OKUMARU Sho 徳丸晶

… Alternative Names

徳丸晶トクマルショウ

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Researcher Number	50398046
Other IDs
Affiliation (based on the past Project Information) *help	2012: 愛媛大学, 大学院・医学系研究科, 講師 2008 – 2011: 愛媛大学, 医学部附属病院, 講師 2006: 愛媛大学, 医学部附属病院, 講師 2005: 愛媛大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Dermatology Except Principal Investigator Dermatology
Keywords	Principal Investigator 表皮角化細胞 / シグナル伝達 / catestatin / 抗菌ペプチド / Transactivation / EGF受容体 / 細胞遊走 / エンドセリン Except Principal Investigator K5-Cre / LC … More / 分化 / ノックアウトマウス / 角化細胞 / Atg5 / オートファジー / 自然免疫 / 角化細 / 皮膚感染症 / マウス / NF-кB / 臨床研究 / 再生 / 皮膚 / TAK1 / マウスモデル / 毛周期 / NF-kB / βグルカン / 円形脱毛症 / マイクロアレイ / 爪 / 幹細胞 / 細胞・組織 / 再生医学 Less

Role of Atg5-dependent autophagy in innate immunity of epidermal keratinocytes
- Principal Investigator
  
  SAYAMA Koji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Ehime University
抗菌ペプチドCATESTATINによる表皮角化細胞遊走誘導制御機構の解析Principal Investigator
- Principal Investigator
  
  徳丸晶
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Ehime University
超微粒子化βグルカンによるNF-κB活性化を応用した円形脱毛症の新規治療法の開発
- Principal Investigator
  
  SAYAMA Koji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Ehime University
表皮幹細胞を用いた爪の再生に関する研究
- Principal Investigator
  
  SHIRAKATA Yuji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Ehime University
エンドセリン-1による表皮細胞遊走機構の研究Principal Investigator
- Principal Investigator
  
  徳丸晶
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Ehime University

All 2011 2010 2009 2007 2006 2005

All Journal Article Presentation

[Journal Article] Mite allergen is a danger signal for the skin via activation of inflamasome in keratinocytes2011
- Author(s)
  Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, and Hashimoto K.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 127 Issue: 3 Pages: 806-814
- DOI
  10.1016/j.jaci.2010.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390218
[Journal Article] Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation2011
- Author(s)
  Okazaki H, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 412 Issue: 3 Pages: 441-5
- DOI
  10.1016/j.bbrc.2011.07.111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591434, KAKENHI-PROJECT-22390218
[Journal Article] E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity2010
- Author(s)
  Sayama K, Tokumaru S, et al.
- Journal Title
  
  Journal of biological Chemistry
  
  Volume: 285 Pages: 30042-30049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591465
[Journal Article] Auto-and cross induction by beta cellulin in epidermal keratinocytes2010
- Author(s)
  Shirakata Y, Tokumaru S, et al.
- Journal Title
  
  Jouranl of Dermatological Science
  
  Volume: 58 Pages: 162-164
- NAID
  10027400978
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591465
[Journal Article] E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity2010
- Author(s)
  Sayama K, Yamamoto M, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, and Hashimoto K.
- Journal Title
  
  J Biol Chem;
  
  Volume: 285 Issue: 39 Pages: 30042-30049
- DOI
  10.1074/jbc.m110.106484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390218
[Journal Article] PPARγ mediates innate immunity by regulating the 1α,25-dyhydroxy vitaminD3 induced hBD-3 and cathelicidin in human keratinocyte2010
- Author(s)
  Dai X, Tokumaru S, et al.
- Journal Title
  
  Jouranl of Dermatological Science
  
  Volume: 60 Pages: 179-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591465
[Journal Article] PPARγmediates innate immunity by regulating the 1α, 25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes2010
- Author(s)
  Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, and Hashimoto K.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 60 Issue: 3 Pages: 179-186
- DOI
  10.1016/j.jdermsci.2010.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390218
[Journal Article] IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-222009
- Author(s)
  Tohyama M, Tokumaru S, et al.
- Journal Title
  
  Eur J Immunol 39
  
  Pages: 2779-2788
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591465
[Journal Article] Living skin equivalents constructed using human amnions as a matrix2009
- Author(s)
  Yang L, Tokumaru S, et al.
- Journal Title
  
  J Dermatol Sci 56
  
  Pages: 188-195
- NAID
  10027398843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591465
[Journal Article] Nodal lymphangiogenesis and metastasis : Role of tumor-induoed lymphatic vessel activation in extramammary Paget's disease2009
- Author(s)
  Hirakawa S, Tokumaru S, et al.
- Journal Title
  
  Am J Pathol 175
  
  Pages: 2235-2248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591465
[Journal Article] Epiregulin, a member of the EGF family, is over-expressed in psoriatic epidermis.2007
- Author(s)
  Shirakata Y, Kishimoto J, Tokumaru S, Yamasaki K, Hanakawa Y, Tohyama M, Sayama K, Hashimoto K
- Journal Title
  
  J Dermatol Sci. 45(1)
  
  Pages: 69-72
- NAID
  10019994988
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis.2006
- Author(s)
  Sayama K, Hanakawa Y, Nagai H, Shirakata Y, Dai X, Hirakawa S, Tokumaru S, Tohyama M, Yang L, Sato S, Shizuo A, Hashimoto K
- Journal Title
  
  J Biol Chem. 281(31)
  
  Pages: 22013-22020
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation.2006
- Author(s)
  Yahata Y, Shirakata Y, Tokumaru S, Yang L, Dai X, Tohyama M, Tsuda T, Sayama K, Iwai M, Horiuchi M, Hashimoto K
- Journal Title
  
  J Biol Chem. 281(19)
  
  Pages: 13209-13216
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] SOCS1 negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes.2006
- Author(s)
  Dai X, Tokumaru S, et al.
- Journal Title
  
  The Journal of Investigative Dermatology (In press)
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes.2006
- Author(s)
  Yang L, Tokumaru S, et al.
- Journal Title
  
  The Journal of Dermatological Science (In press)
- NAID
  10020549817
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes.2006
- Author(s)
  Dai X, Sayama K, Yamasaki K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yahata Y, Yang L, Yoshimura A, Hashimoto K
- Journal Title
  
  J Invest Dermatol. 126(7)
  
  Pages: 1574-1581
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes.2006
- Author(s)
  Yang L, Yamasaki K, Shirakata Y, Dai X, Tokumaru S, Yahata Y, Tohyama M, Hanakawa Y, Sayama K, Hashimoto K
- Journal Title
  
  J Dermatol Sci. 42(2)
  
  Pages: 111-119
- NAID
  10020549817
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] New skin-equivalent model from de-epithelialized amnion membrane.2006
- Author(s)
  Yang L, Shirakata Y, Shudou M, Dai X, Tokumaru S, Hirakawa S, Sayama K, Hamuro J, Hashimoto K
- Journal Title
  
  Cell Tissue Res. 326(1)
  
  Pages: 69-77
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] Induction of keratinocyte migration via transactivation of the EGF receptor by the antimicrobial peptide LL-37.2005
- Author(s)
  Tokumaru S, Sayama K, Shirakata Y, et al.
- Journal Title
  
  Journal of Immunology 175
  
  Pages: 4662-4668
- Data Source
  KAKENHI-PROJECT-17659342
[Journal Article] dsRNA-mediated innate immunity of epidermal keratinocytes.2005
- Author(s)
  Tohyama M, Tokumaru S, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 335
  
  Pages: 505-511
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] Microbubble-enhanced ultrasound for gene transfer into living skin equivalents.2005
- Author(s)
  Yang L, Tokumaru S, et al.
- Journal Title
  
  The Journal of Dermatological Science 40
  
  Pages: 105-114
- NAID
  10018032379
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing2005
- Author(s)
  Shirakata Y, Tokumaru S, et al.
- Journal Title
  
  The Journal of Cell Science 118
  
  Pages: 2363-2370
- Data Source
  KAKENHI-PROJECT-17790772
[Journal Article] Induction of keratinocyte migration via transactivation of the EGF receptor by the antimicrobial peptide LL-37.2005
- Author(s)
  Tokumaru S, Sayama K, et al.
- Journal Title
  
  Journal of Immunology 175
  
  Pages: 4662-4668
- Data Source
  KAKENHI-PROJECT-17790772
[Presentation] Mite allergen activates inflammasome in epidermal keratinocytes resulting in the production of IL-1beta and IL-182011
- Author(s)
  Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, and Hashimoto K
- Organizer
  22ndWorld Congress of Dermatology
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-22390218
[Presentation] A new cutaneous antimicrobial peptide catestatin-induced keratinocyte migration is regulated by PI3K, Rac and Rho signaling pathway2010
- Author(s)
  Tokumaru S, et al.
- Organizer
  日本研究皮膚科学会第35回年次学術大会・総会
- Place of Presentation
  和歌山
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21591465

1. SHIRAKATA Yuji (50226320)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. SAYAMA Koji (80187286)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. HANAKAWA Yasushi (90284398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 亀田健治 (60363264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 村上信司 (50175626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKUMARU Sho 徳丸 晶

徳丸 晶 トクマル ショウ

Research Projects

Research Products

Co-Researchers

Role of Atg5-dependent autophagy in innate immunity of epidermal keratinocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗菌ペプチドCATESTATINによる表皮角化細胞遊走誘導制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

超微粒子化βグルカンによるNF-κB活性化を応用した円形脱毛症の新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

表皮幹細胞を用いた爪の再生に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エンドセリン-1による表皮細胞遊走機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mite allergen is a danger signal for the skin via activation of inflamasome in keratinocytes2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity2010

Author(s)

Journal Title

Data Source

[Journal Article] Auto-and cross induction by beta cellulin in epidermal keratinocytes2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PPARγ mediates innate immunity by regulating the 1α,25-dyhydroxy vitaminD3 induced hBD-3 and cathelicidin in human keratinocyte2010

Author(s)

Journal Title

Data Source

[Journal Article] PPARγmediates innate immunity by regulating the 1α, 25-dihydroxyvitamin D3 induced hBD-3 and cathelicidin in human keratinocytes2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-222009

Author(s)

Journal Title

Data Source

[Journal Article] Living skin equivalents constructed using human amnions as a matrix2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Nodal lymphangiogenesis and metastasis : Role of tumor-induoed lymphatic vessel activation in extramammary Paget's disease2009

Author(s)

Journal Title

OKUMARU Sho 徳丸晶

徳丸晶トクマルショウ