Yamaguchi Kanji 山口寛二

… Alternative Names

YAMAGUCHI KANJI 山口寛二

YAMAGUCHI Kanji 山口寛二

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Researcher Number	50381950
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2025: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2022 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2020 – 2021: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2013 – 2019: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2010: Kyoto Prefectural University of Medicine, 医学研究科, 助教(寄附講座) … More 2010: 京都府立医科大学, 医学部, 助教(寄付講座) 2008 – 2010: 京都府立医科大学, 医学部付属病院, 研究員 2009: Kyoto Prefectural University of Medicine, 医学部, 助教(寄附講座) 2008: Kyoto Prefectural University of Medicine, 医学部・附属病院, 専攻医 Less
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 脂肪肝炎 / 分子シャペロン / Apg-2 / 肝がん / 脂肪肝 / 肝細胞癌 / バイオマーカー / オルガノイド / mTOR / 熱ショック蛋白 … More / リポファジー / 蛋白質 / 内科 / 肝癌 / ユビキチン化 / HSP110 / LKB1 / 免疫老化 / 獲得免疫 / PD-1 / 肝発癌 / 肝線維化 / 肝脂肪化 / 炎症 / DGAT … More Except Principal Investigator 分子シャペロン / Apg-2 / 非アルコール性脂肪肝炎 / バイオマーカー / 脂肪肝 / ELISA / 脂肪肝炎 / ユビキチン化 / 細胞周期 / 肝癌 / 脂肪性肝炎 / アルコール性肝炎 / 非アルコール肝炎(NASH) / マウスアルコール肝炎(ASH) / 線維化 / アポトーシス / c-Met / Sp1 / 非アルコール脂肪性肝炎 / 小胞体ストレス / 架橋反応 / トランスグルタミナーゼ / アルコール脂肪性肝炎 / Sp1, c-Met,アポトーシス Less

The development of steatohepatitis treatment via chaperone-associated ubiquitination by the heat shock protein Apg-2.Principal Investigator
- Principal Investigator
  
  山口寛二
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
The role of heat shock protein Apg-2 in hepatic lipogenesis and hepatocarcinogenesis by using liver organoids.Principal Investigator
- Principal Investigator
  
  山口寛二
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Significance of Apg-2 in human NAFLD
- Principal Investigator
  
  伊藤義人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
The role of heat shock protein Apg-2 in hepatic lipogenesis and hepatocarcinogenesis by the inhibition of lipophagyPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Kanji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
The role of HSP110 family, Apg-2 in NASH-related hepatic lipid and glucose metabolism.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI KANJI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
The role of Apg-2 in liver steatosis and carcinogenesis
- Principal Investigator
  
  Itoh Yoshito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
Examination about the association between intrahepatic immunogenicity and the expression of regulatory molecules on hepatic T cells in mouse NASH model.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI KANJI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
Studies on a role of a crosslinking enzyme, transglutaminase in pathogenesis of liver diseases
- Principal Investigator
  
  KOJIMA Soichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  The Institute of Physical and Chemical Research
The effect of DGAT on liver steatosis, fibrosis and carcinogenesis in murine NASH models.Principal Investigator
- Principal Investigator
  
  YAMAGUCHI Kanji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2010 2009 2008

All Journal Article Presentation Book

[Book] 肝胆膵 NASH/NAFLDの臨床の進歩と問題点オベチコール酸（DSP-1747）によるNASH治療2018
- Author(s)
  山口寛二, 瀬古裕也, 楳村敦詩, 西川太一朗, 森口理久, 伊藤義人
- Total Pages
  7
- Publisher
  アークメディア
- Data Source
  KAKENHI-PROJECT-16K09368
[Book] ＮＡＳＨにおける肝癌発生の実態2018
- Author(s)
  伊藤義人, 山口寛二, 楳村敦詩, 森口理久, 原祐, 瀬古裕也
- Total Pages
  7
- Publisher
  臨床消化器内科
- Data Source
  KAKENHI-PROJECT-16K09368
[Journal Article] Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice.2022
- Author(s)
  Yano K, Yamaguchi K, Seko Y, Okishio S, Ishiba H, Tochiki N, Takahashi A, Kataoka S, Okuda K, Liu Y, Fujii H, Umemura A, Moriguchi M, Okanoue T, Itoh Y.
- Journal Title
  
  Lab Invest.
  
  Volume: 102(3) Issue: 3 Pages: 281-289
- DOI
  10.1038/s41374-021-00680-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08038
[Journal Article] PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat2020
- Author(s)
  Okishio Shinya、Yamaguchi Kanji、Ishiba Hiroshi、Tochiki Nozomi、Yano Kota、Takahashi Aya、Kataoka Seita、Okuda Keiichiroh、Seko Yuya、Liu Yu、Fujii Hideki、Takahashi Daiki、Ito Yusuke、Kamon Junji、Umemura Atsushi、Moriguchi Michihisa、Yasui Kohichiroh、Okanoue Takeshi、Itoh Yoshito
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 19578-19578
- DOI
  10.1038/s41598-020-75805-z
- Data Source
  KAKENHI-PROJECT-19K08473
[Journal Article] Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.2010
- Author(s)
  Yamaguchi K, Itoh Y, Yokomizo C, Nishimura T, Niimi T, Fujii H, Okanoue T, Yoshikawa T.
- Journal Title
  
  Lab Invest. 90(8)
  
  Pages: 1169-1178
- Data Source
  KAKENHI-PROJECT-20790503
[Journal Article] Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.2010
- Author(s)
  Yamaguchi Kanji, et al.
- Journal Title
  
  Laboratory investigation
  
  Volume: Aug;90(8) Pages: 1169-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790503
[Presentation] Hepatocyte-specific Growth Differentiation Factor 15 overexpression ameliorates high-fat diet-induced obesity and liver steatosis via induction on Fibroblast Growth Factor 21 in mice.2023
- Author(s)
  Takeuchi K, Yamaguchi K, Takahashi Y, Yano K, Kataoka S, Seko Y, Moriguchi M, Itoh Y.
- Organizer
  AASLD 2023 THE Liver Meeting
- Data Source
  KAKENHI-PROJECT-22K08038
[Presentation] マウスNAFLDにおけるミトカインGDF15の役割.2023
- Author(s)
  竹内健人, 山口寛二, 高橋佑輔, 矢野航太, 片岡星太, 瀬古裕也, 森口理久, 伊藤義人.
- Organizer
  第59回日本肝臓学会総会.
- Data Source
  KAKENHI-PROJECT-22K08038
[Presentation] 20.FGF21-FGFR1/β-klotho 経路を介した非アルコール性脂肪性肝疾患（NAFLD）の治療戦略.2022
- Author(s)
  山口寛二, 瀬古裕也, 伊藤義人
- Organizer
  第58回日本肝臓学会総会. パネルディスカッション
- Data Source
  KAKENHI-PROJECT-22K08038
[Presentation] 21.FGF21を介した肝におけるインスリン抵抗性改善作用の検討.2022
- Author(s)
  山口寛二, 矢野航太, 瀬古裕也, 伊藤義人
- Organizer
  第8回肝臓と糖尿病・代謝研究会. ワークショップ 2
- Data Source
  KAKENHI-PROJECT-22K08038
[Presentation] 進行マウス NASH モデルにおける FGF21 の発現意義の検討2021
- Author(s)
  矢野航太、山口寛二、伊藤義人
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08473
[Presentation] 肥満脂肪肝マウスモデルにおけるFGF21の肝特異的発現の検討2021
- Author(s)
  矢野航太、山口寛二、伊藤義人
- Organizer
  第11回肥満と消化器疾患研究会
- Data Source
  KAKENHI-PROJECT-19K08473
[Presentation] Metformin および PPARα agonist の併用による NASH 治療の検討2020
- Author(s)
  置塩伸也、山口寛二、伊藤義人ら
- Organizer
  第 56 回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K08473
[Presentation] The relationship between the PNPLA3, TLL1 polymorphism combination and advanced fibrosis in Japanese patients with non-alcoholic fatty liver disease.2019
- Author(s)
  瀬古裕也、山口寛二、楳村敦詩、伊藤義人
- Organizer
  EASL The International Liver Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09368
[Presentation] Apg-2による肝脂肪化及びmTORシグナルを介した肝発がん機序の解析2019
- Author(s)
  山口寛二, 石破博, 伊藤義人
- Organizer
  第55回肝臓学会総会.　パネルディスカッション
- Data Source
  KAKENHI-PROJECT-19K08473
[Presentation] 分子メカニズムと最新の治療. 分子シャペロンApg-2 が制御する脂肪肝形式と肝発がん機序の検討2019
- Author(s)
  山口寛二, 石破博, 伊藤義人
- Organizer
  第6回肝臓と糖尿病・代謝研究会　シンポジウム
- Data Source
  KAKENHI-PROJECT-19K08473
[Presentation] メタボリックシンドロームとしての脂肪肝. 分子シャペロンAPG-2による肥満及び脂肪肝発症機序の解析2019
- Author(s)
  山口寛二, 石破博, 伊藤義人
- Organizer
  第105回日本消化器病学会総会　パネルディスカッション
- Data Source
  KAKENHI-PROJECT-19K08473
[Presentation] 分子シャペロンAPG-2を標的にしたNAFLD治療戦略2018
- Author(s)
  山口寛二, 石破博, 伊藤義人
- Organizer
  第54回日本肝臓病学会総会
- Data Source
  KAKENHI-PROJECT-16K09368
[Presentation] Apg-2 plays an important role in hepatic steatosis2017
- Author(s)
  Yamaguchi Kanji, Ishiba Hiroshi, Seko Yuya, Umemura Atsushi, Itoh Yoshito
- Organizer
  第1回ICFL The 1st International Conference on Fatty Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09368
[Presentation] 分子シャペロンApg-2をターゲットにした肝脂肪化治療戦略2017
- Author(s)
  山口寛二、石破博、伊藤義人
- Organizer
  第53回日本肝臓学会総会（広島）、PD2-14（追加発言）
- Data Source
  KAKENHI-PROJECT-15K09018
[Presentation] 分子シャペロンApg-2をターゲットにした肝脂肪化治療戦略2017
- Author(s)
  山口寛二、石破博、伊藤義人
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09368
[Presentation] Apg-2 plays an important role in hepatic steatosis2017
- Author(s)
  Yamaguchi Kanji, Ishiba Hiroshi, Seko Yuya, Umemura Atsushi, Itoh Yoshito
- Organizer
  第1回ICFL The 1st International Conference on Fatty Liver
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09018
[Presentation] Heat shock protein 110ファミリー・Apg-2の脂肪肝形成における役割2016
- Author(s)
  山口寛二、石破　博、伊藤義人
- Organizer
  第52回　日本肝臓学会総会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-16K09368
[Presentation] Apg2 is a key determinant of hepatic steatosis by regulating AMPK activity2016
- Author(s)
  Hiroshi Ishiba, Kanji Yamaguchi, Itoh Yoshito
- Organizer
  The Liver Meeting® 2016 第67回米国肝臓学会
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-15K09018
[Presentation] Apg-2 is a key determinant of hepatic steatosis by regulating AMPK activity.2016
- Author(s)
  Hiroshi Ishiba, Kanji Yamaguchi, Yoshito Itoh
- Organizer
  The Liver Meeting 2016.
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-16K09368
[Presentation] Two different aspects of PD-1 expression on intrahepatic CD4+ and CD8+ T cells in a High Fat High Cholesterol Diet-induced murine NASH.2015
- Author(s)
  Kanji Yamaguchi, Akira Okajima, Yuya Seko, Hiroshi Ishiba, Hiroyoshi Taketani, Atsushi Umemura, Taichiro Nishikawa, Yoshio Sumida, Hironori Mitsuyoshi, Kohichiroh Yasui, Takeshi Okanoue, Yoshito Itoh.
- Organizer
  第66回AASLD
- Place of Presentation
  San Francisco
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-25461005
[Presentation] マウス脂肪肝炎におけるPD-1陽性T細胞の発現解析2015
- Author(s)
  山口寛二、岡嶋亮、伊藤義人．
- Organizer
  第51回肝臓学会総会
- Place of Presentation
  熊本
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-25461005
[Presentation] マウス脂肪肝炎における Heat shock蛋白Apg-2の役割についての検討2015
- Author(s)
  山口寛二、石破博、伊藤義人
- Organizer
  日本肝臓学会西部会
- Place of Presentation
  名古屋
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-15K09018
[Presentation] マウス脂肪肝、脂肪性肝炎モデルにおけるIL-6と肝脂肪化の関係について2009
- Author(s)
  山口寛二、伊藤義人、横溝千尋、西村健、新美敏久、岡上武、吉川敏一
- Organizer
  第38回日本肝臓学会西部会
- Place of Presentation
  鳥取
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20790503
[Presentation] Blockade of Interleukin 6 Trans-Signaling Enhanced Hepatic Steatosis but Improved Liver Injury in Methionine Choline Deficiency Diet-Fed Mice2009
- Author(s)
  山口寛二
- Organizer
  第54回アメリカ肝臓学会
- Place of Presentation
  アメリカ、ボストン
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-20790503
[Presentation] マウス脂肪性肝炎モデルにおけるDGAT ASOの効果について2008
- Author(s)
  山口寛二、伊藤義人、横溝千尋、西村健、新美敏久、岡上武、吉川敏一
- Organizer
  第44回日本肝臓学会総会ワークショップ
- Place of Presentation
  愛媛
- Year and Date
  2008-06-04
- Data Source
  KAKENHI-PROJECT-20790503
[Presentation] Inhibiting Interleukin-6/GP130 Signaling in Hepatocytes Worsens Hepatic Steatosis and Fibrosis in Lean and db/db mice Fed Methionine Choline Deficient Diets.2008
- Author(s)
  Kanji Yamaguchi, Yoshito Itoh, Toshihisa Niimi, Norihiro Mitsuyoshi, Koichiro Yasui, Masahito Minami, Masaki Iwai, Okanoue Takeshi, Toshikazu Yoshikawa
- Organizer
  第59回アメリカ肝臓病学会(ポスター)
- Place of Presentation
  サンフランシスコアメリカ
- Year and Date
  2008-11-03
- Data Source
  KAKENHI-PROJECT-20790503

1. ITOH Yoshito (70244613)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. Itoh Katsuhiko (90281097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. KOJIMA Soichi (10202061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KOSE Shingo (90333278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUURA Tomokazu (30199749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Fujita Jun (50173430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamaguchi Kanji 山口 寛二

YAMAGUCHI KANJI 山口 寛二

YAMAGUCHI Kanji 山口 寛二

Research Projects

Research Products

Co-Researchers

The development of steatohepatitis treatment via chaperone-associated ubiquitination by the heat shock protein Apg-2.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of heat shock protein Apg-2 in hepatic lipogenesis and hepatocarcinogenesis by using liver organoids.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of Apg-2 in human NAFLD

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of heat shock protein Apg-2 in hepatic lipogenesis and hepatocarcinogenesis by the inhibition of lipophagyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of HSP110 family, Apg-2 in NASH-related hepatic lipid and glucose metabolism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Apg-2 in liver steatosis and carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Examination about the association between intrahepatic immunogenicity and the expression of regulatory molecules on hepatic T cells in mouse NASH model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on a role of a crosslinking enzyme, transglutaminase in pathogenesis of liver diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of DGAT on liver steatosis, fibrosis and carcinogenesis in murine NASH models.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肝胆膵 NASH/NAFLDの臨床の進歩と問題点 オベチコール酸（DSP-1747）によるNASH治療2018

Author(s)

Total Pages

Publisher

Data Source

[Book] ＮＡＳＨにおける肝癌発生の実態2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat2020

Author(s)

Journal Title

DOI

Data Source

Yamaguchi Kanji 山口寛二

YAMAGUCHI KANJI 山口寛二

YAMAGUCHI Kanji 山口寛二

[Book] 肝胆膵 NASH/NAFLDの臨床の進歩と問題点オベチコール酸（DSP-1747）によるNASH治療2018

[Presentation] 20.FGF21-FGFR1/β-klotho 経路を介した非アルコール性脂肪性肝疾患（NAFLD）の治療戦略.2022