Akiyoshi Takeshi 秋好健志

… Alternative Names

AKIYOSHI Takeshi 秋好健志

Less

Researcher Number	50399143
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 准教授
Affiliation (based on the past Project Information) *help	2024: 慶應義塾大学, 薬学部(芝共立), 准教授 2019 – 2022: 慶應義塾大学, 薬学部(芝共立), 講師 2017: 慶應義塾大学, 薬学部(芝共立), 専任講師 2017: 慶應義塾大学, 薬学部(芝共立), 講師 2017: 慶應義塾大学, 薬学部, 専任講師 2016: 慶應義塾大学, 薬学部(芝共立), 助教 2013 – 2015: 慶應義塾大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Applied pharmacology / Medical pharmacy Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator トランスポーター / 消化管障害 / 抗がん剤曝露 / イリノテカン / 抗がん剤 / ダビガトラン / 5-FU / disease-drug interaction / 薬物動態 / 標的絶対定量プロテオミクス … More / OATP / SN-38 / トランスポーター発現 / イリノテカン曝露 / 標的絶対定量プロテオミクス解析 / 絶対定量プロテオミクス解析 / APTT / 吸収遅延 / 消化管吸収 / P-gp / Irinotecan / バイオアベイラビリティ / 難吸収性マーカー / アルミニウム定量法 / 体内動態 / 抗癌剤 … More Except Principal Investigator 遺伝子多型 / 薬物相互作用 / トランスポータ / 代謝酵素 / 飲食物 / 代謝阻害 / 薬物トランスポータ / 薬物代謝酵素 / テーラーメード薬物治療 / テーラーメイド薬物治療 / 不可逆的阻害 / テーラーメード医療 / 個人差 Less

Mechanisms of transporter-mediated Disease-Drug interactions and its clinical relevancePrincipal Investigator
- Principal Investigator
  
  秋好健志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Keio University
The influence of anticancer drug on the expression of transportersPrincipal Investigator
- Principal Investigator
  
  Akiyoshi Takeshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Keio University
The effect of gastrointestinal damage on drug absorptionPrincipal Investigator
- Principal Investigator
  
  AKIYOSHI Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Keio University
Quantitative analysis of the factors that confer inter-individual variation of the extent of beverage-drug interactions
- Principal Investigator
  
  Hisakazu OHTANI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Keio University
The effect of anticancer agent induced gastrointestinal damage on drug absorptionPrincipal Investigator
- Principal Investigator
  
  AKIYOSHI TAKESHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Keio University
Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450
- Principal Investigator
  
  OHTANI Hisakazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Inhibitory effects of cranberry juice and its ingredients on intestinal OATP1A2 and OATP2B1: Identification of avicularin as a novel inhibitor2022
- Author(s)
  Morita T, Akiyoshi T, Tsuchitani T, Kataoka H, Araki N, Yajima K, Katayama K, Imaoka A, Ohtani H
- Journal Title
  
  J Agric Food Chem
  
  Volume: 70 Issue: 10 Pages: 3310-3320
- DOI
  10.1021/acs.jafc.2c00065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-21K06585
[Journal Article] Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants.2022
- Author(s)
  Araki N, Morita T, Akiyoshi T, Kataoka H, Yajima K, Katayama K, Imaoka A and Ohtani H
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 00
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07173
[Journal Article] Inhibitory Potency and pH-dependence of OATP2B1 Inhibitors.2021
- Author(s)
  Sato R, Akiyoshi T, Morita T, Katayama K, Yajima K, Kataoka H, Imaoka A, Ohtani H.
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 41 Pages: 100416-100416
- DOI
  10.1016/j.dmpk.2021.100416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-21K06585
[Journal Article] The citrus fruit-derived flavanone glycoside narirutin is a novel potent inhibitor of organic anion-transporting polypeptides2020
- Author(s)
  Morita T, Akiyoshi T, Sato R, Uekusa Y, Katayama K, Yajima K, Imaoka A, Sugimoto Y, Kiuchi F, Ohtani H.
- Journal Title
  
  J Agric Food Chem
  
  Volume: 68 Issue: 48 Pages: 14182-14191
- DOI
  10.1021/acs.jafc.0c06132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-18K06758, KAKENHI-PROJECT-18K07302
[Journal Article] Effects of types of food on the extent of drug-drug interaction between activated charcoal and phenobarbital in rats.2019
- Author(s)
  Hattori T, Imaoka A, Akiyoshi T, Ohtani H.
- Journal Title
  
  Biopharm. Drug Dispos
  
  Volume: 40 Issue: 9 Pages: 315-324
- DOI
  10.1002/bdd.2205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07173
[Journal Article] pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A22019
- Author(s)
  T. Morita, T Akiyoshi, R. Sato, K. Katayama, K. Yajima, H. Kataoka, A. Imaoka, Y. Sugimoto, H. Ohtani
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 2 Pages: 220-227
- DOI
  10.1016/j.dmpk.2019.12.002
- NAID
  50014558590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06758, KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-18K07302
[Journal Article] 5-FU-induced gastrointestinal damage impairs the absorption and anticoagulant effects of dabigatran etexilate2018
- Author(s)
  Tsujii K, Hattori T, Imaoka A, Akiyoshi T, Ohtani H.
- Journal Title
  
  J Pharm Sci
  
  Volume: 107 Issue: 5 Pages: 1430-1433
- DOI
  10.1016/j.xphs.2017.12.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19166
[Journal Article] 5-Fluorouracil treatment alters the expression of intestinal transporters in rats2017
- Author(s)
  Yotsumoto K, Akiyoshi T, Wada N, Imaoka A,and Ohtani H
- Journal Title
  
  Biopharm. Drug Dispos
  
  Volume: 38 Issue: 9 Pages: 509-516
- DOI
  10.1002/bdd.2102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19166
[Journal Article] Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin2017
- Author(s)
  Ishikawa Yuko、Akiyoshi Takeshi、Imaoka Ayuko、Ohtani Hisakazu
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 38 Issue: 7 Pages: 420-425
- DOI
  10.1002/bdd.2078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08596
[Journal Article] Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D62015
- Author(s)
  Takeshi Akiyoshi, Miho Ishiuchi, Ayuko Imaoka, and Hisakazu Ohtani
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: in press
- NAID
  50014429969
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590668
[Journal Article] Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants.2013
- Author(s)
  114. T. Akiyoshi, M. Ito, S. Murase, M. Miyazaki, F.P. Guengerich, K. Nakamura, K. Yamamoto, H. Ohtani
- Journal Title
  
  Drug Metabol. Pharmacokinet
  
  Volume: 25(5) Pages: 411-415
- NAID
  130004933542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590668
[Journal Article] Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants2013
- Author(s)
  Takeshi Akiyoshi, Marie Ito, Saori Murase, Mitsue Miyazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto and Hisakazu Ohtani
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 28
- NAID
  130004933542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] ラット肝・腎・小腸組織におけるトランスポーター発現量解析とイリノテカン曝露の影響.2023
- Author(s)
  邉田桃子、秋好健志、矢島広大、土谷聡耀、今岡鮎子、大谷壽一.
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K07173
[Presentation] 定量的標的プロテオミクスを用いた変異型 OATP1A2/OATP2B1 の輸送特性の評価.2021
- Author(s)
  片岡寛樹、秋好健志、森田時生、矢島広大、今岡鮎子、片山和浩、内田康雄、寺崎哲也、大谷壽一.
- Organizer
  医療薬学フォーラム2021/第29回クリニカルファーマシーシンポジウム.
- Data Source
  KAKENHI-PROJECT-19K07173
[Presentation] High and low affinity kinetics of OATP2B1 - Inhibitory potency and pH-dependency of inhibitors2019
- Author(s)
  佐藤稜、秋好健志, 今岡鮎子、植草義徳、木内文之、片山和浩、杉本芳一、大谷壽一.
- Organizer
  日本薬物動態学会　第 34 年会
- Data Source
  KAKENHI-PROJECT-19K07173
[Presentation] Identification and characterization of a novel OATP2B1 inhibitor from citrus fruits juice2019
- Author(s)
  森田時生、秋好健志, 矢島広大、今岡鮎子、片山和浩、杉本芳一、大谷壽一
- Organizer
  第 13 回次世代を担う若手医療薬科学シンポジウム.
- Data Source
  KAKENHI-PROJECT-19K07173
[Presentation] 1)Comparative analysis of CYP2C19 enzyme kinetics among six genetic variants.2019
- Author(s)
  Watanabe D, Shimoji M, Seki H, Akiyoshi T, Imaoka A, Murakami A, Kishimoto H, Murayama N, Yamazaki H, Nakamura K, Ohtani H
- Organizer
  Asian Association of Schools of Pharmacy Conference.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07173
[Presentation] CYP2C19 代謝活性に対する天然果実成分の阻害様式及びキネティクスの評価2018
- Author(s)
  関博行, 秋好健志, 今岡鮎子, 大谷壽一.
- Organizer
  日本薬学会第 138 年会
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] イリノテカンによる消化管障害がジゴキシンの吸収に与える影響2017
- Author(s)
  土谷聡耀、今岡鮎子、秋好健志、大谷壽一
- Organizer
  第61回日本薬学会関東支部会
- Data Source
  KAKENHI-PROJECT-15K19166
[Presentation] CYP3A4 genetic variants に対する各種アゾール系抗真菌薬の阻害特性の比較2017
- Author(s)
  川村豪, 今岡鮎子, 秋好健志, 日比野英幸, 荒木拓也, 宮崎光江, F.P Guengerich, 中村克徳, 中村智徳, 山本康次郎, 大谷壽一
- Organizer
  日本薬学会第 137 年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] 5-FU誘発性消化管障害時のジゴキシンの吸収変動.2017
- Author(s)
  四元敬一, 今岡鮎子, 秋好健志, 大谷壽一
- Organizer
  第1回フレッシャーズ・カンファランス
- Data Source
  KAKENHI-PROJECT-15K19166
[Presentation] グレープフルーツジュース成分および resveratrol の CYP2C9 阻害特性解析2017
- Author(s)
  内山茉里夏, 秋好健志, 今岡鮎子, 大谷壽一
- Organizer
  日本薬学会第 137 年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] イリノテカン誘発性消化管障害時におけるダビガトランの吸収動態変動とその要因2017
- Author(s)
  服部智貴, 今岡鮎子, 秋好健志, 大谷壽一
- Organizer
  日本薬学会第 137 年会
- Data Source
  KAKENHI-PROJECT-15K19166
[Presentation] 5-FU による消化管障害時にはP-gp の発現量が著明に増大する2016
- Author(s)
  四元敬一、秋好健志、今岡鮎子、大谷壽一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜　(神奈川県横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K19166
[Presentation] 5-FU 曝露によるトランスポーター基質薬物の吸収過程への影響.2016
- Author(s)
  四元敬一, 今岡鮎子, 秋好健志, 大谷壽一.
- Organizer
  第 10 回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  群馬大学昭和キャンパス (前橋)
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K19166
[Presentation] イリノテカンによる消化管障害がダビガトランの吸収に及ぼす影響2016
- Author(s)
  服部智貴, 今岡鮎子, 秋好健志, 大谷壽一
- Organizer
  第 26 回日本医療薬学会年会
- Place of Presentation
  国立京都国際会館 (京都)
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K19166
[Presentation] CYP3A4 各変異型分子種の代謝活性に対する MBI 阻害剤の阻害強度の体系的比較2016
- Author(s)
  内藤里菜、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜 (神奈川県・横浜市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] CYP3A4 遺伝的 variant に対する競合阻害剤の阻害特性の体系的比較2015
- Author(s)
  綾華奈子、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、 F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  第53回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部 (千葉県・船橋市)
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] 各種CYP3A4変異型分子種に対するベラパミルおよびその代謝物のMBI特性2015
- Author(s)
  秋好健志、大橋拓人、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] CYP3A4遺伝的variantsに対する各種競合阻害剤の阻害特性の比較2015
- Author(s)
  綾華奈子、小林由季、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] 抗がん剤曝露時のダビガトラン- クラリスロマイシン薬物相互作用に対する消化管障害の影響2015
- Author(s)
  和田直樹、秋好健志、今岡鮎子、辻井一成、大谷壽一
- Organizer
  次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉大学亥鼻キャンパス 120周年記念講堂 (千葉県千葉市)
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15K19166
[Presentation] 各種CYP3A4変異型分子に対するグレープフルーツ果汁およびその成分のMBI特性2014
- Author(s)
  秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、Guengerich FP、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] In vitro データをもとにした、CYP2D6 variants における paroxetine の非線形体内動態の予測2014
- Author(s)
  丹羽しおり、秋好健志、今岡鮎子、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] CYP3A4変異型分子種におけるtestosterone及びmidazolamの代謝に対する競合阻害剤の阻害強度の比較2014
- Author(s)
  小縣淳子、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、Guengerich FP、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] 果実成分によるCYP3A4のMBI特性に対する遺伝子変異の影響2013
- Author(s)
  鈴木恵美、日比野英幸、秋好健志、村瀬沙織、荒木拓也、宮崎光江、Peter Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] ダビガトランの体内動態及び薬効に対する抗がん剤誘発消化管障害の影響
- Author(s)
  辻井一成、秋好健志、今岡鮎子、大谷壽一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860125
[Presentation] CYP3A4のMechanism-based inhibition は基質依存的に生じるか
- Author(s)
  石川裕子、秋好健志、今岡鮎子、大谷壽一
- Organizer
  医療薬学フォーラム2014
- Place of Presentation
  東京
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-24590668

1. OHTANI Hisakazu (70262029)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
2. IMAOKA Ayuko (10710957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. TSUJII Kazunari

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. YOTSUMOTO Keiichi

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. YAMAMOTO Koujirou (70174787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. WADA Naoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. HATTORI Tomoki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. TSUCHITANI Toshiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Akiyoshi Takeshi 秋好 健志

AKIYOSHI Takeshi 秋好 健志

Research Projects

Research Products

Co-Researchers

Mechanisms of transporter-mediated Disease-Drug interactions and its clinical relevancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The influence of anticancer drug on the expression of transportersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of gastrointestinal damage on drug absorptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative analysis of the factors that confer inter-individual variation of the extent of beverage-drug interactions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of anticancer agent induced gastrointestinal damage on drug absorptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibitory effects of cranberry juice and its ingredients on intestinal OATP1A2 and OATP2B1: Identification of avicularin as a novel inhibitor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of the inhibitory properties of the fruit component naringenin and its glycosides against OATP1A2 genetic variants.2022

Author(s)

Journal Title

Data Source

[Journal Article] Inhibitory Potency and pH-dependence of OATP2B1 Inhibitors.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The citrus fruit-derived flavanone glycoside narirutin is a novel potent inhibitor of organic anion-transporting polypeptides2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of types of food on the extent of drug-drug interaction between activated charcoal and phenobarbital in rats.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A22019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 5-FU-induced gastrointestinal damage impairs the absorption and anticoagulant effects of dabigatran etexilate2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 5-Fluorouracil treatment alters the expression of intestinal transporters in rats2017

Author(s)

Journal Title

DOI

Akiyoshi Takeshi 秋好健志

AKIYOSHI Takeshi 秋好健志