KINOSHITA Naoe 木下直江

Researcher Number	50380928
Affiliation (based on the past Project Information) *help	2017: 長崎大学, 病院(医学系), 助教 2014: 長崎大学, 病院(医学系), 助教 2012 – 2013: 長崎大学, 大学病院, 助教
Review Section/Research Field	Except Principal Investigator Orthopaedic surgery / Human genetics
Keywords	Except Principal Investigator CRISPR/Cas9法 / カムラチ・エンゲルマン病( / 骨系統疾患 / 患者iPS細胞 / カムラチ・エンゲルマン病 / ゲノム編集 / iPS細胞 / TGF-β1 / カムラチ-エンゲルマン病 / ユビキチン化 … More / 炎症 / IL-6 / 細胞ストレス / ユビキチン化タンパク質 / 中条-西村症候群 / ノックインマウス / β5iサブユニット / 中條－西村症候群 / 次世代型シーケンサー / ジーンターゲッティング / PSMB8 / 中條-西村症候群 / 自己炎症性疾患 / プロテアソーム Less

Development of new treatments for bone dysplasia caused by a mutation in TGFB1 utilizing patient-derived iPS cells
- Principal Investigator
  
  KINOSHITA Akira
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University
Proteasome dysfunction and autoinflammatory diseases: A novel pathogenic mechanism caused by cell stress.
- Principal Investigator
  
  KINOSHITA Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Nagasaki University

All 2018 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm.2018
- Author(s)
  Sato S, Itonaga H, Taguchi M, Sawayama Y, Imanishi D, Tsushima H, Hata T, Moriuchi Y, Mishima H, Kinoshita A, Yoshiura KI, Miyazaki Y.
- Journal Title
  
  Int J Hematol.
  
  Volume: - Issue: 2 Pages: 213-217
- DOI
  10.1007/s12185-018-2419-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-17K16189, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-17H04209
[Journal Article] Detection of de novo single nucleotide variants in offspring of atomic-bomb survivors close to the hypocenter by whole-genome sequencing.2018
- Author(s)
  Horai M, Mishima H, Hayashida C, Kinoshita A, Nakane Y, Matsuo T, Tsuruda K, Yanagihara K, Sato S, Imanishi D, Imaizumi Y, Hata T, Miyazaki Y, Yoshiura KI.
- Journal Title
  
  J Hum Genet.
  
  Volume: 63 Issue: 3 Pages: 357-363
- DOI
  10.1038/s10038-017-0392-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-15K10481, KAKENHI-ORGANIZER-18H05505, KAKENHI-PLANNED-18H05506
[Journal Article] Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl Psychiatry.2018
- Author(s)
  Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S.
- Journal Title
  
  Transl Psychiatry
  
  Volume: 8 Issue: 1 Pages: 41-41
- DOI
  10.1038/s41398-017-0088-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-26461721, KAKENHI-PROJECT-17K10276, KAKENHI-PROJECT-17K10309, KAKENHI-PROJECT-16K10190, KAKENHI-PROJECT-16K10193
[Journal Article] Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease.2017
- Author(s)
  Morimoto Y, Ono S, Imamura A, Okazaki Y, Kinoshita A, Mishima H, Nakane H, Ozawa H, Yoshiura KI, Kurotaki N.
- Journal Title
  
  Hum Genome Var.
  
  Volume: 4 Issue: 1 Pages: 17032-17032
- DOI
  10.1038/hgv.2017.32
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-17K10276, KAKENHI-PROJECT-17K10309, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-26461721, KAKENHI-PROJECT-16K10190
[Journal Article] Generation and characterization of a conditional allele of Interferon Regulatory Factor 6.2017
- Author(s)
  Smith AL, Kousa YA, Kinoshita A, Fodor K, Yang B, Schutte BC.
- Journal Title
  
  Genesis.
  
  Volume: 55 Issue: 7
- DOI
  10.1002/dvg.23038
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10481
[Journal Article] Expression of Somatostatin Receptor Type 2A and PTEN in Neuroendocrine Neoplasms Is Associated with Tumor Grade but Not with Site of Origin.2016
- Author(s)
  Wada H, Matsuda K, Akazawa Y, Yamaguchi Y, Miura S, Ueki N, Kinoshita A, Yoshiura K, Kondo H, Ito M, Nagayasu T, Nakashima M.
- Journal Title
  
  Endocr Pathol.
  
  Volume: 27(3) Issue: 3 Pages: 179-187
- DOI
  10.1007/s12022-016-9436-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-15K08379, KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-16K08702
[Journal Article] Ultra-sensitive droplet digital PCR for detecting a low-prevalence somatic GNAQ mutation in Sturge-Weber syndrome.2016
- Author(s)
  Uchiyama Y, Nakashima M, Watanabe S, Miyajima M, Taguri M, Miyatake S, Miyake N, Saitsu H, Mishima H, Kinoshita A, Arai H, Yoshiura K, Matsumoto N.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 22985-22985
- DOI
  10.1038/srep22985
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-25430183, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118007, KAKENHI-PROJECT-16H05357
[Journal Article] Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature.2016
- Author(s)
  Matsuda K, Tateishi S, Akazawa Y, Kinoshita A, Yoshida S, Morisaki S, Fukushima A, Matsuwaki T, Yoshiura KI, Nakashima M.
- Journal Title
  
  Diagn Pathol.
  
  Volume: 11(1) Issue: 1 Pages: 101-101
- DOI
  10.1186/s13000-016-0554-7
- NAID
  120006987629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-15K10481
[Journal Article] カムラチ・エンゲルマン病2015
- Author(s)
  木下　晃
- Journal Title
  
  日本臨床
  
  Volume: 73 Pages: 2149-2159
- Data Source
  KAKENHI-PROJECT-15K10481
[Journal Article] Germline mutations causing familial lung cancer.2015
- Author(s)
  Tomoshige K, Matsumoto K, Tsuchiya T, Oikawa M, Miyazaki T, Yamasaki N, Mishima H, Kinoshita A, Kubo T, Fukushima K, Yoshiura K, Nagayasu T.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 60 Issue: 10 Pages: 597-603
- DOI
  10.1038/jhg.2015.75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10481, KAKENHI-PROJECT-25430183, KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-25293084
[Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome2014
- Author(s)
  Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura KI, Masuzaki H.
- Journal Title
  
  Prenatal Diagnosis
  
  Volume: 34 Issue: 4 Pages: 345-349
- DOI
  10.1002/pd.4307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592406, KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-24791712, KAKENHI-PROJECT-25293084, KAKENHI-PROJECT-25430183, KAKENHI-PROJECT-25462563, KAKENHI-PROJECT-26462495
[Journal Article] Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US.2014
- Author(s)
  Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Yoshida A, Kaneuchi M, Yoshiura K, Masuzaki H.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 59 (5) Issue: 5 Pages: 251-255
- DOI
  10.1038/jhg.2014.9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-24791711, KAKENHI-PROJECT-25293084, KAKENHI-PROJECT-25430183, KAKENHI-PROJECT-25861498, KAKENHI-PROJECT-26462495
[Journal Article] Identification of endometrioid endometrial carcinoma-associated microRNAs in tissue and plasma.2014
- Author(s)
  Tsukamoto O, Miura K, Mishima H, Abe S, Kaneuchi M, Higashijima A, Miura S, Kinoshita A, Yoshiura K, Masuzaki H.
- Journal Title
  
  Gynecologic Oncology
  
  Volume: 132 (3) Issue: 3 Pages: 715-721
- DOI
  10.1016/j.ygyno.2014.01.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-25293084, KAKENHI-PROJECT-25430183, KAKENHI-PROJECT-25462563, KAKENHI-PROJECT-25861498, KAKENHI-PROJECT-26462495
[Journal Article] Genome-wide association study of HPV-associated cervical cancer in Japanese women.2014
- Author(s)
  Miura K, Mishima H, Kinoshita A, Hayashida C, Abe S, Tokunaga K, Masuzaki H, Yoshiura KI.
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 86 (7) Issue: 7 Pages: 1153-1158
- DOI
  10.1002/jmv.23943
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-25293084, KAKENHI-PROJECT-25430183, KAKENHI-PROJECT-25462563, KAKENHI-PROJECT-25550033, KAKENHI-PROJECT-26462495, KAKENHI-PROJECT-221S0002
[Journal Article] Initial viral load in cases of single human papillomavirus 16 or 52 persistent infection is associated with progression of later cytopathological findings in the uterine cervix2013
- Author(s)
  Hamaguchi D, Miura K, Abe S, Kinoshita A, Miura S, Yamasaki K, Yoshiura K, Masuzaki H
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 85 Issue: 12 Pages: 2093-2100
- DOI
  10.1002/jmv.23709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592406, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-24791711, KAKENHI-PROJECT-24791712, KAKENHI-PROJECT-25462563, KAKENHI-PROJECT-25550033
[Journal Article] Characterization of placenta-specific microRNAs in fetal growth restriction pregnancy2013
- Author(s)
  Higashijima A
- Journal Title
  
  Prenat Diagn
  
  Volume: 33 Issue: 3 Pages: 214-222
- DOI
  10.1002/pd.4045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591827, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-24791711, KAKENHI-PROJECT-25462563
[Journal Article] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer.2013
- Author(s)
  Abe, S, Miura, K, Kinoshita, A, Mishima, H, Miura, S, Yamasaki, K, Hasegawa, Y, Higashijima, A, Jo, O, Sasaki, K, Yoshida, A, Yoshiura, KI, Masuzaki.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 58 Issue: 5 Pages: 250-253
- DOI
  10.1038/jhg.2013.7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J11173, KAKENHI-PROJECT-22591827, KAKENHI-PROJECT-23592406, KAKENHI-PROJECT-23791230, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-24791711, KAKENHI-PROJECT-24791712, KAKENHI-PROJECT-25293084, KAKENHI-PROJECT-25462563
[Journal Article] The role of Irf6 in tooth epithelial invagination.2012
- Author(s)
  Blackburn J, Ohazama A, Kawasaki K, Otsuka-Tanaka Y, Liu B, Honda K, Rountree R, Hu Y, Kawasaki M, Birchmeier W, Schmidt-Ullrich R, Kinoshita A, Schutte B, Hammond N, Dixon M, Sharpe P.
- Journal Title
  
  Developmental Biology
  
  Volume: 365 Issue: 1 Pages: 61-70
- DOI
  10.1016/j.ydbio.2012.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590403
[Journal Article] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair2012
- Author(s)
  Nakazawa Y, Sasaki K, Mitsutake N, Yamashita S, Ogi T, et al
- Journal Title
  
  Nat Genet
  
  Volume: 44(5) Issue: 5 Pages: 586-92
- DOI
  10.1038/ng.2229
- NAID
  120006985586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390189, KAKENHI-PROJECT-22710056, KAKENHI-PROJECT-22791204, KAKENHI-PROJECT-23510065, KAKENHI-PROJECT-23590355, KAKENHI-PROJECT-24300328, KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-24659533, KAKENHI-PROJECT-24681008, KAKENHI-PROJECT-24790321
[Journal Article] Mutations in PRRT2 responsible for paroxysmal kinesigenic dyskinesias also cause benign familialinfantile convulsions.2012
- Author(s)
  Ono S, Yoshiura K , KinoshitaA, Kikuchi T, Nakane Y, Kato N,Sadamatsu M , Konishi T , Nagamitsu S , Matsuura M, Yasuda A, KomineM, Kanai K , Inoue T , Osamura T , Saito K , Hirose S, Koide H, Tomita H , Ozawa H , Niikawa N and Kurotaki N.
- Journal Title
  
  J Hum Genet
  
  Volume: 57 Issue: 5 Pages: 1-4
- DOI
  10.1038/jhg.2012.23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249062, KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-22390066, KAKENHI-PROJECT-23659529, KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24590403, KAKENHI-PROJECT-24659535, KAKENHI-PROJECT-22591263, KAKENHI-PLANNED-22132004, KAKENHI-PLANNED-24116007
[Journal Article] No evidence of association between 8q24 and susceptibility to nonsyndromic cleft lip with or without palate in Japanese population2011
- Author(s)
  Hikida M, Tsuda M, Watanabe A
- Journal Title
  
  Cleft Palate Craniofac J
  
  Volume: (掲截確定) Issue: 6 Pages: 714-717
- DOI
  10.1597/10-242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792018, KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-24590403
[Presentation] Mutations in the patients with NNS-like autoinflammatory diseases2016
- Author(s)
  Akira Kinoshita
- Organizer
  The 13th International Congress of Human Genetics
- Place of Presentation
  Kyoto International Conference Center (京都府・京都市）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10481
[Presentation] Mutations in the patients with NNS-like autoinflammatory diseases2016
- Author(s)
  Akira Kinoshita
- Organizer
  International Congress of Human Genetics
- Place of Presentation
  国立京都国際会（京都府・京都市）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10481
[Presentation] 中條-西村症候群様自己炎症性疾患の変異解析2015
- Author(s)
  木下　晃
- Organizer
  第６０回日本人類遺伝学会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K10481

1. KINOSHITA Akira (60372778)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. YOSHIURA Koh-Ichiro (00304931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. MIURA Kiyonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 渡邊章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 光武範吏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山下俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 廣瀬伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 齋藤亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 井上隆司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KINOSHITA Naoe 木下 直江

Research Projects

Research Products

Co-Researchers

Development of new treatments for bone dysplasia caused by a mutation in TGFB1 utilizing patient-derived iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteasome dysfunction and autoinflammatory diseases: A novel pathogenic mechanism caused by cell stress.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clonal dynamics in a case of acute monoblastic leukemia that later developed myeloproliferative neoplasm.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of de novo single nucleotide variants in offspring of atomic-bomb survivors close to the hypocenter by whole-genome sequencing.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl Psychiatry.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation and characterization of a conditional allele of Interferon Regulatory Factor 6.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of Somatostatin Receptor Type 2A and PTEN in Neuroendocrine Neoplasms Is Associated with Tumor Grade but Not with Site of Origin.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ultra-sensitive droplet digital PCR for detecting a low-prevalence somatic GNAQ mutation in Sturge-Weber syndrome.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid growth of mitotically active cellular fibroma of the ovary: a case report and review of the literature.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] カムラチ・エンゲルマン病2015

Author(s)

Journal Title

Data Source

[Journal Article] Germline mutations causing familial lung cancer.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of endometrioid endometrial carcinoma-associated microRNAs in tissue and plasma.2014

Author(s)

Journal Title

DOI

KINOSHITA Naoe 木下直江