Hirota Tsuyoshi 廣田毅

… Alternative Names

HIROTA Tsuyoshi 広田毅

廣田毅ヒロタツヨシ

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Researcher Number	50372412
Other IDs
Affiliation (Current)	2025: 名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授 2015: 名古屋大学, トランスフォーマティブ生命分子研究所, 准教授 2014: 名古屋大学, トランスフォーマティブ生命分子研究所, 特任准教授 2005 – 2006: 東京大学, 大学院理学系研究科, 拠点形成特任教員 2004 – 2005: 東京大学, 大学院・理学系研究科, 研究拠点形成特任教員
Review Section/Research Field	Principal Investigator Functional biochemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Medium-sized Section 38:Agricultural chemistry and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields / Transformative Research Areas, Section (II) / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / 動物生理・代謝
Keywords	Principal Investigator 概日時計 / ケミカルバイオロジー / 化合物 / 時計タンパク質 / 構造解析 / CRYタンパク質 / PER / 低分子化合物 / タンパク質分解 / CRY … More / 生理機能制御 / 天然変性領域 / 細胞間相互作用 / ケージド化合物 / 選択性 / 振幅 / 薬理学 / 発現制御 / 細胞・組織 / 蛋白質 / 遺伝子 / タンパク質相互作用 / 転写調節 / Bmal1遺伝子 / Per1遺伝子 / Tieg1遺伝子 / グルコース / rat-1細胞 / 位相シフト機構 … More Except Principal Investigator サーカディアンリズム / E4BP4 / MAPK / ケミカルツール / 時計遺伝子 / ガス状シグナル伝達物質 / ヘムオキシゲナーゼ / 概日リズム / ヘム / ポルフィリン / シクロデキストリン / ヘモグロビン / 一酸化炭素 / Peripheral clock / G-protein / Exorhodopsin / Photoreceptive molecule / Suprachiasmatic nucleus / Pineal gland / G11 / BMAL1 / カルシウム結合蛋白質 / p38キナーゼ / カゼインキナーゼ1 / 転写調節 / MAPキナーゼ / 明順応 / ファルネシル化 / 視細胞 / GSK-3β / リン酸化 / クリプトクローム / Bmal1 / TIEG1 / グルコース / Per / ゼブラフィッシュ / CREB / 概日時計 / 末梢時計 / G蛋白質 / エクソロドプシン / 光受容分子 / 視交叉上核 / 松果体 Less

概日リズム創薬に向けたCRYの構造多型性の解明と分子デザインによる機能制御Principal Investigator
- Principal Investigator
  
  廣田毅
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagoya University
独自の機能調節化合物を用いた概日時計システムの分子解剖と革新的な創薬に向けた展開Principal Investigator
- Principal Investigator
  
  廣田毅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Nagoya University
概日時計タンパク質PERを標的とする低分子化合物の開発Principal Investigator
- Principal Investigator
  
  廣田毅
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Nagoya University
革新的な機能調節化合物の創製による概日時計システムの統合的な理解と制御Principal Investigator
- Principal Investigator
  
  廣田毅
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Nagoya University
Photopharmacological regulation of circadian rhythms with caged clock-modulating compounds for investigation of cell-cell interactionsPrincipal Investigator
- Principal Investigator
  
  Hirota Tsuyoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Nagoya University
Mechanistic study on circadian clock system regulated by heme/CO crosstalk
- Principal Investigator
  
  Kitagishi Hiroaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Doshisha University
Development and characterization of small molecules for analysis of circadian rhythm amplitudePrincipal Investigator
- Principal Investigator
  
  Hirota Tsuyoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Nagoya University
Isoform selectivity of circadian clock proteins CRY1 and CRY2 analyzed by new chemical toolsPrincipal Investigator
- Principal Investigator
  
  Hirota Tsuyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Nagoya University
Development and characterization of small molecules that regulate clock protein function for analysis of the circadian clock mechanismPrincipal Investigator
- Principal Investigator
  
  Hirota Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
概日時計タンパク質CRYの機能を調節する低分子化合物Principal Investigator
- Principal Investigator
  
  廣田毅
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
哺乳類の末梢組織における概日時計のグルコース応答Principal Investigator
- Principal Investigator
  
  広田毅 (廣田毅)
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
Molecular, cellular and in vivo analyses of photoresponses and circadian rhythms in animals
- Principal Investigator
  
  FUKADA Yoshitaka
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  動物生理・代謝
- Research Institution
  University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2006 2004 2002

All Journal Article Presentation Book

[Book] Chronobiology and Chronomedicine2024
- Author(s)
  Cornelissen, G. and Hirota, T.
- Total Pages
  716
- Publisher
  Royal Society of Chemistry
- ISBN
  9781839162008
- Data Source
  KAKENHI-PROJECT-20K21269
[Book] Circadian Clocks2022
- Author(s)
  Hirota, T., Hatori, M., and Panda, S
- Total Pages
  429
- Publisher
  Springer Nature
- ISBN
  9781071625767
- Data Source
  KAKENHI-PROJECT-21H04766
[Book] Circadian Clocks2022
- Author(s)
  Hirota, T., Hatori, M., and Panda, S
- Total Pages
  429
- Publisher
  Springer Nature
- ISBN
  9781071625767
- Data Source
  KAKENHI-PROJECT-20K21269
[Book] 実験医学特集『ここまでわかった生物時計の分子ネットワーク』の「時計タンパク質の多段階リン酸化」の項を分担執筆2006
- Author(s)
  広田毅(分担執筆)
- Publisher
  羊土社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104003
[Book] 「時間生物学事典(石田直理雄、本間研一編)」の「血清ショック」の項を執筆2006
- Author(s)
  広田毅
- Publisher
  朝倉書店(印刷中)
- Data Source
  KAKENHI-PROJECT-16770091
[Journal Article] Quo Vadis2024
- Author(s)
  Cornelissen Germaine、Hirota Tsuyoshi
- Journal Title
  
  Chronobiology and Chronomedicine
  
  Volume: 1 Pages: 648-664
- DOI
  10.1039/bk9781839167553-00648
- ISBN
  9781839162008, 9781839167560, 9781839167553
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] Introduction2024
- Author(s)
  Cornelissen Germaine、Otsuka Kuniaki、Hirota Tsuyoshi
- Journal Title
  
  Chronobiology and Chronomedicine
  
  Volume: 1 Pages: 1-11
- DOI
  10.1039/bk9781839167553-00001
- ISBN
  9781839162008, 9781839167560, 9781839167553
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] Development of a novel PET ligand, [11C]GO289 targeting CK2 expressed in the brain2023
- Author(s)
  Ogata Aya、Yamada Takashi、Hattori Saori、Ikenuma Hiroshi、Abe Junichiro、Tada Mari、Ichise Masanori、Suzuki Masaaki、Ito Kengo、Kato Takashi、Amaike Kazuma、Hirota Tsuyoshi、Kakita Akiyoshi、Itami Kenichiro、Kimura Yasuyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 90 Pages: 129327-129327
- DOI
  10.1016/j.bmcl.2023.129327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H02876
[Journal Article] Isoform-selective compounds against mammalian circadian clock proteins CRY1 and CRY22023
- Author(s)
  廣田毅、羽鳥恵
- Journal Title
  
  生化学
  
  Volume: 95 Issue: 5 Pages: 604-608
- DOI
  10.14952/SEIKAGAKU.2023.950604
- ISSN
  0037-1017
- Year and Date
  2023-10-25
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] Regulation of mammalian Cryptochrome with small molecule compounds from in vitro to in vivo2023
- Author(s)
  Hirota Tsuyoshi
- Journal Title
  
  Circadian Clocks
  
  Volume: 1 Pages: 265-281
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] Analysis of the phosphoproteome of CK2α(-/-)/Δα' C2C12 myoblasts compared to the wild-type cells2023
- Author(s)
  Borgo Christian、Cesaro Luca、Hirota Tsuyoshi、Kuwata Keiko、D'Amore Claudio、Ruppert Thomas、Blatnik Renata、Salvi Mauro、Pinna Lorenzo A.
- Journal Title
  
  Open Biology
  
  Volume: 13 Issue: 2 Pages: 220220-220220
- DOI
  10.1098/rsob.220220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] Phosphorylation of RNA Polymerase II by CDKC;2 Maintains the Arabidopsis Circadian Clock Period2022
- Author(s)
  Uehara Takahiro N、Nonoyama Takashi、Taki Kyomi、Kuwata Keiko、Sato Ayato、Fujimoto Kazuhiro J、Hirota Tsuyoshi、Matsuo Hiromi、Maeda Akari E、Ono Azusa、Takahara Tomoaki T、Tsutsui Hiroki、Suzuki Takamasa、Yanai Takeshi、Kay Steve A、Itami Kenichiro、Kinoshita Toshinori、Yamaguchi Junichiro、Nakamichi Norihito
- Journal Title
  
  Plant and Cell Physiology
  
  Volume: 63 Issue: 4 Pages: 450-462
- DOI
  10.1093/pcp/pcac011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05463, KAKENHI-PUBLICLY-20H05411, KAKENHI-PLANNED-20H05910, KAKENHI-PUBLICLY-21H05656, KAKENHI-PROJECT-20H05687, KAKENHI-PROJECT-18H02136, KAKENHI-PROJECT-21H01881, KAKENHI-PROJECT-20K21272, KAKENHI-PROJECT-21K18931, KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins2022
- Author(s)
  Yagi Moeri、Miller Simon、Nagai Yoshiko、Inuki Shinsuke、Sato Ayato、Hirota Tsuyoshi
- Journal Title
  
  F1000Research
  
  Volume: 11 Pages: 1016-1016
- DOI
  10.12688/f1000research.124658.2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] 概日時計の分子機構をケミカルバイオロジーで紐解く2022
- Author(s)
  松田智宏、廣田毅
- Journal Title
  
  化学と生物
  
  Volume: 60 Pages: 212-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04766
[Journal Article] Structural and Chemical Biology Approaches Reveal Isoform-Selective Mechanisms of Ligand Interactions in Mammalian Cryptochromes2022
- Author(s)
  Miller Simon、Hirota Tsuyoshi
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 13 Pages: 837280-837280
- DOI
  10.3389/fphys.2022.837280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy2022
- Author(s)
  Miller Simon、Kesherwani Manish、Chan Priscilla、Nagai Yoshiko、Yagi Moeri、Cope Jamie、Tama Florence、Kay Steve A.、Hirota Tsuyoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 40
- DOI
  10.1073/pnas.2203936119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] Cell-Based Phenotypic Screens to Discover Circadian Clock-Modulating Compounds2022
- Author(s)
  Hatori Megumi、Hirota Tsuyoshi
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2482 Pages: 95-104
- DOI
  10.1007/978-1-0716-2249-0_6
- ISBN
  9781071622483, 9781071622490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] 概日時計の分子機構をケミカルバイオロジーで紐解く2022
- Author(s)
  松田智宏、廣田毅
- Journal Title
  
  化学と生物
  
  Volume: 60 Pages: 212-214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] Comparing the efficacy and selectivity of Ck2 inhibitors. A phosphoproteomics approach2021
- Author(s)
  Borgo Christian、Cesaro Luca、Hirota Tsuyoshi、Kuwata Keiko、D’Amore Claudio、Ruppert Thomas、Blatnik Renata、Salvi Mauro、Pinna Lorenzo A.
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: 214 Pages: 113217-113217
- DOI
  10.1016/j.ejmech.2021.113217
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-18H02402
[Journal Article] Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine2021
- Author(s)
  Zhang M, Kobayashi K, Atsumi H, Katada Y, Nakane Y, Chen J, Nagano R, Kadofusa N, Nishiwaki-Ohkawa T, Kon N, Hirota T, Sato A, Makino T, Yoshimura T
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 21038-21038
- DOI
  10.1038/s41598-021-00499-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05643, KAKENHI-PROJECT-19H03178, KAKENHI-PROJECT-20K20459, KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms2021
- Author(s)
  Kolarski Dusan、Sugiyama Akiko、Rodat Theo、Schulte Albert、Peifer Christian、Itami Kenichiro、Hirota Tsuyoshi、Feringa Ben L.、Szymanski Wiktor
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 10 Pages: 2312-2321
- DOI
  10.1039/d1ob00014d
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-18H02402
[Journal Article] Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock2021
- Author(s)
  Kolarski Dusan、Miller Simon、Oshima Tsuyoshi、Nagai Yoshiko、Aoki Yugo、Kobauri Piermichele、Srivastava Ashutosh、Sugiyama Akiko、Amaike Kazuma、Sato Ayato、Tama Florence、Szymanski Wiktor、Feringa Ben L.、Itami Kenichiro、Hirota Tsuyoshi
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 4 Pages: 2078-2087
- DOI
  10.1021/jacs.0c12280
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-18H02402
[Journal Article] 概日時計を標的とした化合物と創薬の最前線2021
- Author(s)
  飯田夢惟、廣田毅
- Journal Title
  
  Medical Science Digest
  
  Volume: 47 Pages: 23-25
- Data Source
  KAKENHI-PROJECT-21H04766
[Journal Article] Chemical biology of the circadian clock and its application to drug discovery2021
- Author(s)
  廣田毅、松田智宏
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 31 Issue: 2 Pages: 62-67
- DOI
  10.14894/medchem.31.2_62
- NAID
  130008033651
- ISSN
  2432-8618, 2432-8626
- Year and Date
  2021-05-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation2021
- Author(s)
  Miller Simon、Srivastava Ashutosh、Nagai Yoshiko、Aikawa Yoshiki、Tama Florence、Hirota Tsuyoshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 26
- DOI
  10.1073/pnas.2026191118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] 概日時計を標的とした化合物と創薬の最前線2021
- Author(s)
  飯田夢惟、廣田毅
- Journal Title
  
  Medical Science Digest
  
  Volume: 47 Pages: 23-25
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] Reversible modulation of circadian time with chronophotopharmacology2021
- Author(s)
  Kolarski Dusan、Mir-Vinyals Carla、Sugiyama Akiko、Srivastava Ashutosh、Ono Daisuke、Nagai Yoshiko、Iida Mui、Itami Kenichiro、Tama Florence、Szymanski Wiktor、Hirota Tsuyoshi、Feringa Ben L.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3164-3164
- DOI
  10.1038/s41467-021-23301-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-21H02526, KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-20KK0177, KAKENHI-PROJECT-21H04766, KAKENHI-PROJECT-21K19255, KAKENHI-PUBLICLY-21H00307, KAKENHI-PUBLICLY-21H00422
[Journal Article] Structural insights into isoform-selective regulators of mammalian Cryptochromes2021
- Author(s)
  Miller Simon、Hirota Tsuyoshi
- Journal Title
  
  SPring-8 /SACLA Research Frontiers 2020
  
  Volume: - Pages: 22-23
- Open Access
- Data Source
  KAKENHI-PROJECT-21H04766
[Journal Article] Effects of Cryptochrome-modulating compounds on circadian behavioral rhythms in zebrafish2021
- Author(s)
  Iida M, Nakane Y, Yoshimura T, Hirota T
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: Sep Issue: 5 Pages: 501-507
- DOI
  10.1093/jb/mvab096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H05643, KAKENHI-PROJECT-20K20459, KAKENHI-PROJECT-20K21269, KAKENHI-PROJECT-21H04766
[Journal Article] Structural insights into isoform-selective regulators of mammalian Cryptochromes2021
- Author(s)
  Miller Simon、Hirota Tsuyoshi
- Journal Title
  
  SPring-8 /SACLA Research Frontiers 2020
  
  Volume: - Pages: 22-23
- Open Access
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] Small Molecules Modulating Mammalian Biological Clocks: Exciting New Opportunities for Synthetic Chemistry2020
- Author(s)
  Amaike Kazuma、Oshima Tsuyoshi、Skoulding Nicola Stephanie、Toyama Yoshifumi、Hirota Tsuyoshi、Itami Kenichiro
- Journal Title
  
  Chem
  
  Volume: 6 Issue: 9 Pages: 2186-2198
- DOI
  10.1016/j.chempr.2020.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-18H02402
[Journal Article] Isoform-selective regulation of mammalian cryptochromes2020
- Author(s)
  Miller Simon、Son You Lee、Aikawa Yoshiki、Makino Eri、Nagai Yoshiko、Srivastava Ashutosh、Oshima Tsuyoshi、Sugiyama Akiko、Hara Aya、Abe Kazuhiro、Hirata Kunio、Oishi Shinya、Hagihara Shinya、Sato Ayato、Tama Florence、Itami Kenichiro、Kay Steve A.、Hatori Megumi、Hirota Tsuyoshi
- Journal Title
  
  Nature Chemical Biology
  
  Volume: - Issue: 6 Pages: 676-685
- DOI
  10.1038/s41589-020-0505-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19171, KAKENHI-PROJECT-18H02555, KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-17H03653, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18K06316, KAKENHI-PROJECT-19K22693, KAKENHI-PROJECT-19H03266
[Journal Article] 化合物を使って体内時計を操る2020
- Author(s)
  松田智宏、廣田毅
- Journal Title
  
  化学
  
  Volume: 75 Pages: 66-67
- Data Source
  KAKENHI-PROJECT-18H02402
[Journal Article] An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals2020
- Author(s)
  Miller Simon、Aikawa Yoshiki、Sugiyama Akiko、Nagai Yoshiko、Hara Aya、Oshima Tsuyoshi、Amaike Kazuma、Kay Steve A.、Itami Kenichiro、Hirota Tsuyoshi
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27 Issue: 9 Pages: 1192-1198
- DOI
  10.1016/j.chembiol.2020.05.008
- NAID
  120006957723
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-18H02402
[Journal Article] 化合物を使って体内時計を操る2020
- Author(s)
  松田智宏、廣田毅
- Journal Title
  
  化学
  
  Volume: 75 Pages: 66-67
- Data Source
  KAKENHI-PROJECT-20K21269
[Journal Article] A N-terminally deleted form of the CK2α’ catalytic subunit is sufficient to support cell viability2020
- Author(s)
  Borgo Christian、D’Amore Claudio、Cesaro Luca、Itami Kenichiro、Hirota Tsuyoshi、Salvi Mauro、Pinna Lorenzo A.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 531 Issue: 3 Pages: 409-415
- DOI
  10.1016/j.bbrc.2020.07.112
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-18H02402
[Journal Article] “Janus” efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms2020
- Author(s)
  D'Amore Claudio、Moro Enrico、Borgo Christian、Itami Kenichiro、Hirota Tsuyoshi、Pinna Lorenzo A.、Salvi Mauro
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1867 Issue: 11 Pages: 118807-118807
- DOI
  10.1016/j.bbamcr.2020.118807
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-18H02402
[Journal Article] Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing2020
- Author(s)
  Fribourgh Jennifer L、Srivastava Ashutosh、Sandate Colby R、Michael Alicia K、Hsu Peter L、Rakers Christin、Nguyen Leslee T、Torgrimson Megan R、Parico Gian Carlo G、Tripathi Sarvind、Zheng Ning、Lander Gabriel C、Hirota Tsuyoshi、Tama Florence、Partch Carrie L
- Journal Title
  
  eLife
  
  Volume: 9
- DOI
  10.7554/elife.55275
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18K19171
[Journal Article] Pharmacological Interventions to Circadian Clocks and Their Molecular Bases2020
- Author(s)
  Miller Simon、Hirota Tsuyoshi
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: - Issue: 12 Pages: 3498-3514
- DOI
  10.1016/j.jmb.2020.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19171, KAKENHI-PROJECT-18H02402
[Journal Article] 時計遺伝子から考える脳機能と食2019
- Author(s)
  羽鳥恵、廣田毅
- Journal Title
  
  FOOD Style21
  
  Volume: 23 Pages: 80-83
- Data Source
  KAKENHI-PROJECT-18H02402
[Journal Article] Controlling the Circadian Clock with High Temporal Resolution through Photodosing2019
- Author(s)
  Kolarski Dusan、Sugiyama Akiko、Breton Ghislain、Rakers Christin、Ono Daisuke、Schulte Albert、Tama Florence、Itami Kenichiro、Szymanski Wiktor、Hirota Tsuyoshi、Feringa Ben L.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 141 Issue: 40 Pages: 15784-15791
- DOI
  10.1021/jacs.9b05445
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18H02477, KAKENHI-PROJECT-18K19171
[Journal Article] 時計遺伝子から考える脳機能と食2019
- Author(s)
  羽鳥恵、廣田毅
- Journal Title
  
  FOOD Style21
  
  Volume: 23 Pages: 80-83
- Data Source
  KAKENHI-PROJECT-18K19171
[Journal Article] Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen2019
- Author(s)
  Mosser Eric A.、Chiu Cindy N.、Tamai T. Katherine、Hirota Tsuyoshi、Li Suna、Hui May、Wang Amy、Singh Chanpreet、Giovanni Andrew、Kay Steve A.、Prober David A.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 12405-12405
- DOI
  10.1038/s41598-019-48914-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18K19171
[Journal Article] Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ2019
- Author(s)
  Lee Jae Wook、Hirota Tsuyoshi、Ono Daisuke、Honma Sato、Honma Ken-ichi、Park Keunwan、Kay Steve A.
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 4 Pages: 1989-1998
- DOI
  10.1021/acs.jmedchem.8b01541
- NAID
  120006645104
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19171, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18H02477
[Journal Article] Chemical Synthesis of Atomically Tailored SUMO E2 Conjugating Enzymes for the Formation of Covalently Linked SUMO?E2?E3 Ligase Ternary Complexes2019
- Author(s)
  Zhang Yinfeng、Hirota Tsuyoshi、Kuwata Keiko、Oishi Shunsuke、Gramani Subramanian G.、Bode Jeffrey W.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 141 Issue: 37 Pages: 14742-14751
- DOI
  10.1021/jacs.9b06820
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15705, KAKENHI-PROJECT-17H01211, KAKENHI-PROJECT-19H00990, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18K19171
[Journal Article] Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.2019
- Author(s)
  Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.
- Journal Title
  
  Science Advance
  
  Volume: 23 Issue: 1 Pages: 9060-9060
- DOI
  10.1126/sciadv.aau9060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06338, KAKENHI-PROJECT-18K19171, KAKENHI-PLANNED-26119006, KAKENHI-PROJECT-16H04148, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18H02600, KAKENHI-PROJECT-16J04435, KAKENHI-PROJECT-16KT0175, KAKENHI-PROJECT-19K07288, KAKENHI-PLANNED-17H06350, KAKENHI-PUBLICLY-18H04428, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-16K15193
[Journal Article] Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock2019
- Author(s)
  Uehara TN.、Mizutani Y、Kuwata K、Hirota T、Sato A、Mizoi J、Takao S、Matsuo H、Suzuki T、Ito S、Saito AN.、Nishiwaki-Ohkawa T、Yamaguchi-Shinozaki K、Yoshimura T、Kay SA.、Itami K、Kinoshita T、Yamaguchi J、Nakamichi N.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 23 Pages: 11528-11536
- DOI
  10.1073/pnas.1903357116
- NAID
  120006645300
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19229, KAKENHI-PROJECT-19H05463, KAKENHI-ORGANIZER-15H05955, KAKENHI-PLANNED-15H05956, KAKENHI-PUBLICLY-18H04428, KAKENHI-PROJECT-19H05643, KAKENHI-PROJECT-19H00990, KAKENHI-PROJECT-18H02136, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18K19171, KAKENHI-PLANNED-15H05960
[Journal Article] Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks2018
- Author(s)
  Qu Meng、Duffy Tomas、Hirota Tsuyoshi、Kay Steve A.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 52
- DOI
  10.1073/pnas.1816411115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19171, KAKENHI-PROJECT-18H02402
[Journal Article] Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition2018
- Author(s)
  Ashutosh Srivastava, Tsuyoshi Hirota, Stephan Irle and Florence Tama
- Journal Title
  
  Proteins Structure Function and Genetics
  
  Volume: 86 Issue: 3 Pages: 344-353
- DOI
  10.1002/prot.25444
- NAID
  120006477488
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07305, KAKENHI-PLANNED-26119006, KAKENHI-PROJECT-15H05590
[Journal Article] Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies.2017
- Author(s)
  Hatori,M., Gronfier, C., Van Gelder, R.N., Bernstein, P.S., Carreras, J., Panda, S., Marks, F., Sliney, D., Hunt, C.E., Hirota, T., Furukawa, T. and Tsubota, K.
- Journal Title
  
  NPJ Aging Mech. Dis.
  
  Volume: 3 Issue: 1 Pages: 9-9
- DOI
  10.1038/s41514-017-0010-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05590, KAKENHI-PROJECT-16H06174
[Journal Article] Heat shock factors modulate circadian rhythms2016
- Author(s)
  Hirota, T., Fukada, Y.
- Journal Title
  
  Heat Shock Factor (Nakai, A. ed.)
  
  Volume: 1 Pages: 197-209
- DOI
  10.1007/978-4-431-55852-1_10
- ISBN
  9784431558507, 9784431558521
- Data Source
  KAKENHI-PROJECT-15H05590
[Journal Article] Circadian amplitude regulation via FBXW7-targeted REV-ERBa degradation2016
- Author(s)
  Zhao, X., Hirota, T., Han, X., Cho, H., Chong, L., Lamia, K., Liu, S., Atkins, A.R., Banayo, E., Liddle, C., Yu, R.T., Yates III, J.R., Kay, S.A., Downes, M., and Evans, R.M.
- Journal Title
  
  Cell
  
  Volume: 165 Issue: 7 Pages: 1644-1657
- DOI
  10.1016/j.cell.2016.05.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05590
[Journal Article] Identification of small-molecule modulators of the circadian clock.2015
- Author(s)
  Hirota, T. and Kay, S.A.
- Journal Title
  
  Methods Enzymol.
  
  Volume: 551 Pages: 267-282
- DOI
  10.1016/bs.mie.2014.10.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26891011
[Journal Article] Development of small molecule Cryptochrome stabilizer derivatives as modulators of the circadian clock.2015
- Author(s)
  Lee, J.W.*, Hirota, T.*,# (*, equal contribution; #, correspondence), Kumar, A.*,#, Kim, N.J., Irle, S., and Kay, S.A.#
- Journal Title
  
  ChemMedChem
  
  Volume: 10 Issue: 9 Pages: 1489-1497
- DOI
  10.1002/cmdc.201500260
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05590
[Journal Article] C-H Activation Generates Period-Shortening Moleculaes That Target Cryptochrome in the Mammalian Circadian Clock.2015
- Author(s)
  Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Okawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irie S, Kay SA, Yoshimura T, Itami K.
- Journal Title
  
  Angew Chem Int Ed
  
  Volume: 54 Issue: 24 Pages: 7193-7197
- DOI
  10.1002/anie.201502942
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04683, KAKENHI-PROJECT-15H05590, KAKENHI-PROJECT-13J03280, KAKENHI-PROJECT-25708005, KAKENHI-PROJECT-26650033, KAKENHI-PROJECT-26000013
[Journal Article] Tokeipanpakushitsu no Tadankairinsanka2006
- Author(s)
  Tsuyoshi Hirota et al.
- Journal Title
  
  Jikken Igaku Vol.24, No.4
  
  Pages: 452-459
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104003
[Journal Article] 時計タンパク質の多段階リン酸化2006
- Author(s)
  広田毅
- Journal Title
  
  実験医学 24・4
  
  Pages: 452-459
- Data Source
  KAKENHI-PROJECT-16770091
[Journal Article] Resetting mechanism of central and peripheral circadian clocks in mammals.2004
- Author(s)
  Tsuyoshi Hirota
- Journal Title
  
  Zool.Sci. 21
  
  Pages: 359-368
- NAID
  110006282406
- Data Source
  KAKENHI-PROJECT-14104003
[Journal Article] Resetting mechanism of central and peripheral circadian clocks in mammals.2004
- Author(s)
  Tsuyoshi Hirota
- Journal Title
  
  Zool. Sci. 21
  
  Pages: 359-368
- NAID
  110006282406
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104003
[Journal Article] Resetting mechanism of central and peripheral circadian clocks in mammals2004
- Author(s)
  Tsuyoshi Hirota
- Journal Title
  
  Zoological Science 21・4
  
  Pages: 359-368
- NAID
  110006282406
- Data Source
  KAKENHI-PROJECT-16770091
[Journal Article] Resetting mechanism of central and peripheral circadian clocks in mammals2004
- Author(s)
  Tsuyoshi Hirota et al.
- Journal Title
  
  Zool.Sci. 21
  
  Pages: 359-368
- NAID
  110006282406
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104003
[Journal Article] Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts.2002
- Author(s)
  Tsuyoshi Hirota
- Journal Title
  
  J. Biol. Chem. 277
  
  Pages: 44244-44251
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104003
[Journal Article] Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured rat-1 fibroblasts2002
- Author(s)
  Tsuyoshi Hirota et al.
- Journal Title
  
  J.Biol.Chem. 277
  
  Pages: 44244-44251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104003
[Presentation] 時計タンパク質CRYの機能制御化合物と構造ダイナミクス2023
- Author(s)
  廣田　毅
- Organizer
  1.日本睡眠学会第45回定期学術集会・第30回日本時間生物学会学術大会合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21269
[Presentation] Regulation of mammalian Cryptochrome with small molecule compounds from in vitro to in vivo2022
- Author(s)
  Hirota Tsuyoshi
- Organizer
  Sapporo Symposium on Biological Rhythm 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269
[Presentation] Regulation of mammalian Cryptochrome with small molecule compounds from in vitro to in vivo2022
- Author(s)
  Hirota Tsuyoshi
- Organizer
  Sapporo Symposium on Biological Rhythm 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04766
[Presentation] 低分子化合物を用いた概日時計タンパク質の機能制御の最先端2021
- Author(s)
  廣田　毅
- Organizer
  日本睡眠学会第46回定期学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21269
[Presentation] Chemical biology of the circadian clock and its potential to improve health2021
- Author(s)
  Tsuyoshi Hirota
- Organizer
  The 94th Japanese Biochemical Society Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-21H04766
[Presentation] Isoform-selective compounds for mammalian CRY proteins2021
- Author(s)
  Tsuyoshi Hirota
- Organizer
  5th Asian Forum on Chronobiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04766
[Presentation] Chemical biology of the circadian clock and its potential to improve health2021
- Author(s)
  Tsuyoshi Hirota
- Organizer
  The 94th Japanese Biochemical Society Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-20K21269
[Presentation] 哺乳類の階層時計システムの理解に向けた時計タンパク質の調節化合物の開発2021
- Author(s)
  廣田　毅
- Organizer
  第28回日本時間生物学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04766
[Presentation] Isoform-selective compounds for mammalian CRY proteins2021
- Author(s)
  Tsuyoshi Hirota
- Organizer
  5th Asian Forum on Chronobiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21269
[Presentation] 低分子化合物を用いた概日時計タンパク質の機能制御の最先端2021
- Author(s)
  廣田　毅
- Organizer
  日本睡眠学会第46回定期学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04766
[Presentation] 哺乳類の階層時計システムの理解に向けた時計タンパク質の調節化合物の開発2021
- Author(s)
  廣田　毅
- Organizer
  第28回日本時間生物学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21269
[Presentation] 時計タンパク質に作用する低分子化合物の開発2020
- Author(s)
  廣田　毅
- Organizer
  第41回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] Reversible Control of the Circadian Period by Photoswitchable Longdaysin2020
- Author(s)
  Tsuyoshi Hirota, Dusan Kolarski, Akiko Sugiyama, Wiktor Szymanski, and Ben L. Feringa
- Organizer
  Socirty for Research on Biological Rhythms 2020 Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] 時計タンパク質に作用する低分子化合物の開発2020
- Author(s)
  廣田　毅
- Organizer
  第41回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21269
[Presentation] Small molecule modulators of the circadian clock function2020
- Author(s)
  Tsuyoshi Hirota
- Organizer
  日本薬理学会　第93回年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] Small molecule modulators of the circadian clock function2020
- Author(s)
  Tsuyoshi Hirota
- Organizer
  日本薬理学会　第93回年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] Small molecule modulators of mammalian clock proteins2019
- Author(s)
  Tsuyoshi Hirota
- Organizer
  2019 CIBR Beijing Conference on Brain & Behavior
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] 概日時計タンパク質を標的とする低分子化合物2019
- Author(s)
  廣田　毅
- Organizer
  2019年度BINDS公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] 概日時計タンパク質を標的とする低分子化合物2019
- Author(s)
  廣田　毅
- Organizer
  2019年度BINDS公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] 体内時計を調節する化合物の探索2019
- Author(s)
  廣田　毅
- Organizer
  日本農芸化学会2019年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] Chemical and structural biology approach for circadian biochemistry of clock proteins2019
- Author(s)
  Tsuyoshi Hirota
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] 哺乳類CRYタンパク質のアイソフォーム選択的な制御2019
- Author(s)
  廣田　毅
- Organizer
  第2回構造生命科学研究会
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] 哺乳類CRYタンパク質のアイソフォーム選択的な制御2019
- Author(s)
  廣田　毅
- Organizer
  第2回構造生命科学研究会
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] 構造生物学とケミカルバイオロジーの融合による概日時計の創薬研究2019
- Author(s)
  廣田　毅
- Organizer
  蛋白研セミナー第1回構造生命科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] Chemical and structural biology approach for circadian biochemistry of clock proteins2019
- Author(s)
  Tsuyoshi Hirota
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] 構造生物学とケミカルバイオロジーの融合による概日時計の創薬研究2019
- Author(s)
  廣田　毅
- Organizer
  蛋白研セミナー第1回構造生命科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] 体内時計を調節する化合物の探索2019
- Author(s)
  廣田　毅
- Organizer
  日本農芸化学会2019年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] 新規の概日リズム調節化合物の同定とがん細胞増殖に対する効果2019
- Author(s)
  廣田　毅
- Organizer
  第2回がんと代謝研究会若手の会
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] 新規の概日リズム調節化合物の同定とがん細胞増殖に対する効果2019
- Author(s)
  廣田　毅
- Organizer
  第2回がんと代謝研究会若手の会
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] Small molecule modulators of mammalian clock proteins2019
- Author(s)
  Tsuyoshi Hirota
- Organizer
  2019 CIBR Beijing Conference on Brain & Behavior
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] Dissecting mammalian clock mechanism with chemical tools2018
- Author(s)
  Hirota, T.
- Organizer
  International Symposium on Biological Rhythms
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] Identification of CRY1/CRY2 selective compounds2018
- Author(s)
  Hirota, T.
- Organizer
  2018 Society for Research on Biological Rhythm Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] Identification of CRY1/CRY2 selective compounds2018
- Author(s)
  Aikawa, Y. Kay, S.A., Hirota, T.
- Organizer
  12th Annual Salk Institute, Fondation IPSEN, and Science Symposium on Biological Complexity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] Identification of CRY1/CRY2 selective compounds2018
- Author(s)
  Hirota, T.
- Organizer
  2018 Society for Research on Biological Rhythm Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] Dissecting mammalian clock mechanism with chemical tools2018
- Author(s)
  Hirota, T.
- Organizer
  International Symposium on Biological Rhythms
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] ケミカルバイオロジーを応用した哺乳類の概日時計のメカニズム解析2018
- Author(s)
  廣田　毅
- Organizer
  第3回先端ケミカルバイオロジー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K19171
[Presentation] ケミカルバイオロジーを応用した哺乳類の概日時計のメカニズム解析2018
- Author(s)
  廣田　毅
- Organizer
  第3回先端ケミカルバイオロジー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02402
[Presentation] Chemical and structural biology approaches to understand molecular mechanism underlying 24-hour period of mammalian circadian clock2017
- Author(s)
  Hirota, T.
- Organizer
  第55回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] Dissecting design principal of biological clock by using chemical tools2017
- Author(s)
  Hirota, T.
- Organizer
  MANA International Symposium 2017
- Place of Presentation
  Tsukuba
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] ケミカルバイオロジーによる24時間の創出原理の分子研究2017
- Author(s)
  廣田　毅
- Organizer
  第24回日本時間生物学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] Chemical regulation of the molecular clock2016
- Author(s)
  Hirota, T.
- Organizer
  The 29th Conference of the International Society for Chronobiology
- Place of Presentation
  Suzhou, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] 化学と生物学の融合による時間生物学研究2016
- Author(s)
  廣田　毅
- Organizer
  第23回日本時間生物学会学術大会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] 哺乳類の概日時計分子のケミカルバイオロジーと構造生物学2015
- Author(s)
  廣田　毅
- Organizer
  蛋白研セミナー「第６回　神経科学と構造生物学の融合研究会」
- Place of Presentation
  岡崎
- Year and Date
  2015-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] クロノネットワークとケミカルバイオロジー2015
- Author(s)
  廣田　毅
- Organizer
  第120回日本解剖学会・第92回日本生理学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-03-22
- Invited
- Data Source
  KAKENHI-PROJECT-26891011
[Presentation] Identification of small Molecule Modulators of the Mammalian Circadian Clock.2015
- Author(s)
  Hirota, T.
- Organizer
  The 1st CSRS-ITbM Joint Workshop
- Place of Presentation
  Nagoya
- Year and Date
  2015-01-07
- Invited
- Data Source
  KAKENHI-PROJECT-26891011
[Presentation] Chrono-nutrition研究における細胞ベースのハイスループットアッセイ2015
- Author(s)
  廣田　毅
- Organizer
  第22回日本時間生物学会学術大会
- Place of Presentation
  東京
- Year and Date
  2015-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-15H05590
[Presentation] 概日時計タンパク質CRYのFAD結合ポケットに作用する低分子化合物の発見2015
- Author(s)
  廣田　毅
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H05590

1. FUKADA Yoshitaka (80165258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. KOJIMA Daisuke (60376530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Kitagishi Hiroaki (60448090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岡野俊行 (40272471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 和田恭高 (90376559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 天池一真 (00866600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITAMI Kenichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. SATO Ayato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUWATA Keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 仲村厚志

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Jeffery Bode

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHKAWA Taeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. NAKAMICHI Norihito

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 吉村崇

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 中根右介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. TAMA FLORENCE

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 大石俊輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 八木田和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 土谷佳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirota Tsuyoshi 廣田 毅

HIROTA Tsuyoshi 広田 毅

廣田 毅 ヒロタ ツヨシ

Research Projects

Research Products

Co-Researchers

概日リズム創薬に向けたCRYの構造多型性の解明と分子デザインによる機能制御Principal Investigator

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独自の機能調節化合物を用いた概日時計システムの分子解剖と革新的な創薬に向けた展開Principal Investigator

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概日時計タンパク質PERを標的とする低分子化合物の開発Principal Investigator

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革新的な機能調節化合物の創製による概日時計システムの統合的な理解と制御Principal Investigator

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Photopharmacological regulation of circadian rhythms with caged clock-modulating compounds for investigation of cell-cell interactionsPrincipal Investigator

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Mechanistic study on circadian clock system regulated by heme/CO crosstalk

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Development and characterization of small molecules for analysis of circadian rhythm amplitudePrincipal Investigator

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Isoform selectivity of circadian clock proteins CRY1 and CRY2 analyzed by new chemical toolsPrincipal Investigator

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Development and characterization of small molecules that regulate clock protein function for analysis of the circadian clock mechanismPrincipal Investigator

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概日時計タンパク質CRYの機能を調節する低分子化合物Principal Investigator

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哺乳類の末梢組織における概日時計のグルコース応答Principal Investigator

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Molecular, cellular and in vivo analyses of photoresponses and circadian rhythms in animals

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[Book] Chronobiology and Chronomedicine2024

Author(s)

Hirota Tsuyoshi 廣田毅

HIROTA Tsuyoshi 広田毅

廣田毅ヒロタツヨシ

[Book] 実験医学特集『ここまでわかった生物時計の分子ネットワーク』の「時計タンパク質の多段階リン酸化」の項を分担執筆2006

[Book] 「時間生物学事典(石田直理雄、本間研一編)」の「血清ショック」の項を執筆2006