Shinkura Reiko 新藏礼子

… Alternative Names

Researcher Number	50362471
Other IDs	https://orcid.org/0000-0002-7976-9933
Affiliation (Current)	2021: 東京大学, 定量生命科学研究所, 教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 東京大学, 定量生命科学研究所, 教授 2017: 東京大学, 分子細胞生物学研究所, 教授 2016: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 2013 – 2015: 長浜バイオ大学, バイオサイエンス学部, 教授 2010: Kyoto University, バイオサイエンス学部, 教授 … More
Review Section/Research Field	Principal Investigator Immunology / Biological Sciences / General medical chemistry / Bacteriology (including mycology) / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Medium-sized Section 49:Pathology, infection/immunology, and related fields Except Principal Investigator Biological Sciences / Immunology / Basic Section 57020:Oral pathobiological science-related / Basic Section 53040:Nephrology-related
Keywords	Principal Investigator 抗体 / AID / クラススイッチ / 体細胞突然変異 / B細胞免疫応答 / IgA抗体 / アレルギー / DNA組み換え / DNA組みかえ / 遺伝子組み換え … More Except Principal Investigator Notch / RBP-J / Mint / クラススイッチ / 体細胞突然変異 / RNA編集 / ウラシルDNAグリコシラーゼ / 免疫沈降法 / マイクロアレイ法 / 免役学 / 抗体 / ゲノム / 癌 / 細胞運命決定 / 細胞分化 / リンパ球分化 / 遺伝子欠損マウス / Cell fate decision / Cell differentiation / Lymphocyte development / Knockout mouse / 口腔内細菌 / IgA / 歯周病 / 腎性老化 / 粘膜免疫 / IgA腎症 / マイクロバイオーム / サルコペニア / CKD-MBD / 口蓋扁桃 / 腎臓病 / 加齢性病態 / 認知機能低下 Less

A novel treatment for allergy by selective IgA class switchingPrincipal InvestigatorOngoing
- Principal Investigator
  
  新藏礼子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
The regulation of oral microbiota by IgAOngoing
- Principal Investigator
  
  孫安生
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  The University of Tokyo
The role of abnormal mucosal immunity in renal senescenceOngoing
- Principal Investigator
  
  成田一衛
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
A novel treatment of allergy by mucosal barrier enhancement through selective IgA class switchingPrincipal Investigator
- Principal Investigator
  
  Shinkura Reiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
Mechanism of intestinal midrobiota regulation by intestinal IgAPrincipal Investigator
- Principal Investigator
  
  Shinkura Reiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  The University of Tokyo
  Nara Institute of Science and Technology
  Nagahama Institute of Bio-Science and Technology
Identification of co-factors specific for somatic hypermutation of immunoglobulin genesPrincipal Investigator
- Principal Investigator
  
  REIKO Shinkura
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Identification of novel essential factors responsible for class switch recombination of immunoglobulin genes.Principal Investigator
- Principal Investigator
  
  SHINKURA Reiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
抗体遺伝子のクラススイッチおよび体細胞突然変異の機構の解明Principal Investigator
- Principal Investigator
  
  新蔵礼子
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Regulation of lymphocyte development by Notch/RBP-J signaling
- Principal Investigator
  
  HONJO Tasuku
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Molecular mechanism of class switch recombination and somatic hypermutation.Principal Investigator
- Principal Investigator
  
  SHINKURA Reiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2019 2018 2017 2016 2015 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book Patent

[Book] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Vol.942007
- Author(s)
  Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
- Publisher
  ELSEVIER, Adv. Immunol.
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease2019
- Author(s)
  Toba Koji、Hosojima Michihiro、Kabasawa Hideyuki、Kuwahara Shoji、Murayama Toshiko、Yamamoto-Kabasawa Keiko、Kaseda Ryohei、Wada Eri、Watanabe Reiko、Tanabe Naohito、Suzuki Yoshiki、Narita Ichiei、Saito Akihiko
- Journal Title
  
  BMC Nephrology
  
  Volume: 20 Pages: 421-421
- DOI
  10.1186/s12882-019-1591-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03674
[Journal Article] 腸管IgA抗体による腸内細菌制御機構2018
- Author(s)
  新藏礼子
- Journal Title
  
  医学のあゆみ
  
  Volume: 264 Pages: 46-50
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] 腸管IgA抗体による腸内細菌制御2017
- Author(s)
  岡井晋作，新藏礼子
- Journal Title
  
  実験医学
  
  Volume: 42 Pages: 42-47
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes2017
- Author(s)
  McDonald Gabrielle、Medina Carlos O.、Pilichowska Monika、Kearney John F.、Shinkura Reiko、Selsing Erik、Wortis Henry H.、Honjo Tasuku、Imanishi-Kari Thereza
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 8 Pages: 1-15
- DOI
  10.3389/fimmu.2017.01094
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] Intestinal IgA as a modulator of the gut microbiota2017
- Author(s)
  Okai S, Usui F, Ohta M, Mori H, Kurokawa K, Matsumoto S, Kato T, Miyauchi E, Ohno H, Shinkura R
- Journal Title
  
  Gut Microbes
  
  Volume: 6 Pages: 486-492
- DOI
  10.1080/19490976.2017.1310357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18711, KAKENHI-PROJECT-15H04732
[Journal Article] Decreased Taxon-Specific IgA Response in Relation to the Changes of Gut Microbiota Composition in the Elderly2017
- Author(s)
  Sugahara Hirosuke、Okai Shinsaku、Odamaki Toshitaka、Wong Chyn B.、Kato Kumiko、Mitsuyama Eri、Xiao Jin-Zhong、Shinkura Reiko
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 8 Pages: 1-8
- DOI
  10.3389/fmicb.2017.01757
- NAID
  120006354237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] 腸管IgA抗体による腸内細菌制御のメカニズム-IgA抗体は腸管内でなにをしている？2017
- Author(s)
  臼井文人、新藏礼子
- Journal Title
  
  化学と生物
  
  Volume: 55 Pages: 596-601
- NAID
  130007437196
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] 腸管IgA抗体による腸内細菌及び炎症性疾患の制御機構2017
- Author(s)
  岡井晋作、新藏礼子
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 47 Pages: 73-75
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] 腸内常在細菌に対するモノクローナルIgAの応答2017
- Author(s)
  新藏礼子
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 67 Pages: 612-616
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] 悪玉腸内細菌増殖を抑えるIgA抗体2017
- Author(s)
  新藏礼子、岡井晋作、臼井文人
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 75 Pages: 142-143
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in　mice.2016
- Author(s)
  Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R.
- Journal Title
  
  Nat Microbiol.
  
  Volume: 1 Pages: 16103-16103
- DOI
  10.1038/nmicrobiol.2016.103
- NAID
  120005818448
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-25112006, KAKENHI-PLANNED-26106004, KAKENHI-PROJECT-15H04732, KAKENHI-PROJECT-16H05207, KAKENHI-PROJECT-16J11295, KAKENHI-PROJECT-16K18711, KAKENHI-ORGANIZER-25112001
[Journal Article] 高親和性モノクローナルIgAはマウスの腸内細菌叢を改善し大腸炎を予防する2016
- Author(s)
  岡井晋作、新藏礼子
- Journal Title
  
  実験医学
  
  Volume: 34(19) Pages: 3185-3188
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] ’’微生物と人類の共存’’をゲノムの視点から2016
- Author(s)
  新藏礼子、他共著
- Journal Title
  
  生物の科学
  
  Volume: 71(1) Pages: 77-85
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] IgA抗体による腸内細菌の制御機構2015
- Author(s)
  新藏　礼子
- Journal Title
  
  医学のあゆみ
  
  Volume: 増刊号 Pages: 375-380
- Open Access
- Data Source
  KAKENHI-PROJECT-15H04732
[Journal Article] Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense.2011
- Author(s)
  Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T.
- Journal Title
  
  Nature Immunology 12
  
  Pages: 264-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense.2011
- Author(s)
  Wei M, Shinkura R, Doi Y, Maruya M, Fagarasan S, Honjo T.
- Journal Title
  
  Nature Immunology
  
  Volume: 12 Pages: 264-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010
- Author(s)
  Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T.
- Journal Title
  
  Leukemia
  
  Volume: 24 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.2010
- Author(s)
  Tran, T., Nakata, M., Suzuki, K., Begum, N.A., Shinkura, R., Fagarasan, S., Honjo, T., Nagaoka, H.
- Journal Title
  
  Nature Immunol. 11
  
  Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] 免疫グロブリンの体細胞突然変異・クラススイッチとAIDおよびその関連分子2010
- Author(s)
  新蔵礼子
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 54 Pages: 72-79
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010
- Author(s)
  Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T.
- Journal Title
  
  Leukemia 24
  
  Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model.2010
- Author(s)
  Komeno, Y., Kitaura, J., Watanabe-Okochi, N., Kato, N., Oki, T., Nakahara, F., Harada, Y., Harada, H., Shinkura, R., Nagaoka, H., Hayashi, Y., Honjo, T., Kitamura, T.
- Journal Title
  
  Leukemia 24
  
  Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] 免疫グロブリンの体細胞突然変異・クラススイッチとAIDおよびその関連分子2010
- Author(s)
  新蔵礼子
- Journal Title
  
  臨床免疫・アレルギー科 54
  
  Pages: 72-79
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.2009
- Author(s)
  Tran TH, Nakata N, Begum NA, Shinkura R, Honjo T, Nagaoka H.
- Journal Title
  
  Nature Immunology 11
  
  Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobilin genes.2009
- Author(s)
  Sabouri, Z., Okazaki, I., Shinkura, R., Begum, N.A., Nagaoka, H., Tsuchimoto, D., Nakabeppu, Y., Honjo, T.
- Journal Title
  
  Int.Immunol. 21
  
  Pages: 947-955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.2009
- Author(s)
  Doi T, Kato L, Ito S, Shinkura R, Wei M, Nagaoka Hm, Wang J, Honjoj T.
- Journal Title
  
  PNAS 106
  
  Pages: 2758-2763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.2009
- Author(s)
  Kobayashi, M., Aida, M., Nagaoka, H., Begum, N.A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I., Shinkura R., Muramatsu, M., Kinoshita, K., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 22375-22380
- NAID
  120001749564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] AID-induced decrease in topoisomerase 1 induces DNA structural alterlation and DNA cleavage for class switch recombination.2009
- Author(s)
  Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T.
- Journal Title
  
  PNAS 106
  
  Pages: 22375-22380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.2009
- Author(s)
  Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y , Honjo T.
- Journal Title
  
  International Immunology 21
  
  Pages: 947-955
- NAID
  10025387710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] Molecular mechanism for generation of antibody memory.2009
- Author(s)
  Shivarov V, Shinkura R, Doi T, BegumNA, Nagaoka H, Okazaki IM, Ito S, Nonaka T, Kinoshita K, Honjo T.
- Journal Title
  
  Philos Trans R Soc Lond B Bio Sci 364
  
  Pages: 569-575
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.2009
- Author(s)
  Doi, T., Kato, L., Ito, S., Shinkura, R., Wei, M., Nagaoka, H., Wang, J., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 2758-2763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008
- Author(s)
  Shivarov, V., Shinkura, R., Honjo, T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 105
  
  Pages: 15866-15871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008
- Author(s)
  Shivarov V, Shinkura R, Honjo T.
- Journal Title
  
  PNAS 105
  
  Pages: 15866-15871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008
- Author(s)
  Shivarov, V, Shinkura R, Honjo T.
- Journal Title
  
  Proc Natl Acad Sci U S A. 105
  
  Pages: 15866-15871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590490
[Journal Article] Regulation of AID function in vivo.2007
- Author(s)
  Shinkura, R., et al.
- Journal Title
  
  Advances in Experimental Medicine and Biology 596
  
  Pages: 71-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Regulation of AID function in vivo.2007
- Author(s)
  Shinkura, R.et al.
- Journal Title
  
  Advances in Experimental Medicine and Biology 596
  
  Pages: 71-84
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.2007
- Author(s)
  Begum, N.A., Izumi, N., Nishikori, M., Nagaoka, H., Shinkura, R., Honjo, T.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 731-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.2007
- Author(s)
  Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N.A., Honjo, T.
- Journal Title
  
  Adv.Immunol. 94
  
  Pages: 1-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] AID to overcome the limitations of genomic information.2005
- Author(s)
  Honjo, T., Nagaoka, H., Shinkura, R., Muramatsu, M.
- Journal Title
  
  Nature Immunol. 6
  
  Pages: 655-661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17002015
[Journal Article] Separate domains of AID are required for somatic hypermutation and class switch recombination.2004
- Author(s)
  Shinkura R., et al.
- Journal Title
  
  Nature Immunology
  
  Volume: 5 Pages: 707-712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16043228
[Journal Article] Separate domains of AID are required for somatic hypermutation and class-switch recombination.2004
- Author(s)
  Shinkura, R. et al.
- Journal Title
  
  Nature Immunology 5
  
  Pages: 707-712
- Data Source
  KAKENHI-PROJECT-16043228
[Journal Article] Separate domains of AID are required for somatic hypermutation and class-switch recombination.2004
- Author(s)
  Shinkura, R. et al.
- Journal Title
  
  Nature Immunology 5
  
  Pages: 707-712
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590401
[Patent] ペプチド2015
- Inventor(s)
  新藏礼子、岡井晋作、臼井文人
- Industrial Property Rights Holder
  新藏礼子、岡井晋作、臼井文人
- Industrial Property Rights Type
  特許
- Filing Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] 1.The selective induction of IgA production by PKC activators.2018
- Author(s)
  Aoi Son, Hitomi, Sakatani, Reiko Shinkura.
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K19559
[Presentation] 腸内細菌叢改善のためのIgA抗体医薬2018
- Author(s)
  新藏　礼子
- Organizer
  日本薬学会第１３８年会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] 腸管IgA抗体による常在腸内細菌制御機構の解明と応用2018
- Author(s)
  新藏　礼子
- Organizer
  千里ライフサイエンスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] The specific induction of IgA production by PKC activators.2018
- Author(s)
  Hitomi Sakatani, Aoi Son, Reiko Shinkura.
- Organizer
  The 41th Annual Meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-18K19559
[Presentation] 腸管IgA抗体による腸内細菌制御2017
- Author(s)
  新藏　礼子
- Organizer
  第35回サイトプロテクション研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] Intestinal IgA as a modulator of the gut microbiota2017
- Author(s)
  Reiko Shinkura
- Organizer
  ゲノム先進シンポジウム
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2017-01-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] Intestinal IgA as a modulator of the gut microbiota2017
- Author(s)
  Reiko Shinkura
- Organizer
  1st International Seminar on Biotechnology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] 腸管IgA抗体による常在腸内細菌叢制御2017
- Author(s)
  新藏　礼子
- Organizer
  第27回　日本サイトメトリー学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] High-affinity intestinal IgA as a modulator of the gut microbiota.2017
- Author(s)
  Reiko Shinkura
- Organizer
  Cytokine 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] Intestinal IgA as a modulator of the gut microbiota.2017
- Author(s)
  Reiko Shinkura
- Organizer
  The 16th Awaji International Forum on Infection and Immunity
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] High-affinity, poly-reactive IgA is required for gut homeostatic maintenance to prevent colitis in mice.2015
- Author(s)
  岡井　晋作、新藏　礼子、他
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] 腸管IgA抗体は多種類の腸内細菌の特異的なアミノ酸配列を認識している。2015
- Author(s)
  臼井　文人、新藏　礼子、他
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会、合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] IgA抗体による腸内細菌制御ー炎症性腸疾患新規治療薬候補としてー2015
- Author(s)
  新藏　礼子
- Organizer
  第８回鹿児島FD・IBS研究会
- Place of Presentation
  鹿児島大学
- Year and Date
  2015-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] 腸炎モデルマウスに対する腸管IgA抗体の作用機序の解明2015
- Author(s)
  岡井　晋作、新藏　礼子、他
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会、合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] Monoclonal intestinal IgAs are poly-reactive but recognize a specific amino acid sequence of protein expressed by multiple bacteria.2015
- Author(s)
  臼井　文人、新藏　礼子、他
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15H04732
[Presentation] Knock-in mice carrying a somatic hypermutation-defective AICDA mutation have compromised mucosal defense and impaired gut homeostasis.2010
- Author(s)
  Shinkura R, Wei M, Honjo T.
- Organizer
  14^<th> International Congress of Immunology.
- Place of Presentation
  Kobe, Japan.
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-20590490
[Presentation] Knock-in mice carrying a somatic hypermutation-defective Aicda mutation have impaired gut homeostasis and compromised mucosal defense.2010
- Author(s)
  Shinkura R., et al.
- Organizer
  International Congress of Immunology
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-16043228
[Presentation] Knock-in mice carrying a somatic hypermutation-defective AICDA mutation have compromised mucosal defense and impaired gut homeostasis.2010
- Author(s)
  Shinkura R, Wei M, Honjo T.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-20590490
[Presentation] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008
- Author(s)
  Shinkura R, Shivarov V, Honjo T.
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20590490
[Presentation] Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.2008
- Author(s)
  Shinkura R, Shivarov V, Honjo T.
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20590490
[Presentation] AID domains defined from functional analyses using AID mutants.2007
- Author(s)
  Shinkura R.
- Organizer
  FASEB Summer Research Conferences
- Place of Presentation
  Arizona, USA
- Year and Date
  2007-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-16043228
[Presentation] N-terminal region of activation-induced cytidine deaminase distinguishes downstream events for somatic hypermutation from gene conversion.2006
- Author(s)
  Shinkura R.
- Organizer
  20^<th> IUBMB International Congress of Biotechnology and Molecular Biology and 11^<th> FAOBMB
- Place of Presentation
  京都国際会議場
- Year and Date
  2006-06-22
- Invited
- Data Source
  KAKENHI-PROJECT-16043228
[Presentation] Separate domains of AID are required for somatic hypermutation and class-switch recombination.2004
- Author(s)
  Shinkura R., et al.
- Organizer
  International Congress of Immunology
- Place of Presentation
  Montreal, Canada
- Year and Date
  2004-07-31
- Data Source
  KAKENHI-PROJECT-16043228

1. HONJO Tasuku (80090504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. BEGUM Nasim (80362507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 孫安生 (30447924)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 森田直樹 (80845107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NISHIKORI Momoko (60378635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. NAGAOKA Hitoshi (20270647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. CHON Il-Mi (50452339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. KOBAYASHI Maki (20400690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. DOI Tomomitsu (70437218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. YABE Daisuke (60378643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUROKAWA Ken (20343246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. MORI Hiroshi (40610837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 磯谷綾子 (20444523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 成田一衛 (20272817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 後藤眞 (00463969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 若杉三奈子 (10584782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 忰田亮平 (20737697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 葭原明弘 (50201033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山本卓 (70444156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 金子佳賢 (80444157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 近藤輝幸 (20211914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YAMADA Keisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAMURA Toshinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 宮内栄治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 大野博司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinkura Reiko 新藏 礼子

REIKO Shinkura 新藏 礼子

新蔵 礼子 シンクラ レイコ

SHINKURA Reiko 新藏 礼子

Research Projects

Research Products

Co-Researchers

A novel treatment for allergy by selective IgA class switchingPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

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The regulation of oral microbiota by IgAOngoing

Principal Investigator

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The role of abnormal mucosal immunity in renal senescenceOngoing

Principal Investigator

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A novel treatment of allergy by mucosal barrier enhancement through selective IgA class switchingPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

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Mechanism of intestinal midrobiota regulation by intestinal IgAPrincipal Investigator

Principal Investigator

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Identification of co-factors specific for somatic hypermutation of immunoglobulin genesPrincipal Investigator

Principal Investigator

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Identification of novel essential factors responsible for class switch recombination of immunoglobulin genes.Principal Investigator

Principal Investigator

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AID-dependent genetic alteration mechanism to generate antigen-specific antibodies

Principal Investigator

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抗体遺伝子のクラススイッチおよび体細胞突然変異の機構の解明Principal Investigator

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Regulation of lymphocyte development by Notch/RBP-J signaling

Principal Investigator

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Molecular mechanism of class switch recombination and somatic hypermutation.Principal Investigator

Principal Investigator

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[Book] Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Vol.942007

Author(s)

Publisher

Data Source

[Journal Article] Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease2019

Author(s)

Journal Title

Shinkura Reiko 新藏礼子

REIKO Shinkura 新藏礼子

新蔵礼子シンクラレイコ

SHINKURA Reiko 新藏礼子

[Journal Article] High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in　mice.2016