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Shinkura Reiko  新藏 礼子

ORCIDConnect your ORCID iD *help
… Alternative Names

REIKO Shinkura  新藏 礼子

新蔵 礼子  シンクラ レイコ

SHINKURA Reiko  新藏 礼子

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Researcher Number 50362471
Other IDs
Affiliation (Current) 2019: 東京大学, 定量生命科学研究所, 教授
Affiliation (based on the past Project Information) *help 2018 – 2019: 東京大学, 定量生命科学研究所, 教授
2017: 東京大学, 分子細胞生物学研究所, 教授
2016: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授
2013 – 2015: 長浜バイオ大学, バイオサイエンス学部, 教授
2010: Kyoto University, バイオサイエンス学部, 教授 … More
2009: 長浜バイオ大学, バイオサイエンス部, 教授
2007 – 2009: 京都大学, 医学研究科, 准教授
2005 – 2006: 京都大学, 医学研究科, 講師
2005: Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 寄付講座講師
2004: Kyoto University, Graduate School of Medicine, Research Assistant, 医学研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Immunology / Biological Sciences / General medical chemistry / Bacteriology (including mycology) / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Except Principal Investigator
Biological Sciences / Immunology / Basic Section 53040:Nephrology-related / Basic Section 57020:Oral pathobiological science-related
Keywords
Principal Investigator
抗体 / AID / クラススイッチ / 体細胞突然変異 / B細胞免疫応答 / DNA組み換え / DNA組みかえ / 遺伝子組み換え / DNA修復 / antibody … More / class switch recombination / somatic hypermutation / humoral immune response / 粘膜免疫 / 腸内細菌 / 腸内細菌叢 / IgA抗体 / 腸管免疫 / アレルギー … More
Except Principal Investigator
Notch / RBP-J / Mint / クラススイッチ / 体細胞突然変異 / RNA編集 / ウラシルDNAグリコシラーゼ / 免疫沈降法 / マイクロアレイ法 / 免役学 / 抗体 / ゲノム / 癌 / 細胞運命決定 / 細胞分化 / リンパ球分化 / 遺伝子欠損マウス / Cell fate decision / Cell differentiation / Lymphocyte development / Knockout mouse / 粘膜免疫 / 腎臓病 / 加齢性病態 / 認知機能低下 / 口腔内細菌 / IgA / 歯周病 Less
  • Research Projects

    (10 results)
  • Research Products

    (62 results)
  • Co-Researchers

    (23 People)
  •  The role of abnormal mucosal immunity in renal senescenceOngoing

    • Principal Investigator
      成田 一衛
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Niigata University
  •  The regulation of oral microbiota by IgAOngoing

    • Principal Investigator
      孫 安生
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      The University of Tokyo
  •  特異的IgAクラススイッチ誘導による粘膜バリア増強とアレルギーの新規治療Principal InvestigatorOngoing

    • Principal Investigator
      新藏 礼子
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      The University of Tokyo
  •  Mechanism of intestinal midrobiota regulation by intestinal IgAPrincipal Investigator

    • Principal Investigator
      Shinkura Reiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bacteriology (including mycology)
    • Research Institution
      The University of Tokyo
      Nara Institute of Science and Technology
      Nagahama Institute of Bio-Science and Technology
  •  Identification of co-factors specific for somatic hypermutation of immunoglobulin genesPrincipal Investigator

    • Principal Investigator
      REIKO Shinkura
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Nagahama Institute of Bio-Science and Technology
  •  Identification of novel essential factors responsible for class switch recombination of immunoglobulin genes.Principal Investigator

    • Principal Investigator
      SHINKURA Reiko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Kyoto University
  •  AID-dependent genetic alteration mechanism to generate antigen-specific antibodies

    • Principal Investigator
      HONJO Tasuku
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  抗体遺伝子のクラススイッチおよび体細胞突然変異の機構の解明Principal Investigator

    • Principal Investigator
      新蔵 礼子
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Regulation of lymphocyte development by Notch/RBP-J signaling

    • Principal Investigator
      HONJO Tasuku
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      Kyoto University
  •  Molecular mechanism of class switch recombination and somatic hypermutation.Principal Investigator

    • Principal Investigator
      SHINKURA Reiko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Kyoto University

All 2018 2017 2016 2015 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

  • [Book] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Vol.942007

    • Author(s)
      Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
    • Publisher
      ELSEVIER, Adv. Immunol.
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] 腸管IgA抗体による腸内細菌制御機構2018

    • Author(s)
      新藏礼子
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 46-50

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] Intestinal IgA as a modulator of the gut microbiota2017

    • Author(s)
      Okai S, Usui F, Ohta M, Mori H, Kurokawa K, Matsumoto S, Kato T, Miyauchi E, Ohno H, Shinkura R
    • Journal Title

      Gut Microbes

      Volume: 6 Pages: 486-492

    • DOI
      10.1080/19490976.2017.1310357
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18711, KAKENHI-PROJECT-15H04732
  • [Journal Article] Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes2017

    • Author(s)
      McDonald Gabrielle、Medina Carlos O.、Pilichowska Monika、Kearney John F.、Shinkura Reiko、Selsing Erik、Wortis Henry H.、Honjo Tasuku、Imanishi-Kari Thereza
    • Journal Title

      Frontiers in Immunology

      Volume: 8 Pages: 1-15

    • DOI
      10.3389/fimmu.2017.01094
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] 腸管IgA抗体による腸内細菌及び炎症性疾患の制御機構2017

    • Author(s)
      岡井晋作、新藏礼子
    • Journal Title

      感染・炎症・免疫

      Volume: 47 Pages: 73-75

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] 悪玉腸内細菌増殖を抑えるIgA抗体2017

    • Author(s)
      新藏礼子、岡井晋作、臼井文人
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 75 Pages: 142-143

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] 腸管IgA抗体による腸内細菌制御のメカニズム-IgA抗体は腸管内でなにをしている?2017

    • Author(s)
      臼井文人、新藏礼子
    • Journal Title

      化学と生物

      Volume: 55 Pages: 596-601

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] 腸管IgA抗体による腸内細菌制御2017

    • Author(s)
      岡井晋作,新藏礼子
    • Journal Title

      実験医学

      Volume: 42 Pages: 42-47

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] Decreased Taxon-Specific IgA Response in Relation to the Changes of Gut Microbiota Composition in the Elderly2017

    • Author(s)
      Sugahara Hirosuke、Okai Shinsaku、Odamaki Toshitaka、Wong Chyn B.、Kato Kumiko、Mitsuyama Eri、Xiao Jin-Zhong、Shinkura Reiko
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 1-8

    • DOI
      10.3389/fmicb.2017.01757
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] 腸内常在細菌に対するモノクローナルIgAの応答2017

    • Author(s)
      新藏礼子
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 67 Pages: 612-616

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.2016

    • Author(s)
      Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R.
    • Journal Title

      Nat Microbiol.

      Volume: 1 Pages: 16103-16103

    • DOI
      10.1038/nmicrobiol.2016.103
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-25112006, KAKENHI-PLANNED-26106004, KAKENHI-PROJECT-15H04732, KAKENHI-PROJECT-16H05207, KAKENHI-PROJECT-16J11295, KAKENHI-PROJECT-16K18711, KAKENHI-ORGANIZER-25112001
  • [Journal Article] 高親和性モノクローナルIgAはマウスの腸内細菌叢を改善し大腸炎を予防する2016

    • Author(s)
      岡井晋作、新藏礼子
    • Journal Title

      実験医学

      Volume: 34(19) Pages: 3185-3188

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] ’’微生物と人類の共存’’をゲノムの視点から2016

    • Author(s)
      新藏礼子、他共著
    • Journal Title

      生物の科学

      Volume: 71(1) Pages: 77-85

    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] IgA抗体による腸内細菌の制御機構2015

    • Author(s)
      新藏 礼子
    • Journal Title

      医学のあゆみ

      Volume: 増刊号 Pages: 375-380

    • Open Access
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Journal Article] Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense.2011

    • Author(s)
      Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T.
    • Journal Title

      Nature Immunology

      Volume: 12 Pages: 264-270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense.2011

    • Author(s)
      Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T.
    • Journal Title

      Nature Immunology 12

      Pages: 264-270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] 免疫グロブリンの体細胞突然変異・クラススイッチとAIDおよびその関連分子2010

    • Author(s)
      新蔵礼子
    • Journal Title

      臨床免疫・アレルギー科 54

      Pages: 72-79

    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010

    • Author(s)
      Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T.
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1018-1024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.2010

    • Author(s)
      Tran, T., Nakata, M., Suzuki, K., Begum, N.A., Shinkura, R., Fagarasan, S., Honjo, T., Nagaoka, H.
    • Journal Title

      Nature Immunol. 11

      Pages: 148-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010

    • Author(s)
      Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T.
    • Journal Title

      Leukemia 24

      Pages: 1018-1024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] 免疫グロブリンの体細胞突然変異・クラススイッチとAIDおよびその関連分子2010

    • Author(s)
      新蔵礼子
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 72-79

    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010

    • Author(s)
      Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T., Kitamura, T.
    • Journal Title

      Leukemia 24

      Pages: 1018-1024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alterlation and DNA cleavage for class switch recombination.2009

    • Author(s)
      Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T.
    • Journal Title

      PNAS 106

      Pages: 22375-22380

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] Molecular mechanism for generation of antibody memory.2009

    • Author(s)
      Shivarov V, Shinkura R, Doi T, BegumNA, Nagaoka H, Okazaki IM, Ito S, Nonaka T, Kinoshita K, Honjo T.
    • Journal Title

      Philos Trans R Soc Lond B Bio Sci 364

      Pages: 569-575

    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.2009

    • Author(s)
      Doi T, Kato L, Ito S, Shinkura R, Wei M, Nagaoka Hm, Wang J, Honjoj T.
    • Journal Title

      PNAS 106

      Pages: 2758-2763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobilin genes.2009

    • Author(s)
      Sabouri, Z., Okazaki, I., Shinkura, R., Begum, N.A., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y., Honjo, T.
    • Journal Title

      Int.Immunol. 21

      Pages: 947-955

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.2009

    • Author(s)
      Doi, T., Kato, L., Ito, S., Shinkura, R., Wei, M., Nagaoka, H., Wang, J., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 2758-2763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.2009

    • Author(s)
      Tran TH, Nakata N, Begum NA, Shinkura R, Honjo T, Nagaoka H.
    • Journal Title

      Nature Immunology 11

      Pages: 148-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.2009

    • Author(s)
      Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y , Honjo T.
    • Journal Title

      International Immunology 21

      Pages: 947-955

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009

    • Author(s)
      Kobayashi, M., Aida, M., Nagaoka, H., Begum, N.A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I., Shinkura R., Muramatsu, M., Kinoshita, K., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 22375-22380

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008

    • Author(s)
      Shivarov, V., Shinkura, R., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 105

      Pages: 15866-15871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008

    • Author(s)
      Shivarov, V, Shinkura R, Honjo T.
    • Journal Title

      Proc Natl Acad Sci U S A. 105

      Pages: 15866-15871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008

    • Author(s)
      Shivarov V, Shinkura R, Honjo T.
    • Journal Title

      PNAS 105

      Pages: 15866-15871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Journal Article] Regulation of AID function in vivo.2007

    • Author(s)
      Shinkura, R., et al.
    • Journal Title

      Advances in Experimental Medicine and Biology 596

      Pages: 71-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.2007

    • Author(s)
      Begum, N.A., Izumi, N., Nishikori, M., Nagaoka, H., Shinkura, R., Honjo, T.
    • Journal Title

      J.Biol.Chem. 282

      Pages: 731-742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] Regulation of AID function in vivo.2007

    • Author(s)
      Shinkura, R.et al.
    • Journal Title

      Advances in Experimental Medicine and Biology 596

      Pages: 71-84

    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.2007

    • Author(s)
      Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
    • Journal Title

      Adv.Immunol. 94

      Pages: 1-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] AID to overcome the limitations of genomic information.2005

    • Author(s)
      Honjo, T., Nagaoka, H., Shinkura, R., Muramatsu, M.
    • Journal Title

      Nature Immunol. 6

      Pages: 655-661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17002015
  • [Journal Article] Separate domains of AID are required for somatic hypermutation and class-switch recombination.2004

    • Author(s)
      Shinkura, R. et al.
    • Journal Title

      Nature Immunology 5

      Pages: 707-712

    • Data Source
      KAKENHI-PROJECT-16043228
  • [Journal Article] Separate domains of AID are required for somatic hypermutation and class switch recombination.2004

    • Author(s)
      Shinkura R., et al.
    • Journal Title

      Nature Immunology

      Volume: 5 Pages: 707-712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16043228
  • [Journal Article] Separate domains of AID are required for somatic hypermutation and class-switch recombination.2004

    • Author(s)
      Shinkura, R. et al.
    • Journal Title

      Nature Immunology 5

      Pages: 707-712

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590401
  • [Presentation] 腸内細菌叢改善のためのIgA抗体医薬2018

    • Author(s)
      新藏 礼子
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] 腸管IgA抗体による常在腸内細菌制御機構の解明と応用2018

    • Author(s)
      新藏 礼子
    • Organizer
      千里ライフサイエンスセミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] Intestinal IgA as a modulator of the gut microbiota2017

    • Author(s)
      Reiko Shinkura
    • Organizer
      1st International Seminar on Biotechnology
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] High-affinity intestinal IgA as a modulator of the gut microbiota.2017

    • Author(s)
      Reiko Shinkura
    • Organizer
      Cytokine 2017
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] 腸管IgA抗体による常在腸内細菌叢制御2017

    • Author(s)
      新藏 礼子
    • Organizer
      第27回 日本サイトメトリー学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] Intestinal IgA as a modulator of the gut microbiota2017

    • Author(s)
      Reiko Shinkura
    • Organizer
      ゲノム先進シンポジウム
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2017-01-10
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] Intestinal IgA as a modulator of the gut microbiota.2017

    • Author(s)
      Reiko Shinkura
    • Organizer
      The 16th Awaji International Forum on Infection and Immunity
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] 腸管IgA抗体による腸内細菌制御2017

    • Author(s)
      新藏 礼子
    • Organizer
      第35回サイトプロテクション研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] IgA抗体による腸内細菌制御ー炎症性腸疾患新規治療薬候補としてー2015

    • Author(s)
      新藏 礼子
    • Organizer
      第8回鹿児島FD・IBS研究会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2015-07-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] High-affinity, poly-reactive IgA is required for gut homeostatic maintenance to prevent colitis in mice.2015

    • Author(s)
      岡井 晋作、新藏 礼子、他
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] 腸管IgA抗体は多種類の腸内細菌の特異的なアミノ酸配列を認識している。2015

    • Author(s)
      臼井 文人、新藏 礼子、他
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会、合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] 腸炎モデルマウスに対する腸管IgA抗体の作用機序の解明2015

    • Author(s)
      岡井 晋作、新藏 礼子、他
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会、合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] Monoclonal intestinal IgAs are poly-reactive but recognize a specific amino acid sequence of protein expressed by multiple bacteria.2015

    • Author(s)
      臼井 文人、新藏 礼子、他
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-15H04732
  • [Presentation] Knock-in mice carrying a somatic hypermutation-defective AICDA mutation have compromised mucosal defense and impaired gut homeostasis.2010

    • Author(s)
      Shinkura R, Wei M, Honjo T.
    • Organizer
      14^<th> International Congress of Immunology.
    • Place of Presentation
      Kobe, Japan.
    • Year and Date
      2010-08-26
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Presentation] Knock-in mice carrying a somatic hypermutation-defective AICDA mutation have compromised mucosal defense and impaired gut homeostasis.2010

    • Author(s)
      Shinkura R, Wei M, Honjo T.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-08-26
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Presentation] Knock-in mice carrying a somatic hypermutation-defective Aicda mutation have impaired gut homeostasis and compromised mucosal defense.2010

    • Author(s)
      Shinkura R., et al.
    • Organizer
      International Congress of Immunology
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-08-22
    • Data Source
      KAKENHI-PROJECT-16043228
  • [Presentation] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008

    • Author(s)
      Shinkura R, Shivarov V, Honjo T.
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Presentation] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008

    • Author(s)
      Shinkura R, Shivarov V, Honjo T.
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20590490
  • [Presentation] AID domains defined from functional analyses using AID mutants.2007

    • Author(s)
      Shinkura R.
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Arizona, USA
    • Year and Date
      2007-06-30
    • Invited
    • Data Source
      KAKENHI-PROJECT-16043228
  • [Presentation] N-terminal region of activation-induced cytidine deaminase distinguishes downstream events for somatic hypermutation from gene conversion.2006

    • Author(s)
      Shinkura R.
    • Organizer
      20^<th> IUBMB International Congress of Biotechnology and Molecular Biology and 11^<th> FAOBMB
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2006-06-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-16043228
  • [Presentation] Separate domains of AID are required for somatic hypermutation and class-switch recombination.2004

    • Author(s)
      Shinkura R., et al.
    • Organizer
      International Congress of Immunology
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2004-07-31
    • Data Source
      KAKENHI-PROJECT-16043228
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    # of Collaborated Products: 10 results
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  • 19.  金子 佳賢 (80444157)
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  • 20.  YAMADA Keisuke
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  • 21.  NAKAMURA Toshinobu
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    # of Collaborated Products: 1 results
  • 22.  大野 博司
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  • 23.  宮内 栄治
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