Yamamoto Takeshi 山本健

… Alternative Names

YAMAMOTO Takeshi 山本健

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Researcher Number	50363122
Other IDs
Affiliation (Current)	2025: 山口大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 山口大学, 大学院医学系研究科, 教授 2016: 山口大学, 医学(系)研究科(研究院), 教授 2015: 山口大学, 大学院医学系研究科, 准教授 2013 – 2015: 山口大学, 医学(系)研究科(研究院), 准教授 2013: 山口大学, 大学院医学系研究科, 准教授 … More 2012: 山口大学, 医学部附属病院, 講師 2011: 山口大学, 医学(系)研究科(研究院), 助教 2007 – 2011: Yamaguchi University, Graduate School of Medicine, Assistant Professor 2006: 山口大学, 医学系研究科, 助手 2006: 山口大学, 大学院・医学系研究科, 助手 2006: 山口大学, 大学院医学系研究科, 助手 2004 – 2005: 山口大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine / Basic Section 53020:Cardiology-related / Anesthesiology/Resuscitation studies / Basic Section 58080:Gerontological nursing and community health nursing-related / Basic Section 58070:Lifelong developmental nursing-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator リアノジン受容体 / 心不全 / 致死的不整脈 / カルモジュリン / 不整脈 / 興奮収縮連関 / 心肥大 / 筋小胞体 / ryanodine receptor / calmodulin … More / E-C coupling / 心筋細胞 / Herpud1 / NFAT / herpud1 / point mutation / lethal arrhythmia / heart failure / rvanodine recentor / calcium / sarcoplasmic reticulu / 内科 / 突然変異 / カルシウム / EC coupling / K201 / 心室性不整脈 / 分子心臓病態学 … More Except Principal Investigator リアノジン受容体 / 心不全 / ダントロレン / カルモジュリン / 不整脈 / 筋小胞体 / カルシウム / 心肥大 / heart failure / 致死的不整脈 / カルシウムハンドリング / 悪性高熱症 / protein phosphatase 1β / ryanodine receptor / 拡張不全 / EC coupling / 心室頻拍 / arrhythmia / dantrolene / 点突然変異 / アデノ随伴ウイルスベクター / RNAi / gene therapy / adeno-associated virus vector / 心室頻拍症 / 小胞体Ca制御 / スキャホールド / 光干渉断層法 / 不安定プラーク / 心筋梗塞 / インターネット / 周産期 / アプリ / モニタリング / セルフケア / メンタルヘルス / 小胞体ストレス / HFpEF / ERストレス / 認知症 / 教育プログラム / 看取り / 地域密着型 / エイジング・イン・プレイス / 肝硬変 / 肝臓修復細胞 / アデノシンデアミナーゼ / MAFLD / 電子顕微鏡 / 肝脂肪化 / 肝線維化 / iPS細胞 / 間葉系幹細胞 / 再生医療 / 致死的不整脈致死的不整脈 / シグナル伝達 / HDAC / 病的心肥大 / HDAC5 / アンレキサノクス / GRK5 / 弛緩障害 / 高血圧 / internal medicine / 内科 / point mutation / lethal arrhythmia / rvanodine receptor / scalcium / sarcoplasmic reticulum / Calcium / Ryanodine receptor / Sarcoplasmic reticulum / Heart failure / CPVT / ARVC / ドメイン連関障害 / 酸化ストレス / 分子心臓学 / カテコラミン誘発性心室頻拍 / カルシウム動態 / 肥大型心筋症 / 心筋特異的ノックアウトマウス / Cカルシウム循環 / 心筋細胞 / カルシウム循環 / protein phosphatase 1 beta isoform / BNP / protein phosphatase 1 beta / AAV9ベクター / RNAi干渉 / 遺伝子導入 / RNA干渉 / AAVベクター / B-type natriuretic peptide promoter / protein phosphatase / calcium / longitudinal SR / junctional SR / shotgun proteomics / sarcoplasmic reticulum(SR) / タイチン Less

Community-Based End-of-Life Support and Dementia Prevention Programs for Aging in Place
- Principal Investigator
  
  永田千鶴
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58080:Gerontological nursing and community health nursing-related
- Research Institution
  Yamaguchi University
Development of a new treatment method for HFpEF by correcting endoplasmic reticulum function
- Principal Investigator
  
  矢野雅文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
妊娠初期から始めるうつ病への移行を防ぐセルフモニタリングの実証研究
- Principal Investigator
  
  伊東美佐江
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58070:Lifelong developmental nursing-related
- Research Institution
  Yamaguchi University
心筋梗塞ハイリスク病変に対する血管小胞体Ca制御による新規プラーク安定化療法の開発
- Principal Investigator
  
  岡村誉之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
The cell identification research of bone marrow drived liver repaired cell in the new liver regeneration therapy
- Principal Investigator
  
  山本直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Yamaguchi University
A new treatment for heart failure and cardiac hypertrophy by controlling calmodulin translocation into the nucleusPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
DASH食を用いた包括的健康行動促進プログラムの開発
- Principal Investigator
  
  河村敦子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58080:Gerontological nursing and community health nursing-related
- Research Institution
  Yamaguchi University
Treatment of heart failure, cardiac hypertrophy, and fatal arrhythmia by ryanodine receptor-bound calmodulin regulation
- Principal Investigator
  
  YANO MASAFUMI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Targetting ryanodine receptors for anti-heart failure and anti-arrhythmic therapy
- Principal Investigator
  
  Kobayashi Shigeki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Novel treatment of arrhythmia and heart failure by controlling the domain of ryanodine receptorsPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Explore the new heart failure therapy focus on calmodulin translocation in cardiac myocytes
- Principal Investigator
  
  ODA Tetsuro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Novel therapy of arrhythmia targeting key domain in ryanodine receptorPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Ryanodine receptor-targeting therapy for heart failure and lethal arrhythmia
- Principal Investigator
  
  KOBAYASHI Shigeki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity
- Principal Investigator
  
  ODA Tetsuro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Development of novel arrhythmia therapy using K201 binding core in RyR2 moleclePrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor
- Principal Investigator
  
  KOBAYASHI SHIGEKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
Development of therapeutic therapy for regression of cardiac hypertrophy in hypertrophic cardiomyopathy
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Establishment of Molecular Therapy for Severe Heart Failure and Intractable Fetal Arrhythmia
- Principal Investigator
  
  MATSUZAKI Masunori
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Development of novel therapeutic strategy for heart failure which targets aberrant phosphorylation status in the sarcoplasmic reticulum of failing hearts
- Principal Investigator
  
  IKEDA Yasuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Novel therapeutic strategy of the fatal arrhythmia targeting specific domain in the ryanodine receptor moleclePrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor
- Principal Investigator
  
  KOBAYASHI Shigeki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
Exploration into the Development of New Therapy for Heart Failure by Modifying Sarcoplasmic Reticulum Nanodomain Function
- Principal Investigator
  
  MATSUZAKI Masunori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
拡張不全の新しいメカニズム:細胞内カルシウム過負荷とタイチンの重要性
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Establishment of molecular targeting therapy for duonic heart failure bystabilizmgryanodine receptor
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Ryanodine receptor as a novel therapeutic target of lethal arrhythmiaPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Elucidation of molecular mechanism and treatment for abnormal ryanodine receptor in patients with malignant hyperthermia and lethal arrhythmia
- Principal Investigator
  
  KOBAYASHI Shigeki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
Acquisition of resistance against heart failure by incorporation of ryanodine receptor stabilizing peptide to cardiomyocyte
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University

[Book] Heart Failure Pathophyiology in upportive Care in Heart Failure.2008
- Author(s)
  Ikeda Y, Yamamoto T, Yano M, Matsuzaki M.
- Publisher
  Oxford University Press. Ch.
- Data Source
  KAKENHI-PROJECT-20590868
[Book] Oxford University Press2008
- Author(s)
  Ikeda Y, Yamamoto T, Yano M, Matsuzaki M.
- Publisher
  Heart Failure Pathophyiology in Supportive Care for Cardiac Patient
- Data Source
  KAKENHI-PROJECT-19209030
[Journal Article] Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells2023
- Author(s)
  Fujioka Riko、Yamamoto Takeshi、Maruta Akihiro、Nakamura Yoshihide、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 652 Pages: 61-67
- DOI
  10.1016/j.bbrc.2023.02.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08128
[Journal Article] RyR2-stabilization therapy with dantrolene against left ventricular remodeling and lethal arrhythmia in heart failure2023
- Author(s)
  Kobayashi Shigeki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 182 Pages: 25-27
- DOI
  10.1016/j.yjmcc.2023.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-21K08054
[Journal Article] Effects of pemafibrate on left ventricular diastolic function in patients with type 2 diabetes mellitus: a pilot study2023
- Author(s)
  Yamamoto Kaoru、Ohta Yasuharu、Taguchi Akihiko、Akiyama Masaru、Nakabayashi Hiroko、Nagao Yuko、Ryoko Hatanaka、Wada Yasuaki、Yamamoto Takeshi、Yano Masafumi、Tanizawa Yukio
- Journal Title
  
  Diabetology International
  
  Volume: 14 Issue: 4 Pages: 434-439
- DOI
  10.1007/s13340-023-00645-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08626, KAKENHI-PROJECT-23K06401, KAKENHI-PROJECT-21K08054
[Journal Article] Preoperative neutrophil-to-lymphocyte ratio correlates with PD-L1 expression in immune cells of patients with malignant pleural mesothelioma and predicts prognosis2023
- Author(s)
  Okita Riki、Kawamoto Nobutaka、Okada Masanori、Inokawa Hidetoshi、Yamamoto Naoki、Murakami Tomoyuki、Ikeda Eiji
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 5260-5266
- DOI
  10.1038/s41598-023-31448-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08991, KAKENHI-PROJECT-19K09298, KAKENHI-PROJECT-22K08057, KAKENHI-PROJECT-18K08005
[Journal Article] RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure2023
- Author(s)
  Fujii Shohei、Kobayashi Shigeki、Chang Yaowei、Nawata Junya、Yoshitomi Ryosuke、Tanaka Shinji、Kohno Michiaki、Nakamura Yoshihide、Ishiguchi Hironori、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Okamura Takayuki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 178 Pages: 36-50
- DOI
  10.1016/j.yjmcc.2023.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686
[Journal Article] Metabolic Analysis of DFO-Resistant Huh7 Cells and Identification of Targets for Combination Therapy2023
- Author(s)
  Fujisawa K, Matsumoto T, Yamamoto N, Yamasaki T, Takami T.
- Journal Title
  
  Metabolites.
  
  Volume: 13(10) Issue: 10 Pages: 1068-1073
- DOI
  10.3390/metabo13101073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08057, KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-20K08289, KAKENHI-PROJECT-23K27587
[Journal Article] The impact of geriatric nutritional risk index on one-year outcomes in hospitalized elderly patients with heart failure2023
- Author(s)
  Miura Masakazu、Okuda Shinichi、Murata Kazuhiro、Ohno Yutaka、Katou Satoshi、Nakao Fumiaki、Ueyama Takeshi、Yamamoto Takeshi、Ikeda Yasuhiro
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 10 Pages: 1190548-1190548
- DOI
  10.3389/fcvm.2023.1190548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08054
[Journal Article] Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice2023
- Author(s)
  Yano Yasutake、Kobayashi Shigeki、Uchida Tomoyuki、Chang Yaowei、Nawata Junya、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 642 Pages: 175-184
- DOI
  10.1016/j.bbrc.2022.12.063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Journal Article] Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats2023
- Author(s)
  Nawata Junya、Yamamoto Takeshi、Tanaka Shinji、Yano Yasutake、Uchida Tomoyuki、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 34 Pages: 101449-101449
- DOI
  10.1016/j.bbrep.2023.101449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128
[Journal Article] Adenylate Kinase Isozyme 3 Regulates Mitochondrial Energy Metabolism and Knockout Alters HeLa Cell Metabolism2022
- Author(s)
  Fujisawa Koichi、Wakazaki Maina、Matsuzaki Aya、Matsumoto Toshihiko、Yamamoto Naoki、Noma Takafumi、Takami Taro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 8 Pages: 4316-4319
- DOI
  10.3390/ijms23084316
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08289, KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-22K08057, KAKENHI-PROJECT-20H03663, KAKENHI-PROJECT-20K08358
[Journal Article] Involvement of DNA Damage Response via the Ccndbp1-Atm-Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis2022
- Author(s)
  Horigome R, Kamimura K, Niwa Y, Ogawa K, Mizuno KI, Fujisawa K, Yamamoto N, Takami T, Sugano T, Sakamaki A, Kamimura H, Takamura M, Terai S.
- Journal Title
  
  J Clin Med.
  
  Volume: 11(13) Issue: 13 Pages: 3674-3680
- DOI
  10.3390/jcm11133674
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-20K08289, KAKENHI-PROJECT-20K08326, KAKENHI-PROJECT-22K08057, KAKENHI-PROJECT-20H03663
[Journal Article] Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice2022
- Author(s)
  Sakai Chihiro、Mikawa Mei、Yamamoto Takeshi、Uchida Tomoyuki、Nakamura Yoshihide、Akase Hideaki、Suetomi Takeshi、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 623 Pages: 51-58
- DOI
  10.1016/j.bbrc.2022.07.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20K17119
[Journal Article] Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.2022
- Author(s)
  Tanaka S, Yamamoto T, Mikawa M, Nawata J, Fujii S, Nakamura Y, Kato T, Fukuda M, Suetomi T, Uchinoumi H, Oda T, Okuda S, Okamura T, Kobayashi S, Yano M.
- Journal Title
  
  Heart Rhythm.
  
  Volume: S1547 Issue: 6 Pages: 00119-00119
- DOI
  10.1016/j.hrthm.2022.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20K17119
[Journal Article] Stabilizing Tetrameric Structure of Ryanodine Receptor Cures Lethal Arrhythmia in Heart Failure2022
- Author(s)
  Kobayashi Shigeki、Yamamoto Takeshi、Yoshiga Yasuhiro、Okamura Takayuki、Kawano Reo、Yano Masafumi
- Journal Title
  
  Circulation: Arrhythmia and Electrophysiology
  
  Volume: 15 Issue: 10 Pages: 714-717
- DOI
  10.1161/circep.122.011220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20H03677
[Journal Article] Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.2022
- Author(s)
  58)Nawata T, Sakai H, Honda T, Otsuka M, Fujita H, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 624 Pages: 141-145
- DOI
  10.1016/j.bbrc.2022.07.111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06803, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20H03677
[Journal Article] An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells2022
- Author(s)
  Fujisawa Koichi、Takami Taro、Matsumoto Toshihiko、Yamamoto Naoki、Yamasaki Takahiro、Sakaida Isao
- Journal Title
  
  Cancer Metabolism
  
  Volume: 10 Issue: 1 Pages: 8-16
- DOI
  10.1186/s40170-022-00284-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08289, KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-22K08057, KAKENHI-PROJECT-20H03663, KAKENHI-PROJECT-20K08358
[Journal Article] Evaluation of the Effects of Microgravity on Activated Primary Human Hepatic Stellate Cells2022
- Author(s)
  Fujisawa Koichi、Nishimura Yuto、Sakuragi Akino、Duponselle Jolien、Matsumoto Toshihiko、Yamamoto Naoki、Murata Tomoaki、Sakaida Isao、Takami Taro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 13 Pages: 7429-7429
- DOI
  10.3390/ijms23137429
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08289, KAKENHI-PROJECT-20H03663, KAKENHI-PROJECT-20K08358, KAKENHI-PROJECT-22K08057, KAKENHI-PROJECT-18K08005
[Journal Article] Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes.2022
- Author(s)
  Mikawa M, Sakai C, Yamamoto T, Nakamura Y, Tanaka S, Tominaga N, Inamitsu M, Oda T, Kobayashi S, Yano M.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 30 Pages: 101248-101248
- DOI
  10.1016/j.bbrep.2022.101248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128
[Journal Article] Effects of tumor-infiltrating CD8+ T cells, PD1/PD-L1 axis, and expression patterns of HLA class I on the prognosis of patients with malignant pleural mesothelioma who underwent extra-pleural pneumonectomy2022
- Author(s)
  Okita Riki、Mimura-Kimura Yuka、Kawamoto Nobutaka、Yamamoto Naoki、Umeda Masashi、Okada Masanori、Inokawa Hidetoshi、Mimura Yusuke、Murakami Tomoyuki、Nakata Masao、Okabe Kazunori
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 4 Pages: 865-879
- DOI
  10.1007/s00262-022-03292-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09298, KAKENHI-PROJECT-22K08057, KAKENHI-PROJECT-18K08005
[Journal Article] Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells2022
- Author(s)
  Uchida Tomoyuki、Oda Tetsuro、Yamamoto Takeshi、Inamitsu Masako、Sakai Chihiro、Uchinoumi Hitoshi、Suetomi Takeshi、Nakamura Yoshihide、Okamoto Yoko、Tateda Satomi、Fujii Shohei、Tanaka Shinji、Nawata Junya、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 628 Pages: 155-162
- DOI
  10.1016/j.bbrc.2022.08.069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Journal Article] Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease2021
- Author(s)
  Nakamura Yoshihide、Yamamoto Takeshi、Xu Xiaojuan、Kobayashi Shigeki、Tanaka Shinji、Tamitani Masaki、Saito Takashi、Saido Takaomi C.、Yano Masafumi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 7289-7289
- DOI
  10.1038/s41598-021-86822-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128
[Journal Article] Low-cost and High-Precision Stepping Motor Controlled Multi-Point Automatic Time-Lapse Microscope.2021
- Author(s)
  Maruta A, Sakai C, Mikawa M, Akita H, Inamitsu M, Fujioka R, Saiki Y, Yamamoto T
- Journal Title
  
  the Bulletin of the Yamaguchi Medical School
  
  Volume: 68 Pages: 41-47
- NAID
  120007178346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054
[Journal Article] Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice2020
- Author(s)
  Sufu-Shimizu Yoko、Okuda Shinichi、Kato Takayoshi、Nishimura Shigehiko、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 431-438
- DOI
  10.1016/j.bbrc.2020.01.107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K08039
[Journal Article] Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts2020
- Author(s)
  Kajii Toshiro、Kobayashi Shigeki、Shiba Sho、Fujii Shohei、Tamitani Masaki、Kohno Michiaki、Nakamura Yoshihide、Nanno Takuma、Kato Takayoshi、Okuda Shinichi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Issue: 1 Pages: 57-63
- DOI
  10.1016/j.bbrc.2019.10.071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178
[Journal Article] G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model2020
- Author(s)
  Hamada Yoriomi、Yamamoto Takeshi、Nakamura Yoshihide、Sufu-Shimizu Yoko、Nanno Takuma、Fukuda Masakazu、Ono Makoto、Oda Tesuro、Okuda Shinichi、Ueyama Takeshi、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 21 Pages: 100711-100711
- DOI
  10.1016/j.bbrep.2019.100711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K15890
[Journal Article] Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling2020
- Author(s)
  Kohno Michiaki、Kobayashi Shigeki、Yamamoto Takeshi、Yoshitomi Ryosuke、Kajii Toshiro、Fujii Shohei、Nakamura Yoshihide、Kato Takayoshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Watanabe Kenji、Mizukami Yoichi、Yano Masafumi
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 714-714
- DOI
  10.1038/s42003-020-01443-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11128, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-18K08572, KAKENHI-PROJECT-20H03677
[Journal Article] Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca 2+ level and ER stress2020
- Author(s)
  Tamitani M, Yamamoto T, Yamamoto N, Fujisawa K, Tanaka S, Nakamura Y, Uchinoumi H, Oda T, Okuda S, Takami T, Kobayashi S, Sakaida I, Yano M.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 23:100787. Pages: 100787-100793
- DOI
  10.1016/j.bbrep.2020.100787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20H03663
[Journal Article] Cytokine Adsorption to Polymyxin B-Immobilized Fiber: An in vitro Study2020
- Author(s)
  Utsunomiya Toshiaki、Mimura-Kimura Yuka、Yamamoto Takeshi、Aoe Keisuke、Oishi Keiji、Kamei Haruhito、Matsunaga Kazuto、Yano Masafumi、Mimura Yusuke
- Journal Title
  
  Blood Purification
  
  Volume: 50 Issue: 2 Pages: 1-8
- DOI
  10.1159/000510290
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-18K16152, KAKENHI-PROJECT-21K08180
[Journal Article] Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia2019
- Author(s)
  Nakamura Yoshihide、Yamamoto Takeshi、Kobayashi Shigeki、Tamitani Masaki、Hamada Yoriomi、Fukui Go、Xu Xiaojuan、Nishimura Shigehiko、Kato Takayoshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Yano Masafumi
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 11 Pages: 1-18
- DOI
  10.1172/jci.insight.126112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178
[Journal Article] CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca 2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy2018
- Author(s)
  Okuda Shinichi、Sufu-Shimizu Yoko、Kato Takayoshi、Fukuda Masakazu、Nishimura Shigehiko、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Morimoto Sachio、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 496 Issue: 4 Pages: 1250-1256
- DOI
  10.1016/j.bbrc.2018.01.181
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08540, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin2018
- Author(s)
  Oda Tetsuro、Yamamoto Takeshi、Kato Takayoshi、Uchinoumi Hitoshi、Fukui Go、Hamada Yoriomi、Nanno Takuma、Ishiguchi Hironori、Nakamura Yoshihide、Okamoto Yoko、Kono Michiaki、Okuda Shinichi、Kobayashi Shigeki、Bers Donald M.、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 125 Pages: 87-97
- DOI
  10.1016/j.yjmcc.2018.10.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K09502, KAKENHI-PROJECT-17H04178
[Journal Article] Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.2018
- Author(s)
  Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 印刷中 Issue: 6 Pages: 905-914
- DOI
  10.1016/j.hrthm.2018.02.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension2017
- Author(s)
  Tanabe N, Ikeda S, Tahara N, Fukuda K, Hatano M, Ito H, Nakayama T, Anzai T, Hashimoto A, Inoue T, Kajinami K, Kihara Y, Kinoshita H, Kuwahara K, Murohara T, Okazaki O, Sakai S, Satoh T, Takeda Y, Takeishi Y, Taniguchi M, Watanabe H, Yamamoto T, Yamauchi-Takihara K, Yoshioka K, Sasayama S.
- Journal Title
  
  Circ J
  
  Volume: 81 Issue: 9 Pages: 1360-1367
- DOI
  10.1253/circj.CJ-16-1348
- NAID
  130006003900
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-16H03255, KAKENHI-PROJECT-16H05220, KAKENHI-PROJECT-15K09084, KAKENHI-PROJECT-26461097, KAKENHI-PROJECT-17K09564
[Journal Article] Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.2017
- Author(s)
  Kato T, Yamamoto T, Nakamura Y, Nanno T, Fukui G, Sufu Y, Hamada Y, Maeda T, Nishimura S, Ishiguchi H, Murakami W, Fukuda M, Xu X, Hino A, Ono M, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 14 Issue: 1 Pages: 120-127
- DOI
  10.1016/j.hrthm.2016.10.019
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-16K15443, KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-26293189
[Journal Article] Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes.2016
- Author(s)
  Murakami W, Kobayashi S, Susa T, Nanno T, Ishiguchi H, Myoren T, Nishimura S, Kato T, Hino A, Oda T, Okuda S, Yamamoto T, Yano M.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 9 Pages: e0163250-e0163250
- DOI
  10.1371/journal.pone.0163250
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K15443, KAKENHI-PROJECT-26293189
[Journal Article] Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity2015
- Author(s)
  Tetsuro Oda, Yi Yang, Hitoshi Uchinoumi, David D. Thomas, Ye Chen-Izu, Takayoshi Kato, Takeshi Yamamoto, Masafumi Yano, Razvan L. Cornea, Donald M. Bers
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 85 Pages: 240-248
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670403
[Journal Article] A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.2015
- Author(s)
  Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 1 Pages: e0114314-e0114314
- DOI
  10.1371/journal.pone.0114314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-26670404
[Journal Article] Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.2015
- Author(s)
  Oda T, Yang Y, Uchinoumi H, Thomas DD, Chen-Izu Y, Kato T, Yamamoto T, Yano M, Cornea RL, Bers DM.
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 85 Pages: 240-248
- DOI
  10.1016/j.yjmcc.2015.06.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-26293189
[Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes2014
- Author(s)
  Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 448(1) Issue: 1 Pages: 1-7
- DOI
  10.1016/j.bbrc.2014.03.152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23591082, KAKENHI-PROJECT-23592256, KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-26670404
[Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes2014
- Author(s)
  Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts2012
- Author(s)
  Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
- Journal Title
  
  Cardiovasc Res
  
  Volume: 96(3) Issue: 3 Pages: 433-43
- DOI
  10.1093/cvr/cvs271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23591082, KAKENHI-PROJECT-23592256
[Journal Article] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts2012
- Author(s)
  Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
- Journal Title
  
  Cardiovasc Res
  
  Volume: 96 Pages: 433-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Isoform-Specific Roles of Protein Phosphatase 1 Catalytic Subunits in Sarcoplasmic Reticulum-Mediated Ca2+ Cycling2011
- Author(s)
  Aoyama H, Ikeda Y, Miyazaki Y, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M
- Journal Title
  
  Cardiovasc Res
  
  Volume: 89(1) Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390241
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca channel release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124(6) Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390241
[Journal Article] Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling.2011
- Author(s)
  Aoyama H, Ikeda Y, Miyazaki Y, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 89(1)
  
  Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca2+ release leading to catecholaminergic polymorphic ventricular tachycardia.2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circulation
  
  Volume: 124 Pages: 682-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591082
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca^<2+> release leading to catecholaminergic polymorphic2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  ventricular tachycardia. Circulation
  
  Volume: 124(6) Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659154
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124(6) Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591082
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca channel release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124(6) Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590932
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124 Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca^<2+> release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Takeshi Suetomi
- Journal Title
  
  Circulation
  
  Volume: 124 Issue: 6 Pages: 682-694
- DOI
  10.1161/circulationaha.111.023259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390241, KAKENHI-PROJECT-21590932, KAKENHI-PROJECT-22659154, KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23592256
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2 (R2474S/+) knock-in mouse model.2010
- Author(s)
  Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
- Journal Title
  
  Cir J. 74
  
  Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Matsuzaki M. Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic2010
- Author(s)
  Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T
- Journal Title
  
  Polymorphic Ventricular Tachycardia in a RyR2(R2474S/+) Knock-In Mouse Model. Circ J
  
  Volume: 74 Pages: 2579-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659154
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, lkeda Y, lkemoto N, Matsuzaki M.
- Journal Title
  
  Biochem Biophys Res Commun. 394(3)
  
  Pages: 660-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394 Pages: 660-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659154
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M
- Journal Title
  
  Biochem Biophys Res Commun. 2010 Apr 9
  
  Volume: 394(3) Pages: 660-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590932
[Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure.2010
- Author(s)
  Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 87
  
  Pages: 609-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394(3) Pages: 660-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390241
[Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circ Res
  
  Volume: 106(8) Pages: 1413-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390241
[Journal Article] Norepinephrine spillover during exercise as a novel parameter to evaluate the severity of heart failure.2010
- Author(s)
  Ando M, Yamamoto T, Hino A, Sato T, Nakamura Y, Matsuzaki M.
- Journal Title
  
  J Nucl Cardiol. 17(5)
  
  Pages: 868-873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Ryanodine Receptor. Cir Res
  
  Volume: 106 Pages: 1413-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659154
[Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, lkeda Y, Ohkusa T, lkemoto N, Matsuzaki M.
- Journal Title
  
  Circ Res. 106(8)
  
  Pages: 1413-1424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Biochem Biophys Res Commun. 394
  
  Pages: 660-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ releasein heart failure2010
- Author(s)
  Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
- Journal Title
  
  Cardiovasc Res
  
  Volume: 87 Pages: 609-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659154
[Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cir Res. 81
  
  Pages: 1413-1423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circ Res. 2010 Apr 30
  
  Volume: 106(8) Pages: 1413-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590932
[Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure.2010
- Author(s)
  Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 87(4)
  
  Pages: 609-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Isoform-Specific Roles of Protein Phosphatase 1 Catalytic Subunits in Sarcoplasmic Reticulum-Mediated Ca2+ Cycling2010
- Author(s)
  Aoyama H, Ikeda Y, Miyazaki Y, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M
- Journal Title
  
  Cardiovasc Res. 2011 Jan 1
  
  Volume: 89(1) Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590932
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2 R2474S/+knock-in mouse model.2010
- Author(s)
  Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
- Journal Title
  
  Circ J. 74(12)
  
  Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Role of ryanodine receptor as a Ca(2+) regulatory center in normal and failing hearts.2009
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Matsuzaki M.
- Journal Title
  
  J Cardiol. 53
  
  Pages: 1-7
- NAID
  10025182309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia2009
- Author(s)
  Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol 53(21)
  
  Pages: 1993-2005
- Data Source
  KAKENHI-PROJECT-19209030
[Journal Article] Role of ryanodine receptor as a Ca2+ regulatory center in normal and failing hearts.2009
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Matsuzaki M.
- Journal Title
  
  J Cardiol. 53(1)
  
  Pages: 1-7
- NAID
  10025182309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.2009
- Author(s)
  Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 81(3)
  
  Pages: 536-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.2009
- Author(s)
  Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, lkemoto N, Matsuzaki M.
- Journal Title
  
  J Am Coll Cardiol. 53(21)
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Role of ryanodine receptor as a Ca(2+) regulatory center in normal and failing hearts2009
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Matsuzaki M.
- Journal Title
  
  J Cardiol 53(1)
  
  Pages: 1-7
- NAID
  10025182309
- Data Source
  KAKENHI-PROJECT-19209030
[Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.2009
- Author(s)
  Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 81
  
  Pages: 536-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor.2009
- Author(s)
  Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, IkemotoN, Matsuzaki M.
- Journal Title
  
  J Am Coll Cardiol. 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca^<2+> leak in failing hearts2008
- Author(s)
  Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res
- Data Source
  KAKENHI-PROJECT-19209030
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Takeshi Yamamoto
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390234
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Yamamoto, T, Yano, M, Xu, X, Uchinoumi, H, Tateishi, H, Mochizuki, M, Oda, T, Kobayashi, S, Ikemoto, N, Matsuzaki, M
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.2008
- Author(s)
  Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circulation. 117(6)
  
  Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  山本健
- Journal Title
  
  Circulation 117
  
  Pages: 782-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590777
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.2008
- Author(s)
  Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circulation. 117
  
  Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  山本健
- Journal Title
  
  Circulation 117
  
  Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591706
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Takeshi Yamamoto
- Journal Title
  
  Circulation 117
  
  Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Takeshi Yamamoto
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659228
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correctchannel disorder in failing hearts.2008
- Author(s)
  Yamamoto T
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209030
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Yamamoto, T, et. al.
- Journal Title
  
  Circulation 117(6)
  
  Pages: 762-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590777
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Yamamoto, T, Yano, M, Xu, X, Uchinoumi, H, Tateishi, H, Mochizuki, M, Oda, T, Kobayashi, S, Ikemoto, N, Matsuzaki, M
- Journal Title
  
  Circulation 117(6)
  
  Pages: 762-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390234
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Takeshi Yamamoto
- Journal Title
  
  Circulation 117
  
  Pages: 762-772
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591706
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.2008
- Author(s)
  Yamamoto T
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Identification of target domains of the cardiac ryanodine receptor tocorrect channel disorder in failing hearts2008
- Author(s)
  Takeshi Yamamoto
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390234
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.2008
- Author(s)
  Yamamoto T
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209030
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circulation 117(6)(PubMed PMID : 18227387)
  
  Pages: 762-72
- Data Source
  KAKENHI-PROJECT-19209030
[Journal Article] Defective Ca2+ cycling as a key pathogenic mechanism of heart failure.2008
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M.
- Journal Title
  
  Circ J. 72
  
  Pages: 22-30
- NAID
  110006935628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Defective Ca2+ cycling as a key pathogenic mechanism of heart failure.2008
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M.
- Journal Title
  
  Circ J. 72
- NAID
  110006935628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts. Circulation2008
- Author(s)
  Yamamoto T, et. al.
- Journal Title
  
  Circulation 117
  
  Pages: 762-772
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590777
[Journal Article] 「研究成果報告書概要(欧文)」より2007
- Author(s)
  Mochizuki, M, Yano, M, Oda, T, Tateishi, H, Kobayashi, S, Yamamoto, T, Ikeda, Y, Ohkusa, T, Ikemoto, N, Matsuzaki, M
- Journal Title
  
  JAm Coll Cardiol 49(16)
  
  Pages: 1722-32
- Data Source
  KAKENHI-PROJECT-18390234
[Journal Article] Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca^<2+>leak via stabilization of ryanodine receptor in heart failure2007
- Author(s)
  Mamoru, Mochizuki, Masafumi, Yano, Tetsuro, Oda, Hiroki, Tateishi, Shigeki Kobayashi, Takeshi, Yamamoto, Yasuhiro, Ikeda, Tomoko, Ohkusa, Noriaki, Ikemoto, Masunori, Matsuzaki
- Journal Title
  
  J Am Coll Cardiol 49
  
  Pages: 1722-1732
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Journal Article] Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure2007
- Author(s)
  Mochizuki M, Yano M, Oda T, Tateishi H, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  J Am Coll Cardiol 49(16)
  
  Pages: 1722-32
- Data Source
  KAKENHI-PROJECT-19209030
[Patent] 線維化を伴う肝疾患を予防又は治療するための医薬組成物2023
- Inventor(s)
  山本直樹, 高見太郎, 松本俊彦, 川本大樹
- Industrial Property Rights Holder
  国立大学法人山口大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] 自己完結型肝硬変再生療法の開発と細胞外小胞を介した作用機序の解明2023
- Author(s)
  松本俊彦, 川本大樹, 石川剛, 山本直樹, 高見太郎
- Organizer
  第30回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] 肝臓再生療法における自己骨髄間葉系幹細胞由来細胞外小胞の作用機序の解析2023
- Author(s)
  川本大樹, 松本俊彦, 山本直樹, 高見太郎
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] 肝臓再生療法における自己骨髄間葉系幹細胞由来細胞外小胞の作用機序の解析2023
- Author(s)
  川本大樹, 松本俊彦, 山本直樹, 高見太郎
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] The iPS-derived mesenchymal stem cells ameliorated liver fibrosis and liver fatty deposition in NAFLD/MAFLD-related cirrhotic mice2023
- Author(s)
  Naoki Yamamoto, Ami Enomoto,Shizuka Aritomi,Tsuyoshi Fujioka,Daiki Kawamoto, Kaori Hamamoto, Shuhei Shinoda,Toshihiko Matsumoto,Koichi Fujisawa,Taro Takami
- Organizer
  The Liver meeting AASLD in Boston 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] リアノジン受容体安定化治療が心筋梗塞後の左室リモデリングや心室頻拍を抑制する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、縄田純也、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第9回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-21K08054
[Presentation] 心筋型リアノジン受容体 4 量体構造の安定化は心筋梗塞後の予後を改善する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第122回日本循環器学会中国四国合同地方会
- Data Source
  KAKENHI-PROJECT-21K08054
[Presentation] 肝硬変症に対する新規治療方法の開発を目指して2023
- Author(s)
  山本直樹
- Organizer
  第129回山口大学医学会学術講演会総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] 肝線維化研究Revisited-肝臓学のBiologyからTranslationalへ肝星細胞とマクロファージの細胞間相互作用におけるmiR-142-3pの役割2022
- Author(s)
  松本俊彦, 山本直樹, 高見太郎
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] 培養自己骨髄間葉系幹細胞投与療法に対するexosomeを用いた補助療法の開発2022
- Author(s)
  原和冴, 松本俊彦, 藤澤浩一, 山本直樹, 高見太郎
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] 医師主導治験「自己完結型肝硬変再生療法」の開発とNASH肝硬変への有効性評価2022
- Author(s)
  高見太郎, 松本俊彦, 大田久美江, 児玉雅季, 藤村瑠意, 小島奈緒美, 山本直樹, 坂井田功
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K08057
[Presentation] Stabilization of RyR2 maintains right ventricular function, and improves prognosis in pulmonary hypertension2021
- Author(s)
  Shinji Tanaka，Takeshi Yamamoto，Jyunya Nawata，Shohei Fujii，Yoshihide Nakamura，Hitoshi Uchinoumi，Tetsuro Oda，Shigeki Kobayashi，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Improving Ca2+ handling prevent doxorubicin induced cardiomyopathy in mice2021
- Author(s)
  Yoshihide Nakamura，Takeshi Yamamoto， Shinji Tanaka，Hitoshi Uchinoumi，Tetsuro Oda，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Stabilization of RyR2 maintains right ventricular function, and improves prognosis in pulmonary hypertension2021
- Author(s)
  Shinji Tanaka, Takeshi Yamamoto, Junya Nawata, Shohei Fujii, Yoshihide Nakamura, Michiaki Kohno, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08054
[Presentation] The role of Herpud1 as a anti-hypertrophic gene in cardiomyocytes2021
- Author(s)
  Mei Mikawa, Takeshi Yamamoto, Chizuru Sakai, Riko Fujioka, Akihiro Maruta, Yoshihide Nakamura, Masako Inamitsu, Naoomi Tominaga, Masahumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08054
[Presentation] Dantrolene prevents right ventricular remodeling and ventricular tachycardia in pulmonary artery hypertension2021
- Author(s)
  Shinji Tanaka, Takeshi Yamamoto, Junya Nawata, Shohei Fujii, Yoshihide Nakamura, Michiaki Kohno, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第37回国際心臓研究学会日本部会
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] RyR2-targeting therapy improves left ventricular remodeling after myocardial infarction2021
- Author(s)
  Shohei Fujii，Shigeki Kobayashi，Yaowei Chang，Jyunya Nawata，Shinji Tanaka，Yoshihide Nakamura，Takeshi Suetomi，Hitoshi Uchinoumi，Tetsuro Oda，Takeshi Yamamoto，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Sterile Inflammation through Ca2+ Calmodulin-Dependent Protein Kinase II is Essential for Adverse Cardiac Remodeling2021
- Author(s)
  末冨建、奥田真一、岡本陽子、楯田聡美、河野通暁、梶井俊郎、内海仁志、小田哲郎、小林茂樹、山本　健、矢野雅文
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Enhancing calmodulin binding affinity to ryanodine receptor type2 can be a therapeutic target for heart failure with preserved ejection fraction2021
- Author(s)
  Tomoyuki Uchida，Tetsuro Oda，Takeshi Suetomi，Takeshi Yamamoto，Shigeki Kobayashi，Yoshihide Nakamura，Shohei Fujii，Hitoshi Uchinoumi，Shinji Tanaka，Jyunya Nawata，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Sterile inflammation through Ca2+/ Calmodulin-dependent protein kinase II (CaMKII) signaling is essential for adverse cardiac remodeling2021
- Author(s)
  Takeshi Suetomi，Shinichi Okuda，Satomi Tateda，Yoko Okamoto，Hitoshi Uchinoumi，Tetsuro Oda，Shigeki Kobayashi，Takeshi Yamamoto，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Anti-inflammatory approach for heart failure targeting Calcium-Calmodulin dependent protein kinase2020
- Author(s)
  Takeshi Suetomi, Michiaki Kono, Toshiro Kajii, Masaki Tamitani, Yoshihide Nakamura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Critical Role of Ryanodine Receptor Bound Calmodulin to Prevent Catecholaminergic Polymorphic Ventricular Tachycardia2019
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Masaki Tamitani, Yoriomi Hamada, Go Fukui, Xiaojuan Xu, Shigehiko Nishimura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masafumi Yano
- Organizer
  AHA BCVS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108
[Presentation] The Difference of Calmodulin-Ryanodine Receptor Affinity Between N-terminal, Central and C-terminal RyR2-CPVT Knock-in Mice2019
- Author(s)
  Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Mena Said, Rogerio Faustino, Razvan L Cornea, Univ of Minnesota, Xander H.t. Wehrens, Takeshi Yamamoto, Masafumi Yano, Donald M Bers
- Organizer
  AHA Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Critical Role of Ryanodine Receptor Bound Calmodulin to Prevent Catecholaminergic Polymorphic Ventricular Tachycardia2019
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Masaki Tamitani, Yoriomi Hamada, Go Fukui, Xiaojuan Xu, Shigehiko Nishimura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masafumi Yano
- Organizer
  AHA BCVS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] リアノジン受容体を分子標的とした心不全・不整脈治療2019
- Author(s)
  小林茂樹、山本健、矢野雅文
- Organizer
  第４０回日本循環制御医学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] The Difference of Calmodulin-Ryanodine Receptor Affinity Between N-terminal, Central and C-terminal RyR2-CPVT Knock-in Mice2019
- Author(s)
  Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Mena Said, Rogerio Faustino, Razvan L Cornea, Univ of Minnesota, Xander H.t. Wehrens, Takeshi Yamamoto, Masafumi Yano, Donald M Bers
- Organizer
  AHA Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108
[Presentation] Arrhythmia Treatment Targeting Ryanodine receptor2019
- Author(s)
  Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  The 66th Annual Meeting of the Japanese Heart Rhythm Sociaty
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108
[Presentation] Stabilization of CaMKII-phosphorylated RyR2Prevents the Development of Age-related Car-diomyopathy Caused by Transgenic CaMKII δ cOverexpression2018
- Author(s)
  Yoko Sufu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Stabilization of CaMKII-phosphorylated RyR2Prevents the Development of Age-related Car-diomyopathy Caused by Transgenic CaMKIIδc Overexpression2018
- Author(s)
  Yoko Sufu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Dantrolene Prevents Right Ventricular Hypertro-phy without Reducing Pulmonary Arterial Pres-sure in Monocrotaline-Induced PAH in Mice2018
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Go Fukui, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertro-phy without Reducing Pulmonary Arterial Pres-sure in Monocrotaline-Induced PAH in Mice2018
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Go Fukui, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Prevents Right Ventricular Hypertro-phy without Reducing Pulmonary Arterial Pres-sure in Monocrotaline-Induced PAH in Mice2018
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Go Fukui, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Ryanodine Receptor Targeting Therapy InhibitsCardiomyocyte Hypertrophy and RelaxationImpairment in the Compensated Pressure-Overloaded Heart2018
- Author(s)
  Michiaki Kono, Shigeki Kobayashi, Toshiro Kajii, Takuma Nanno, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Stabilization of CaMKII-phosphorylated RyR2Prevents the Development of Age-related Car-diomyopathy Caused by Transgenic CaMKIIδc Overexpression2018
- Author(s)
  Yoko Sufu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Ryanodine Receptor Targeting Therapy InhibitsCardiomyocyte Hypertrophy and RelaxationImpairment in the Compensated Pressure- Overloaded Heart2018
- Author(s)
  Michiaki Kono, Shigeki Kobayashi, Toshiro Kajii, Takuma Nanno, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Ryanodine Receptor Targeting Therapy InhibitsCardiomyocyte Hypertrophy and RelaxationImpairment in the Compensated Pressure-Overloaded Heart2018
- Author(s)
  Michiaki Kono, Shigeki Kobayashi, Toshiro Kajii, Takuma Nanno, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule2017
- Author(s)
  Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule2017
- Author(s)
  Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression2017
- Author(s)
  Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse2017
- Author(s)
  Hitoshi Uchinoumi, Ivanita Stefanon, Yi Yang, Mena Said, Xiaoqiong Dong, Rogerio Faustino, Jose L Puglisi, Ye Chen-Izu, Razvan L Cornea, Xander H Wehrens, Wayne S Chen, Takeshi Yamamoto, Yano Masafumi and Donald M Bers
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression2017
- Author(s)
  Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule2017
- Author(s)
  Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression2017
- Author(s)
  Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse2017
- Author(s)
  Hitoshi Uchinoumi, Ivanita Stefanon, Yi Yang, Mena Said, Xiaoqiong Dong, Rogerio Faustino, Jose L Puglisi, Ye Chen-Izu, Razvan L Cornea, Xander H Wehrens, Wayne S Chen, Takeshi Yamamoto, Yano Masafumi and Donald M Bers
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse2017
- Author(s)
  Hitoshi Uchinoumi, Ivanita Stefanon, Yi Yang, Mena Said, Xiaoqiong Dong, Rogerio Faustino, Jose L Puglisi, Ye Chen-Izu, Razvan L Cornea, Xander H Wehrens, Wayne S Chen, Takeshi Yamamoto, Yano Masafumi and Donald M Bers
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Ryanodine Receptor Bound Calmodulin as a Novel Therapeutic Target of Heart Failure and Cardiac Hypertrophy2016
- Author(s)
  山本健
- Organizer
  日本循環器学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Correction of the Defective Channel Gating of Cardiac Ryanodine Receptor Improves Cardiac Function and Suppresses Ventricular Arrhythmia in Post Myocardial Infarction Heart Failure2016
- Author(s)
  Hironori Ishiguchi, Shigeki Kobayashi, Michiaki Kohno, Takuma Nanno, Gou Fukui, Yoko Sufu-Shimizu, Yoriomi Hamada, Takako Maeda, Shigehiko Nishimura, Tetsuro Oda, Shinnichi Okuda, Takeshi Ueyama, Takeshi Yamamoto, Masafumi Yano
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Correction Of Impaired Calmodulin Binding To Ryr2 As A Novel Therapy Of Lethal Arrhythmia In The Pressure-overloaded Heart Failure2016
- Author(s)
  Yoshihide Nakamura,Takeshi Yamamoto, Yamaguchi Univ Graduate Sch of Med, Une, Japan; Takayoshi Kato, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Shigehiko Nishimura, Hironori Ishiguchi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Correction of Impaired Calmodulin Binding to Ryr2 as a Novel Therapy of Lethal Arrhythmia in the Pressure-Overloaded Heart Failure2016
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Takayoshi Kato, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Shigehiko Nishimura, Hironori Ishiguchi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Nuclear Translocation of Calmodulin, Which Dissociated From Cardiac Ryanodine Receptor, Promotes the Pathological Cardiac Hypertrophy2016
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Takayoshi Kato, Shigehiko Nishimura, Go Fukui, Shinichi Okuda, Shigeki Kobayashi, Donald Bers and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Correction of the Defective Channel Gating of Cardiac Ryanodine Receptor Improves Cardiac Function and Suppresses Ventricular Arrhythmia in Post Myocardial Infarction Heart Failure2016
- Author(s)
  Hironori Ishiguchi, Shigeki Kobayashi, Michiaki Kohno, Takuma Nanno, Gou Fukui, Yoko Sufu-Shimizu, Yoriomi Hamada, Takako Maeda, Shigehiko Nishimura, Tetsuro Oda, Shinnichi Okuda, Takeshi Ueyama, Takeshi Yamamoto and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Improvement of Defective Channel Function on RyR2 Mediated by CaMKII Activation Suppresses Arrhythmogenesis in TnT-related Hypertrophic Cardiomyopathy2016
- Author(s)
  Okuda, Yoko Sufu-Shimizu, Takayoshi Kato, Yoko Okamoto, Shigehiko Nishimura, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15443
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT With Mutation at CaM-like Domain2015
- Author(s)
  Shigehiko Nishimura，Takeshi Yamamoto，Go Fukui，Takako Maeda，Akihiro Hino，Takeshi Suetomi，Makoto Ono，Mamoru Mochizuki，Tetsuro Oda，Shinichi Okuda，Shigeki Kobayashi，Masafumi Yano
- Organizer
  88th Scientific Session of American Heart Association
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure2015
- Author(s)
  Go Fukui，Takeshi Yamamoto，Tkayoshi Kato，Takako Maeda，Shigehiko Nishimura，Akihiro Hino，Takeshi Suetomi，Makoto Ono，Mamoru Mochizuki，Tetsuro Oda，Shinichi Okuda，Shigeki Kobayashi，Masafumi Yano
- Organizer
  88th Scientific Session of American Heart Association
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation Is Located at CaM-like Domain of RyR22015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT with Mutation at CaM-like Domain2015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure.2015
- Author(s)
  Go Fukui, Takeshi Yamamoto, Takayoshi Kato, Takako Maeda, Shigehiko Nishimura, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation2014
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation2014
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure2014
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure2014
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dissociation of Calmodulin from RyR2 Plays a Key Role in Diastolic Ca2+ Leak from Sarcoplasmic Reticulum in Pressure-overload Heart Failure2014
- Author(s)
  Takeshi Yamamoto
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure2014
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Mapping the Binding Site of RyR2"Unzipping"Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy2014
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Mapping the Binding Site of RyR2 “Unzipping” Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Symposium Dissociation of Calmodulin from RyR2 Plays a Key Role in Diastolic Ca2+ Leak from Sarcoplasmic Reticulum in Pressure-overload Heart Failure2014
- Author(s)
  Takeshi Yamamoto
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation2014
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Cardiomyocyte Function by Inhibiting Ca2+ Leak through the Ryanodine Receptor in Failing Cardiomyocytes2014
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy2014
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Mapping the Binding Site of RyR2 “Unzipping” Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca^<2+> Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, (U.S.A)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas USA(Poster)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas,Tx, USA
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dissociation of Calmodulin from RyR2 Plays a Key Role in Diastolic Ca2+ Leak from Sarcoplasmic Reticulum in Pressure-overload Heart Failure2013
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第17回日本心不全学会学術集会
- Place of Presentation
  埼玉（大宮ソニックシティ）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] カテコラミン誘発性多形性心室頻拍関連遺伝子変異を有する異常なリアノジン受容体において、カルモジュリン結合能改善は催不整脈性を抑制する2013
- Author(s)
  福田昌和，山本　健，加藤孝佳，村上和華子，立石裕樹，土居正浩，奥田真一，小林茂樹，矢野雅文
- Organizer
  第102回日本循環器学会中国・四国合同地方会
- Place of Presentation
  高松（サンポートホール高松）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene inhibits aberrant Ca2+ release by stabilizing inter-domain interactions within the ryanodine receptor in cardiac troponin T-related familial hypertrophic cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Akihiro Hino, Takayoshi Katoh, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki, Masafumi Yano
- Organizer
  European Society of Cardiololgy Congress 2013
- Place of Presentation
  Amsterdam, Nederland
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas USA(Oral)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] カテコラミン誘発性多形性心室頻拍関連の遺伝子変異を持つリアノジン受容体におけるカルモジュリンの効果について2013
- Author(s)
  福田昌和，山本　健，西村滋彦，明連武樹，加藤孝佳，村上和華子，大野　誠，小田哲郎，奥田真一，土居正浩，小林茂樹，矢野雅文
- Organizer
  第61回日本心臓病学会学術集会
- Place of Presentation
  熊本（ホテル日航熊本）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas,Tx, USA
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas,Tx, USA
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Fixing Ca^<2+> Leakage From Cardiac Ryanodine Receptor by Low-dose ofβBlocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
- Organizer
  5th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles, (U.S.A) (Oral)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose of β Blocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Enhanced Binding of Calmodulin to RyR2 Inhibits Aberrant Ca2+ Release and Arrhythmogenesis in CPVT-Associated Mutation2012
- Author(s)
  Fukuda　M, Yamamoto　T, Kato T, Hino A, Suetomi T, Tateishi H, Doi M, Okuda S, Kobayashi S, Matsuzaki M, Yano M
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles(USA)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose ofβBlocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles USA(Oral)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Acceleration of the Early Diastolic Filing by Cardiac Re-synchronization is Important for Improving Symptoms of Severe Heart Failure2012
- Author(s)
  Takeshi Yamamoto
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2011
- Author(s)
  Takeshi Suetomi; Masafumi Yano; Takayoshi Kato; Masakazu Fukuda; Akihiro Hino; Masahiro Doi; Shinichi Okuda; Shigeki Kobayashi; Yasuhiro Ikeda; Takeshi Yamamoto; Masunori Matsuzaki
- Organizer
  84rd Scientific Session of American Heart Association
- Place of Presentation
  Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation2011
- Author(s)
  Masakazu Fukuda, Masafumi Yano, Takayoshi Kato, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  84rd Scientific Session of American Heart Association
- Place of Presentation
  Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia2011
- Author(s)
  Shigeki Kobayashi, Masafumi Yano, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  The 28th Annual Meeting of the International Society for Heart Research Japanese Section(招待講演)
- Place of Presentation
  The National Center of Science Building, Tokyo
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia(CPVT)2011
- Author(s)
  Suetomi T, Yano T, Kato T, Fukuda M, Hino A, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2011
- Place of Presentation
  Orland, USA
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation2011
- Author(s)
  Masakazu Fukuda, Masafumi Yano, Takayoshi Kato, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Florida (USA)
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia2011
- Author(s)
  Shigeki Kobayashi, Masafumi Yano,Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  The 28th Annual Meeting of the International Society for Heart Research Japanese Section
- Place of Presentation
  The National Center of Science Building(Tokyo) (Symposium)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2011
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Florida (USA)
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Matsuzaki M. Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation2011
- Author(s)
  Fukuda M, Yano M, Kato T, Hino A, Suetomi T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T
- Organizer
  American Heart association Scientific meeting
- Place of Presentation
  Orland, USA
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Correction of Defective Calmodulin Binding to Cardiac Ryanodine Receptor Inhibits Aberrant Ca2+ Release in CPVT-associated Mutation.2010
- Author(s)
  Masakazu Fukuda, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Makoto Ono, Hitoshi Uchinoumi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Correction of the defective inter-domain interaction within ryanodine receptor prevents the development of heart failure.2010
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Makoto Ohno, Shinichi Okuda, MasahiroDoi, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Mutation-linked defective domain interaction within the ryanodine receptor causes ca2+ leak leading to catecholaminergic polymorphic ventricular tachycardia2010
- Author(s)
  Suetomi T, Yano M, Fukuda M, Hino A, Ono M, Xu X, Susa T, Uchinoumi H, Oda T, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Matsuzaki M
- Organizer
  83rd Scientific Session of American Heart Association
- Place of Presentation
  Chicago, U. S. A.
- Data Source
  KAKENHI-PROJECT-21590932
[Presentation] Correction of Defective Conformational Regulation of the Cardiac Ryanodine Receptor is a New Therapeutic Strategy against Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2010
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki.
- Organizer
  The 74th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Increased Affinity of Calmodulin Binding to Cardiac Ryanodine Receptor Corrects the Defective Channel Gating in Failing Hearts.2010
- Author(s)
  Akihiro Hino, Masafumi Yano, Masakazu Fukuda, Takeshi Suetomi, Makoto Ono, Xiaojuan Xu, Hitoshi Uchinoumi, Takehisa Susa, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Increased Affinity of Calmodulin Binding to Cardiac Ryanodine Receptor Corrects the Defective Channel Gating in Failing Hearts2010
- Author(s)
  Hino A, Yano M, Fukuda M, Suetomi T, Ono M, Xu X, Uchinoumi H, Susa T, Doi M, Okuda S, Kobayashi S, Yamamoto T, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2010
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Isoform-specific role of protein phosphatase catalyticsubunits in sarcoplasmic reticulum mediated ca2+ cycling in cardiomyocytes2010
- Author(s)
  Ikeda Y, Aoyama H, Miyazaki Y, Yoshimura K, Yamamoto T, Yano M, Matsuzaki M
- Organizer
  20th World Congress of the International Society for Heart Research
- Place of Presentation
  Kyoto, Kyoto Internatioal Conference Center
- Data Source
  KAKENHI-PROJECT-21590932
[Presentation] Interruption of Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2010
- Author(s)
  Takeshi Yamamoto, Masafumi Yano, Masahiro Fukuda, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinich Okuda, Shigeki Kobayashi, Masunori Matsuzaki
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Chicago IL, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Isoform-specific role of prote in phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated ca2+ cycling2010
- Author(s)
  Ikeda Y, Aoyama H, Miyazaki Y, Shiraishi K, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M
- Organizer
  19th International Conference of the Cardiovascular System Dynamics Society
- Place of Presentation
  Fukuoka, Centennial Hall Kyushu University School of Medicine
- Data Source
  KAKENHI-PROJECT-21590932
[Presentation] Correction of Defective Calmodulin Binding to Cardiac Ryanodine Receptor Inhibits Aberrant Ca2+ Release in CPVT-associated Mutation2010
- Author(s)
  Fukuda M, Yano M, Hino A, Suetomi T, Xu X, Ono M, Uchinoumi H, Doi M, Okuda S, Kobayashi S, Yamamoto T, Matsuzaki M
- Organizer
  Inhibits Aberrant Ca^<2+> Release in CPVT-associated Mutation American Heart association Scientific meeting 2010
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Mutation-linked Defective Domain Interaction within the Ryanodine Receptor Causes Ca^<2+> Leak Leading to Catecholaminergic Polymorphic Ventricular Tachycardia2010
- Author(s)
  Suetomi T, Yano M, Fukuda M, Hino A, Ono M, Xu X, Susa T, Uchinoumi H, Oda T, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2010
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Interruption of Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2010
- Author(s)
  Takeshi Yamamoto
- Organizer
  American Heart Association, Scientific sessions 2010
- Place of Presentation
  Chicago
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Interruption of Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2010
- Author(s)
  Takeshi Yamamoto
- Organizer
  American Heart Association Scientific Sessions 2010
- Place of Presentation
  Chicago IL
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Mutation-linked Defective Domain Interaction within the Ryanodine Receptor Causes Ca2+ Leak Leading to Catecholaminergic Polymorphic Ventricular Tachycardia.2010
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Masakazu Fukuda, Akihiro Hino, Makoto Ono, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Mechanism of Destabilized RyR2 Channel in Catecholaminergic Polymorphic Ventricular Tachycardia.2010
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
- Organizer
  The 14th Annual Scientific Meeting of the Japanese Heart Failure Society.
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Interruption of Novel Inter-domain Interaction within RyR2 as a Common Therapeutic Target for Channel Stabilization in Heart Failure and CPVT.2010
- Author(s)
  Takeshi Yamamoto, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Masunori Matsuzaki.
- Organizer
  The 74th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Isoform-specific role of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated ca2+ cycling2010
- Author(s)
  Ikeda Y, Aoyama H, Miyazaki Y, Shiraishi K, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M
- Organizer
  19th International Conference of the Cardiovascular System Dynamics Society
- Place of Presentation
  Fukuoka, Centennial Hall Kyushu University School of Medicine
- Data Source
  KAKENHI-PROJECT-21390241
[Presentation] Decreased Affinity of Calmodulin to the Cardiac Ryanodine Receptor Plays a Crucial Role in the CPVT-type Channel Disorder.2010
- Author(s)
  Xiaojuan Xu, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki.
- Organizer
  74th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Isoform-specific role of protein phosphatase 1 catalyticsubunits in sarcoplasmic reticulum mediated ca2+ cycling in cardiomyocytes2010
- Author(s)
  Ikeda Y, Aoyama H, Miyazaki Y, Yoshimura K, Yamamoto T, Yano M, Matsuzaki M
- Organizer
  20th World Congress of the International Society for Heart Research
- Place of Presentation
  Kyoto, Kyoto Internatioal Conference Center
- Data Source
  KAKENHI-PROJECT-21390241
[Presentation] Correction of defective inter-domain interaction within the cardiac ryanodine receptor as a new therapeutic strategy against catecholaminergic polymorphic ventricular tachycardia (CPVT).2009
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Place of Presentation
  札幌,ロイトン札幌
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Mutation-linked channel disorder in catecholaminergic polymorphic ventricular tachycardia(CPVT) is caused by abnormally tight domain-domain interaction in RyR22009
- Author(s)
  Suetomi T, Yano M, Hino A, Ono M, Xu X, Susa T, Uchinoumi H, Oda T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Matsuzaki M
- Organizer
  82nd Scientific Session of American Heart Association
- Place of Presentation
  Orlando, U. S. A.
- Data Source
  KAKENHI-PROJECT-21590932
[Presentation] Correction of Defective Inter-domain Interaction Within the Cardiac Ryanodine Receptor as a New Therapeutic Strategy Against Catecholaminergic Polymorphic Ventricular Tachycardia(CPVT)2009
- Author(s)
  Uchinoumi H, Yano M, Hino A, Suetomi T, Ono M, Xu X, Oda T, Doi M, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2009
- Place of Presentation
  Orlando, USA
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Mutation-linked Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia(CPVT) is Caused by Abnormally Tight Domain-Domain2009
- Author(s)
  Suetomi T, Yano M, Hino A, Ono M, Xu X, Susa T, Uchinoumi H, Oda T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Matsuzaki M
- Organizer
  Interaction in RyR2 American Heart association Scientific meeting 2009
- Place of Presentation
  Orlando, USA
- Year and Date
  2009-11-17
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Low-dose of β Blocker Improves Cardiac Function in Patients With Acute Heart Failure Partly by Inhibiting Ca2+ Leak Through the Ryanodine Receptor.2009
- Author(s)
  Shigeki Kobayashi, Takeo Tanaka, Takehisa Susa, Makoto Ohno, Hitoshi Uchinoumi, Shinichi Okuda, Masahiro Doi, Shuji Kawamura, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Decreased Affinity of Calmodulin to RyR2 May Be a Sauce Mechanism of Leaky Channel in CPVT-associated Mutation2009
- Author(s)
  Xu X, Yano M, Hino A, Suetomi T, Ono M, Uchinoumi H, Oda T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Ohkusa T, Matsuzaki M
- Organizer
  American Heart association Scientific meeting 2009
- Place of Presentation
  Orlando, U. S. A.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Decreased Affinity of Calmodulin to RyR2 May Be a Sauce Mechanism of Leaky Channel in CPVT-associated Mutation.2009
- Author(s)
  Xiaojuan Xu, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Tomoko Ohkusa, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Correction of Defective Inter-domain Interaction Within the Cardiac Ryanodine Receptor as a New Therapeutic Strategy Against Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2009
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Role of Domain(2114-2149) Within RyR2 for Channel Stabilization in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2009
- Author(s)
  Yamamoto T
- Organizer
  Basic Cardiovascular Sciences Annual Conference
- Place of Presentation
  Lake LasVegas, NV, USA
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Low-dose ofβBlocker Improves Cardiac Function in Patients With Acute Heart Failure Partly by Inhibiting Ca^<2+> Leak Through the Ryanodine Receptor2009
- Author(s)
  Kobayashi S, Tanaka T, Susa T, Ono M, Uchinoumi H, Okuda S, Doi M, Kawamura S, Yamamoto T, Yano M, Matsuzaki M.
- Organizer
  American Heart association Scientific meeting 2009
- Place of Presentation
  Orlando, USA
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-22659154
[Presentation] Decreased affinity of calmodulin to RyR2 may be a sauce mechanism of leaky channel in CPVT-associated mutation2009
- Author(s)
  Xu X, Yano M, Hino A, Suetomi T, Ono M, Uchinoumi H, Oda T, Doi M, Okuda S, Kobayashi S, Ikeda Y, Yamamoto T, Ohkusa T, Matsuzaki M
- Organizer
  82nd Scientific Session of American Heart Association
- Place of Presentation
  Orlando, U. S. A.
- Data Source
  KAKENHI-PROJECT-21590932
[Presentation] Mutation-linked Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is Caused by Abnormally Tight Domain-Domain Interaction in RyR2.2009
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Akihiro Hino, Makoto Ohno, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Marked Increase in Spontaneous Ca2+Sparks in Response to b-stimulation as a Critical Cause of Catecholaminergic Polymorphic Ventricular Tachycardia2008
- Author(s)
  山本健
- Organizer
  日本循環器学会
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590777
[Presentation] Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts2008
- Author(s)
  Yamamoto, T, Yano, M, Suedomi, T, Ohno, M, Xu, XJ, Tateishi, H, Okuda, S, Kobayashi, S, Ikeda, Y, Matsuzaki, M
- Organizer
  Basic Cardiovascular Sciences Annual Conference 2009-Molecular Mechanisms of Cardiovascular Disease.
- Place of Presentation
  Keystone, USA
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Abstract 5322 : Mutation-Linked, Defective Inter-Domain Interaction within the Cardiac Ryanodine Receptor as a Critical Cause of2008
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Xu Z, Ono M, Tateishi H, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, and Matsuzaki M
- Organizer
  Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Circulation
- Place of Presentation
  New Orleans、USA(118 : S_526-b)
- Data Source
  KAKENHI-PROJECT-19209030
[Presentation] Domain^<2114-2149> Within RyR2 Plays a Key Role for Correcting Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia(CPVT)2008
- Author(s)
  Yamamoto T
- Organizer
  AHA Scientific Session
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Abstract 5289 : Abnormally Tight Domain-Domain Interaction at Mutation Site Could be a Primary Cause of Catecholaminergic Polymorphic Ventricular Tachycardia : Insight from RyR2^<S2246L/+> Knock-In Mouse2008
- Author(s)
  Suetomi T, Yano M, Xu X, Ono M, Uchinoumi H, Tateishi H, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, and Matsuzaki M
- Organizer
  Model Circulation
- Place of Presentation
  New Orleans、USA(118 : S_520-b)
- Data Source
  KAKENHI-PROJECT-19209030
[Presentation] Abstract 5251 : Defective Inter-domain Interaction May Cause Spontaneous Ca^<2+> Release Via2008
- Author(s)
  Ono M, Yano M, Suetomi T, Xu X, Uchinoumi H, Tateishi H, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, and Matsuzaki M
- Organizer
  Reduced Affinity of Calmodulin Binding to RyR2 in Failing Hearts Circulation
- Place of Presentation
  New Orleans、USA(118 : S_513-d-514S_ -d)
- Data Source
  KAKENHI-PROJECT-19209030
[Presentation] Domain2114-2149 Within RyR2 Plays a Key Role for Correcting Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2008
- Author(s)
  Yamamoto, T, Yano, M, Suedomi, T, Ohno, M, Xu, XJ, Tateishi, H, Okuda, S, Kobayashi, S, Ikeda, Y, Matsuzaki, M
- Organizer
  Scientific Sessions 2008 of American Heart Association
- Place of Presentation
  NewOrleans, USA
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Abstract 5303 : Decreased Affinity of Calmodulin Binding to RyR2 May Cause Leaky Channel in CPVT-Associated Mutation : Insight from RyR2^<R2474s/+> Knock-In Mouse Model2008
- Author(s)
  Xu X, Yano M, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Okuda S, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, and Matsuzaki M
- Organizer
  Circulation
- Place of Presentation
  New Orleans、USA(118 : S_523-a)
- Data Source
  KAKENHI-PROJECT-19209030
[Presentation] Abstract 1533 : Protein Phosphatase 1 Beta is Most Abundan2008
- Author(s)
  Aoyama H, Ikeda Y, Miyazaki Y, Ono M, Yoshimura K, Yamamoto T, Aoki H, Inui M, and Matsuzaki M
- Organizer
  Isoform in the Longitudinal Sarcoplasmic Reticulum and Regulates Phospholamban Phosphorylation in Cardiomyocytes Circulation
- Place of Presentation
  New Orleans、USA(118 : S_345-c-346S_-c)
- Data Source
  KAKENHI-PROJECT-19209030
[Presentation] Dantrolene, A Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia : Insights from a RyR2R2474S/+Knock-in Mouse Model2006
- Author(s)
  Shigeki, Kobayashi, Masafumi, Yano, Hitoshi, Uchinoumi, Xiaojuan, Xu, Makoto, Ohno, Hiroki, Tateishi, Takeshi, Yamamoto, Masunori, Matsuzaki
- Organizer
  Scientific Sessions 2006 of American Heart Association
- Place of Presentation
  Orland
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Correction of Defective Inter-Domain Interacitons within Ryanodine Recepter by Dantrolene may be a Potent Therapeutic Strategy Against Lethal Arrhythmia2006
- Author(s)
  Shigeki, Kobayashi, Masafumi, Yano, Takeshi, Yamamoto, Xu, Xiaojuan, Makoto, Ono, Hitoshi, Uchinoumi, Hiroki, Tateishi, Mamoru, Mochizuki, Toshiyuki, Noma
- Organizer
  Scientific Sessions 2006 of American Heart Association
- Place of Presentation
  Chicago
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[]

1. YANO Masafumi (90294628)

# of Collaborated Projects: 17 results

# of Collaborated Products: 132 results
2. KOBAYASHI Shigeki (90397993)

# of Collaborated Projects: 12 results

# of Collaborated Products: 129 results
3. ODA Tetsuro (40569290)

# of Collaborated Projects: 9 results

# of Collaborated Products: 41 results
4. IKEDA Yasuhiro (00260349)

# of Collaborated Projects: 7 results

# of Collaborated Products: 33 results
5. MATSUZAKI Masunori (60116754)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
6. 青山英和

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 宮崎要介

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 末永弘美 (10372707)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 白石宏造

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 西野静香

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. AOKI Hiroki (60322244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. IZUMI Tomonori (00261694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MAEKAWA Tsuyoshi (60034972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. UEYAMA Tsuyoshi (60380010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 河村修二 (10380007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 河村敦子 (90509530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本直樹 (90448283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
18. 谷健二 (00365420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 藤澤浩一 (00448284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
20. 高見太郎 (60511251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
21. 松本俊彦 (70634723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
22. 永田千鶴 (50299666)

# of Collaborated Projects: 1 results

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23. 澤崎美香 (00761280)

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Yamamoto Takeshi 山本 健

YAMAMOTO Takeshi 山本 健

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A new treatment for heart failure and cardiac hypertrophy by controlling calmodulin translocation into the nucleusPrincipal Investigator

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Novel treatment of arrhythmia and heart failure by controlling the domain of ryanodine receptorsPrincipal Investigator

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Novel therapy of arrhythmia targeting key domain in ryanodine receptorPrincipal Investigator

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Yamamoto Takeshi 山本健

YAMAMOTO Takeshi 山本健