Oshiumi Hiroyuki 押海裕之

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OSHIUMI Hiroyuki 押海裕之

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Researcher Number	50379103
Other IDs
External Links
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 熊本大学, 大学院生命科学研究部(医), 教授 2019 – 2021: 熊本大学, 大学院生命科学研究部(医), 教授 2015 – 2017: 熊本大学, 大学院生命科学研究部(医), 教授 2014: 北海道大学, 人獣共通感染症リサーチセンター, 准教授 2014: 北海道大学, 学内共同利用施設等, 准教授 … More 2013: 北海道大学, 大学院・大医学研究科, 講師 2012 – 2013: 北海道大学, 医学(系)研究科(研究院), 講師 2009 – 2011: Hokkaido University, 大学院・医学研究科, 講師 2007 – 2008: Hokkaido University, 大学院・医学研究科, 助教 2006: 阪大, たんぱく質研究所, 助手 2005: 大阪大学, 蛋白質研究所, 助手 Less
Review Section/Research Field	Principal Investigator Immunology / Biological Sciences / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 54030:Infectious disease medicine-related / Basic Section 49060:Virology-related / Molecular biology / Biological Sciences Except Principal Investigator Immunology / Biological Sciences
Keywords	Principal Investigator ウイルス / 自然免疫 / インターフェロン / I型インターフェロン / ユビキチン / RIG-I / 免疫 / C型肝炎 / 核酸 / 感染症 … More / サイトカイン / エクソソーム / シグナル / Riplet / 炎症性サイトカイン / 細胞周期 / DNA修復 / microRNA / ワクチン / 代謝 / 糖尿病 / 代謝異常 / 肥満 / 代謝異常症 / 自然免役 / Ｂ型肝炎 / Ｃ型肝炎 / 細胞外小胞 / C型肝炎ウイルス / 肝炎 / ヘリケース / 炎症 / インフルエンザ / DDX3 / 遺伝病 / RNA / 生体防御 / 酵母 / 組換え / 相同組換え / 出芽酵母 / サイクリン依存性リン酸化酵素 / 遺伝的組換え / サイクリン / 癌 … More Except Principal Investigator Toll-like receptor / IPS-1 / TICAM-1 / 樹状細胞 / 自然免疫 / poliovirus / HCV / 細胞性免疫 / インターフェロン / RNAウイルス / Toll-like-receptor / RNAアジュバント Less

ワクチン接種後の免疫応答の個人差を決める重要な要因としてのエクソソームPrincipal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kumamoto University
代謝異常がウイルスに対する自然免疫を制御する新たなメカニズムの解明Principal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Study of innate immune responses against viral infectionPrincipal Investigator
- Principal Investigator
  
  Oshiumi Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kumamoto University
Novel interaction between virus and host innate immune systemPrincipal Investigator
- Principal Investigator
  
  OSHIUMI HIROYUKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kumamoto University
自然免疫系の細胞質内核酸認識経路が自然炎症を引き起こす仕組みPrincipal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Novel molecular mechanisms of antiviral innate immune responsePrincipal Investigator
- Principal Investigator
  
  OSHIUMI Hiroyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
Molecular mechanisms of dendritic cell maturation in response to pattern sensing
- Principal Investigator
  
  SEYA Tsukasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
自然免疫に於ける未知の微生物認識分子群の単離と炎症への繋がりの解明Principal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
In vivo role of novel innate immune factors during viral infectionPrincipal Investigator
- Principal Investigator
  
  OSHIUMI Hiroyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
Isolation and analysis of novel molecules that recognize viral infectionPrincipal Investigator
- Principal Investigator
  
  OSHIUMI Hiroyuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
ウイルス感染のRNA応答
- Principal Investigator
  
  SEYA Tsukasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
限られた時間内に相同組換えが終わる仕組みと、組換えの新たな展開Principal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Hokkaido University
  Osaka University
サイクリンが遺伝的組換えを制御し癌を抑制する仕組みPrincipal Investigator
- Principal Investigator
  
  押海裕之
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University

[Book] Oligomerization in Health and Diseases.2013
- Author(s)
  Matsumoto, M., K. Funami, H. Oshiumi, and T. Seya
- Publisher
  Academic Press, ELSEVIER INC.
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023
- Author(s)
  Toyoda Mako、Tan Toong Seng、Motozono Chihiro、Barabona Godfrey、Yonekawa Akiko、Shimono Nobuyuki、Minami Rumi、Nagasaki Yoji、Miyashita Yusuke、Oshiumi Hiroyuki、Nakamura Kimitoshi、Matsushita Shuzo、Kuwata Takeo、Ueno Takamasa
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 4 Pages: 00660-23
- DOI
  10.1128/spectrum.00660-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1775, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K07089, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24378, KAKENHI-PROJECT-23K27640
[Journal Article] LINE-1 hypomethylation, increased retrotransposition and tumor-specific insertion in upper gastrointestinal cancer2023
- Author(s)
  Baba Y, Yasuda N, Bundo M, Nakachi Y, Ueda J, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Oshiumi H, Iwamoto K, Baba H.
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 1 Pages: 247-256
- DOI
  10.1111/cas.16007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27640
[Journal Article] HPV vaccines induce trained immunity and modulate pro‐inflammatory cytokine expression in response to secondary Toll‐like receptor stimulations2023
- Author(s)
  Yamaguchi Mako、Mtali Yohana S.、Sonokawa Hitomi、Takashima Ken、Fukushima Yoshimi、Kouwaki Takahisa、Oshiumi Hiroyuki
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 68 Issue: 2 Pages: 65-74
- DOI
  10.1111/1348-0421.13108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15498, KAKENHI-PUBLICLY-22H05603, KAKENHI-PROJECT-23K27640
[Journal Article] Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection.2022
- Author(s)
  Tsutsuki Hiroyasu, Zhang Tianli, Yahiro Kinnosuke, Ono Katsuhiko, Fujiwara Yukio, Iyoda Sunao, Wei Fan-Yan, Monde Kazuaki, Seto Kazuko, Ohnishi Makoto, Oshiumi Hiroyuki, Akaike Takaaki, Sawa Tomohiro.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 4 Pages: 104050-104050
- DOI
  10.1016/j.isci.2022.104050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21496, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-20F20408, KAKENHI-PROJECT-20K07506, KAKENHI-PROJECT-20K08823, KAKENHI-PROJECT-22K05443, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-17H06170
[Journal Article] Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination.2022
- Author(s)
  Miyashita Y, Yoshida T, Takagi Y, Tsukamoto H, Takashima K, Kouwaki T, Makino K, Fukushima S, Nakamura K, Oshiumi H.
- Journal Title
  
  NPJ Vaccines
  
  Volume: 7 Issue: 1 Pages: 16-16
- DOI
  10.1038/s41541-022-00439-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-21K08351, KAKENHI-PUBLICLY-22H05603, KAKENHI-PROJECT-20K08259, KAKENHI-PROJECT-21K20841
[Journal Article] Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats2022
- Author(s)
  Oka K, Fujioka S, Kawamura Y, Komohara Y, Chujo T, Sekiguchi K, Yamamura Y, Oiwa Y, Omamiuda-Ishikawa N, Komaki S, Sutoh Y, Sakurai S, Tomizawa K, Bono H, Shimizu A, Araki K, Yamamoto T, Yamada Y, Oshiumi H, Miura K.
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 287-287
- DOI
  10.1038/s42003-022-03241-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-20H03187, KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K21285
[Journal Article] TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor-mediated inflammatory responses2021
- Author(s)
  Miyashita Y, Kouwaki T, Tsukamoto H, Okamoto M, Nakamura K, Oshiumi H.
- Journal Title
  
  Life Sci Alliance
  
  Volume: 5 Issue: 2 Pages: e202101181-e202101181
- DOI
  10.26508/lsa.202101181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-21H02788
[Journal Article] RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses2021
- Author(s)
  Kouwaki T, Nishimura T, Wang G, Oshiumi H.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 700926-700926
- DOI
  10.3389/fimmu.2021.700926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480
[Journal Article] Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication2021
- Author(s)
  Fukuda Hiroyuki、Chujo Takeshi、Wei Fan-Yan、Shi Sheng-Lan、Hirayama Mayumi、Kaitsuka Taku、Yamamoto Takahiro、Oshiumi Hiroyuki、Tomizawa Kazuhito
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 20 Pages: 11855-11867
- DOI
  10.1093/nar/gkab879
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05309, KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-20H03187
[Journal Article] Export of RNA-derived modified nucleosides by equilibrative nucleoside transporters defines the magnitude of autophagy response and Zika virus replication2021
- Author(s)
  Shi Sheng-Lan、Fukuda Hiroyuki、Chujo Takeshi、Kouwaki Takahisa、Oshiumi Hiroyuki、Tomizawa Kazuhito、Wei Fan-Yan
- Journal Title
  
  RNA Biology
  
  Volume: 18 Issue: sup1 Pages: 478-495
- DOI
  10.1080/15476286.2021.1960689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05309, KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-20H03187
[Journal Article] Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly2020
- Author(s)
  Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 9 Pages: 101520-101520
- DOI
  10.1016/j.isci.2020.101520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-18K07325
[Journal Article] Recent Advances and Contradictions in the Study of the Individual Roles of Ubiquitin Ligases That Regulate RIG-I-Like Receptor-Mediated Antiviral Innate Immune Responses2020
- Author(s)
  Hiroyuki Oshiumi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1296-1296
- DOI
  10.3389/fimmu.2020.01296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480
[Journal Article] Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells2019
- Author(s)
  Wang Guanming、Kouwaki Takahisa、Mugikura Kazuki、Okamoto Masaaki、Takaki Hiromi、Funami Kenji、Seya Tsukasa、Oshiumi Hiroyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 50 Pages: 18969-18979
- DOI
  10.1074/jbc.ra119.009783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03480
[Journal Article] Immune-regulatory microRNA expression levels within circulating extracellular vesicles correspond with the appearance of local symptoms after seasonal flu vaccination2019
- Author(s)
  Miyashita Yusuke、Ishikawa Kana、Fukushima Yoshimi、Kouwaki Takahisa、Nakamura Kimitoshi、Oshiumi Hiroyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 7 Pages: e0219510-e0219510
- DOI
  10.1371/journal.pone.0219510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480
[Journal Article] Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I2019
- Author(s)
  Wang Guanming、Kouwaki Takahisa、Okamoto Masaaki、Oshiumi Hiroyuki
- Journal Title
  
  Cell Reports
  
  Volume: 28 Issue: 8 Pages: 1961-1970.e4
- DOI
  10.1016/j.celrep.2019.07.081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480
[Journal Article] TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells2018
- Author(s)
  Takashima Ken、Oshiumi Hiroyuki、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 499 Issue: 4 Pages: 985-991
- DOI
  10.1016/j.bbrc.2018.04.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Regulation of RIG-I Activation by K63-Linked Polyubiquitination2018
- Author(s)
  Okamoto Masaaki、Kouwaki Takahisa、Fukushima Yoshimi、Oshiumi Hiroyuki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 8 Pages: 1942-1942
- DOI
  10.3389/fimmu.2017.01942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells2018
- Author(s)
  Fukushima Yoshimi、Okamoto Masaaki、Ishikawa Kana、Kouwaki Takahisa、Tsukamoto Hirotake、Oshiumi Hiroyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: In Press Issue: 3 Pages: 744-750
- DOI
  10.1016/j.bbrc.2018.04.146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-18K07325
[Journal Article] Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling2017
- Author(s)
  Funami Kenji、Matsumoto Misako、Oshiumi Hiroyuki、Inagaki Fuyuhiko、Seya Tsukasa
- Journal Title
  
  Biochemical Society Transactions
  
  Volume: 45 Issue: 4 Pages: 929-935
- DOI
  10.1042/bst20160259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Extracellular vesicles deliver host and virus RNA and regulate innate immune response.2017
- Author(s)
  Kouwaki T., Okamoto M., Tsukamoto H., Fukushima Y. and Oshiumi H.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 3 Pages: 666-666
- DOI
  10.3390/ijms18030666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430165, KAKENHI-PROJECT-15K08517
[Journal Article] Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.2017
- Author(s)
  Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Matsumoto M, Seya T, Oshiumi H.
- Journal Title
  
  Scientific Reports.
  
  Volume: ー Issue: 1 Pages: 11905-11905
- DOI
  10.1038/s41598-017-12224-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15731, KAKENHI-PROJECT-15K08517
[Journal Article] Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity2017
- Author(s)
  Tsukamoto Hirotake、Fujieda Koji、Senju Satoru、Ikeda Tokunori、Oshiumi Hiroyuki、Nishimura Yasuharu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 523-530
- DOI
  10.1111/cas.13433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-18K07325
[Journal Article] cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue2017
- Author(s)
  Takaki Hiromi、Takashima Ken、Oshiumi Hiroyuki、Ainai Akira、Suzuki Tadaki、Hasegawa Hideki、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  Medical Sciences
  
  Volume: 5 Issue: 4 Pages: 35-35
- DOI
  10.3390/medsci5040035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08386, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K19134
[Journal Article] Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections2017
- Author(s)
  Okamoto Masaaki、Tsukamoto Hirotake、Kouwaki Takahisa、Seya Tsukasa、Oshiumi Hiroyuki
- Journal Title
  
  Viral Immunology
  
  Volume: 30 Issue: 6 Pages: 408-420
- DOI
  10.1089/vim.2016.0178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP702017
- Author(s)
  Takashima Ken、Oshiumi Hiroyuki、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  Journal of Innate Immunity
  
  Volume: 10 Issue: 1 Pages: 44-55
- DOI
  10.1159/000480740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06486, KAKENHI-PROJECT-15K08517
[Journal Article] Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production2017
- Author(s)
  Takaki H、Kure S、Oshiumi H、Sakoda Y、Suzuki T、Ainai A、Hasegawa H、Matsumoto M、Seya T
- Journal Title
  
  Mucosal Immunology
  
  Volume: 11 Issue: 1 Pages: 82-96
- DOI
  10.1038/mi.2017.48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08386, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K19134
[Journal Article] Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection2017
- Author(s)
  Fujikura Daisuke、Muramatsu Daisuke、Toyomane Kochi、Chiba Satoko、Daito Takuji、Iwai Atsushi、Kouwaki Takahisa、Okamoto Masaaki、Higashi Hideaki、Kida Hiroshi、Oshiumi Hiroyuki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 163 Issue: 1 Pages: 31-38
- DOI
  10.1093/jb/mvx062
- NAID
  40021457359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08570, KAKENHI-PROJECT-17J01377, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-17H01679
[Journal Article] Development of mouse models for analysis of human virus infections2017
- Author(s)
  Takaki Hiromi、Oshiumi Hiroyuki、Shingai Masashi、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 61 Issue: 3-4 Pages: 107-113
- DOI
  10.1111/1348-0421.12477
- NAID
  40021175296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K19134
[Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017
- Author(s)
  Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue J.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 13 Issue: 12 Pages: e1006162-e1006162
- DOI
  10.1371/journal.ppat.1006162
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01553, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26290036, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-26000014
[Journal Article] Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy.2016
- Author(s)
  Azuma M, Takeda Y, Nakajima H, Sugiyama H, Ebihara T, Oshiumi H, Matsumoto M, Seya T
- Journal Title
  
  OncoImmunology
  
  Volume: 8 Issue: 8 Pages: e1188244-e1188244
- DOI
  10.1080/2162402x.2016.1188244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15J02429, KAKENHI-PROJECT-15K08517
[Journal Article] Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection.2016
- Author(s)
  Takahisa Kouwaki, Yoshimi Fukushima, Takuji Daito, Takahiro Sanada, Naoki Yamamoto, Edin J. Mifsud, Chean Ring Leong, Kyoko Tsukiyama-Kohara, Michinori Kohara, Misako Matsumoto, Tsukasa Seya and *Hiroyuki Oshiumi
- Journal Title
  
  Frontiers in Immunology.
  
  Volume: 7 Pages: 335-335
- DOI
  10.3389/fimmu.2016.00335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15K08517
[Journal Article] Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response2016
- Author(s)
  Oshiumi H, Kouwaki T, Seya T
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 7 Pages: 200-200
- DOI
  10.3389/fimmu.2016.00200
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of Hepatitis B virus to impede the replication of HBV in vitro and in vivo.2016
- Author(s)
  Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Aly HH, Watashi K, Chayama K, Seya T.
- Journal Title
  
  Oncotarget.
  
  Volume: 7 Issue: 42 Pages: 68179-68193
- DOI
  10.18632/oncotarget.11907
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15293, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K19134
[Journal Article] STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation2016
- Author(s)
  Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, Seya T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 478 Issue: 4 Pages: 1764-1771
- DOI
  10.1016/j.bbrc.2016.09.021
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K08704, KAKENHI-ORGANIZER-25112001
[Journal Article] The dataset of proteins specifically interacted with activated TICAM-12016
- Author(s)
  Funami K, Matsumoto M, Oshiumi H, Obuse C, Seya T.
- Journal Title
  
  Data Brief
  
  Volume: 8 Pages: 697-699
- DOI
  10.1016/j.dib.2016.06.030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.2016
- Author(s)
  Kasamatsu, J., Deng, M., Matsumoto, M., Azuma, M., Funami, K., Shime, H., Kasahara, M., Oshiumi, H. and Seya, T.
- Journal Title
  
  BMC Immunol.
  
  Volume: 17 Issue: 1 Pages: 9-9
- DOI
  10.1186/s12865-016-0147-y
- NAID
  120005766743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04716, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K08704
[Journal Article] PolyI:C-induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo2015
- Author(s)
  Ryo Takemura, Hiromi Takaki, Seiji Okada, Hiroaki Shime, Takashi Akazawa, Hiroyuki Oshiumi, Misako Matsumoto, Takanori Teshima, and Tsukasa Seya
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 3 Issue: 8 Pages: 902-914
- DOI
  10.1158/2326-6066.cir-14-0219
- NAID
  120005820710
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-24590500, KAKENHI-PROJECT-26860593
[Journal Article] Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)2015
- Author(s)
  Masato Nakai , Hiroyuki Oshiumi , Kenji Funami, Masaaki Okamoto, Misako Matsumoto, Tsukasa Seya, and Naoya Sakamoto
- Journal Title
  
  Sensors
  
  Volume: 15 Issue: 10 Pages: 27160-27173
- DOI
  10.3390/s151027160
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model2015
- Author(s)
  Leong CR, Oshiumi H, Okamoto M, Azuma M, Takaki H, Matsumoto M, Chayama K, Seya T
- Journal Title
  
  J Innate Immunology
  
  Volume: 7 Issue: 1 Pages: 47-58
- DOI
  10.1159/000365113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-26860593
[Journal Article] RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response2015
- Author(s)
  Ken Takashima, Hiroyuki Oshiumi, Hiromi Takaki, Misako Matsumoto, Tsukasa Seya
- Journal Title
  
  Cell Reports
  
  Volume: 11 Issue: 2 Pages: 192-200
- DOI
  10.1016/j.celrep.2015.03.027
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Links between recognition and degradation of cytoplasmic viral RNA in innate immune response2015
- Author(s)
  Hiroyuki Oshiumi, Edin J Mifsud, and Takuji Daito
- Journal Title
  
  Reviews in Medical Virology
  
  Volume: 26 Issue: 2 Pages: 90-101
- DOI
  10.1002/rmv.1865
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-22015
- Author(s)
  Kenji Funami, Misako Matsumoto, Yoshiaki Enokizono, Noriko Ishii, Megumi Tatematsu, Hiroyuki Oshiumi, Fuyuhiko Inagaki and Tsukasa Seya
- Journal Title
  
  The Journal of Immunology
  
  Volume: 195 Issue: 9 Pages: 4456-4465
- DOI
  10.4049/jimmunol.1402628
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation2015
- Author(s)
  Hiroyuki Oshiumi, Moeko Miyashita, Masaaki Okamoto, Yuka Morioka, Masaru Okabe, Misako Matsumoto, Tsukasa Seya
- Journal Title
  
  Cell Reports
  
  Volume: 11 Issue: 8 Pages: 1193-1207
- DOI
  10.1016/j.celrep.2015.04.047
- NAID
  120005625293
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517
[Journal Article] Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog2015
- Author(s)
  Haruko Sato, Hiroyuki Oshiumi, Hiromi Takaki, Hirokazu Hikono, and Tsukasa Seya
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 59 Issue: 10 Pages: 633-640
- DOI
  10.1111/1348-0421.12322
- NAID
  120005906889
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-26860593
[Journal Article] Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models2014
- Author(s)
  Hiromi Takaki, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya
- Journal Title
  
  The international Journal of Biochemistry & Cell Biology
  
  Volume: 53 Pages: 329-333
- DOI
  10.1016/j.biocel.2014.05.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-26860593
[Journal Article] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic : polycytidylic acid treatment in mouse tumor models2014
- Author(s)
  Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T
- Journal Title
  
  J Innate Immun
  
  Volume: 6 Pages: 293-305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells2014
- Author(s)
  Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T
- Journal Title
  
  Mol Immunol
  
  Volume: 57(2) Pages: 100-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection2014
- Author(s)
  Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T
- Journal Title
  
  J Immunol
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] IPS-1 Is Essential for Type III IFN Production by Hepetocytes and bendritic Cells in Response to Hepatitis C Virus Infection.2014
- Author(s)
  Masaaki Okamoto, et al.
- Journal Title
  
  Journal of immunology
  
  Volume: 192 Issue: 6 Pages: 2770-7
- DOI
  10.4049/jimmunol.1301459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J01978, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214
[Journal Article] MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Ta mouse bone marrow-derived dendritic cells.2014
- Author(s)
  Hiromi Takaki, et al.
- Journal Title
  
  Molecular Immunology
  
  Volume: 57 Issue: 2 Pages: 100-110
- DOI
  10.1016/j.molimm.2013.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214, KAKENHI-PROJECT-26860593
[Journal Article] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor model.2014
- Author(s)
  Shime, H., A. Kojima, A. Maruyama, Y. Saito, H. Oshiumi, M. Matsumoto, and T. Seya.
- Journal Title
  
  J. Innate. Immun.
  
  Volume: 6 Issue: 3 Pages: 293-305
- DOI
  10.1159/000355126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24590570
[Journal Article] INAM Plays a Critical Role in IFN-gamma Production by NK Cells Interacting with Polyinosinic-Polycytidylic Acid-Stimulated Accessory Cells.2014
- Author(s)
  Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M, Ebihara T, Matsumoto M, Seya T
- Journal Title
  
  Journal of Immunology
  
  Volume: 193 Issue: 10 Pages: 5199-5207
- DOI
  10.4049/jimmunol.1400924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240066, KAKENHI-PROJECT-24590570
[Journal Article] Cell-type specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA2013
- Author(s)
  Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 12 Pages: e83639-e83639
- DOI
  10.1371/journal.pone.0083639
- NAID
  120005372326
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570
[Journal Article] Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA2013
- Author(s)
  Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T
- Journal Title
  
  PLoS One
  
  Volume: 8(12)
- NAID
  120005372326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses2013
- Author(s)
  Oshiumi H, Miyashita M, Matsumoto M, Seya T
- Journal Title
  
  PLoS Pathog
  
  Volume: 9(8)
- NAID
  120005326762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Riplet ubiquitin ligase plays a pivotal role in TRIM25-mediated RIG-I activation and is targeted by Hepatitis C Virus.2013
- Author(s)
  Oshiumi, H., M. Miyashita, M. Matsumoto, and T. Seya
- Journal Title
  
  PLoS Pathog.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.2013
- Author(s)
  Oshiumi H, Miyashita M, Matsumoto M, Seya T.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 9(8) Issue: 8 Pages: e1003533-e1003533
- DOI
  10.1371/journal.ppat.1003533
- NAID
  120005326762
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214
[Journal Article] Multi-step regulation of interferon induction by hepatitis C virus2013
- Author(s)
  Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T
- Journal Title
  
  Arch Immunol Ther Exp (Warsz)
  
  Volume: 61(2) Pages: 127-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The MyD88 pathway in plasmacytoide and CO4+ dendritic cells primarily triggers type I interferon production against measles virus in a mouse infection model.2013
- Author(s)
  Hiromi Takaki, et al.
- Journal Title
  
  Journal of Immunolog
  
  Volume: 191 Issue: 9 Pages: 4740-4747
- DOI
  10.4049/jimmunol.1301744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J40020, KAKENHI-PROJECT-22790445, KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590570
[Journal Article] Multi-step regulation of interferon induction by hepatitis C virus.2013
- Author(s)
  Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T.
- Journal Title
  
  Arch Immunol Ther Exp (Warsz)
  
  Volume: 61(2) Issue: 2 Pages: 127-138
- DOI
  10.1007/s00005-012-0214-x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model2013
- Author(s)
  Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T
- Journal Title
  
  J Immunol
  
  Volume: 191(9) Pages: 4740-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.2013
- Author(s)
  Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.
- Journal Title
  
  J Immunol.
  
  Volume: 191(9) Pages: 4740-4747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis.2012
- Author(s)
  Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M.
- Journal Title
  
  Oncoimmunol.
  
  Volume: 1 Issue: 6 Pages: 917-923
- DOI
  10.4161/onci.21244
- NAID
  120005228664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214, KAKENHI-PUBLICLY-24117702
[Journal Article] Cross-presentation and antitumor CTL induced by soluble Ag + polyI:C largely depend on the TICAM-1 pathway in mouse CD11c+/CD8a+ dendritic cells.2012
- Author(s)
  Azuma M., T. Ebihara, H. Oshiumi, M. Matsumoto, and T. Seya.
- Journal Title
  
  OncoImmunol.
  
  Volume: 1 Issue: 5 Pages: 581-592
- DOI
  10.4161/onci.19893
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214, KAKENHI-PUBLICLY-24117702
[Journal Article] Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I2012
- Author(s)
  Oshiumi, H., M.Matsumoto, T.Seya
- Journal Title
  
  J.Biochem.
  
  Volume: 151 Issue: 1 Pages: 5-11
- DOI
  10.1093/jb/mvr111
- NAID
  10031166037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
- Author(s)
  H.Shime
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Issue: 6 Pages: 2066-2071
- DOI
  10.1073/pnas.1113099109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-21200079, KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21590326, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790371, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24659214
[Journal Article] The Toll-like receptor 3-mediayed antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice2012
- Author(s)
  Abe, Y., K.Fujii, N.Nagata, O.Takeuchi, S.Akira, H.Oshiumi, M.Matsumoto, T.Seya, S.Koike
- Journal Title
  
  J.Virol
  
  Volume: 86 Issue: 1 Pages: 185-194
- DOI
  10.1128/jvi.05245-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390116, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590554, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24659214
[Journal Article] TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
- Author(s)
  Shime H, M. Matsumoto, H. Oshiumi, S. Tanaka, A. Nakane, Y. Iwakura, H. Tahara, N. Inoue, and T. Seya
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Pages: 2066-2071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Toll-like receptor 3-mediated antivirus response is important for protection against poliovirus infection in poliovirus receptor transgenic mice2012
- Author(s)
  Abe, Y., K. Fujii, N. Nagata, O. Takeuchi, S. Akira, H. Oshiumi, M. Matsumoto, T. Seya, and S. Koike
- Journal Title
  
  J. Virol
  
  Volume: 86 Pages: 185-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The TLR3-TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection2011
- Author(s)
  Oshiumi, H., M. Okamoto, K. Fujii, T. Kawanishi, M. Matsumoto, S. Koike, and T. Seya
- Journal Title
  
  J. Immunol
  
  Volume: 187 Pages: 5320-5327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] The SKI2-related helicase DDX60 is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling2011
- Author(s)
  Miyashita, M., H. Oshiumi, M. Matsumoto, and T. Seya
- Journal Title
  
  Molec. Cell. Biol
  
  Volume: 31 Pages: 3802-3819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Antiviral responses induced by the TLR3 pathway. (review)2011
- Author(s)
  Matsumoto, M., H. Oshiumi, and T. Seya.
- Journal Title
  
  Rev. Med. Virol.
  
  Volume: 21 Issue: 2 Pages: 67-77
- DOI
  10.1002/rmv.680
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120
[Journal Article] Establishing mouse hepatoma cell lines permissive to human hepatitis C virus2011
- Author(s)
  Aly, H. H., H. Oshiumi, M. Matsumoto, K. Shimotohno, T. Wakita, and T. Seya
- Journal Title
  
  PLoS ONE
  
  Volume: 6 (6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Antiviral responses induced by the TLR3 pathway2011
- Author(s)
  Matsumoto, M., H. Oshiumi, and T. Seya
- Journal Title
  
  Rev. Med. Virol
  
  Volume: 21 Pages: 67-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with shizophrenia2011
- Author(s)
  Deng Xia, Takaki H, Wang Li, et.al.
- Journal Title
  
  American journal of Medical Genetics
  
  Volume: 156 Issue: 4 Pages: 850-858
- DOI
  10.1016/j.molimm.2010.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J01368, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120
[Journal Article] The TLR3-TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.2011
- Author(s)
  Oshiumi, H., M. Okamoto, K. Fujii, T. Kawanishi, M. Matsumoto, S. Koike, and T. Seya.
- Journal Title
  
  J. Immunol.
  
  Volume: 187 Issue: 10 Pages: 5320-5327
- DOI
  10.4049/jimmunol.1101503
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390116, KAKENHI-PROJECT-23390120
[Journal Article] Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV)2011
- Author(s)
  Aly, H.H., H.Oshiumi, H.Shime, M.Matsumoto, T.Wakita, K.Shimotohno, T.Seya
- Journal Title
  
  Plos ONE
  
  Volume: 6 Issue: 6 Pages: e21284-e21284
- DOI
  10.1371/journal.pone.0021284
- NAID
  120003169041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790371, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-23659407
[Journal Article] DDX60, a DHXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling2011
- Author(s)
  Miyashita, M., H.Oshiumi, M.Matsumoto, T.Seya
- Journal Title
  
  Mol.Cell Biol
  
  Volume: 31 Issue: 18 Pages: 3802-3819
- DOI
  10.1128/mcb.01368-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558
[Journal Article] DEAD BOX3(DDX3) helicases binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential2010
- Author(s)
  押海裕之
- Journal Title
  
  European Journal of Immunology
  
  Volume: 40 Pages: 940-948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790450
[Journal Article] DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential.2010
- Author(s)
  押海裕之以下3名省略
- Journal Title
  
  European Journal of Immunology 40巻
  
  Pages: 940-948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.2010
- Author(s)
  笹井美和、立松恵、押海裕之、以下4名省略
- Journal Title
  
  Molecular Immunology 47巻
  
  Pages: 1283-1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] DEAD/H BOX 3(DDX3)helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential2010
- Author(s)
  押海裕之
- Journal Title
  
  European Journal of Immunology (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction2010
- Author(s)
  押海裕之
- Journal Title
  
  Plos One
  
  Volume: 5
- NAID
  120002697703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790450
[Journal Article] The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune response to RNA virus infection2010
- Author(s)
  押海裕之
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 8 Pages: 496-509
- NAID
  120002725554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790450
[Journal Article] The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection2010
- Author(s)
  Oshiumi H, Miyashita M, Inoue N, Okabe M, Matsumoto M, Seya T
- Journal Title
  
  Cell Host Microbe
  
  Volume: 8 Issue: 6 Pages: 496-509
- DOI
  10.1016/j.chom.2010.11.008
- NAID
  120002725554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21687018, KAKENHI-PROJECT-22790450
[Journal Article] The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune response to RNA virus infection2010
- Author(s)
  押海裕之
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 8 Pages: 496-509
- NAID
  120002725554
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22117501
[Journal Article] Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction2010
- Author(s)
  押海裕之
- Journal Title
  
  Plos One
  
  Volume: 5
- NAID
  120002697703
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22117501
[Journal Article] DEAD BOX3(DDX3) helicases binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta inducing potential2010
- Author(s)
  押海裕之
- Journal Title
  
  European Journal of Immunology
  
  Volume: 40 Pages: 940-948
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22117501
[Journal Article] Riplet/RNA135, a RING Finger Protein, Ubiquitinates RIG-I to promote Interferon-b induction during the Early Phase of Viral Infection.2009
- Author(s)
  押海裕之、以下3名省略
- Journal Title
  
  JBC 284巻
  
  Pages: 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Regulator of Complement Activation (RCA) gene cluster in Xenopus tropicalis2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  Immunogenetics (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Pan-vertebrate Toll-like receptors during evolution(review)2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  Curr. Genomics 9
  
  Pages: 488-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Riplet/RNF135, a RING-finger protein, ubiquitinates RIG-I to promote interferon-β induction during the early phase of viral infection2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  J. Biol. Chem 284
  
  Pages: 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.2009
- Author(s)
  押海裕之, 他12名省略(13人中3番目)
- Journal Title
  
  Plos Genetics 6巻
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Riplet/RNA135, a RING Finger Protein, Ubiquitinates RIG-I to promote Interferon-β induction during the Early Phase of Viral Infection2009
- Author(s)
  Hiroyuki Oshiumi
- Journal Title
  
  Journal of Biological Chemisitry 284
  
  Pages: 807-817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Asp-Glu-Ala-Asp/His (DEAD/H) BOX 3 (DDX3) helicase assembles in the IFN-β promoter stimulator-1 (IPS-1) pathway to enhance IFN-β induction2009
- Author(s)
  Oshiumi, H., Seva, T. et.al.
- Journal Title
  
  PloS Pathol (submitted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041002
[Journal Article] Mitofusin 2 inhibits mitochondrial antiviral signaling.2009
- Author(s)
  安川開、押海裕之、以下6名省略
- Journal Title
  
  Science Signaling 2巻
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Regulator of complement activation (RCA) gene cluster in Xenopus tropicails.2009
- Author(s)
  押海裕之、以下3名省略
- Journal Title
  
  Immunogenetics 61巻
  
  Pages: 371-384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.2009
- Author(s)
  高木宏美、押海裕之以下4名省略
- Journal Title
  
  European Journal of Immunology 39巻
  
  Pages: 3469-3476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Regulator of complement activation (RCA)gene cluster in Xenopus tropi cails2008
- Author(s)
  Hiroyuki Oshiumi
- Journal Title
  
  Immunogenetics (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Journal Article] Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.2008
- Author(s)
  松尾綾、押海裕之、以下6名省略
- Journal Title
  
  Journal of Immunology 181巻
  
  Pages: 347-385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790364
[Patent] ワクチンの副反応リスクの検出方法2019
- Inventor(s)
  押海裕之
- Industrial Property Rights Holder
  押海裕之
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03480
[Patent] ワクチン接種後副反応を予測する検査方法2017
- Inventor(s)
  押海裕之
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-177767
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] Unusual type I interferons are associated with cholesterol metabolism and prime the antiviral innate immune response2023
- Author(s)
  Hiroyuki Oshiumi
- Organizer
  第87回　日本インターフェロン・サイトカイン学会学術集会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27640
[Presentation] ウイルス感染に対する自然免疫応答とコレステロール2023
- Author(s)
  押海裕之
- Organizer
  日本肺サーファクタント・界面医学会第59回学術研究集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27640
[Presentation] 細胞外小胞内microRNAとワクチン接種後の免疫応答2021
- Author(s)
  押海裕之
- Organizer
  阿蘇シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H03480
[Presentation] 細胞内ウイルスRNAセンサーの翻訳後修飾による自然免疫応答の制御2021
- Author(s)
  押海裕之
- Organizer
  日本生体防御学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03480
[Presentation] Innate immune response against SARS-CoV-22021
- Author(s)
  押海　裕之
- Organizer
  第98回　日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03480
[Presentation] ワクチンの副反応を予測する方法と新型コロナウイルスに対するペプチドワクチンの開発2021
- Author(s)
  押海　裕之、中嶋桃香、入江　厚
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03480
[Presentation] 新型コロナウイルスに対する自然免疫と獲得免疫2021
- Author(s)
  押海裕之
- Organizer
  第50回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03480
[Presentation] ZNF598 delivers a ubiquitin-like modifier FAT10 to RIG-I and attenuates the innate immune response against viral infection2019
- Author(s)
  Wang Guanming, Takahisa Kouwaki, Hiroyuki Oshiumi
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-19H03480
[Presentation] 血中細胞外小胞内の免疫性御性microRNAとワクチン接種後の過剰な免疫応答2019
- Author(s)
  押海裕之
- Organizer
  日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-19H03480
[Presentation] インフルエンザ全粒子ワクチンに対する自然免疫応答での細胞外小胞の役割2017
- Author(s)
  押海裕之
- Organizer
  日本生体防御学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] 細胞外小胞による細胞間情報伝達における補体の役割2017
- Author(s)
  押海裕之、岡本将明、福島好
- Organizer
  日本補体学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] B型肝炎ウイルスに対する自然免疫応答におけるエクソソームの役割2016
- Author(s)
  押海裕之
- Organizer
  第８１回日本インターフェロンサイトカイン学会学術集会
- Place of Presentation
  長崎大学（長崎）
- Invited
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] Extracellular Vesicles Including Exosomes Regulates Innate Immune Responses to Hepatitis B Virus Infection2016
- Author(s)
  Hiroyuki Oshiumi, Takahisa Kouwaki, Yoshimi Fukushima, Masaaki Okamoto
- Organizer
  第１５回あわじしま感染症・免疫フォーラム
- Place of Presentation
  淡路夢舞台国際会議場（兵庫）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] DDX60, a cytoplasmic RNA helicase, enhances RIG-I-dependent and –independent antiviral innate immune response2015
- Author(s)
  Hiroyuki Oshiumi
- Organizer
  日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08517
[Presentation] Hepatitis C virus degrades Riplet ubiquitin ligase to escape host innate immune response2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  International congress of immunology 2013
- Place of Presentation
  Milano Congressi ミラノ（イタリア）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] Hepatitis C virus NS3-4A protease cleaves Riplet ubiquitin ligase to abrogate RIG-I-mediated type I interferon production2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] Hepatitis C virus NS3-4A protease cleaves Riplet ubiquitin ligase to abrogate RIG-I-mediated type I interferon production2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] Hepatitis C virus degrades Riplet ubiquitin ligase to escape host innate immune response2013
- Author(s)
  Oshiumi H, Matsumoto M, Seya T
- Organizer
  International congress of immunology 2013
- Place of Presentation
  Milano Congressi ミラノ（イタリア）
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] ウイルスによる自然免疫活性化とその抑制機構2012
- Author(s)
  押海裕之
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(札幌市)(招待講演)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] Riplet ubiquitin ligase plays essential role in RIG-I-mediated type I interferon productioin, and is targeted by hepatitis C virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場（兵庫）
- Year and Date
  2012-12-05
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] Riplet ubiquitin ligase is essential for TRIM25-mediated RIG-I activation and is targeted by hepatitis c virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  IEIIS2012 Homeostatic Inflammation Symposium
- Place of Presentation
  学術総合センター（東京）
- Year and Date
  2012-10-23
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] C型肝炎ウイルスが、Ripletユビキチンライゲースを分解しRIG-I依存的なI型インターフェロン産生を抑制するメカニズムの解明2012
- Author(s)
  押海裕之　松本美佐子　瀬谷司
- Organizer
  日本ウイルス学会
- Place of Presentation
  グランキューブ大阪（大阪）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] C型肝炎ウイルスが、Ripletユビキチンライゲースを分解しRIG-I依存的なI型インターフェロン産生を抑制するメカニズムの解明2012
- Author(s)
  押海裕之　松本美佐子　瀬谷司
- Organizer
  日本ウイルス学会
- Place of Presentation
  グランキューブ大阪（大阪）
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PUBLICLY-24117702
[Presentation] Riplet ubiquitin ligase plays essential role in RIG-I-mediated type I interferon production, and is targeted by hepatitis C virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場（兵庫）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] Riplet ubiquitin ligase is essential for TRIM25-mediated RIG-I activation and is targeted by Hepatitis C virus2012
- Author(s)
  Oshiumi H. Matsumoto M. Seya T.
- Organizer
  IEIIS2012 Homeostatic Inflammation Symposium
- Place of Presentation
  学術総合センター（東京）
- Data Source
  KAKENHI-PROJECT-24590570
[Presentation] ウイルスによる自然免疫活性化とその抑制機構2012
- Author(s)
  押海裕之
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(札幌市)(招待講演)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] ウイルスによる自然免疫活性化とその抑制機構2012
- Author(s)
  押海裕之
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] Regulatory mechanism of RIG-I by Riplet ubiquitin ligase2011
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉県)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] Regulatory mechanism of RIG-I by Riplet ubiquitin ligase2011
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] The ubiquitin ligase Riplet is essential for RIG-I dependent type I interferon production in response to RNA virus infection2011
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  バシフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] The ubjquitin ligase Riplet is essential for RIG-I dependent type I interferon production in response to RNA virus infection2011
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  バシフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] Riplet ubiquitin ligase is essential for RIG-I dependent type I interferon production2011
- Author(s)
  押海裕之
- Organizer
  Keystone Symposium
- Place of Presentation
  Santa Fe Community Convention center(アメリカ合衆国)
- Year and Date
  2011-02-15
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] Regulatory mechanism of RIG-I by Riplet ubiquitin ligase2011
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉県)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] The ubiquitin ligase Riplet is essential for RIG-I dependent type I interferon production in responses to RNA virus infection2011
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  バシフィコ横浜(神奈川)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] Riplet ubiquitin ligase is essential for RIG-I dependent type I interferon production2011
- Author(s)
  押海裕之
- Organizer
  Keystone Symposium
- Place of Presentation
  Santa Fe Community Convention center (アメリカ合衆国)
- Year and Date
  2011-02-15
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] TICAM-1/TRIF, a TLR3 adaptor, is essential for protection against poliovirus infection.2010
- Author(s)
  押海裕之
- Organizer
  国際免疫学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] TICAM-1/TRIF, a TLR3 adaptor, is essential for protection against poliovirus infection.2010
- Author(s)
  押海裕之
- Organizer
  国際免疫学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] 細胞質内ウイルスRNA認識センサーRIG-Iをユビキチン化するRiplet分子のノックアウトマウス作成と機能解析2010
- Author(s)
  押海裕之
- Organizer
  インターフェロンサイトカイン学会
- Place of Presentation
  北九州国際会議場(福岡県)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-22790450
[Presentation] 細胞質内ウイルスRNA認識センサーRIG-Iをユビキチン化するRiplet分子のノックアウトマウス作成と機能解析2010
- Author(s)
  押海裕之
- Organizer
  インターフェロンサイトカイン学会
- Place of Presentation
  北九州国際会議場(福岡県)
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PUBLICLY-22117501
[Presentation] ウイルス感染時のRIG-I分子を介したDDX3ヘリケースによるI型インターフェロン産生シグナルの促進機構とC型肝炎ウイルスコア蛋白質による抑制機構の解明2009
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  神奈川県
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] DDX3 RNA helicase associates with RIG-1 and IPS-1, and Hepatitis C virus core protein blocks the interaction of DDX3 with IPS-1 to suppress the type I interferon production2009
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] DDX3 RNA helicase associates with RIG-I and IPS-1, and Hepatitis C virus core protein blocks the interaction of DDX3 with IPS-1 to suppress the type I interferon production2009
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  大阪府
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] ウイルス感染時のRIG-I分子を介したDDX3ヘリケースによるI型インターフェロン産生シグナルの促進機構とC型肝炎ウイルスコア蛋白質による抑制機構の解明2009
- Author(s)
  押海裕之
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜国際会議場(神奈川県)
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] RNAヘリケースのDDX3はウイルス感染時のIPS-1分子に依存したI型インターフェロン産生に関与する2008
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  京都国立京都国際会館
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] Riplet: a novel RING finger protein that activates RIG-I2008
- Author(s)
  Hiroyuki Oshiumi et. al.
- Organizer
  Keystone symposium
- Place of Presentation
  Keyston Resort, Colorado USA
- Year and Date
  2008-02-26
- Data Source
  KAKENHI-PROJECT-18770152
[Presentation] RNAヘリケースのDDX3はウイルス感染時のIPS-1分子に依存したI型インターフェロン産生に関与する2008
- Author(s)
  押海裕之
- Organizer
  日本免疫学会
- Place of Presentation
  京都府
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20790364
[Presentation] ユビキチンによるウイルスRNA認識センサー RIG-Iの活性化制御機構
- Author(s)
  押海裕之
- Organizer
  第25回日本生体防御学会学術総会
- Place of Presentation
  東北大学　片平さくらホール　（仙台）
- Year and Date
  2014-07-09 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-24590570

1. SEYA Tsukasa (10301805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
2. MATSUMOTO Misako (30332456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
3. SHIME Hiroaki (70372133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 海老原敬 (20374407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AWAI Hirotake

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SUZUKI Tadaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 幸脇貴久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 魏范研

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 小原道法

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 西村康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 安田忠仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 石本崇胤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 井上直和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 茶山一彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 高島謙

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 岡部勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 藤倉大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 笠原正典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshiumi Hiroyuki 押海 裕之

OSHIUMI Hiroyuki 押海 裕之

Research Projects

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Co-Researchers

ワクチン接種後の免疫応答の個人差を決める重要な要因としてのエクソソームPrincipal Investigator

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代謝異常がウイルスに対する自然免疫を制御する新たなメカニズムの解明Principal Investigator

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Study of innate immune responses against viral infectionPrincipal Investigator

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Novel interaction between virus and host innate immune systemPrincipal Investigator

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自然免疫系の細胞質内核酸認識経路が自然炎症を引き起こす仕組みPrincipal Investigator

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Novel molecular mechanisms of antiviral innate immune responsePrincipal Investigator

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Molecular mechanisms of dendritic cell maturation in response to pattern sensing

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自然免疫に於ける未知の微生物認識分子群の単離と炎症への繋がりの解明Principal Investigator

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In vivo role of novel innate immune factors during viral infectionPrincipal Investigator

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Isolation and analysis of novel molecules that recognize viral infectionPrincipal Investigator

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ウイルス感染のRNA応答

Principal Investigator

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限られた時間内に相同組換えが終わる仕組みと、組換えの新たな展開Principal Investigator

Principal Investigator

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サイクリンが遺伝的組換えを制御し癌を抑制する仕組みPrincipal Investigator

Principal Investigator

Project Period (FY)

Oshiumi Hiroyuki 押海裕之

OSHIUMI Hiroyuki 押海裕之