢市)
    • Year and Date
      2014-09-20 – 2014-09-21
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] アルツハイマー病関連蛋白質を標的とした阻害剤創製研究

    • Author(s)
      今野博行
    • Organizer
      化学系学協会東北大会有機化学コロキウム
    • Place of Presentation
      山形大学工学部(米沢市)
    • Year and Date
      2014-09-20 – 2014-09-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-25450145
  • [Presentation] Solid phase synthesis of the cyclic fragment of homophymine B

    • Author(s)
      東海林由憲, 吉野諒, 武田祥, 今野博行
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島大学薬学部(徳島市)
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-25450145
  • 1.  NOSAKA Kazuto (10228314)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 16 results
  • 2.  Kurotani Reiko (00453043)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  阿部 宏之 (10375199)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  AKAJI Kenichi (60142296)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 5.  柴田 陽光 (60333978)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  KUMAKI Nobue (90366021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YANO Shigekazu (50411228)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  hattori Yasunao (20567028)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  ONO Sotaro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KINOSHITA Takamune
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  WATANABE Yoshihisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  真壁 秀文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  廣田 満
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  田中 雅樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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