Hanashima Shinya 花島慎弥

… Alternative Names

HANASHIMA Shinya 花島慎弥

花島慎弥ハナシマシンヤ

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Researcher Number	50373353
Other IDs	https://orcid.org/0000-0003-3102-7890
Affiliation (Current)	2025: 鳥取大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 鳥取大学, 工学研究科, 教授 2022: 大阪大学, 大学院理学研究科, 准教授 2020 – 2021: 大阪大学, 理学研究科, 准教授 2016 – 2019: 大阪大学, 理学研究科, 講師 2016: 理化学研究所, 糖鎖構造生物学研究チーム, 研究員 … More 2013 – 2016: 大阪大学, 理学(系)研究科(研究院), 講師 2012: 独立行政法人理化学研究所, 糖鎖構造生物学研究チーム, 基幹研究所研究員 2008 – 2010: The Institute of Physical and Chemical Research, 糖鎖構造生物学研究チーム, 基幹研究所研究員 2005: 理研, 研究員 2004: 独立行政法人理化学研究所, 伊藤細胞制御化学研究室, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Living organism molecular science / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Biomolecular chemistry Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Medium-sized Section 38:Agricultural chemistry and related fields / Biomolecular chemistry / Physical pharmacy / Chemical biology
Keywords	Principal Investigator NMR / 合成 / 糖脂質 / 脂質ラフト / 有機合成 / ガングリオシド / コレステロール / 相互作用 / 糖鎖 / MSスペクトル … More / FRET / 蛍光寿命測定 / 固体NMR / 重水素 / DSC / スフィンゴ糖脂質 / リポソーム / 顕微鏡 / 構造 / 生体膜 / ＮＭＲ / タンパク質 / 神経突起伸長 / グリコシル化 / Siglec-2 / シアル酸 / 二基質 / N-アセチルグルコサミン / 酵素阻害剤 / 糖転移酵素 … More Except Principal Investigator 脂質ラフト / 脂質二重膜 / 平均配向 / 固体NMR / 立体配座 / 脂肪鎖 / 細胞表面修飾 / PtdGlc / 超臨界流体クロマトグラフィー / グリコシル化 / 糖化リン脂質 / 同位体標識脂質 / 脂肪鎖の指組構造 / 非対称脂質二重膜 / 糖脂質 / 生体モデル膜 / 動的配座 / 古細菌脂質 / ドメイン構造 / スフィンゴミエリン / DCIR2 / CLEC-2 / GnT-III / バイセクトGlcNAc / N型糖鎖 / PIM / ZG16p / DCIR / PHA-E / Calsepa / 大量発現 / 気相電気泳動法 / βグルカン / Dectin-1 / 立体構造 / 分子動力学 / Ｘ線結晶構造解析 / 相互作用 / 分枝構造 / NMR / ダイナミクス / レクチン / 糖鎖 / 重水素固体ＮＭＲ / 表面プラズモン共鳴 / 重水素固体NMR / 小分子プローブ / コレステロール Less

Novel method for synthesis of Phosphatidylglucoside: applied to cell surface glycosylation
- Principal Investigator
  
  松尾一郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Gunma University
Average orientation of lipid acyl chains in the domain structure of model membranes
- Principal Investigator
  
  村田道雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
植物特有のスフィンゴ脂質の構造と相互作用が誘起する脂質ラフトの描像の構築Principal Investigator
- Principal Investigator
  
  花島慎弥
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Tottori University
Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions
- Principal Investigator
  
  村田道雄
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Osaka University
Elucidation of the formation mechanism on glycolipid-protein assemblages in lipid raftsPrincipal Investigator
- Principal Investigator
  
  Hanashima Shinya
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Tottori University
  Osaka University
Dynamic conformation and domain structure of lipid molecules in model biomembranes
- Principal Investigator
  
  MURATA Michio
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Lipid interaction and headgroup conformation of glycosphingolipids in membrane bilayerPrincipal Investigator
- Principal Investigator
  
  Hanashima Shinya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Osaka University
Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids
- Principal Investigator
  
  Murata Michio
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical biology
- Research Institution
  Osaka University
Structural analysis of asymmetrically branched glycans
- Principal Investigator
  
  Yamaguchi Yoshiki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Institute of Physical and Chemical Research
Structure and interaction analysis of GPI-related glycansPrincipal Investigator
- Principal Investigator
  
  HANASHIMA Shinya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Osaka University
  The Institute of Physical and Chemical Research
Chemical synthesis of unique AG-gangliosides and evaluations of nerve cell stimulation activitiesPrincipal Investigator
- Principal Investigator
  
  HANASHIMA Shinya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
N-アセチルグルコサミン転移酵素V阻害剤を指向した二基質型アナログ化合物の合成Principal Investigator
- Principal Investigator
  
  花島慎弥
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research

[Book] Glycoscience: Biology and Medicine Indirect detection of hydroxy proton exchange through deuterium-induced 13C-NMR isotope shifts2014
- Author(s)
  Hanashima, S.and Yamaguchi, Y.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25460054
[Journal Article] Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids2023
- Author(s)
  Ondevilla Joan Candice、Hanashima Shinya、Mukogawa Akane、Miyazato Darcy Garza、Umegawa Yuichi、Murata Michio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1865 Issue: 5 Pages: 184145-184145
- DOI
  10.1016/j.bbamem.2023.184145
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17993, KAKENHI-PROJECT-21H04707
[Journal Article] Passive Translocation of Phospholipids in Asymmetric Model Membranes: Solid-State 1H NMR Characterization of Flip-Flop Kinetics Using Deuterated Sphingomyelin and Phosphatidylcholine2023
- Author(s)
  Watanabe Hirofumi、Hanashima Shinya、Yano Yo、Yasuda Tomokazu、Murata Michio
- Journal Title
  
  Langmuir
  
  Volume: 39 Issue: 43 Pages: 15189-15199
- DOI
  10.1021/acs.langmuir.3c01650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17993, KAKENHI-PROJECT-21H04707
[Journal Article] Dynamic assembly and interaction of glycosphingolipids in cholesterol-containing model membranes2023
- Author(s)
  Shinya Hanashima, Mikito Nakano, Michio Murata
- Journal Title
  
  Pure and Applied Chemistry
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05713
[Journal Article] Molecular Dynamics of Glycolipids in Liposomes2023
- Author(s)
  Yasuda Tomokazu、Slotte J. Peter、Murata Michio、Hanashima Shinya
- Journal Title
  
  Methods in molecular biology
  
  Volume: 2613 Pages: 257-270
- DOI
  10.1007/978-1-0716-2910-9_19
- ISBN
  9781071629093, 9781071629109
- Open Access
- Data Source
  KAKENHI-PROJECT-19K05713
[Journal Article] NMR Studies on the Structure and Functions of Small Biomolecules with Highly Flexible Conformation2023
- Author(s)
  Murata Michio、Umegawa Yuichi、Hanashima Shinya
- Journal Title
  
  Bulletin of the Chemical Society of Japan
  
  Volume: 96 Issue: 10 Pages: 1156-1168
- DOI
  10.1246/bcsj.20230166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K17373, KAKENHI-PROJECT-21H04707
[Journal Article] Dynamic assembly and interaction of glycosphingolipids in cholesterol-containing model membranes2023
- Author(s)
  Hanashima Shinya、Nakano Mikito、Murata Michio
- Journal Title
  
  Pure and Applied Chemistry
  
  Volume: 95 Issue: 9 Pages: 971-977
- DOI
  10.1515/pac-2023-0204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K17993, KAKENHI-PROJECT-21H04707
[Journal Article] Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study2022
- Author(s)
  Umegawa Yuichi、Yamamoto Tomoya、Dixit Mayank、Funahashi Kosuke、Seo Sangjae、Nakagawa Yasuo、Suzuki Taiga、Matsuoka Shigeru、Tsuchikawa Hiroshi、Hanashima Shinya、Oishi Tohru、Matsumori Nobuaki、Shinoda Wataru、Murata Michio
- Journal Title
  
  Science Advances
  
  Volume: 8 Issue: 24 Pages: 2658-2658
- DOI
  10.1126/sciadv.abo2658
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19115, KAKENHI-PROJECT-20H00405, KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-20K05730
[Journal Article] Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers2022
- Author(s)
  Hanashima Shinya、Ikeda Ryuji、Matsubara Yuki、Yasuda Tomokazu、Tsuchikawa Hiroshi、Slotte J. Peter、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 121 Issue: 7 Pages: 1143-1155
- DOI
  10.1016/j.bpj.2022.02.037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-20K05730, KAKENHI-PROJECT-21H04707
[Journal Article] Fluorescence Spectroscopic Analysis of Lateral and Transbilayer Fluidity of Exosome Membranes2022
- Author(s)
  Yasuda Tomokazu, Watanabe Hirofumi, Hirosawa Koichiro, Suzuki Kenichi , Suga Keishi, Hanashima Shinya
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 48 Pages: 14695-14703
- DOI
  10.1021/acs.langmuir.2c02258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04628, KAKENHI-PROJECT-20H03225, KAKENHI-PROJECT-21H02424, KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-22K05329, KAKENHI-PROJECT-23K23111
[Journal Article] Behavior of Triterpenoid Saponin Ginsenoside Rh2 in Ordered and Disordered Phases in Model Membranes Consisting of Sphingomyelin, Phosphatidylcholine, and Cholesterol2022
- Author(s)
  Garza Darcy Lacanilao、Hanashima Shinya、Umegawa Yuichi、Murata Michio、Kinoshita Masanao、Matsumori Nobuaki、Greimel Peter
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 34 Pages: 10478-10491
- DOI
  10.1021/acs.langmuir.2c01261
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19115, KAKENHI-PROJECT-20H00405, KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-19K05713
[Journal Article] Lipid chain-driven interaction of a lipidated Src-family kinase Lyn with the bilayer membrane2022
- Author(s)
  Hanashima Shinya、Mito Kanako、Umegawa Yuichi、Murata Michio、Hojo Hironobu
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 20 Issue: 32 Pages: 6436-6444
- DOI
  10.1039/d2ob01079h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04707, KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-23K23464
[Journal Article] FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers2021
- Author(s)
  Nakano Mikito、Hanashima Shinya、Hara Toshiaki、Kabayama Kazuya、Asahina Yuya、Hojo Hironobu、Komura Naoko、Ando Hiromune、Nyholm Thomas K.M.、Slotte J. Peter、Murata Michio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1863 Issue: 8 Pages: 183623-183623
- DOI
  10.1016/j.bbamem.2021.183623
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05275, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18H03942, KAKENHI-PROJECT-21H04707
[Journal Article] β-Glucosylation of cholesterol reduces sterol-sphingomyelin interactions2021
- Author(s)
  Hanashima Shinya、Fukuda Nanami、Malabed Raymond、Murata Michio、Kinoshita Msanao、Greimel Peter、Hirabayashi Yoshio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1863 Issue: 2 Pages: 183496-183496
- DOI
  10.1016/j.bbamem.2020.183496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-19K22257, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-21H04707
[Journal Article] Heavy Atom Detergent/Lipid Combined X-ray Crystallography for Elucidating the Structure-Function Relationships of Membrane Proteins2021
- Author(s)
  Shinya Hanashima, Takanori Nakane, Eiichi Mizohata*
- Journal Title
  
  Membranes (Basel)
  
  Volume: 11(11) Issue: 11 Pages: 823-823
- DOI
  10.3390/membranes11110823
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05780, KAKENHI-PROJECT-19K05713
[Journal Article] Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin.2020
- Author(s)
  Raymond Malabed, Shinya Hanashima, Michio Murata, Kaori Sakurai
- Journal Title
  
  Langmuir
  
  Volume: 36 Issue: 13 Pages: 3600-3610
- DOI
  10.1021/acs.langmuir.9b03957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-18K05331
[Journal Article] Enantiomers of phospholipids and cholesterol: A key to decipher lipid‐lipid interplay in membrane2020
- Author(s)
  Hanashima Shinya、Yano Yo、Murata Michio
- Journal Title
  
  Chirality
  
  Volume: 32 Issue: 3 Pages: 282-298
- DOI
  10.1002/chir.23171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713
[Journal Article] Sphingomyelins and ent-Sphingomyelins Form Homophilic Nano-Subdomains within Liquid Ordered Domains2020
- Author(s)
  Yano Yo、Hanashima Shinya、Tsuchikawa Hiroshi、Yasuda Tomokazu、Slotte J. Peter、London Erwin、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 119 Issue: 3 Pages: 539-552
- DOI
  10.1016/j.bpj.2020.06.028
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PLANNED-17H06406, KAKENHI-PROJECT-16H06315
[Journal Article] Efficient diversification of GM3 gangliosides via late-stage sialylation and dynamic glycan structural studies with 19F solid-state NMR2020
- Author(s)
  Takahashi Maina、Shirasaki Junya、Komura Naoko、Sasaki Katsuaki、Tanaka Hide-Nori、Imamura Akihiro、Ishida Hideharu、Hanashima Shinya、Murata Michio、Ando Hiromune
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 18 Issue: 15 Pages: 2902-2913
- DOI
  10.1039/d0ob00437e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-20K15412, KAKENHI-PROJECT-18H03942, KAKENHI-PROJECT-19K23627
[Journal Article] Side-chain deuterated cholesterol as a molecular probe to determine membrane order and cholesterol partitioning2019
- Author(s)
  Hanashima Shinya、Ibata Yuki、Watanabe Hirofumi、Yasuda Tomokazu、Tsuchikawa Hiroshi、Murata Michio
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 37 Pages: 8601-8610
- DOI
  10.1039/c9ob01342c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-16H06315
[Journal Article] The Perpendicular Orientation of Amphotericin B Methyl Ester in Hydrated Lipid Bilayers Supports the Barrel-Stave Model2019
- Author(s)
  Yamamoto Tomoya、Umegawa Yuichi、Yamagami Masaki、Suzuki Taiga、Tsuchikawa Hiroshi、Hanashima Shinya、Matsumori Nobuaki、Murata Michio
- Journal Title
  
  Biochemistry
  
  Volume: 印刷中 Issue: 17 Pages: 2282-2291
- DOI
  10.1021/acs.biochem.9b00180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol2019
- Author(s)
  Cornelio Kimberly、Espiritu Rafael Atillo、Hanashima Shinya、Todokoro Yasuto、Malabed Raymond、Kinoshita Masanao、Matsumori Nobuaki、Murata Michio、Nishimura Shinichi、Kakeya Hideaki、Yoshida Minoru、Matsunaga Shigeki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Biomembranes
  
  Volume: 1861 Issue: 1 Pages: 228-235
- DOI
  10.1016/j.bbamem.2018.07.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19149, KAKENHI-PLANNED-17H06401, KAKENHI-PLANNED-17H06406, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-16H06315, KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-15H03121, KAKENHI-PROJECT-26221204
[Journal Article] Cholesterol-Induced Conformational Change in the Sphingomyelin Headgroup2019
- Author(s)
  Hanashima Shinya、Murakami Kazuhiro、Yura Michihiro、Yano Yo、Umegawa Yuichi、Tsuchikawa Hiroshi、Matsumori Nobuaki、Seo Sangjae、Shinoda Wataru、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 117 Issue: 2 Pages: 307-318
- DOI
  10.1016/j.bpj.2019.06.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05713, KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Amphotericin B-Ergosterol Complex Spans a Lipid Bilayer as a Single-Length Assembly.2019
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Kosuke Funahashi, Sangjae Seo, Wataru Shinoda, Michio Murata.
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 51 Pages: 5188-5196
- DOI
  10.1021/acs.biochem.9b00835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-18K19149
[Journal Article] Bisecting GlcNAc restricts conformations of branches in model N -glycans with GlcNAc termini2018
- Author(s)
  Hanashima Shinya、Suga Akitsugu、Yamaguchi Yoshiki
- Journal Title
  
  Carbohydrate Research
  
  Volume: 456 Pages: 53-60
- DOI
  10.1016/j.carres.2017.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01801, KAKENHI-PROJECT-16H04758
[Journal Article] Sphingomyelin Stereoisomers Reveal That Homophilic Interactions Cause Nanodomain Formation2018
- Author(s)
  Yano Yo、Hanashima Shinya、Yasuda Tomokazu、Tsuchikawa Hiroshi、Matsumori Nobuaki、Kinoshita Masanao、Al Sazzad Md. Abdullah、Slotte J. Peter、Murata Michio
- Journal Title
  
  Biophysical Journal
  
  Volume: 115 Issue: 8 Pages: 1530-1540
- DOI
  10.1016/j.bpj.2018.08.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19149, KAKENHI-PROJECT-16H06315, KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-15H03121
[Journal Article] Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3- O -glycosyl saponins2017
- Author(s)
  Malabed Raymond、Hanashima Shinya、Murata Michio、Sakurai Kaori
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1859 Issue: 12 Pages: 2516-2525
- DOI
  10.1016/j.bbamem.2017.09.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06315, KAKENHI-PROJECT-15K01801
[Journal Article] Distinct roles for each N-glycan branch interacting with mannose-binding type Jacalin-related lectins Orysata and Calsepa.2017
- Author(s)
  Nagae M, Mishra SK, Hanashima S, Tateno H, Yamaguchi Y
- Journal Title
  
  Glycobiology
  
  Volume: 27(12) Issue: 12 Pages: 1120-1133
- DOI
  10.1093/glycob/cwx081
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07303, KAKENHI-PROJECT-16H05071, KAKENHI-PROJECT-15K01801, KAKENHI-PROJECT-16H04758
[Journal Article] Synthesis and Th1-immunostimulatory activity of α-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chain2016
- Author(s)
  Md. Imran Hossain, Shinya Hanashima, Takuto Nomura, Sebastien Lethu, Hiroshi Tsuchikawa, Michio Murata, Hiroki Kusaka, Shunsuke Kita, Katsumi Maenaka
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 16 Pages: 3687-3695
- DOI
  10.1016/j.bmc.2016.06.007
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J01933, KAKENHI-PROJECT-15K01801
[Journal Article] The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores2016
- Author(s)
  Yasuo Nakagawa, Yuichi Umegawa, Naohiro Matsushita, Tomoya Yamamoto, Hiroshi Tsuchikawa, Shinya Hanashima, Tohru Oishi, Nobuaki Matsumori, Michio Murata
- Journal Title
  
  Biochemistry
  
  Volume: 55 Issue: 24 Pages: 3392-3402
- DOI
  10.1021/acs.biochem.6b00193
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-15H03121, KAKENHI-PROJECT-16H06315
[Journal Article] Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins2016
- Author(s)
  Nagae M, Kanagawa M, Morita-Matsumoto K, Hanashima S, Kizuka Y, Taniguchi N, Yamaguchi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 (22973) Issue: 1 Pages: 1-11
- DOI
  10.1038/srep22973
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460054, KAKENHI-PROJECT-15K18496, KAKENHI-PUBLICLY-26110724, KAKENHI-PROJECT-15H04700, KAKENHI-PLANNED-26117008
[Journal Article] Crystal structure of human dendritic cell inhibitory receptor (DCIR) C-type lectin domain reveals the binding mode with N-glycan2016
- Author(s)
  Nagae M, Ikeda A, Hanashima S, Kojima T, Matsumoto N, Yamamoto K, Yamaguchi Y.
- Journal Title
  
  FEBS Lett.
  
  Volume: Mar 26 Issue: 8 Pages: 1-9
- DOI
  10.1002/1873-3468.12162
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460054, KAKENHI-PUBLICLY-26110724, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-15K18496, KAKENHI-PROJECT-16H04758
[Journal Article] Defining the interaction of human soluble lectin ZG16p and mycobacterial phosphatidylinositol mannosides2015
- Author(s)
  1.Shinya Hanashima, Sebastian Götze, Yan Liu, Akemi Ikeda, Kyoko Kojima-Aikawa, Naoyuki Taniguchi, Daniel Varón Silva, Ten Feizi, Peter H. Seeberger, Yoshiki Yamaguchi
- Journal Title
  
  ChemBioChem
  
  Volume: 16 Issue: 10 Pages: 1502-11
- DOI
  10.1002/cbic.201500103
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24710257, KAKENHI-PROJECT-25460054, KAKENHI-PROJECT-15H04700, KAKENHI-PLANNED-26117008
[Journal Article] Axial Hydrogen at C7 Position and Bumpy Tetracyclic Core Markedly Reduce Sterol’s Affinity to Amphotericin B in Membrane2015
- Author(s)
  Nakagawa, Y., Umegawa, Y., Nonomura, K., Matsushita, N., Takano, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N., and Murata, M.
- Journal Title
  
  Biochemistry
  
  Volume: 54 Issue: 2 Pages: 303-312
- DOI
  10.1021/bi5012942
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J01527, KAKENHI-PROJECT-25750383, KAKENHI-PUBLICLY-26102527, KAKENHI-PROJECT-25242073
[Journal Article] Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane.2015
- Author(s)
  Yamamoto, T., Umegawa, Y., Tsuchikawa, H., Matsumori, N., Hanashima, S., Murata, M., Haser, R., Rawlings, B. J., Caffrey, P.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 17 Pages: 5782-5788
- DOI
  10.1016/j.bmc.2015.07.009
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-15H03121
[Journal Article] NMR study of short β(1-3)-glucans provides insights into the structure and interaction with Dectin-1.2014
- Author(s)
  Hanashima S, Ikeda A, Tanaka H, Adachi Y, Ohno N, Takahashi T, Yamaguchi Y.
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: 31 Issue: 3 Pages: 199-207
- DOI
  10.1007/s10719-013-9510-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710257, KAKENHI-PROJECT-25460054
[Journal Article] Structural Basis for Multiple Sugar Recognition of Jacalin-Related Human ZG16p Lectin2014
- Author(s)
  Kanagawa, M., Liu, Y., Hanashima, S., Ikeda, A., Chai, W., Nakano, Y., Kojima-Aikawa, K., Feizi, T., and Yamaguchi, Y.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(24) Issue: 24 Pages: 16954-65
- DOI
  10.1074/jbc.m113.539114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460054
[Journal Article] Phytohemagglutinin from Phaseolus vulgaris (PHA-E) displays a novel glycan recognition mode using a common legume lectin fold2014
- Author(s)
  M. Nagae, K. Soga, K. Morita-Matsumoto,　S. Hanashima, A. Ikeda, K. Yamamoto, and Y. Yamaguchi
- Journal Title
  
  Glycobiology
  
  Volume: 24 Issue: 4 Pages: 368-78
- DOI
  10.1093/glycob/cwu004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460054
[Journal Article] Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III2014
- Author(s)
  2.Shinya Hanashima, Hiroaki Korekane, Naoyuki Taniguchi, Yoshiki Yamaguchi
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 24 Issue: 18 Pages: 4533-4537
- DOI
  10.1016/j.bmcl.2014.07.074
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24710257, KAKENHI-PROJECT-25460054, KAKENHI-PROJECT-26440051
[Journal Article] Recognition of Bisecting N-Acetylglucosamine: Structural basis for asymmetric interaction with the mouse lectin dendritic cell inhibitory receptor 22013
- Author(s)
  Masamichi Nagae
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 47 Pages: 33598-33610
- DOI
  10.1074/jbc.m113.513572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24770102, KAKENHI-PROJECT-24770111, KAKENHI-PUBLICLY-25121730, KAKENHI-PROJECT-25460054
[Journal Article] NMR study into the mechanism of recognition of the degree of polymerization by oligo/polysialic acid antibodies.2013
- Author(s)
  Hanashima S, Sato C, Tanaka H, Takahashi T, Kitajima K, Yamaguchi Y.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 19 Pages: 6069-76
- DOI
  10.1016/j.bmc.2013.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570133, KAKENHI-PUBLICLY-24110506, KAKENHI-PROJECT-25460054
[Journal Article] Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid : insight into the binding preference for polysialic acid.2013
- Author(s)
  Nagae M, Ikeda A, Halle M, Hanashima S, Kitajima K, Sato C, Yamaguchi Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Issue: 47 Pages: 33784-33796
- DOI
  10.1074/jbc.m113.496224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J00256, KAKENHI-PROJECT-23570133, KAKENHI-PUBLICLY-24110506, KAKENHI-PUBLICLY-24110520, KAKENHI-PROJECT-25460054
[Journal Article] Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques2011
- Author(s)
  花島慎弥
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 18 Pages: 3720-3725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques2010
- Author(s)
  Shinya Hanashima, Ken-ichi Sato, Yuko Naito, Hiromu Takematsu, Yasunori Kozutsumi, Yukishige Ito, Yoshiki Yamaguchi
- Journal Title
  
  Bioorg. Med. Chem. 18
  
  Pages: 3720-3725
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Synthesis of the starfish ganglioside LLG-3 tetrasaccharide2009
- Author(s)
  Shinya Hanashima, Daichi Ishikawa, Shoji Akai, Ken-ichi Sato
- Journal Title
  
  Carbohydr. Res. 344
  
  Pages: 747-752
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Synthesis of the starfish ganglioside AG-2 pentasaccharide2009
- Author(s)
  Shinya Hanashima, Yoshiki Yamaguchi, Yukishige Ito, Ken-ichi Sato
- Journal Title
  
  Tetrahedron Lett. 50
  
  Pages: 6150-6153
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Silylene/oxazolidinone double-locked sialic acid building blocks for the efficient sialylation reaction in dichloromethane2009
- Author(s)
  Shinya Hanashima, Ken-ichi Sato, Yukishige Ito, Yoshiki Yamaguchi
- Journal Title
  
  Eur.J.Org.Chem.
  
  Pages: 4215-4220
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Silylene/Oxazolidinone Double-Locked Sialic Acid Building Blocks for Efficient Sialylation Reactions in Dichloromethane2009
- Author(s)
  Shinya Hanashima
- Journal Title
  
  European Journal of Organic Chemistry
  
  Pages: 4215-4220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Homogeneous glycoprotein synthesis using bacterial oligosaccharyltransferase2009
- Author(s)
  Shinya Hanashima
- Journal Title
  
  Trends in Glycoscience and Glycotechnology 21
  
  Pages: 302-304
- NAID
  10026977089
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Synthesis of the starfish ganglioside AG2 pentasaccharide2009
- Author(s)
  Shinya Hanashima
- Journal Title
  
  Tetrahedron Letters 50
  
  Pages: 6150-6153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Sialylation using N-glycolylneuraminyl phosphite donors to synthesize Neu5Gc-containing glycans2009
- Author(s)
  Shinya Hanashima
- Journal Title
  
  Carbohydrate Research 344
  
  Pages: 959-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Sialylation Reactions Using N-Glycolylneuraminic Acid Phosphite Donor2009
- Author(s)
  Shinya Hanashima, Taku Tomiya, Shoji Akai, Ken-ichi Sato
- Journal Title
  
  Carbohydr. Res. 344
  
  Pages: 959-965
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Synthesis of the starfish ganglioside LLG-3 tetrasaccharide2009
- Author(s)
  花島慎弥
- Journal Title
  
  Carbohydrate Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Homogeneous glycoprotein synthesis using bacterial oligosaccharyltransferase2009
- Author(s)
  Shinya Hanashima
- Journal Title
  
  Trend in Glycosci. GlycoTech. 21
  
  Pages: 302-304
- NAID
  10026977089
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Thioester-assisted α-sialylation reaction2008
- Author(s)
  花島慎弥
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 5111-5114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Thioester-assisted .-sialylation reaction2008
- Author(s)
  Shinya Hanashima, Shoji Akai, Ken-ichi Sato
- Journal Title
  
  Tetrahedron Lett. 49
  
  Pages: 5111-5114
- Data Source
  KAKENHI-PROJECT-20710171
[Journal Article] Synthesis of a Bisubstrate-Type Inhibitor of N-acetylglucosaminyltransferasess2004
- Author(s)
  Shinya Hanashima
- Journal Title
  
  Angewante Chemie International Edition 43
  
  Pages: 5674-5677
- Data Source
  KAKENHI-PROJECT-16710165
[Journal Article] Recent strategies for stereoselective sialylation reaction and their applications
- Author(s)
  Shinya Hanashima
- Journal Title
  
  Trend in Glycosci. GlycoTech.
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] 固体NMRを用いた脂質膜上のラクトシルセラミドドメインと病原菌糖鎖の相互作用解析2023
- Author(s)
  花島慎弥、Won Je Kang、佐々木克聡、村田道雄、安達禎之
- Organizer
  第42回日本糖質学会
- Data Source
  KAKENHI-PROJECT-23K17993
[Presentation] 表面プラズモン共鳴法を利用したインテグリンとGM3糖鎖間の相互作用の解析2023
- Author(s)
  花島慎弥、岸水際、佐々木克聡、村田道雄、鈴木健一
- Organizer
  第42回日本糖質学会
- Data Source
  KAKENHI-PROJECT-23K17993
[Presentation] 固体NMR測定による膜環境におけるガングリオシドGM3糖鎖の配座・配向解析2023
- Author(s)
  佐々木克聡, 花島慎弥,　梅川雄一, 村田道雄,　李秀栄, 水口賢司
- Organizer
  日本ケミカルバイオロジー学会　第17回年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] Conformation of the Ganglioside GM3 Glycan in Lipid Bilayers as Elucidated by Solid-State NMR2022
- Author(s)
  Katsuaki Sasaki, Suyong Re, Yuichi Umegawa, Michio Murata, Shinya Hanashima
- Organizer
  第30回国際糖質会議　ICS2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] ガングリオシドGM3糖鎖とインテグリンの相互作用のSPR解析2022
- Author(s)
  岸水際、花島慎弥、村田道雄、鈴木健一
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 体NMR測定による脂質膜環境におけるガングリオシドGM3糖鎖の配座・配向解析2022
- Author(s)
  佐々木克聡, 梅川雄一, 村田道雄, 花島慎弥, 李秀栄, 水口賢司
- Organizer
  第41回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 生体モデル膜におけるSrcファミリーキナーゼLyn脂質アンカー鎖の動態解析2022
- Author(s)
  水戸佳奈子、花島慎弥、梅川雄一、村田道雄、北條裕信
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] Investigation of Inner Leaflet Lipids Influence on Sphingomyelin Domain2022
- Author(s)
  Liao, C-H., Hanashima, S., Yasuda, T., Murata, M.
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 表裏の脂質構成が異なる脂質二重層におけるコリン脂質の内外葉比の定量的評価2022
- Author(s)
  渡辺宏史、花島慎弥、安田智一、村田道雄
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 脂質膜近傍のGlycoscience; 糖脂質の脂質膜における構造と相互作用を介した機能の解明を目指して2022
- Author(s)
  花島慎弥
- Organizer
  第41回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] ガングリオシドGM3糖鎖とインテグリンの相互作用のSPR解析2022
- Author(s)
  岸水際、花島慎弥、村田道雄、鈴木健一
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 固体NMRを用いた脂質膜環境におけるガングリオシドGM3糖鎖の立体構造解析2022
- Author(s)
  佐々木克聡、梅川雄一、村田道雄、花島慎弥
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] Lipid interactions of the triterpenoid saponin ginsenoside Rh2 in membranes containing cholesterol and sphingomyelin2022
- Author(s)
  Darcy Lacanilao Garza, Shinya Hanashima, Ayana Yamanaka, Yuichi Umegawa, Michio Murata, Masanao Kinoshita, Nobuaki Matsumori, Peter Greimel
- Organizer
  日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] ガングリオシドGM3糖鎖とインテグリンの相互作用のSPR解析2022
- Author(s)
  岸水際、花島慎弥、村田道雄、鈴木健一
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 生体モデル膜におけるSrcファミリーキナーゼLyn脂質アンカー鎖の動態解析2022
- Author(s)
  水戸佳奈子、花島慎弥、梅川雄一、村田道雄、北條裕信
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 表裏の脂質構成が異なる脂質二重層におけるコリン脂質の内外葉比の定量的評価2022
- Author(s)
  渡辺宏史、花島慎弥、安田智一、村田道雄
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 表裏の脂質構成が異なる脂質二重層におけるコリン脂質の内外葉比の定量的評価2022
- Author(s)
  渡辺宏史、花島慎弥、安田智一、村田道雄
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Conformation of the Ganglioside GM3 Glycan in Lipid Bilayers as Elucidated by Solid-State NMR2022
- Author(s)
  Katsuaki Sasaki, Suyong Re, Yuichi Umegawa, Michio Murata, Shinya Hanashima
- Organizer
  第30回国際糖質会議 ICS2022（国際学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] 生体モデル膜におけるSrcファミリーキナーゼLyn脂質アンカー鎖の動態解析2022
- Author(s)
  水戸佳奈子、花島慎弥、梅川雄一、村田道雄、北條裕信
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] Investigation of Inner Leaflet Lipids Influence on Sphingomyelin Domain.2022
- Author(s)
  Liao, C-H., Hanashima, S., Yasuda, T., Murata, M.
- Organizer
  日本化学会第102春季年会
- Data Source
  KAKENHI-PROJECT-21H04707
[Presentation] Dynamic Assembly and Interaction of Glycosphingolipids in Cholesterol-Containing Model Membranes2022
- Author(s)
  Shinya Hanashima, Michio Murata
- Organizer
  第30回国際糖質会議　ICS2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 体NMR測定による脂質膜環境におけるガングリオシドGM3糖鎖の配座・配向解析2022
- Author(s)
  佐々木克聡, 梅川雄一, 村田道雄, 花島慎弥,　李秀栄, 水口賢司
- Organizer
  第41回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] Elucidation of inter-leaflet coupling in asymmetric membranes induced by very long chain sphingomyelin based on solid-state NMR2021
- Author(s)
  Keeratisakulsith, T., Umegawa, Y., Tsuchikawa, H., Hanashima, S., Murata, M., Shinoda, W.
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 蛍光スフィンゴ脂質プローブを用いたモデル膜中でのスフィンゴ脂質ドメイン構造のFRET解析2021
- Author(s)
  友田千尋、矢野陽、花島慎弥、河村奈緒子、安藤弘宗、村田道雄、London, E.
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with Cholesterol2021
- Author(s)
  Ondevilla, J. C., Hanashima, S., Umegawa, Y., Murata, M.
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Membrane interaction and disrupting activity of the triterpenoid saponin ginsenoside Rh2 to cholesterol and sphingomyelin-containing liposomes2021
- Author(s)
  Garza, D, L., Murata, M., Hanashima, S.
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] ガングリオシドGM3糖鎖と結合タンパク質の親和性を制御する脂質間相互作用の解明2021
- Author(s)
  佐々木克聡、花島慎弥、梅川雄一、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] EGF受容体膜貫通ドメインとガングリオシドGM3の側方相互作用のFRET解析における膜脂質の影響評価2021
- Author(s)
  中野幹人、花島慎弥、原利明、樺山一哉、河村奈緒子、安藤弘宗、Nyholm, T., Slotte, P., 村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素固体NMRを用いた相分離二重膜中のLo/Ld相脂質組成の定量的解析2021
- Author(s)
  山中彩菜、花島慎弥、井端悠貴、梅川雄一、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 膜脂質成分に依存したGM3糖鎖コンホメーションの固体NMR解析2021
- Author(s)
  佐々木克聡, 梅川雄一, 村田道雄, 花島慎弥
- Organizer
  日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 水和脂質膜の固体NMR測定による高度不飽和脂肪酸結合リン脂質の分子機構の解明2021
- Author(s)
  大田英和、梅川雄一、花島慎弥、土川博史、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 表裏の脂質組成の異なる二重膜リポソームにおけるコレステロール内外葉分布の解明2021
- Author(s)
  渡辺宏史、花島慎弥、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] ガングリオシドGM3糖鎖と結合タンパク質の親和性を制御する脂質間相互作用の解明2021
- Author(s)
  佐々木克聡、花島慎弥、梅川雄一、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 脂質分子の膜環境下での構造と相互作用の解明2021
- Author(s)
  花島　慎弥
- Organizer
  大阪大学蛋白質研究所セミナー
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 表裏の脂質組成の異なる二重膜リポソームにおけるコレステロール内外葉分布の解明2021
- Author(s)
  渡辺宏史、花島慎弥、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] EGF受容体膜貫通ドメインとガングリオシドGM3の側方相互作用のFRET解析における膜脂質の影響評価2021
- Author(s)
  中野幹人、花島慎弥、原利明、樺山一哉、河村奈緒子、安藤弘宗、Thomas Nyholm、Peter Slotte、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 蛍光スフィンゴ脂質プローブを用いたモデル膜中でのスフィンゴ脂質ドメイン構造のFRET解析2021
- Author(s)
  友田千尋、矢野陽、花島慎弥、河村奈緒子、安藤弘宗、村田道雄、Erwin London
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 重水素固体NMRを用いた相分離二重膜中のLo/Ld相脂質組成の定量的解析2021
- Author(s)
  山中彩菜、花島慎弥、井端悠貴、梅川雄一、村田道雄
- Organizer
  日本化学会第101春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] スフィンゴミエリン蛍光プローブのFRET測定を用いたモデル膜における脂質ナノドメイン構造の解明2020
- Author(s)
  友田　千尋・矢野　陽・花島　慎弥・村田　道雄・London　Erwin
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 特異な糖脂質コレステリル-β-グルコシドのモデル膜における脂質間相互作用の解明2020
- Author(s)
  福田　奈那美・花島　慎弥・Raymond　Malabed・村田　道雄・Peter　Greimel・平林　義雄
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] Evaluation of lateral interactions between membrane gangliosides and receptor transmembrane segments in lipid bilayers based on semi-quantitative fluorescence analysis2020
- Author(s)
  NAKANO, Mikito; HANASHIMA, Shinya; HARA, Toshiaki; KABAYAMA, Kazuya; FUKASE, Koichi; MURATA, Michio; ANDO, Hiromune; SUZUKI, Kenichi G. N.; SLOTTE, J. Peter
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] スフィンゴミエリン蛍光プローブのFRET測定を用いたモデル膜における脂質ナノドメイン構造の解明2020
- Author(s)
  友田千尋、矢野陽、花島慎弥、村田道雄、London Erwin
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Evaluation of lateral interactions between membrane gangliosides and receptor transmembrane segments in lipid bilayers based on semi-quantitative fluorescence analysis2020
- Author(s)
  NAKANO, Mikito; HANASHIMA, Shinya; HARA, Toshiaki; KABAYAMA, Kazuya; FUKASE, Koichi; MURATA, Michio; ANDO, Hiromune; SUZUKI, Kenichi G. N.; SLOTTE, J. Peter
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] Cholesterol effect on the membrane activities of the diosgenyl saponins2020
- Author(s)
  ONDEVILLA, Joan Candice; HANASHIMA, Shinya; MURATA, Michio
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 脂質膜上で形成されるラクトシルセラミドの強固なドメインの固体NMR解析2020
- Author(s)
  松原　侑輝・池田　竜二・花島　慎弥・村田　道雄
- Organizer
  日本化学会第100春季年会
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 脂質膜上で形成されるラクトシルセラミドの強固なドメインの固体NMR解析2020
- Author(s)
  松原侑輝、池田竜二、花島慎弥、村田　道雄
- Organizer
  日本化学会第100春季年会 (2020)
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 非対称膜におけるスフィンゴミエリンとコレステロールの脂質間相互作用の固体NMR解析2019
- Author(s)
  矢野陽、花島慎弥、土川博史、村田道雄、London Erwin
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Glycosphingolipid-lipid Interactions and Domain Formation in Model Bilayer Membranes2019
- Author(s)
  Shinya HANASHIMA, Michio MURATA
- Organizer
  25th International Symposium on Glycoconjugates
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05713
[Presentation] 水和脂質膜中での高度不飽和脂肪酸脂質の運動性解析2019
- Author(s)
  大田英和，梅川雄一, 花島慎弥, 土川博史, 村田道雄
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Synthesis of novel 13C, 2H-labeled Amphotericin B and the conformational analysis of glycosidic linkage in lipid bilayers.2019
- Author(s)
  Yamamoto, T., Umegawa, Y., Suzuki, T., Tsuchikawa, H., Hanashima, S., Murata, M., Matsumori, N., Seo, S., Funahashi, K., Shinoda, W.
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 新規コレステロール側鎖重水素標識体の開発とそれを用いた三成分膜での相状態の解明2019
- Author(s)
  井端悠貴、花島慎弥、安田智一、土川博史、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 表裏の脂質組成が異なる二重膜リポソームの調製と表裏の秩序化の観測2019
- Author(s)
  渡辺宏史・矢野陽・花島慎弥・安田智一・村田道雄・Erwin London
- Organizer
  第9回CSJ化学フェスタ2019
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 脂質膜環境における糖鎖の配向解析を目指したガングリオシドGM3頭部重水素標識体の合成2019
- Author(s)
  佐々木克聡、花島慎弥、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 混合脂質モデル膜におけるラクトシルセラミドの強固なドメインの固体NMR解析2019
- Author(s)
  松原侑輝、花島慎弥、池田竜二、村田道雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Interaction of ganglioside with the EGF receptor transmembrane segments in model membrane.2019
- Author(s)
  Nakano, M., Hanashima, S., Hara, T., Murata, M., Kabayama, K., Fukase, K., Ando, H., Suzuki, K., Slotte, P.
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素標識化脂質を用いた流動相における相分離二重膜の精密 NMR 解析2019
- Author(s)
  山中彩菜, 井端悠貴, 土川博史, 花島慎弥, 村田道雄
- Organizer
  第9回CSJ化学フェスタ2019
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 脳内新規糖脂質コレステリル-β-グルコシドのモデル膜における脂質間相互作用の解明2019
- Author(s)
  福田奈那美、花島慎弥、Malabed Raymond、村田道雄、Greimel Peter、平林義雄
- Organizer
  日本化学会第99春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 生体モデル膜中におけるコレステロール依存的な糖鎖の配向変化の解明を目指したガングリオシドGM3標識体の合成研究2018
- Author(s)
  佐々木克聡・花島慎弥・村田道雄
- Organizer
  日本化学会98春年会
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] Cholesterol Interaction with Steroidal Saponins in Bilayer Membrane.2018
- Author(s)
  Hanashima, S., Malabed R., Murata M.
- Organizer
  ICPAC2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Analysis of the raft-like nanodomains using sphingomyelin antipode2018
- Author(s)
  Yano Yo、Hanashima Shinya、Yasuda Tomokazu、Tsuchikawa Hiroshi、Murata Michio、Kinoshita Masanao、Matsumori Nobuaki、Suzuki Kenichi、J. Peter. Slotte、Erwin London
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 生体モデル膜中におけるグルコシルセラミド頭部の固体NMR配向解析2018
- Author(s)
  石井亮・花島慎弥・梅川雄一・村田道雄
- Organizer
  日本化学会98春年会
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] ガングリオシドGM1とスフィンゴミエリンが形成するドメイン構造の動的解析2018
- Author(s)
  大野詩織・花島慎弥・安田智一・土川博史・村田道雄・木下祥尚・松森信明・安藤弘宗・鈴木健一・J. Peter Slotte
- Organizer
  日本化学会98春年会
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] Cholesterol Interaction with Steroidal Saponins in Bilayer Membrane2018
- Author(s)
  Shinya Hanashima, Malabed Raymond, Michio Murata
- Organizer
  ICPAC2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] アンフォテリシンBとステロールが形成するチャネル複合体の構造研究2018
- Author(s)
  山本智也、梅川雄一、中川泰男、鈴木大河、山上正輝、土川博史、花島慎弥、村田道雄、松森信明、Seo Sangjaed、篠田渉
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Sterol-dependent membrane activity of steroidal saponin OSW-1 using spectroscopic and microscopic approaches2018
- Author(s)
  Malabed Raymond、Hanashima Shinya、Murata Michio、Sakurai Kaori
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Cholesterol Interaction with Steroidal Saponins in Bilayer Membrane2018
- Author(s)
  Hanashima Shinya、Malabed Raymond、Murata Michio
- Organizer
  ICPAC2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 生体膜モデル中におけるラクトシルセラミドの脂質間相互作用とドメイン形成の解析2017
- Author(s)
  花島慎弥、池田竜二、村田道雄、J Peter Slotte
- Organizer
  第36回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] コレステロール側鎖の重水素標識体の合成とLo/Ld相による運動性変化と分配比の解明2017
- Author(s)
  井端悠貴、花島慎弥、安田智一、村田道雄
- Organizer
  第7回CSJ化学フェスタ
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Cholesterol interaction and membrane-permeabilizing properties of OSW-1 examined by solid-state NMR and fluorescence microscopy2017
- Author(s)
  Malabed Raymond、Hanashima Shinya、Murata Michio、Sakurai Kaori
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Membrane behavior and sterol interactions of sphigomyelin antipode2017
- Author(s)
  Yano Yo、Hanashima Shinya、Yasuda Tomokazu、Tuchikawa Hiroshi、Murata Michio、Kinoshita Masanao、Matumori Nobuaki、Suzuki Kenichi、Slotte J. Peter
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素固体NMRと蛍光分光法を用いたラクトシルセラミドとコレステロールの生体モデル膜中での相互作用解析2017
- Author(s)
  池田竜二、土川博史、花島慎弥、J. Peter Slotte、村田道雄
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶応義塾大学
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] 蛍光分光法を用いた生体モデル膜中におけるガングリオシドGM3とタンパク質EGFR膜貫通ドメインの相互作用解析2017
- Author(s)
  中野幹人、花島慎弥、原利明、村田道雄、樺山一哉、深瀬浩、安藤弘宗、木曽真、鈴木健一
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶応義塾大学
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] 脂質膜中でのグルコシルセラミド頭部基の配向解析を目指したフッ素化アナログ化合物の合成研究2017
- Author(s)
  石井亮、花島慎弥、村田道雄
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  慶応義塾大学
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] Solid state NMR study for the molecular orientation of amphotericin B in membrane2017
- Author(s)
  Yamamoto Tomoya、Umegawa Yuichi、Yamagami Masaki、Hanashima Shinya、Tsuchikawa Hiroshi、Matsumori Nobuaki、Murata Michio
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] スフィンゴミエリン鏡像体を用いたラフトモデル膜中での脂質間相互作用解析2017
- Author(s)
  矢野陽、花島慎弥、土川博史、村田道雄、木下祥尚、松森信明、J. Peter Slotte
- Organizer
  日本ケミカルバイオロジー学会第12回年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 固体NMRを用いた脂質二重膜におけるスフィンゴミエリン頭部の動的な配座解析2017
- Author(s)
  村上量弘、花島慎弥、梅川雄一、土川史、村田道雄、松森信明、J. Peter Slotte
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Enantioselective total synthesis of purple membrane lipid PGP-Me toward elucidation of protein- lipid interactions2017
- Author(s)
  Yamagami Masaki、Cui Jin、Tsuchikawa Hiroshi、Umegawa Yuichi、Hanashima Shinya、Murata Michio
- Organizer
  日本化学会第97春季年会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Design and Synthesis of CD1d Ligands for Precise Binding Mode Investigation of Ligand-Bound CD1d.2016
- Author(s)
  HOSSAIN, Md. Imran; HANASHIMA, Shinya; TSUCHIKAWA, Hiroshi; MURATA
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Design and Synthesis of Heavy Atom Labelled GalCers for X-ray Co-crystalization with CD1d.2016
- Author(s)
  Md. Imran Hossain, Shinya Hanashima, Hiroshi Tsuchikawa, Michio Murata,
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  大阪
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] レクチンを利用したN-結合型糖鎖の準安定構造の解析2016
- Author(s)
  山口芳樹、長江雅倫、花島慎弥
- Organizer
  第17回若手NMR研究会in箱根
- Place of Presentation
  箱根高原ホテル（神奈川県足柄下郡）
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-25460054
[Presentation] 重水素固体NMR測定における水和二重膜の温度測定のための金属錯体の合成と評価2016
- Author(s)
  下西剛史、梅川雄一、門司真美、花島慎弥、土川博史、村田道雄
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] Solid state NMR study for the glycosphingolipid interactions in raft model membrane2016
- Author(s)
  Shinya Hanashima
- Organizer
  1st BMS conference
- Place of Presentation
  Berlin, Germany
- Year and Date
  2016-11-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] Chemical Approach to Fishing New Binding Proteins with the Ladder shaped Polyether Yessotoxin.2016
- Author(s)
  YEUNG, Clarisse1; TSUCHIKAWA, Hiroshi; HANASHIMA, Shinya; MATSUMORI, Nobuaki; MURATA, Michio
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 脂質ラフトにおけるスフィンゴミエリン頭部の動的挙動解析のための重水素標識体の合成2016
- Author(s)
  村上量弘・花島慎弥・土川博史・松森信明・村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Characterization of the Binding Proteins with the Ladder-shaped Polyether, Yessotoxin, through Magnetic Beads Pull-Down Assay.2016
- Author(s)
  YEUNG, Clarisse; HAYASHI, Kanako; KURNIATI, Dian; TSUCHIKAWA, Hiroshi; HANASHIMA, Shinya; MATSUMORI, Nobuaki; MURATA, Michio
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  大阪
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] スフィンゴミエリンのアシル鎖における深度依存的な融解現象の観測2016
- Author(s)
  門司真美・土川博史・花島慎弥・安田智一・村田道雄・松森信明・Slotte J. Peter
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] ガングリオシドGM1 およびスフィンゴミエリンが共存するリン脂質膜におけるドメイン形成の蛍光イメージング解明2016
- Author(s)
  高田美沙、花島慎弥、土川博史、安田智一、村田道雄、木下祥尚、松森信明、安藤弘宗、木曽真、鈴木健一、楠見明弘、J. Peter Slotte
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] Acyl chain mobility of Glycosphingolipids in Hydrated Membrane as Examined by Solid State 2H NMR2016
- Author(s)
  Shinya Hanashima, Ryuji Ikeda, Shiori Ohno, Michio Murata
- Organizer
  27th International Conference on Magnetic Resonance in Biological Systems (ICMRBS)
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] ガングリオシドGM1 およびスフィンゴミエリンが共存するリン脂質膜におけるドメイン形成の蛍光イメージング解明2016
- Author(s)
  高田美沙・花島慎弥・土川博史・安田智一・村田道雄・木下祥尚・松森信明・安藤弘宗・木曽真・鈴木健一・楠見明弘・J. Peter Slotte
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Microdomain formation in sphingomyelin antipode-containing membrane for investigating lipid-lipid interactions2016
- Author(s)
  YANO, Yo; HANASHIMA, Shinya; TSUCHIKAWA, Hiroshi; YASUDA, Tomokazu; KINOSHITA, Masanao; MATSUMORI, Nobuaki; MURATA, Michio; SUZUKI, Kenichi; KUSUMI, Akihiro
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 水和脂質二重膜の固体NMR 測定のための化学シフト温度計の開発2016
- Author(s)
  下西剛史・梅川雄一、花島慎弥、土川博史、村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 重水素標識スフィンゴ糖脂質の合成と生体モデル膜における固体NMR 解析2016
- Author(s)
  南角拓実・花島慎弥・村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Sterol recognition mechanism of saponins deduced from membrane-permeabilizing activities and spectroscopic evidence.2016
- Author(s)
  MALABED, Raymond; HANASHIMA, Shinya; MURATA, Michio; SAKURAI, Kaori
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] アンフォテリシンBのチャネル形成機構解明を目指した構造活性相関研究2016
- Author(s)
  山本智也、梅川雄一、土川博史、松森信明、花島慎弥、村田道雄、Resul Hauser、Bernard J. Rawlings、Patrick Caffrey
- Organizer
  日本薬学会　第１３６回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 極長鎖スフィンゴミエリンの脂質モデル膜に与える影響と相挙動解析2016
- Author(s)
  森内舞・土川博史・花島慎弥・安田智一・村田道雄・松森信明・Slotte J. Peter
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Glycan dynamics analysed by combined NMR and X-ray crystallography2016
- Author(s)
  Yamaguchi Y, Nagae M, Hanashima S
- Organizer
  8th ACGG Annual Conference
- Place of Presentation
  Wuxi, China
- Year and Date
  2016-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460054
[Presentation] 2H,19F NMRを用いた脂質膜中におけるアンフォテリシンBの配向解析2016
- Author(s)
  山本智也、梅川雄一、山上正輝、花島慎弥、土川博史、松森信明、村田道雄
- Organizer
  第55回NMR討論会
- Data Source
  KAKENHI-PROJECT-16H06315
[Presentation] 重水素標識スフィンゴ糖脂質の合成と生体モデル膜における固体NMR 解析2016
- Author(s)
  南角拓実、花島慎弥、村田道雄
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] スフィンゴミエリン鏡像体で構成したラフトモデル膜の膜物性と脂質相互作用2015
- Author(s)
  矢野陽、花島慎弥、土川博史、村田道雄、木下祥尚、松森信明、J Peter Slotte
- Organizer
  日本ケミカルバイオロジー学会第10回年会
- Place of Presentation
  仙台
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 生体膜における資質間の相互作用解明に向けた糖脂質標識体の合成とNMR測定2015
- Author(s)
  花島慎弥、南角拓実、池田竜二、村田道雄
- Organizer
  第34回日本糖質学会年会
- Place of Presentation
  東京
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] 分子間距離情報に基づくアンフォテリシンB－エルゴステロール相互作用様式の解析2015
- Author(s)
  梅川雄一、中川泰男、松下直広、土川博史、花島慎弥、大石徹、松森信明、村田道雄
- Organizer
  第57回天然有機化合物討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-09-09
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Role of the polyol moiety of amphotericin B in permeabilizing membrane.2015
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Nobuaki Matsumori, Shinya Hanashima, Michio Murata, Resul Haser, Bernard J. Rawlings, Patrick Caffrey
- Organizer
  16th Tetrahedron Symposium Asia Edition
- Place of Presentation
  上海
- Year and Date
  2015-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Design and Synthesis of Heavy Atom Labelled GalCers for X-ray Co-crystalization with CD1d.2015
- Author(s)
  Md. Imran Hossain, Shinya Hanashima, Hiroshi Tsuchikawa, Michio Murata
- Organizer
  16th Tetrahedron Symposium Asia Edition
- Place of Presentation
  上海
- Year and Date
  2015-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 固体2H-NMRを用いたラクトシルセラミドとコレステロールの生体膜モデル中での相互作用解析2015
- Author(s)
  池田竜二、花島慎弥、土川博史、村田道雄
- Organizer
  第4回CSJ化学フェスタ
- Place of Presentation
  東京
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K01801
[Presentation] The effect of bisecting GlcNAc is indirect on binding to PHA-E lectin: A possible role for conformer selection2014
- Author(s)
  Masamichi Nagae, Keisuke Soga, Kana Morita-Matsumoto, Shinya Hanashima, Akemi Ikeda, Kazuo Yamamoto and Yoshiki Yamaguchi
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology 3rd Annual Symposium
- Place of Presentation
  Max Planck (Kreuth, Germany)
- Year and Date
  2014-05-22
- Invited
- Data Source
  KAKENHI-PROJECT-25460054
[Presentation] 新規重水素化アンフォテリシンB誘導体の合成と固体NMRによる配向解析2014
- Author(s)
  山本智也・梅川雄一・土川博史・花島慎弥・松森信明・村田道雄
- Organizer
  日本化学会第９４春季年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] NMRを用いた短鎖β1,3-glucanの構造と Dectin-1との相互作用解析2013
- Author(s)
  花島慎弥
- Organizer
  日本糖質学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24710257
[Presentation] NMR study of short β1,3-glucan structure and insight into the interaction with Dectin-12013
- Author(s)
  Shinya Hanashima, Akemi Ikeda, Yoshiki Yamaguchi
- Organizer
  The 5th ACGG conference
- Place of Presentation
  Khon Kaen, Thailand
- Data Source
  KAKENHI-PROJECT-24710257
[Presentation] Binding Analysis of Human Siglec-2 and Synthetic AG2 Pentasaccharide Using NMR2010
- Author(s)
  花島慎弥
- Organizer
  Technique理研ケミカルバイオロジー国際シンポジウム
- Place of Presentation
  理化学研究所
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] Binding Analysis of Human Siglec-2 and Synthetic AG2 Pentasaccharide Using NMR Technique2010
- Author(s)
  花島慎弥
- Organizer
  理研ケミカルバイオロジー国際シンポジウム
- Place of Presentation
  埼玉県和光市
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation]2009
- Author(s)
  花島慎弥
- Organizer
  三環性シアル酸供与体を用いた効率的シアリル化の検討日本糖質学会年会
- Place of Presentation
  高山
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] 三環性シアル酸供与体を用いた効率的シアリル化の検討2009
- Author(s)
  花島慎弥
- Organizer
  日本糖質学会年会
- Place of Presentation
  岐阜、高山
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] ガングリオシド糖鎖の化学合成とNMRを用いた相互作用解析2009
- Author(s)
  花島慎弥
- Organizer
  第6回糖鎖科学コンソーシアムシンポジウム
- Place of Presentation
  大阪、千里
- Year and Date
  2009-12-08
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] Synthesis of the unique starfish ganglioside AG2 pentasaccharide using silylene/oxazolidinone double-locked building blocks2009
- Author(s)
  花島慎弥
- Organizer
  20th Joint Glycobiology Meeting
- Place of Presentation
  Cologne, Germany
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] Synthesis and biological function of the unique starfish ganglioside AG2 pentasaccharide2009
- Author(s)
  花島慎弥
- Organizer
  Austria/Japan seminar on Comparative Glycobiology and Development Biology
- Place of Presentation
  神奈川、葉山
- Year and Date
  2009-09-21
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] Synthesis of the unique starfish ganglioside AG2 pentasaccharide using silylene/oxazolidinone double-locked building blocks2009
- Author(s)
  Shinya Hanashima
- Organizer
  Japanese-Giessen-GlycoWorkshop
- Place of Presentation
  Giessen, Germany
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation]2009
- Author(s)
  Shinya Hanashima
- Organizer
  Synthesis of the unique starfish ganglioside AG2 pentasaccharide using silylene/oxazolidinone double-locked building blocks 20th Joint Glycobiology Meeting
- Place of Presentation
  Cologne, Germany
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] Synthesis and biological function of the unique starfish ganglioside AG2 pentasaccharide Austria/Japan seminar on Comparative Glycobiology and Development Biology2009
- Author(s)
  Shinya Hanashima
- Place of Presentation
  葉山
- Year and Date
  2009-09-21
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] 新規シアル酸供与体を用いたガングリオシドAG2糖鎖の合成2008
- Author(s)
  花島慎弥
- Organizer
  有機合成化学協会関東支部会新潟シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2008-11-30
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] シアル酸を糖鎖中央部にもつガングリオシドAG-2五糖の合成研究2008
- Author(s)
  花島慎弥
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  筑波
- Year and Date
  2008-08-19
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] シアル酸を糖鎖中央部にもつガングリオシドAG-2五糖の合成研究2008
- Author(s)
  花島慎弥
- Organizer
  第28回日本糖質学会年会
- Place of Presentation
  筑波国際会議場
- Year and Date
  2008-08-19
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] 新規シアル酸供与体を用いたガングリオシドAG2糖鎖の合成2008
- Author(s)
  花島慎弥
- Organizer
  有機合成化学協会関東支部会新潟シンポジウム
- Place of Presentation
  新潟大学
- Year and Date
  2008-11-30
- Data Source
  KAKENHI-PROJECT-20710171
[Presentation] New synthetic route for labelled Amphotericin B derivative via beta glycosidation
- Author(s)
  Tomoya Yamamoto, Yuichi Umegawa, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata
- Organizer
  The 3rd International Symposium on Chemical Biology of Natural Products, Target ID and Regulation of Bioactivity
- Place of Presentation
  大阪
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] NMR interaction analysis of intestinal soluble lectin ZG16p with mycobacterium phosphatidylinositol mannosides
- Author(s)
  Shinya Hanashima, Mayumi Kanagawa, Sebastian Götze, Yan Liu, Akemi Ikeda, Daniel Varón Silva, Ten Feizi, Peter Seeberger, Yoshiki Yamaguchi
- Organizer
  SFG2014 annual meeting
- Place of Presentation
  ハワイ
- Year and Date
  2014-11-16 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24710257
[Presentation] Defining the interaction of human soluble lectin ZG16p and bacterial phosphatidylinositol mannosides
- Author(s)
  S. Hanashima, S. Götze, Y. Liu, M. Kato, A. Ikeda, K. Kojima-Aikawa, N. Taniguchi, D.V. Silva, T. Feizi, P. H. Seeberger and Y. Yamaguchi
- Organizer
  RIKEN-MAXPLANCK JOINT RESEARCH CENTER, 2nd Symposiuim
- Place of Presentation
  理化学研究所（埼玉県和光市）
- Data Source
  KAKENHI-PROJECT-25460054
[Presentation] 重水素標識スフィンゴ糖脂質の合成と固体NMR を用いたコレステロールとの分子間相互作用の解析
- Author(s)
  南角拓実, 池田竜二, 土川博史, 花島慎弥, 村田道雄
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  千葉
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] NMR analysis of Mycobacterium PIM glycans complexed with soluble lectin ZG16p
- Author(s)
  花島慎弥、Sebastian Götze、金川真由美、Yan Liu、池田明美、Ten Feizi、Peter Seeberger、谷口直之、山口芳樹
- Organizer
  第33回日本糖質学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-08-10 – 2014-08-12
- Data Source
  KAKENHI-PROJECT-24710257
[Presentation] スフィンゴミエリンアシル鎖の深度依存的融解現象の観測
- Author(s)
  門司真美, 土川博史, 花島慎弥, 松森信明, 村田道雄
- Organizer
  第4回CSJ化学フェスタ
- Place of Presentation
  東京
- Year and Date
  2014-10-14 – 2014-10-16
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] 重元素化脂質含有バイセルを用いた膜タンパク質結晶化法の検討
- Author(s)
  斎木悠, 花島慎弥, 村田道雄, 松森信明, 溝畑栄一, 井上豪, 川竹悟史, 垣之内啓介, 杉山成
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  千葉
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] バイセクト型糖鎖部分構造の合成と糖転移酵素阻害剤の分子設計戦略
- Author(s)
  花島慎弥
- Organizer
  第１２回糖鎖科学コンソーシアムシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-12-04 – 2014-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-24710257
[Presentation] ポリオール部分の相互作用解明を目指した新規アンフォテリシンB 誘導体の調製とイオンチャネル活性
- Author(s)
  山本智也, 梅川雄一, 土川博史, 花島慎弥, 村田道雄, 松森信明, Patrick Caffrey
- Organizer
  日本化学会第95春季年会
- Place of Presentation
  千葉
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-25242073
[Presentation] Temperature-dependent NOE analysis for the elucidation of glycan dynamics
- Author(s)
  J. Uzawa, S. Hanashima, H. Seki, and Y. Yamaguchi
- Organizer
  The 3rd Austria / Japan Seminar on Comparative and Developmental Glycobiology
- Place of Presentation
  理化学研究所（埼玉県和光市）
- Data Source
  KAKENHI-PROJECT-25460054

1. Murata Michio (40183652)

# of Collaborated Projects: 4 results

# of Collaborated Products: 78 results
2. 梅川雄一 (20587779)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
3. 土川博史 (30460992)

# of Collaborated Projects: 3 results

# of Collaborated Products: 38 results
4. 篠田渉 (70357193)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. Yamaguchi Yoshiki (90323451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. NAGAE Masamichi (60619873)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. SUGITA Yuji (80311190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松森信明 (50314357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
9. 松岡茂 (60456184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 李秀栄 (50390670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 三浦薫 (90353515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 櫻井香里 (50447512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 松尾一郎 (40342852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 石井希実 (60895275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 平林義雄 (90106435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 杉山成 (90615428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIZOHATA Eiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. HOSSAIN MD. IMRAN

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 朝比奈雄也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 渡邉望美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 菅恵嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 佐藤ちひろ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hanashima Shinya 花島 慎弥

HANASHIMA Shinya 花島 慎弥

花島 慎弥 ハナシマ シンヤ

Research Projects

Research Products

Co-Researchers

Novel method for synthesis of Phosphatidylglucoside: applied to cell surface glycosylation

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Average orientation of lipid acyl chains in the domain structure of model membranes

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植物特有のスフィンゴ脂質の構造と相互作用が誘起する脂質ラフトの描像の構築Principal Investigator

Principal Investigator

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Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions

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Elucidation of the formation mechanism on glycolipid-protein assemblages in lipid raftsPrincipal Investigator

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Dynamic conformation and domain structure of lipid molecules in model biomembranes

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Lipid interaction and headgroup conformation of glycosphingolipids in membrane bilayerPrincipal Investigator

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Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids

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Structural analysis of asymmetrically branched glycans

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Structure and interaction analysis of GPI-related glycansPrincipal Investigator

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Chemical synthesis of unique AG-gangliosides and evaluations of nerve cell stimulation activitiesPrincipal Investigator

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N-アセチルグルコサミン転移酵素V阻害剤を指向した二基質型アナログ化合物の合成Principal Investigator

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[Book] Glycoscience: Biology and Medicine Indirect detection of hydroxy proton exchange through deuterium-induced 13C-NMR isotope shifts2014

Author(s)

Hanashima Shinya 花島慎弥

HANASHIMA Shinya 花島慎弥

花島慎弥ハナシマシンヤ