Matsushita Akio 松下明生

… Alternative Names

MATSUSITA Akio 松下明生

Less

Researcher Number	50402269
Other IDs
Affiliation (Current)	2025: 浜松医科大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 浜松医科大学, 医学部附属病院, 講師 2021 – 2023: 浜松医科大学, 医学部, 助教 2012 – 2017: 浜松医科大学, 医学部附属病院, 助教 2015: 埼玉医科大学, 医学部, 客員講師 2012: 埼玉医科大学, 医学部, 客員講師
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 53040:Nephrology-related / Endocrinology Except Principal Investigator General medical chemistry / Basic Section 54040:Metabolism and endocrinology-related / Endocrinology / Laboratory medicine / Neurology
Keywords	Principal Investigator 転写調節 / 転写制御 / 甲状腺ホルモン / 複合型下垂体機能低下症 / POU1F1 / TSHβ遺伝子 / 下垂体 / 転写因子 / アクアポリン２ / GATA2 … More / 抗利尿ホルモン / アクアポリン2 / 甲状腺ホルモン受容体 / 転写伸長因子 / 受容体 / 転写伸長反応 / 核内受容体 … More Except Principal Investigator GATA2 / 甲状腺ホルモン受容体 / 甲状腺ホルモン / 甲状腺刺激ホルモン / 発現制御 / 生体分子 / 核酸 / 遺伝子 / 酵素 / 転写調節 / T3受容体 / TRH / 下垂体 / 甲状腺自己免疫 / GATA3 / Foxp3 / 制御性T細胞 / バセドウ病 / 長鎖非コードRNA / メチル化 / TSH / 転写 / 視床下部 / 甲状腺刺激ホルモン放出ホルモン / transcription / thyroid hormone / thyrotropin / 副腎皮質刺激ホルモン / ネガティブフィードバック / 転写因子 Less

TSHβ鎖の発現調節におけるPIT1の作用機構の検討：新規抑制因子SRBPの同定Principal Investigator
- Principal Investigator
  
  松下明生
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Hamamatsu University School of Medicine
甲状腺ホルモンによる負の転写調節からみたバセドウ病の病因解明と治療戦略の探索
- Principal Investigator
  
  佐々木茂和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Nagoya City University
  Hamamatsu University School of Medicine
Study of body fluid regulation by thyroid hormone mediated by transcriptional regulation of aquaporin 2Principal Investigator
- Principal Investigator
  
  Matsushita Akio
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Hamamatsu University School of Medicine
GATA2 Mediates the Negative Regulation of the Prepro-Thyrotropin-Releasing Hormone Gene by Liganded T3 Receptor beta2 in the Paraventricular Nucleus of the Hypothalamus.
- Principal Investigator
  
  Sasaki Shigekazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Hamamatsu University School of Medicine
Involvement of transcription elongation factor in transcriptional regulation by thyroid hormone and its receptorPrincipal Investigator
- Principal Investigator
  
  Matsushita Akio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Hamamatsu University School of Medicine
Elucidation of molecular mechanism of function of long noncoding RNAs through methylation signal
- Principal Investigator
  
  KUROKAWA RIKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Saitama Medical University
The molecular mechanism of the linear-log relation between thyrotropin synthesis and T3
- Principal Investigator
  
  SASAKI Shigekazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Hamamatsu University School of Medicine
Elucidation of causative mechanism of amyotrophic lateral sclerosis via abnormality of methylation of TLS and development of its therapeutics.
- Principal Investigator
  
  KUROKAWA Riki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Saitama Medical University
Transcriptional mechanism of noncoding RNA
- Principal Investigator
  
  KUROKAWA Riki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Saitama Medical University

All 2023 2022 2021 2018 2017 2016 2014 2013 2011 Other

All Journal Article Presentation Book

[Book] かかりつけ医のための甲状腺疾患治療ガイド2023
- Author(s)
  松下明生
- Total Pages
  80
- Publisher
  診断と治療社
- ISBN
  9784787826114
- Data Source
  KAKENHI-PROJECT-21K08226
[Journal Article] Falsely elevated thyroid hormonh levels associated with fibrin interference in patients receiving oral anticoagulant therapy.2023
- Author(s)
  Tokumaru M, Ohba K, Kashiwabara Y, Takase H, Tayashi C, Iwaki T, Suzuki Y, Matsushita A, Sasaki S, Suda T, Maekawa M
- Journal Title
  
  Annals of Clinical Biochemistry
  
  Volume: － Issue: 4 Pages: 249-258
- DOI
  10.1177/00045632231159280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07823, KAKENHI-PROJECT-21K08226
[Journal Article] 甲状腺ホルモンの作用とその関連薬2023
- Author(s)
  松下明生
- Journal Title
  
  産科と婦人科
  
  Volume: 91 Pages: 72-78
- Data Source
  KAKENHI-PROJECT-21K08226
[Journal Article] The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin β Subunit Gene.2018
- Author(s)
  Sasaki S, Matsushita A, Kuroda G, Nakamura HM, Oki Y, Suda T.
- Journal Title
  
  Vitam Horm
  
  Volume: 106 Pages: 97-127
- DOI
  10.1016/bs.vh.2017.06.006
- ISBN
  9780128141168
- Data Source
  KAKENHI-PROJECT-15K09425
[Journal Article] Non-islet cell tumor-induced hypoglycemia associated with macronodular pulmonary metastases from poorly differentiated thyroid carcinoma.2014
- Author(s)
  Morioka T, Ohba K, Morita H, Takahashi G, Uchida H, Matsushita A, Sasaki S, Oki Y, Suda T, Kakudo K, Yoshino A.
- Journal Title
  
  Thyroid
  
  Volume: 24 Pages: 395-399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590689
[Journal Article] Essential Role of TEA Domain Transcription Factors in the Negative Regulation of the MYH 7 Gene by Thyroid Hormone and Its Receptors.2014
- Author(s)
  Iwaki H, Sasaki S, Matsushita A, Ohba K, Matsunaga H, Misawa H, Oki Y, Ishizuka K, Nakamura H, Suda T.
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590689
[Journal Article] Inappropriate elevation of serum thyrotropin levels in patients treated with axitinib.2013
- Author(s)
  Ohba K, Takayama T, Matsunaga H, Matsushita A, Sasaki S, Oki Y, Ozono S, Nakamura H.
- Journal Title
  
  Thyroid
  
  Volume: 23 Pages: 443-448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590689
[Journal Article] Factors associated with fluorine-18-fluorodeoxyglucose uptake in benign thyroid nodules.2013
- Author(s)
  Ohba K, Sasaki S, Oki Y, Nishizawa S, Matsushita A, Yoshino A, Suda T, Nakamura H.
- Journal Title
  
  Endocr J
  
  Volume: 60 Pages: 985-90
- NAID
  10031195768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590689
[Journal Article] A sudden onset and the spontaneous remission of severe hypo-high-density lipoprotein cholesterolemia without serious underlying disease: a case report.2013
- Author(s)
  Ohba K, Oki Y, Fujita K, Kameko F, Moriyama T, Horiike Y, Morita H, Matsushita A, Iino K, Sasaki S, Nakamura H, Maekawa M.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 15 Pages: 91-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590689
[Journal Article] TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation2011
- Author(s)
  Du, K., Arai, S., Kawamura, T., Matsushita, A., and Kurokawa, R.
- Journal Title
  
  BBRC
  
  Volume: 404 Issue: 4 Pages: 991-996
- DOI
  10.1016/j.bbrc.2010.12.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390057, KAKENHI-PROJECT-23659461
[Presentation] COVID19 ワクチン接種後に破壊性甲状腺炎を発症した 1 例2022
- Author(s)
  永田総一朗、松下明生、大場健司、黒田豪、佐々木茂和
- Organizer
  第 65 回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08226
[Presentation] 制御性 T 細胞(Treg)の分化決定因子 Foxp3 発現は転写因子 GATA3 によって活性化され，T3 によって負に調節される2022
- Author(s)
  佐々木茂和、大場健司、黒田豪、酒井勇輝、中村啓子、松下明生
- Organizer
  第95回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08226
[Presentation] 甲状腺ホルモンによるアクアポリン２の発現調節機構の検討2021
- Author(s)
  松下明生、新海信介、岩倉考政、酒井勇輝、黒田豪、中村啓子、大場健司、安田日出夫、佐々木茂和
- Organizer
  第64回日本甲状腺学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08226
[Presentation] 甲状腺ホルモンによる負の転写調節：視床下部と下垂体に共通な分子機構は存在するか？2018
- Author(s)
  黒田豪、佐々木茂和、松下明生、酒井勇輝、中村啓子、沖隆
- Organizer
  第91回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09425
[Presentation] GATA2 Mediates the Negative Regulation of the Prepro-Thyrotropin-Releasing Hormone Gene by Liganded T3 Receptor β2 in the Paraventricular Nucleus of the Hypothalamus.2018
- Author(s)
  Kuroda G, Sasaki S, Matsushita A, Nakamura H, Oki Y
- Organizer
  2018年米国内分泌学会(ENDO2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09425
[Presentation] prepro-TRH遺伝子のT3によるネガティブフィードバック機構には転写因子GATA2が関与する2017
- Author(s)
  黒田豪、佐々木茂和、松下明生、平原直子、中村啓子、沖隆
- Organizer
  第90回日本内分泌学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09425
[Presentation] The Role of GATA2 in the Negative Regulation of the Prepro- Thyrotropin-Releasing Hormone Gene By Liganded T3 Receptor Beta 22017
- Author(s)
  Kuroda G, Sasaki S, Matsushita A, Nakamura H, Yamashita M, Oki Y
- Organizer
  2017年米国内分泌学会(ENDO2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09425
[Presentation] prepro-TRH遺伝子のT3によるネガティブフィードバック機構には転写因子GATA2が関与する2017
- Author(s)
  黒田豪、佐々木茂和、松下明生、平原直子、三沢啓子、沖隆
- Organizer
  第90回日本内分泌学会学術総会
- Place of Presentation
  京都
- Year and Date
  2017-04-20
- Data Source
  KAKENHI-PROJECT-15K09425
[Presentation] T3によるpreproTRH遺伝子への負の調節における転写因子GATA2の意義2016
- Author(s)
  黒田　豪、佐々木　茂和、松下　明生、平原　直子、三沢　啓子、沖　隆
- Organizer
  第89回日本内分泌学会学術総会
- Place of Presentation
  京都
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K09425
[Presentation] 転写因子GATA2はT3によるprepro-TRH遺伝子への負の調節を媒介する2016
- Author(s)
  黒田豪、佐々木茂和、松下明生、平原直子、三沢啓子、沖隆
- Organizer
  第59 回日本甲状腺学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-15K09425
[Presentation] preproTRH遺伝子における転写因子GATA2ならびにT3受容体β２の作用2013
- Author(s)
  佐々木茂和、三沢啓子、松下明生、大場健司、松永英之、沖隆
- Organizer
  第86回日本内分泌学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24590689
[Presentation] T3-bound TR inhibits the expression of transcription factor GATA2, which is the key activator for the TSHÎβ gene2013
- Author(s)
  Shigekazu Sasaki, Hiroko Misawa Nakamura, Akio Matsushita, Hideyuki Matsunaga,Yutaka Oki
- Organizer
  Endocrine Society's 95th Annual Meeting
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-24590689
[Presentation] T3-bound TR inhibits the expression of transcription factor GATA2, which is the key activator for the TSHβ gene2013
- Author(s)
  Shigekazu Sasaki, Hiroko Misawa Nakamura, Akio Matsushita, Kenji Ohba, Hideyuki Matsunaga et al.
- Organizer
  The Endocrine Society's 95th Annual Meeting & Expo
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-24590689
[Presentation] 甲状腺ホルモン受容体は転写伸長因子P-TEFbと結合して転写を促進する
- Author(s)
  松下　明生
- Organizer
  第87回日本内分泌学会総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26461378

1. SASAKI Shigekazu (20303547)

# of Collaborated Projects: 5 results

# of Collaborated Products: 19 results
2. KUROKAWA Riki (70170107)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. OGAWA Sumito (20323579)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. FUJIMOTO KENTA (50403580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大場健司 (70649392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 古橋一樹 (70759935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松下一之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 前川真人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsushita Akio 松下 明生

MATSUSITA Akio 松下 明生

Research Projects

Research Products

Co-Researchers

TSHβ鎖の発現調節におけるPIT1の作用機構の検討：新規抑制因子SRBPの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

甲状腺ホルモンによる負の転写調節からみたバセドウ病の病因解明と治療戦略の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of body fluid regulation by thyroid hormone mediated by transcriptional regulation of aquaporin 2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

GATA2 Mediates the Negative Regulation of the Prepro-Thyrotropin-Releasing Hormone Gene by Liganded T3 Receptor beta2 in the Paraventricular Nucleus of the Hypothalamus.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of transcription elongation factor in transcriptional regulation by thyroid hormone and its receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanism of function of long noncoding RNAs through methylation signal

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanism of the linear-log relation between thyrotropin synthesis and T3

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of causative mechanism of amyotrophic lateral sclerosis via abnormality of methylation of TLS and development of its therapeutics.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional mechanism of noncoding RNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] かかりつけ医のための甲状腺疾患治療ガイド2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Falsely elevated thyroid hormonh levels associated with fibrin interference in patients receiving oral anticoagulant therapy.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 甲状腺ホルモンの作用とその関連薬2023

Author(s)

Journal Title

Data Source

[Journal Article] The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin β Subunit Gene.2018

Author(s)

Journal Title

DOI

ISBN

Data Source

Matsushita Akio 松下明生

MATSUSITA Akio 松下明生

[Presentation] COVID19 ワクチン接種後に破壊性甲状腺炎を発症した 1 例2022

[Presentation] 制御性 T 細胞(Treg)の分化決定因子 Foxp3 発現は転写因子 GATA3 によって活性化され，T3 によって負に調節される2022