Iwai Miwako 岩井美和子

… Alternative Names

岩井美和子イワイミワコ

IWAI Miwako 岩井美和子

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Researcher Number	50396884
Affiliation (Current)	2025: 東京大学, 医科学研究所, 技術専門員
Affiliation (based on the past Project Information) *help	2023: 東京大学, 医科学研究所, 技術専門員 2021: 東京大学, 医科学研究所, 技術専門員 2014 – 2020: 東京大学, 医科学研究所, 技術専門職員 2008 – 2011: The University of Tokyo, 医科学研究所, 技術専門職員
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 50020:Tumor diagnostics and therapeutics-related / Clinical oncology / Human pathology
Keywords	Principal Investigator ウイルス療法 / 抗腫瘍免疫 / 単純ヘルペスウイルスI型 / スプライシング・バリアント / CADM1 / 細胞接着分子 / 小細胞肺癌 / ネオアジュバント / 遺伝子治療 / がん幹細胞 … More / 脳腫瘍 / 癌転移 / 小細胞 / スプライシングバリアント・癌転移 / 小細胞肺癌・細胞接着因子・CADM1 / TSLCl / TSLC1/CADM1 / スプライシングバリアント / TSLC1 / 分子病理 Less

がん根治を目指したネオアジュバントウイルス療法の基礎研究Principal Investigator
- Principal Investigator
  
  岩井美和子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
Fundamental research on oncolytic viral therapy strategies with enhanced antitumor immune activityPrincipal Investigator
- Principal Investigator
  
  IWAI Miwako
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  The University of Tokyo
Basic research on novel oncolytic virus therapy targeting glioma initiating cellsPrincipal Investigator
- Principal Investigator
  
  IWAI Miwako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  The University of Tokyo
Approach for prevention of metastasis of small cell lung cancer by targeting a specific splicing isoform of CADM1Principal Investigator
- Principal Investigator
  
  IWAI Miwako
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Clinical oncology
- Research Institution
  The University of Tokyo
The role of a small cell lung cancer -specific alternative splice variant of TSLC1 in metastasis.Principal Investigator
- Principal Investigator
  
  IWAI Miwako
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  The University of Tokyo

All 2023 2021 2020 2019 2018 2017 2016 2014 2012 2011

All Journal Article Presentation

[Journal Article] Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma2021
- Author(s)
  Yajima Shoh、Sugawara Kotaro、Iwai Miwako、Tanaka Minoru、Seto Yasuyuki、Todo Tomoki
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 23 Pages: 402-411
- DOI
  10.1016/j.omto.2021.10.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07213
[Journal Article] Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation2021
- Author(s)
  Sugawara Kotaro、Iwai Miwako、Ito Hirotaka、Tanaka Minoru、Seto Yasuyuki、Todo Tomoki
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 22 Pages: 129-142
- DOI
  10.1016/j.omto.2021.05.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07213
[Journal Article] Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis2021
- Author(s)
  Uchihashi Toshihiro、Nakahara Hirokazu、Fukuhara Hiroshi、Iwai Miwako、Ito Hirotaka、Sugauchi Akinari、Tanaka Minoru、Kogo Mikihiko、Todo Tomoki
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 22 Pages: 388-398
- DOI
  10.1016/j.omto.2021.06.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07213, KAKENHI-PROJECT-19K10321, KAKENHI-PROJECT-21K10137, KAKENHI-PROJECT-19K09720
[Journal Article] Neoadjuvant use of oncolytic herpes virus G47Δ enhances the antitumor efficacy of radiofrequency ablation.2020
- Author(s)
  Yamada T, Tateishi R, Iwai M, Koike K, Todo T
- Journal Title
  
  Mol Ther Oncolytics
  
  Volume: 18 Pages: 535-545
- DOI
  10.1016/j.omto.2020.08.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07213, KAKENHI-PROJECT-20K08352
[Journal Article] Efficacy of a third-generation oncolytic herpes virus G47Δ in advanced stage models of human gastric cancer.2020
- Author(s)
  Sugawara K, Iwai M, Yajima S, Tanaka M, Yanagihara K, Seto Y, Todo T
- Journal Title
  
  Mol Ther Oncolytics
  
  Volume: 17 Pages: 205-215
- DOI
  10.1016/j.omto.2020.03.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07213
[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012
- Author(s)
  Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Masuda T, Tsuda H, Kanai Y, Onizuka M, Sato Y, and Murakami Y
- Journal Title
  
  Cancer Science
  
  Volume: (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700914
[Journal Article] Aberrant expression of tumor suppressors, CADM1 and 4. IB, in invasive lesions of primary breast cancer2012
- Author(s)
  Takahashl Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y
- Journal Title
  
  Breast Cancer
  
  Volume: (掲載確定) Issue: 3 Pages: 242-252
- DOI
  10.1007/s12282-011-0272-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05125, KAKENHI-PROJECT-22300336, KAKENHI-PROJECT-22700914
[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012
- Author(s)
  Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, 0nizuka M, Sato Y, Murakami Y
- Journal Title
  
  Cancer Science
  
  Volume: 103 Issue: 6 Pages: 1051-1057
- DOI
  10.1111/j.1349-7006.2012.02277.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05125, KAKENHI-PROJECT-21790309, KAKENHI-PROJECT-22300336, KAKENHI-PROJECT-22700914, KAKENHI-PROJECT-23790391, KAKENHI-PROJECT-24790310, KAKENHI-PROJECT-24790802
[Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells2011
- Author(s)
  Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, Murakami Y
- Journal Title
  
  Genes to Cells
  
  Volume: 16 Issue: 7 Pages: 791-802
- DOI
  10.1111/j.1365-2443.2011.01525.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05125, KAKENHI-PROJECT-22700914, KAKENHI-PROJECT-23790391
[Journal Article] 頭頸部癌におけるTP53・EGFR遺伝子異常の解析2011
- Author(s)
  蝦原康宏、岩井美和子、吉田昌史、安藤瑞生、朝蔭孝宏、山岨達也、村上善則
- Journal Title
  
  頭頸部癌 37(1)
  
  Pages: 1-6
- NAID
  10030814670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790276
[Journal Article] Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer.2011
- Author(s)
  Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y.
- Journal Title
  
  Breast Cancer [Epub ahead of print]
- NAID
  10031170651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790276
[Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells.2011
- Author(s)
  Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, Murakami Y.
- Journal Title
  
  Genes to Cells 掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790276
[Presentation] 免疫チェックポイント阻害抗体発現型抗がんヘルペスウイルスの開発2023
- Author(s)
  岩井美和子、藤堂具紀
- Organizer
  第1回日本ウイルス療法学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06691
[Presentation] 可溶性 B7-1 発現型がん治療用 HSV-1 のマウス舌癌頸部リンパ節転移巣に対する治療効果2021
- Author(s)
  内橋俊大、須河内昭成、栗岡恭子、笠原駿、伊藤博崇、岩井美和子、田中実、田中晋、古郷幹彦、藤堂具紀
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] 腫瘍溶解性ウイルス G47Δ を術前療法として用いることで、舌癌の進行を抑制する2021
- Author(s)
  井上公介、伊藤博崇、岩井美和子、森良之、藤堂具紀
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] がん治療用ヘルペスウイルスG47Δと抗CTLA-4抗体の併用による食道扁平上皮癌に対する新規治療戦略2020
- Author(s)
  菅原弘太朗、岩井美和子、瀬戸泰之、藤堂具紀
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] マウス舌がんモデルにおけるB7-1発現型第三世代がん治療用単純ヘルペスウイルスI型の治療効果と安全性2020
- Author(s)
  笠原駿, 内橋俊大, 須河内昭成, 栗岡恭子、田中晋、岩井美和子, 古郷幹彦, 藤堂具紀
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] Preclinical safety studies of an oncolytic herpes simplex virus type I armed with interleukin-12.2019
- Author(s)
  岩井美和子、福原浩、田中実、藤堂具紀
- Organizer
  第25回日本遺伝子治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] 免疫修飾機能を付加した新規がん治療用単純ヘルペスウイルスI型の非臨床評価2018
- Author(s)
  鈴木沙依, 稲生靖, 岩井美和子, 福原浩, 藤堂具紀
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] Therapeutic efficacy of oncolytic herpes simplex virus type 1 expressing an immunomodulatory molecule in mouse neuroblastoma and melanoma models2018
- Author(s)
  鈴木沙依, 稲生靖, 岩井美和子, 福原浩, 藤堂具紀
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] Therapeutic efficacy of oncolytic herpes simplex virus type 1 armed with an immunomodulatory molecule in murine tumor models2018
- Author(s)
  鈴木沙依, 稲生靖, 岩井美和子, 福原浩, 藤堂具紀
- Organizer
  第18回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] Development of oncolytic virus therapy with armed oncolytic herpes simplex virus type 1 for the treatment of malignant melanoma2018
- Author(s)
  鈴木沙依, 稲生靖, 岩井美和子, 福原浩, 藤堂具紀
- Organizer
  若手支援技術講習会 2018
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] IL-12発現型がん治療用ヘルペスウイルスの非臨床安全性および体内分布評価2017
- Author(s)
  岩井美和子、稲生靖、福原浩、藤堂具紀
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07213
[Presentation] 脳腫瘍幹細胞を標的としたBMP4発現型HSV-1の治療効果2016
- Author(s)
  岩井美和子
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-26430156
[Presentation] がん幹細胞が豊富な腫瘍に対するTGF-β阻害分子発現型HSV-1の治療効果2014
- Author(s)
  岩井美和子
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市西区みなとみらい）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26430156
[Presentation] 乳がんの進展、再発に関わる細胞接着因子CADM1、並びに新規分子標的の解析2011
- Author(s)
  村上善則、高橋由佳、岩井美和子、荒川敦、伊東剛、櫻井美佳、伊藤彰彦、後藤明輝、伊東紀子、江見充、齋藤光江、霞富士雄
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700914
[Presentation] Dual roles of a cell adhesion molecule, CADM1/TSLC, in oncogenesis2011
- Author(s)
  村上善則、永田政義、櫻井美佳、川合剛人、坪井裕見、岩井美和子、増田真里、後藤明輝
- Organizer
  The 3rd CREST-SBM International Conference : Mathematical Methods in Cancer Cell Biology
- Place of Presentation
  広島大学
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-22700914
[Presentation] 膀胱癌における細胞接着分子CADM1、およびCADM4の異常2011
- Author(s)
  川合剛人,後藤明輝、岩井美和子、永田政義、森川鉄平、久米春喜、深山正久、本間之夫、村上善則
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22700914

1. TODO Tomoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. INO Yasushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MIYAZONO Kohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. WATABE Tetsuro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Iwai Miwako 岩井 美和子

岩井 美和子 イワイ ミワコ

IWAI Miwako 岩井 美和子

Research Projects

Research Products

Co-Researchers

がん根治を目指したネオアジュバントウイルス療法の基礎研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental research on oncolytic viral therapy strategies with enhanced antitumor immune activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic research on novel oncolytic virus therapy targeting glioma initiating cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Approach for prevention of metastasis of small cell lung cancer by targeting a specific splicing isoform of CADM1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of a small cell lung cancer -specific alternative splice variant of TSLC1 in metastasis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neoadjuvant use of oncolytic herpes virus G47Δ enhances the antitumor efficacy of radiofrequency ablation.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of a third-generation oncolytic herpes virus G47Δ in advanced stage models of human gastric cancer.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012

Author(s)

Journal Title

Data Source

[Journal Article] Aberrant expression of tumor suppressors, CADM1 and 4. IB, in invasive lesions of primary breast cancer2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells2011

Author(s)

Journal Title

DOI

Data Source

Iwai Miwako 岩井美和子

岩井美和子イワイミワコ

IWAI Miwako 岩井美和子

[Presentation] 可溶性 B7-1 発現型がん治療用 HSV-1 のマウス舌癌頸部リンパ節転移巣に対する治療効果2021

[Presentation] 腫瘍溶解性ウイルス G47Δ を術前療法として用いることで、舌癌の進行を抑制する2021