KAWATANI Makoto 川谷誠

… Alternative Names

川谷誠カワタニマコト

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Researcher Number	50391925
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2015 – 2023: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 2015: 理化学研究所, 基幹研究所, 研究員 2013 – 2014: 独立行政法人理化学研究所, 長田抗生物質研究室, 専任研究員 2012: 独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 専任研究員 2012: 独立行政法人理化学研究所, 基幹研究所, 研究員 … More 2009 – 2011: The Institute of Physical and Chemical Research, 化合物ライブラリー評価研究チーム, 研究員 2007 – 2008: 独立行政法人理化学研究所, 長田抗生物質研究室, 協力研究員 2007: The Institute of Physical and Chemical Research, 長田抗生物質研究室, 協力研究員 2006: 独立行政法人理化学研究所, 長田抗生物質研究室, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Living organism molecular science / Basic Section 37030:Chemical biology-related / Chemical biology Except Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Complex systems / Bioorganic chemistry
Keywords	Principal Investigator がん / 阻害剤 / 代謝 / 癌 / 抗がん剤 / エンドサイトーシス / 小分子化合物 / UBL-UBA型ユビキチンレセプター / 分子標的治療薬 / Glyoxalase I / Methyl-gerfelin / 破骨細胞 / 骨転移 … More Except Principal Investigator … More maoecrystal V / JBIR-23 / enacyloxins / 全合成 / 単離構造決定 / 抗生物質 / ユビキチンデコーダ / アルキン / アジド / ユビキチンデコーダー / スプライシング / アグリソーム / クリック反応 / ライブラリー合成 / UbTACs / E3リガンド / 化合物アレイ / リガンド化合物 / ユビキチン化誘導キメラ分子 / ユビキチンリガーゼ / cortistain / echinopine / organocuprate / sanctolide A / thelepamide / sanctlide A / taxane / enacyloxin / sialidase / terpenoids / polyketides / marine products / antibitics / total synthesis / structure elucidation / echinopines / Aspergillus puniceus / cortistatins / 抗性物質 / ステロイド / ポリケチド / テルペノイド / 海洋物質 / 天然物 / 構造活性相関 / タキサンジテルペノイド / ジャスモン酸 / 海洋天然物 / 植物毒素 / クラスター解析 / HeLa細胞 / プロテオーム解析 / 標的分子 / 阻害剤 / プロテオミクス / target Protein / proteome analysis / 2D-DIGE / target protein / small molecule / proteomic analysis Less

小分子化合物によるグルコース非依存性がん代謝機構の理解と制御Principal Investigator
- Principal Investigator
  
  川谷誠
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
Development of small-molecule inhibitors targeting the metabolic switch in cancer cellsPrincipal Investigator
- Principal Investigator
  
  Kawatani Makoto
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Institute of Physical and Chemical Research
Chemical biology for controlling ubiquitin function
- Principal Investigator
  
  Yoshida Minoru
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Institute of Physical and Chemical Research
Development of small-molecule inhibitors targeting glucose-independent cancer metabolismPrincipal Investigator
- Principal Investigator
  
  Kawatani Makoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Institute of Physical and Chemical Research
Development of novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathwayPrincipal Investigator
- Principal Investigator
  
  Kawatani Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Institute of Physical and Chemical Research
Development of agrochemical and pharmaceutical lead compounds based on the search and total synthesis of natural compounds with a unique structure and biological activity
- Principal Investigator
  
  Kiyota Hiromasa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Okayama University
Total synthesis and investigation of biologically active natural compounds with novel and complex structures and its application to the development of agricultural and pharmaceutical lead compounds
- Principal Investigator
  
  KIYOTA Hiromasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tohoku University
Development of anti-cancer agents targeting the endocytic pathwayPrincipal Investigator
- Principal Investigator
  
  KAWATANI Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
Development of a novel anticancer drug targeting UBL-UBA family proteinPrincipal Investigator
- Principal Investigator
  
  KAWATANI Makoto
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research
プロテオミックス的手法を用いた薬剤作用解析システムの構築
- Principal Investigator
  
  MUROI Makoto
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The Institute of Physical and Chemical Research
癌骨転移に対する分子標的治療薬の開発Principal Investigator
- Principal Investigator
  
  川谷誠
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 細胞骨格系、分子標的薬　－がんから他疾患までの治癒をめざして－2012
- Author(s)
  川谷誠　他
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22681034
[Book] 「細胞骨格系」日本臨床(増刊号)2012
- Author(s)
  川谷誠、長田裕之
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling2023
- Author(s)
  KAWATANI MAKOTO、AONO HARUMI、HIRANUMA SAYOKO、SHIMIZU TAKESHI、MUROI MAKOTO、NOGAWA TOSHIHIKO、OHISHI TOMOKAZU、OHBA SHUN-ICHI、KAWADA MANABU、YAMAZAKI KANAMI、DAN SHINGO、DOHMAE NAOSHI、OSADA HIROYUKI
- Journal Title
  
  Oncology Research
  
  Volume: 31 Issue: 6 Pages: 833-844
- DOI
  10.32604/or.2023.030241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-22K05363, KAKENHI-PROJECT-22K06783, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04720
[Journal Article] Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors2023
- Author(s)
  Motoyama Takayuki、Nogawa Toshihiko、Shimizu Takeshi、Kawatani Makoto、Kashiwa Takeshi、Yun Choong-Soo、Hashizume Daisuke、Osada Hiroyuki
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 18 Issue: 2 Pages: 396-403
- DOI
  10.1021/acschembio.2c00830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05820, KAKENHI-PROJECT-22K05363, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05858, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-21H04720
[Journal Article] Identification of a small molecule that enhances ferroptosis via inhibition of FSP1.2022
- Author(s)
  Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 17 Issue: 2 Pages: 483-491
- DOI
  10.1021/acschembio.2c00028
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H04720, KAKENHI-PUBLICLY-21H00295, KAKENHI-PLANNED-17H06412
[Journal Article] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite2022
- Author(s)
  Mendoza, A., Takemoto, Y., Cruzado, KT., Masoud, SS., Nagata, A., Tantipanjaporn, A., Okuda, S., Kawagoe, F., Sakamoto, R., Odagi, M., Mototani, S., Togashi, M., Kawatani, M., Aono, H., Osada, H., Nakagawa, H., Higashi, T., Kittaka, A., Nagasawa, K., Uesugi, M.
- Journal Title
  
  Cell Chem Biol.
  
  Volume: 29 Issue: 4 Pages: 660-669
- DOI
  10.1016/j.chembiol.2021.08.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06408, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-19H02889, KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-22K05363, KAKENHI-PROJECT-22K19101, KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-18H05503, KAKENHI-PLANNED-17H06412
[Journal Article] Local administration of ReveromycinA ointment suppressed alveolar bone loss in mice2021
- Author(s)
  Miyazawa Ken、Asano Yuichiro、Tabuchi Masako、Kako Shunsuke、Kawatani Makoto、Osada Hiroyuki、Maeda Hatsuhiko、Goto Shigemi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 147 Issue: 1 Pages: 40-47
- DOI
  10.1016/j.jphs.2021.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412
[Journal Article] Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth2021
- Author(s)
  Kawatani Makoto、Aono Harumi、Shimizu Takeshi、Ohkura Shouta、Hiranuma Sayoko、Muroi Makoto、Ogawa Naoko、Ohishi Tomokazu、Ohba Shun-ichi、Kawada Manabu、Yamazaki Kanami、Dan Shingo、Osada Hiroyuki
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 16 Issue: 11 Pages: 2570-2580
- DOI
  10.1021/acschembio.1c00625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-21H04720, KAKENHI-PLANNED-17H06412
[Journal Article] Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth2021
- Author(s)
  Kawatani Makoto、Aono Harumi、Hiranuma Sayoko、Shimizu Takeshi、Muroi Makoto、Ogawa Naoko、Ohishi Tomokazu、Ohba Shun-ichi、Kawada Manabu、Nogawa Toshihiko、Okano Akiko、Hashizume Daisuke、Osada Hiroyuki
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 16 Issue: 8 Pages: 1576-1586
- DOI
  10.1021/acschembio.1c00480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-20K05858, KAKENHI-PROJECT-16H06276, KAKENHI-PLANNED-17H06412
[Journal Article] Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects?2021
- Author(s)
  Kako Shunsuke、Tabuchi Masako、Miyazawa Ken、Tanaka Miyuki、Minamoto Chisato、Asano Yuichiro、Kimura Fumika、Aoki Yuki、Sato Takuma、Kawatani Makoto、Osada Hiroyuki、Maeda Hatsuhiko、Goto Shigemi
- Journal Title
  
  European Journal of Orthodontics
  
  Volume: - Issue: 6 Pages: 658-664
- DOI
  10.1093/ejo/cjaa067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09870, KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412
[Journal Article] Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma.2020
- Author(s)
  Keiichiro Watanabe、Ariunzaya Bat-Erdene、Hirofumi Tenshin、Qu Cui、Jumpei Teramachi、Masahiro Hiasa、Asuka Oda、Takeshi Harada、Hirokazu Miki、Kimiko Sogabe、Masahiro Oura、Ryohei Sumitani、Yukari Mitsui、Itsuro Endo、Eiji Tanaka、Makoto Kawatani、Hiroyuki Osada、Toshio Matsumoto、Masahiro Abe
- Journal Title
  
  Haematologica
  
  Volume: 106 Issue: 4 Pages: 1172-1177
- DOI
  10.3324/haematol.2019.244418
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08329, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-19K22719, KAKENHI-PROJECT-17KK0169, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17H05104, KAKENHI-PROJECT-20K18784
[Journal Article] Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana2020
- Author(s)
  Sako Kaori、Futamura Yushi、Shimizu Takeshi、Matsui Akihiro、Hirano Hiroyuki、Kondoh Yasumitsu、Muroi Makoto、Aono Harumi、Tanaka Maho、Honda Kaori、Shimizu Kenshirou、Kawatani Makoto、Nakano Takeshi、Osada Hiroyuki、Noguchi Ko、Seki Motoaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 8691-8691
- DOI
  10.1038/s41598-020-65614-9
- NAID
  120006876594
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-19K05744, KAKENHI-PROJECT-20K05857, KAKENHI-PROJECT-18K14441, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-18H02140, KAKENHI-PROJECT-18K05366
[Journal Article] Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA2020
- Author(s)
  Nagasawa Ikuko、Muroi Makoto、Kawatani Makoto、Ohishi Tomokazu、Ohba Shun-ichi、Kawada Manabu、Osada Hiroyuki
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27 Issue: 2 Pages: 1-11
- DOI
  10.1016/j.chembiol.2019.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08693, KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-19K15717, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K05857
[Journal Article] Alteration of tooth movement by reveromycin A in OPG KO mice2020
- Author(s)
  Minamoto C., Miyazawa K., Tabuchi M., Tanaka H., Mizuno M., Yoshizako M., Torii Y., Tamaoka Y., Asano Y., Kawatani M., Osada H., Maeda H., and Goto S.
- Journal Title
  
  Am. J. Orthod. Dentofacial Orthop.
  
  Volume: 157 Issue: 5 Pages: 680-689
- DOI
  10.1016/j.ajodo.2019.04.037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18K09870
[Journal Article] Structure and biological activity of metarhizin C, a new stereoisomer of BR-050 from a fungus Tolypocladium album RK17-F00072019
- Author(s)
  Nogawa T., Kawatani M., Okano A., Futamura Y., Aono H., Shimizu T., Kato N., Kikuchi H., and Osada H.
- Journal Title
  
  J. Antibiot.
  
  Volume: 72 Issue: 12 Pages: 996-1000
- DOI
  10.1038/s41429-019-0229-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05744, KAKENHI-PLANNED-17H06412, KAKENHI-PUBLICLY-19H04665, KAKENHI-PROJECT-17H01472, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07784
[Journal Article] Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.2019
- Author(s)
  Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
- Journal Title
  
  Biochim Biophys Acta Proteins Proteom.
  
  Volume: 1867 Issue: 1 Pages: 28-37
- DOI
  10.1016/j.bbapap.2018.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01970, KAKENHI-PROJECT-17K07783, KAKENHI-PROJECT-17K07784, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945, KAKENHI-PROJECT-16K01941
[Journal Article] Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K2017
- Author(s)
  Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M
- Journal Title
  
  Sci Rep
  
  Volume: - Issue: 1 Pages: 41710-41710
- DOI
  10.1038/srep41710
- NAID
  120006313626
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01634, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-14J06672, KAKENHI-PROJECT-26461909, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16K10101, KAKENHI-PROJECT-15K15540
[Journal Article] Structure-activity relationships of terpendole E and its natural derivatives.2017
- Author(s)
  Nagumo Y., Motoyama T., Hayashi T., Hirota H., Aono H., Kawatani M., Osada H., and Usui T.
- Journal Title
  
  ChemistrySelect
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01941
[Journal Article] Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors.2016
- Author(s)
  Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KY
- Journal Title
  
  Chem Biol Drug Des
  
  Volume: - Issue: 6 Pages: 862-869
- DOI
  10.1111/cbdd.12909
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-15K16563, KAKENHI-PROJECT-16K01941, KAKENHI-PLANNED-17H06412
[Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator.2016
- Author(s)
  Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 38385-38385
- DOI
  10.1038/srep38385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276
[Journal Article] An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae2016
- Author(s)
  Shinohara Y, Kawatani M, Futamura Y, Osada H, Koyama Y
- Journal Title
  
  J Antibiot
  
  Volume: 69 Issue: 1 Pages: 4-8
- DOI
  10.1038/ja.2015.73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-16K01941
[Journal Article] Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters.2016
- Author(s)
  S. Katsuyama, K. Sugino, Y. Sasazawa, Y. Nakano, H. Aono, K. Morishita, M. Kawatani, K. Umezawa, H. Osada and S. Simizu
- Journal Title
  
  FEBS Letters
  
  Volume: 590 Issue: 8 Pages: 1152-1162
- DOI
  10.1002/1873-3468.12146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350975, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-26750373, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16J40133, KAKENHI-PROJECT-16K01941
[Journal Article] Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library2016
- Author(s)
  Lim CL., Nogawa T., Okano A., Futamura Y., Kawatani M., Takahashi S. Ibrahim D., Osada H.
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: AOP Issue: 6 Pages: 456-458
- DOI
  10.1038/ja.2015.124
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450148, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-16K01941
[Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival.2016
- Author(s)
  Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 26521-26521
- DOI
  10.1038/srep26521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-26350976, KAKENHI-PROJECT-15K16563, KAKENHI-PROJECT-16K01941, KAKENHI-PROJECT-16H06276
[Journal Article] 分子標的同定の実例2015
- Author(s)
  井本正哉、川谷誠
- Journal Title
  
  CSJカレントレビュー19
  
  Volume: - Pages: 1273-1280
- Data Source
  KAKENHI-PROJECT-25350981
[Journal Article] Reveromycin A Administration Prevents Alveolar Bone Loss in Osteoprotegerin Knockout Mice with Periodontal Disease2015
- Author(s)
  Mizuno M, Miyazawa K, Tabuchi M, Tanaka M, Yoshizako M, Minamoto C, Torii Y, Tamaoka Y, Kawatani M, Osada H, Maeda H, Goto S
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 16510-16510
- DOI
  10.1038/srep16510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25463207
[Journal Article] ケミカルバイオロジーと新規分子標的薬2015
- Author(s)
  川谷誠、長田裕之
- Journal Title
  
  日本臨牀
  
  Volume: 73 Pages: 1273-1280
- Data Source
  KAKENHI-PROJECT-25350981
[Journal Article] Identification of matrix metalloproteinase inhibitors by chemical arrays.2015
- Author(s)
  Kawatani M., Fukushima Y., Kondoh Y., Honda K., Sekine T., Yamaguchi Y., Taniguchi N., and Osada H.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25350981
[Journal Article] Neuritogenic Activity of Tetradecyl 2,3-Dihydroxybenzoate Is Mediated through the Insulin-Like Growth Factor 1 Receptor/Phosphatidylinositol 3 Kinase/Mitogen-Activated Protein Kinase Signaling Pathway2015
- Author(s)
  Tang R, Gao L, Kawatani M, Chen J, Cao X, Osada H, Xiang L, Qi J
- Journal Title
  
  Mol Pharmacol
  
  Volume: 88 Issue: 2 Pages: 326-334
- DOI
  10.1124/mol.115.097758
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02445, KAKENHI-PROJECT-25350981
[Journal Article] Affinity-based target identification for bioactive small molecules2014
- Author(s)
  Kawatani M., and Osada H.
- Journal Title
  
  MedChemComm
  
  Volume: 5 Issue: 3 Pages: 277-287
- DOI
  10.1039/c3md00276d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350981
[Journal Article] A small molecule that induces reactive oxygen species via cellular glutathione depletion.2014
- Author(s)
  Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.
- Journal Title
  
  Biochem J
  
  Volume: 463 Issue: 1 Pages: 53-63
- DOI
  10.1042/bj20140669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750397, KAKENHI-PROJECT-26350976
[Journal Article] Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T2014
- Author(s)
  Shunji Takahashi, Shingo Nagano, Toshihiko Nogawa, Naoki Kanoh, Masakazu Uramoto, Makoto Kawatani, Yoshitsugu Shiro, Hiroyuki Osada
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Issue: 47 Pages: 32446-32458
- DOI
  10.1074/jbc.m114.598391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102013, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25291015, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-26450148
[Journal Article] Polarization of osteoclasts on dental implant materials is similar to that observed on bone.2014
- Author(s)
  Nakayama T., Thirukonda G. J., Nagasawa S., Kawahara I, Udagawa N., Yagami K., Kawatani M., Osada H., Doi Y., Yoshinari N., and Takahashi N.
- Journal Title
  
  J. Oral Biosci.
  
  Volume: 56 Issue: 4 Pages: 136-142
- DOI
  10.1016/j.job.2014.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25463059, KAKENHI-PROJECT-26463148
[Journal Article] Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice2013
- Author(s)
  Yabumoto T., Miyazawa K., Tabuchi M., Shoji S., Tanaka M., Kadota M., Yoshizako M., Kawatani M., et al.
- Journal Title
  
  Am. J. Orthod. Dentofacial Orthop.
  
  Volume: 144 Issue: 3 Pages: 368-380
- DOI
  10.1016/j.ajodo.2013.04.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350981
[Journal Article] Creation of novel reveromycin derivatives by alcohol added fermentation2013
- Author(s)
  Nogawa T. et al.
- Journal Title
  
  J. Antibiot.
  
  Volume: 66 Issue: 4 Pages: 247-250
- DOI
  10.1038/ja.2012.115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25350981
[Journal Article] Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems.2013
- Author(s)
  Futamura Y, Kawatani M, Muroi M, Aono H, Nogawa T, Osada H,
- Journal Title
  
  ChemBioChem
  
  Volume: 14 Issue: 18 Pages: 2456-2463
- DOI
  10.1002/cbic.201300499
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102536, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981, KAKENHI-PROJECT-25750396
[Journal Article] Dual Structure-Activity Relationship of Osteoclastogenesis Inhibitor Methyl Gerfelin Based on TEG Scanning2013
- Author(s)
  Kanoh, N.
- Journal Title
  
  Bioconjugate Chem.
  
  Volume: 24 Issue: 1 Pages: 44-52
- DOI
  10.1021/bc3003666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310132, KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-25350981, KAKENHI-PLANNED-23102013
[Journal Article] Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus.2013
- Author(s)
  Nogawa T, Kawatani M, Uramoto M, Okano A, Aono H, Futamura Y, Koshino H, Takahashi S, Osada H.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 66 Issue: 10 Pages: 621-623
- DOI
  10.1038/ja.2013.55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-24380052, KAKENHI-PROJECT-24658088, KAKENHI-PUBLICLY-25108726, KAKENHI-PROJECT-25350981
[Journal Article] Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning.2013
- Author(s)
  Kanoh N., Suzuki T., Kawatani M., Katou Y., Oshima Y., Osada H., and Iwabuchi Y.
- Journal Title
  
  Bioconjug. Chem.
  
  Volume: 24 Pages: 44-52
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Isolation of new polyketide metabolites, linearolides A and B, from a Streptomyces sp. RK95-742013
- Author(s)
  Ueki M. et al.
- Journal Title
  
  J. Antibiot.
  
  Volume: - Issue: 6 Pages: 333-337
- DOI
  10.1038/ja.2013.19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-24248022, KAKENHI-PROJECT-25350981
[Journal Article] Effect of reveromycin A on experimental tooth movement in OPG-/- mice.2012
- Author(s)
  Tanaka M., Miyazawa K., Tabuchi M., Yabumoto T., Kadota M., Yoshizako M., Yamane C., Kawatani M., Osada H., Maeda H., and Goto S.
- Journal Title
  
  J. Dent. Res.
  
  Volume: 91 Pages: 771-776
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9.2012
- Author(s)
  Khan M. M., Simizu S., Suzuki T., Masuda, A., Kawatani M., Muroi M., Dohmae N., and Osada H.
- Journal Title
  
  Exp. Cell Res.
  
  Volume: 318 Pages: 904-914
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library.2012
- Author(s)
  Nogawa T., Takahashi S., Okano A., Kawatani M., Uramoto M., Saito T., and Osada H.
- Journal Title
  
  J. Antibiot.
  
  Volume: 65 Pages: 123-128
- NAID
  10030711040
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Violaceols function as actin inhibitors inducing cell shape elongation in fibroblast cells.2012
- Author(s)
  Asami Y., Jang J.-H., Oh H., Sohn J. H., Kim J. W., Moon D. O., Kwon O., Kawatani M., Osada H., Kim B. Y., and Ahn J. S.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 76 Pages: 1431-1437
- NAID
  10031065548
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] The potential of protein disulfide isomerase as a therapeutic drug target.2012
- Author(s)
  Khan M. M., Simizu S., Kawatani M., and Osada H.
- Journal Title
  
  Oncol. Res.
  
  Volume: 19 Pages: 445-453
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.2012
- Author(s)
  Futamura Y., Kawatani M., Kazami S., Tanaka K., Muroi M., Shimizu T., Tomita K., Watanabe N., and Osada H.
- Journal Title
  
  Chem. Biol.
  
  Volume: 19 Pages: 1620-1630
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Genetic safeguard against mycotoxin cyclopiazonic acid production in Aspergillus oryzae.2011
- Author(s)
  Kato N., Tokuoka M., Shinohara Y., Kawatani M., Uramoto M., Seshime Y., Fujii I., Kitamoto K., Takahashi T., Takahashi S., Koyama Y., and Osada, H.
- Journal Title
  
  Chembiochem
  
  Volume: 12 Pages: 1376-1382
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling2011
- Author(s)
  Kawatani M., et al
- Journal Title
  
  Chem.Biol.
  
  Volume: 18 Issue: 6 Pages: 743-751
- DOI
  10.1016/j.chembiol.2011.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22681034, KAKENHI-PROJECT-221S0001
[Journal Article] Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.2011
- Author(s)
  Khan M. M., Simizu S., Lai N. S., Kawatani M., Shimizu T., and Osada H.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 6 Pages: 245-251
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.2011
- Author(s)
  Kawatani M., Takayama H., Muroi M., Kimura S., Maekawa T., and Osada H.
- Journal Title
  
  Chem. Biol.
  
  Volume: 18 Pages: 743-751
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.2010
- Author(s)
  Muroi M., Kazami S., Noda K., Kondo H., Takayama H., Kawatani M., Usui T., and Osada H.
- Journal Title
  
  Chem. Biol.
  
  Volume: 17 Pages: 460-470
- NAID
  120007137992
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in hypoxic environment.2010
- Author(s)
  Takeuchi M., Kimura S., Kuroda J., Ashihara E., Kawatani M., Osada H., Umezawa K., Yasui E., Imoto M., Tsuruo T., Yokota A., Tanaka R., Nagao R., Nakahata T., Fujiyama Y., and Maekawa T.
- Journal Title
  
  Cell Death Diff.
  
  Volume: 17 Pages: 1211-1220
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] グリオキサラーゼI2009
- Author(s)
  川谷誠
- Journal Title
  
  Medical Tribune 42
  
  Pages: 50-50
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] 破骨細胞の分化を阻害する小分子化合物2009
- Author(s)
  川谷誠, 他
- Journal Title
  
  バイオサイエンスとインダストリー 67
  
  Pages: 24-28
- NAID
  10024745896
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] 破骨細胞を標的とする天然低分子化合物のケミカルジェネティクス2009
- Author(s)
  川谷誠, 他
- Journal Title
  
  細胞工学 28
  
  Pages: 338-344
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] 破骨細胞の分化を阻害する小分子化合物2009
- Author(s)
  川谷誠, 奥村英夫, 長田裕之
- Journal Title
  
  バイオサイエンスとインダストリー 67
  
  Pages: 24-28
- NAID
  10024745896
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] レドックス制御に干渉する小分子のケミカルバイオロジー2009
- Author(s)
  川谷誠, 他
- Journal Title
  
  実験医学(増刊) 27
  
  Pages: 218-224
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases2009
- Author(s)
  Kawatani, M., Osada, H.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 1999-2005
- NAID
  10027196327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] レドックス制御に干渉する小分子のケミカルバイオロジー2009
- Author(s)
  川谷誠, 奥村英夫, 長田裕之
- Journal Title
  
  実験医学(増刊) 27
  
  Pages: 218-224
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] 破骨細胞を標的とする天然低分子化合物のケミカルジェネティクス2009
- Author(s)
  川谷誠, 長田裕之
- Journal Title
  
  細胞工学 28
  
  Pages: 338-344
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis.2009
- Author(s)
  Kawatani M (7名中5番目)
- Journal Title
  
  Oncogene 28
  
  Pages: 107-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases.2009
- Author(s)
  Kawatani M, Osada H
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 1999-2005
- NAID
  10027196327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008
- Author(s)
  Kawatani M (11名中1番目)
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 11691-11696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives.2008
- Author(s)
  Kawatani M (10名中4番目)
- Journal Title
  
  Bioorg. Med. Chem. Lett. 18
  
  Pages: 3756-3760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I2008
- Author(s)
  Kawatani, M.
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 11691-11696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19658047
[Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I2008
- Author(s)
  Kawatani M., et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 11691-11696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II.2008
- Author(s)
  Kawatani M (5名中4番目)
- Journal Title
  
  Biosci. Biotechnol. Biochem. 72
  
  Pages: 2739-2749
- NAID
  10027533381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in hypoxic environment.
- Author(s)
  Kawatani M (16名中5番目)
- Journal Title
  
  Cell Death Diff. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710175
[Journal Article] Isolation of new polyketide metabolites, linearolides A and B, from a Streptomyces sp. RK95-74.
- Author(s)
  Ueki M., Koshiro N., Aono H., Kawatani M., Uramoto M., Kawasaki H., and Osada H.
- Journal Title
  
  J. Antibiot.
  
  Volume: (in press)
- NAID
  10031183840
- Data Source
  KAKENHI-PROJECT-22681034
[Journal Article] Creation of novel reveromycin derivatives by alcohol added fermentation.
- Author(s)
  Nogawa T., Takahashi S., Sekiyama Y., Takagi H., Uramoto M., Koshino H., Kawatani M., Shimizu T., and Osada H.
- Journal Title
  
  J. Antibiot.
  
  Volume: (in press)
- NAID
  10031168688
- Data Source
  KAKENHI-PROJECT-22681034
[Patent] 新規フラノクマリン誘導体及びその用途2023
- Inventor(s)
  川谷誠、長田裕之、青野晴美、平沼佐代子、清水猛
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-22K05363
[Patent] 新規フラノクマリン誘導体及びその用途2023
- Inventor(s)
  川谷誠、長田裕之、青野晴美、平沼佐代子、清水猛
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-19K05744
[Patent] 新規フラノクマリン誘導体及びその用途2023
- Inventor(s)
  川谷誠、長田裕之、青野晴美、平沼佐代子、清水猛
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PLANNED-18H05503
[Patent] 新規フラノクマリン誘導体及びその用途2022
- Inventor(s)
  川谷誠、長田裕之、青野晴美、平沼佐代子、清水猛
- Industrial Property Rights Holder
  川谷誠、長田裕之、青野晴美、平沼佐代子、清水猛
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-19K05744
[Patent] 新規ユビキリン結合性小分子2008
- Inventor(s)
  長田裕之、川谷誠、木村晋也、前川平、水戸潤
- Industrial Property Rights Holder
  理化学研究所、京都大学
- Filing Date
  2008-05-02
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] がん代謝阻害剤の探索と標的同定2023
- Author(s)
  川谷誠
- Organizer
  先端モデル動物支援プラットフォーム2022年度成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] Proteomics-based target identification system for biological active compounds, ChemProteoBase and 2DE-CETSA2023
- Author(s)
  Makoto Muroi, Makoto Kawatani, Emiko Sanada, Hiroyuki Osada, Naoshi Dohmae
- Organizer
  Future Drug Discovery Empowered by Chemical Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] 新規DHODH阻害剤NPD723の作用機構と構造活性相関2023
- Author(s)
  川谷誠、青野晴美、平沼佐代子、清水猛、室井誠、野川俊彦、大石智一、大庭俊一、川田学、山崎佳波、旦慎吾、堂前直、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] Furocoumarin系化合物１とDHODHの相互作用に関する研究2023
- Author(s)
  中原実玖、渡邉正悟、佐藤道大、奥村英夫、川谷誠、長田裕之、渡辺賢二
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] がん代謝阻害剤の探索と標的同定2023
- Author(s)
  川谷誠
- Organizer
  先端モデル動物支援プラットフォーム2022年度成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] がん代謝阻害剤の探索と標的同定2023
- Author(s)
  川谷誠
- Organizer
  先端モデル動物支援プラットフォーム2022年度成果発表会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05503
[Presentation] 新規DHODH阻害剤NPD723の構造活性相関解析2023
- Author(s)
  川谷誠、青野晴美、室井誠、大石智一、大庭俊一、川田学、旦慎吾、堂前直、長田裕之
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] 新規ジヒドロオロト酸脱水素酵素阻害剤の創製を目指した類縁体合成と生物活性評価2023
- Author(s)
  李梓玉、渡邉正悟、岸本真治、川谷誠、長田裕之、渡辺賢二
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] 小胞体関連ユビキチン E3 リガーゼ Gp78 と Hrd1 の阻害剤探索2023
- Author(s)
  平田規晃、川谷誠、本田香織、長田裕之、福田亮介、沖米田司
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定2022
- Author(s)
  川谷誠、青野晴美、清水猛、平沼佐代子、室井誠、小川直子、大石智一、大庭俊一、川田学、山崎佳波、旦慎吾、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定2022
- Author(s)
  川谷誠、青野晴美、室井誠、大石智一、大庭俊一、川田学、旦慎吾、長田裕之
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] ビタミンD代謝産物による脂質ベータ酸化とカルニチン生合成の制御2022
- Author(s)
  竹本靖、Mendoza Aileena、Cruzado Kevin Tana、Masoud Shadi Sedghib、永田亜希子、Tantipanjaporn Ajcharapana、奥田聡、川越文裕、坂本良太、小田木陽、本谷小佑里、冨樫萌香、川谷誠、青野晴美、長田裕之、中川勇人、東達也、橘高敦史、長澤和夫、上杉志成
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定2022
- Author(s)
  川谷誠、青野晴美、清水猛、平沼佐代子、室井誠、小川直子、大石智一、大庭俊一、川田学、山崎佳波、旦慎吾、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] がん細胞のフェロトーシスを増強するFSP1阻害剤NPD4928の発見2022
- Author(s)
  吉岡広大、河村達郎、室井誠、近藤恭光、本田香織、川谷誠、青野晴美、Herbert Waldmann、渡邉信元、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定2022
- Author(s)
  川谷誠、青野晴美、清水猛、平沼佐代子、室井誠、小川直子、大石智一、大庭俊一、川田学、山崎佳波、旦慎吾、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PLANNED-18H05503
[Presentation] ビタミンD代謝産物による脂質ベータ酸化とカルニチン生合成の制御2022
- Author(s)
  竹本靖、Mendoza Aileena、Cruzado Kevin Tana、Masoud Shadi Sedghib、永田亜希子、Tantipanjaporn Ajcharapana、奥田聡、川越文裕、坂本良太、小田木陽、本谷小佑里、冨樫萌香、川谷誠、青野晴美、長田裕之、中川勇人、東達也、橘高敦史、長澤和夫、上杉志成
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PLANNED-18H05503
[Presentation] Identification of dihydroorotate dehydrogenase inhibitors, indoluidins, that inhibit cancer cell growth2022
- Author(s)
  Makoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Kanami Yamazaki, Shingo Dan, Hiroyuki Osada
- Organizer
  11th annual conference of the International Chemical Biology Society (ICBS)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05503
[Presentation] がん細胞のフェロトーシスを増強するFSP1阻害剤NPD4928の発見2022
- Author(s)
  吉岡広大、河村達郎、室井誠、近藤恭光、本田香織、川谷誠、青野晴美、Herbert Waldmann、渡邉信元、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PLANNED-18H05503
[Presentation] Identification of dihydroorotate dehydrogenase inhibitors, indoluidins, that inhibit cancer cell growth2022
- Author(s)
  Makoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Kanami Yamazaki, Shingo Dan, Hiroyuki Osada
- Organizer
  11th annual conference of the International Chemical Biology Society (ICBS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] Identification of dihydroorotate dehydrogenase inhibitors, indoluidins, that inhibit cancer cell growth2022
- Author(s)
  Makoto Kawatani, Harumi Aono, Takeshi Shimizu, Shouta Ohkura, Sayoko Hiranuma, Makoto Muroi, Naoko Ogawa, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Kanami Yamazaki, Shingo Dan, Hiroyuki Osada
- Organizer
  11th annual conference of the International Chemical Biology Society (ICBS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] ビタミンD代謝産物による脂質ベータ酸化とカルニチン生合成の制御2022
- Author(s)
  竹本靖、Mendoza Aileena、Cruzado Kevin Tana、Masoud Shadi Sedghib、永田亜希子、Tantipanjaporn Ajcharapana、奥田聡、川越文裕、坂本良太、小田木陽、本谷小佑里、冨樫萌香、川谷誠、青野晴美、長田裕之、中川勇人、東達也、橘高敦史、長澤和夫、上杉志成
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] がん細胞のフェロトーシスを増強するFSP1阻害剤NPD4928の発見2022
- Author(s)
  吉岡広大、河村達郎、室井誠、近藤恭光、本田香織、川谷誠、青野晴美、Herbert Waldmann、渡邉信元、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-22K05363
[Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定2022
- Author(s)
  川谷誠、青野晴美、室井誠、大石智一、大庭俊一、川田学、旦慎吾、長田裕之
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PLANNED-18H05503
[Presentation] 抗腫瘍活性を有する新規DHODH阻害剤の同定2022
- Author(s)
  川谷誠、青野晴美、室井誠、大石智一、大庭俊一、川田学、旦慎吾、長田裕之
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] 2DE-CETSAを用いた抗がん活性化合物NPD971の標的同定2021
- Author(s)
  青野晴美、川谷誠、室井誠、長田裕之
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] 抗腫瘍活性を有するGLUT阻害剤glutipyranの同定2021
- Author(s)
  川谷誠、青野晴美、平沼佐代子、清水猛、室井誠、小川直子、大石智一、大庭俊一、川田学、野川俊彦、岡野亜紀子、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] GLUT阻害剤glutipyranの同定とプロテオーム解析2021
- Author(s)
  川谷誠、室井誠、長田裕之
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第8回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] がん特異的な代謝機構を阻害するRCOP8154の作用機序解析2021
- Author(s)
  林田莉奈、川谷誠、青野晴美、室井誠、二村友史、高橋俊二、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] 2DE-CETSAを用いたPKM2作用化合物NPD10084の標的同定2020
- Author(s)
  室井誠、永澤生久子、小川直子、川谷誠、大石智一、大庭俊一、川田学、長田裕之
- Organizer
  先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] 2DE-CETSAを用いた抗がん活性化合物CP10801の作用機構解析2020
- Author(s)
  青野晴美、川谷誠、室井誠、永澤生久子、二村友史、長田裕之
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] がん代謝阻害剤のスクリーニングとその分子標的同定2019
- Author(s)
  長田裕之、川谷誠
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] Analysis of metabolic switch mechanisms using GLUT1 knockout cancer cells2019
- Author(s)
  Harumi Aono, Makoto Kawatani, Naoshi Dohmae, Yushi Futamura, Makoto Muroi, and Hiroyuki Osada
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] 2次元電気泳動を用いた化合物に相互作用するたんぱく質の解析法（2DE-CETSA）の開発2019
- Author(s)
  室井誠、永澤生久子、池野あゆみ、小川直子、川谷誠、長田裕之
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] 代謝作用化合物解析に向けたChemProteoBaseの高度化2019
- Author(s)
  室井誠、二村友史、永澤生久子、川谷誠、青野晴美、小川直子、長田裕之
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第5回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] GLUT1欠損がん細胞を用いたエネルギー代謝スイッチ機構の解析2019
- Author(s)
  川谷誠、青野晴美、堂前直、二村友史、室井誠、長田裕之
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] がん細胞に活性酸素種産生を誘導する化合物RKN9055の発見と作用解析2019
- Author(s)
  河村達郎、二村友史、室井誠、川谷誠、SHANG Erchang、JANNING Petra、近藤恭光、野川俊彦、ZIEGLER Slava、渡辺信元、WALDMANN Herbert、長田裕之
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PLANNED-18H05503
[Presentation] Target identification of bioactive small molecules based on proteomic analyses using 2-D DIGE2019
- Author(s)
  Makoto Muroi, Ikuko Nagasawa, Naoko Ogawa, Harumi Aono, Yushi Futamura, Makoto Kawatani, and Hiroyuki Osada
- Organizer
  RIKEN-Max Planck Joint Research Center 7th Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05744
[Presentation] がん細胞に活性酸素種産生を誘導する化合物RKN9055の発見と作用解析2019
- Author(s)
  河村達郎、二村友史、室井誠、川谷誠、Erchang Shang、Petra Janning、近藤恭光、野川俊彦、SlavaZiegler、渡辺信元、Herbert Waldmann、長田裕之
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] 糸状菌RK17-F0007より単離したBR-050立体異性体の構造と活性評価2019
- Author(s)
  野川俊彦、川谷誠、岡野亜紀子、青野晴美、清水猛、長田裕之
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Target identification of bioactive small molecules using thermal shift assay based on 2-D electrophoresis2018
- Author(s)
  Ikuko Nagasawa, Makoto Muroi, Makoto Kawatani, and Hiroyuki Osada
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] がん代謝阻害剤スクリーニングと呼吸阻害作用解析2018
- Author(s)
  室井誠、二村友史、青野晴美、川谷誠、関根朋美、野川俊彦、林田莉奈、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] グルコース非依存性がん代謝機構を阻害するRCOP8154の作用機序解析2018
- Author(s)
  林田莉奈、川谷誠、青野晴美、二村友史、室井誠、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Exploration of small-molecule inhibitors targeting cancer metabolism2018
- Author(s)
  青野晴美、二村友史、川谷誠、室井誠、長田裕之
- Organizer
  第9回日韓ケミカルバイオロジーシンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] 2D-DIGEに基づいたCETSAによる薬剤標的分子解析システムの開発2018
- Author(s)
  永澤生久子、室井誠、川谷誠、長田裕之
- Organizer
  日本ケミカルバイオロジー学会第13回年会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Exploration of small-molecule inhibitors targeting glucose-independent cancer metabolism2018
- Author(s)
  Makoto Kawatani, Marina Hayashida, Harumi Aono, Makoto Muroi, Yushi Futamura, Hiroyuki Osada
- Organizer
  30th EORTC-NCI-AACR Symposium ‘Molecular Targets and Cancer Therapeutics’
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] プロテオミクスを用いた抗がん活性天然化合物pyrenolide Aの作用解析2018
- Author(s)
  二村友史、青野晴美、永澤生久子、河村達郎、室井誠、川谷誠、長田裕之
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] NPL40330: A novel oxidative phosphorylation inhibitor identified by bioenergetic and proteomic profiling2018
- Author(s)
  Yushi Futamura, Makoto Muroi, Harumi Aono, Makoto Kawatani, Hiroyuki Osada
- Organizer
  30th EORTC-NCI-AACR Symposium ‘Molecular Targets and Cancer Therapeutics’
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] がん代謝を阻害するプレニルフラボノイドの作用機序解析2018
- Author(s)
  二村友史、青野晴美、佐竹華子、室井誠、川谷誠、野川俊彦、井本正哉、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] がん代謝研究を加速するオミックス解析基盤の構築2018
- Author(s)
  佐竹華子、二村友史、室井誠、野川俊彦、川谷誠、井本正哉、長田裕之
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Analysis of the mechanism of action of RCOP8154 that inhibits glucose-independent cancer metabolism2018
- Author(s)
  Marina Hayashida, Makoto Kawatani, Harumi Aono, Yushi Futamura, Makoto Muroi, and Hiroyuki Osada
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] 新規薬剤標的分子解析システム2DE-CETSAの構築と応用2018
- Author(s)
  永澤生久子、室井誠、川谷誠、長田裕之
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索2017
- Author(s)
  川谷誠、青野晴美、二村友史、室井誠、長田裕之
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Screening of small-molecule inhibitors targeting glucose-independent cancer metabolism2017
- Author(s)
  Makoto Kawatani, Harumi Aono, Yushi Futamura, Makoto Muroi, and Hiroyuki Osada
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] 酸化ヌクレオチド加水分解酵素MTH1阻害剤の作用解析2016
- Author(s)
  川谷誠、河村達郎、室井誠、青野晴美、二村友史、田中美帆、長田裕之
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016
- Author(s)
  Tatsuro Kawamura, Makoto Kawatani, Makoto Muroi, Yasumitsu Kondoh, Yushi Futamura, Harumi Aono, Miho Tanaka, Kaori Honda, and Hiroyuki Osada
- Organizer
  28th EORTC-NCI-AACR International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Characterization of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival2016
- Author(s)
  河村達郎、川谷誠、室井誠、青野晴美、二村友史、長田裕之
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K01941
[Presentation] Chemical array screen identifies a novel MMP inhibitor NPDK-18 that suppresses tumor cell migration2015
- Author(s)
  Makoto Kawatani, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, and Hiroyuki Osada
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Boston, USA
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] Identification of matrix metalloproteinase inhibitors by chemical arrays2015
- Author(s)
  Makoto Kawatani, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Yoshiki Yamaguchi, Naoyuki Taniguchi, and Hiroyuki Osada
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology 4th Annual Symposium
- Place of Presentation
  神戸、ニチイ学館　神戸ポートアイランドセンター
- Year and Date
  2015-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] MorphoBaseおよびChemProteoBaseを用いたGN39482の標的同定2015
- Author(s)
  青野晴美、川谷誠、二村友史、室井誠、峯岸秀充、中村浩之、長田裕之
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山、松山全日空ホテル
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] 生理活性化合物の標的同定と創薬への試み2014
- Author(s)
  川谷誠、長田裕之
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー：分子標的と活性制御」第5回若手研究者ワークショップ
- Place of Presentation
  名古屋、名古屋大学
- Year and Date
  2014-05-29
- Invited
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] Chemical array screening for matrix metalloproteinase-9 inhibitors2013
- Author(s)
  川谷誠　他
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] Target identification of pyrrolizilactone, a new cytotoxic fungal metabolite2013
- Author(s)
  Kawatani M., et al.
- Organizer
  The second symposium - RIKEN-Max Planck Joint Research Center for Systems Chemical Biology
- Place of Presentation
  Saitama, RIKEN
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] 糸状菌由来新規抗がん活性物質pyrrolizilactoneの標的同定2013
- Author(s)
  川谷誠　他
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] Identification of a target for collismycin A, a cytotoxic microbial product, by proteomic profiling2013
- Author(s)
  Kawatani　M. et al.
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] Identification of novel tubulin polymerization inhibitors by proteomic profiling2012
- Author(s)
  Kawatani M., et al
- Organizer
  The 16th JFCR-ISCC
- Place of Presentation
  Miraikan (Tokyo)
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] 破骨細胞を標的とする小分子化合物の化学遺伝学的解析2012
- Author(s)
  川谷誠、長田裕之
- Organizer
  第153回日本獣医学会学術集会
- Place of Presentation
  大宮ソニックシティ(大宮)(招待講演)
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of novel tubulin polymerization inhibitors by proteomic profiling2012
- Author(s)
  Makoto Kawatani, Makoto Muroi, and Hiroyuki Osada
- Organizer
  The 16th JFCR-ISCC
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Chemical biology studies on inhibitors of cancer bone metastases2012
- Author(s)
  川谷誠
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Proteome- and cell morphology-based target identification for RKB3564F070, a new cytotoxic fungal metabolite2012
- Author(s)
  Makoto Kawatani, Harumi Aono, Toshihiko Nogawa, Makoto Muroi, Yushi Futamura, and Hiroyuki Osada
- Organizer
  The 1st official conference of the international chemical biology society
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] 破骨細胞を標的とする小分子化合物の化学遺伝学的解析2012
- Author(s)
  川谷誠、長田裕之
- Organizer
  第153回日本獣医学会学術集会
- Place of Presentation
  大宮
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of a molecular target for RKB3564F070, a new cytotoxic fungal metabolite2012
- Author(s)
  川谷誠、青野晴美、室井誠、二村友史、長田裕之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] プロテオームプロファイリングによるチューブリン重合阻害剤の同定2011
- Author(s)
  川谷誠, ら
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of novel tubulin polymerization inhibitors by proteomic profiling2011
- Author(s)
  Kawatani M., et al
- Organizer
  AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  Moscone Center West (San Francisco)
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] プロテオームプロファイリングによるチューブリン重合阻害剤の同定2011
- Author(s)
  川谷誠、富田康司、風見紗弥香、青野晴美、室井誠、清水猛、長田裕之
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] プロテオームプロファイリングによるチューブリン重合阻害剤の同定2011
- Author(s)
  川谷誠、青野晴美、室井誠、長田裕之
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Identification of novel tubulin polymerization inhibitors by proteomic profiling2011
- Author(s)
  Makoto Kawatani, Kouji Tomita, Makoto Muroi, Sayaka Kazami, Harumi Aono, Takeshi Shimizu, and Hiroyuki Osada
- Organizer
  AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2010
- Author(s)
  Makoto Kawatani, and Hiroyuki Osada
- Organizer
  2010 RIKEN Chemical Biology International Symposium
- Place of Presentation
  Saitama, Japan
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] 細胞質空胞化を誘導するNPD1801 の作用機構解析2010
- Author(s)
  川谷誠、風見紗弥香、青野晴美、早川洋一、長田裕之
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2010
- Author(s)
  Kawatani, M., et al.
- Organizer
  2010 RIKEN Chemical Biology International Symposium
- Place of Presentation
  埼玉
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] 細胞質空胞化を誘導するNPD1801 の作用機作解析2010
- Author(s)
  川谷誠、青野晴美、早川洋一、長田裕之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] 細胞質空胞化を誘導するNPD1801の作用機構解析2010
- Author(s)
  川谷誠, ら
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Antitumor activity of NPD723, a novel potent cell differentiation-inducing agent in leukemic cells2010
- Author(s)
  Makoto Kawatani, Harumi Aono, and Hiroyuki Osada
- Organizer
  22nd AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Antitumor activity of NPD723, a novel potent cell differentiation-inducing agent in leukemic cells2010
- Author(s)
  Kawatani, M., et al.
- Organizer
  22nd AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  Berlin
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] 細胞質空胞化を誘導するNPD1801の作用機作解析2010
- Author(s)
  川谷誠, ら
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22681034
[Presentation] Methyl gerfelin, a small molecule inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2009
- Author(s)
  川谷誠 et al.
- Organizer
  The 26^<th> Naito Conference-Osteobiology-
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] Identification of a novel DNA topoisomerase II inhibitor by proteomic profiling2009
- Author(s)
  川谷誠 et al.
- Organizer
  AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] Methyl gerfelin, a small molecule inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2009
- Author(s)
  川谷誠
- Organizer
  The 26th Naito Conference-Osteobiology-
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] Identification of a novel DNA topoisomerase II inhibitor by proteomic profiling2009
- Author(s)
  川谷誠
- Organizer
  AACR-NCI-EORTC International Conference "Molecular Targets and Cancer Therapeutics"
- Place of Presentation
  ボストン
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] 分化誘導活性物質NPD723の作用機構解析2009
- Author(s)
  川谷誠
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] GUT-70、並びに、誘導体BNS-22のプロテオミクスを用いた作用標的解析2008
- Author(s)
  室井誠, 風見紗弥香, 高山浩, 川谷誠, 木村晋也, 前川平, 長田裕之
- Organizer
  第12回がん分子標的治療研究会
- Place of Presentation
  東京都千代田区学術総合センター
- Data Source
  KAKENHI-PROJECT-19658047
[Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2008
- Author(s)
  川谷誠, 他
- Organizer
  第4回日韓合同シンポジウム
- Place of Presentation
  日光
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] Screening and target identification of bioprobes2008
- Author(s)
  川谷誠
- Organizer
  第1回理研ケミカルバイオロジー研究領域国際シンポジウム
- Place of Presentation
  熱海
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] 抗腫瘍活性物質GUT-70の作用機構解析2008
- Author(s)
  川谷誠
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] 抗腫瘍活性物質BNS-22はDNA topoisomerase II活性を阻害する2008
- Author(s)
  川谷誠
- Organizer
  日本ケミカルバイオロジー研究会第3回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2008
- Author(s)
  川谷誠
- Organizer
  第4回日韓合同シンポジウム
- Place of Presentation
  日光
- Data Source
  KAKENHI-PROJECT-20710175
[Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2007
- Author(s)
  Kawatani M., et. al.
- Organizer
  AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics
- Place of Presentation
  San Francisco
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-18710193
[Presentation] Target identification of collismycin A, a cytotoxic microbial product, by proteomic profiling
- Author(s)
  川谷誠、室井誠、二村友史、青野晴美、長田裕之
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] 多面的アプローチによる生理活性化合物の標的同定
- Author(s)
  川谷誠、長田裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸、神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] ChemProteoBaseを用いたcollismycin Aの作用標的同定
- Author(s)
  川谷誠、室井誠、二村友史、青野晴美、長田裕之
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台、ホテルメトロポリタン仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] 癌骨転移抑制剤のケミカルバイオロジー研究
- Author(s)
  川谷誠、長田裕之
- Organizer
  第16回癌と骨病変研究会
- Place of Presentation
  東京、千代田放送会館
- Invited
- Data Source
  KAKENHI-PROJECT-25350981
[Presentation] Target identification of collismycin A, a cytotoxic microbial product, by proteomic profiling
- Author(s)
  Makoto Kawatani, Gyo Inoue, Makoto Muroi, Yushi Futamura, Harumi Aono, and Hiroyuki Osada
- Organizer
  RIKEN-Max Planck Joint Research Center for Systems Chemical Biology 3rd Annual Symposium
- Place of Presentation
  Munich, Germany
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25350981

1. MUROI Makoto (30261168)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
2. UCHIDA Takafumi (80312239)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KIYOTA Hiromasa (30234397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. USUI Takeo (60281648)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FUTAMURA Yushi (70525857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
6. OKUMURA Hideo (90377903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IZUMI Minoru (90379719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yoshida Minoru (80191617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. PRADIPTA AMBARA (90631648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 近藤恭光 (80333342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. KAZAMI Sayaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. HONDA Kaori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIMIZU Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HIRANUMA Sayoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. WIERZBA Konstanty

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHI Qinq-Wen

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Hayashida Marina

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. Nogawa Toshihiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
19. TAKAHASHI Shunji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. KANOH Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. TABUCHI Masako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 安部正博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 長田裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
24. 梅沢一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 宮沢健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 篠原正浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 上杉志成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 竹本靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 本山高幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 大石智一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWATANI Makoto 川谷 誠

川谷 誠 カワタニ マコト

Research Projects

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Co-Researchers

小分子化合物によるグルコース非依存性がん代謝機構の理解と制御Principal Investigator

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Development of small-molecule inhibitors targeting the metabolic switch in cancer cellsPrincipal Investigator

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Chemical biology for controlling ubiquitin function

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Review Section

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Development of small-molecule inhibitors targeting glucose-independent cancer metabolismPrincipal Investigator

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Development of novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathwayPrincipal Investigator

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Development of agrochemical and pharmaceutical lead compounds based on the search and total synthesis of natural compounds with a unique structure and biological activity

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Total synthesis and investigation of biologically active natural compounds with novel and complex structures and its application to the development of agricultural and pharmaceutical lead compounds

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Development of anti-cancer agents targeting the endocytic pathwayPrincipal Investigator

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Development of a novel anticancer drug targeting UBL-UBA family proteinPrincipal Investigator

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プロテオミックス的手法を用いた薬剤作用解析システムの構築

Principal Investigator

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癌骨転移に対する分子標的治療薬の開発Principal Investigator

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[Book] 細胞骨格系、分子標的薬 －がんから他疾患までの治癒をめざして－2012

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Publisher

Data Source

[Book] 「細胞骨格系」日本臨床(増刊号)2012

Author(s)

Data Source

[Journal Article] Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling2023

Author(s)

KAWATANI Makoto 川谷誠

川谷誠カワタニマコト

[Book] 細胞骨格系、分子標的薬　－がんから他疾患までの治癒をめざして－2012