Suzuki Toru 鈴木亨

… Alternative Names

Researcher Number	50334280
Other IDs
Affiliation (Current)	2021: 東京大学, 医科学研究所, 助教
Affiliation (based on the past Project Information) *help	2018 – 2020: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2009 – 2010: The University of Tokyo, 医科学研究所, 助教 2007: 東京大学, 医科学研究所, 助教 2002 – 2005: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Cell biology / Biological Sciences / Genetics/Genome dynamics / Basic Section 49030:Experimental pathology-related Except Principal Investigator Neurochemistry/Neuropharmacology / Biological Sciences
Keywords	Principal Investigator Tob / DNA損傷応答 / DNA損傷 / 細胞周期 / リン酸化 / 増殖抑制 / 遺伝子発現誘導 / 間葉系細胞分化 / 発癌モデルマウス / 細胞死 … More Except Principal Investigator シグナル伝達 / 癌 / RNAi / 糖鎖 / マイクロアレイ / 生理活性 / 細胞増殖 / 癌抑制遺伝子 / 蛋白質リン酸化 / 転写因子複合体 / 遺伝子マウス改変 / 蛋白質 / 転写複合体 / プロテオーム / 蛋白質リン酸化反応 / 細胞周期 / 肺癌細胞株 / 遺伝子欠損マウス / Tob / Caf1 / CCR4 / NOT / LATS / Ndr / LATSファミリー / G1制御 / Tobファミリー蛋白質 / アダプター分子 / G2-Mチェックポイント / G1期制御 / cancer / cell growth / signal transduction- / tumor suppressor gene / protein phosphorylation / transcription factor complex / gene manipulated mice Less

細胞間相互作用を介した肝再生機構の解明と再生肝細胞の起源の同定Principal Investigator
- Principal Investigator
  
  鈴木亨
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Institute of Physical and Chemical Research
Analysis of the effects of cell growth and cell death regulation on tumor development using tumor mice modelsPrincipal Investigator
- Principal Investigator
  
  SUZUKI Toru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  The University of Tokyo
糖転移酵素遺伝子アレイの確立と応用
- Principal Investigator
  
  藤本一朗
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
細胞増殖抑制因子Tobの増殖・分化における役割とその発現制御機構の解析Principal Investigator
- Principal Investigator
  
  鈴木亨
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
癌抑制遺伝子産物Tobによる細胞増殖制御機構と細胞の癌化・老化機構の解析Principal Investigator
- Principal Investigator
  
  鈴木亨
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokyo
Mechanisms of cell growth and malignant transformation regulated by protein phosphorylation and dephosphorylation
- Principal Investigator
  
  YAMAMOTO Tadashi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2011 2010 2002 2001 2000

All Journal Article Presentation

[Journal Article] ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism.2020
- Author(s)
  Otsuka Hiroshi、Fukao Akira、Tomohiro Takumi、Adachi Shungo、Suzuki Toru、Takahashi Akinori、Funakami Yoshinori、Natsume Toru、Yamamoto Tadashi、Duncan Kent E.、Fujiwara Toshinobu
- Journal Title
  
  Biochimie
  
  Volume: 174 Pages: 49-56
- DOI
  10.1016/j.biochi.2020.04.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-19K07929
[Journal Article] Insufficient liver maturation affects murine early postnatal hair cycle2020
- Author(s)
  Suzuki T., Kikuguchi C, Nishijima S., and Yamamoto T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 521 Pages: 172-177
- DOI
  10.1016/j.bbrc.2019.10.099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07079
[Journal Article] Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.2020
- Author(s)
  Mostafa Dina、Takahashi Akinori、Yanagiya Akiko、Yamaguchi Tomokazu、Abe Takaya、Kureha Taku、Kuba Keiji、Kanegae Yumi、Furuta Yasuhide、Yamamoto Tadashi、Suzuki Toru
- Journal Title
  
  RNA Biol
  
  Volume: 17 Pages: 403-416
- DOI
  10.1080/15476286.2019.1709747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-18K15038, KAKENHI-PROJECT-20K08195
[Journal Article] Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation2020
- Author(s)
  Mostafa D, Yanagiya A, Georgiadou E, Wu Y, Stylianides T, Rutter GA, Suzuki T*, Yamamoto T*
- Journal Title
  
  Communications Biology
  
  Volume: 476 Pages: 1-16
- DOI
  10.1038/s42003-020-01201-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-18H02425
[Journal Article] The CCR4?NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression2020
- Author(s)
  Ito-Kureha Taku、Miyao Takahisa、Nishijima Saori、Suzuki Toru、Koizumi Shin-ichi、Villar-Briones Alejandro、Takahashi Akinori、Akiyama Nobuko、Morita Masahiro、Naguro Isao、Ishikawa Hiroki、Ichijo Hidenori、Akiyama Taishin、Yamamoto Tadashi
- Journal Title
  
  Nature Communications
  
  Volume: 11 Pages: 6169-6169
- DOI
  10.1038/s41467-020-19975-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-20K07332, KAKENHI-PUBLICLY-19H04821, KAKENHI-PROJECT-18H03995, KAKENHI-PROJECT-17K08622, KAKENHI-PROJECT-18K07237, KAKENHI-PROJECT-19K22547
[Journal Article] Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development2020
- Author(s)
  Suzuki Toru、Adachi Shungo、Kikuguchi Chisato、Shibata Shinsuke、Nishijima Saori、Kawamoto Yurie、Iizuka Yusuke、Koseki Haruhiko、Okano Hideyuki、Natsume Tohru、Yamamoto Tadashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Pages: 9319-9319
- DOI
  10.3390/ijms21239319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-18K14840
[Journal Article] The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation.2020
- Author(s)
  Takahashi Akinori、Suzuki Toru、Soeda Shou、Takaoka Shohei、Kobori Shungo、Yamaguchi Tomokazu、Mohamed Haytham Mohamed Aly、Yanagiya Akiko、Abe Takaya、Shigeta Mayo、Furuta Yasuhide、Kuba Keiji、Yamamoto Tadashi
- Journal Title
  
  Life science alliance.
  
  Volume: 3 Pages: 1-19
- DOI
  10.26508/lsa.201900494
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-20K21566, KAKENHI-PROJECT-20H03426
[Journal Article] Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes2019
- Author(s)
  Suzuki Toru、Kikuguchi Chisato、Nishijima Saori、Nagashima Takeshi、Takahashi Akinori、Okada Mariko、Yamamoto Tadashi
- Journal Title
  
  Development
  
  Volume: 146
- DOI
  10.1242/dev.168146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07079, KAKENHI-PUBLICLY-17H06018, KAKENHI-PLANNED-17H06302, KAKENHI-PROJECT-18H04031
[Journal Article] The CCR4-NOT Deadenylase Complex Maintains Adipocyte Identity2019
- Author(s)
  Takahashi A., Takaoka S., Kobori S., Yamaguchi T., Ferwati S., Kuba K., Yamamoto T., and Suzuki T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Pages: 5274-5274
- DOI
  10.3390/ijms20215274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-18K15038
[Journal Article] Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob2011
- Author(s)
  Watanabe M., Suzuki T., Kim M., Abe Y., Yoshida Y., Sugano S., Yamamoto T.
- Journal Title
  
  FEBS letters 585巻
  
  Pages: 65-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770001
[Journal Article] Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation2002
- Author(s)
  T.Suzuki
- Journal Title
  
  Genes ＆ Dev 16
  
  Pages: 1357-1370
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219201
[Journal Article] A serine/threonine kinase p90rskl phosphorylates the antiproliferative protein Tob2001
- Author(s)
  T.Suzuki
- Journal Title
  
  Genes Cells 6
  
  Pages: 131-138
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219201
[Journal Article] A serine/threonine kinase p90rsk1 phosphorylates the antiproliferative protein Tob2001
- Author(s)
  T.Suzuki
- Journal Title
  
  Genes Cells 6
  
  Pages: 131-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12219201
[Journal Article] Differential involvement of Src family kinases in Fcγ receptor-mediated phagocytosis2000
- Author(s)
  T.Suzuki
- Journal Title
  
  J. Immunol. 165
  
  Pages: 473-482
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12219201
[Presentation] Essential role of Cnot7/8 catalytic subunits of the CCR4-NOT deadenylase complex in MEFs and liver2019
- Author(s)
  鈴木亨、Dina Mostafa、高橋明格、呉羽拓、栁谷明子、山本雅
- Organizer
  第21回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K07079
[Presentation] 肝・脂肪組織の恒常性維持におけるmRNA分解機構の役割2019
- Author(s)
  鈴木亨、高橋明格、西島さおり、久場敬二、山本雅
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07079
[Presentation] microRNAによる遺伝発現抑制過程におけるCCR-NOT脱アデニル化複合体の機能解析2018
- Author(s)
  坂村由梨佳、友廣拓生、大塚衆志、深尾亜喜良、船上仁範、高橋明格、鈴木亨、藤原俊伸
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07079
[Presentation] New insight into the mechanism of miRISC-induced translation repression in mammals2018
- Author(s)
  坂村由梨佳、友廣拓生、大塚衆志、深尾亜喜良、船上仁範、鈴木亨、山本雅、足達俊吾、夏目徹、藤原俊伸
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K07079
[Presentation] New insights into CCR4-Not deadenylase complex function in microRNA-mediated gene silencing2018
- Author(s)
  友廣拓生、坂村由梨佳、大塚衆志、深尾亜喜良、鈴木亨、山本雅、泊幸秀、藤原俊伸
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K07079
[Presentation] ストレス応答におけるCnot複合体によるmRNA分解の役割2018
- Author(s)
  鈴木亨、星名実幸、西島さおり、星名直祐、高橋明格、山本雅
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K07079
[Presentation] ストレス応答におけるCnot複合体によるmRNA分解の役割2018
- Author(s)
  西島さおり、鈴木亨、星名実幸、星名直祐、高橋明格、山本雅
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07079
[Presentation] Decision of DNA damage-induced apoptosis by regulating the Tob protein level2010
- Author(s)
  鈴木亨
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21770001
[Presentation] DNA損傷時のTob発現誘導の分子機構2010
- Author(s)
  鈴木亨
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪(大阪国際会議場)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21770001
[Presentation] Decision of DNA damage-induced apoptosis by regulating the Tob protein level2010
- Author(s)
  鈴木亨
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21770001
[Presentation] DNA損傷時のTob発現誘導の分子機構2010
- Author(s)
  鈴木亨
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪(大阪国際会議場)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21770001

1. YAMAMOTO Tadashi (40134621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 藤本一朗 (70264710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 藤元次郎 (60282521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 吉田富

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FUNAKAMI Yoshinori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. KUBA Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. MORITA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高橋明格

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 岡田眞里子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山口智和

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 鐘ヶ江裕美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. Wu Yibo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 一條秀憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 石川裕規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Suzuki Toru 鈴木 亨

鈴木 亨 スズキ トウル

SUZUKI Toru 鈴木 亨

Research Projects

Research Products

Co-Researchers

細胞間相互作用を介した肝再生機構の解明と再生肝細胞の起源の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the effects of cell growth and cell death regulation on tumor development using tumor mice modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖転移酵素遺伝子アレイの確立と応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞増殖抑制因子Tobの増殖・分化における役割とその発現制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌抑制遺伝子産物Tobによる細胞増殖制御機構と細胞の癌化・老化機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of cell growth and malignant transformation regulated by protein phosphorylation and dephosphorylation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insufficient liver maturation affects murine early postnatal hair cycle2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The CCR4?NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes2019

Author(s)

Journal Title

Suzuki Toru 鈴木亨

鈴木亨スズキトウル

SUZUKI Toru 鈴木亨