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Ito Kaoru  伊藤 薫

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伊藤 薫  イトウ カオル

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Researcher Number 50375664
Other IDs
Affiliation (Current) 2025: 千葉大学, 大学院医学研究院, 教授
2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help 2020 – 2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー
2018: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー
2016 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー
Review Section/Research Field
Principal Investigator
Basic Section 53020:Cardiology-related
Except Principal Investigator
Biological Sciences / Basic Section 53020:Cardiology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medical genome science
Keywords
Principal Investigator
遺伝リスクスコア / 人工知能 / 遺伝統計学 / 高速シークエンサー / ゲノミクス / 精密医療 / 浸透率 / レアバリアント / ゲノムリスクスコア / コモンバリアント / 遺伝子変異 / 心筋症 / 心不全 … More
Except Principal Investigator
… More 創薬 / コンソーシアム研究 / デジタル情報 / ゲノム・オミックス解析 / 循環器疾患 / 国際連携 / ゲノム解析 / 慢性血栓塞栓性肺高血圧症 / 機序解明 / マルチオミックス解析 / 心不全 / 心房細動 / 慢性心不全 / 治療抵抗性乳がん / ペリオスチン / 選択的スプライシングバリアント / 感受性分子 / ELISA系 / LDLR / FURIN / 結合抑制低分子 / NFKBIB / BRAP / 結合阻害低分子化合物 / 分子機能 / 虚血性心疾患感受性分子群 / 低分子化合物 / 虚血性心疾患感受性分子 / 動脈硬化 / 虚血性心疾患 Less
  • Research Projects

    (6 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (18 People)
  •  International Cardiovascular Digital Omics Consortium

    • Principal Investigator
      小室 一成
    • Project Period (FY)
      2024 – 2030
    • Research Category
      Fund for the Promotion of Joint International Research (International Leading Research )
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Integrative understanding of cardiac system architecture and its regulation

    • Principal Investigator
      野村 征太郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      The University of Tokyo
  •  Novel diagnostic and prognostic factors in chronic thromboembolic pulmonary hypertension based on genomic information.

    • Principal Investigator
      皆月 隼
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      The University of Tokyo
  •  Elucidation of genetic factors that define myocardial vulnerability as a basis for the development of heart failurePrincipal Investigator

    • Principal Investigator
      Ito Kaoru
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development of new therapeutics and diagnostics for breast cancer targeting specific alternative splicing variants

    • Principal Investigator
      Sanada Fumihiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Osaka University
  •  The innovative drug development that targeted molecules associated with coronary artery diseases and its functional analysis

    • Principal Investigator
      OZAKI Kouichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical genome science
    • Research Institution
      National Center for Geriatrics and Gerontology

All 2023 2022 2021 2018 2017

All Journal Article Presentation Book Patent

  • [Book] 循環器内科 第91巻第3号 循環器疾患のゲノム解析におけるバイオインフォマティクスの実際2022

    • Author(s)
      宮澤 一雄、伊藤 薫
    • Total Pages
      7
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Book] 心臓 Vol.54 Heart's selection 1 これから5年間の臨床・基礎研究の強化に向けて「循環器疾患におけるゲノム・オミクス研究の過去・現在・未来の展望」2022

    • Author(s)
      円山信之、伊藤 薫
    • Total Pages
      8
    • Publisher
      日本心臓財団
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Book] 第5土曜特集 循環器病学の未来 基本計画から考える循環器病学のグランドデザイン2022

    • Author(s)
      伊藤 薫
    • Total Pages
      7
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Book] 心臓 53巻 8号 P.793-7972021

    • Author(s)
      伊藤 薫
    • Total Pages
      5
    • Publisher
      公益財団法人日本心臓財団・一般社団法人日本循環器学会
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Book] 日本臨牀「特集:心不全の診療update -最新の診断と治療ー」79巻 8号 P.1153-11602021

    • Author(s)
      宮澤 一雄, 伊藤 薫
    • Total Pages
      8
    • Publisher
      日本臨牀社
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Journal Article] Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction2023

    • Author(s)
      Miyazawa Kazuo、Ito Kaoru、Ito Masamichi、Zou Zhaonan、Kubota Masayuki、Nomura Seitaro、Matsunaga Hiroshi、Koyama Satoshi、Ieki Hirotaka、et al.
    • Journal Title

      Nature Genetics

      Volume: 55 Issue: 2 Pages: 187-197

    • DOI

      10.1038/s41588-022-01284-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16128, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-21H02919, KAKENHI-PROJECT-20J01343, KAKENHI-PROJECT-22KJ1890, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-21K08023, KAKENHI-PROJECT-22H00471, KAKENHI-PROJECT-22KJ3142, KAKENHI-PROJECT-20H03525, KAKENHI-PROJECT-23K24602
  • [Journal Article] TEAD1 trapping by the Q353R?Lamin A/C causes dilated cardiomyopathy2023

    • Author(s)
      Yamada S、et al.,
    • Journal Title

      Science Advances

      Volume: 9 Issue: 15 Pages: 1-1

    • DOI

      10.1126/sciadv.ade7047

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06809, KAKENHI-PROJECT-21K16082, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-21K16047, KAKENHI-PROJECT-22H00471, KAKENHI-PLANNED-19H05744, KAKENHI-PLANNED-21H05254, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-23K24057
  • [Journal Article] LMNA Mutations and Right Heart Failure in Patients With Cardiomyopathy and With Left Ventricular Assist Devices2023

    • Author(s)
      Yamada T, Nomura S, Amiya E, Katoh M, Inoue S, Hatsuse S, Fujita K, Ito M, Fujita T, Bujo C, Tsuji M, Ishida J, Ko T, Yamada S, Katagiri M, Sassa T, Kinoshita O, Nawata K, Tobita T, Satoh M, Ishiwata J, Daimon M, Tatsuno K, Fukuda S, Kashimura T, Minamino T, Hatano M, Ono M, Aburatani H, Komuro I.
    • Journal Title

      Journal of Cardiac Failure

      Volume: 29 Issue: 5 Pages: 855-857

    • DOI

      10.1016/j.cardfail.2023.01.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-21K16047, KAKENHI-PROJECT-21K08047, KAKENHI-PROJECT-22H00471
  • [Journal Article] Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis2022

    • Author(s)
      Ko Toshiyuki、Nomura Seitaro、Yamada Shintaro、Fujita Kanna、Fujita Takanori、Satoh Masahiro、Oka Chio、Katoh Manami、Ito Masamichi、Amiya Eisuke、Hatano Masaru、Kinoshita Osamu、Nawata Kan、Abe Hiroyuki、Ushiku Tetsuo、Ono Minoru、Ikeuchi Masashi、Morita Hiroyuki、Aburatani Hiroyuki、Komuro Issei
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 3275-3275

    • DOI

      10.1038/s41467-022-30630-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16047, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-22H00471
  • [Journal Article] Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling2022

    • Author(s)
      Adachi Yusuke、Ueda Kazutaka、Nomura Seitaro、Ito Kaoru、Katoh Manami、Katagiri Mikako、Yamada Shintaro、Hashimoto Masaki、Zhai Bowen、Numata Genri、Otani Akira、Hinata Munetoshi、Hiraike Yuta、Waki Hironori、Takeda Norifumi、Morita Hiroyuki、Ushiku Tetsuo、Yamauchi Toshimasa、Takimoto Eiki、Komuro Issei
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 5117-5117

    • DOI

      10.1038/s41467-022-32658-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K16097, KAKENHI-PROJECT-22K16130, KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-19K17976, KAKENHI-PROJECT-19H03649, KAKENHI-PROJECT-22H00471, KAKENHI-PROJECT-21H02908
  • [Journal Article] Prediction Score-Guided Genetic Testing for Hypertrophic Cardiomyopathy2021

    • Author(s)
      Ito Kaoru、Morita Hiroyuki
    • Journal Title

      Circ J

      Volume: 85 Issue: 5 Pages: 675-676

    • DOI

      10.1253/circj.CJ-20-1287

    • NAID

      130008028994

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-04-23
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Journal Article] Contribution of Noncanonical Splice Variants to TTN Truncating Variant Cardiomyopathy2021

    • Author(s)
      Patel Parth N.、Ito Kaoru、Willcox Jon A.L.、Haghighi Alireza、Jang Min Young、Gorham Joshua M.、DePalma Steven R.、Lam Lien、McDonough Barbara、Johnson Renee、Lakdawala Neal K.、Roberts Amy、Barton Paul J.R.、Cook Stuart A.、Fatkin Diane、Seidman Christine E.、Seidman J.G.
    • Journal Title

      Circulation: Genomic and Precision Medicine

      Volume: 14 Issue: 5

    • DOI

      10.1161/circgen.121.003389

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Journal Article] The Evolving Story in the Genetic Analysis for Heart Failure2021

    • Author(s)
      Miyazawa Kazuo、Ito Kaoru
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 8 Pages: 646816-646816

    • DOI

      10.3389/fcvm.2021.646816

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Journal Article] Genome-wide analysis identifies novel susceptibility loci for myocardial infarction2021

    • Author(s)
      Hartiala Jaana A、Ito Kaoru、Allayee Hooman
    • Journal Title

      European Heart Journal

      Volume: 42 Issue: 9 Pages: 919-933

    • DOI

      10.1093/eurheartj/ehaa1040

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Journal Article] IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment with split read analysis2018

    • Author(s)
      Shigemizu Daichi、Miya Fuyuki、Akiyama Shintaro、Okuda Shujiro、Boroevich Keith A、Fujimoto Akihiro、Nakagawa Hidewaki、Ozaki Kouichi、Niida Shumpei、Kanemura Yonehiro、Okamoto Nobuhiko、Saitoh Shinji、Kato Mitsuhiro、Yamasaki Mami、Matsunaga Tatsuo、Mutai Hideki、Kosaki Kenjiro、Tsunoda Tatsuhiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5608-5608

    • DOI

      10.1038/s41598-018-23978-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15530, KAKENHI-PROJECT-16K19068, KAKENHI-PROJECT-18K09336, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-16H04726, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-16K07211, KAKENHI-PROJECT-16H06299
  • [Journal Article] Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure.2018

    • Author(s)
      Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 4435-4435

    • DOI

      10.1038/s41467-018-06639-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-16H04726, KAKENHI-PROJECT-17H04061, KAKENHI-PROJECT-17H06566, KAKENHI-PROJECT-18K08097
  • [Journal Article] Blood lipid-related low-frequency variants in LDLR and PCSK9 are associated with onset age and risk of myocardial infarction in Japanese.2018

    • Author(s)
      2)Tajima T, Morita H, Ito K, Yamazaki T, Kubo M, Komuro I, Momozawa Y.
    • Journal Title

      Scientific Reports

      Volume: 8 (1) Issue: 1 Pages: 8107-8107

    • DOI

      10.1038/s41598-018-26453-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04726, KAKENHI-PROJECT-17H04061
  • [Journal Article] Identification of six novel genetic loci associated with atrial fibrillation in Japanese population.2017

    • Author(s)
      Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT, AFGen Consortium, Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M, Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka T.
    • Journal Title

      Nature Genetics

      Volume: - Issue: 6 Pages: 953-958

    • DOI

      10.1038/ng.3842

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04726, KAKENHI-PROJECT-15K08539, KAKENHI-PROJECT-16K00385, KAKENHI-PROJECT-26293052, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K07251
  • [Patent] 不整脈または不整脈関連障害のリスク判定方法及びリスク判定システム2022

    • Inventor(s)
      伊藤 薫、宮澤 一雄
    • Industrial Property Rights Holder
      伊藤 薫、宮澤 一雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-130225
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] Cardiovascular Genomics for Disease Biology and Comorbidity Prediction2023

    • Author(s)
      Kaoru Ito
    • Organizer
      The 6th RIKEN IMS-Stanford ISCBRM Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] Applying GWAS and Omics in Cardiovascular Diseases2023

    • Author(s)
      Kaoru Ito
    • Organizer
      The 1st International Conference of Cardiovascular, Metabolic, and Aging Research Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] Genetic Analysis of All-cause Heart Failure Using Deep Sequencing2023

    • Author(s)
      吉田 浩紀、伊藤 薫
    • Organizer
      第87回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] 多因子循環器疾患のゲノム解析と臨床応用の最前線2022

    • Author(s)
      伊藤 薫
    • Organizer
      第4回NCVC Seminar Series
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] 大規模NGSデータを基盤としたゲノム解析「大規模バイオバンクを用いたヒト循環器疾患ゲノム解析の最前線」2022

    • Author(s)
      伊藤 薫
    • Organizer
      2022年日本バイオインフォマティクス学会年会 第11回生命医薬情報学連合大会
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] How Should We Apply Omics on Cardiovascular Diseases to Clinical Medicine?2021

    • Author(s)
      伊藤 薫
    • Organizer
      CVCT(Cardiovascular Clinical Trialist)- Asia-Pacific Forum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] Basic Science Summit Session3: The Promise and Peral of Next-Generation sequencing "AIを用いたメンデル遺伝病Variant of Unknown Significanceの解釈”2021

    • Author(s)
      伊藤 薫
    • Organizer
      第67回日本不整脈心電図学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] シンポジウム1 生活習慣病のゲノム研究の最前線「心疾患のゲノム解析の最前線」2021

    • Author(s)
      伊藤 薫
    • Organizer
      日本人類遺伝学会第66回大会・第28回日本遺伝子診療学会大会合同開催
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] シンポジウム3 心不全ゲノム医療の最前線「ゲノムから見た「一般的な」疾患としての心不全研究」2021

    • Author(s)
      伊藤 薫
    • Organizer
      第25回日本心不全学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H02919
  • [Presentation] Trans-Ethnic Meta-Analysis of Genome-Wide Association Studies for Coronary Artery Disease Highlights the Importance of Immune System2018

    • Author(s)
      Matsunaga H, Ito K, Akiyama M, Koyama S, Onouchi Y, Ozaki K, Morita H, Akazawa H, Kamatani Y, Ko,uro I.
    • Organizer
      American Heart Association SCIENTIFIC SESSION 2018 (USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04726
  • [Presentation] Trans-ethnic meta-analysis of genome-wide association studies for coronary artery disease reveals genetic differences between Japanese and Europeans2018

    • Author(s)
      Matsunaga H, Koyama K, Onouchi Y, Ozaki K, Morita H, Akazawa H, Komuro I, Akiyama M, Kubo M, Kamatani Y, Ito K.
    • Organizer
      ASHG 2018 Annual Meeting (USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04726
  • 1.  OZAKI Kouichi (50373288)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  野村 征太郎 (10722118)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  Sanada Fumihiro (30722227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  黒柳 秀人 (30323702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  桃沢 幸秀 (40708583)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  山口 尊則 (70834810)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  野出 孝一 (80359950)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  皆月 隼 (50772761)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  小室 一成 (30260483)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  中戸 隆一郎 (60583044)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  小寺 聡 (80794776)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  松久 直司 (90879876)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YOSHII Mayumi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  家城 博隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  油谷 浩幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  斉藤 伸治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  安達 裕助
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  東口 治弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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※ この処理は、研究者本人だけが実行できます。

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