Kambe Naotomo 神戸直智

… Alternative Names

神戸直智カンベナオトモ

KAMBE Naotomo 神戸直智

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Researcher Number	50335254
Other IDs	https://orcid.org/0000-0001-9610-4952
External Links
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 京都大学, 医学研究科, 准教授 2020: 京都大学, 医学研究科, 特定准教授 2019: 関西医科大学, 医学部, 准教授 2017: 千葉大学, 医学(系)研究科(研究院), 准教授 2015: 千葉大学, 大学院・医学研究院, 准教授 … More 2015: 千葉大学, 大学院医学研究院, 准教授 2011 – 2015: 千葉大学, 医学(系)研究科(研究院), 准教授 2013: 千葉大学, 医学研究科, 講師 2011 – 2012: 千葉大学, 医学研究院, 准教授 2011: 千葉大学, 医学研究院, 講師 2010 – 2011: 千葉大学, 大学院・医学研究院, 准教授 2007 – 2010: Chiba University, 大学院・医学研究院, 講師 2006: 京都大学, 医学研究科, 助手 2005: 京都大学, 皮膚科学, 助手 2002 – 2004: 京都大学, 医学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Dermatology Except Principal Investigator Dermatology / Pediatrics
Keywords	Principal Investigator 肉芽腫 / 皮膚科学 / 肥満細胞 / 自己炎症 / ブラウ症候群 / NOD2 / 皮膚炎症・再生学 / インフラマソーム / IL-1β / 炎症 … More / 細胞死 / NLRP3 / 自然免疫 / ユビキチン化 / 翻訳後修飾 / リン酸化蛋白 / プロテオミクス / iPS細胞 / ＩＬ-33 / 皮膚硬化性病変 / コネキシン / Gap junction / 遺伝子 / 角化症 / 皮膚病理学 / カテプシン阻害剤 / 悪性黒色腫 / 転移 / 悪性腫瘍 / TAPtag法 / catyepsinB / 細胞内微生物認識受容体 / cathepsin B / ASC / 細胞内パターン認識受容体 / cryopyrin / CIAS1 / 免疫学 / 皮膚感染症 / CINCA症候群 / パターン認識受容体 / 自己炎症性疾患 / 家族性寒冷蕁麻疹 / 肥満細胞欠損マウス / 形質細胞様樹状細胞 / 免疫不全マウス / 細胞増殖 / aminopeptidase N / CD13 … More Except Principal Investigator NLRP3 / 樹状細胞 / インフラマソーム / 皮膚科学 / 臨床 / 免疫学 / 内科 / 自己炎症性疾患 / 体細胞モザイク / CINCA症候群 / 免疫抑制 / ギャップ結合 / エピジェネティクス / 血管炎 / ｱﾄﾋﾟｰ性皮膚炎 / ３次元方法由来表皮 / 皮膚炎症学 / 皮膚免疫学 / 毛包 / 責任遺伝子 / アトピー性皮膚炎 / 三次元表皮 / ケラチノサイト / mevalonate kinase / 自己炎症疾患 / 自然免疫 / 軟骨細胞 / 次世代シークエンサー / インフラマゾーム / 高IgD症候群 / CAPS / モザイシズム / IL-17 / IL-1β / 炎症 / 接触皮膚炎 / 抗炎症剤 / 薬剤反応性 / 生体分子 / iPS細胞 / 膠原病 / アレルギー / 小児免疫 / 動物モデル / 自己免疫性疾患 / バイオテクノロジー / 病理学 / 体細胞モデイク / 自己炎症症候群 / CIAS1 / 小児免疫・アレルギー・膠原病学 / 抗炎症作用 Less

Regulatory Mechanisms of Granulomatous Inflammation Focusing on Post-translational ModificationsPrincipal Investigator
- Principal Investigator
  
  神戸直智
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kyoto University
Analysis of molecular mechanism of granuloma formation by autoinflammationPrincipal Investigator
- Principal Investigator
  
  Kambe Naotomo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kyoto University
  Kansai Medical University
Application for a new less-invasive, personalized 3-demensional epidermal model: Search for new responsible genes related to Atopic Dermatitis
- Principal Investigator
  
  Matsue Hiroyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Gene-based analysis of NETs-associated DNA in autoantibody-mediated diseases
- Principal Investigator
  
  MATSUOKA YUMI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Analysis and development of medical treatment for autoinflammatory diseases
- Principal Investigator
  
  HEIKE TOSHIO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biologyPrincipal Investigator
- Principal Investigator
  
  KAMBE Naotomo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Gene analysis of epidermal gap junction and pathological search for palmoplantar hyperkeratosis associated with hearing impairmentsPrincipal Investigator
- Principal Investigator
  
  KAMBE Naotomo
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
インフラマソームの構成成分が関わる細胞死の人為的制御系の確立とそのメカニズム解明Principal Investigator
- Principal Investigator
  
  神戸直智
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Pathological analysis of skin fibrosis, focused on type 2 innate immune lymphoid cellsPrincipal Investigator
- Principal Investigator
  
  KAMBE Naotomo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Development of CINCA syndrome therapy based upon the pathophysiology of CINCA syndrome elucidated by cytoengineering.
- Principal Investigator
  
  NISHIKOMORI Ryuta
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Analysis of regulation of inflammation on the skin : Toward development of platform for new anti-inflammatory drug
- Principal Investigator
  
  MATSUE Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
抗ヒスタミン薬治療抵抗性慢性蕁麻疹におけるIL-1βを起点とする炎症病態の解明
- Principal Investigator
  
  岩澤真理
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
インフラマソームを介した悪性黒色腫の増殖および転移に関する研究Principal Investigator
- Principal Investigator
  
  神戸直智
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Study on causes and pathophysiology of CINCA syndrome patients without CIAS1 gene mutations
- Principal Investigator
  
  NISHIKOMORI Ryuta
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Molecular mechanism of cell death induced by the activation of intracellular pattern recognition receptor, cryopyrinPrincipal Investigator
- Principal Investigator
  
  KAMBE Naotomo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
DC Hybrids:皮膚自己免疫性疾患モデルの開発
- Principal Investigator
  
  松江弘之
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
免疫・炎症反応におけるギャップ結合の機能の解析及びギャップ結合阻害外用剤の開発
- Principal Investigator
  
  MATSUE Hiroyuki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
肥満細胞の活性化および分化における家族性寒冷刺激蕁麻疹原因遺伝子の役割Principal Investigator
- Principal Investigator
  
  神戸直智
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kyoto University
肥満細胞が形質細胞様樹状細胞の分化・機能に与える影響についての検証Principal Investigator
- Principal Investigator
  
  神戸直智
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Kyoto University
ヒト皮膚結合織型肥満細胞大量純粋培養系をモデルとした肥満細胞増殖機構の解明Principal Investigator
- Principal Investigator
  
  神戸直智
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kyoto University

[Book] II 各論 A 自己炎症性疾患 7. Blau 症候群/若年発症サルコイドーシス III 症例 Blau 症候群/若年発症サルコイドーシス「自己炎症性疾患・自然免疫不全症とその近縁疾患」2012
- Author(s)
  神戸直智
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23390280
[Book] II章.各論 A.自己炎症性疾患 7.Blau症候群／若年発症サルコイドーシス（自己炎症性疾患・自然免疫不全症とその近縁疾患）2011
- Author(s)
  神戸直智（近藤直美，平家俊男　編集）
- Total Pages
  7
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Potential benefits of TNF targeting therapy in Blau syndrome, a NOD2-associated systemic autoinflammatory granulomatosis.2022
- Author(s)
  Matsuda T, Kambe N, Takimoto-Ito R, Ueki Y, Nakamizo S, Saito MK, Takei S, Kanazawa N
- Journal Title
  
  Front Immunol
  
  Volume: 13 Pages: 895765-895765
- DOI
  10.3389/fimmu.2022.895765
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-22K08380
[Journal Article] Incomplete penetrance of NOD2 C483W mutation underlining Blau syndrome2022
- Author(s)
  Chang Shao-Yu、Kambe Naotomo、Fan Wen-Lang、Huang Jing-Long、Lee Wen-I、Wu Chao-Yi
- Journal Title
  
  Pediatric Rheumatology
  
  Volume: 20 Issue: 1
- DOI
  10.1186/s12969-022-00743-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08380
[Journal Article] Anti-TNF treatment corrects IFN-γ?dependent proinflammatory signatures in Blau syndrome patient?derived macrophages2022
- Author(s)
  Kitagawa Yohko、Kawasaki Yuri、Yamasaki Yuichi、Kambe Naotomo、Takei Syuji、Saito Megumu K.
- Journal Title
  
  Journal of Allergy and Clinical Immunology
  
  Volume: 149 Issue: 1 Pages: 176-188.e7
- DOI
  10.1016/j.jaci.2021.05.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08784, KAKENHI-PROJECT-20H03642
[Journal Article] NOD2 Mutation-Associated Case with Blau Syndrome Triggered by BCG Vaccination2021
- Author(s)
  Arakawa Akiko、Kambe Naotomo、Nishikomori Ryuta、Tanabe Akiyo、Ueda Masamichi、Nishigori Chikako、Miyachi Yoshiki、Kanazawa Nobuo
- Journal Title
  
  Children
  
  Volume: 8 Issue: 2 Pages: 117-117
- DOI
  10.3390/children8020117
- Data Source
  KAKENHI-PROJECT-19K08784
[Journal Article] Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated NOD2 Mutations2021
- Author(s)
  Nishiyama Mizuho、Li Hong-jin、Okafuji Ikuo、Fujisawa Akihiko、Ehara Mizue、Kambe Naotomo、Furukawa Fukumi、Kanazawa Nobuo
- Journal Title
  
  Children
  
  Volume: 8 Issue: 5 Pages: 335-335
- DOI
  10.3390/children8050335
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08784, KAKENHI-PROJECT-19K08798
[Journal Article] Blau Syndrome: NOD2-related systemic autoinflammatory granulomatosis2020
- Author(s)
  Takada S, Saito MK, Kambe N.
- Journal Title
  
  Giornale Italiano di Dermatologia e Venereologia
  
  Volume: 155 Issue: 5 Pages: 537-541
- DOI
  10.23736/s0392-0488.19.06524-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08784
[Journal Article] Spectrum of Genetic Autoinflammatory Diseases Presenting with Cutaneous Symptoms.2020
- Author(s)
  Bonnekoh H, Butze M, Kallinich T, Kambe N, Kokolakis G, Krause K.
- Journal Title
  
  Acta Derm Venereol.
  
  Volume: 100 Issue: 7 Pages: adv00091-151
- DOI
  10.2340/00015555-3427
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08784
[Journal Article] Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation2020
- Author(s)
  Matsuda, T. Kambe, N. Hosokawa, J. Ohara, O. Saito, M. K. Nishikomori, R.
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 79 Issue: 11 Pages: 1492-1499
- DOI
  10.1136/annrheumdis-2020-217320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-19K08784, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K08265, KAKENHI-PROJECT-18KK0228
[Journal Article] Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas2020
- Author(s)
  Furuya M, Iribe Y, Nagashima Y, Kambe N, Ohe C, Kinoshita H, Sato C, Kishida T, Okubo Y, Numakura K, Nanjo H, Nakaigawa N, Makiyama K, Hasumi H, Iwashita H, Ohta J, Kitamura H, Nakajima T, Yoshida T, Nakagawa M, Tanaka R, Yao M
- Journal Title
  
  Journal of Clinical Pathology
  
  Volume: 73 Issue: 12 Pages: 819-825
- DOI
  10.1136/jclinpath-2020-206548
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08713, KAKENHI-PROJECT-19K08784, KAKENHI-PROJECT-19K09717, KAKENHI-PROJECT-20K07395
[Journal Article] Low-frequency mosaicism in cryopyrin-associated periodic fever syndrome: mosaicism in systemic autoinflammatory diseases2019
- Author(s)
  Nishikomori, R. Izawa, K. Kambe, N. Ohara, O. Yasumi, T.
- Journal Title
  
  Int Immunol
  
  Volume: 31 Issue: 10 Pages: 649-655
- DOI
  10.1093/intimm/dxz047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-19K08784, KAKENHI-PROJECT-19K17293
[Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2014
- Author(s)
  Nakagawa K, Kawai T, Umebayashi H, Takei S, Kobayashi N, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI et al.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: in press Issue: 3 Pages: 1-8
- DOI
  10.1136/annrheumdis-2013-204361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249056, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24590681, KAKENHI-PROJECT-25460838, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062
[Journal Article] Ultra-pure soft water improves skin barrier function in children with atopic dermatitis: a randomized, double-blind, placebo-controlled, crossover pilot study.2014
- Author(s)
  Togawa Y, Kambe N, Shimojo N, Nakano T, Sato Y, Mochizuki H, Tanaka A, Matsuda H, Matsue H.
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: 76 Issue: 3 Pages: 269-271
- DOI
  10.1016/j.jdermsci.2014.10.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248055, KAKENHI-PROJECT-26293255
[Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2013
- Author(s)
  Nakagawa K, Gonzalez-Roca E, Souto A, Kawai T, Umebayashi H, Campistol JM, Cañellas J, Takei S, Kobayashi N, Callejas-Rubio JL, Ortego-Centeno N, Ruiz-Ortiz E, Rius F, Anton J, Iglesias E, Jimenez-Treviño S, Vargas C, Fernandez-Martin J, Calvo I, Hernández-Rodríguez J, Mendez M, Dordal MT, Basagaña M, Bujan S, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI
- Journal Title
  
  Ann Rheum Dis
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] NLRP3 activation induces ASCdependent programmed necrotic cell death, which leads to neutrophilic inflammation2013
- Author(s)
  Satoh T, Kambe N, Matsue H
- Journal Title
  
  Cell Death Dis
  
  Volume: 4 Issue: 5 Pages: e644-e644
- DOI
  10.1038/cddis.2013.169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280, KAKENHI-PROJECT-23659543, KAKENHI-PROJECT-24791136
[Journal Article] Monogenic early-onset sarcoidosis is no longer a variant of "idiopathic" sarcoidosis2013
- Author(s)
  Kanazawa N, T chernev G, Kambe N
- Journal Title
  
  J Am Acad Dermatol
  
  Volume: 69 Issue: 1 Pages: 164-5
- DOI
  10.1016/j.jaad.2012.12.976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280, KAKENHI-PROJECT-23591651
[Journal Article] 自然免疫と蕁麻疹2013
- Author(s)
  中川誠太郎, 神戸直智, 中村悠美
- Journal Title
  
  皮膚アレルギーフロンティア
  
  Volume: 11(1) Pages: 13-6
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Blau症候群／若年発症サルコイドーシス研究の現状と展望2013
- Author(s)
  中野倫代，神戸直智
- Journal Title
  
  日本臨床
  
  Volume: 71 Pages: 737-41
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 序　～自己炎症症候群の概説と現在提唱されている定義・分類～2013
- Author(s)
  江原瑞枝，神戸直智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 20 Pages: 1395-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Blau 症候群/若年発症サルコイドーシス研究の現状と展望2013
- Author(s)
  中野倫代, 神戸直智
- Journal Title
  
  日本臨床
  
  Volume: 71 Pages: 737-41
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 自然免疫と蕁麻疹2013
- Author(s)
  中川誠太郎，神戸直智，中村悠美
- Journal Title
  
  皮膚アレルギーフロンティア
  
  Volume: 11 Pages: 13-6
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 皮膚から診断する全身疾患　皮膚所見から考える自己炎症症候群2013
- Author(s)
  神戸直智
- Journal Title
  
  日皮会誌
  
  Volume: 123 Pages: 2826-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 序 ~自己炎症症候群の概説と現在提唱されている定義・分類~2013
- Author(s)
  江原瑞枝, 神戸直智
- Journal Title
  
  アレルギー・免疫
  
  Volume: 20 Pages: 1395-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 皮膚から診断する全身疾患皮膚所見から考える自己炎症症候群2013
- Author(s)
  神戸直智
- Journal Title
  
  日皮会誌
  
  Volume: 123 Pages: 2826-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Preferentially inflamed tendon sheaths in the swollen but not tender joints in a 5-year-old boy with Blau syndrome2013
- Author(s)
  Ikeda K, Kambe N, Satoh T, Matsue H, Nakajima H.
- Journal Title
  
  J Pediatr
  
  Volume: 163 Issue: 5 Pages: 1525-1525
- DOI
  10.1016/j.jpeds.2013.05.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Linkage of bacterial colonization of skin and the urticaria-like rash of NLRP3-mediated autoinflammatory syndromes through mast cell-derived TNF-α2013
- Author(s)
  Nakamura Y, Kambe N
- Journal Title
  
  J Der matol Sci
  
  Volume: 71 Issue: 2 Pages: 83-8
- DOI
  10.1016/j.jdermsci.2013.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 特集「蕁麻疹患者のQOL 向上術」蕁麻疹様皮疹を呈するクリオピリン関連周期性症候群の診断と管理2012
- Author(s)
  神戸直智
- Journal Title
  
  Monthly Book Derma デルマ
  
  Volume: 194 Pages: 63-9
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Kerion celsi due to Arthroderma incurvatum infection in a Sri Lankan child: species identification and analysis of area-dependent genetic polymorphism2012
- Author(s)
  Iwasawa M. T., Togawa Y, Akita F., Kambe N., Matsue H., Yaguchi T, Nishimura K
- Journal Title
  
  Medical Mycology
  
  Volume: 39 Issue: 7 Pages: 205-206
- DOI
  10.3109/13693786.2012.671968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390324, KAKENHI-PROJECT-23659543
[Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012
- Author(s)
  Tanaka T., Takahashi K., Yamane M., Tomida S., Nakamura S., Oshima K., Niwa A., Nishikomori R., Kambe N., Hara H., Mitsuyama M., Morone N., Heuse J.E., Yamamoto T., Watanabe A., Sato-Otsubo A., Ozawa S., Asaka I., Heike T., Yamanaka S., Nak
- Journal Title
  
  Blood
  
  Volume: 120(6) Issue: 6 Pages: 1299-308
- DOI
  10.1182/blood-2012-03-417881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22790283, KAKENHI-PROJECT-23310087, KAKENHI-PROJECT-23390280, KAKENHI-PROJECT-23657147, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-24659496
[Journal Article] 「皮膚免疫学-免疫臓器としての意義と病態」皮膚と自己炎症性機序による肉芽腫性疾患2012
- Author(s)
  中野倫代,神戸直智
- Journal Title
  
  医学のあゆみ
  
  Volume: 242 Pages: 791-4
- Data Source
  KAKENHI-PROJECT-24659520
[Journal Article] 連載「自己炎症症候群の多様性」CAPS でみられるヒスタミン非依存性蕁麻疹2012
- Author(s)
  神戸直智, 中村悠美
- Journal Title
  
  炎症と免疫
  
  Volume: 20 Pages: 183-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 「皮膚免疫学－免疫臓器としての意義と病態」皮膚と自己炎症性機序による肉芽腫性疾患.2012
- Author(s)
  中野倫代，神戸直智.
- Journal Title
  
  医学のあゆみ.
  
  Volume: 242 Pages: 791-4
- Data Source
  KAKENHI-PROJECT-24659520
[Journal Article] Maximum growth temperature test for cutaneous mycobacterium chelonae predicts the efficacy of thermal therapy2012
- Author(s)
  Ota R., Iwasawa M. T., Ohkusu K. , Kambe N., Matsue H
- Journal Title
  
  J Dermatol
  
  Volume: 39 Issue: 2 Pages: 205-206
- DOI
  10.1111/j.1346-8138.2011.01246.x
- NAID
  10031184871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390324
[Journal Article] Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the Nlrp3protein2012
- Author(s)
  Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Núñez G
- Journal Title
  
  Immunity
  
  Volume: 37 Issue: 1 Pages: 85-95
- DOI
  10.1016/j.immuni.2012.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 特集「皮膚免疫学－免疫臓器としての意義と病態」皮膚と自己炎症性機序による肉芽腫性疾患2012
- Author(s)
  中野倫代，神戸直智
- Journal Title
  
  医学のあゆみ
  
  Volume: 242 Pages: 791-4
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 特集「皮膚免疫学 -免疫臓器としての意義と病態」皮膚と自己炎症性機序による肉芽腫性疾患2012
- Author(s)
  中野倫代, 神戸直智
- Journal Title
  
  医学のあゆみ
  
  Volume: 242 Pages: 791-4
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] NLRP3インフラマソームを介したマスト細胞の活性化.2012
- Author(s)
  神戸直智，中村悠美.
- Journal Title
  
  臨床免疫・アレルギー科.
  
  Volume: 58 Pages: 560-4
- Data Source
  KAKENHI-PROJECT-24659520
[Journal Article] 特集「アナフィラキシーショック」 NLRP3 インフラマソームを介したマスト細胞の活性化2012
- Author(s)
  神戸直智, 中村悠美
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 58 Pages: 560-4
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 自己炎症症候群と皮膚疾患の関連　－治りにくい蕁麻疹（それと乾癬）について－2012
- Author(s)
  神戸直智
- Journal Title
  
  日皮会誌
  
  Volume: 122 Pages: 3286-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] NLRP3インフラマソームを介したマスト細胞の活性化2012
- Author(s)
  神戸直智,中村悠美
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 58 Pages: 560-4
- Data Source
  KAKENHI-PROJECT-24659520
[Journal Article] 特集「蕁麻疹患者のQOL向上術」蕁麻疹様皮疹を呈するクリオピリン関連周期性症候群の診断と管理.2012
- Author(s)
  神戸直智
- Journal Title
  
  Monthly Book Dermaデルマ
  
  Volume: 194 Pages: 63-9
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 特集「アナフィラキシーショック」　NLRP3インフラマソームを介したマスト細胞の活性化.2012
- Author(s)
  神戸直智，中村悠美
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 58 Pages: 560-4
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] The CD40-CD40L axis and IFN-γ play critical roles in Langhans giant cell formation2012
- Author(s)
  Sakai H, Okafuji I, Nishikomori R, Abe J, Izawa K, Kambe N, Y asumi T, Nakahata T, Heike T
- Journal Title
  
  Int Immunol
  
  Volume: 24 Issue: 1 Pages: 5-15
- DOI
  10.1093/intimm/dxr088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280, KAKENHI-PROJECT-24659496
[Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012
- Author(s)
  Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK
- Journal Title
  
  Blood
  
  Volume: 120 Pages: 1299-1308
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] 連載「自己炎症症候群の多様性」CAPSでみられるヒスタミン非依存性蕁麻疹2012
- Author(s)
  神戸直智，中村悠美
- Journal Title
  
  炎症と免疫
  
  Volume: 20 Pages: 183-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 自己炎症症候群と皮膚疾患の関連 -治りにくい蕁麻疹(それと乾癬)について-2012
- Author(s)
  神戸直智
- Journal Title
  
  日皮会誌
  
  Volume: 122 Pages: 3286-8
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Autoinflammatory diseases and the inflammasome: mechanisms of IL-1 beta activation leading to neutrophil-rich skin disorders.2011
- Author(s)
  Kambe N, Satoh T, Nakamura Y, Iwasawa M, Matsue H.
- Journal Title
  
  Inflammation Regeneration
  
  Volume: 31 Pages: 72-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Follicular keratosis and bullous formation are typical signs of extragenital lichen sclerosis2011
- Author(s)
  Kimura A, Kambe N, Satoh T, Togawa Y, Suehiro K, Matsue H
- Journal Title
  
  J Dermatol
  
  Volume: 38 Pages: 834-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659542
[Journal Article] 【抗体医療Update－開発コンセプトから最新治療実績まで】自己炎症性疾患に対する抗体療法2011
- Author(s)
  佐藤貴史，神戸直智
- Journal Title
  
  医学のあゆみ
  
  Volume: 238 Pages: 724-729
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Dermoscopy of keratosis follicularis squamosa2011
- Author(s)
  Nakano M, Kambe N, Satoh T, Togawa Y, Kamada N, Matsue H.
- Journal Title
  
  Dermatology Reports.
  
  Volume: 3 Issue: 2 Pages: e26-e26
- DOI
  10.4081/dr.2011.e26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659542
[Journal Article] 【蕁麻疹診療の実際-蕁麻疹診療ガイドライン改訂のポイント、薬物治療の評価を中心に-】クリオピリン関連周期性症候群の診断と治療2011
- Author(s)
  佐藤貴史，神戸直智
- Journal Title
  
  Progress in Medicine
  
  Volume: 31 Pages: 2811-2815
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Autoinflammatory diseases and the inflammasome : mechanisms of IL-1 beta activation leading to neutrophil- rich skin disorders2011
- Author(s)
  Kambe N, Satoh T, Nakamura Y, Iwasawa M, Matsue H
- Journal Title
  
  Inflammation Regeneration
  
  Volume: 31 Pages: 72-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Th17細胞と自己炎症性疾患2011
- Author(s)
  佐藤貴史，神戸直智
- Journal Title
  
  アレルギーの臨床
  
  Volume: 31 Pages: 218-222
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] インフラマソームの自発的活性化を病態とする自己炎症症候群2011
- Author(s)
  神戸直智，佐藤貴史，西小森隆太
- Journal Title
  
  生体の科学
  
  Volume: 62 Pages: 221-227
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 自己炎症性疾患からとらえたバイオインフォマティクス2011
- Author(s)
  神戸直智
- Journal Title
  
  皮膚アレルギーフロンティア
  
  Volume: 9 Pages: 130-6
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] インフラマソームの自発的活性化を病態とする自己炎症症候群2011
- Author(s)
  神戸直智, 佐藤貴史, 西小森隆太
- Journal Title
  
  生体の科学
  
  Volume: 62 Pages: 221-7
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome2011
- Author(s)
  Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Arostegui JI, Yague J, Merino R, Ibanez M, Pontillo A, Takada H, Imagawa T
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Issue: 11 Pages: 3625-32
- DOI
  10.1002/art.30512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390310, KAKENHI-PROJECT-21591363, KAKENHI-PUBLICLY-22021049, KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-23249056
[Journal Article] 【抗体医療Update -開発コンセプトから最新治療実績まで】自己炎症性疾患に対する抗体療法2011
- Author(s)
  佐藤貴史, 神戸直智
- Journal Title
  
  医学のあゆみ
  
  Volume: 238 Pages: 724-9
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 【蕁麻疹診療の実際-蕁麻疹診療ガイドライン改訂のポイント, 薬物治療の評価を中心に-】クリオピリン関連周期性症候群の診断と治療2011
- Author(s)
  佐藤貴史, 神戸直智
- Journal Title
  
  Progress in Medicine
  
  Volume: 31 Pages: 2811-5
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome2011
- Author(s)
  Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Aróstegui JI, Yagüe J, Merino R, Ibañez M, Pontillo A, Takada H, Imagawa T, Kawai T, Yasumi T, Nakahata T, Heike T
- Journal Title
  
  International Multicenter Collaborative Study
  
  Volume: 63 Pages: 3625-3632
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] Autoinflammatory diseases and the inflammasome : mechanisms of IL-1 beta activation leading to neutrophil-rich skin disorders2011
- Author(s)
  Kambe N, Satoh T, Nakamura Y, Iwasawa M, Matsue H
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 31-1 Pages: 72-80
- Data Source
  KAKENHI-PROJECT-21390324
[Journal Article] 自己炎症疾患の新しい知見】若年発症サルコイドーシス／Blau症候群2011
- Author(s)
  神戸直智，佐藤貴史，中野倫代，中村悠美，松江弘之
- Journal Title
  
  日本臨床免疫学会雑誌
  
  Volume: 34 Pages: 378-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Autoinflammatory diseases and the inflammasome : mechanisms of IL-1 beta activation leading to neutrophil-rich skin disorders.2011
- Author(s)
  Kambe N, Satoh T, Nakamura YIwasawa M, Matsue H.
- Journal Title
  
  Inflammation Regeneration
  
  Volume: 31 Pages: 72-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591455
[Journal Article] Lymphocutaneous Type of Nocardiosis Caused by Nocardia vinacea in a Patient with Polymyositis2011
- Author(s)
  Iwasawa M. T., Togawa Y., Kamada N., Kambe N., Matsue H., Yazawa K., Yaguchi T., Mikami Y
- Journal Title
  
  Mycopathologia
  
  Volume: 172 Issue: 1 Pages: 47-53
- DOI
  10.1007/s11046-011-9391-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390324
[Journal Article] Dermoscopy of keratosis follicularis squamosa2011
- Author(s)
  Nakano M, Kambe N, Satoh T, Togawa Y, Kamada N, Matsue H
- Journal Title
  
  Dermatology Reports
  
  Volume: 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659542
[Journal Article] Follicular keratosis and bullous formation are typical signs of extragenital lichen sclerosus2011
- Author(s)
  Kimura A., Kambe N. , Satoh T., Togawa Y., Suehiro K., Matsue, H
- Journal Title
  
  J Dermatol
  
  Volume: 38 Issue: 8 Pages: 834-836
- DOI
  10.1111/j.1346-8138.2010.01079.x
- NAID
  10031147105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390324
[Journal Article] Autoinflammatory diseases and the inflammasome: mechanisms ofIL-1 beta activation leading to neutrophil-rich skin disorders.2011
- Author(s)
  Kambe N, Satoh T, Nakamura Y, Iwasawa M, Matsue H.
- Journal Title
  
  Inflammation Regeneration
  
  Volume: 31 Pages: 72-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659203
[Journal Article] Th17 細胞と自己炎症性疾患2011
- Author(s)
  佐藤貴史, 神戸直智
- Journal Title
  
  アレルギーの臨床
  
  Volume: 31 Pages: 218-22
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] 【自己炎症疾患の新しい知見】若年発症サルコイドーシス/Blau 症候群2011
- Author(s)
  神戸直智, 佐藤貴史, 中野倫代, 中村悠美, 松江弘之
- Journal Title
  
  日本臨床免疫学会雑誌
  
  Volume: 34 Pages: 378-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390280
[Journal Article] Enhanced NF-kappaB activation with an inflammasome activator correlates with activity of autoinflammatory disease associated with NLRP3 mutations outside of exon 3 : comment on the article by Jeru et al.2010
- Author(s)
  Kambe, N., T.Satoh, H.Tanizaki, A.Fujisawa, M.K.Saito, R.Nishikomori
- Journal Title
  
  Arthritis Rheum
  
  Volume: 62 Pages: 3124-3125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390310
[Journal Article] The inflammasome, an innate immunity guardian, participates in skin urticarial reactions and contact hypersensitivity.2010
- Author(s)
  Kambe N, Nakamura Y, Saito M, Nishikomori R.
- Journal Title
  
  Allergol Int.
  
  Volume: 59 Pages: 105-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591455
[Journal Article] The inflammasome, an innate immunity guardian, participates in skin urticarial reactions and contact hypersensitivity.2010
- Author(s)
  Kambe N, Nakamura Y, Saito M, Nishikomori R.
- Journal Title
  
  Allergol Int. 59(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659265
[Journal Article] Enhanced NF-kappaB activation with an inflammasome activator correlates with disease activity of NLRP3 mutations outside of exon 3.2010
- Author(s)
  Kambe N, Satoh T, Tanizaki H, Fujisawa A, Saito MK, Nishikomori R.
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 62 Pages: 3123-3124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591455
[Journal Article] The inflammasome, an innate immunity guardian, participates in skin urticarial reactions and contact hypersensitivity.2010
- Author(s)
  Kambe, N., Y Nakamura, M.Saito, R.Nishikomori
- Journal Title
  
  Allergol Int
  
  Volume: 59 Pages: 105-113
- NAID
  10029669779
- Data Source
  KAKENHI-PROJECT-21390310
[Journal Article] Melanoma in association with acquired melanocytic nevus in Japan: A review of cases in the literature2010
- Author(s)
  Togawa Y., Nakamura, Y., Kamada, N., Kambe, N., Takahashi, Y., Matsue, H
- Journal Title
  
  Int J Dermatol
  
  Volume: 49 Issue: 12 Pages: 1362-1367
- DOI
  10.1111/j.1365-4632.2010.04602.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390324
[Journal Article] The inflammasome, an innate immunity guardian, participates inskin urticarial reactions and contact hypersensitivity.2010
- Author(s)
  Kambe N, Nakamura Y, Saito M, Nishikomori R.
- Journal Title
  
  Allergol Int.
  
  Volume: 59 Pages: 105-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659203
[Journal Article] Enhanced NF-kappaB activation with an inflammasome activatorcorrelates with disease activity of NLRP3 mutations outside of exon 3.2010
- Author(s)
  Kambe N, Satoh T, Tanizaki H, Fujisawa A, Saito MK, Nishikomori R.
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 62 Pages: 3123-3124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659203
[Journal Article] Enhanced NF-kappa activation with aninflammasome activator correlates with activity of auto inflammatory disease associated with NLRP3 mutations outside of exon 32010
- Author(s)
  Kambe, N., Satoh, T., Tanizaki, H., Fujisawa, A., Saito, M. K. & Nishikomori, R
- Journal Title
  
  Arthritis Rheum
  
  Volume: 62 Issue: 10 Pages: 3124-3125
- DOI
  10.1002/art.27619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390310
[Journal Article] Murine fetal skin-derived cultured mast cells : A useful tool for discovering novel functions of skin mast cells2009
- Author(s)
  Matsue H, Kambe N, Shimada S
- Journal Title
  
  J Invest Dermatol
  
  Volume: 129 Issue: 5 Pages: 1120-1125
- DOI
  10.1038/jid.2009.44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390324
[Journal Article] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria2009
- Author(s)
  Nakamura Y, Kambe N, Saito M, Nishikomori R, Kim YG, Murakami M, Nunez G, Matsue H.
- Journal Title
  
  J Exp Med (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis2009
- Author(s)
  Okafuji I, anishikomori R, Kanazawa N, Kambe N, et al.
- Journal Title
  
  Arthritis Rheum 60
  
  Pages: 242-250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Role of NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis2009
- Author(s)
  Okafuji I., R. Nishikomori, N. Kanazawa, N. Kambe, A. Fujisawa, S. Yamazaki, M. Saito, T. Yoshioka, T. Kawai, H. Sakai, H. Tanizaki, T. Heike, Y. Miyachi, T. Nakahata
- Journal Title
  
  Arthritis Rheum 60
  
  Pages: 242-250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591249
[Journal Article] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria2009
- Author(s)
  Nakamura Y, Kambe N, et al.
- Journal Title
  
  J Exp med (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria2009
- Author(s)
  Nakamura, Y., Kambe, N., Saito, M., Nishikomori, R., Kim, Y. G., Murakami, M., Nunez, G. & Matsue, H.
- Journal Title
  
  J Exp Med
  
  Volume: 206 Issue: 5 Pages: 1037-1046
- DOI
  10.1084/jem.20082179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390310, KAKENHI-PROJECT-21390324
[Journal Article] Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis2009
- Author(s)
  Okafuji, I., Nishikomori, R., Kanazawa, N., Kambe, N., Fujisawa, A., Yamazaki, S., Saito, M., Yoshioka, T., Kawai, T., Sakai, H., Tanizaki, H., Heike, T., Miyachi, Y. & Nakahata, T.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 60 Issue: 1 Pages: 242-250
- DOI
  10.1002/art.24134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390310
[Journal Article] Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis2009
- Author(s)
  Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, Saito M, Yoshioka T, Kawai T, Sakai H, Tanizaki H, Heike T, Miyachi Y, Nakahata T.
- Journal Title
  
  Arthritis Rheum 60
  
  Pages: 242-250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin associated periodic syndrome patients2008
- Author(s)
  Saito, M., R. Nishikomori, N. Kambe, A. Fujisawa, H. Tanizaki, K. Takeichi, T. Imagawa, T. Iehara, H. Takada, T. Matsubayashi, H. Tanaka, H. Kawashima, K. S. Kagami, I. Okafuji, T. Yoshioka, S. Adachi, T. Heike, Y. Miyachi, T. Nakahata
- Journal Title
  
  Blood 111
  
  Pages: 2132-2141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591249
[Journal Article] Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients2008
- Author(s)
  Saito M, Nishikomori R, Kambe N, Fujisawa A, Tanizaki H, Takeichi K, Imagawa T, Iehara T, Takada H, Matsubayashi T, Tanaka H, Kawashima H, Kawakami K, Kagami S, Okafuji I, Yoshioka T, Adachi S, Heike T, Miyachi Y, Nakahata T.
- Journal Title
  
  Blood 111
  
  Pages: 2132-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Disease-associated CIAS1 mutations induce monocyte death,revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients2008
- Author(s)
  Saito M, Nishikomori R, Kambe N, et. al.
- Journal Title
  
  Blood 111
  
  Pages: 2132-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells2007
- Author(s)
  Fujisawa A, Kambe N, et. al.
- Journal Title
  
  Blood 109
  
  Pages: 2903-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Disease-associated mutation in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic2007
- Author(s)
  Fujisawa A, Kambe N, et al.
- Journal Title
  
  Blood 109
- Data Source
  KAKENHI-PROJECT-17790766
[Journal Article] Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells2007
- Author(s)
  Fujisawa A, Kambe N, Saito M, Nishikomori R, Tanizaki H, Kanazawa N, Adachi S, Heike T, Sagara J, Suda T, Nakahata T, Miyachi Y.
- Journal Title
  
  Blood 109
  
  Pages: 2903-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591303
[Journal Article] Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells2007
- Author(s)
  Fujisawa A., N. Kambe, M. Saito, R. Nishikomori, H. Tanizaki, N. Kanazawa, S. Adachi, T. Heike, J. Sagara, T. Suda, T. Nakahata and Y. Miyachi
- Journal Title
  
  Blood 109
  
  Pages: 2903-2911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591249
[Journal Article] Replay2006
- Author(s)
  Saito H, Fujisawa A, Nishikomori R, Kambe N, et al.
- Journal Title
  
  Arthritis Rheum 54
- Data Source
  KAKENHI-PROJECT-17790766
[Journal Article] 家族性寒冷蕁麻疹原因遺伝子CIAS1の肥満細胞における役割2005
- Author(s)
  神戸直智, 藤澤章弘, 宮地良樹
- Journal Title
  
  アレルギー・免疫 12
  
  Pages: 1046-1052
- Data Source
  KAKENHI-PROJECT-17790766
[Journal Article] The cytosolic pattern-recognition receptor Nod2 and inflammatory grallulomatous disorders.2005
- Author(s)
  Kambe N, Nishikomori R, Kanazawa N
- Journal Title
  
  J Dermatol Sci. 39
  
  Pages: 71-80
- Data Source
  KAKENHI-PROJECT-17790766
[Journal Article] 肥満細胞の分化機構と病態的役割2005
- Author(s)
  神戸直智, 宮地良樹, 中畑龍俊
- Journal Title
  
  日小血会誌 19
  
  Pages: 113-122
- NAID
  10016462324
- Data Source
  KAKENHI-PROJECT-17790766
[Journal Article] Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome.2005
- Author(s)
  Saito M, Fujisawa A, Nishikomori R, Kambe N, et al.
- Journal Title
  
  Arthritis Rheum. 52
  
  Pages: 3579-3585
- Data Source
  KAKENHI-PROJECT-17790766
[Presentation] 診断力を磨こう　診断困難例の診断プロセスに学ぶ　自己炎症を疑う場合2022
- Author(s)
  神戸直智
- Organizer
  第121回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08380
[Presentation] NOD2-related systemic autoinflammatory granulomatosis, Blau syndrome2019
- Author(s)
  Takada S, Kambe N.
- Organizer
  24th World Congress of Dermatology, Milan, Italy（Workshop）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08784
[Presentation] Gain-of-function mutation of NOD2 impairs its ligand specific immune responses in Blau syndrome patient-derived iPS cells2019
- Author(s)
  Kambe N, Ly NTM, Saito KM, Okamoto H.
- Organizer
  10th International Congress 2019 FMF and Systemic Auto Inflammatory Diseases, Genova, Italy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08784
[Presentation] 教育講演32「皮膚から診断する全身疾患」皮膚所見から考える自己炎症症候群2013
- Author(s)
  神戸直智
- Organizer
  第112回日本皮膚科学会総会
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] ワークショップ「多彩な細胞死の実行制御と生体応答」Pyronecrosis : 細胞内パターン認識受容体 NLRP3 の活性化によって誘導されるプログラム細胞死2013
- Author(s)
  神戸直智, 佐藤貴史
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 教育講演32「皮膚から診断する全身疾患」皮膚所見から考える自己炎症症候群2013
- Author(s)
  神戸直智
- Organizer
  第112回日本皮膚科学会総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 若年発症サルコイドーシスへの治療介入時の評価項目としての関節エコーの有用性2013
- Author(s)
  神戸直智, 佐藤貴史, 中野倫代, 松江弘之, 池田啓, 西小森隆太, 金澤伸雄, 武井修治
- Organizer
  第65回日本皮膚科学会西部支部学術大会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] ワークショップ「多彩な細胞死の実行制御と生体応答」Pyronecrosis: 細胞内パターン認識受容体NLRP3の活性化によって誘導されるプログラム細胞死2013
- Author(s)
  神戸直智，佐藤貴史
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 分野別シンポジウム8「自己炎症性疾患の基礎と臨床」若年発症サルコイドーシス／Blau症候群2013
- Author(s)
  神戸直智
- Organizer
  第116回日本小児科学会学術集会
- Place of Presentation
  広島市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Programmed necrosis by CAPS-associated NLRP32013
- Author(s)
  Satoh T , Kambe N, Matsue H
- Organizer
  7th International Congress of FMF and AIDs
- Place of Presentation
  Lausanne, Switzerland
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 分野別シンポジウム 8「自己炎症性疾患の基礎と臨床」若年発症サルコイドーシス/Blau 症候群2013
- Author(s)
  神戸直智
- Organizer
  第116回日本小児科学会学術集会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Programmed cell death induced by CAPS-associated mutant NLRP3 features necrosis that leads to in vivo neutrophilic inflammation2013
- Author(s)
  Satoh T , Kambe N, Matsue H
- Organizer
  International Investigative Dermatology 2013
- Place of Presentation
  Edinburgh, UK
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Programmed cell death induced by CAPS-associated mutant NLRP3 features necrosis that leads to in vivo neutrophilic inflammation.2013
- Author(s)
  Satoh T, Kambe N, Matsue H
- Organizer
  International Investigative Dermatology 2013
- Place of Presentation
  Edinburgh, UK
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Programmed necrosis by CAPS-associated NLRP3.2013
- Author(s)
  Satoh T, Kambe N, Matsue H
- Organizer
  7th International Congress of FMF and AIDs
- Place of Presentation
  Lausanne, Switzerland
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 教育講演3　アレルギーと自己炎症症候群2012
- Author(s)
  神戸直智
- Organizer
  第24回日本アレルギー学会春期臨床大会
- Place of Presentation
  大阪市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 教育講演17「炎症と免疫」自己炎症症候群と皮膚疾患の関連　－治りにくい蕁麻疹について－2012
- Author(s)
  神戸直智
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Seminar 1. Urticaria and innate immunity. Innate Immunity and autoinflammation.2012
- Author(s)
  Kambe N
- Organizer
  37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  那覇市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] JSID A ward Lecture. The genetic fedelity of the dead or dysing2012
- Author(s)
  Kambe N
- Organizer
  37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Okinawa
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Critical role for mast cells in IL-1β-driven skin inflammation accompanying a disease-associated Nlrp3 mutation2012
- Author(s)
  Nakamura Y, Franchi L, Kambe N, Meng G, Strober W, Nunez G.
- Organizer
  42nd Annual ESDR Meeting
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] シンポジウム 1「臨床から見た自己炎症症候群」皮膚症状から見た自己炎症症候群2012
- Author(s)
  神戸直智
- Organizer
  第22回日本小児リウマチ学会総会・学術大会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] JSID Award Lecture. The genetic fedelity of the dead or dysing.2012
- Author(s)
  Kambe N.
- Organizer
  37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  那覇市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 教育講演17「炎症と免疫」自己炎症症候群と皮膚疾患の関連-治りにくい蕁麻疹について-2012
- Author(s)
  神戸直智
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 手根管長および関節エコーによる若年発症サルコイドーシスにおける関節炎病態の検討2012
- Author(s)
  赤池治美, 久保田知洋, 山崎雄一, 山遠剛, 野中由希子, 根路銘安仁, 嶽崎智子, 今中啓之, 池田啓, 神戸直智, 武井修治
- Organizer
  第22回日本小児リウマチ学会総会・学術大会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 教育講演3アレルギーと自己炎症症候群2012
- Author(s)
  神戸直智
- Organizer
  第24回日本アレルギー学会春期臨床大会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] シンポジウム1「臨床から見た自己炎症症候群」皮膚症状から見た自己炎症症候群2012
- Author(s)
  神戸直智
- Organizer
  第22回日本小児リウマチ学会総会
- Place of Presentation
  名古屋市
- Invited
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Programed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation2012
- Author(s)
  Satoh T , Kambe N, Matsue H
- Organizer
  42nd Annual ESDR Meeting, 2012
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Seminar 1. Urticaria and innate immunity . Innate Immunity and autoinflammation2012
- Author(s)
  Kambe N
- Organizer
  37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Okinawa
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Programmed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation2012
- Author(s)
  Satoh T , Kambe N, Matsue H
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Critical role for mast cells in IL-1β-driven skin inflammation accompanying a diseaseassociated Nlrp3 mutation2012
- Author(s)
  Nakamura Y , Franchi L, Kambe N, G Meng G , Strober W, Núñez G
- Organizer
  42nd Annual ESDR Meeting
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 手根管長および関節エコーによる若年発症サルコイドーシスにおける関節炎病態の検討2012
- Author(s)
  赤池治美，久保田知洋，山﨑雄一，山遠　剛，野中由希子，根路銘安仁，嶽崎智子，今中啓之，池田　啓，神戸直智，武井修治
- Organizer
  第22回日本小児リウマチ学会総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Programed necrotic cell death caused by NLRP3 activation is dispensable for TLR stimulation2012
- Author(s)
  Satoh T, Kambe N, Matsue H.
- Organizer
  42nd Annual ESDR Meeting
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Oligomerization of NLRP3 is induced dwonstream of cathepsin B in NLRP3-induced rapid programmed cell death2011
- Author(s)
  Satoh T, Kambe N, Matsue H
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-21390324
[Presentation] Peripheral CD14+ monocytes from early-onset sarcoidosis associated with NOD2 mutation do not show the molecular signature of NF-kappa B signaling2011
- Author(s)
  Kambe N, Satoh T , Matsue H
- Organizer
  41st Annual ESDR Meeting
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Oligomerization of NLRP3 is induced dwonstream of cathepsin B in NLRP3-induced rapid programmed cell death2011
- Author(s)
  Satoh T , Kambe N, Matsue H
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉市幕張
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 限局性掌蹠角化症の1例2011
- Author(s)
  林郁伶, 神戸直智, 田島綾子, 松江弘之, 高橋健造
- Organizer
  第26回角化症研究会
- Place of Presentation
  東京
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-23659542
[Presentation] シンポジウム 11 : アナフィラキシー NLRP3 インフラマソームを介したマスト細胞の活性化2011
- Author(s)
  神戸直智
- Organizer
  第61回日本アレルギー学会秋季学術大会
- Place of Presentation
  品川
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 若年発症サルコイドーシス/ブラウ症候群に関連する NOD2 遺伝子変異を組み込んだTHP-1 細胞は, phorbol myristate acetate添加により細胞表面に ICAM-1 を長期発現し, 一時的に PDGF-B を産生する2011
- Author(s)
  西山瑞穂, 李洪錦, 古川福実, 金澤伸雄, 岡藤郁夫, 神戸直智
- Organizer
  第424回日本皮膚科学会大阪地方会
- Place of Presentation
  大阪市
- Year and Date
  2011-03-19
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 自己炎症性肉芽腫形成におけるICAM-1とPDGF-Bの関与2011
- Author(s)
  金澤伸雄, 岡藤郁夫, 神戸直智, 古川福実
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome2011
- Author(s)
  Kambe N, Nakamura Y
- Organizer
  22nd World Conference of Dermatology
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Homopolymerization of ASC using FKBP12 chimeric protein induced rapid cell death accompanied with IL-1 beta processing2011
- Author(s)
  Satoh T, Kambe N, Matsue H
- Organizer
  41st Annual ESDR Meeting
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21390324
[Presentation] 日本皮膚科学会認定皮膚科専門医研修講習会(西部支部企画)自己炎症性疾患その疾患概念と臨床症状2011
- Author(s)
  神戸直智
- Organizer
  第63回日本皮膚科学会西部支部学術大会
- Place of Presentation
  宜野湾市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] NLRP3 体細胞モザイクは CINCA 症候群の 25%以上に認められる2011
- Author(s)
  田中尚子, 井澤和司, 西小森隆太, 神戸直智, 河合朋樹, 酒井秀政, 八角高裕, 平家俊男
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Homopolymerization of ASC using FKBP12 chimeric protein induced rapid cell death accompanied with IL-1 beta processing2011
- Author(s)
  Satoh T , Kambe N, Matsue H
- Organizer
  41st Annual ESDR Meeting
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] Peripheral CD14+ monocytes from early-onset sarcoidosis associated with NOD2 mutation do not show the molecular signature of NF-kappa B signaling2011
- Author(s)
  Kambe N, Satoh T, Matsue H
- Organizer
  41st Annual ESDR Meeting
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21390324
[Presentation] 自己炎症性肉芽腫形成における ICAM-1 と PDGF-B の関与2011
- Author(s)
  金澤伸雄, 岡藤郁夫, 神戸直智, 古川福実
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] 日本皮膚科学会認定皮膚科専門医研修講習会（西部支部企画）2011
- Author(s)
  神戸直智
- Organizer
  第63回日本皮膚科学会西部支部学術大会
- Place of Presentation
  沖縄県宜野湾市
- Data Source
  KAKENHI-PROJECT-23390280
[Presentation] High incidence of nlrp3 somatic mosaicism in chronic infantile neurological cutaneous andarticular syndrome patients : a report from an international multicenter collaborative study2011
- Author(s)
  R. Nishikomori, N. Tanikaze, K. Izawa, M. K. Saito, R. Goldbach-ManskyI. Aksentijevich, G. de Saint Basile, B. Neven, J. Frenkel, M. Van Gijn, J. I. Arostegui, J. Yague, T. Morimoto, M. Sakuma, N. Kambe, T. Yasumi, T. Kawai, A. Pontillo, K. Oshima, H. Tak
- Organizer
  OP0142 : Annual European Congress of Rheumatology EULAR
- Place of Presentation
  London, United Kingdom
- Data Source
  KAKENHI-PROJECT-21390310
[Presentation] シンポジウム「皮膚アレルギー学の未来」分子標的薬が明らかにする尊麻疹の病態2010
- Author(s)
  神戸直智
- Organizer
  第40回日本皮膚アレルギー・接触皮膚炎学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22659203
[Presentation] シンポジウム「Autoinflammation vs Autoi-1Ty」Autoinflammationによる皮膚疾患の発症機序2010
- Author(s)
  神戸直智
- Organizer
  第31回日本炎症・再生医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22659203
[Presentation] シンポジウム「自己炎症症候群の新しい展開」CAPSにみられるヒスタミン非依存性奪麻疹2010
- Author(s)
  神戸直智
- Organizer
  第54回日本リウマチ学会総会・学術大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22659203
[Presentation] Enhanced NF-kappaB activation with NLRP3 activator correlates with disease activities in cryopyin-associated periodic syndrome2010
- Author(s)
  Satoh T, Kambe N, Matsue H
- Organizer
  40th Annual ESDR Meeting
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-21390324
[Presentation] シンポジウム「自己炎症症候群の新しい展開」CAPSにみられるヒスタミン非依存性奪麻疹2010
- Author(s)
  神戸直智
- Organizer
  第54回日本リウマチ学会総会・学衛大会
- Place of Presentation
  神戸
- Year and Date
  2010-04-22
- Data Source
  KAKENHI-PROJECT-21591455
[Presentation] シンポジウム「Autoinflammation vs Autoimmuaity」Autoinflammationによ.る皮膚疾患の発症機序2010
- Author(s)
  神戸直智
- Organizer
  第31回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-21591455
[Presentation] シンポジウム「皮膚アレルギー学の未来」分子標的薬が明らかにする奪麻疹の病態2010
- Author(s)
  神戸直智
- Organizer
  第40回日本皮膚アレルギー・接触皮膚炎学会
- Place of Presentation
  広島
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21591455
[Presentation] Enhanced NF-kappaB activation after the stimulation with NLRP3 activator correlates with disease activities in cryopyin-associated periodic syndrome2010
- Author(s)
  Satoh T, Kambe N, Saito M, Nishikomori R, Matsue H
- Organizer
  Autoinflammation
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-21390324
[Presentation] Endogenous danger signal ATP activates the NLRP3-inflammasome in mast cells depending on K+ efflux through P2RX72009
- Author(s)
  神戸直智, Nakamura Y, 松江弘之
- Organizer
  日本研究皮膚科学会第34回年次学術大会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-21659265
[Presentation] Mast cells in CAPS evoke skin rash by promoting Th17 differentiation through inflammasome activation2009
- Author(s)
  Satoh T, Kambe N, Nakamura Y, Kabashima K, Suto A, Nakajima H.
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21591455
[Presentation] Th17 mediates urticarial rash in CAPS induced by inflammasome activation2009
- Author(s)
  Satoh T, Kambe N, Nakamura Y, Kabashima K, Matsue H.
- Organizer
  日本研究皮膚科学会第34回年次学術大会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-21591455
[Presentation] NLRP3-inflammasomeを介したIL-1β産生とヒスタミン非依存性蕁麻疹2009
- Author(s)
  神戸直智
- Organizer
  第18回東京免疫フォーラム
- Place of Presentation
  東京
- Year and Date
  2009-03-12
- Data Source
  KAKENHI-PROJECT-19591303
[Presentation] AI(Autopsy Imaging)を行った悪性黒色腫の1例2009
- Author(s)
  佐藤貴史, 小野泰伸, 小俣渡, 岩澤真理, 末廣敬祐, 鎌田憲明, 神戸直智, 松江弘之, 山本正二, 高橋葉子
- Organizer
  第73回日本皮膚科学会東部支部学術大会
- Place of Presentation
  甲府
- Data Source
  KAKENHI-PROJECT-21659265
[Presentation] Cryopyrin-associated IL-1 beta secretion in mast cells and a role played by mast cells in autoinflammatory disorders.2008
- Author(s)
  Nakamura Y, Kambe N, et al.
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19591303
[Presentation] A case of early-onset sarcoidosis who showed spontaneous regression of his clinical manifestations but inherited skin eruption to his baby : What should we call this systemic inflammatory granulomatosis associated with NOD2 mutation2008
- Author(s)
  Kambe N, Nakamura Y, Okafuji I, Nishikomori R, Kanazawa N, Matsue H.
- Organizer
  V International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases
- Place of Presentation
  Rome, Itary
- Data Source
  KAKENHI-PROJECT-19591303
[Presentation] 肥満細胞に発現するNLRP3インフラマソームを介したIL-1βの産生は生体内で好中球主体の炎症と血管透過性の亢進を誘導する2008
- Author(s)
  中村悠美, 神戸直智, 松江弘之
- Organizer
  第15回分子皮膚科学フォーラム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591303
[Presentation] NLRP3の活性化によって誘導されるpyronecrosisの分子学的機序2008
- Author(s)
  佐藤貴史, 中村悠美, 神戸直智, 松江弘之
- Organizer
  第15回分子皮膚科学フォーラム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591303
[Presentation] 自己炎症性疾患において肥満細はNLRP3 inflammasomeを介して好中球遊走と血管透過性を制御する2008
- Author(s)
  中村悠美, 神戸直智, 松江弘之
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591303
[Presentation] Cryopyrin-associated IL-1 beta secretion inmast cells and a role played by mast cells in autoinflammatory disorders2008
- Author(s)
  Nakamura Y, Kambe N, Matsue H.
- Organizer
  International Investigative Dermatology
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19591303
[Presentation] Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients2007
- Author(s)
  Saito M.,R. Nishikomori, N. Kambe, A. Fujisawa, H. Tanizaki, T. Kawai, H. Sakai, I. Okafuji, T. Yoshioka, S. Adachi, T. Heike, Y. Miyachi, T. Nakahata
- Organizer
  71st ACR annual meeting
- Place of Presentation
  Boston MA
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19591249
[Presentation] 乳児皮膚に生着した黄色ブドウ球菌Agrクオラムセンシング機構発現とアトピー性皮膚炎
- Author(s)
  松岡悠美、片山有紀、岩澤真理、江原瑞枝、神戸直智、松江弘之、下条直樹
- Organizer
  第21回分子皮膚科学フォーラム
- Place of Presentation
  京都国際ホテル（京都市）
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-26293255

1. MATSUE Hiroyuki (10250424)

# of Collaborated Projects: 6 results

# of Collaborated Products: 34 results
2. NISHIKOMORI Ryuta (70359800)

# of Collaborated Projects: 6 results

# of Collaborated Products: 29 results
3. KAMADA Noriaki (00334186)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
4. OHARA Osamu (20370926)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. YAO Jian (50303128)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HEIKE Toshio (90190173)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. MATSUOKA YUMI (10402067)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 末廣敬祐 (50375721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. YASUMI Takahiro (00511891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. SAITO Megumu (90535486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAHATA Tatsutoshi (20110744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. NAKAE Susumu (60450409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松村由美 (10362493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 柴垣直孝 (40262662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 原田和俊 (20324197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 岩澤真理 (70375723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 中野倫代 (20645634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OSHIMA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. NIWA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. MATSUDA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. IZAWA Kazushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 金澤伸雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 田中あかね

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 松田浩珍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 大久保陽一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kambe Naotomo 神戸 直智

神戸 直智 カンベ ナオトモ

KAMBE Naotomo 神戸 直智

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Regulatory Mechanisms of Granulomatous Inflammation Focusing on Post-translational ModificationsPrincipal Investigator

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Analysis of molecular mechanism of granuloma formation by autoinflammationPrincipal Investigator

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Molecular mechanism on granuloma formation based on the analysis with cellular and molecular biologyPrincipal Investigator

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Gene analysis of epidermal gap junction and pathological search for palmoplantar hyperkeratosis associated with hearing impairmentsPrincipal Investigator

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インフラマソームの構成成分が関わる細胞死の人為的制御系の確立とそのメカニズム解明Principal Investigator

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Pathological analysis of skin fibrosis, focused on type 2 innate immune lymphoid cellsPrincipal Investigator

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インフラマソームを介した悪性黒色腫の増殖および転移に関する研究Principal Investigator

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Kambe Naotomo 神戸直智

神戸直智カンベナオトモ

KAMBE Naotomo 神戸直智