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OKAWARA TOMOMI  大河原 知水

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大河原 知水  オオカワラ トモミ

OOKAWARA Tomomi  大河原 知水

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Researcher Number 50330452
Other IDs
Affiliation (Current) 2025: 兵庫医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2023: 兵庫医科大学, 薬学部, 教授
2011 – 2012: 兵庫医療大学, 薬学部, 教授
2008 – 2010: Hyogo University of Health Sciences, 薬学部, 准教授
2001 – 2007: 兵庫医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Hygiene / Hygiene
Except Principal Investigator
Pathological medical chemistry / Nerve anatomy/Neuropathology / Basic Section 59040:Nutrition science and health science-related / General medical chemistry / Pathological medical chemistry
Keywords
Principal Investigator
スーパーオキシドジスムターゼ / 活性酸素 / 動脈硬化 / 酸化ストレス / mutation / DNA damae / nuclear localization signal / 3T3-LI cell / extracellular superoxide dismutase / superoixde dismutase … More / reactive oxygen species / 突然変異 / DNA傷害 / 核移行シグナル / 3T3-L1 / 細胞外型SOD / N-結合型糖鎖 / メタボリック症候群 / 肥満 / 脂肪前駆細胞 / 高血圧症 / N結合型糖鎖修飾 / 細胞外型スーパーオキシドジスムターゼ / 予防医学 / 血管平滑筋 / 一酸化窒素 / 生活習慣病 / EC-SOD … More
Except Principal Investigator
Cu / HB-EGF / Zn-SOD / スーパーオキシドジスムターゼ / 酸化ストレス / 活性酸素 / reactive oxygen species / 動脈硬化 / 鉄 / 酸化 / ALS / 筋萎縮性側索硬化症 / 抗体 / 鉄欠乏 / 細胞質型アコニターゼ / 老化 / 鉄代謝 / 細胞質型のアコニターゼ / Cu, Zn-SOD / cleavage of oligosaccharides / LEC rat / sugar chain / SOD / プロテオグリカン / ヒアルロン酸 / 銅イオン / トランスフェリン / グリコサミノグリカン / 糖鎖 / Cys111 / Cu,Zn-SOD / LECラット / 家族性筋萎縮性側策硬化症 / 活性酸素種 / conformational change / oxidation / monoclonal antibody / superoxide dismutase / amyotrophic lateral sclerosis / モノクローナル抗体 / 銅代謝 / 脳神経疾患 / arteriosclerosis / oxidative stress / EC-SOD / superoxside dismutase / ROS / DNA傷害 / 核移行シグナル / 突然変異 / N型糖鎖 / FALS / 細胞外型SOD / smooth muscle cells / arterioselerosis / Nitric oxide / HP-EGF / アポトーシス / JNK / 血管平滑筋 / 過酸化物 / 一酸化窒素 / Zn-SODノックアウトマウス / スーパーオキドジスムターゼ / 過酸化脂質 / ヒドロキシノネナール / Cu/Zn-SODノックアウトマウス / グルタチオンSトランスフェラーゼ / 腎臓 / SOD1ノックアウトマウス / SOD1 / チャージアイソマー / 構造変化 / MALDI-TOF-MS / 酸化的翻訳後修飾 / 筋萎縮性側索硬化症(ALS) Less
  • Research Projects

    (10 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (13 People)
  •  鉄欠乏は老化を促進するのか?:鉄含有酵素ACO1による生体防御機構の解明

    • Principal Investigator
      吉原 大作
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Hyogo Medical University
  •  Obesity and oxidative stress: involvement of SOD in the physiology of metabolic syndrome and atherosclerosisPrincipal Investigator

    • Principal Investigator
      OOKAWARA Tomomi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Hyogo University of Health Sciences
  •  The compensatory mechanism against oxidative stress in kidney dysfunction

    • Principal Investigator
      SUZUKI Keiichiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hyogo College of Medicine
  •  The role of oxidized SOD1 on ALS using the new antibody against oxidized SOD1 (anti-C111ox-SOD1)

    • Principal Investigator
      FUJIWARA Noriko
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Hyogo College of Medicine
  •  Anti-oxidative effect of EC-SOD and prevention of atherosclerosis in lifestyle-related diseases.Principal Investigator

    • Principal Investigator
      OOKAWARA Tomomi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Hyogo University of Health Sciences
      Hyogo College of Medicine
  •  Nuclear translocation of antioxidant enzymes and ROS metabolism

    • Principal Investigator
      SUZUKI Keiichiro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hyogo College of Medicine
  •  Conformational change in FALS-linked mutant Cu/Zn-SOD analyzed by monoclonal antibodies

    • Principal Investigator
      FUJIWARA Noriko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Hyogo College of Medicine
  •  Nuclear translocation of antioxidant enzymes and ROS metabolism

    • Principal Investigator
      SUZUKI Keiichirou
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Hyogo College of Medicine
  •  A possible mechanism of mutagenesis : oxidative stress and nuclear translocation of superoxide dismutase.Principal Investigator

    • Principal Investigator
      OOKAWARA Tomomi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hygiene
    • Research Institution
      Hyogo College of Medicine
  •  Mechanism of arteriosclerosis evoked by production and processing of HB-EGF induced by nitric oxide

    • Principal Investigator
      SUZUKI Keiichiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hyogo College of Medicine

All 2011 2009 2008 2007 2004 2003 Other

All Journal Article Presentation Book

  • [Book] ストレスの医学(吉川敏一監修)(CHAPTER 3, 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系酸化)2008

    • Author(s)
      鈴木敬一郎、藤原範子、大河原知水
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-20590320
  • [Book] 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系. 酸化ストレスの医学, (吉川敏一 監修)2008

    • Author(s)
      鈴木敬一郎, 藤原範子, 大河原知水
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-19590605
  • [Book] CHAPTER 3, 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系、酸化ストレスの医学(吉川敏一監修)

    • Author(s)
      鈴木敬一郎、藤原範子、大河原知水
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-19500313
  • [Journal Article] N-Glycosylation profiling of recombinant mouse extracellular superoxide dismutase produced in Chinese hamster ovary cells2011

    • Author(s)
      Korekane H
    • Journal Title

      Glycoconj J

      Volume: 28 Issue: 3-4 Pages: 183-196

    • DOI

      10.1007/s10719-011-9333-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-22590563, KAKENHI-PROJECT-22650101, KAKENHI-PROJECT-23501303
  • [Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages2011

    • Author(s)
      Kizaki, T., Maegawa, T., Sakurai, T., Ogasawara, J., Ookawara, T., Oh-ishi, S., Izawa, T., Haga, S. & Ohno, H.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 413 Issue: 3 Pages: 454-459

    • DOI

      10.1016/j.bbrc.2011.08.117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300237, KAKENHI-PROJECT-22590563, KAKENHI-PROJECT-22650154, KAKENHI-PROJECT-22700655, KAKENHI-PROJECT-23590752, KAKENHI-PROJECT-23700778
  • [Journal Article] 酸化ストレスと健康、2009

    • Author(s)
      江口裕伸、藤原範子、大河原知水、鈴木敬一郎、谷口直之
    • Journal Title

      生物資料分析 Vol.32, No.4

      Pages: 247-256

    • NAID

      40019884015

    • Data Source
      KAKENHI-PROJECT-20590320
  • [Journal Article] 酸化ストレスと健康2009

    • Author(s)
      江口裕伸、藤原範子、大河原知水、鈴木敬一郎、谷口直之
    • Journal Title

      生物資料分析 Vol.32,No.4

      Pages: 247-256

    • NAID

      40019884015

    • Data Source
      KAKENHI-PROJECT-19500313
  • [Journal Article] Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice2009

    • Author(s)
      Yoshihara D., Fujiwara N., Ookawara T., Kato S., Sakiyama H., Yokoe S., Eguchi H., Suzuki K
    • Journal Title

      Free Radic. Biol. Med 47

      Pages: 559-567

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500313
  • [Journal Article] Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice2009

    • Author(s)
      Yoshihara D., Fujiwara N., Ookawara T., Kato S., Sakiyama H., Yokoe S., Eguchi H., Suzuki K.
    • Journal Title

      Free Radic. Biol. Med. 47

      Pages: 559-567

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590320
  • [Journal Article] 新時代の糖尿病学(2)病因・診断・治療研究の進歩 スーパーオキシドジスムターゼ2008

    • Author(s)
      大野秀樹, 木崎節子, 櫻井拓也, 大河原知水, 鈴木敬一郎
    • Journal Title

      日本臨牀 66(増刊4)

      Pages: 351-354

    • Data Source
      KAKENHI-PROJECT-19590605
  • [Journal Article] Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta.2008

    • Author(s)
      Hitomi Y, Watanabe S, Kizaki T, Sakurai T, Takemasa T, Haga S, Ookawara T, Suzuki K, Ohno H.
    • Journal Title

      Redox Rep. 13

      Pages: 213-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590605
  • [Journal Article] Oxidative modification to cysteine sulfonic Acid of cys111 in human copper-zinc superoxide dismutase2007

    • Author(s)
      Fujiwara N., Nakano M, Kato S, Yoshihara D, Ookawara T, Eguchi H, Taniguchi N, Suzuki K
    • Journal Title

      J. Biol. Chem 282

      Pages: 35933-35944

    • NAID

      120006782320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500313
  • [Journal Article] Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase.2007

    • Author(s)
      Yoshihara D, Ookawara T, Eguchi H, Taniguchi N, Suzuki K.
    • Journal Title

      J. Biol Chem. 282

      Pages: 35933-44

    • NAID

      120006782320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590605
  • [Journal Article] Down-regulation of beta2-adrenergic receptor expression by exercise training increase IL-12 production by macrophages following LPS stimulation.2004

    • Author(s)
      Ookawara, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 322

      Pages: 379-384

    • Data Source
      KAKENHI-PROJECT-15590258
  • [Journal Article] An inter-subunit disulfide bond affects affinity of human lung extracellular superoxide dismutase to heparin.2003

    • Author(s)
      Ookawara, T.
    • Journal Title

      Free Radic. Res. 37

      Pages: 823-827

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590258
  • [Journal Article] Effects of oxidative stress on the nuclear translocation of extracellular superoxide dismutase.2003

    • Author(s)
      Ookawara, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 303

      Pages: 914-919

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590258
  • [Journal Article] Effects of oxidative stress on the nuclear translocation of extracellular superoxide dismutase.2003

    • Author(s)
      Ookawara, T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 303

      Pages: 914-919

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590258
  • [Journal Article] Effects of endurance training on three Superoxide dismutase isoenzymes in human plasma.2003

    • Author(s)
      Ookawara, T.
    • Journal Title

      Free Radic. Res. 372

      Pages: 713-719

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590258
  • [Journal Article] An inter-subunit disulfide bond affects affinity of human lung extracellular superoxide dismutase to heparin.2003

    • Author(s)
      Ookawara, T.
    • Journal Title

      Free Radic.Res. 37

      Pages: 823-827

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590258
  • [Journal Article] Effects of endurance training on three Superoxide dismutase isoenzymes in human plasma.2003

    • Author(s)
      Ookawara, T.
    • Journal Title

      Free Radic.Res. 372

      Pages: 713-719

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590258
  • [Journal Article] Extracellular superoxide dismutase following cerebral ischemia in mice.2003

    • Author(s)
      Ookawara, T.
    • Journal Title

      Acta Neurochir Suppl. 86

      Pages: 83-85

    • Data Source
      KAKENHI-PROJECT-15590258
  • [Presentation] GSTA4-4 as a biomarker of oxidative stress in renal tubular cells2008

    • Author(s)
      Yoshihara D., Fujiwara N., Ookawara T., Yokoe S., Suzuki K.
    • Organizer
      BOSHD2008 Biomarkers of Oxidative Stress in Health and Diseases
    • Place of Presentation
      Osaka
    • Data Source
      KAKENHI-PROJECT-20590320
  • [Presentation] Cu/Zn-SODノックアウトマウスにおけるGSTA4の生理的意義2008

    • Author(s)
      吉原大作、藤原範子、大河原知水、横江俊一、崎山晴彦、鈴木敬一郎
    • Organizer
      第61回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-20590320
  • [Presentation] EC-SODの細胞内分布に対する酸化ストレス、一酸化窒素の影響2008

    • Author(s)
      大河原知水, ほか
    • Organizer
      第8回日本NO学会学術集会
    • Place of Presentation
      仙台市国際センター
    • Year and Date
      2008-05-10
    • Data Source
      KAKENHI-PROJECT-19590605
  • [Presentation] SOD1ノックアウトマウスにおけるGSTA4の誘導と生理的意義2008

    • Author(s)
      吉原大作、藤原範子、大河原知水、崎山晴彦、横江俊一、江口裕伸、鈴木敬一郎
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会(BMB2008)(p14)
    • Place of Presentation
      神戸(Late-Breaking Abstracts)
    • Data Source
      KAKENHI-PROJECT-20590320
  • [Presentation] Cys111 in human copper-zinc-superoxide dismutase is a primary target for peroxidation to cysteine sulfonic acid2008

    • Author(s)
      Fujiwara N., Nakano M., Yoshihara D., Ookawara T., Eguchi H., Taniguchi N., Suzuki K.
    • Organizer
      The Gordon Research conference on Thiol-based Redox Regulation and Signaling
    • Place of Presentation
      Lucca, Italy
    • Data Source
      KAKENHI-PROJECT-20590320
  • [Presentation] ヒトCu/Zn-スーパーオキシドジスムターゼ(SOD1)のCys111の酸化と酸化型SOD1特異抗体の作製2008

    • Author(s)
      藤原範子、中の三弥子、大河原知水、吉原大作、横江俊一、加藤信介、谷口直之、鈴木敬一郎
    • Organizer
      第61回日本酸化ストレス学会学術集会(p66)
    • Place of Presentation
      京都(抄録)
    • Data Source
      KAKENHI-PROJECT-20590320
  • [Presentation] ヒトCu/Zn-スーパーオキシドジスムターゼ(SOD1)のCys111の酸化と酸化型SOD1特異抗体の作製2008

    • Author(s)
      藤原範子、中の三弥子、大河原知水、吉原大作、横江俊一、加藤信介、谷口直之、鈴木敬一郎
    • Organizer
      第61回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19500313
  • [Presentation] EC-SODの細胞内分布に対する酸化ストレス、一酸化窒素の影響2008

    • Author(s)
      大河原知水
    • Organizer
      第8回日本NO学会学術集会
    • Place of Presentation
      仙台市
    • Year and Date
      2008-05-10
    • Data Source
      KAKENHI-PROJECT-19590605
  • [Presentation] Cys111 in human copper-zinc-superoxide dismutase is a primary target for peroxidation to cysteine sulfonic acid2008

    • Author(s)
      Fujiwara N., Nakano M., Yoshihara D., Ookawara T., Eguchi H., Taniguchi N., Suzuki K
    • Organizer
      The Gordon Research conference on Thiol-based Redox Regulation and Signaling
    • Place of Presentation
      Lucca, Italy
    • Data Source
      KAKENHI-PROJECT-19500313
  • [Presentation] Effects of copper metabolism on behavioral functions and brain monoamine contents in Wistar and Wilson's disease model rats2007

    • Author(s)
      Fujiwara, N., Iso, H., Kitanaka, N., Kitanaka, J., Yoshihara, D., Ookawara, T., Suzuki, K
    • Organizer
      ISTERH2007
    • Place of Presentation
      Crete, Greece
    • Data Source
      KAKENHI-PROJECT-19500313
  • [Presentation] Role of Cys111 in an oxidative damage of human Cu/Zn-superoxide dismutase2007

    • Author(s)
      Fujiwara, N., Nakano, M., Yoshihara, D., Ookawara, T., Eguchi, H., Taniguchi, N., Suzuki, K
    • Organizer
      第30回日本神経科学大会、第50回日本神経化学会大会、第17回日本神経回路学会大会、合同大会(Neuro 2007)
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19500313
  • [Presentation] マウスEC-SODの翻訳調節機構2007

    • Author(s)
      大河原 知水, ほか
    • Organizer
      第80回日本生化学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-12-14
    • Data Source
      KAKENHI-PROJECT-19590605
  • [Presentation] Role of Cys111 in an oxidative damage and generation of charge isomers of human Cu/Zn-superoxide dismutase2007

    • Author(s)
      hihara, D., Ookawara, T., Taniguchi, N., Suzuki, K
    • Organizer
      第30回日本分子生物学会大会、第80回日本生化学会大会、合同大会(BMB2007)
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19500313
  • 1.  SUZUKI Keiichiro (70221322)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 21 results
  • 2.  FUJIWARA Noriko (10368532)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 17 results
  • 3.  EGUCHI Hironobu (60351798)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 9 results
  • 4.  YOKOE Syunichi (40454756)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 5.  SAKIYAMA Haruhiko (30508958)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 6.  KOREKANE Atsuko (80461169)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YOSHIHARA Daisaku (00567266)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 8.  YAMAGUCHI Yukihiro (60330453)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KUROTSU Tositsugu (20098528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  大野 秀樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  木崎 節子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  櫻井 拓也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  小笠原 準悦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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