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Suzuki Toru  鈴木 亨

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… Alternative Names

SUZUKI Toru  鈴木 亨

鈴木 亨  スズキ トオル

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Researcher Number 50334280
Other IDs
Affiliation (Current) 2022: 東京大学, 医科学研究所, 助教
Affiliation (based on the past Project Information) *help 2021: 東京大学, 医科学研究所, 助教
2018 – 2020: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
2009 – 2010: The University of Tokyo, 医科学研究所, 助教
2007: 東京大学, 医科学研究所, 助教
2002 – 2005: 東京大学, 医科学研究所, 助手
Review Section/Research Field
Principal Investigator
Cell biology / Biological Sciences / Genetics/Genome dynamics / Basic Section 49030:Experimental pathology-related
Except Principal Investigator
Neurochemistry/Neuropharmacology / Biological Sciences
Keywords
Principal Investigator
Tob / DNA損傷応答 / DNA損傷 / 細胞周期 / リン酸化 / 増殖抑制 / 遺伝子発現誘導 / 間葉系細胞分化 / 発癌モデルマウス / 細胞死 … More / 発癌マウス / 癌抑制遺伝子Tob / アポトーシス / 肝再生 / 細胞外膜小胞 / マイクロRNA / 肝臓機能 / 細胞外膜成分 / miRNA / RNA / 肝臓形成 / 細胞間相互作用 … More
Except Principal Investigator
シグナル伝達 / 癌 / RNAi / 糖鎖 / マイクロアレイ / 生理活性 / 細胞増殖 / 癌抑制遺伝子 / 蛋白質リン酸化 / 転写因子複合体 / 遺伝子マウス改変 / 蛋白質 / 転写複合体 / プロテオーム / 蛋白質リン酸化反応 / 細胞周期 / 肺癌細胞株 / 遺伝子欠損マウス / Tob / Caf1 / CCR4 / NOT / LATS / Ndr / LATSファミリー / G1制御 / Tobファミリー蛋白質 / アダプター分子 / G2-Mチェックポイント / G1期制御 / cancer / cell growth / signal transduction- / tumor suppressor gene / protein phosphorylation / transcription factor complex / gene manipulated mice Less
  • Research Projects

    (6 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (18 People)
  •  Analysis of liver regeneration through cell-cell interaction and identification of origin of regenerated hepatocytesPrincipal Investigator

    • Principal Investigator
      Suzuki Toru
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      The University of Tokyo
      Institute of Physical and Chemical Research
  •  Analysis of the effects of cell growth and cell death regulation on tumor development using tumor mice modelsPrincipal Investigator

    • Principal Investigator
      SUZUKI Toru
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Genetics/Genome dynamics
    • Research Institution
      The University of Tokyo
  •  糖転移酵素遺伝子アレイの確立と応用

    • Principal Investigator
      藤本 一朗
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      The University of Tokyo
  •  細胞増殖抑制因子Tobの増殖・分化における役割とその発現制御機構の解析Principal Investigator

    • Principal Investigator
      鈴木 亨
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  癌抑制遺伝子産物Tobによる細胞増殖制御機構と細胞の癌化・老化機構の解析Principal Investigator

    • Principal Investigator
      鈴木 亨
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      The University of Tokyo
  •  Mechanisms of cell growth and malignant transformation regulated by protein phosphorylation and dephosphorylation

    • Principal Investigator
      YAMAMOTO Tadashi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

All 2022 2021 2020 2019 2018 2011 2010 2002 2001 2000

All Journal Article Presentation

  • [Journal Article] Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT22022

    • Author(s)
      Suzuki Toru、Hoshina Miyuki、Nishijima Saori、Hoshina Naosuke、Kikuguchi Chisato、Tomohiro Takumi、Fukao Akira、Fujiwara Toshinobu、Yamamoto Tadashi
    • Journal Title

      RNA Biology

      Volume: 19 Pages: 234-246

    • DOI

      10.1080/15476286.2021.2021676

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Journal Article] RNA decay machinery safeguards immune cell development and immunological responses2021

    • Author(s)
      Akiyama Taishin、Suzuki Toru、Yamamoto Tadashi
    • Journal Title

      Trends in Immunology

      Volume: 42 Pages: 447-460

    • DOI

      10.1016/j.it.2021.03.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-21K19391
  • [Journal Article] ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism.2020

    • Author(s)
      Otsuka Hiroshi、Fukao Akira、Tomohiro Takumi、Adachi Shungo、Suzuki Toru、Takahashi Akinori、Funakami Yoshinori、Natsume Toru、Yamamoto Tadashi、Duncan Kent E.、Fujiwara Toshinobu
    • Journal Title

      Biochimie

      Volume: 174 Pages: 49-56

    • DOI

      10.1016/j.biochi.2020.04.010

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-19K07929
  • [Journal Article] Insufficient liver maturation affects murine early postnatal hair cycle2020

    • Author(s)
      Suzuki T., Kikuguchi C, Nishijima S., and Yamamoto T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 521 Pages: 172-177

    • DOI

      10.1016/j.bbrc.2019.10.099

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Journal Article] Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.2020

    • Author(s)
      Mostafa Dina、Takahashi Akinori、Yanagiya Akiko、Yamaguchi Tomokazu、Abe Takaya、Kureha Taku、Kuba Keiji、Kanegae Yumi、Furuta Yasuhide、Yamamoto Tadashi、Suzuki Toru
    • Journal Title

      RNA Biol

      Volume: 17 Pages: 403-416

    • DOI

      10.1080/15476286.2019.1709747

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-18K15038, KAKENHI-PROJECT-20K08195
  • [Journal Article] Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation2020

    • Author(s)
      Mostafa D, Yanagiya A, Georgiadou E, Wu Y, Stylianides T, Rutter GA, Suzuki T*, Yamamoto T*
    • Journal Title

      Communications Biology

      Volume: 476 Pages: 1-16

    • DOI

      10.1038/s42003-020-01201-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-18H02425
  • [Journal Article] The CCR4?NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression2020

    • Author(s)
      Ito-Kureha Taku、Miyao Takahisa、Nishijima Saori、Suzuki Toru、Koizumi Shin-ichi、Villar-Briones Alejandro、Takahashi Akinori、Akiyama Nobuko、Morita Masahiro、Naguro Isao、Ishikawa Hiroki、Ichijo Hidenori、Akiyama Taishin、Yamamoto Tadashi
    • Journal Title

      Nature Communications

      Volume: 11 Pages: 6169-6169

    • DOI

      10.1038/s41467-020-19975-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-20K07332, KAKENHI-PUBLICLY-19H04821, KAKENHI-PROJECT-18H03995, KAKENHI-PROJECT-17K08622, KAKENHI-PROJECT-18K07237, KAKENHI-PROJECT-19K22547, KAKENHI-PROJECT-20H03441
  • [Journal Article] Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development2020

    • Author(s)
      Suzuki Toru、Adachi Shungo、Kikuguchi Chisato、Shibata Shinsuke、Nishijima Saori、Kawamoto Yurie、Iizuka Yusuke、Koseki Haruhiko、Okano Hideyuki、Natsume Tohru、Yamamoto Tadashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 9319-9319

    • DOI

      10.3390/ijms21239319

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-18K14840
  • [Journal Article] The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation.2020

    • Author(s)
      Takahashi Akinori、Suzuki Toru、Soeda Shou、Takaoka Shohei、Kobori Shungo、Yamaguchi Tomokazu、Mohamed Haytham Mohamed Aly、Yanagiya Akiko、Abe Takaya、Shigeta Mayo、Furuta Yasuhide、Kuba Keiji、Yamamoto Tadashi
    • Journal Title

      Life science alliance.

      Volume: 3 Pages: 1-19

    • DOI

      10.26508/lsa.201900494

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06975, KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-20K07285, KAKENHI-PROJECT-20K21566, KAKENHI-PROJECT-20H03426
  • [Journal Article] Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes2019

    • Author(s)
      Suzuki Toru、Kikuguchi Chisato、Nishijima Saori、Nagashima Takeshi、Takahashi Akinori、Okada Mariko、Yamamoto Tadashi
    • Journal Title

      Development

      Volume: 146

    • DOI

      10.1242/dev.168146

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07079, KAKENHI-PUBLICLY-17H06018, KAKENHI-PLANNED-17H06302, KAKENHI-PROJECT-18H04031
  • [Journal Article] The CCR4-NOT Deadenylase Complex Maintains Adipocyte Identity2019

    • Author(s)
      Takahashi A., Takaoka S., Kobori S., Yamaguchi T., Ferwati S., Kuba K., Yamamoto T., and Suzuki T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Pages: 5274-5274

    • DOI

      10.3390/ijms20215274

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-17H04028, KAKENHI-PROJECT-18K15038
  • [Journal Article] Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob2011

    • Author(s)
      Watanabe M., Suzuki T., Kim M., Abe Y., Yoshida Y., Sugano S., Yamamoto T.
    • Journal Title

      FEBS letters 585巻

      Pages: 65-70

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770001
  • [Journal Article] Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation2002

    • Author(s)
      T.Suzuki
    • Journal Title

      Genes & Dev 16

      Pages: 1357-1370

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12219201
  • [Journal Article] A serine/threonine kinase p90rskl phosphorylates the antiproliferative protein Tob2001

    • Author(s)
      T.Suzuki
    • Journal Title

      Genes Cells 6

      Pages: 131-138

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12219201
  • [Journal Article] A serine/threonine kinase p90rsk1 phosphorylates the antiproliferative protein Tob2001

    • Author(s)
      T.Suzuki
    • Journal Title

      Genes Cells 6

      Pages: 131-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12219201
  • [Journal Article] Differential involvement of Src family kinases in Fcγ receptor-mediated phagocytosis2000

    • Author(s)
      T.Suzuki
    • Journal Title

      J. Immunol. 165

      Pages: 473-482

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12219201
  • [Presentation] Role of mRNA Decay in Tissue Development and Homeostasis2021

    • Author(s)
      Toru Suzuki
    • Organizer
      International Conference on Cell Science & Molecular Biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] CCR4-NOT脱アデニル化酵素複合体に複数存在する活性因子の多様な役割2021

    • Author(s)
      鈴木亨
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] Essential role of Cnot7/8 catalytic subunits of the CCR4-NOT deadenylase complex in MEFs and liver2019

    • Author(s)
      鈴木亨、Dina Mostafa、高橋明格、呉羽拓、栁谷明子、山本雅
    • Organizer
      第21回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] 肝・脂肪組織の恒常性維持におけるmRNA分解機構の役割2019

    • Author(s)
      鈴木亨、高橋明格、西島さおり、久場敬二、山本雅
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] microRNAによる遺伝発現抑制過程におけるCCR-NOT脱アデニル化複合体の機能解析2018

    • Author(s)
      坂村由梨佳、友廣拓生、大塚衆志、深尾亜喜良、船上仁範、高橋明格、鈴木亨、藤原俊伸
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] New insight into the mechanism of miRISC-induced translation repression in mammals2018

    • Author(s)
      坂村由梨佳、友廣拓生、大塚衆志、深尾亜喜良、船上仁範、鈴木亨、山本雅、足達俊吾、夏目徹、藤原俊伸
    • Organizer
      第20回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] New insights into CCR4-Not deadenylase complex function in microRNA-mediated gene silencing2018

    • Author(s)
      友廣拓生、坂村由梨佳、大塚衆志、深尾亜喜良、鈴木亨、山本雅、泊幸秀、藤原俊伸
    • Organizer
      第20回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] ストレス応答におけるCnot複合体によるmRNA分解の役割2018

    • Author(s)
      鈴木亨、星名実幸、西島さおり、星名直祐、高橋明格、山本雅
    • Organizer
      第20回日本RNA学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] ストレス応答におけるCnot複合体によるmRNA分解の役割2018

    • Author(s)
      西島さおり、鈴木亨、星名実幸、星名直祐、高橋明格、山本雅
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K07079
  • [Presentation] Decision of DNA damage-induced apoptosis by regulating the Tob protein level2010

    • Author(s)
      鈴木亨
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21770001
  • [Presentation] DNA損傷時のTob発現誘導の分子機構2010

    • Author(s)
      鈴木亨
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21770001
  • [Presentation] Decision of DNA damage-induced apoptosis by regulating the Tob protein level2010

    • Author(s)
      鈴木亨
    • Organizer
      第33回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-21770001
  • [Presentation] DNA損傷時のTob発現誘導の分子機構2010

    • Author(s)
      鈴木亨
    • Organizer
      第69回 日本癌学会学術総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21770001
  • 1.  YAMAMOTO Tadashi (40134621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  藤本 一朗 (70264710)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  藤元 次郎 (60282521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  吉田 富
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  FUNAKAMI Yoshinori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  KUBA Keiji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 7.  MORITA Masahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  高橋 明格
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  岡田 眞里子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  柳谷 朗子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 11.  山口 智和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 12.  鐘ヶ江 裕美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  Wu Yibo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  秋山 伸子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  一條 秀憲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  石川 裕規
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  秋山 泰身
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  芝田 晋介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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