MOCHIZUKI Tsutomu 望月勉

Researcher Number	50377496
Affiliation (based on the past Project Information) *help	2014 – 2016: 山梨大学, 総合研究部, 医学研究員 2011 – 2013: 山梨大学, 医学工学総合研究部, 医学研究員 2011: 山梨大学, 医学部付属病院, 助教 2009 – 2011: 山梨大学, 大学院・医学工学総合研究部, 医学研究員 2008: 山梨大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Urology Except Principal Investigator Urology
Keywords	Principal Investigator 膀胱上皮 / ＤＲＧ / 膀胱平滑筋 / DRG / 膀胱排尿筋 / 求心性伝達 / 排尿生理 / 尿意 / 過活動膀胱 / 蓄尿障害 … More / 求心性シグナル伝達 / TRPV4 / Piezo1 / ＴＲＰＶ４ / メカノセンサー / ATP / TRPV４ … More Except Principal Investigator イオンチャネル / 膀胱 / 尿路上皮 / ATP / メカノセンサー / TRP / Piezo1 / P2Y6 / PIEZO / VNUT / Overactive bladder / Urinary bladder / Afferent nerve / 間質性膀胱炎 / 上皮 / 酸 / 膀胱炎 / イオンチャンネル / 排尿 / 炎症 / 痛み / 知覚 / 膀胱上皮 / 膀胱平滑筋 / 小胞体ストレス / 膀胱機能障害 / 求心性伝達機構 / 過活動膀胱 / TRPV4 / TRP TRPV4 / 細胞内カルシウムイオン / 膀胱上皮細胞 Less

Elucidation of intercellular signaling mechanism from urinary bladder epithelium to detrusor / DRG in stretching stimulationPrincipal Investigator
- Principal Investigator
  
  MOCHIZUKI Tsutomu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Yamanashi
Research on the afferent transduction in the lower urinary tract
- Principal Investigator
  
  TAKEDA Masayuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  University of Yamanashi
Involvements of TRPV1 and TRPV4 channels in regulatory function to maintain bladder stability during urine storage: integrated analysis of behavior and reflexPrincipal Investigator
- Principal Investigator
  
  MOCHIZUKI Tsutomu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Yamanashi
閉塞膀胱における膀胱の機能不全と小胞体ストレスとの関連についての研究
- Principal Investigator
  
  澤田智史
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  University of Yamanashi
Contribution of acid-sensing nociceptor molecules (ASIC and TRPV1) to symptom onset in interstitial cystitis
- Principal Investigator
  
  ARAKI Isao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Shiga University of Medical Science
  University of Yamanashi
Reseaarch on the function and development of new therapy for Ion channels in the lower urinary tract
- Principal Investigator
  
  TAKEDA Masayuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  University of Yamanashi

All 2015 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book

[Book] 排尿障害プラクティス2012
- Author(s)
  中込宙史、望月勉、武田正之
- Total Pages
  8
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23592361
[Journal Article] Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle.2015
- Author(s)
  Yoshiyama M, Mochizuki T, Nakagomi H, Miyamoto T, Kira S, Mizumachi R, Sokabe T, Takayama Y, Tominaga M, Takeda M.
- Journal Title
  
  Am J Physiol Renal Physiol.
  
  Volume: in-press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462437
[Journal Article] Functional role for Piezo1 in stretch-evoked Ca2+ influx and ATP release in urothelial cell cultures2014
- Author(s)
  Tatsuya Miyamoto, Tsutomu Mochizuki, Hiroshi Nakagomi, Satoru Kira, Masaki Watanabe, Yasunori Takayama, Yoshiro Suzuki, Schuichi Koizumi, Masayuki Takeda and MakotoTominaga
- Journal Title
  
  J Biol Chem
  
  Volume: (Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-23592361
[Journal Article] Functional role for Piezo1 in stretch-evoked Ca 2+ influx and ATP release in urothelial cell cultures2014
- Author(s)
  Tatsuya Miyamoto, Tsutomu Mochizuki, Hiroshi Nakagomi, Satoru Kira, Masaki Watanabe, Yasunori Takayama, Yoshiro Suzuki, Schuichi Koizumi, Masayuki Takeda and Makoto Tominaga
- Journal Title
  
  J Biol Chem
  
  Volume: 130 Issue: 23 Pages: 452-462
- DOI
  10.1074/jbc.m113.528638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592426, KAKENHI-PROJECT-24791640, KAKENHI-PROJECT-26462437
[Journal Article] Functional role for Piezo1 in stretch-evoked Ca 2+ influx and ATP release in urothelial cell cultures.2014
- Author(s)
  Miyamoto T, Mochizuki T, Nakagomi H, Kira S, Watanabe M, Takayama Y, Suzuki Y, Koizumi S, Takeda M, Tominaga M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 53 Pages: 1230-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592361
[Journal Article] 膀胱上皮におけるTRPVチャネルとATP放出メカニズム2013
- Author(s)
  中込宙史、望月勉、武田正之
- Journal Title
  
  膀胱上皮におけるTRPVチャネルとATP放出メカニズム
  
  Volume: vol.20 Pages: 7-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592361
[Journal Article] 膀胱上皮におけるTRPVチャネルとATP放出メカニズム2012
- Author(s)
  中込宙史、望月勉、武田正之
- Journal Title
  
  排尿障害プラクティス
  
  Volume: vol.20, No.1 Pages: 7-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592361
[Journal Article] VNUT(Vesicular Nucleotide Transporter)を介する膀胱上皮からのATP放出メカニズム2011
- Author(s)
  中込宙史、望月勉、芳山充晴、宮本達也吉良聡、川原和也、荒木勇雄、小泉修一森山芳則、武田正之
- Journal Title
  
  日本排尿機能学会誌
  
  Volume: Vol.22(1) Pages: 121-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592361
[Journal Article] Emerging families of ion channel involved in urinary bladder nociception.2010
- Author(s)
  Araki I, Yoshiyama M, Kobayashi H, Mochizuki M, Du S, Okada Y, Takeda M
- Journal Title
  
  Pharmaceuticals
  
  Volume: 3 Pages: 2248-2267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592068
[Journal Article] Sensor mechanism and afferent signal transduction of the urinary bladder: special focus on TRP ion channels2010
- Author(s)
  Takeda M, Mochizuki T, Yoshiyama M, Nakagomi H, Kobayashi H, Sawada N, Zakoji H, Du S, Araki I
- Journal Title
  
  LUTS: Lower Urinary Tract Symptoms
  
  Volume: 2(2) Issue: 2 Pages: 51-60
- DOI
  10.1111/j.1757-5672.2010.00074.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592068
[Journal Article] The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Pathophysiology of Voiding Dysfunction and Pharmacological Therapy2010
- Author(s)
  Takeda M, Araki I, Mochizuki T, Nakagomi H, Kobayashi H, Sawada N, Zakoji H
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 112 Issue: 2 Pages: 121-127
- DOI
  10.1254/jphs.09R17FM
- NAID
  10029888469
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592068
[Journal Article] Emerging families of ion channel involved in urinary bladder nociception2010
- Author(s)
  Araki I, Yoshiyama M, Kobayashi H, Mochizuki M, Du S, Okada Y, Takeda M
- Journal Title
  
  Pharmaceuticals
  
  Volume: 3(7) Issue: 7 Pages: 2248-2267
- DOI
  10.3390/ph3072248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592068
[Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca2+influx and ATP release in primary urothelial cell cultures2009
- Author(s)
  Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, Koizumi S, Takeda M, Tominaga M
- Journal Title
  
  J Biol Chem
  
  Volume: 284(32) Issue: 32 Pages: 21257-21264
- DOI
  10.1074/jbc.m109.020206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592068
[Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca^<2+> influx and ATP release in primary urothelial cell cultrues.2009
- Author(s)
  Mochizuki T
- Journal Title
  
  J Biol Chem 284
  
  Pages: 21257-21264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592068
[Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures.2009
- Author(s)
  Mochizuki T
- Journal Title
  
  J Biological Chemistry 284
  
  Pages: 21257-21264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390423
[Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca2^+ influx and ATP release in primary urothelial cell cultures.2009
- Author(s)
  Mochizuki T, Sokabe T. Araki I, Fujishita K, Shibasaki K, Uchida K, Naruse K, Koizumi S, Takeda M, Tominaga M
- Journal Title
  
  J.Biological Chemistry 284
  
  Pages: 21257-21264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390423
[Presentation] 排尿用代謝ケージを用いたマウス排尿における各種パラメータについて2011
- Author(s)
  望月勉
- Organizer
  日本排尿機能学会
- Place of Presentation
  ホテルフジタ福井（福井県福井市）
- Data Source
  KAKENHI-PROJECT-23592361
[Presentation] TRPV4-DEFICIENT MICE EXHIBIT INCREASED FREQUENCY OF VOIDING : ~EVALUATION OF MICTURITION BEHAVIOUR USING NOVEL METABOLIC CAGE SYSTEM~2011
- Author(s)
  Tsutomu Mochizuki
- Organizer
  International Continence Society
- Place of Presentation
  イギリス
- Data Source
  KAKENHI-PROJECT-23592361
[Presentation] 新規ディバイス排尿用代謝ケージを用いたマウス排尿における各種パラメーターについて～野生型マウスとTRPVノックアウトマウスとの比較～2011
- Author(s)
  望月勉
- Organizer
  第99回日本泌尿器科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592361
[Presentation] 腎平滑筋種の1例2011
- Author(s)
  望月勉
- Organizer
  第78回日本泌尿器科学会山梨地方会
- Place of Presentation
  山梨
- Data Source
  KAKENHI-PROJECT-23592361
[Presentation] TRPV4-KO mice exhibit increased voiding frequency2011
- Author(s)
  Tsutomu Mochizuki
- Organizer
  ICS41st Annual Meeting
- Place of Presentation
  Scotish Exhibition&conference Center（Glasgow, U.K）
- Data Source
  KAKENHI-PROJECT-23592361
[Presentation] 新規のマウス用排尿代謝ケージ構築ならびに各種パラメーターについて～野生型マウスとTRPV4ノックアウトマウスとの比較～2011
- Author(s)
  望月勉
- Organizer
  第18回日本排尿機能学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-23592361
[Presentation] The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures using original culture cell stretch system2010
- Author(s)
  Mochizuki T, Nakagomi H, Miyamoto T, Araki I, Yoshiyama M, Takeda M
- Organizer
  American Urological Association 105th annual meeting, San Francisco
- Place of Presentation
  CA, USA
- Data Source
  KAKENHI-PROJECT-21592068
[Presentation] The TRPV4 cation channel mediates stretchi-evoked CA2^+ influx and ATP release in primary urothelial cell cultures using original culture cell stretch system2010
- Author(s)
  Tsutomu Mochizuki, Hiroshi Nakagomi, Tatsuya Miyamoto, Isao Araki, Mitsuharu Yoshiyama, Masayuki Takeda
- Organizer
  AUA 2010
- Place of Presentation
  U.S.A.
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-20390423
[Presentation] Sex difference in expression profile of acid-sensing ion channels and transient receptor potential channel V1 in the mouse urinary bladder2009
- Author(s)
  Kobayashi H, Yoshiyama M, Araki I, Sawada N, Mochizuki T, Zakoji H, Takeda M
- Organizer
  International Continence Society 39th Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21592068
[Presentation] PDGF-mediated regulation of connexin43 expression in bladder smooth muscle cells2009
- Author(s)
  Norifumi SAWADA, Jian YAO, Nobuhiko HIRAMATSUE, Hideki Kobayashi, Hidenori Zakoji, Tsutomu Mochizuki, Masanori KITAMURA, Isao Araki, Masayuki Takeda
- Organizer
  The 4th Pan-Pacific Continence Society Meeting
- Place of Presentation
  Fukuoka
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20390423
[Presentation] The expression of transient receptor potential (TRP) V4, A1 and V1 in the human bladder mucosa of normal and bladder outlet obstruction: a novel mechanism in the obstruction-induced bladder overactivity2009
- Author(s)
  Miyamoto T, Mochizuki T, Zakoji H, Kobayashi H, Yoshiyama M, Araki I, Takeda M
- Organizer
  International Continence Society 39th Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21592068
[Presentation] Contribution of acid-sensing ion channels to gender difference in mouse bladder response to acetic acid : a novel candidate for interstitial cystitis pathogenesis.2008
- Author(s)
  Kobayashi H, Yoshiyama M, Araki I, Zakoji H, Sawada N, Mochizuki T, Tsuchuida T, Nomura T, Fukasawa M, Takeda M.
- Organizer
  The 103^<rd> Annual Meeting of The American Urological Association.
- Place of Presentation
  Orland, USA
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20390423
[Presentation] The expression of prostaglandin E2 receptors (EP1, 2, 3, and 4) in the human bladder epithelium of normal and bladder outlet obstruction. -a novel mechanism in the afferent hyperactivity of bladder.2008
- Author(s)
  Yuanjun J, Kobayashj H, Sawada N, Yoshiyama M, Mochizuki T, Zakoji H, Araki I, Takeda M.
- Organizer
  The 103^<rd> Annual Meeting of The American Urological Association.
- Place of Presentation
  Orland, USA
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20390423
[Presentation] The expression of prostaglandin E2 receptors (EP1, 2, 3, and 4) in the human urinary bladder epithelium of normal and bladder outlet obstruction.2008
- Author(s)
  Jiang Yuan Jun, Hideki Kobayashi, Norifumi SAWADA, Mitsuharu Yoshiyama, Tsutomu Mochizuki, Hidenori Zakoji, Isao Araki, Masayuki Takeda
- Organizer
  -A novel mechanism in the E10afferent hyperactivity of bladder-,AUA2008
- Place of Presentation
  U.S.A.
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20390423

1. TAKEDA Masayuki (80197318)

# of Collaborated Projects: 7 results

# of Collaborated Products: 21 results
2. KOBAYASHI Hideki (50402053)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
3. YOSHIYAMA Mitsuharu (20422694)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
4. ARAKI Isao (50252424)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
5. ZAKOUJI Hidenori (60345717)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. SAWADA Norifumi (70402055)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
7. TOMINAGA Makoto (90260041)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. NAKAGOMI Hiroshi (80418714)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. KIRA Satoru (10530115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. FUKASAWA Mizuya (80252039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. TSUCHIDA Takayuki (30217327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TSURU Teruhiko (90625675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KOIZUMI Syuichi (10280752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIYAMOTO Tatsuya (80456459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

MOCHIZUKI Tsutomu 望月 勉

Research Projects

Research Products

Co-Researchers

Elucidation of intercellular signaling mechanism from urinary bladder epithelium to detrusor / DRG in stretching stimulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on the afferent transduction in the lower urinary tract

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvements of TRPV1 and TRPV4 channels in regulatory function to maintain bladder stability during urine storage: integrated analysis of behavior and reflexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

閉塞膀胱における膀胱の機能不全と小胞体ストレスとの関連についての研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Contribution of acid-sensing nociceptor molecules (ASIC and TRPV1) to symptom onset in interstitial cystitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reseaarch on the function and development of new therapy for Ion channels in the lower urinary tract

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 排尿障害プラクティス2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle.2015

Author(s)

Journal Title

Data Source

[Journal Article] Functional role for Piezo1 in stretch-evoked Ca2+ influx and ATP release in urothelial cell cultures2014

Author(s)

Journal Title

Data Source

[Journal Article] Functional role for Piezo1 in stretch-evoked Ca 2+ influx and ATP release in urothelial cell cultures2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional role for Piezo1 in stretch-evoked Ca 2+ influx and ATP release in urothelial cell cultures.2014

Author(s)

Journal Title

Data Source

[Journal Article] 膀胱上皮におけるTRPVチャネルとATP放出メカニズム2013

Author(s)

Journal Title

Data Source

[Journal Article] 膀胱上皮におけるTRPVチャネルとATP放出メカニズム2012

Author(s)

Journal Title

Data Source

[Journal Article] VNUT(Vesicular Nucleotide Transporter)を介する膀胱上皮からのATP放出メカニズム2011

Author(s)

Journal Title

Data Source

[Journal Article] Emerging families of ion channel involved in urinary bladder nociception.2010

Author(s)

Journal Title

Data Source

[Journal Article] Sensor mechanism and afferent signal transduction of the urinary bladder: special focus on TRP ion channels2010

Author(s)

MOCHIZUKI Tsutomu 望月勉