TSURUZOE Kaku 水流添覚

Researcher Number	50398202
Other IDs
Affiliation (based on the past Project Information) *help	2010: 熊本大学, 医学部附属病院, 講師 2009: 熊本大学, 医学部・付属病院, 助教 2008: Kumamoto University, 医学部・附属病院, 助教 2007 – 2008: Kumamoto University, University Hospital, Assistant Professor 2005 – 2006: 熊本大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics / Biomedical engineering/Biological material science / Biological Sciences
Keywords	Principal Investigator CaM kinase II / insulin secretion / pancreatic beta cell / CaMキナーゼII / インスリン分泌 / 膵β細胞 / 脂肪組織 / 糖尿病合併症 / インスリン抵抗性 / MnSOD … More / 酸化ストレス / 脂肪 / 糖尿病 / 糖尿病学 … More Except Principal Investigator Rho-kinase / Y-27632 / MIN6 / 膵β細胞 / Hsp72 / 糖尿病 / インスリン抵抗性 / promoter / pancreatic β-cell / insulin gene / プロモーター / インスリン遺伝子 / Rho-Kinase / 小胞体ストレス / インスリン分泌 / HSP72 / 温熱電流同時印加療法 / 内臓脂肪 / 微弱電流 / 温熱 / Polymide / 超小型針型ブドウ糖センサ / ポリイミド / 超小型ブドウ糖センサ / 携帯型人工膵島 / AICAR / マクロファージ / インスリン受容体 / IRS-1 / インスリン / 脂肪細胞 Less

Identification of novel molecules associated with insulin action or insulin secretion induced by mild electric current and hyperthermia therapy
- Principal Investigator
  
  KONDO Tatsuya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
The molecular mechanisms of improvement of insulin resistance and reduction of visceral fat by combination of mild electrical current and thermo therapy
- Principal Investigator
  
  KONDO Tatsuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Role of reactive oxygen species in white and brown adipose tissuesin pathogenesis of insulin resistancePrincipal Investigator
- Principal Investigator
  
  TSURUZOE Kaku
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Regulation of insulin gene expression by small G protein related protein, Rho-kinase.
- Principal Investigator
  
  FURUKAWA Noboru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
ポリイミドを用いた易操作性超小型ブドウ糖センサの開発
- Principal Investigator
  
  下田誠也
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kumamoto University
Regulation of pancreatic・cell function by Ca2+/calmodulin-dependent protein kinase II delta.-Analysis using CaM-KIIN, noble inhibitory protein, and constitutive active CaM kinase II-Principal Investigator
- Principal Investigator
  
  TSURUZOE Kaku
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY
脂肪細胞におけるインスリン作用伝達分子の発現調節と生体機能制御における意義
- Principal Investigator
  
  ARAKI Eiichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University

All 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] A case of ectopic adrenocorticotropic hormoneproducing pancreatic neuroendocrine tumor with multiple liver metastases2010
- Author(s)
  Kondo, T., Matsuyama, R., Ashihara, H., Matsuo, Y., Sasaki, K., Goto, R., Ono, K., T akaki, Y., Honda, Y., Iyama, K., Kawashima, J., Motoshima, H., Tsuruzoe, K., Miyamura, N. and Araki, E
- Journal Title
  
  Endocrine J
  
  Volume: 57(3) Pages: 229-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] Heat Shock Treatment with Mild Electrical Stimulation Safely Reduced Inflammatory Markers in Healthy Male Subjects2010
- Author(s)
  Kondo, T., Sasaki, K., Adachi, H., Nakayama, Y., Hatemura, M., Matsuyama, R., Tsuruzoe, K., Furukawa, N., Motoshima, H., Morino, S., Yamashita, Y., Miyamura, N., Kai, H., Araki, E.
- Journal Title
  
  Obesity Research and Clinical Practice (In press)
- NAID
  120003184552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010
- Author(s)
  Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 29(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010
- Author(s)
  Hironori Adachi, Tatsuya Kondo, K. Tsuruzoe, H Motoshima, E Araki, et al
- Journal Title
  
  American Journal of Physiology.Endocrinology and Metabolism.
  
  Volume: 29(5) Pages: 764-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] Angptl 4 deficiencyimproves lipid metabolism, suppresses foamcell formation and protects against atherosclerosis2009
- Author(s)
  Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E.
- Journal Title
  
  Biochem Biophys Res Commun 379
  
  Pages: 806-811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591059
[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009
- Author(s)
  Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa. N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 379(4)
  
  Pages: 806-11
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] Oxidized low density lipoprotein activatesperoxisome proliferator-activatedreceptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages2008
- Author(s)
  Taketa K, Matsumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T, Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E.
- Journal Title
  
  J Biol Chem 283
  
  Pages: 9852-98621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591059
[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetes mice2008
- Author(s)
  Goto H, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E.
- Journal Title
  
  Biochem Biophys Res Commun 366
  
  Pages: 814-820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591059
[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008
- Author(s)
  Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.
- Journal Title
  
  Biochem Biophys Res Commun 376(2)
  
  Pages: 434-8
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008
- Author(s)
  Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.
- Journal Title
  
  Biochem Biophys Res Commun 376
  
  Pages: 434-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591059
[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice2008
- Author(s)
  Goto H, Nishikawa T, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 366(3)
  
  Pages: 814-20
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance2007
- Author(s)
  Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 364(2)
  
  Pages: 301-7
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance2007
- Author(s)
  Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, IgataM, Taketa K, Sasaki K, Kishikawa H, KahnCR, Toyonaga T, Araki E.
- Journal Title
  
  Biochem Biophys Res Commun 364
  
  Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591059
[Journal Article] Impact of mitochondria! reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin2006
- Author(s)
  Imoto K, Kukidome D, Nishikawa T, Matsuhisa T, Sonoda K, Fujisawa K, Yano M, Motoshima H, Taguchi T, Tsuruzoe K, Matsumura T, Ichijo H, Araki E.
- Journal Title
  
  Diabetes. 55
  
  Pages: 1197-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590942
[Journal Article] A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy.2006
- Author(s)
  Matsuyoshi, A., Shimoda, S., Tsuruzoe, K., Taketa, K., Chirioka, T., Sakamoto, F., Sakakida, M., Miyamura, N., Araki, E.
- Journal Title
  
  Diabet Res Clin Pract. 72
  
  Pages: 238-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590942
[Journal Article] Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice.2005
- Author(s)
  Kodama S, Toyonaga T, Kondo T, Matsumoto K, Tsuruzoe K, Kawashima J, Goto H, Kume K, Kume S, Sakakida M, Araki E.
- Journal Title
  
  Biochem Biophys Res Commun 327
  
  Pages: 1170-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590942
[Presentation] 原発性アルドステロン症自験44例における耐糖能異常の頻度と特徴2011
- Author(s)
  後藤理英子、河島淳司、近藤龍也、水流添覚、下田誠也、宮村信博、荒木栄一
- Organizer
  第20回臨床内分泌Update
- Place of Presentation
  札幌、札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] シンポジウム「慢性炎症と糖代謝異常」熱ショック応答経路とインスリン抵抗性2011
- Author(s)
  近藤龍也、松山利奈、宮川克俊、後藤理英子、本島寛之、河島淳司、古川昇、水流添覚、荒木栄一
- Organizer
  第54回日本糖尿病学会学術総会
- Place of Presentation
  札幌、ロイトン札幌
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] Activation of Heat Shock Response Reduces Visceral Adiposity, Improves Insulin Resistance and Inflammatory Markers in Male Subjects with Metabolic Syndrome and Type 2 Diabetes2011
- Author(s)
  Tatsuya Kondo, Rina Matsuyama, Saori Koga, Katsutoshi Miyagawa, Rieko Goto, Mary Ann Suico, Junji Kawashima, Hiroyuki Motoshima, Noboru Furukawa, Kaku Tsuruzoe, Hirofumi Kai, Eiichi Araki
- Organizer
  ENDO 2011 (American Endocrine Society Meeting)
- Place of Presentation
  Boston, USA
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] Induction of HSP72, a Potential Novel Therapeutic Approach For Metabolic Syndrome and Type2Diabetes2010
- Author(s)
  Kondo T, Matsuyama R, Sasaki K, Morino-Koga S, Suico MA, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
- Organizer
  46th EASD Annual Meeting 20～ 24 Sept
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] メタボリックシンドロームに対する温熱・電流同時印加療法(MET)の内臓脂肪減少・代謝改善・慢性炎症マーカー低下効果2010
- Author(s)
  近藤龍也、佐々木一成、松山利奈、水流添覚、古川昇、本島寛之、河島淳司、古賀沙緒里、甲斐広文、荒木栄一
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山、岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 糖代謝改善をもたらす分子シャペロンHsp72制御療法の臨床応用を目指して2010
- Author(s)
  近藤龍也、佐々木一成、松山利奈、水流添覚、本島寛、古賀沙緒里、甲斐広文、荒木栄一
- Organizer
  第107回日本内科学会総会
- Place of Presentation
  東京、東京国際フォーラ
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] アポトーシス誘導転写因子CHOPの発現制御によるインスリン抵抗性改善効果の検証2009
- Author(s)
  近藤龍也、足立博紀、小川れい、佐々木一成、古川昇、本島寛之、河島淳司、水流添覚、高野優、榊田典治、荒木栄一
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪、大阪国際会議場
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] Knockdown of CHOP, an Inducer of Cellular Apoptosis upon Exesssive Endoplasmic Reticulum Stress, in Liver Ameliorates Insulin Resistance and Glucose Homeostasis in Mice Model of Type2Diabetes2009
- Author(s)
  Kondo T, Adachi H, Ogawa R, Sasaki K, Tsuruzoe K, Furukawa N, Motoshima H, Sakakida M, Araki E
- Organizer
  45th EASD Annual Meeting
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] Araki E2009
- Author(s)
  Kondo T, Adachi H, Ogawa R, Sasaki K, Tsuruzoe K, Furukawa N, Motoshima H, Sakakida M
- Organizer
  69th American Diabetes Association Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 小胞体ストレス関連分子CHOPの発現制御によるインスリン抵抗性改善作用の検証2009
- Author(s)
  近藤龍也、足立博紀、小川れい、佐々木一成、古川昇、本島寛之、河島淳司、水流添覚、高野優、榊田典治、荒木栄一
- Organizer
  第47回日本糖尿病学会九州地方会
- Place of Presentation
  福岡、リーガロイヤルホテル小倉
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 糖尿病と心疾患2008
- Author(s)
  水流添覚
- Organizer
  第5回九州心臓核医学研究会シンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2008-08-02
- Data Source
  KAKENHI-PROJECT-19591059
[Presentation] 糖尿病と心疾患2008
- Author(s)
  水流添覚
- Organizer
  第5回九州心臓核医学研究会
- Place of Presentation
  福岡市
- Year and Date
  2008-08-02
- Data Source
  KAKENHI-PROJECT-19591059
[Presentation] IRS-1過剰発現における脂肪蓄積と糖代謝についての解析2007
- Author(s)
  水流添覚, 村田雄介, 豊永哲至, 古川昇, 近藤龍也, 本島寛之, 井形元維, 竹田佳代, 佐々木一成, 荒木栄一
- Organizer
  第50回日本糖尿病学会総会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-19591059
[Presentation] IRS-1過剰発現マウスにおける脂肪蓄積と糖代謝についての解析2007
- Author(s)
  水流添覚(代表者)
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台市
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19591059
[Presentation] IRS-1遺伝子導入による脂肪量増加と耐糖能障害2007
- Author(s)
  水流添覚, 村田雄介, 竹田佳代, 近藤龍也, 本島寛之, 荒木栄一
- Organizer
  第45回日本糖尿病学会九州地方会
- Place of Presentation
  宮崎市
- Data Source
  KAKENHI-PROJECT-19591059

1. ARAKI Eiichi (10253733)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. NISHIKAWA Takeshi (70336212)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. MATSUMURA Takeshi (20398192)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. KONDO Tatsuya (70398204)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
5. TOYONAGA Tetsushi (60295128)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. MOTOSHIMA Hiroyuki (40398201)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
7. MIYAMURA Nobuhiro (40274716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. NISHIDA Kenro (50336244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FURUKAWA Noboru (90335795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 下田誠也 (60398203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSURUZOE Kaku 水流添 覚

Research Projects

Research Products

Co-Researchers

Identification of novel molecules associated with insulin action or insulin secretion induced by mild electric current and hyperthermia therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanisms of improvement of insulin resistance and reduction of visceral fat by combination of mild electrical current and thermo therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of reactive oxygen species in white and brown adipose tissuesin pathogenesis of insulin resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of insulin gene expression by small G protein related protein, Rho-kinase.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポリイミドを用いた易操作性超小型ブドウ糖センサの開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of pancreatic・cell function by Ca2+/calmodulin-dependent protein kinase II delta.-Analysis using CaM-KIIN, noble inhibitory protein, and constitutive active CaM kinase II-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脂肪細胞におけるインスリン作用伝達分子の発現調節と生体機能制御における意義

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A case of ectopic adrenocorticotropic hormoneproducing pancreatic neuroendocrine tumor with multiple liver metastases2010

Author(s)

Journal Title

Data Source

[Journal Article] Heat Shock Treatment with Mild Electrical Stimulation Safely Reduced Inflammatory Markers in Healthy Male Subjects2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010

Author(s)

Journal Title

Data Source

[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010

Author(s)

Journal Title

Data Source

[Journal Article] Angptl 4 deficiencyimproves lipid metabolism, suppresses foamcell formation and protects against atherosclerosis2009

Author(s)

Journal Title

Data Source

[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009

Author(s)

Journal Title

Data Source

[Journal Article] Oxidized low density lipoprotein activatesperoxisome proliferator-activatedreceptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages2008

Author(s)

Journal Title

Data Source

[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetes mice2008

Author(s)

Journal Title

Data Source

[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008

TSURUZOE Kaku 水流添覚