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Nogami Keiji  野上 恵嗣

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NOGAMI Keiji  野上 恵嗣

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Researcher Number 50326328
Affiliation (Current) 2025: 奈良県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2020 – 2024: 奈良県立医科大学, 医学部, 教授
2011 – 2020: 奈良県立医科大学, 医学部, 准教授
2009 – 2010: Nara Medical University, 医学部, 講師
2007 – 2008: Nara Medical University, School of Medicine, Assistant lecturer
2007: 奈良県立医科大学, 医科部, 助教
2005 – 2006: Nara Medical Univ., Facult. Med., Assistant, 医学部, 助手
Review Section/Research Field
Principal Investigator
Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Except Principal Investigator
Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 55060:Emergency medicine-related / Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords
Principal Investigator
第VIII因子 / 活性型第VII因子 / 血液凝固 / トロンビン / 結合部位 / 活性化 / 凝固 / 第IX因子 / 組織因子 / 活性化/不活化 … More / 外因系 / 機能構造 / 血友病 / 遺伝子組み換え蛋白 / 機能獲得型蛋白 / 遺伝子組み換え / 結合領域 / FVIII / インヒビター / 炎症性因子 / プロテインS / プラスミン / 不活化 / 相互作用 / 酵素 / 凝固抑制系 / 線溶系 / 包括的凝固機能 / 血友病マウス / 結合 / 機能 / 凝固機能 / 遺伝子組換え蛋白 / ノックアウトマウス / 遺伝子組み換え型 / 凝固因子 / 機能獲得型 / 結合様式 / 高機能獲得型蛋白 / 活性型第IX因子 / 活性化第IX因子 / 機能獲得 / 第VII因子 / 活性化第VII因子 / 内因系 / FVIIa / 第X因子 / 凝固機序 / 出血性疾患 / 蛋白相互作用 / 第Ⅷ因子 / 長時間作用型 / 内因系因子 … More
Except Principal Investigator
血友病A / 第VIII因子 / 血友病 / インヒビター / 血液凝固 / 凝固線溶波形解析 / 蛋白質 / 血栓止血 / 凝固 / 第X因子 / 第IX因子 / プロテインS / 活性型プロテインC / 活性化プロテインC / 凝固因子 / 間葉系幹細胞 / 脾臓 / 線溶 / F8遺伝子変異 / 遺伝子 / 一塩基多型 / 血液凝固第VIII因子 / フォン・ウィルブランド病 / フォン・ウィルブランド因子 / 出血症状 / 凝固波形解析 / 内科 / FVIII / 血液 / トロンビン / 凝固機能 / 凝固波形 / 血管内皮細胞 / 血流 / 抗凝固 / 凝固機能評価 / 後天性凝固異常症 / 凝固第VIII因子 / 血栓症 / 中和抗体 / 凝固異常 / 一塩基バリアント解析 / クリアランス受容体 / 迅速診断法 / 波形解析 / 凝固線溶機能評価 / 保因者 / プラズマ細胞 / 抗FVIII免疫応答 / ヒト化血友病マウス / 脾臓微小環境 / 高力価インヒビター / 補充療法 / ニッチ / 抗FVIII中和抗体 / 微小環境 / 血栓性微小血管障害症 / 肝類洞閉塞症候群 / トロンビンプラスミン生成試験 / トロンビン・プラスミン生成試験 / 播種性血管内凝固 / 小児がん / 分子異常症 / 小児科 / リン脂質 / 活性型第X因子 / 活性型第IX因子 / 遺伝子治療 / 高機能型 / 細胞・組織 / 機能増強型変異 / 評価方法 / 血液学 / 自動分析装置 / 凝固線溶波形 / 凝固異常症 / 生理学 / von Willebrand 因子 / shear stress / 血管内皮 / 活性化第VII因子 / 活性化・不活性化 / plasmin / clotting function / inactivation / activation / factor VIII / hemophilia A / thrombin generation / clot waveform analysis / 凝固加速度 / 凝固速度 / 止血モニタリング / 組織因子 / プラスミン / 不活性化 / 活性化 / トロンビン生成 / confocal microscopy / flow chamber / physiologic blood flow / blood coagulation / platelet thrombus formation / 血小板 / 共焦点顕微鏡 / フローチャンバー / 生理的血流 / 血小板血栓形成 / フォン・ヴィレブランド病 / ヴォン・ヴィレブランド病 / 血栓 / ずり応力 / 第V因子 / 活性化プロテインC抵抗性 / von willebrand factor / 抗リン脂質抗体 / 抑制メカニズム / 小児 / APC抵抗性 / 凝固第V因子 Less
  • Research Projects

    (28 results)
  • Research Products

    (365 results)
  • Co-Researchers

    (19 People)
  •  Basic research for the development of new therapeutic agents for hemophilia A and thrombophilia based on the regulation of blood coagulation factor VIIIPrincipal Investigator

    • Principal Investigator
      野上 恵嗣
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  生体内病的環境下における血友病Aの病態解析と凝血学特性に基づく新規治療戦略の開発

    • Principal Investigator
      矢田 弘史
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  脾臓内・外の抗FVIII応答制御による血友病Aインヒビター産生消失への挑戦

    • Principal Investigator
      小田 朗永
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  血友病Aとフォンウィルブランド病治療薬の半減期を規定するクリアランス受容体の探索

    • Principal Investigator
      荻原 建一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  Basic research on development of novel therapeutic products for hemophilia A and thrombotic disorders based on the regulation of factor VIII function in the blood coagulationPrincipal Investigator

    • Principal Investigator
      Nogami Keiji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  Identification of the splenic plasma cells niche that regulate inhibitor production in mice with hemophilia A

    • Principal Investigator
      Oda Akihisa
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  血友病A患者・保因者の第Ⅷ因子遺伝子型に基づく病態解析と新規個別化治療戦略の開発

    • Principal Investigator
      矢田 弘史
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
      National Hospital Organization Osaka National Hospital Institute for Clinical Reserch
  •  Development of a new rapid diagnostic method and early phase pathology analysis in coagulation fibrinolysis disorders

    • Principal Investigator
      Matsumoto Tomoko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Tenri University
      Tenri Health Care University
  •  活性化プロテインCおよびプロテインS制御による安定化第VIII因子製剤の開発

    • Principal Investigator
      武山 雅博
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Nara Medical University
  •  Establishment of the novel tailored therapy for the thrombosis of pediatric cancer based on the balance between coagulation and fibrinolysis

    • Principal Investigator
      Takashi Ishihara
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  Development of novel therapeutic strategy based on hemostatic characteristics of FVIII in the patients with moderate/mild hemophilia A

    • Principal Investigator
      Yada Koji
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  Identification of mechanism of FVIII-regulated blood coagulation and development on novel therapeutic drugs for hemophilia A and thrombotic diseasePrincipal Investigator

    • Principal Investigator
      NOGAMI KEIJI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Nara Medical University
  •  Regulation of factor VIII by activated protein C and protein S

    • Principal Investigator
      Takeyama Masahiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  The response of endothelial cells and the function of coagulation factor VIII under flow conditions

    • Principal Investigator
      Shida Yasuaki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Produce of novel regimens that clarify coagulation inhibitory mechanisms for acquired coagulation disorders

    • Principal Investigator
      Matsumoto Tomoko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tenri Health Care University
      Nara Medical University
  •  Molecular biological analysis of single nucleotide polymorphisms in the D'D3 domain of von Willebrand factor

    • Principal Investigator
      Ogiwara Kenichi
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Studies on molecular pathology of hemophilia A and gain-of-function of FVIII

    • Principal Investigator
      Midori Shima
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapyPrincipal Investigator

    • Principal Investigator
      Nogami Keiji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Basic research on establishment of a novel hemostatic treatment based on the hemostatic potential for mild hemophilia A with inhibitor

    • Principal Investigator
      Yada Koji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Research for the regulation of factor VIII by activated protein C and protein S

    • Principal Investigator
      TAKEYAMA MASAHIRO
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Regulation of the function of endothelial cells by shear stress

    • Principal Investigator
      shida yasuaki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Demonstration of global coagulation assays and the suppression mechanism about acquired coagulation disorders

    • Principal Investigator
      Matsumoto Tomoko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapyPrincipal Investigator

    • Principal Investigator
      NOGAMI KEIJI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  第V因子の抗凝固機能と小児血栓性疾患との関連についての基礎的研究

    • Principal Investigator
      Ogiwara Kenichi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Studies on the mechanisms of activation and inactivation of factor VIII : Applications of novel(anti-) coagulant therapyPrincipal Investigator

    • Principal Investigator
      NOGAMI Keiji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Studies on the mechanisms of activation and inactivation of factor VIII : applications of novel coagulant and anticoagulant therapyPrincipal Investigator

    • Principal Investigator
      NOGAMI Keiji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Study on the clotting function by clot waveform analysis

    • Principal Investigator
      SHIMA Midori
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Nara Medical University
  •  Clarification of mechanisms for thrombus formation under physiologic blood flow

    • Principal Investigator
      SUGIMOTO Mitsuhiko
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nara Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book Patent

  • [Book] 【新生児・小児の血栓症とDIC】血栓症の凝固機能と診断 小児がん関連の凝固障害症の研究から2019

    • Author(s)
      石原 卓、野上 恵嗣
    • Total Pages
      8
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Book] 【小児の救急・搬送医療】病態と疾患 血液・腫瘍 播種性血管内凝固(DIC)2019

    • Author(s)
      石原 卓、野上 恵嗣
    • Total Pages
      5
    • Publisher
      東京医学社
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Book] 臨床に直結する血栓止血学2018

    • Author(s)
      野上 恵嗣、松本 智子
    • Total Pages
      686
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Book] 第VIII因子と第V因子の基礎と臨床 新・血栓止血血管学 凝固と炎症2015

    • Author(s)
      野上恵嗣
    • Total Pages
      13
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Book] 臨床に直結する血栓止血学-第VIII因子インヒビター、第IX因子インヒビター2013

    • Author(s)
      松本 智子、 野上 恵嗣
    • Total Pages
      2
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Book] Annual Review血液20132013

    • Author(s)
      野上恵嗣
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Book] 第VIII因子と血液凝固制御―第VIII因子の機能・構造に関する最近の知見2012

    • Author(s)
      野上恵嗣
    • Total Pages
      6
    • Publisher
      医学のあゆみ(医歯薬出版)
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Book] 血栓と循環「血液凝固反応の内因系と外因系は、現在どのように考えられているのですか?」2011

    • Author(s)
      野上恵嗣
    • Total Pages
      2
    • Publisher
      メディカルレビュ社
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] 血栓と循環「血栓症に関するQ&A」2011

    • Author(s)
      野上恵嗣
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] 小児科診療ガイド「von Willebrand病」2011

    • Author(s)
      野上恵嗣、嶋緑倫
    • Total Pages
      4
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] 「小児の診療のしかた-あなたの疑問に答えます」出血傾向を認める患児のスクリーニング検査は何を行いますか?2011

    • Author(s)
      野上恵嗣
    • Publisher
      小児内科
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] 血液疾患血液凝固異常小児科学レビュー2010

    • Author(s)
      野上恵嗣, 嶋緑倫
    • Total Pages
      111
    • Publisher
      総合医学社
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] Clinical and Laboratory Examination in Hemophilia Sysmex2010

    • Author(s)
      Nogami Keiji, Shima Midori
    • Publisher
      シスメックス
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] 小児疾患診療のための病態生理2血友病.小児内科2009

    • Author(s)
      野上恵嗣, 嶋緑倫
    • Total Pages
      1124
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] 血友病に対する適切な治療.臨床に直結する血液疾患診療のエビデンス2009

    • Author(s)
      野上恵嗣, 嶋緑倫
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Book] 血友病A-第VIII因子の分子生物学的診断の進歩. Annual Review 2009血液2009

    • Author(s)
      野上恵嗣
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] The role of proteolytic cleavage at Arg336 and Arg372 of the A1 domain in factor VIIa/tissue factor-catalyzed reactions of B domain-deleted factor VIII2024

    • Author(s)
      Nakajima Y, Nogami K.
    • Journal Title

      Biochim Biophys Acta Gen Subj.

      Volume: 1868 Issue: 1 Pages: 130501-130501

    • DOI

      10.1016/j.bbagen.2023.130501

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Journal Article] The emicizumab-bridged ternary complex with activated factor IX and factor X evaluated by fluorescence resonance energy transfer2024

    • Author(s)
      Oda A, Takeyama M, Kitazawa T, Nogami K.
    • Journal Title

      Thromb Res.

      Volume: 237 Pages: 108-111

    • DOI

      10.1016/j.thromres.2024.03.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Journal Article] Hybrid human-porcine factor VIII proteins partially escape the inhibitory effects of anti-factor VIII inhibitor alloantibodies having A2 or C2 domain specificity2024

    • Author(s)
      Mizumachi K, Nakajima Y, Shimonishi N, Furukawa S, Ogiwara K, Takeyama M, Nogami K.
    • Journal Title

      Haemophilia

      Volume: 30 Issue: 1 Pages: 140-150

    • DOI

      10.1111/hae.14911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Journal Article] Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential.2023

    • Author(s)
      Nakajima Y, Takeyama M, Oda A, Shimonishi N, Nogami K.
    • Journal Title

      Blood Advances

      Volume: 7 Issue: 8 Pages: 14361445-14361445

    • DOI

      10.1182/bloodadvances.2022008187

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K15928, KAKENHI-PROJECT-21K07804, KAKENHI-PROJECT-21K07825
  • [Journal Article] The spleen is the major site for the development and expansion of inhibitor producing-cells in hemophilia A mice upon FVIII infusion developing high-titer inhibitor2023

    • Author(s)
      Akihisa Oda, Shoko Furukawa, Masahiro Kitabatake, Noriko Ouji-Sageshima, Shota Sonobe, Kaoru Horiuchi, Yuto Nakajima, Kenichi Ogiwara, Ryo Goitsuka, Midori Shima, Toshihiro Ito, Keiji Nogami
    • Journal Title

      Thrombosis research

      Volume: 3848 Pages: 00077-4

    • DOI

      10.1016/j.thromres.2023.03.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07825, KAKENHI-PROJECT-21K07246, KAKENHI-PROJECT-21H02372
  • [Journal Article] Factor VIII A3 domain residues 1793-1795 represent a factor IXa-interactive site in the tenase complex2023

    • Author(s)
      Takeyama M, Furukawa S, Sasai K, Horiuchi K, Nogami K.
    • Journal Title

      Biochim Biophys Acta Gen Subj.

      Volume: 1867 Issue: 8 Pages: 130381-130381

    • DOI

      10.1016/j.bbagen.2023.130381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Journal Article] Comparisons of global coagulation potential and bleeding episodes in emicizumab-treated hemophilia A patients and mild hemophilia A patients2022

    • Author(s)
      Yuto Nakajima, Kuniyoshi Mizumachi, Naruto Shimonishi, Shoko Furukawa, Koji Yada, Kenichi Ogiwara, Masahiro Takeyama, Midori Shima, Keiji Nogami
    • Journal Title

      International Journal of Hematology

      Volume: 115 Issue: 4 Pages: 489-498

    • DOI

      10.1007/s12185-021-03276-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07856
  • [Journal Article] A case of a young boy with hyper-fibrinolysis associated with natural fibrin precipitates suspected to have occurred through a novel coagulation and fibrinolysis mechanism2022

    • Author(s)
      Nishiyama A, Ogiwara K, Nakajima Y, Furukawa S, Matsumoto T, Takeda H, Nogami K.
    • Journal Title

      Int J Hematol.

      Volume: 116(2) Issue: 2 Pages: 276-287

    • DOI

      10.1007/s12185-022-03339-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09089
  • [Journal Article] Characterization of thrombophilia-related plasmas evaluated by anticoagulants-mediated thrombin and plasmin generation assays2022

    • Author(s)
      Hashimoto N, Ogiwara K, Matsumoto T, Furukawa S, Takeyama M, Nogami K
    • Journal Title

      Blood Coagul Fibrinolysis

      Volume: 1;33(6) Issue: 6 Pages: 327-336

    • DOI

      10.1097/mbc.0000000000001148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09089
  • [Journal Article] Longitudinal profiling of anti-factor VIII antibodies in Japanese patients with congenital hemophilia A during factor VIII2022

    • Author(s)
      Yoshimura T, Furukawa S, Oda A, Matsumoto T, Sasai K, Shima M, Nogami K.
    • Journal Title

      Int J Hematol.

      Volume: 116(3) Issue: 3 Pages: 423-433

    • DOI

      10.1007/s12185-022-03359-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09089
  • [Journal Article] Comprehensive blood coagulation potential in patients with acquired hemophilia A: retrospective analyses of plasma samples obtained from nationwide centers across Japan2022

    • Author(s)
      Takeyama M, Sasai K, Matsumoto T, Furukawa S, Ogiwara K, Yada K, Onishi T, Shima M, Nogami K
    • Journal Title

      Int J Hematol.

      Volume: 115(2) Issue: 2 Pages: 163-172

    • DOI

      10.1007/s12185-021-03249-w

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09089
  • [Journal Article] Ex Vivo Prediction of Comprehensive Coagulation Potential Using Simulated Blood Concentrations of Emicizumab in Patients with Acquired Hemophilia A.2021

    • Author(s)
      Takeyama M, Furukawa S, Yada K, Ogiwara K, Shimonishi N, Nakajima Y, Mizumachi K, Noguchi-Sasaki M, Shima M, Nogami K.
    • Journal Title

      Thromb Haemost.

      Volume: 121 Issue: 10 Pages: 1289-1298

    • DOI

      10.1055/s-0041-1725009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Journal Article] Coagulation and fibrinolysis balance in disseminated intravascular coagulation2021

    • Author(s)
      Ohnishi Tomoko、Ishihara Takashi、Nogami Keiji
    • Journal Title

      Pediatrics International

      Volume: - Issue: 11 Pages: 1311-1318

    • DOI

      10.1111/ped.14684

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-18K15726
  • [Journal Article] Liver transplantation for congenital protein C deficiency with initial poor graft function: a case report with literature review2021

    • Author(s)
      Sakamoto Atsushi、Ishiguro Akira、Fukuda Akinari、Sakamoto Seisuke、Suenobu So-ichi、Matsumoto Tomoko、Nogami Keiji、Ohga Shouichi、Kasahara Mureo
    • Journal Title

      International Journal of Hematology

      Volume: - Issue: 1 Pages: 141-145

    • DOI

      10.1007/s12185-021-03103-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07822, KAKENHI-PROJECT-21K09089
  • [Journal Article] The C-terminal acidic region in the A1 domain of factor VIII facilitates thrombin-catalyzed activation and cleavage at Arg 3722021

    • Author(s)
      Nakajima Y, Nogami K
    • Journal Title

      J Thromb Haemost.

      Volume: 19 Issue: 3 Pages: 677-688

    • DOI

      10.1111/jth.15201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-21K07804
  • [Journal Article] Inhibitor Index in the Clot Waveform Analysis-Based Mixing Test Differentiates among Hemophilia A without and with Inhibitors, and Lupus Anticoagulant.2021

    • Author(s)
      Shimonishi N, Ogiwara K, Oda Y, Kawabe T, Emmi M, Shima M, Nogami K.
    • Journal Title

      Thromb Haemost.

      Volume: 121 Issue: 06 Pages: 792-799

    • DOI

      10.1055/s-0040-1721776

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Journal Article] A Novel Assessment of Factor VIII Activity by Template Matching Utilizing Weighted Average Parameters from Comprehensive Clot Waveform Analysis.2021

    • Author(s)
      Shimonishi N, Ogiwara K, Oda Y, Kawabe T, Okazaki S, Shima M, Nogami K.
    • Journal Title

      Thromb Haemost.

      Volume: 121 Issue: 02 Pages: 164-173

    • DOI

      10.1055/s-0040-1715838

    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Journal Article] Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg16892021

    • Author(s)
      Nakajima Y, Minami H, Nogami K.
    • Journal Title

      Thromb Haemost.

      Volume: - Issue: 10 Pages: 1274-1288

    • DOI

      10.1055/s-0041-1723996

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-21K07804
  • [Journal Article] A Pathological Clarification of Sepsis-Associated Disseminated Intravascular Coagulation Based on Comprehensive Coagulation and Fibrinolysis Function2020

    • Author(s)
      Onishi Tomoko、Nogami Keiji、Ishihara Takashi、Inoue Satoki、Kawaguchi Masahiko、Nishio Kenji、Fukushima Hidetada、Kobayashi Hiroshi、Amano Itsuto、Nishikubo Toshiya、Yamasaki Masaharu、Kasahara Masato、Shima Midori
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 120 Issue: 09 Pages: 1257-1269

    • DOI

      10.1055/s-0040-1713890

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-18K15726
  • [Journal Article] Novel Insights and New Developments Regarding Coagulation Revealed by Studies of the Anti-Factor IXa (Activated Factor IX)/Factor X Bispecific Antibody, Emicizumab.2020

    • Author(s)
      Yada K, Nogami K
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology.

      Volume: 40(5) Issue: 5 Pages: 1148-1154

    • DOI

      10.1161/atvbaha.120.312919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07798
  • [Journal Article] Emicizumab improves the stability and structure of fibrin clot derived from factor VIII‐deficient plasma, similar to the addition of factor VIII2020

    • Author(s)
      Shimonishi Naruto、Nogami Keiji、Ogiwara Kenichi、Matsumoto Tomoko、Nakazawa Fumie、Soeda Tetsuhiro、Hirata Michinori、Arai Nobuo、Shima Midori
    • Journal Title

      Haemophilia

      Volume: オンライン Issue: 3

    • DOI

      10.1111/hae.13961

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Assessment of self‐/parent‐reported quality of life in Japanese children with haemophilia using the Japanese version of KIDSCREEN‐522020

    • Author(s)
      Furuichi Yasuko、Nogami Keiji、Yada Koji、Nezu Satoko、Obayashi Kenji、Saeki Keigo、Kurumatani Norio、Nakajima Mitsuru、Kinoshita Seiji、Shima Midori
    • Journal Title

      Haemophilia

      Volume: 26 Issue: 2 Pages: 243-250

    • DOI

      10.1111/hae.13945

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] lasma-derived factors VIIa and X mixtures (Byclot) significantly improve impairment of coagulant potential ex vivo in plasmas from acquired hemophilia A patients.2020

    • Author(s)
      Ochi S, Takeyama M, Shima M, Nogami K.
    • Journal Title

      Int J Hematol.

      Volume: - Issue: 6 Pages: 779-785

    • DOI

      10.1007/s12185-020-02837-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10125
  • [Journal Article] An anti-factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A.2020

    • Author(s)
      Takeyama M, Nogami K, Matsumoto T, Noguchi-Sasaki M, Kitazawa T, Shima M.
    • Journal Title

      J Thromb Haemost.

      Volume: 18 Issue: 4 Pages: 825-833

    • DOI

      10.1111/jth.14746

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10125
  • [Journal Article] Emicizumab improves ex vivo clotting function in patients with mild/moderate hemophilia A2020

    • Author(s)
      Nakajima Yuto、Nogami Keiji、Yada Koji、Furukawa Shoko、Noguchi-Sasaki Mariko、Hirata Michinori、Shima Midori
    • Journal Title

      Thrombosis and Haemostasis

      Volume: オンライン Issue: 06 Pages: 968-976

    • DOI

      10.1055/s-0040-1710315

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-18K07798
  • [Journal Article] valuation of clinical severity in patients with type 2N von Willebrand disease using microchip-based flow-chamber system.2020

    • Author(s)
      Nakajima Y, Nogami K, Yada K, Kawamura T, Ogiwara K, Furukawa S, Shimonishi N, Takeyama M, Shima M.
    • Journal Title

      Int J Hematol.

      Volume: 111 Issue: 3 Pages: 369-377

    • DOI

      10.1007/s12185-019-02782-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10125, KAKENHI-PROJECT-17K10128
  • [Journal Article] Whole blood ristocetin-induced platelet impedance aggregometry does not reflect clinical severity in patients with type 1 von Willebrand disease. Haemophilia.2019

    • Author(s)
      Nakajima Y, Nogami K, Yada K , Ogiwara K, Furukawa S, Shimonishi N, Shima M.
    • Journal Title

      Haemophilia

      Volume: 25(3) Issue: 3

    • DOI

      10.1111/hae.13725

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07798
  • [Journal Article] Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L‐asparaginase induction therapy in pediatric acute lymphoblastic leukemia2019

    • Author(s)
      Ishihara Takashi、Nogami Keiji、Ochi Satoshi、Ishida Toshiaki、Kosaka Yoshiyuki、Sawada Akihisa、Inoue Masami、Osone Shinya、Imamura Toshihiko、Hosoi Hajime、Shima Midori
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 67 Issue: 1

    • DOI

      10.1002/pbc.28016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-19K08326
  • [Journal Article] Global coagulation function assessed by rotational thromboelastometrypredicts coagulation-steady state in individual hemophilia A patients receiving emicizumab prophylaxis.2019

    • Author(s)
      Yada K , Nogami K, Ogiwara K, Shida Y, Furukawa S, Yaoi H, Takeyama M, Kasai R,Shima M.
    • Journal Title

      International Journal of Haematology

      Volume: 110(4) Issue: 4 Pages: 419-430

    • DOI

      10.1007/s12185-019-02698-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-17K10125, KAKENHI-PROJECT-17K10126
  • [Journal Article] A novel simultaneous clot-fibrinolysis waveform analysis for assessing fibrin formation and clot lysis in haemorrhagic disorders.2019

    • Author(s)
      Nogami K, Matsumoto T, Sasai K, Ogiwara K, Arai N, Shima M.
    • Journal Title

      Br J Haematol.

      Volume: 187 Issue: 4 Pages: 518-529

    • DOI

      10.1111/bjh.16111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10127
  • [Journal Article] Potential role of activated factor VIII (FVIIIa) in FVIIa/tissue factor-dependent FXa generation in initiation phase of blood coagulation.2019

    • Author(s)
      Furukawa S, Nogami K, Ogiwara K, Shima M.
    • Journal Title

      Int J Hematol.

      Volume: 109 Issue: 4 Pages: 390-401

    • DOI

      10.1007/s12185-019-02611-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07885, KAKENHI-PROJECT-17H04231
  • [Journal Article] Emicizumab, the bispecific antibody to factors IX/IXa and X/Xa, potentiates coagulation function in factor XI-deficient plasma in vitro.2019

    • Author(s)
      Minami H, Nogami K, Yada K, Ogiwara K, Furukawa S, Soeda T, Kitazawa T, Shima M.
    • Journal Title

      J Thromb Haemost

      Volume: 17 Issue: 1 Pages: 126-137

    • DOI

      10.1111/jth.14334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Journal Article] Dynamic evaluation of hemostasis in the acute phase of Kawasaki disease using comprehensive coagulation functional assays.2019

    • Author(s)
      Yoshizawa H, Nogami K, Matsumoto T, Tsujii N, Sakai T, Takase T, Tanaka I, Shima M.
    • Journal Title

      Thromb Res.

      Volume: 174 Pages: 76-83

    • DOI

      10.1016/j.thromres.2018.12.016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15684, KAKENHI-PROJECT-17K10127
  • [Journal Article] Spotlight on emicizumab in the management of hemophilia A:patient selection and special considerations.2019

    • Author(s)
      Yada K , Nogami K
    • Journal Title

      Journal of blood medicine

      Volume: 10 Pages: 171-181

    • DOI

      10.2147/jbm.s175952

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07798
  • [Journal Article] Hemostatic function in hyperfibrinolytic disseminated intravascular coagulation2019

    • Author(s)
      Ishihara Takashi、Nogami Keiji、Onishi Tomoko、Ogiwara Kenichi、Ochi Satoshi、Yamazaki Masaharu、Shima Midori
    • Journal Title

      Pediatrics International

      Volume: 61 Issue: 9 Pages: 872-881

    • DOI

      10.1111/ped.13919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Journal Article] A case of moderate haemophilia A with inhibitor, carrying the p.R1800H mutation, complicated with juvenile idiopathic arthritis2018

    • Author(s)
      Yuka Kondo Yasuaki Shida Tomoaki Ishikawa Koji Yada Masahiro Takeyama Midori Shima Keiji Nogami
    • Journal Title

      Haemophilia

      Volume: 25(1) Issue: 1 Pages: 51-54

    • DOI

      10.1111/hae.13648

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17K10125
  • [Journal Article] Factor (F)VIII/VIIa enhances global haemostatic function in the co-presence of bypassing agents and FVIII among patients with haemophilia A with inhibitor2018

    • Author(s)
      Nogami K, Matsumoto T, Yada K, Ogiwara K, Furukawa S, Shida Y, Takeyama M, Shima M
    • Journal Title

      Br J Haematol

      Volume: ahead of printing Issue: 4 Pages: 528-536

    • DOI

      10.1111/bjh.15209

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10126, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07798, KAKENHI-PROJECT-18K07885
  • [Journal Article] New therapies using nonfactor products for patients with hemophilia and inhibitors2018

    • Author(s)
      Nogami Keiji、Shima Midori
    • Journal Title

      Blood

      Volume: 133 Issue: 5 Pages: 399-406

    • DOI

      10.1182/blood-2018-07-820712

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Routine measurements of factor VIII activity and inhibitor titer in the presence of emicizumab utilizing anti-idiotype monoclonal antibodies2018

    • Author(s)
      Nogami K, Soeda T, Matsumoto T, Kawabe Y, Kitazawa T, Shima M
    • Journal Title

      J Thromb Haemost

      Volume: 16(7) Issue: 7 Pages: 1383-1390

    • DOI

      10.1111/jth.14135

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07885
  • [Journal Article] Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation.2018

    • Author(s)
      Narazaki T, Haji S, Nakashima Y, Tsukamoto Y, Tsuda M, Takamatsu A, Ohno H, Matsushima T, Matsumoto T, Nogami K, Shima M, Shiratsuchi M, Ogawa Y
    • Journal Title

      Int J Hematol

      Volume: 108(3) Issue: 3 Pages: 335-338

    • DOI

      10.1007/s12185-018-2441-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Journal Article] Contribution of Factor VIII A2 Domain Residues 400-409 to a Factor X-Interactive Site in the Factor Xase Complex.2018

    • Author(s)
      Takeyama M, Nogami K, Sasai K, Furukawa S, Shima M.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 118 Issue: 05 Pages: 830-841

    • DOI

      10.1055/s-0038-1637745

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Journal Article] Emicizumab-mediated haemostatic function in patients with haemophilia A is down-regulated by activated protein C through inactivation of activated factor V2018

    • Author(s)
      Yada Koji、Nogami Keiji、Shinozawa Keiko、Kitazawa Takehisa、Hattori Kunihiro、Amano Kagehiro、Fukutake Katsuyuki、Shima Midori
    • Journal Title

      British Journal of Haematology

      Volume: 183 Issue: 2 Pages: 257-266

    • DOI

      10.1111/bjh.15525

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Journal Article] Orthotopic liver transplantation for haemophilia A may not always lead to a phenotypic cure of haemophilia A: A case report2018

    • Author(s)
      Suzuki Y, Kakisaka K, Matsumoto T, Nogami K, Katagiri H, Takahara T, Takikawa Y
    • Journal Title

      Haemophilia

      Volume: 24(6)

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Journal Article] First report of real-time monitoring of coagulation function potential and IgG subtype of anti-FVIII autoantibodies in a child with acquired hemophilia A associated with streptococcal infection and amoxicillin2018

    • Author(s)
      Takeyama M, Nogami K, Kajimoto T, Ogiwara K, Matsumoto T, Shima M
    • Journal Title

      Int J Hematol

      Volume: 107(1) Issue: 1 Pages: 112-116

    • DOI

      10.1007/s12185-017-2273-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Journal Article] The factor VIII heavy chain improves emicizumab-tenase assembly to enhance the factor VIII-mimicking cofactor activity.2018

    • Author(s)
      Minami H, Nogami K, Soeda T, Kitazawa T, Hattori K, Shima M.
    • Journal Title

      Thrombosis Research

      Volume: 166 Pages: 77-79

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Journal Article] Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti-factor IXa/factor X bispecific antibody, emicizumab2018

    • Author(s)
      Nogami K, Matsumoto T, Tabuchi Y, Soeda T, Arai N, Kitazawa T, Shima M
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 未定 Issue: 6 Pages: 1078-1088

    • DOI

      10.1111/jth.14022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-18K07885
  • [Journal Article] Potentially life-threatening coagulopathy associated with simultaneous reduction in coagulation and fibrinolytic function in pediatric acute leukemia after hematopoietic stem-cell transplantation.2017

    • Author(s)
      Ishihara T, Nogami K , Matsumoto T, Nomura A, Takeshita Y, Ochi S, Shima M
    • Journal Title

      International Jurnal of Hematology

      Volume: 106(1) Issue: 1 Pages: 126-134

    • DOI

      10.1007/s12185-017-2213-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Journal Article] Successful prophylaxis using activated prothrombin complex concentrates (aPCC) in a severe haemophilia A patient with inhibitor previously unresponsive to on-demand daily infusions of aPCC.2017

    • Author(s)
      Furukawa S, Nogami K, Ogiwara K, Yada K, Shima M.
    • Journal Title

      Haemophilia.

      Volume: 23 Issue: 5

    • DOI

      10.1111/hae.13310

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09663, KAKENHI-PROJECT-15K09664
  • [Journal Article] A combined approach using global coagulation assays quickly differentiates coagulation disorders with prolonged aPTT and low levels of FVIII activity.2017

    • Author(s)
      Tomoko Matsumoto, Keiji Nogami, Midori Shima
    • Journal Title

      International Jurnal of Hematology

      Volume: 105(2) Issue: 2 Pages: 174-183

    • DOI

      10.1007/s12185-016-2108-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10127, KAKENHI-PROJECT-17H04231
  • [Journal Article] Role of red blood cells in the anemia-associated bleeding under high shear conditions2017

    • Author(s)
      H. Yaoi, Y. Shida,, K. Ogiwara, K. Hosokawa, M. Shima and K. Nogami
    • Journal Title

      hemophilia

      Volume: - Issue: 5 Pages: 750-758

    • DOI

      10.1111/hae.13252

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461593, KAKENHI-PROJECT-17K10126
  • [Journal Article] Long-term safety and efficacy of emicizumab in a phase 1/2 study in patients with hemophilia A with or without inhibitors.2017

    • Author(s)
      Shima M, Hanabusa H, Taki M, Matsushita T, Sato T, Fukutake K, Kasai R, Yoneyama K, Yoshida H, Nogami K.
    • Journal Title

      Blood Adv.

      Volume: 1(22) Issue: 22 Pages: 1891-1899

    • DOI

      10.1182/bloodadvances.2017006684

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09902, KAKENHI-PROJECT-17H04231, KAKENHI-PROJECT-15K09663
  • [Journal Article] Clot waveform analysis using CS-2000i distinguishes between very low and absent levels of factor VIII activity in patients with severe hemophilia A2017

    • Author(s)
      Tomoko Matsumoto, Keiji Nogami, Yuka Tabuchi, Koji Yada, Kenichi Ogiwara, Hiroshi Kurono, Nobuo Arai, Midori Shima
    • Journal Title

      Haemophilia

      Volume: 23(5) Issue: 5

    • DOI

      10.1111/hae.13266

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Journal Article] A new parameter in the thrombin generation assay, mean velocity to peak thrombin, reflects factor VIII activity in patients with haemophilia A2016

    • Author(s)
      Takeyama M, Nogami K, Shima M.
    • Journal Title

      Haemophilia

      Volume: 22(5) Pages: 474-477

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016

    • Author(s)
      Nogami K1, Ogiwara K1, Yada K1, Shida Y1, Takeyama, Yaoi H, Minami H, Furukawa S, Hosokawa K, Shima M
    • Journal Title

      J Thromb Haemost

      Volume: 14 Issue: 4 Pages: 667-74

    • DOI

      10.1111/jth.13273

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016

    • Author(s)
      Nogami K, Ogiwara K, Yada K, Shida Y, Takeyama M, Yaoi H, Minami H, Furukawa S, Hosokawa K, Shima M.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 14(4) Pages: 667-674

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Journal Article] The utility of thromboelastography in inherited and acquired bleeding disorders.2016

    • Author(s)
      Keiji Nogami
    • Journal Title

      British Journal of Haematology

      Volume: 174(4) Pages: 503-514

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Journal Article] Assessing the clinical severity of type 1 von Willebrand disease patients with a microchip flow-chamber system.2016

    • Author(s)
      Nogami K, Ogiwara K, Yada K, Shida Y, Takeyama M, Yaoi H, MinamiH, Furukawa S, Hosokawa K, Shima M
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 14(4) Pages: 667-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Journal Article] Successful haemostatic management of replacement of the ascending aorta for type A acute aortic dissection in a patient with mild haemophilia B2016

    • Author(s)
      Takeyama M, Nogami K, Shida Y, Yada K, Hirose T, Hayata Y, Tabayashi N, Taniguchi S, Akasaki Y, Kawaraguchi Y, Kawaguchi M, Shima M
    • Journal Title

      Haemophilia

      Volume: Jan 29 Issue: 2

    • DOI

      10.1111/hae.12879

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] トロンビン生成試験(thrombin generation test)2016

    • Author(s)
      松本 智子、野上 恵嗣
    • Journal Title

      Thrombosis Medicine

      Volume: 6(1) Pages: 55-61

    • Data Source
      KAKENHI-PROJECT-25461605
  • [Journal Article] The utility of VWF multimer analysis in response to the desmopressin administration for the diagnosis of severe type 1 von Willebrand disease.2016

    • Author(s)
      Takeyama M, Nogami K, Onaka M, Yada K, Shida Y, Shima M
    • Journal Title

      Haemophilia

      Volume: Jan 29 Issue: 2

    • DOI

      10.1111/hae.12874

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] フォン・ヴィレブランド病の病態と診療2015

    • Author(s)
      志田 泰明, 野上恵嗣
    • Journal Title

      日本小児血液・がん学会雑誌

      Volume: 52(1) Pages: 1-9

    • NAID

      40020456048

    • Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] FVIIIの生合成およびフォン・ヴィレブランド因子との相互作用に関する最新の知見2015

    • Author(s)
      志田 泰明, 野上恵嗣
    • Journal Title

      日本血栓止血学会誌

      Volume: 26(1) Pages: 49-56

    • NAID

      130004847363

    • Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] 血栓止血性疾患の遺伝子診断―出血性疾患2015

    • Author(s)
      矢田 弘史, 野上 恵嗣
    • Journal Title

      日本血栓止血学会誌

      Volume: 26 Pages: 513-517

    • NAID

      130005102998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Journal Article] プロテインCおよびプロテインSによる凝固第VIII因子の制御機構の解明および新規血友病治療製剤への応用2015

    • Author(s)
      武山雅博、野上恵嗣
    • Journal Title

      母子健康協会小児医学助成研究報告書

      Volume: 1 Pages: 12-13

    • Data Source
      KAKENHI-PROJECT-26461592
  • [Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogeneic but not autologous factor VIII activity.2015

    • Author(s)
      Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 13 Pages: 1843-1853

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Journal Article] Mild hemophilia A patient with novel Pro1809Leu mutation develops an anti-C2 antibody inhibiting allogenic but not autologous factor VIII activity.2015

    • Author(s)
      Yada K, Nogami K, Takeyama M, Ogiwara K, Wakabayashi H, Shima M
    • Journal Title

      J Thromb Haemost

      Volume: 13 Issue: 10 Pages: 1843-1853

    • DOI

      10.1111/jth.13118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09664, KAKENHI-PROJECT-26461592, KAKENHI-PROJECT-25293237
  • [Journal Article] Phenotypic heterogeneity of hemostasis in severe hemophilia2015

    • Author(s)
      Nogami K, Shima M.
    • Journal Title

      Seminars in Thrombosis and Hemostasis

      Volume: 41 Pages: 826-831

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Journal Article] Comprehensive evaluation of haemostatic function in von Willebrand disease patients using a microchip-based flow chamber system2015

    • Author(s)
      Ogiwara K1, Nogami K, Hosokawa K, Ohnishi T, Matsumoto T, Shima M
    • Journal Title

      Hemohilia

      Volume: 21(1) Issue: 1 Pages: 71-80

    • DOI

      10.1111/hae.12610

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry.2015

    • Author(s)
      Furukawa S, Nogami K, Ogiwara K, Yada K, Minami H, Shima M.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 13 Pages: 1279-1284

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Journal Article] Systematic monitoring of hemostatic management in hemophilia A patients with inhibitor in the perioperative period using rotational thromboelastometry.2015

    • Author(s)
      Furukawa S, Nogami K, Ogiwara K, Yada K, Minami H, Shima M.
    • Journal Title

      J Thromb Haemost

      Volume: 13 Issue: 7 Pages: 1279-1284

    • DOI

      10.1111/jth.12987

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Journal Article] Tissue factor pathway inhibitor in activated prothrombin complex concentrates (aPCC) moderates the effectiveness of therapy in some severe hemophilia A patients with inhibitor.2014

    • Author(s)
      Ogiwara K, Nogami K, Matsumoto T, Shima M
    • Journal Title

      Int J Hematol.

      Volume: 99 Pages: 577-587

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Journal Article] Novel FV mutation (W1920R, FVNara) associated with serious deep vein thrombosis and more potent APC resistance relative to FVLeiden2014

    • Author(s)
      Nogami K, Shinozawa K, Ogiwara K, Matsumoto T, Amano K, Fukutake K, Shima M.
    • Journal Title

      Blood

      Volume: 2420-8 Issue: 15 Pages: 2420-8

    • DOI

      10.1182/blood-2013-10-530089

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] Novel FV mutation (W1920R, FVNara) associated with serious deep vein thrombosis and more potent APC resistance relative to FVLeiden.2014

    • Author(s)
      Nogami K, Shinozawa K, Ogiwara K, Matsumoto T, Amano K, Fukutake K, Shima M.
    • Journal Title

      Blood

      Volume: 10; 123(15) Issue: 2 Pages: 2420-2428

    • DOI

      10.1007/s12185-014-1720-x

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461605, KAKENHI-PROJECT-26461593
  • [Journal Article] フォン・ヴィレブランド病の分子生物学的診断と診療への応用2014

    • Author(s)
      志田 泰明, 野上恵嗣
    • Journal Title

      日本血栓止血学会誌

      Volume: 25(4)

    • NAID

      130004687765

    • Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] Coagulation function and mechanisms in various clinical phenotypes of patients with acquired factor V inhibitors2014

    • Author(s)
      Matsumoto T, Nogami K, Shima M.
    • Journal Title

      J Thromb Haemost

      Volume: 12(9) Issue: 9 Pages: 1503-12

    • DOI

      10.1111/jth.12660

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] The first case of int1h-related inversion in Japanese haemophilia A patients.2014

    • Author(s)
      Yada K, Nogami K, Kawamura T, Minami H, Shima M
    • Journal Title

      Haemophilia

      Volume: 20(6) Issue: 6

    • DOI

      10.1111/hae.12509

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25860878, KAKENHI-PROJECT-26461593
  • [Journal Article] Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A2014

    • Author(s)
      Muto A, Yoshihashi K, Takeda M, Kitazawa T, Soeda T, Igawa T, Sampei Z, Kuramochi T, Sakamoto A, Haraya K, Adachi K, Kawabe Y, Nogami K, Shima M, Hattori K.
    • Journal Title

      Blood

      Volume: 124(20) Issue: 20 Pages: 3165-71

    • DOI

      10.1182/blood-2014-07-585737

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] Optimal monitoring of bypass therapy in hemophilia A patients with inhibitors by the use of clot waveform analysis2014

    • Author(s)
      Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M.
    • Journal Title

      J Thromb Haemost

      Volume: 12(3) Issue: 3 Pages: 355-62

    • DOI

      10.1111/jth.12488

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Journal Article] Optimal monitoring of bypass therapy in hemophilia A patients with inhibitors by the use of clot waveform analysis.2014

    • Author(s)
      Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M
    • Journal Title

      J Thromb Haemost.

      Volume: 12 Pages: 355-362

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Journal Article] 血友病A の分子病態の進歩 - 第VIII 因子構造・機能からみた病態2014

    • Author(s)
      野上恵嗣
    • Journal Title

      日本小児血液・がん学会雑誌

      Volume: 51 Pages: 452-458

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Journal Article] 1.症例から学ぶ止血凝固検査2014

    • Author(s)
      松本 智子、野上 恵嗣
    • Journal Title

      日本検査血液学会雑誌

      Volume: 15(2) Pages: 233-239

    • Data Source
      KAKENHI-PROJECT-25461605
  • [Journal Article] 血液凝固の動的把握と血友病診療の進歩2014

    • Author(s)
      野上恵嗣
    • Journal Title

      血栓止血誌

      Volume: 25 Pages: 371-379

    • NAID

      130004847325

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Journal Article] Tissue factor pathway inhibitor in activated prothrombin complex concentrates (aPCC) moderates the effectiveness of therapy in some severe hemophilia A patients with inhibitor.2014

    • Author(s)
      Ogiwara K, Nogami K, Matsumoto T, Shima M.
    • Journal Title

      International Journal of Hematology

      Volume: 99 Issue: 5 Pages: 577-587

    • DOI

      10.1007/s12185-014-1572-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461605, KAKENHI-PROJECT-26461593
  • [Journal Article] Coagulation function and mechanisms in various clinical phenotypes of patients with acquired factor V inhibitors.2014

    • Author(s)
      Matsumoto T, Nogami K, Shima M.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 12 Pages: 1503-1512

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Journal Article] Optimal monitoring of bypass therapy in hemophilia A patients with inhibitors by the use of clot waveform analysis.2014

    • Author(s)
      Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 12(3) Pages: 355-362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Journal Article] 後天性凝固因子インヒビターの基礎と病態2013

    • Author(s)
      野上恵嗣
    • Journal Title

      臨床血液

      Volume: 54(10) Pages: 361-368

    • NAID

      10031196336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Journal Article] Different factor VIII neutralizing effects on anti-factor VIII inhibitor antibodies associated with epitope specificity and von Willebrand factor.2013

    • Author(s)
      Yada K, Nogami K, Shima M.
    • Journal Title

      British Journal of Haematology

      Volume: 163(1) Issue: 1 Pages: 104-111

    • DOI

      10.1111/bjh.12473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
  • [Journal Article] Activated prothrombin complex concentrate (APCC)-mediated activation of factor (F)VIII in mixtures of FVIII and APCC enhances hemostatic effectiveness.2013

    • Author(s)
      Yada K, Nogami K, Ogiwara K, Shima M
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 11(5) Issue: 5 Pages: 902-910

    • DOI

      10.1111/jth.12197

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
  • [Journal Article] Simultaneous measurement of thrombin and plasmin generation to assess the interplay between coagulation and fibrinolysis.2013

    • Author(s)
      Matsumoto T, Nogami K, Shima M.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 110 Pages: 761-768

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Journal Article] 新規凝固機能検査による評価;T-TAS®とトロンビン生成試験(TGT)の基本と臨床2013

    • Author(s)
      松本 智子、野上 恵嗣、嶋 緑倫。
    • Journal Title

      日本検査血液学会雑誌

      Volume: 第14巻 第3号 Pages: 365-372

    • Data Source
      KAKENHI-PROJECT-25461605
  • [Journal Article] Simultaneous measurement of thrombin and plasmin generation to assess the interplay between coagulation and fibrinolysis.2013

    • Author(s)
      Matsumoto T, Nogami K, Shima M.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 110(4) Issue: 10 Pages: 761-768

    • DOI

      10.1160/th13-04-0345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Journal Article] The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X.2013

    • Author(s)
      Yada K, Nogami K, Wakabayashi H, Fay PJ, Shima M.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 109(6) Issue: 06 Pages: 1007-1015

    • DOI

      10.1160/th12-10-0762

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558, KAKENHI-PROJECT-25860878
  • [Journal Article] A putative inhibitory mechanism in the tenase complex responsible for loss of coagulation function in acquired haemophilia A patients with anti-C2 autoantibodies.2012

    • Author(s)
      Matsumoto T, Nogami K, Ogiwara K, Shima M.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 107 Issue: 02 Pages: 288-301

    • DOI

      10.1160/th11-05-0331

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Journal Article] Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII2011

    • Author(s)
      Yada K, Nogami K, 他3名
    • Journal Title

      Thromb Haemost

      Volume: 105 Pages: 989-98

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a)2011

    • Author(s)
      Nogami K, Ogiwara K, et al
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 105 Pages: 968-980

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Mechanisms of human neutrophil elastase-catalysed inactivation of factor VIII(a)2011

    • Author(s)
      Nogami K, Ogiwara K, 他4名
    • Journal Title

      Thromb Haemost

      Volume: 105 Pages: 968-80

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalysed activation and inactivation of factor VIII2011

    • Author(s)
      Yada K, Nogami K (corresponding author), et al
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 105 Pages: 989-998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Interactions between residues 2228-2240 within factor VIIIa C2 domain and factor IXa Gla domain contribute to propagation of clot formation2011

    • Author(s)
      Soeda T, Nogami K, 他2名
    • Journal Title

      Thromb Haemost

      Volume: 106 Pages: 893-900

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Interactions between residues 2228-2240 within factor VIIIa C2 domain and factor IXa Gla domain contribute to propagation of clot formation2011

    • Author(s)
      Soeda T, Nogami K,(corresponding author), et al
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 106 Pages: 893-900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Effects of anti-factor VIII inhibitor antibodies on factor VIIa/tissue factor-catalyzed activation and inactivation of factor VIII2011

    • Author(s)
      Yada K, Nogami K (corresponding author), et al.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Factor VIII activation by factor VIIa analog (V158D/E296V/M298Q) in tissue factor-independent mechanisms2011

    • Author(s)
      Ogiwara K, Nogami K (corresponding author), et al
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 106 Pages: 665-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Factor VIII activation by factor VIIa analog(V158D/E296V/M298Q) in tissue factor independent mechanisms2011

    • Author(s)
      Ogiwara K, Nogami K, 他1名
    • Journal Title

      Thromb Haemost

      Volume: 106 Pages: 665-74

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010

    • Author(s)
      Nishiya K, Nogami K (corresponding author), et al.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 104 Pages: 105-117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII2010

    • Author(s)
      Soeda T, Nogami K, 他3名
    • Journal Title

      J Thromb Haemost

      Volume: 8 Pages: 2494-503

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Determination of a factor VIII interactive region within plasmin responsible for plasmin-catalysed activation and inactivation of factor VIII(a)2010

    • Author(s)
      Nishiya K, Nogami K, 他5名
    • Journal Title

      Thromb Haemost

      Volume: 104 Pages: 105-17

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Characterization of an antibody specific for coagulation factor VIII that enhances factor VIII(a)activity2010

    • Author(s)
      Takeyama M, Nogami K(corresponding author), et al.
    • Journal Title

      Thrombosis and Haemostasis 103

      Pages: 94-102

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Mechanisms of factor VIIa-catalyzed activation of factor VIII2010

    • Author(s)
      Soeda T, Nogami K (correspondingauthor), et al.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 8 Pages: 2494-2503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Determination of a factor VIII-interactive region within plasmin responsible for plasmin-catalyzed activation and inactivation of factor VIII(a)2010

    • Author(s)
      Nishiya K, Nogami K(corresponding author), et al.
    • Journal Title

      Thrombosis and Haemostasis (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Plasmin-induced procoagulant effects in the blood coagulation : a crucial role of coagulation factors V and VIII2010

    • Author(s)
      Ogiwara K, Nogami K (corresponding author), et al.
    • Journal Title

      Blood Coagulation and Fibrinolysis

      Volume: 21 Pages: 768-776

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Plasmin induced procoagulant effects in the blood coagulation : a crucial role of coagulation factors V and VIII2010

    • Author(s)
      Ogiwara K, Nogami K, 他2名
    • Journal Title

      Blood Coagul Fibrinolysis

      Volume: 21 Pages: 568-76

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity2010

    • Author(s)
      Takeyama M, Nogami K, 他5名
    • Journal Title

      Thromb Haemost

      Volume: 103 Pages: 94-102

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex2009

    • Author(s)
      Soeda T, Nogami K, et.al.(他6名)
    • Journal Title

      J Biol Chem 284

      Pages: 3379-88

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] A modified thrombin generation test for investigating very low levels of factor VIII activity in hemophilia A2009

    • Author(s)
      Matsumoto T, Nogami K, 他2名
    • Journal Title

      Int J Hematol

      Volume: 90 Pages: 576-82

    • NAID

      10026109911

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor xase complex.2009

    • Author(s)
      Soeda T, Nogami K. (corresponding author), et al.
    • Journal Title

      The Journal of Biological Chemistry 284

      Pages: 3379-3388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a protein S interactive site within the A2 domain of the factor VIII heavy chain2009

    • Author(s)
      Takeyama M, Nogami K, 他3名
    • Journal Title

      Thromb Haemost

      Volume: 102 Pages: 645-55

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] von Willebrand factor protects the Ca2+-dependent structure of the factor VIII light chain2009

    • Author(s)
      Takeyama M, Nogami K(corresponding author), et al.
    • Journal Title

      British Journal of Haemotology 146

      Pages: 531-536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys362009

    • Author(s)
      Nogami K. (1^<st> author), et al.
    • Journal Title

      The Journal of Biological Chemistry In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a protein S-interactive site within the A2 domain of the factor VIII heavy chain2009

    • Author(s)
      Takeyama M, Nogami K(corresponding author), et al.
    • Journal Title

      Thrombosis and Haemostasis 102

      Pages: 645-655

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] A modified thrombin generation test for investigating very low levels of factor VIII activity in hemophilia A2009

    • Author(s)
      Matsumoto T, Nogami K(corresponding author), et al.
    • Journal Title

      International Journal of Haemotology 90

      Pages: 576-582

    • NAID

      10026109911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] The factor VIIIa C2 domain(residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex2009

    • Author(s)
      Soeda T, Nogami K, 他6名
    • Journal Title

      J Biol Chem

      Volume: 284 Pages: 3379-88

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys362009

    • Author(s)
      Nogami K, Nishiya K, et.al.(他5名)
    • Journal Title

      J Biol Chem 284

      Pages: 6934-45

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys362009

    • Author(s)
      Nogami K, 他6名
    • Journal Title

      J Biol Chem

      Volume: 284 Pages: 6934-45

    • Data Source
      KAKENHI-PROJECT-21591370
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008

    • Author(s)
      Nogami K. (1^<st> author), et al.
    • Journal Title

      Biochemical Biochimica et Acta 1784

      Pages: 753-763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Protein S down-regulates factor Xase activity independent of activated protein C : specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa2008

    • Author(s)
      Takeyama M, Nogami K. (corresponding author), et al.
    • Journal Title

      British Journal of Hematology 143

      Pages: 409-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg3722008

    • Author(s)
      Nogami K, Saenko EL, et.al.(他4名)
    • Journal Title

      Br J Haematol 140

      Pages: 433-43

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Selective factor VIII and V inactivation by iminodiacetate ion exchange resin through metal ion adsorption2008

    • Author(s)
      Takeyama M, Nogami K, et.al.(他5名)
    • Journal Title

      Br J Haematol 142

      Pages: 962-70

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008

    • Author(s)
      Nogami K, Shima M, et.al.(他5名)
    • Journal Title

      Biochim Biophys Acta 1784

      Pages: 753-63

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a thrombin-interactive site with in the factor VIII A2 domain that is responsible for the cleavage at Arg3722008

    • Author(s)
      Nogami K.(1^<st> author), et. al.
    • Journal Title

      British Journal of Hematology 140

      Pages: 433-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a plasmin-interactive site with in the A2 domain of the factor VIII heavy chain2008

    • Author(s)
      Nogami K.(1^<st> author), et. al.
    • Journal Title

      Biochemical Biochimica et Acta In press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Selective factor VIII and V inactivation by iminodiacetate ion exchange resin through metal ion adsorption2008

    • Author(s)
      Takeyama M, Nogami K. (corresponding author), et al.
    • Journal Title

      British Journal of Hematology 142

      Pages: 962-970

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008

    • Author(s)
      Nogami K, Nishiya K, Shima M, et. al.
    • Journal Title

      Biochimica et Biophysica Acta (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2008

    • Author(s)
      Nogami K, Yoshioka A, Shima M, et. al.
    • Journal Title

      Britishi Journal of Haematology 140

      Pages: 433-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Protein S down-regulates factor Xase activity independent of activated protein C : specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa2008

    • Author(s)
      Takeyama M, Nogami K, et.al.(他5名)
    • Journal Title

      Br J Haematol 143

      Pages: 409-20

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Identification of a thrombin-interactive site within the factor VIII A2 domain that is responsible for the cleavage at Arg3722008

    • Author(s)
      Nogami K. (1^<st> author), et al.
    • Journal Title

      British Journal of Hematology 140

      Pages: 433-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII : a crucial role for proteolytic cleavage at Arg^<336> responsible for plasmin-catalyzed factor VIII inactivation2007

    • Author(s)
      Nogami K, Shima M, et al.
    • Journal Title

      Journal of Biological Chemistry 282(8)

      Pages: 5287-5295

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M et.al.(他4名)
    • Journal Title

      Int J Hematol 85

      Pages: 317-22

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] 血友病Aの分子病態. 第VIII因子の分子構造および機能の最近の知見2007

    • Author(s)
      野上恵嗣
    • Journal Title

      血栓止血誌 19

      Pages: 779-87

    • NAID

      10026116902

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid,and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII : A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Relationship between the binding sites for von Willebrand factor,phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 doma in2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama M, Tanaka I, Yoshioka A.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007

    • Author(s)
      Nogami K, Saenko EL, Takeyama M, Giddings JC, Yoshioka A, Shima M.
    • Journal Title

      British Journal of Haematology 140

      Pages: 433-443

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg(372)2007

    • Author(s)
      Nogami K, Saenko, EL, Takeyama M, Shima M, et. al.
    • Journal Title

      British Journal of Haematology 140

      Pages: 433-443

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII: A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation.2007

    • Author(s)
      Nogami K, Shima M, Matsumoto T, Nishiya K, Tanaka I, Yoshioka A.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Mechanisms of plasmin-catallyzed inzctivation of fctor VIII:a crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation2007

    • Author(s)
      Nogami K. (1^<st> author), et. al.
    • Journal Title

      The Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Mechanisms of Plasmin-catalyzed inactivation of factor VIII:A crucial role for proteolytic cleavage at Arg336 responsible for plasmin-catalyzed factor VIII inactivation2007

    • Author(s)
      Nogami K, Shima M, Matsumoto T, et. al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 5287-5295

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Heparin-induced inhibitory effets of a prothrombin complex concentrate on global tests of haemostasis2007

    • Author(s)
      Takeyama M, Sakurai Y, shima M Matsumoto T, Nogami K, et. al.
    • Journal Title

      Blood Coagulation & Fibrinolysis 18

      Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, et al.
    • Journal Title

      International Journal of Hematology (in press)

    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies with in the factor VIII C2 domain2007

    • Author(s)
      Nogami K.(1^<st> author), et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII2007

    • Author(s)
      Nogami K, Shima M, et.al.(他4名)
    • Journal Title

      J Biol Chem 282

      Pages: 5287-95

    • Data Source
      KAKENHI-PROJECT-19591264
  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M, Giddings JC, Takeyama, et. al.
    • Journal Title

      International Journal of Hematology 85

      Pages: 317-322

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for throm bin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, Nogami K, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 1354-1360

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Factor V C2 domain contains a major thrombin-binding site resposible for thrombin-catalyzed factor V activation2006

    • Author(s)
      Suzuki H, Shima M, Nogami K, et. al.
    • Journal Title

      Journal of Thrombosis and Haemostasis 4

      Pages: 1354-1360

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain

    • Author(s)
      Nogami K, Nishiya K, Shima M, et. al.
    • Journal Title

      Biochimica et Biophysica Acta (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Patent] 血液検体の凝固能の評価方法、並びにその方法に用いるための試薬、試薬キットおよび装置2015

    • Inventor(s)
      嶋緑倫、野上恵嗣、松本智子、北沢剛久、添田哲弘、池田有香
    • Industrial Property Rights Holder
      嶋緑倫、野上恵嗣、松本智子、北沢剛久、添田哲弘、池田有香
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-04-24
    • Acquisition Date
      2016-03-30
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Patent] 血液凝固第VIII因子の活性を促進する抗体2006

    • Inventor(s)
      武山 雅博、野上 恵嗣、嶋 緑倫、鈴木 司
    • Industrial Property Rights Holder
      中外製薬
    • Industrial Property Number
      2006-235776
    • Filing Date
      2006-08-31
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Establishment of the mouse model with mild/moderate hemophilia A inducible the neutralizing anti-FVIII alloantibodies2024

    • Author(s)
      小田朗永, 古川晶子, 垣本月海, 西村惠子, 野上恵嗣
    • Organizer
      第52回日本免疫学会学術集会,
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] DDAVP-trial has a possible role for auxiliary diagnosis in type 1 and type 2 von Willebrand disease.2023

    • Author(s)
      Kenichi Ogiwara, Naruto Shimonishi, Yuto Nakajima, Shoko Furukawa, Masahiro Takeyama, Masaki Hayakawa, Masanori Matsumoto, Keiji Nogami
    • Organizer
      The XXXI Congress of the International Society on Thrombosis and Haemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10128
  • [Presentation] 蛍光共鳴エネルギー移動を用いたEmicizumabと活性型第IX因子及び第X因子との三元複合体の評価2023

    • Author(s)
      武山雅博, 小田朗永, 北沢剛久, 野上恵嗣
    • Organizer
      第45回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] in vitro培養系による抗FVIII応答の誘導2023

    • Author(s)
      小田朗永, 古川晶子, 北畠正大, 王寺典子, 堀内薫, 笹井香那, 下西成人, 中島由翔, 荻原建一, 武山雅博, 伊藤利洋, 嶋緑倫, 野上恵嗣
    • Organizer
      第45回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] Induction of anti-factor VIII immune response in hemophilia A mouse model retaining humanized immune system.2023

    • Author(s)
      小田朗永, 古川晶子, 北畠正大, 王寺典子, 高橋利一, 荻原建一, 伊藤利洋, 嶋緑倫, 野上恵嗣
    • Organizer
      第85回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] 寛解導入療法時に包括的な凝固線溶動態解析を行ったKMT2A遺伝子再構成陽性急性リンパ性白血病(KMT2A-r ALL)の1乳児例2022

    • Author(s)
      石原 卓、大西 智子、越智 聡史、秋定 直宏、渡壁 麻依、野上 恵嗣
    • Organizer
      第113回近畿血液学地方会
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Presentation] Generation of the novel humanized mice with hemophilia A2022

    • Author(s)
      Akihisa Oda, Masahiro Kitabatake, Noriko Ouji-sageshima, Toshikazu Takahashi, Toshihiro Ito, Keiji Nogami
    • Organizer
      第51回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] A possible role of DDAVP trial as an auxiliary diagnosis in von Willebrand disease type 1 and type 22022

    • Author(s)
      Ami Morimoto, Kenichi Ogiwara, Naruto Shimonishi, Yuto Nakajima, Shoko Furukawa, Masahiro Takeyama, Masaki Hayakawa, Masanori Matsumoto, Keiji Nogami
    • Organizer
      第84回日本血液学会
    • Data Source
      KAKENHI-PROJECT-17K10128
  • [Presentation] ヒト化免疫血友病マウスの作製2022

    • Author(s)
      小田朗永、 古川晶子、 北畠正大、 王寺典子、 高橋利一、 能村卓慈、 武山雅博、 伊藤利洋、 嶋緑倫、 野上恵嗣
    • Organizer
      第44回血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] A role of P'4 residue on cleavage at Arg372 and Arg1689 in thrombin-catalyzed factor VIII activation2022

    • Author(s)
      Furukawa S, Horiuchi K, Nogami K
    • Organizer
      第84回 日本血液学会
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] A2/C2 domain をブタ第VIII 因子相同配列に組み換えたhybrid ヒト第VIII 因子のインヒビター回避能2022

    • Author(s)
      水町 邦義,中島 由翔,下西 成人,古川 晶子,荻原 建一,武山 雅博,野上 恵嗣
    • Organizer
      第44回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] Escaping ability of human-porcine hybrid factor VIII from anti-human factor VIII inhibitors with A2 or C2 epitope2022

    • Author(s)
      Mizumachi K, Nakajima Y, Shimonishi N Furukawa S, Ogiwara K, Takeyama M, Shima M, Nogami K
    • Organizer
      The 64th American Society of Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] FVIII mutated with Lys1813Ala within the FIXa-binding region enhances coagulation potentials2022

    • Author(s)
      Nakajima Y, Takeyama M, Oda A, Nogami K
    • Organizer
      第84回 日本血液学会
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] Factor VIII K1813A has high affinity for activated factor IX and enhances global coagulation function2022

    • Author(s)
      Nakajima Y, Takeyama M, Oda A, Nogami K
    • Organizer
      International Society of Thrombosis and Hemostasis Congress 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] 血友病Aインヒビター産生細胞の脾臓における動態2021

    • Author(s)
      小田朗永, 中島由翔, 下西成人, 北畠正大, 伊藤利洋, 野上恵嗣
    • Organizer
      第43回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] Anti-FVIII antibody secreting plasma cells persist in the spleen for extended periods of time in mice with hemophilia A after recombinant FVIII treatment.2021

    • Author(s)
      Akihisa Oda, Masahiro Kitabatake, Toshihiro Ito, Keiji Nogami
    • Organizer
      The 50th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-21K07825
  • [Presentation] 凝固線溶波形解析を用いた小児敗血症性DICにおける包括的凝固線溶動態の経時的評価2021

    • Author(s)
      大西 智子、石原 卓、渡壁 麻依、大前 隆志、野上 恵嗣
    • Organizer
      第43回日本血栓止血学会学術集会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Presentation] 血友病治療の新展開2021

    • Author(s)
      野上恵嗣
    • Organizer
      第83回日本血液学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] Current topics on hemophilia and fibrinolysis system2021

    • Author(s)
      Keiji Nogami
    • Organizer
      日本血栓止血学会学術集会SPCシンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] Latest Treatment for Hemophilia A and B in Japan2021

    • Author(s)
      Keiji Nogami
    • Organizer
      ICKSH
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07804
  • [Presentation] FXa生成能を反映する改良凝固1段法の検討2021

    • Author(s)
      松本 智子、酒井 香奈、下村 大樹、野上 恵嗣
    • Organizer
      第43回日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21K09089
  • [Presentation] 小児急性リンパ性白血病の先行治療相で発症した類洞閉塞症候群では凝固能および線溶能が抑制傾向を来す2021

    • Author(s)
      秋定 直宏、石原 卓、越智 聡史、大西 智子、 髙田 晃司、長谷川菜摘、野上 恵嗣
    • Organizer
      第63回日本小児血液・がん学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Presentation] Update on factor (F)VIII structure and function-related hemostatic coagulation and its regulatory mechanism(s)2020

    • Author(s)
      Nogami K
    • Organizer
      82th Annual Meeting of the Japanese Society of Hematology
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Presentation] A new global assay for detection of protein C pathway-associated thrombophilia using thrombomodulin-mediated clot waveform analysis2020

    • Author(s)
      Naoki Hashimoto, Kenichi Ogiwara, Keiji Nogami, Midori Shima
    • Organizer
      International Society on Thrombosis and Hemostasis 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10128
  • [Presentation] 市販後エミシズマブを導入した血友病A小児13例の臨床的検討2019

    • Author(s)
      水町邦義, 荻原建一, 古川晶子, 矢田弘史, 武山雅博, 野上恵嗣, 嶋緑倫
    • Organizer
      第61回日本小児血液・がん学会
    • Data Source
      KAKENHI-PROJECT-17K10125
  • [Presentation] 後天性血友病A患者の治療寛解後にみられる第VIII因子上昇に関する包括的凝固機能解析2019

    • Author(s)
      柴崎史隆. 武山雅博, 野上恵嗣, 笹井香那, 嶋 緑倫
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10125
  • [Presentation] Residues 1680-1684 in the A3 domain of factor VIII contain a novel thrombin-interactive site responsible for proteolysitc clevage at Arg16892019

    • Author(s)
      Nakajima Y, Nogami K, Minami H, Sasai K, Shima M
    • Organizer
      61th American Society of Hematology Annual meeting & Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Quantitative evaluation of fibrin clot strcture formed in the presence of emicizumab using scanning electron microscope2019

    • Author(s)
      Shimonishi N, Nogami K, Ogiwara K, Matsumoto T, Nakazawa F, Noguchi-Sasaki M, Hirata M, Arai N, Shima M
    • Organizer
      International Society on Thrombosis and Hemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] トロンビン・プラスミン生成の低下がみられた肝類洞閉塞症候群(SOS)の1例2019

    • Author(s)
      石原 卓、野上 恵嗣、越智 聡史、水町 邦義、大西 智子、嶋 緑倫
    • Organizer
      第41回日本造血細胞移植学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Presentation] インヒビター保有血友病A患者における活性型第VII因子による凝固改善に必要な第X因子に関する定量的検討2019

    • Author(s)
      矢田 弘史、野上 恵嗣、坪田 夏芽、嶋 緑倫
    • Organizer
      第81回 日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07798
  • [Presentation] Novel measurement of factor VIII by template matching method using weighed center on APTT clot waveform2019

    • Author(s)
      Shimonishi N, Ogiwara K, Nogami K, Oda Y, Kawabe T, Okazaki S, Shima M
    • Organizer
      International Society on Thrombosis and Hemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Additive effect on the global clotting function in moderate/mild hemophilia A by addition of emicizumab, evaluated by clot waveform analysis2019

    • Author(s)
      Nakajima Y, Nogami K, Yada K, Furukawa S, Noguchi M, Hirata M, Shima M
    • Organizer
      International Society on Thrombosis and Hemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Novel Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg16892019

    • Author(s)
      Nakajima Y, Nogami K, Minami H, Sasai K, Shima M
    • Organizer
      the 61st ASH Annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Presentation] 敗血症性DIC症例における包括的凝固/線溶動態の経時的評価2019

    • Author(s)
      大西 智子、野上 恵嗣、伊藤 陽子、大前 隆志、石原 卓、嶋 緑倫
    • Organizer
      第122回日本小児科学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08304
  • [Presentation] Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS)のフィブリン形成能低下とその脆弱性2018

    • Author(s)
      松本 智子、野上 恵嗣、嶋 緑倫
    • Organizer
      第 40 回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] Current and Future Prospects on the Hemostatic Treatment for Hemophilia2018

    • Author(s)
      Keiji Nogami
    • Organizer
      Taiwan Society of Blood and Marrow Tranplantation Annual Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Presentation] Utility of converted factor VIII activity by thrombin generation assay for evaluation of clotting function among hemophilia A carriers2018

    • Author(s)
      Nogami K, Kawamura T, Shima M, Yada K
    • Organizer
      World Federation of Hemophilia 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] A bispecific antibody, Emicizumab (HEMLIBRA), mimicking factor VIII: A novel alternative therapy for patients with hemophilia A with inhibitor2018

    • Author(s)
      Keiji Nogami
    • Organizer
      80th Annual Meeting of the Japanese Society of Hematology
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Presentation] 包括的ダイナミック解析による先天性血友病A患者の凝固線溶動態の特性2018

    • Author(s)
      松本 智子、野上 恵嗣、嶋 緑倫
    • Organizer
      第61回 日本臨床検査医学会近畿支部総会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation2018

    • Author(s)
      Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima
    • Organizer
      60thAmerican Society of Hematology Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 各種APTT試薬を用いた凝固線溶動態評価による新規凝固因子欠乏血漿の分類2018

    • Author(s)
      松本 智子、野上 恵嗣、辻本 藍子、笹井 香那、荻原 建一、竹中 亜利沙、新井 信夫、篠原 翔、田渕 有香、嶋 緑倫
    • Organizer
      第19回 日本検査血液学会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] 4.A Novel Mechanism of Factor VIIa/Tissue Factor (TF)-Catalyzed Activation and Inactivation of B-Domain-Deleted Factor VIII in the Early Initiation Phases of Coagulation2018

    • Author(s)
      Yuto Nakajima, Koji Yada, Keiji Nogami, Midori Shima
    • Organizer
      60th American Society of Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07798
  • [Presentation] Impaired thrombus formation of von Willebrand Disease under high shear flow condition is improved by factor FVIIIa mimetic bispecific antibody(emicizumab)2018

    • Author(s)
      Hiroaki Yaoi, Yasuaki Shida, Keiji Nogami, Takehisa Kitazawa, Midori Shima
    • Organizer
      world federation of hemophilia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10126
  • [Presentation] 1.Bドメイン除去(BDD)第VIII 因子(FVIII)においてFVIIa/TF 惹起FVIII 不活化は遷延される2018

    • Author(s)
      中島 由翔,矢田 弘史,野上 恵嗣,嶋 緑倫
    • Organizer
      第40回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07798
  • [Presentation] A novel hemostatic monitoring with simultaneous clot-fibrinolysis waveform analysis for hemophilia A2018

    • Author(s)
      Aiko Tsujimoto, Keiji Nogami, Tomoko Matsumoto, Kenichi Ogiwara, Takehisa Kitazawa, Midori Shima
    • Organizer
      第80回 日本血液学会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] 第VIII 因子A3 残基1663-1666 にArg1689開裂を制御するトロンビン結合領域が存在する2018

    • Author(s)
      南  博明,野上 恵嗣,笹井 香那,古川 晶子,武山 雅博,嶋  緑倫
    • Organizer
      第40回日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] A novel mechanism of factor VIIa/Tissue Factor (TF)-catalyzed activation and inactivation of B-domain-deleted Factor VIII in the early initiation phases of coagulation2018

    • Author(s)
      Yuito Nakajima, Keiji Nogami, Koji Yada, Midori Shima
    • Organizer
      60th Annual Meeting of the American Society of Hematology
    • Data Source
      KAKENHI-PROJECT-18K07885
  • [Presentation] R2159C 変異FVIII(FVIII-Ise)はC2 ドメインの構造機能変化をきたしている2018

    • Author(s)
      越智 聡史,武山 雅博,野上 恵嗣,嶋  緑倫
    • Organizer
      第40回日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] A new classification of DIC based on the coagulation/fibrinolysis dynamics2018

    • Author(s)
      Tomoko Onishi, Keiji Nogami, Tomoko Matsumoto, Takashi Ishihara, Midori Shima
    • Organizer
      第80回 日本血液学会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] VWD 各病型におけるEmicizumab の高ずり応力下での止血効果2018

    • Author(s)
      矢追博章,志田泰明,野上恵嗣,北沢剛久,嶋緑倫
    • Organizer
      第40回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17K10126
  • [Presentation] 第VIII因子A3ドメイン上の新規第IXa因子結合部位の同定2018

    • Author(s)
      武山 雅博, 野上 恵嗣, 笹井 香那, 嶋  緑倫
    • Organizer
      第80回日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Contribution of Factor VIII A3 Domain Residues 1793-1795 to a Factor IXa-Interactive Site2018

    • Author(s)
      Masahiro Takeyama, Keiji Nogami, Kana Sasai, Midori Shima
    • Organizer
      60thAmerican Society of Hematology Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Mode of enhancement in the global hemostatic potentials with concomitant use of bypassing agents and emicizumab in hemophilia A patients with inhibitor evaluated by ROTEM.2017

    • Author(s)
      Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
    • Organizer
      The XXVI Congress of the ISTH and 63rd Annual Scientific and Standardization Committee (SSC) Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Presentation] FVIIIa Mimicking Bispecific Antibody (emicizumab) Improved Thrombus Formation of Type 2N von Willebrand Disease under Both High and Low Shear Conditions2017

    • Author(s)
      Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa、Kunihiro Hattori, Midori Shima, Keiji Nogami
    • Organizer
      International society of thrombosis and haemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10126
  • [Presentation] Tenase(Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017

    • Author(s)
      矢田 弘史, 野上 恵嗣, 竹中亜利沙, 河村 武志, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Activated FVIII Released From FVIII/VWF Complex Facilitates Thrombus Development Under Flow Condition2017

    • Author(s)
      Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa、Kunihiro Hattori, Midori Shima, Keiji Nogami
    • Organizer
      East Asia hemophilia forum
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10126
  • [Presentation] 第VIII因子A1残基346-349はArg372の開裂を制御する新たなトロンビン結合部位である2017

    • Author(s)
      南博明, 野上恵嗣, 笹井香那, 古川晶子, 武山雅博, 嶋緑倫
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Presentation] 第VIII因子A1残基346-349はArg372の開裂を制御する新たなトロンビン結合部位である2017

    • Author(s)
      南  博明, 野上 恵嗣, 笹井 香那, 古川 晶子, 武山 雅博, 嶋  緑倫
    • Organizer
      第79回 日本血液学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 第IX因子微量存在化におけるemicizumabの凝固能改善効果2017

    • Author(s)
      荻原 建一, 南  博明, 野上 恵嗣, 松本 智子, 北沢 剛久, 服部 有宏, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 抗FIXa/FX-bispecific抗体(Emicizumab)のType2N von Willebrand病での血流下血栓形成能の改善効果2017

    • Author(s)
      矢追博章、志田泰明、野上恵嗣、北沢剛久、服部有宏、嶋 緑倫
    • Organizer
      第39回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10126
  • [Presentation] 血液凝固第VII因子の軌跡と今後の展望2017

    • Author(s)
      野上恵嗣
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Presentation] Clinical and immunological profiles of Mild/Moderate hemophilia A patients with inhibitor2017

    • Author(s)
      Furukawa S, Nogami K, Shima M
    • Organizer
      7th East Asia Hemophilia Forum 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] PT・aPTT混合試薬による凝固波形解析を用いた新たな凝固機能評価法の有用性2017

    • Author(s)
      吉本知史、松本智子、野上恵嗣、嶋緑倫
    • Organizer
      第60回 日本臨床検査医学会近畿支部総会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] 凝固初期相におけるFVIII活性化を介したTF依存性内因系tenase促進機序2017

    • Author(s)
      古川晶子, 野上恵嗣, 荻原建一, 嶋緑倫
    • Organizer
      第39回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Presentation] リン脂質抗体陽性例の凝固波形解析を用いたフィブリン溶解反応における凝固線溶動態の特性2017

    • Author(s)
      松本 智子,, 野上 恵嗣, 笹井 香那, 荻原 建一, 矢田 弘史, 竹中亜利沙, 嶋  緑倫
    • Organizer
      第18回 日本検査血液学会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017

    • Author(s)
      松本 智子, 野上 恵嗣, 笹井 香那, 荻原 建一, 竹中亜利沙, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] 凝固初期相におけるFVIII活性化を介したTF依存性内因系tenase促進機序2017

    • Author(s)
      古川 晶子, 野上 恵嗣, 荻原 建一, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Mode of Enhancement in the Global Hemostatic Potentials with Concomitant Use of Bypassing Agents and Emicizumab in Hemophilia A Patients with Inhibitor Evaluated by ROTEM2017

    • Author(s)
      Yada K, Nogami K, Kitazawa T, Hattori K, Shima M
    • Organizer
      the ISTH 2017 Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Increasing of ternary complex formation by predominant accumulation of factor (F)X accompanied by increase of FIXa contributes to enhancement of clotting function by APCC in combination with emicizumab.2017

    • Author(s)
      Yada K, Nogami K, Matsumoto T, Kitazawa T, Shima M
    • Organizer
      59th ASH Annual meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Presentation] Factor VIIIa mimetic bispecific antibody(Emicizumab) improves thrombus formation of von Willebrand disease under high shear flow conditions2017

    • Author(s)
      Shida Y, Nogami K, Yaoi H, Kitazawa T, Shima M
    • Organizer
      7th East Asia Hemophilia Forum 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 凝固波形解析によるFVIII補因子機能代替抗体emicizumabの包括的凝固機能モニタリング法の確立2017

    • Author(s)
      松本 智子, 野上 恵嗣, 田渕 有香, 添田 哲弘, 新井 信夫, 北沢 剛久, 高岡 秀成, 服部 有宏, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17K10127
  • [Presentation] Factor VIII A1 Residues 346-349 is a Novel Thrombin-binding Site Responsible for cleavage at Arg372 in the Heavy Chain2017

    • Author(s)
      Minami H, Nogami K, Sasai K, Furukawa S, Takeyama M, Shima M
    • Organizer
      the ISTH 2017 Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Anti FIXa/FX Bispecific Antibody (Emicizumab) Enhances Plasma Procoagulant Activity In Hemophilia B in the Presence of Very Low Level of Factor IX2017

    • Author(s)
      Ogiwara K, Minami H, Nogami K, Matsumoto T, Kitazawa T, Hattori K, Shima M
    • Organizer
      the ISTH 2017 Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Factor VIIIa mimetic bispecific antibody (emicizumab) improves thrombus formation of von Willebrand disease under high shear flow condition2017

    • Author(s)
      Yasuaki Shida, Hiroaki Yaoi, Takehisa Kitazawa、Kunihiro Hattori, Midori Shima, Keiji Nogami
    • Organizer
      East Asia hemophilia forum
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10126
  • [Presentation] 凝固波形解析によるFVIII補因子機能代替抗体emicizumabの包括的凝固機能モニタリング法の確立2017

    • Author(s)
      松本 智子, 野上 恵嗣, 田渕 有香, 添田 哲弘, 新井 信夫, 北沢 剛久, 高岡 秀成, 服部 有宏, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] Tenase (Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017

    • Author(s)
      矢田 弘史, 野上 恵嗣, 竹中 亜利沙, 河村 武志, 嶋 緑倫
    • Organizer
      第39回 日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017

    • Author(s)
      松本 智子, 野上 恵嗣, 笹井 香那, 荻原 建一, 竹中亜利沙, 嶋  緑倫
    • Organizer
      第39回 日本血栓止血学会
    • Data Source
      KAKENHI-PROJECT-17H04231
  • [Presentation] 包括的ダイナミック解析による血友病の凝固線溶動態の特性2017

    • Author(s)
      松本智子, 野上恵嗣, 笹井香那, 荻原建一, 竹中亜利沙, 嶋緑倫
    • Organizer
      第39回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Presentation] Tenase(Xase) 反応軸に基づく中等症・軽症血友病Aにおける異常FVIIIの多元的機能解析2017

    • Author(s)
      矢田弘史, 野上恵嗣, 竹中亜利沙, 河村武志, 嶋緑倫
    • Organizer
      第39回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Presentation] Identification of a protein S-interactive site on the factor VIII light chain2016

    • Author(s)
      Shoko Furukawa, Masahiro Takeyama, Keiji Nogami, and Midori Shima
    • Organizer
      The 58th American Society of Hematology
    • Place of Presentation
      サンディエゴ、米国
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] A novel mechanism on thrombin-catalyzed activation of factor VIII molecule during the clot formation2016

    • Author(s)
      Keiji Nogami
    • Organizer
      第38回日本血栓止血学会学術集会 SPCシンポジウム
    • Place of Presentation
      奈良
    • Year and Date
      2016-06-16
    • Data Source
      KAKENHI-PROJECT-15K09663
  • [Presentation] Activated FVIII Released From FVIII/VWF Complex Facilitates Thrombus Development Under Flow Condition2016

    • Author(s)
      Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa, Kunihiro Hattori, Midori Shima, Keiji Nogami
    • Organizer
      American society of hematology
    • Place of Presentation
      San Diego
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] Identification of a protein S-interactive site on the factor VIII light chain2016

    • Author(s)
      Shoko Furukawa, Masahiro Takeyama, Keiji Nogami, and Midori Shima
    • Organizer
      第78回日本血液学会
    • Place of Presentation
      パシフィコ横浜(横浜市西区みなとみらい)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] A New Classification of Mild/Moderate Hemophilia Α Based on a Multi-Dimensional FVIII(a) Functions Evaluated By a Plasma-Based Factor Xa Generation2016

    • Author(s)
      Yada K, Nogami K, Takenaka A, Kawamura T and Shima M
    • Organizer
      58th ASH Annual meeting and Exposition
    • Place of Presentation
      Sandiego, CA, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Presentation] Impact of FVIIIa mimicking antibody, emicizumab, on shear dependent thrombus formation2016

    • Author(s)
      Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa, Kunihiro Hattori, Midori Shima, Keiji Nogami
    • Organizer
      Japanese society of hematology
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] Anti-Factor IXa/FX antibody (ACE910) improves the coagulation function in acquired hemophilia A ex vivo.2015

    • Author(s)
      Masahiro Takeyama, Keiji Nogami, Tomoko Matsumoto, Takehisa Kitazawa, Kunihiro Hattori and Midori Shima
    • Organizer
      The 57th American Society of Hematology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] 血流下血栓形成能は2N型von Willebrand病の臨床的重症度を反映する2015

    • Author(s)
      薮本仁美、矢田弘史、志田泰明、武山雅博、野上恵嗣、細川和也、嶋 緑倫
    • Organizer
      第37回日本血栓止血学会
    • Place of Presentation
      甲府
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] The impact of red blood cells on hemostasis under whole blood flow conditions2015

    • Author(s)
      Yaoi H., Shida Y., Nogami K., Minami H., Matsumoto T, Ogiwara K., Hosokawa K., Shima M
    • Organizer
      25th International Society of Thrombosis and Hemostasis
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-24
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] Arg593Cys変異を伴う軽症血友病Aにおける凝固障害はリン脂質との結合親和性低下に関連する2015

    • Author(s)
      矢田 弘史,野上 恵嗣,神谷 尚,嶋 緑倫
    • Organizer
      第37回日本血栓止血学会学術集会
    • Place of Presentation
      山梨県
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Presentation] 血流下血栓形成能は1型及び2型von Willebrand病に対するデスモプレシン投与効果を反映する2015

    • Author(s)
      矢田弘史、野上恵嗣、志田泰明、武山雅博、細川和也、嶋 緑倫
    • Organizer
      第37回日本血栓止血学会
    • Place of Presentation
      甲府
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] 第VIII因子重鎖A2ドメイン上における第X(a)因子結合部位の同定2015

    • Author(s)
      武山雅博、野上恵嗣、嶋 緑倫
    • Organizer
      第37回日本血栓止血学会
    • Place of Presentation
      甲府
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] 血流下血栓形成過程における第Ⅷ因子代替バイスペシフィック抗体ACE910の作用機序2015

    • Author(s)
      矢追博章、志田泰明、野上恵嗣、南博明、北沢剛久、服部有宏、嶋 緑倫
    • Organizer
      第37回血栓止血学会
    • Place of Presentation
      甲府
    • Year and Date
      2015-05-22
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] A microchip flow-chamber system reflects the clinical phenotype in type 1 von Willebrand disease2015

    • Author(s)
      野上恵嗣、矢田弘史、志田泰明、武山雅博、矢追博章、南 博明、古川晶子、嶋 緑倫
    • Organizer
      第77回日本血液学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-17
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] The usefulness of desmopressin loading test for the diagnosis of severe type 1 von Willebrand disease2015

    • Author(s)
      武山 雅博, 大仲 雅之, 矢田 弘史, 志田 泰明, 松本 智子, 早川 正樹, 松本 雅則, 野上 恵嗣, 嶋 緑倫
    • Organizer
      第57回日本小児血液がん学会
    • Place of Presentation
      山梨
    • Year and Date
      2015-11-29
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] ACE910 improves the coagulation activities in acquired hemophilia A2015

    • Author(s)
      武山雅博,野上恵嗣,矢田弘史,松本智子,北沢剛久,服部有宏,嶋 緑倫
    • Organizer
      第77回日本血液学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-18
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] A novel diagnostic system of acquired coagulation factor inhibitors using comprehensive coagulation assays2015

    • Author(s)
      Matsumoto T, Nogami K, Shima M
    • Organizer
      XXV Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Canada, Toronto
    • Year and Date
      2015-06-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] Longitudinal profile of FVIII-specific IgG subclass during immune rolerance induction therapy2015

    • Author(s)
      Matsumoto T, Nogami K, Shima M
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      石川県、金沢市
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] A Novel Plasma-based Factor Xa Generation Assay Defines Interaction Between FVIIIa and Each Component of Xase Complex in Mild Hemophilia A.2015

    • Author(s)
      Kamiya N, Yada K, Nogami K, and Shima M
    • Organizer
      The International Society on Thrombosis and Haemostasis (ISTH) 2015
    • Place of Presentation
      Tronto, Canada
    • Year and Date
      2015-06-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09664
  • [Presentation] Enhanced Global Hemostatic Potentials with a Bispecific Antibody to Factors IXa and X (ACE910) in the Whole Blood By Rotation Thromboelastometry (ROTEM).2015

    • Author(s)
      Koji Yada, Keiji Nogami, Yasuaki Shida, Masahiro Takeyama, Ryu Kasai, and Midori Shima
    • Organizer
      The 57th American Society of Hematology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] A case of moderate hemophilia A with p.R1800H mutation complicated with juvenile idiopathic arthritis2015

    • Author(s)
      Shida Y., Kondo Y., Ishikawa T., Yada K., Takeyama M., Nogami K., Shima M
    • Organizer
      25th International Society of Thrombosis and Hemostasis
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] Seven cases of acquired hemophilia A2015

    • Author(s)
      Nozomi Okahashi, Ei Hoshino, Atsushi Hasegawa, Haruyuki Tanaka, Itsuto Amano, Hiroshi Kimura, Koji Yada, Yasuaki Shida, Masahiro Takeyama, Keiji Nogami, and Midori Shima
    • Organizer
      第77回日本血液学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-17
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] 軽症血友病B患者の急性大動脈解離に対して、遺伝子組換え第IX因子製剤により人工血管置換術の周術期管理を行った1例2015

    • Author(s)
      武山雅博、志田泰明、矢田弘史、野上恵嗣、嶋 緑倫
    • Organizer
      第1回西日本血友病B研究会
    • Place of Presentation
      大阪
    • Year and Date
      2015-08-01
    • Data Source
      KAKENHI-PROJECT-26461592
  • [Presentation] 微量のTFを添加した改変APTTを用いた血友病Aインヒビターのバイパス止血モニタリング法の確立2015

    • Author(s)
      松本 智子、野上 恵嗣、嶋 緑倫
    • Organizer
      第16回 日本検査血液学会学術集会
    • Place of Presentation
      愛知県、名古屋市
    • Year and Date
      2015-07-11
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] 全血流動システムによって示される赤血球のずり速度依存性止血効果2015

    • Author(s)
      矢追 博章, 志田 泰明, 野上 恵嗣, 松本 智子, 荻原 建一, 細川 和也, 嶋 緑倫
    • Organizer
      第77回日本血液学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-17
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] Application of clot waveform analysis to hemostatic monitoring of bypassing therapy2014

    • Author(s)
      Keiji Nogami
    • Organizer
      60th Annual Scientific and Standardization Committee (SSC)
    • Place of Presentation
      Milwaukee, IL, USA
    • Year and Date
      2014-06-26
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Presentation] The impact of Total-Thrombus Analysis System in the management of VWD with severe anemia2014

    • Author(s)
      Shida Y., Nogami K., Minami H., Yada K., Takeyama M., Matsumoto T., Ogiwara K., Shima M.
    • Organizer
      日本血液学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-01
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] A novel regulatory mechanism of FVIIa/TF associated with FVIII on the initial phase of coagulation2014

    • Author(s)
      野上恵嗣
    • Organizer
      第36回血栓止血学会SPCシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Presentation] 包括的な新規凝固線溶能の評価2014

    • Author(s)
      松本 智子、野上 恵嗣
    • Organizer
      第59回 日本臨床検査医学会近畿支部総会
    • Place of Presentation
      天理医療大学(天理市)
    • Year and Date
      2014-06-21
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] Distinct localization of coagulation factor VIII, von Willebrand factor and factor VIII-mimetic bispecific antibody contributing to thrombus formation under whole blood flow conditions2014

    • Author(s)
      Shida Y., Nogami K., Minami H., Yaoi H., Matsumoto T., Kitazawa T., Hattori K., Shima M
    • Organizer
      American Society of Hematology
    • Place of Presentation
      サンフランシスコ
    • Year and Date
      2014-12-06
    • Data Source
      KAKENHI-PROJECT-26461593
  • [Presentation] 新規凝固機能検査による評価;T-TASとThrombin generation testの基本と臨床2013

    • Author(s)
      松本 智子、荻原 建一、野上 恵嗣、嶋 緑倫
    • Organizer
      第14回 日本検査血液学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] 後天性凝固因子インヒビターの基礎と病態2013

    • Author(s)
      野上恵嗣
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Presentation] 凝固波形解析を用いた血液凝固過程における各凝固因子の役割2013

    • Author(s)
      松本 智子、野上 恵嗣、宮座 静香、矢田 弘史、荻原 建一、南 博明、古川 晶子、嶋 緑倫。
    • Organizer
      第35回 日本血栓止血学会学術集会
    • Place of Presentation
      山形国際ホテル(山形市)
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] Usefulness of thrombin generation assay (TGA) for diagnosis of prolonged aPTT with positive LA.2013

    • Author(s)
      Matsumoto T, Nogami K, Shima M.
    • Organizer
      第75回 日本血液学会
    • Place of Presentation
      ロイトン札幌・さっぽろ芸文館・札幌市教育文化会館(札幌市)
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] Thrombin/Plasmin生成同時測定による新規包括的凝固線溶検査2013

    • Author(s)
      松本 智子、野上 恵嗣、嶋 緑倫
    • Organizer
      第60回 日本臨床検査医学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] 自動凝固分析装置(CS-2000i)を用いた新規凝固波形解析の有用性2013

    • Author(s)
      松本 智子、野上 恵嗣、嶋 緑倫
    • Organizer
      第14回 日本検査血液学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] An Optimal Monitoring On Bypassing Therapy for Hemophilia A Patients with Inhibitor Using aPTT-Based Clot Waveform Analysis with the Presence of Minimal TF2012

    • Author(s)
      Junka Haku, Kenichi Ogiwara, Tomoko Matsumoto, Koji Yada, Midori Shima, Keiji Nogami
    • Organizer
      The 54th annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, GA, USA
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Presentation] A Coagulation Mechanism for the Mild Bleeding Tendency in a Patient with Severe Hemophilia A Possessing an Arg1781His Mutation2012

    • Author(s)
      Koji Yada, Keiji Nogami, Kenichi Ogiwara, Hironao Wakabayashi, Philip J. Fay, Midori Shima
    • Organizer
      The 54th annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, GA, USA
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Presentation] 活性型プロトロンビン複合体製剤による第VIII因子活性化機構2012

    • Author(s)
      矢田弘史、野上恵嗣、荻原建一、松本智子、嶋緑倫
    • Organizer
      第34回日本血栓止血学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591558
  • [Presentation] A novel mechanism of enhancing the haemostatic effect in the combination with recombinant factor VIII and activated prothrombin complex concentrate(APCC) in hemophilia A patients with Inhibitor2011

    • Author(s)
      Yada K, Nogami K, et al
    • Organizer
      第53回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] A novel missense mutation of factor V(factor V Nara : W1920R) manifested thrombosis and demonstrated a positive result of activated protein C resistance assay2011

    • Author(s)
      Shinozawa K, Nogami K, et al
    • Organizer
      第23回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Coagulation velocity and acceleration correlate with clinical phenotype of patients with acquired factor V inhibitors2011

    • Author(s)
      Matsumoto T, Nogami K, et al
    • Organizer
      第23回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] A role and mechanism of plasmin catalyzed factor VIII activation in blood coagulation and fibrinolysis2011

    • Author(s)
      Nogami K
    • Organizer
      第23回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Procoagulant effect of tranexamic acid with minimal urokinase on ex vivo human hemophilia model under blood flow2011

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第23回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] A role and mechanism of plasmin-catalyzed factor VIII activation in blood coagulation and fibrinolysis2011

    • Author(s)
      Nogami K
    • Organizer
      第23回International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-07-25
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Mild clinical phenotype in a severe hemophilia A with Arg1781His substitution associated with increased factor Xa generation2011

    • Author(s)
      Yada K, Nogami K, et al
    • Organizer
      第23回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Evaluation of comprehensive hemostatic function of patients with von Willebrand disease(VWD) under flow using a new microchip flow chamber system2011

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第53回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Mild clinical phenotype in a severe hemophilia A with Arg1781Hissubstitution associated with increased factor Xa generation2011

    • Author(s)
      Yada K, Nogami K (corresponding author), et al
    • Organizer
      第23回International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-07-28
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Perioperative hemostatic management for coarctation of aorta in an early infant with severe haemophilia A2011

    • Author(s)
      Furukawa S, Yoshizawa H, Ogiwara K, Nogami K, et al
    • Organizer
      第23回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Dynamics of plasma factor VIII during the continuous infusion of factor VIII concentrates in twenty patients with hemophilia A2011

    • Author(s)
      Nishiya K, Nogami K, et al
    • Organizer
      第23回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Effects of anti-FVIII inhibitors on the FVIII neutralization therapy for hemophilia A with inhibitor2011

    • Author(s)
      矢田弘史、野上恵嗣(corresponding author), et al
    • Organizer
      第73回日本血液学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-14
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Mechanism of the potent activated protein C resistance of novel factor V mutation with W1920R(FV Nara) relative to R506Q(FV Leiden)2011

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第53回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Procoagulant effect of tranexamic acid with minimal urokinase on ex vivo human hemophilia model under blood flow2011

    • Author(s)
      Ogiwara K, Nogami K (corresponding author), et al
    • Organizer
      第23回International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-07-28
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Pharmacokinetics of continuous infusion therapy of factor VIII concentrates in hemophilia A patients with inhibitors2011

    • Author(s)
      Nishiya K, Tanaka I, Nogami K, et al
    • Organizer
      第53回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] A novel mechanism of enhancing the haemostatic effect in the combination with recombinant factor VIII and activated prothrombin complex concentrate (APCC) in hemophilia A patients with Inhibitor2011

    • Author(s)
      Yada K, Nogami K (corresponding author), et al
    • Organizer
      第53回annual meeting of American Society of Hematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-12-03
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Procoagulant activity of antifibrinolytic agents ; A novel hemostatic mechanism of tranexamic acid and epsilon-aminocaproic acid2010

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第52回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Determination of coagulation functions and inhibitory mechanisms in acquired hemophilia A with type 1 and type 2 inhibitors2010

    • Author(s)
      Matsumoto T, Nogami K (corresponding author), et al.
    • Organizer
      第52回米国血液学会発表
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Tissue factor pathway inhibitor causes unresponsiveness to activated prothrombin complex concentrates for hemophilia A patients with inhibitors2010

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第52回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Determination of coagulation functions and inhibitory mechanisms in acquired hemophilia A with type 1 and type 2 inhibitors2010

    • Author(s)
      Matsumoto T, Nogami K, et al
    • Organizer
      第52回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Tissue factor pathway inhibitor causes unresponsiveness to activated prothrombin complex concentrates for hemophilia A patients with inhibitor2010

    • Author(s)
      Ogiwara K, Nogami K (corresponding author), et al.
    • Organizer
      第52回米国血液学会発表
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Dynamics of plasma factor VIII during the continuous infusion of factor VIII concentrates in patients with hemophilia A2010

    • Author(s)
      Nishiya K, Tanaka I, Nogami K, et al
    • Organizer
      East Asia Haemophilia Forum
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Procoagulant activity of antifibrinolytic agents : A novel hemostatic mechanism of tranexamic and epsilon-aminocaproic acid2010

    • Author(s)
      Ogiwara K, Nogami K (corresponding author), et al.
    • Organizer
      第52回米国血液学会発表
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Mechanisms of factor VIII activation by factor VIIa and its analog NN1731(V158D/E296V/M298Q)2009

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第10回Novo Nordisk Symposium on Hemostasis Management
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Determination for coagulation functions and novel inhibitory mechanisms in acquired hemophilia A with type 2 inhibitors2009

    • Author(s)
      Matsumoto T, Nogami K, et al
    • Organizer
      第51回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Interactions of factor VIII with tissue factor contributes to the acceleration of factor Xa generation in the initiation phase of blood coagulation2009

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第51回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Procoagulant effect of plasmin dependent on factor V and factor VIII during the blood coagulation process2009

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      第22回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Deep venous thromboembolism in a patient of factor V deficiency2009

    • Author(s)
      Nishiya K, Nogami K, et al
    • Organizer
      第22回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Effects of anti-FVIII inhibitors on factor VIIa tissue factor-catalyzed activation and inactivation of factor VIII2009

    • Author(s)
      Yada K, Nogami K, et al
    • Organizer
      第51回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Interactions of factor VIII with tissue factor contributes to the acceleration of factor Xa generation in the initiation phase of blood coagulation2009

    • Author(s)
      Ogiwara K, Nogami K(corresponding author), et al.
    • Organizer
      第51回米国血液学会発表
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-08
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Effects of anti-FVIII inhibitors on factor VIIa/tissue factor-catalyzed activation and inactivation of factor VIII2009

    • Author(s)
      Yada K, Nogami K(corresponding author), et al.
    • Organizer
      第51回米国血液学会発表
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-08
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Elevation of coagulant activity by plasmin via factor VIII on the blood coagulation2009

    • Author(s)
      Ogiwara K, Nogami K(corresponding author), et al.
    • Organizer
      第22回国際血栓止血学会
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2009-07-15
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Mechanisms of human neutrophil elastase-catalyzed inactivation of the factor VIII(a)2009

    • Author(s)
      Nishiya K, Nogami K, et al
    • Organizer
      第51回米国血液学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Mechanisms of human neutrophil elastase-catalyzed inactivation of the factor VIII(a)2009

    • Author(s)
      Nishiya K, Nogami K(corresponding author), et al.
    • Organizer
      第51回米国血液学会発表
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-12-07
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] Anti-A2 monoclonal antibody enhancing thrombin and factor Xa-catalyzed factor VIII activity2009

    • Author(s)
      Takeyama M, Nogami K, et al
    • Organizer
      第22回国際血栓止血学会
    • Data Source
      KAKENHI-PROJECT-21591370
  • [Presentation] 活性型第VIII因子軽鎖C2ドメイン上における活性型第IX因子結合部位の同定2008

    • Author(s)
      添田哲弘, 野上恵嗣, 他
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2008-10-11
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Mechanisms of factor VIII activation by recombinant factor VIIa analog through tissue factor-independent manner2008

    • Author(s)
      Ogiwara K, Nogami K, et al
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-06
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Tissue factor-dependent activation of factor VIII by factor VIIa in the early phase of bloodcoagulation2008

    • Author(s)
      Soeda T, Nogami K, et.al.
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2008-12-06
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 「血友病の分子病態の進歩と臨床応用の展望」 FVIIa、FVIIIを介する止血メカニズムの新たな展開2008

    • Author(s)
      荻原建一、野上恵嗣、他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-11-20
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 活性型第VII因子アナログによる組織因子非依存性の第VIII因子制御機構2008

    • Author(s)
      荻原建一, 野上恵嗣, 他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2008-11-21
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 6-aminohexanoic acid(6-AHA)の凝固亢進作用2008

    • Author(s)
      荻原建一、野上恵嗣、他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-11-20
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Identification of a factor IXa-interactive site within the C2 domain of factor VIIIa and a crucial role of these associations for the process of clot formation2008

    • Author(s)
      Soeda T, Nogami K, et.al.
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2008-12-06
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Identification of a factor IXa-interactive site within the C2 domain of factor VIIIa and a crucial role of these associations for the process of clot formation2008

    • Author(s)
      Soeda T, Nogami K, et al
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-06
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 6-aminohexanoic acid (6-AHA)の凝固亢進作用2008

    • Author(s)
      荻原建一, 野上恵嗣, 他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2008-11-22
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Plasminogen/Plasminはlysine-binding site依存性に活性型第V因子と結合する2008

    • Author(s)
      西屋克巳, 野上恵嗣, 他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2008-11-21
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Lysine-binding site-dependent interaction with plasmin and factor Va responsible for plasmin-catalyzed factor Va inactivation2008

    • Author(s)
      Nishiya K, Nogami K, et al
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-07
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 活性型第VII因子/組織因子による第VIII因子制御機構2008

    • Author(s)
      添田哲弘, 野上恵嗣, 他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2008-11-21
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 活性型第IX因子と第VIII因子軽鎖C2ドメイン問特異的阻害ペプチドの抗血栓作用2008

    • Author(s)
      添田哲弘, 野上恵嗣, 他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2008-11-21
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 血友病A各種病型の第VIII因子活性とトロンビン生成能2008

    • Author(s)
      松本智子, 野上恵嗣, 他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2008-11-21
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 「血友病の分子病態の進歩と臨床応用の展望」 FVIIa、FVIIIを介する止血メカニズムの新たな展開2008

    • Author(s)
      荻原建一, 野上恵嗣, 他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2008-11-20
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Tissue factor-dependent activation of factor VIII by factor VIIa in the early phase of blood coagulation2008

    • Author(s)
      Soeda T, Nogami K, et al
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-12-06
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 凝固因子と線溶因子の新たな接点-Plasminogen/Plasminによる第VIII因子制御機構をモデルとして2007

    • Author(s)
      西屋 克巳、野上 恵嗣, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 第VIII因子軽鎖C2ドメインは活性型第IX因子Glaドメインに結合する2007

    • Author(s)
      添田 哲弘、野上 恵嗣, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007

    • Author(s)
      Takeyama M, Nogami K, et. al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 凝固初期相におけるプラスミンの向凝固作用2007

    • Author(s)
      荻原 建一、野上 恵嗣, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Role of direct interaction between factor VIII C2 domain and factor IXa Gla domain in facctor Xase complex2007

    • Author(s)
      Soeda T, Nogami K, et. al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 第VIII因子軽鎖C2は活性型第IX因子Glaドメインに結合する2007

    • Author(s)
      添田 哲弘、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 血友病Aインヒビターの免疫生化学的側面2007

    • Author(s)
      野上 恵嗣
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007

    • Author(s)
      Takeyama M, Nogami K, Shima M, et. al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Localization of fastor VIII interastive site within plasmin/plasminogen which is responseible for plasmin-catalyzed activation/inactivation of factor VIII2007

    • Author(s)
      Nishiya K, Nogami K, Shima M, et. al
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-11-09
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Localization of factor VIII-interactive site within plasmin/plasminogen which is responsible for plasmin-catalyzed activation/inactivation of factor VIII2007

    • Author(s)
      Nishiya K, Nogami K, et. al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-09
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Localization of factor VIII-interactive site within plasmin/plasminogen which is responsible for plasmin-catalyzed activation and inactivation of factor VIII2007

    • Author(s)
      Nishiya K, Nogami K, et.al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, GA
    • Year and Date
      2007-12-09
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 第VIII因子A2ドメイン上のプロテインS結合部位の同定2007

    • Author(s)
      武山 雅博、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 凝固因子と線溶因子の新たな接点-Plasminogen/Plasminによる第VIII因子制御機構をモデルとして.2007

    • Author(s)
      西屋 克己、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 第VIII因子A2ドメイン上のプロテインS結合部位の同定2007

    • Author(s)
      武山 雅博、野上 恵嗣, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 後天性血友病type2患者のトロンビン生成能低下の作用機序2007

    • Author(s)
      松本 智子、 野上 恵嗣、 嶋 緑倫, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      賢島
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007

    • Author(s)
      Takeyama M, Nogami K, et.al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, GA
    • Year and Date
      2007-12-09
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 凝固初期相におけるプラスミンの向凝固作用2007

    • Author(s)
      荻原建一、野上恵嗣他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島市
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 血友病Aインヒビターの免疫生化学的側面2007

    • Author(s)
      野上恵嗣
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島市
    • Year and Date
      2007-11-15
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] インヒビター陽性血友病Aに対する補充療法における凝血学的効果の多様性2007

    • Author(s)
      矢田 弘史、吉田 幸一、野上 恵嗣, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] Role of direct interaction between factor C2 and factor IXa Gla domain in factor Xase complex.2007

    • Author(s)
      Soeda T, Nogami K, Shima M, et. al
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta
    • Year and Date
      2007-12-10
    • Data Source
      KAKENHI-PROJECT-17591110
  • [Presentation] 後天性血友病A type2患者のトロンビン生成能低下の作用機序2007

    • Author(s)
      松本 智子、野上 恵嗣, 他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島
    • Year and Date
      2007-11-16
    • Data Source
      KAKENHI-PROJECT-19591264
  • [Presentation] 血友病Aと抗リン脂質抗体症候群の診断における凝固波形解析の有用性

    • Author(s)
      松本 智子、野上 恵嗣、嶋 緑倫
    • Organizer
      第15回 日本検査血液学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2014-07-20 – 2014-07-21
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] 第V因子変異R506Q(FVLeiden)より強いAPCレジスタンスを示したFV変異W1920R(FVNara)

    • Author(s)
      荻原建一,野上恵嗣,篠澤圭子,松本智子,古川晶子,西屋克己,矢田弘史,福武勝幸,嶋緑倫
    • Organizer
      第34回日本血栓止血学会
    • Place of Presentation
      ハイアットリージェンシー東京
    • Data Source
      KAKENHI-PROJECT-24591560
  • [Presentation] Distinction of APC reactivity for acquired coagulation inhibitor can predict the clinical phenotypes

    • Author(s)
      Tomoko M, Keiji N, Midori S
    • Organizer
      第76回 日本血液学会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-25461605
  • [Presentation] Factor VIII A2 domain contains a binding site for factor X

    • Author(s)
      Masahiro Takeyama, Keiji Nogami, Tomoko Matsumoto, Midori Shima
    • Organizer
      The 56th American Society of Hematology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-12-05 – 2014-12-09
    • Data Source
      KAKENHI-PROJECT-26461592
  • 1.  Yada Koji (30635785)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 27 results
  • 2.  Matsumoto Tomoko (80642678)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 48 results
  • 3.  TAKEYAMA MASAHIRO (30572010)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 24 results
  • 4.  SHIMA Midori (30162663)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 54 results
  • 5.  Ogiwara Kenichi (50623500)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 6.  shida yasuaki (10721566)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 23 results
  • 7.  Oda Akihisa (80547703)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 8.  北畠 正大 (60457588)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 9.  SUGIMOTO Mitsuhiko (80192128)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SAKURAI Yoshihiko (80347559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Takashi Ishihara (00533712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 12.  朴 永東 (10285364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  中 宏之 (40281761)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  大西 智子 (60645589)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 15.  下村 大樹 (70723302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  中島 由翔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  松下 正
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  末延 聡一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  辻井 信之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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