NEGI Shigeru 根木滋

Researcher Number	50378866
Other IDs
External Links
Affiliation (Current)	2025: 同志社女子大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 同志社女子大学, 薬学部, 准教授 2008 – 2015: Doshisha Women's College of Liberal Arts, 薬学部, 助教 2014: 同志社女子大学, 薬学部, 特任助教 2011: 同志社女子大学, 薬学部, 助手 2005 – 2007: 同志社女子大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Living organism molecular science / Biomolecular chemistry Except Principal Investigator Drug development chemistry / Biomolecular chemistry / Physical pharmacy / Living organism molecular science / Chemistry related to living body
Keywords	Principal Investigator 転写因子 / 亜鉛フィンガー / レドックスセンサー / レドックス / DAN結合 / 金属結合 / 蛋白質 / GAGAファクター / 人工制限酵素 / Sp1亜鉛フィンガー … More / ペプチドデザイン / 金属フィンガー / レドックスレンサー / 酸化 / 過酸化水素 / レドックス反応 / 亜鉛フィンガータンパク質 / 無細胞系タンパク質発現 / ＤＮＡ結合 / レドックス挙動 / 分子進化実験 / 細胞移行 / 金属置換 / シグナル伝達 / DNA結合 / 金属イオン / 酸化還元 / 人工ヌクレアーゼ / 人工蛋白質 / DNA / タンパク質工学 / SELEX法 / Spl亜鉛フィンガー / 人工ペプチダーゼ / 核酸・薬学 / 生体分子 / 生体機能利用 / 人工ペプチド / 配位結合 / DNA認識 … More Except Principal Investigator 転写因子 / 亜鉛フィンガー / DNA認識 / 人工設計 / 超分子錯体 / GAGA因子 / 遺伝子制御 / マルチフィンガー / タンパク質デザイン / ガスバイオロジー / サーガディアンリズム / シクロデキストリン / 時計遺伝子 / 炎症 / ヘム / 概日リズム / 体内時計 / 一酸化炭素 / Gene Regulation / GAGA Factor / Library / Multifinger / Protein Design / DNA Recognition / Zinc Finger / Metallofinger / GAGAファクター / タンパク質設計 / ライブラリー / 金属フィンガー / 蛋白質 / バイオテクノロジー / 遺伝子 / 分子認識 / 亜鉛フィンガー蛋白質 / 生命錯体化学 / 制限酵素 / DNA切断 / 機能変換 / 加水分解 / 分子設計 / 酵素類似 / 触媒機能 / DNA 切断 / DNA 認識 / PEG化 / 酸素親和性 / 高分子化 / 人工酸素運搬体 / 自己触媒的酸化反応 / 金ナノ粒子 / 人工血液 / 酸素付加体 / 機能性高分子 / ポリアクリル酸 / 血清タンパク質 / 動物実験 / イミダゾール配位 / ヒドロキソコバラミン / 青酸中毒解毒作用 / 鉄ポルフィリン / シクロデキストリン二量体 / ヘムタンパク質 / ナノバイオ / 超分子化学 / マルチフインガー / Zif268 / 人工転写因子 / DNA結合 Less

Study on the role of endogenous CO in the circadian clock system
- Principal Investigator
  
  Hiroaki Kitagishi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Doshisha University
Investigation of new zinc finger protein function as a redox sensor for reactive oxygen in the cellsPrincipal Investigator
- Principal Investigator
  
  NEGI SHIGERU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Doshisha Women's College of Liberal Arts
Specific DNA Recognition by Fluctuation of Zinc Finger Protein and Development for Smart Transcription Factor
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Doshisha Women's College of Liberal Arts
Structural and functional analysis of zinc finger protein in metal binding and redox reactionPrincipal Investigator
- Principal Investigator
  
  NEGI SHIGERU
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Doshisha Women's College of Liberal Arts
Creation of First Enzyme-Type Zinc Finger Protein PossessingCatalytic Function
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Doshisha Women's College of Liberal Arts
Capture of diatomic molecules by supramolecular heme protein models and application to development to medicinal chemistry
- Principal Investigator
  
  KANO Koji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Doshisha University
Creation and Pharmaceutical Development of Intelligent Zinc Fingers Based on Genomic Chemistry
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Doshisha Women's College of Liberal Arts
Creation of artificial peptidase based on zinc finger frameworkPrincipal Investigator
- Principal Investigator
  
  NEGI Shigeru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Doshisha Women's College of Liberal Arts
触媒作用を有する人工金属フィンガータンパク質の創製Principal Investigator
- Principal Investigator
  
  根木滋
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Doshisha Women's College of Liberal Arts
Creation of New Functional Artificial Metallofingers : Construction of Library and Development to Gene Regulation
- Principal Investigator
  
  SUGIURA Yukio
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Doshisha Women's College of Liberal Arts

All 2019 2018 2015 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] "Non-FokI-based zinc finger nuclease" in Engineered Zinc Finger proteins2010
- Author(s)
  S.Negi
- Total Pages
  12
- Publisher
  Methods in Molecular Biology, Vol.649
- Data Source
  KAKENHI-PROJECT-20510206
[Book] Engineered Zinc Figer Proteins(Eds.by J.P.Mackey, D.J.Segal)(Non-FolkI-based zinc finger nucleases)2010
- Author(s)
  M.Imanishi, S.Negi, Y.Sugiura
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20390037
[Book] Non-FokI-based zinc finger nuclease(Engineered Zinc Finger proteins, <Eds. by J. Mackay and D. Segal>, Methods in Molecular Biology, Vol.649)
- Author(s)
  Shigeru Negi, et. al.
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per‐ O ‐Methylated β‐Cyclodextrin Cavity in Serum, Blood, and Urine2019
- Author(s)
  Kitagishi Hiroaki、Saito Mai、Mao Qiyue、Kiriyama Akiko、Negi Shigeru、Kano Koji
- Journal Title
  
  Chemistry An Asian Journal
  
  Volume: 14 Issue: 19 Pages: 3320-3328
- DOI
  10.1002/asia.201900983
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02208
[Journal Article] Circadian clock disruption by selective removal of endogenous carbon monoxide2018
- Author(s)
  Minegishi Saika、Sagami Ikuko、Negi Shigeru、Kano Koji、Kitagishi Hiroaki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 11996-11996
- DOI
  10.1038/s41598-018-30425-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02208, KAKENHI-PROJECT-16K01917, KAKENHI-PROJECT-15H02569
[Journal Article] Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-β-cyclodextrin2015
- Author(s)
  H.Kitagisshi, F.Chai, S.Negi. Y.Sugiuraand K.Kano
- Journal Title
  
  Chem.Commun.
  
  Volume: 51 Issue: 12 Pages: 2421-2424
- DOI
  10.1039/c4cc09042j
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390012, KAKENHI-PROJECT-26350962, KAKENHI-PROJECT-26870704
[Journal Article] Efficient cleavage of DNA oligonucleotides by a non-FokI-type zinc2015
- Author(s)
  Shigeru Negi*, Michiko Yoshioka, Hiroko Mima, Makoto Mastumoto, Michiko Suzuki, Mao Yokoyama, Koji Kano, Yukio Sugiura,
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letter
  
  Volume: 25 Issue: 19 Pages: 4074-4077
- DOI
  10.1016/j.bmcl.2015.08.045
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350962
[Journal Article] Zn(II) binding and DNA binding properties of ligand-substituted XXHH-type zinc finger proteins2012
- Author(s)
  M.Imanishi, K.Matsumura, S.Tsuji, T.Nakaya, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochemistry
  
  Volume: 51(16) Pages: 3342-3348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Rational design of DNA sequence-specific zinc fingers.2012
- Author(s)
  Kono H, Imanishi M, Negi S, Tatsutani K, Sakaeda Y, Hashimoto A, Nakayama C, Futaki S, Sugiura Y.
- Journal Title
  
  FEBS　letters
  
  Volume: 586 Issue: 6 Pages: 918-923
- DOI
  10.1016/j.febslet.2012.02.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510266, KAKENHI-PROJECT-24390012
[Journal Article] Zn(II) binding and DNA binding properties of ligand-substituted CXHH-type zinc finger proteins2012
- Author(s)
  M. Imanishi, K. Matsumura , S. Tsuji , T. Nakaya, S. Negi, S. Futaki, Y. Sugiura
- Journal Title
  
  Biochemistry
  
  Volume: Vol.24 Pages: 3342-3348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510266
[Journal Article] Zn(II) binding and DNA binding properties of ligand-substituted CXHH-type zinc　finger proteins2012
- Author(s)
  M.Imanishi
- Journal Title
  
  Biochemistry
  
  Volume: 51 Issue: 16 Pages: 3342-3348
- DOI
  10.1021/bi300236m
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085, KAKENHI-PROJECT-23510266, KAKENHI-PROJECT-24390012
[Journal Article] Rational design of DNA sequencespecific zinc fingers2012
- Author(s)
  H.Kono, M.Imanishi, S.Negi, K.Tatsutani, T.Sakaeda, A.Hashimoto, C.Nakayama, S.Futaki, Y.Sugiura
- Journal Title
  
  FEBS Lett
  
  Volume: 586(6) Pages: 918-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Rational design of DNA sequence-specific zinc fingers2012
- Author(s)
  H. Kono, M. Imanishi, S. Negi, K. Tatsutani, Y. Sakaeda, A. Hashimoto, C. Nakayama, S. Futaki, Y. Sugiura
- Journal Title
  
  FEBS Lett
  
  Volume: Vol.586 Pages: 918-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510266
[Journal Article] Rational design of DNA sequence-specific zinc fingers2011
- Author(s)
  Kono H, Imanishi M, Negi S, Tatsutani K, Sakaeda Y, Hashimoto A, Nakayama C, Futaki S, Sugiura Y.
- Journal Title
  
  FEBS letters.
  
  Volume: 586巻 Pages: 918-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510266
[Journal Article] An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domain structure and mediates DNA binding2011
- Author(s)
  S.Negi
- Journal Title
  
  Biochemistry
  
  Volume: 50巻 Issue: 28 Pages: 6366-6372
- DOI
  10.1021/bi200697p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Rational design of DNA sequence-specific zinc fingers2011
- Author(s)
  SHIGERU NEGI
- Journal Title
  
  FEBS letters.
  
  Volume: 586 Pages: 918-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510266
[Journal Article] An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domain structure and mediates DNA binding2011
- Author(s)
  S. Negi, M. Imanishi, M. Sasaki, K. Tatsutani, S. Futaki, Y. Sugiura
- Journal Title
  
  Biochemistry
  
  Volume: Vol 50 Pages: 6266-6272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510266
[Journal Article] An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domein structure and mediates DNA binding2011
- Author(s)
  S.Negi, M.Imanishi, M.Sasaki, K.Tatsutani, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochemistry
  
  Volume: 50(28) Pages: 6366-6372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp12010
- Author(s)
  M.Imanishi, C.Imamura, C.Hogashi, W.Yan, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochem.Biophys.Res.Commun
  
  Volume: 400(4) Pages: 625-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Spl, Biochem.Biophys.2010
- Author(s)
  M.Imanishi, C.Imamura, C.Higashi, W.Yan, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Res.Commun. 400(4)
  
  Pages: 625-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Zinc finger-zinc finger interaction between the transcription factors, GATA-land Sp12010
- Author(s)
  S.Negi
- Journal Title
  
  Biochem.Biophys.Res.Commun
  
  Volume: 400 Pages: 625-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] A Diatomic Molecule Receptor That Removes CO in a Living Organism2010
- Author(s)
  H. Kitagishi, S. Negi, A. Kiriyama, A. Honbo, Y. Sugiura, A. T. Kawaguchi, K. Kano
- Journal Title
  
  Angew. Chem. Int. Ed
  
  Volume: Vol.49 Pages: 1312-1315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21350097
[Journal Article] Cytochrome C polymerization by successive domain swapping at the C-termina helix625-6302010
- Author(s)
  S.Negi
- Journal Title
  
  Proc.Natl.Acad.Sci.USA.
  
  Volume: 107 Pages: 12854-12859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Spl2010
- Author(s)
  M.Imanishi, C.Imamura, C.Higashi, W.Yan, S.Negi, S.Futaki, Y.Sugiura
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 400(4) Pages: 625-630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] A diatomic molecule receptor that removes CO in a living organism2010
- Author(s)
  S.Negi
- Journal Title
  
  Angew.Chem.Int.Ed.
  
  Volume: 49 Pages: 1312-1315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] Non-FolkI-based zinc finger nucleases, Engineered Zinc Finger Proteins, Ed. by J.Markay & D.Segal2010
- Author(s)
  M.Imanishi, S.Negi, Y.Sugiura
- Journal Title
  
  Methods in Molecular Biology
  
  Pages: 337-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22651085
[Journal Article] Novel zinc finger nuclease created by combining the Cys_2His_2 and His_4 type zinc finger domain2009
- Author(s)
  S.Negi, Y.Umeda, S.Masuyama, Y.Sugiura
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19(10)
  
  Pages: 2789-2791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Novel zinc finger nuclease Created by combining the Cys_2His_2 and His_4 type zinc finger domains2009
- Author(s)
  S.Negi
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 2789-2791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Novel zinc finger nuclease created by combining the Cys_2His_2- and His_4-type zinc finger domains2009
- Author(s)
  Shigeru Negi, Yoshiyuki Umeda, Saeko Masuyama Saeko, Koji Kano, Yukio Sugiura
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letter Vol.19
  
  Pages: 2789-2791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] Novel zinc finger nuclease Created by combining the Cys_2His_2 and His_4 type zinc finger domain2009
- Author(s)
  S.Negi
- Journal Title
  
  Bioorg.Med.Chem.Lett. 19
  
  Pages: 2789-2791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] Effects of Bulkiness and Hydrophobicity of an Aliphatic Amino Acid in the Recognition2008
- Author(s)
  Muthu Dhanasekaran, Shigeru Negi, Miki Imanishi, Michiko Suzuki, Yukio Sugiura
- Journal Title
  
  Helix of the GAGA Zinc Finger on the Stability of the Hydrophobic Core and DNA Binding Affinity, Biochemistry Vol.47
  
  Pages: 11717-11724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] New redesigned zinc-finger proteins : design strategy and its application2008
- Author(s)
  S. Negi
- Journal Title
  
  Chemistry 14
  
  Pages: 3236-3246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20510206
[Journal Article] Novel redesigned zinc finger proteins : Design strategy and its application2008
- Author(s)
  S. Negi
- Journal Title
  
  Chem. Eur. J. 14
  
  Pages: 3236-3249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Novel redesigned zinc finger proteins : Design strategy and its application2008
- Author(s)
  S.Negi, M.Imanishi, M.Matsumoto, Y.Sugiura
- Journal Title
  
  Chem.Eur.J. 14(11)
  
  Pages: 3236-3249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] Effects of bulkiness and hydrophobicity of aliphatic amino acid at recognition helix of GAGA zinc finger on the stability of hydrophobic core and DNA-binding affinity2008
- Author(s)
  M.Dhanasekaran, S.Negi, M.Imanishi, M.Suzuki, Y.Sugiura
- Journal Title
  
  Biochemistry 47(45)
  
  Pages: 11717-11724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390037
[Journal Article] 新機能性亜鉛フィンガータンパク質のデザインと医学・薬学領域への展開2007
- Author(s)
  根木滋
- Journal Title
  
  ファルマシア 43
  
  Pages: 527-532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18710190
[Journal Article] 新機能性亜鉛フィンガータンパク質のデザインと医学・薬学領域への展開2007
- Author(s)
  根木滋
- Journal Title
  
  ファルマシア 43
  
  Pages: 527-532
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390028
[Journal Article] 遺伝子を標的とする亜鉛フィンガーのタンパク質工学:人工亜鉛フィンガータンパク質の創製と機能2007
- Author(s)
  根木滋
- Journal Title
  
  化学工業 57
  
  Pages: 577-581
- Data Source
  KAKENHI-PROJECT-18710190
[Journal Article] Design and Denelopment to Medical Pharmaceutical Region of New Functional Zinc Finger Proteins2007
- Author(s)
  S. Negi
- Journal Title
  
  Phamacia 43
  
  Pages: 527-532
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390028
[Journal Article] Biomolecular mirror-image recognition2006
- Author(s)
  S.Negi
- Journal Title
  
  Chirality 18 ・ 4
  
  Pages: 254-258
- Data Source
  KAKENHI-PROJECT-18710190
[Journal Article] 人工亜鉛フィンガーによる遺伝子発現の制御2006
- Author(s)
  根木滋
- Journal Title
  
  化学 61・8
  
  Pages: 68-69
- Data Source
  KAKENHI-PROJECT-18710190
[Journal Article] 人工亜鉛フィンガーによる遺伝子発現の制御2006
- Author(s)
  根木滋
- Journal Title
  
  化学 61・8
  
  Pages: 68-69
- Data Source
  KAKENHI-PROJECT-17390028
[Journal Article] 遺伝子を標的とする亜鉛フィンガーのタンパク質工学2006
- Author(s)
  根木滋
- Journal Title
  
  化学工業 57・8
  
  Pages: 577-582
- Data Source
  KAKENHI-PROJECT-17390028
[Journal Article] Biomolecular mirror-image recognition2006
- Author(s)
  S.Negi
- Journal Title
  
  Chirality 18.4
  
  Pages: 254-258
- Data Source
  KAKENHI-PROJECT-17390028
[Journal Article] 遺伝子を標的とする亜鉛フィンガーのタンパク質工学2006
- Author(s)
  根木滋
- Journal Title
  
  化学工業 57・8
  
  Pages: 577-582
- Data Source
  KAKENHI-PROJECT-18710190
[Presentation] 生体内COの除去による体内時計の変化2018
- Author(s)
  北岸宏亮，峯岸彩夏, 佐上郁子，根木滋，加納航治
- Organizer
  第12回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-17H02208
[Presentation] 生体内一酸化炭素の選択的除去が及ぼす体内時計システムへの影響2018
- Author(s)
  北岸宏亮，峯岸彩夏, 佐上郁子，根木滋，加納航治
- Organizer
  第25回日本血液代替物学会年次大会
- Data Source
  KAKENHI-PROJECT-17H02208
[Presentation] 生体内COの除去による体内時計の変化2018
- Author(s)
  北岸宏亮，峯岸彩夏, 佐上郁子，根木滋，加納航治
- Organizer
  第6回バイオ関連シンポジウム
- Data Source
  KAKENHI-PROJECT-17H02208
[Presentation] GAGA metallo finger peptides; Its metal-binding, DNA-binding and Redox properties2013
- Author(s)
  Shigeru Negi, Sugiura Yukio
- Organizer
  International conference on biological inorganic chemistry (ICBIC 16)
- Place of Presentation
  Grenoble (France)
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] GAGA metallo finger peptides: Its metal-binding, DNA-binding and redox propertses2013
- Author(s)
  S.Negi and Y.Sugiura
- Organizer
  XVI International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Grenoble, France
- Data Source
  KAKENHI-PROJECT-24390012
[Presentation] GAGA Metallofinger Peptides: Its Metal-binding, DNA-binding and Redox Properties2012
- Author(s)
  S. Negi, Y. Sugiura
- Organizer
  The 6th Asian Biological Inorganic Chemistry Conference (AsBIC-VI)
- Place of Presentation
  Polytechnic University（Hong Kong）
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] Control of DNA Binding of Transcription Factors by an Porphyrin-Cyclodextrin Supramolecular Complex2012
- Author(s)
  S. Negi, T. Ogasawara, H. Iede, Y. Sugiura
- Organizer
  International Conference on Porphyrins and Phthalocyanines (ICCP7)
- Place of Presentation
  国際コンベンションセンター（ICC）済州（Jeju, Korea）
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] GAGA metallofinger peptide: Its metal-binding, DNA-binding and redox properties2012
- Author(s)
  根木　滋
- Organizer
  6th ABICC
- Place of Presentation
  Hong Kong
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] 亜鉛フィンガータンパク質のレドックス挙動2012
- Author(s)
  根木滋
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  慶應大学日吉キャンパス(神奈川県)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-24390012
[Presentation] 亜鉛フィンガータンパク質のレドックス挙動2012
- Author(s)
  根木滋、山岡槇子、福田あずさ、杉浦幸雄
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  横浜市
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] Redesigned Zinc Finger Proteins : Design Strategy and Its Application2011
- Author(s)
  S.Negi
- Organizer
  Pepcom2011
- Place of Presentation
  北京
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-20510206
[Presentation] 新規GAGA金属置換型フィンガーの創製およびその機能評価2011
- Author(s)
  増山紗永子、根木滋、野口範子、杉浦幸雄
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  横浜市
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] Redesign strategy to create of artificial zinc finger proteins2011
- Author(s)
  Negi S, Sugiura Y.
- Organizer
  22nd American Peptide Symposium
- Place of Presentation
  Sheraton San Diego Hoteland Marina (USA)
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] 人工亜鉛フィンガータンパク質のデザインおよびその機能2011
- Author(s)
  根木滋、谷口仁哉、杉浦幸雄
- Organizer
  第36回生体分子科学討論会
- Place of Presentation
  札幌市
- Year and Date
  2011-06-19
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] Study on cell penetrating of GAGA zinc finger protein2011
- Author(s)
  SHIGERU NEGI
- Organizer
  22^<nd> American Peptide Symposium
- Place of Presentation
  Sheraton San Diego Hotel and Marina San Diego, CA(米国)
- Year and Date
  2011-06-28
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] GAGA亜鉛フィンガータンパク質の酸化に伴う構造および機能変化2011
- Author(s)
  根木滋、増山紗永子、山岡槇子、杉浦幸雄
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  横浜市
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] Study on cell penetrating of GAGA zinc finger protein2011
- Author(s)
  Negi S, Terada Y. Negi S.
- Organizer
  22nd American Peptide Symposium
- Place of Presentation
  Sheraton San Diego Hoteland Marina (USA)
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] Redesign strategy to create of artificial zinc finger proteins2011
- Author(s)
  SHIGERU NEGI
- Organizer
  22^<nd> American Peptide Symposium
- Place of Presentation
  Sheraton San Diego Hotel and Marina San Diego, CA(米国)
- Year and Date
  2011-06-26
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] リデザインによる野生型亜鉛フィンガー蛋白質の機能変換2010
- Author(s)
  根木滋、三間紘子、杉浦幸雄
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌市
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] リデザインによる野生型亜鉛フィンガータンパク質の機能変換2010
- Author(s)
  根木滋
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌市
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22651085
[Presentation] リデザインによる野生型亜鉛フィンガータンパク質の機能改変:人工亜鉛フィンガー型ヌクレアーゼの創生2010
- Author(s)
  根木滋、三間紘子、杉浦幸雄
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌市
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20390037
[Presentation] Non FokI-type zinc finger nuclease2009
- Author(s)
  根木滋
- Organizer
  14^<th> International Conference on Biological Inorganic Chemistry
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20510206
[Presentation] DNA結合におけるGAGA亜鉛フィンガードメイン疎水性コアの重要性2009
- Author(s)
  根木滋
- Organizer
  日本化学会第89回春季年会(2009)
- Place of Presentation
  日本大学
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-20510206
[Presentation] Non FokI-type zinc finger nuclease2008
- Author(s)
  Shigeru Negi, Yukio Sugiura
- Organizer
  14th International Conference on Biological Inorganic Chemistry (ICBIC14)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-20510206
[Presentation] 酵素機能を有する人工亜鉛フィンガータンパク質の創製2007
- Author(s)
  根木滋
- Organizer
  第22回生体機能化学関連化学シンポジウム
- Place of Presentation
  仙台市
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-18710190
[Presentation] 亜鉛フィンガータンパク質の新しい機能に関する研究
- Author(s)
  根木　滋、　杉浦　幸雄
- Organizer
  第50回同志社大学理工学研究所研究発表会、2012年度学内研究センター合同シンポジウム
- Place of Presentation
  同志社大学（京都府）
- Invited
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] 亜鉛フィンガータンパク質の最近の研究動向および今後の展開
- Author(s)
  根木　滋、　杉浦　幸雄
- Organizer
  ナノ・バイオサイエンス研究センターstart-up講演会
- Place of Presentation
  同志社大学(京都府）
- Invited
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] 超分子ヘムタンパク質モデル化合物による生体内ＣＯの除去
- Author(s)
  北岸宏亮、根木　滋、勇村亞希、杉浦幸雄、加納航治
- Organizer
  第41回生体分子科学討論会
- Place of Presentation
  九州大学西新プラザ(福岡市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26350962
[Presentation] GAGA metallo finger peptides; Its metal-binding, DNA-binding and Redox properties
- Author(s)
  Shigeru Negi, Yukio Sugiura
- Organizer
  International conference on biological inorganic chemistry (ICBIC 16)
- Place of Presentation
  Grenoble
- Data Source
  KAKENHI-PROJECT-23510266
[Presentation] Sp1亜鉛フィンガーの各フィンガードメインにおけるレドックス応答の非対称性
- Author(s)
  根木滋、福田あずさ、鎌手裕実香、杉浦幸雄
- Organizer
  第41回生体分子科学討論会
- Place of Presentation
  九州大学西新プラザ、福岡市
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24390012
[Presentation] Sp1亜鉛フィンガーの各フィンガードメインにおけるレドックス応答の非対称性
- Author(s)
  根木　滋、福田あずさ、鎌手裕美香、杉浦幸雄
- Organizer
  第41回生体分子科学討論会
- Place of Presentation
  九州大学西新プラザ(福岡市）
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26350962
[Presentation] Redesigned Zinc Finger Proteins : Design Strategy and Its Application
- Author(s)
  Shigeru Negi, Yukio Sugiura
- Organizer
  Pepcom2011 (Beijing)
- Place of Presentation
  Invited Lecture
- Data Source
  KAKENHI-PROJECT-20510206
[Presentation] Design of artificial zinc finger nuclease based on unnatural His4-type zinc finger catalytic domain
- Author(s)
  Shigeru Negi, Yukio Sugiura
- Organizer
  Pacifichem 2010
- Place of Presentation
  Hawaii
- Data Source
  KAKENHI-PROJECT-20510206
[Presentation] Control of DNA-binding of GAL4 zinc finger by porphyrin-cyclodextrin supramolecular system
- Author(s)
  Shigeru Negi、Koji Kano, Yukio Sugiura
- Organizer
  ICCP-8
- Place of Presentation
  Istanbul(Turkey)
- Year and Date
  2014-06-22 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26350962

1. SUGIURA Yukio (40025698)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. KANO Koji (60038031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. KAWAGUCHI Akira (30195052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. IMANISHI Miki (80362391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Hiroaki Kitagishi (60448090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 佐上郁子 (10143033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

NEGI Shigeru 根木 滋

Research Projects

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Co-Researchers

Study on the role of endogenous CO in the circadian clock system

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Investigation of new zinc finger protein function as a redox sensor for reactive oxygen in the cellsPrincipal Investigator

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Specific DNA Recognition by Fluctuation of Zinc Finger Protein and Development for Smart Transcription Factor

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Structural and functional analysis of zinc finger protein in metal binding and redox reactionPrincipal Investigator

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Creation of First Enzyme-Type Zinc Finger Protein PossessingCatalytic Function

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Capture of diatomic molecules by supramolecular heme protein models and application to development to medicinal chemistry

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Creation and Pharmaceutical Development of Intelligent Zinc Fingers Based on Genomic Chemistry

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Creation of artificial peptidase based on zinc finger frameworkPrincipal Investigator

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触媒作用を有する人工金属フィンガータンパク質の創製Principal Investigator

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Creation of New Functional Artificial Metallofingers : Construction of Library and Development to Gene Regulation

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[Book] "Non-FokI-based zinc finger nuclease" in Engineered Zinc Finger proteins2010

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[Book] Engineered Zinc Figer Proteins(Eds.by J.P.Mackey, D.J.Segal)(Non-FolkI-based zinc finger nucleases)2010

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[Book] Non-FokI-based zinc finger nuclease(Engineered Zinc Finger proteins, <Eds. by J. Mackay and D. Segal>, Methods in Molecular Biology, Vol.649)

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[Journal Article] Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per‐ O ‐Methylated β‐Cyclodextrin Cavity in Serum, Blood, and Urine2019

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DOI

NEGI Shigeru 根木滋

[Journal Article] Zn(II) binding and DNA binding properties of ligand-substituted CXHH-type zinc　finger proteins2012