Nakaya Tadashi 中矢正

… Alternative Names

中矢正ナカヤタダシ

NAKAYA Tadashi 中矢正

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Researcher Number	50374559
Other IDs
External Links
Affiliation (Current)	2025: 国際医療福祉大学, 福岡薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 国際医療福祉大学, 福岡薬学部, 講師 2022 – 2023: 国際医療福祉大学, 福岡薬学部, 講師 2020: 国際医療福祉大学, 福岡薬学部, 講師 2016 – 2019: 北海道大学, 薬学研究院, 助教 2015: 北海道大学, 薬学研究科(研究院), 助教 … More 2009: 北大, 薬学研究科(研究院), 助教 2008: Hokkaido University, 大学院・薬学研究院, 助教 2006: Hokkaido University, Faculty of Pharmaceutical Sciences, Instructor, 大学院薬学研究院, 助手 2005: 北海道大学, 大学院・農学研究科, 助手 2004 – 2005: 北海道大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator ALS / FUS / RNA結合 / R495X / FE65 / リン酸化 / APP / アルツハイマー病 / 分泌 / 細胞外 … More / 細胞外分泌 / RNA / 筋萎縮性側索硬化症 / 凝集体 / メチル化 / 大規模シーケンス / Ribo-seq / CLIP-seq / RNA-seq / 細胞死 / ストレス応答 / DNA損傷 / 核内移行 / 細胞内情報伝達機構 / AICD … More Except Principal Investigator APP / drug development / gene knockout mouse / neurodegenerative disease / p-amyloid / Alzheimer's disease / 神経変性疾患 / β-アミロイド / 神経 / セクリターゼ / ADAM / Alcadein / 代謝 / X11L / 神経変性 / 遺伝子破壊マウス / タンパク質相互作用 / βアミロイド / 認知症 / アルツハイマー病 Less

ALS原因因子FUSの細胞外分泌分子機構とその生理的意義の解明Principal Investigator
- Principal Investigator
  
  中矢正
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  International University of Health and Welfare
ALS原因因子FUSの細胞外分泌分子機構の解明Principal Investigator
- Principal Investigator
  
  中矢正
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  International University of Health and Welfare
Identification of a pathological mechanism induced by FUSR495X, an ALS linked FUS mutantPrincipal Investigator
- Principal Investigator
  
  Nakaya Tadashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  International University of Health and Welfare
  Hokkaido University
Identification of ALS linked FUS mutant induced pathological mechanism by genome-wide gene expression analysesPrincipal Investigator
- Principal Investigator
  
  NAKAYA Tadashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
FE65による細胞内情報伝達機構の解明Principal Investigator
- Principal Investigator
  
  中矢正
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
APP細胞内領域断片のリン酸化による細胞内情報伝達経路の制御機構解明Principal Investigator
- Principal Investigator
  
  中矢正
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Analysis of intracellular of APP metabolism and exploration of novel targets of drug suppressing Aβ generation
- Principal Investigator
  
  SUZUKI Toshiharu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University

All 2021 2020 2018 2017 2016 2015 2008 2007 2006 2005 2004

All Journal Article Presentation Book Patent

[Book] バイオとナノの融合II2007
- Author(s)
  中矢正
- Publisher
  北海道大学出版会(分担)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209002
[Book] APPの機能と代謝(医学のあゆみ)2007
- Author(s)
  中矢正, 鈴木利治(分担執筆)
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-17790046
[Journal Article] Cytoplasmic granule formation by FUS‐R495X is attributable to arginine methylation in all Gly‐rich, RGG1 and RGG2 domains2021
- Author(s)
  Kawahara Daiki、Suzuki Toshiharu、Nakaya Tadashi
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 3 Pages: 190-197
- DOI
  10.1111/gtc.12827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07361
[Journal Article] Dissection of FUS domains involved in regulation of SnRNP70 gene expression2020
- Author(s)
  Nakaya Tadashi
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 21 Pages: 3518-3529
- DOI
  10.1002/1873-3468.13924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07361
[Journal Article] Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity.2018
- Author(s)
  Nakaya T, Maragkakis M.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 15575-15575
- DOI
  10.1038/s41598-018-33964-0
- NAID
  120006540067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07361
[Journal Article] Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions2008
- Author(s)
  Toshiharu Suzuki & Tadashi Nakaya
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 29633-29637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790049
[Journal Article] Regulation of FE65 nuclear translocation and function by amylola beta-protein precursor in osmotically stressed cells2008
- Author(s)
  Tadashi Nakaya(他2名)
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 19119-19131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790049
[Journal Article] APPの機能と代謝2007
- Author(s)
  中矢正
- Journal Title
  
  医学のあゆみ 220・5
  
  Pages: 349-353
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] Trafficking of Alzheimer's Disease-Related Membrane Proteins and Its Participation in Disease Pathogenesis.2006
- Author(s)
  Suzuki T, Araki Y, Yamamoto T, Nakaya T
- Journal Title
  
  Journal of Biochemistry 139
  
  Pages: 949-955
- NAID
  10018844146
- Data Source
  KAKENHI-PROJECT-17790046
[Journal Article] Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.2006
- Author(s)
  Nakaya, T.
- Journal Title
  
  Genes to Cells 11
  
  Pages: 633-645
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.2006
- Author(s)
  Nakaya, T.
- Journal Title
  
  Genes Cells 11
  
  Pages: 633-645
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.2006
- Author(s)
  Nakaya, T., Suzuki, T.
- Journal Title
  
  Genes to Cells 11
  
  Pages: 633-645
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] Enhanced amyloidogenic metabolism of APPin X11L-deficient mouse brain.2006
- Author(s)
  Sano, Y., Takabatake-Syuzo, A., Nakaya, T., Tomita, S., Itohara, S., Suzuki, T.
- Journal Title
  
  Journal of Biological Chemistry 281
  
  Pages: 37853-878560
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] Physiological mouse brain Aβlevels are notrelated to the phosphorylation state of threonine-668 of Alzheimer's APP.2006
- Author(s)
  Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathew PM, Itohara S, Gandy S, Suzuki T
- Journal Title
  
  PLoS ONE 1
- Data Source
  KAKENHI-PROJECT-17790046
[Journal Article] Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD2006
- Author(s)
  Tadashi Nakaya, Toshiharu Suzuki
- Journal Title
  
  Genes to cells In press
- Data Source
  KAKENHI-PROJECT-17790046
[Journal Article] Physiological mouse brain Aβlevels are not related to the phosphorylation atate of threonine-668 of Alzheimer's APP.2006
- Author(s)
  Sano, Y., Nakaya, T., Pedrini, S., Takeda, S., Iijima-Ando, K., Iijima, K., Mathews, P.M., Itohara, S., Gandy, S., Suzuki, T.
- Journal Title
  
  Public Library of Science ONE 1
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] Metabolism of the Amyloid beta-Protein Precursor in the X11L-deficient Mouse Brain.2006
- Author(s)
  Sano Y, Syuzo-Takabatake A, Nakaya T, Saito Y, Tomita S, Itohara S, Suzuki T
- Journal Title
  
  Journal of Biological Chemistry 281
  
  Pages: 37853-37860
- Data Source
  KAKENHI-PROJECT-17790046
[Journal Article] Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.2006
- Author(s)
  Nakaya T, Suzuki T
- Journal Title
  
  Genes to Cells 11
  
  Pages: 633-645
- Data Source
  KAKENHI-PROJECT-17790046
[Journal Article] Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis.(Review)2006
- Author(s)
  Suzuki, T., Araki, Y., Yamamoto, T., Nakaya, T.
- Journal Title
  
  Journal of Biochemistry 139
  
  Pages: 949-955
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] Interaction of N-terminal acetyltransferase with the cytoplasmic domain of β-amyloid protein and its effect on Aβ secretion.2005
- Author(s)
  Asaumi, M., Iijima, K., Sumioka, A., Iijima, A.K., Kirino, Y., Nakaya, T., Suzuki, T.
- Journal Title
  
  Journal of Biochemistry 137
  
  Pages: 147-155
- Data Source
  KAKENHI-PROJECT-16209002
[Journal Article] RIPによる細胞内情報伝達と遺伝子発現制御2004
- Author(s)
  中矢正
- Journal Title
  
  実験医学 22・10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209002
[Patent] X11Lのリン酸化によるAPP結合制御の方式およびβ・アミロイド産生抑制法2005
- Inventor(s)
  鈴木利治, 多留偉功, 佐久間めぐみ, 田中絵美, 中矢正
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2005-139114
- Filing Date
  2005-05-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209002
[Presentation] FUS regulates the expression of snRNP70 by binding to its conserved intron in neuron2017
- Author(s)
  中矢　正
- Organizer
  北米神経科学会SfN2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07918
[Presentation] The relationship between cytotoxicity and function of FUS in neurons2016
- Author(s)
  中矢　正
- Organizer
  2015年度日本生化学会北海道支部・日本生物物理学会北海道支部合同シンポジウム
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2016-03-14
- Data Source
  KAKENHI-PROJECT-15K07918
[Presentation] In vivo における ALS 原因因子 FUS の標的 RNA の同定2015
- Author(s)
  3.中矢　正、Panagiotis Alexiou, Manolis Maragkakis, Alexandra Chang, Zissimos Mourelatos
- Organizer
  第17回日本RNA学会年会
- Place of Presentation
  ホテルライフォート札幌（北海道札幌市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15K07918
[Presentation] Identification of domains of FUS required for the regulation of genes with conserved introns.2015
- Author(s)
  中矢　正
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ（埼玉県さいたま市）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K07918
[Presentation] Nuclear translocation of FE65 regulated by AFT in osmotically stressed cells2008
- Author(s)
  Tadashi Nakaya(他2名)
- Organizer
  International Conference on Alzheimer's Disease 2008
- Place of Presentation
  McCormick Place(米国)
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-20790049

1. SUZUKI Toshiharu (80179233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

Nakaya Tadashi 中矢 正

中矢 正 ナカヤ タダシ

NAKAYA Tadashi 中矢 正

Research Projects

Research Products

Co-Researchers

ALS原因因子FUSの細胞外分泌分子機構とその生理的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ALS原因因子FUSの細胞外分泌分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of a pathological mechanism induced by FUSR495X, an ALS linked FUS mutantPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of ALS linked FUS mutant induced pathological mechanism by genome-wide gene expression analysesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

FE65による細胞内情報伝達機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

APP細胞内領域断片のリン酸化による細胞内情報伝達経路の制御機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of intracellular of APP metabolism and exploration of novel targets of drug suppressing Aβ generation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] バイオとナノの融合II2007

Author(s)

Publisher

Description

Data Source

[Book] APPの機能と代謝(医学のあゆみ)2007

Author(s)

Publisher

Data Source

[Journal Article] Cytoplasmic granule formation by FUS‐R495X is attributable to arginine methylation in all Gly‐rich, RGG1 and RGG2 domains2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dissection of FUS domains involved in regulation of SnRNP70 gene expression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions2008

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of FE65 nuclear translocation and function by amylola beta-protein precursor in osmotically stressed cells2008

Author(s)

Journal Title

Nakaya Tadashi 中矢正

中矢正ナカヤタダシ

NAKAYA Tadashi 中矢正