Hagihara Yoshihisa 萩原義久

… Alternative Names

萩原義久ハギハラヨシヒサ

Hagihara Yoshihis 萩原義久

HAGIHARA Yoshihisa 萩原義久

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Researcher Number	50357761
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究部門長
Affiliation (based on the past Project Information) *help	2022: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究部門長 2020 – 2022: 国立研究開発法人産業技術総合研究所, 生命工学領域, 副研究部門長 2017 – 2018: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究部門付 2017: 国立研究開発法人産業技術総合研究所 2017: 独立行政法人産業技術総合研究所, 創薬基盤研究部門, 副研究部門長 … More 2016: 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究部門付 2012: 独立行政法人産業技術総合研究所, 健康工学研究部門, ストレスシグナル研究グループ長 2011 – 2012: 独立行政法人産業技術総合研究所, 健康工学研究部門, 研究グループ長 2008: National Institute of Advanced Industrial Science and Technology, セルエンジニアリング研究部門, 研究グループ付 2007 – 2008: National Institute of Advanced Industrial Science and Technology, セルエンジニアリング研究部門, 主任研究員 Less
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / Biophysics Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Developmental biology / Bio-related chemistry / Chemical biology
Keywords	Principal Investigator 蛋白質工学 / 生物発光 / リプログラミング因子 / 転写因子 / フォールディング / iPS細胞 / 細胞毒性 / 蛋白質導入 / ペプチド / 組織工学 … More / 細胞 / 構造機能相関 / α-ヘリックス / 膜融合 / 受精 / 機能 / 動態 / 核酸の構造 / タンパク質 … More Except Principal Investigator 低分子抗体 / 重鎖・軽鎖組合せ / 食道癌 / 抗体配列進化 / 抗がん抗体 / 抗体レパトア解析 / 抗体スクリーニング / 癌抗体 / 抗体親和性成熟 / 抗体配列進化追跡法 / 構造安定化 / 構造安定性 / 抗体-抗原複合体 / 熱安定性 / 抗原結合能 / 抗体 / JUNO / IZUMO1 / 膜融合 / 卵子 / 精子 / 受精 / バイオ医薬品 / 抗体ー薬物複合体 / 異分子コンジュゲート / シングルドメイン抗体 / イメージング / セルベースアッセイ / ルシフェラーゼ / miRNA / 生体分子計測 Less

Affinity maturation and property changes of single-domain antibodies through repeated immunizations.
- Principal Investigator
  
  Akazawa Yoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Establishment of innovative development scheme of anti-cancer antibody
- Principal Investigator
  
  Matsuda Tomonari
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Kyoto University
Development of visualizing system of microRNA dynamism
- Principal Investigator
  
  Nakajima Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  National Institute of Advanced Industrial Science and Technology
The effect of payload conjugates on VHH antibody
- Principal Investigator
  
  Akazawa Yoko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Elucidation of the molecular mechanism involved in mammalian gamete fusion
- Principal Investigator
  
  Inoue Naokazu
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Fukushima Medical University
Improvement of efficiency of piPS cell developmentPrincipal Investigator
- Principal Investigator
  
  HAGIHARA Yoshihisa
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Molecular analysis of sperm-egg fusion as a model system of cell-cell fusionPrincipal Investigator
- Principal Investigator
  
  HAGIHARA Yoshihisa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2023 2022 2019 2018 2017 2015 2007

All Journal Article Presentation Book

[Book] PHARMSTAGE2023
- Author(s)
  赤澤陽子、萩原義久
- Total Pages
  9
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-20K07009
[Book] タンパク質のアモルファス凝集と溶解性2019
- Author(s)
  赤澤陽子、萩原義久
- Total Pages
  8
- Publisher
  シーエムシー出版
- ISBN
  9784781313979
- Data Source
  KAKENHI-PROJECT-16H03295
[Journal Article] Heat denaturation of the antibody, a multi-domain protein2018
- Author(s)
  Y. Akazawa-Ogawa, H. Nagai, Y. Hagihara
- Journal Title
  
  Biophys. Rev.
  
  Volume: 10 Issue: 2 Pages: 255-258
- DOI
  10.1007/s12551-017-0361-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03295
[Journal Article] Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high throughput sequencing2015
- Author(s)
  Nobuo Miyazaki, Norihiko Kiyose, Yoko Akazawa, Mizuki Takashima, Yosihisa Hagihara, Naokazu Inoue, Tomonari Matsuda, Ryu Ogawa, Seiya Inoue, Yuji Ito
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 157 Issue: 3 Pages: 205-215
- DOI
  10.1093/jb/mvv038
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460151, KAKENHI-PROJECT-26291052
[Journal Article] Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice2015
- Author(s)
  Inoue K, Hagihara Y, Wright D, Suzuki T, Wada I
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 8858-8858
- DOI
  10.1038/ncomms9858
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14462, KAKENHI-PROJECT-26291052, KAKENHI-PROJECT-13J11181
[Presentation] 免疫応答を利用したアルパカ由来シングルドメイン抗体の取得技術2022
- Author(s)
  赤澤陽子, 松田知成, 宮崎誠生, 清瀬紀彦, 伊東祐二, 萩原義久
- Organizer
  日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K20599
[Presentation] 免疫刺激によるシングルドメイン抗体の親和性成熟と物性変化の解析2022
- Author(s)
  赤澤陽子、萩原義久
- Organizer
  第1回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07009
[Presentation] 免疫応答を利用したアルパカ由来シングルドメイン抗体の取得技術2022
- Author(s)
  赤澤陽子、萩原義久
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K07009
[Presentation] ラクダ科動物由来VHH抗体の基盤的な研究開発2017
- Author(s)
  赤澤陽子、萩原義久
- Organizer
  第3回　蛋白質工学研究会ワークショップ　『小分子抗体関連技術』
- Invited
- Data Source
  KAKENHI-PROJECT-16K17939
[Presentation] ラクダ科動物由来VHH抗体の耐熱性の改良2017
- Author(s)
  赤澤陽子、萩原義久
- Organizer
  大阪大学蛋白質研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K17939
[Presentation] 融合因子IZUMO1の構造変化による新規膜融合モデル2015
- Author(s)
  井上直和、萩原義久、Danelle Wright、鈴木貴久、和田郁夫
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-26291052
[Presentation] 受精の膜融合における免疫グロブリンスーパーファミリーIzumoの役割2007
- Author(s)
  井上直和, 萩原義久, 岡部勝
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19570159
[Presentation] 受精の膜融合における免疫グロブリンスーパーファミリーIzumoの役割2007
- Author(s)
  井上直和、萩原義久、岡部勝
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台
- Year and Date
  2007-05-26
- Data Source
  KAKENHI-PROJECT-19570159
[Presentation] 受精膜融合もαヘリックスを使うのかIzumoフラグメントの構造機能解析2007
- Author(s)
  萩原義久、井上直和、平田邦生、浜田大三、上久保裕生、片岡幹雄、山本雅貴、岡部勝
- Organizer
  第30回日本分子生物学会・第80回日本生化学会合同年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19570159
[Presentation] 受精膜融合もαヘリックスを使うのか?Izumo フラグメントの構造機能解析2007
- Author(s)
  萩原義久, 井上直和, 平田邦生, 浜田大三, 上久保裕生,片岡幹雄, 山本雅貴, 岡部勝
- Organizer
  第30回日本分子生物学会・第80回日本生化学会合同年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19570159

1. Akazawa Yoko (50549897)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. INOUE Naokazu (50379096)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. NAKAJIMA Yoshihiro (10291080)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. YAMAMOTO Masaki (60241254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. HIRATA Kunio (20373524)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Matsuda Tomonari (50273488)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. MINE Shouhei (70415751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. WADA Ikuo (40182969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. MIYADO Kenji (60324844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 加藤太一郎 (60423901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 安永茉由 (70712181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大橋真也 (20435556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 武藤学 (40360698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 井倉毅 (70335686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 伊東祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hagihara Yoshihisa 萩原 義久

萩原 義久 ハギハラ ヨシヒサ

Hagihara Yoshihis 萩原 義久

HAGIHARA Yoshihisa 萩原 義久

Research Projects

Research Products

Co-Researchers

Affinity maturation and property changes of single-domain antibodies through repeated immunizations.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of innovative development scheme of anti-cancer antibody

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of visualizing system of microRNA dynamism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of payload conjugates on VHH antibody

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular mechanism involved in mammalian gamete fusion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of efficiency of piPS cell developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of sperm-egg fusion as a model system of cell-cell fusionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] PHARMSTAGE2023

Author(s)

Total Pages

Publisher

Data Source

[Book] タンパク質のアモルファス凝集と溶解性2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Heat denaturation of the antibody, a multi-domain protein2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high throughput sequencing2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] 免疫応答を利用したアルパカ由来シングルドメイン抗体の取得技術2022

Author(s)

Organizer

Data Source

[Presentation] 免疫刺激によるシングルドメイン抗体の親和性成熟と物性変化の解析2022

Hagihara Yoshihisa 萩原義久

萩原義久ハギハラヨシヒサ

Hagihara Yoshihis 萩原義久

HAGIHARA Yoshihisa 萩原義久