Kasahara Naoya 笠原尚哉

Researcher Number	50382891
Other IDs	https://orcid.org/0000-0002-7952-1276
Affiliation (Current)	2024: 自治医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2014 – 2023: 自治医科大学, 医学部, 助教 2017: 自治医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator General surgery / Basic Section 59040:Nutrition science and health science-related / Basic Section 90110:Biomedical engineering-related
Keywords	Principal Investigator 腸管不全関連肝障害 / ポリアミン / 短腸症 / ＩｇA / 腸管不全合併肝障害 / メタボローム解析 / 腸内細菌 / タイトジャンクション / IgA / 脂肪肝 / 小腸不全関連肝障害 / 腸管免疫 … More Except Principal Investigator … More 臓器再生 / 脱細胞化臓器 / 腸幹細胞 / グルコース代謝 / ケトン体 / 栄養素吸収 / 小腸 / 栄養素シグナル / 摂食 / 絶食 / SGLT1 / クローディン / グルコース吸収 / 上部小腸 / オルガノイド / 細胞系譜 / 移植・再生医療 / 生体医工学 / 細胞培養 / 大動物実験 / 再生医療 / 臓器移植 / NASH / 肥満 / 脂肪肝 / 褐色脂肪 / 非アルコール性脂肪肝炎 / 肥満治療 / 脂肪幹細胞 / 褐色細胞腫 / 細胞移植 / 表面マーカー / 褐色脂肪細胞 Less

脱細胞化臓器を担体とした生体外臓器再生技術の開発
- Principal Investigator
  
  浦橋泰然
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Dokkyo Medical University
Elucidation of the physiological significance of the energy sensing system in the proximal small intestine
- Principal Investigator
  
  林久由
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  University of Shizuoka
Dietary spermidine and spermine intake strengthen intestine barrier and prevent hepatocyte lipid droplet deposition in rodent short bowel syndrome modelPrincipal Investigator
- Principal Investigator
  
  Kasahara Naoya
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical University
Development for recellularized liver graft derived from decellularized liver matrix in porcine model
- Principal Investigator
  
  Urahashi Taizen
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Dokkyo Medical University
  Jichi Medical University
Novel treatment for non-alcoholic hepatitis inducing human brown adipose tissue
- Principal Investigator
  
  SAKUMA YASUNARU
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical University
Oral administration of polyamines promote adaptation in rodent model of short bowel syndromePrincipal Investigator
- Principal Investigator
  
  Kasahara Naoya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical University

All 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Patent

[Journal Article] Bolus Administration of Polyamines Boosts Effects on Hepatic Ischemia-Reperfusion Injury and Regeneration in Rats2019
- Author(s)
  Doi Junshi、Fujimoto Yasuhiro、Teratani Takumi、Kasahara Naoya、Maeda Masashi、Tsuruyama Tatsuaki、Iida Taku、Yagi Shintaro、Uemoto Shinji
- Journal Title
  
  European Surgical Research
  
  Volume: 60 Issue: 1-2 Pages: 63-73
- DOI
  10.1159/000497434
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10563, KAKENHI-PROJECT-18H04058, KAKENHI-PROJECT-17K10519, KAKENHI-PROJECT-19K22656
[Journal Article] Oral administration of polyamines ameliorates liver ischemia-reperfusion injury and promotes liver regeneration in rats.2016
- Author(s)
  Okumura S, Teratani T, Fujimoto Y, Zhao X, Tsuruyama T, Masano Y, Kasahara N, Iida T, Yagi S, Uemura T, Kaido T, Uemoto S.
- Journal Title
  
  Liver Transplantation
  
  Volume: XXX Issue: 9 Pages: 1-1
- DOI
  10.1002/lt.24471
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461926, KAKENHI-PROJECT-25461967
[Journal Article] Orthotopic mouse liver transplantation to study liver biology and allograft tolerance.2016
- Author(s)
  Yokota S, Ueki S, Ono Y, Kasahara N, Pérez-Gutiérrez A, Kimura S, Yoshida O, Murase N, Yasuda Y, Geller D, Thomson A
- Journal Title
  
  Nature Protocols
  
  Volume: XXX
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461926
[Patent] 脱細胞化担体製造方法、脱細胞化担体、細胞充填方法、細胞シート作製方法、及び脱細胞化溶液キット2018
- Inventor(s)
  寺谷工、浦橋泰然、笠原尚哉
- Industrial Property Rights Holder
  寺谷工、浦橋泰然、笠原尚哉
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K10563
[Patent] ポリアミンを有効成分とする、造精機能障害を改善するための組成物2017
- Inventor(s)
  渡邉卓巳、寺谷工、笠原尚哉、高山達也
- Industrial Property Rights Holder
  渡邉卓巳、寺谷工、笠原尚哉、高山達也
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-17K10563
[Patent] ポリアミンを有効成分とする、組織の再生を促進するための組成物（分割出願）2016
- Inventor(s)
  寺谷工、笠原尚哉
- Industrial Property Rights Holder
  寺谷工、笠原尚哉
- Industrial Property Rights Type
  特許
- Filing Date
  2016-04-01
- Data Source
  KAKENHI-PROJECT-26461926
[Patent] ポリアミンを有効成分とする、軟骨組織の再生を促進するための組成物2015
- Inventor(s)
  寺谷工、笠原尚哉
- Industrial Property Rights Holder
  寺谷工、笠原尚哉
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-01
- Data Source
  KAKENHI-PROJECT-26461926
[Patent] ポリアミンを有効成分とする、造精機能障害を改善するための組成物2015
- Inventor(s)
  寺谷工、笠原尚哉
- Industrial Property Rights Holder
  寺谷工、笠原尚哉
- Industrial Property Rights Type
  特許
- Filing Date
  2015-10-01
- Data Source
  KAKENHI-PROJECT-26461926
[Patent] ポリアミンを有効成分とする造精機能障害を改善するための組成物2014
- Inventor(s)
  寺谷工、笠原尚哉
- Industrial Property Rights Holder
  寺谷工、笠原尚哉
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-01
- Acquisition Date
  2015-04-01
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 脱細胞化臓器を用いた移植可能な再生臓器技術の展望　「再肝臓化」した肝および腎グラフトの開発を中心に2016
- Author(s)
  浦橋泰然、笠原尚哉、寺谷工
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2016-04-16
- Data Source
  KAKENHI-PROJECT-15K10066
[Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明2016
- Author(s)
  笠原尚哉, 寺谷工, 横田真一郎, 三木厚, 浦橋泰然, 藤本康弘, 佐久間康成, 佐田尚宏
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  徳島県徳島市あわぎんホール
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 「腎臓を肝臓化する試み」ブタ臓器脱細胞化技術を用いた肝細胞充填腎グラフトの開発2016
- Author(s)
  浦橋泰然、笠原尚哉、寺谷工
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-15K10066
[Presentation] 脱細胞化臓器は別機能を持った新たな臓器と変わり得るか？ブタ臓器脱細胞化技術を用いた肝細胞充填肝グラフトおよび腎グラフトの開発2015
- Author(s)
  浦橋泰然、笠原尚哉、寺谷工
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-15K10066
[Presentation] 笠原尚哉, 寺谷工, 三木厚, 佐久間康成, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和：短腸症モデルラットを用いたポリアミン摂取による治療効果の検討2015
- Author(s)
  笠原尚哉, 寺谷工, 三木厚, 佐久間康成, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台市
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討2015
- Author(s)
  笠原尚哉
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明2015
- Author(s)
  笠原尚哉, 寺谷工, 三木厚, 佐久間康成, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和
- Organizer
  第70回日本消化器外科学会総会
- Place of Presentation
  浜松市
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明2015
- Author(s)
  笠原尚哉
- Organizer
  第70回日本消化器外科学会総会
- Place of Presentation
  浜松
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 間葉系幹細胞分泌因子添加による小腸移植成績の改善2015
- Author(s)
  笠原尚哉, 寺谷工, 土井淳司, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和, 小林英司
- Organizer
  第115回日本外科学会学術集会
- Place of Presentation
  名古屋市
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26461926

1. 寺谷工 (70373404)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
2. Urahashi Taizen (90277161)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. SAKUMA YASUNARU (10296105)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 三木厚 (20570378)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 安田是和 (40158001)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 上本伸二 (40252449)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 藤本康弘 (80335281)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
8. 佐田尚宏 (20261977)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. 小林英司 (00245044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 横田真一郎 (00625551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岩本禎彦 (10232711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 望月和樹 (80423838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 重田孝信 (60560331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 吉富秀幸 (60375631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 林久由 (40238118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 石塚典子 (30440283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kasahara Naoya 笠原 尚哉

Research Projects

Research Products

Co-Researchers

脱細胞化臓器を担体とした生体外臓器再生技術の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the physiological significance of the energy sensing system in the proximal small intestine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dietary spermidine and spermine intake strengthen intestine barrier and prevent hepatocyte lipid droplet deposition in rodent short bowel syndrome modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development for recellularized liver graft derived from decellularized liver matrix in porcine model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel treatment for non-alcoholic hepatitis inducing human brown adipose tissue

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oral administration of polyamines promote adaptation in rodent model of short bowel syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Bolus Administration of Polyamines Boosts Effects on Hepatic Ischemia-Reperfusion Injury and Regeneration in Rats2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oral administration of polyamines ameliorates liver ischemia-reperfusion injury and promotes liver regeneration in rats.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Orthotopic mouse liver transplantation to study liver biology and allograft tolerance.2016

Author(s)

Journal Title

Data Source

[Patent] 脱細胞化担体製造方法、脱細胞化担体、細胞充填方法、細胞シート作製方法、及び脱細胞化溶液キット2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] ポリアミンを有効成分とする、造精機能障害を改善するための組成物2017

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Patent] ポリアミンを有効成分とする、組織の再生を促進するための組成物（分割出願）2016

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] ポリアミンを有効成分とする、軟骨組織の再生を促進するための組成物2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] ポリアミンを有効成分とする、造精機能障害を改善するための組成物2015

Kasahara Naoya 笠原尚哉

[Presentation] 脱細胞化臓器を用いた移植可能な再生臓器技術の展望　「再肝臓化」した肝および腎グラフトの開発を中心に2016

[Presentation] 笠原尚哉, 寺谷工, 三木厚, 佐久間康成, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和：短腸症モデルラットを用いたポリアミン摂取による治療効果の検討2015