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hisatomi toshio  久冨 智朗

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Hisatomi Toshio  久冨 智朗

HISATOMI Toshio  久冨 智朗

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Researcher Number 50404033
Other IDs
Affiliation (Current) 2025: 福岡大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 福岡大学, 医学部, 准教授
2018 – 2020: 九州大学, 医学研究院, 准教授
2017: 九州大学, 医学(系)研究科(研究院), 講師
2012: 国立病院機構九州医療センター, 眼科, 科長
2011 – 2012: 独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, その他
2009 – 2010: Kyushu University, 医学研究院, 助教
Review Section/Research Field
Principal Investigator
Ophthalmology
Except Principal Investigator
Basic Section 56060:Ophthalmology-related
Keywords
Principal Investigator
細胞死 / 眼細胞生物学 / 生理活性 / 病理学 / シグナル伝達 / 細胞・組織 / 血管内皮 / 網膜 / VEGF / ATP … More / 透過性亢進 / 糖尿病 / 黄斑浮腫 / 電子線トモグラフィー / 3次元再構築 / アポトーシス / 電子顕微鏡 … More
Except Principal Investigator
加齢黄斑変性 / 脂質代謝 / 脂質代謝異常 / 網膜変性 / リピドミクス / 網羅的脂質分析 / 酸化ストレス / ダノン病 / LAMP2 / リソソーム / オートファジー / 網膜 / 線維化 / レーザー誘発CNV)モデルマウス / 網膜下線維化 / 線維化モデルマウスにおけるagrin / 加齢黄斑変性患者における線維化率 / 線維化モデルマウス / 線維化阻害 / agrin / 網膜下線維化病変 / 増殖組織 / テネイシン / 質量分析 / 線維血管増殖 / 3次元構造解析 / ファイブロネクチン / 分子標的 / ペリオスチン / テネイシンC / 糖尿病網膜症 Less
  • Research Projects

    (6 results)
  • Research Products

    (45 results)
  • Co-Researchers

    (13 People)
  •  Lipidomic analysis in a mice model of early age-related macular degeneration

    • Principal Investigator
      Notomi Shoji
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Kyushu University
  •  Inhibition and treatment for subretinal fibrosis that occurs severe visual impairment in patients with age-related macular degeneration

    • Principal Investigator
      Shiose Satomi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Kyushu University
  •  Development of individualized molecular targeting therapy in the vitreous based on the specific genes in fibrovascular membrane.

    • Principal Investigator
      Yoshida Shigeo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Kurume University
  •  Therapeutic strategy for free ATP in retinal macular edemaPrincipal Investigator

    • Principal Investigator
      Hisatomi Toshio
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Fukuoka University
      Kyushu University
  •  The neuroprotection for photoreceptor apoptosis via selective antagonist, BBGPrincipal Investigator

    • Principal Investigator
      HISATOMI Toshio
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      国立病院機構九州医療センター
      National Hospital Organization, Kyushu Medical Center (Clinical Institute)
  •  Three dimensional reconstruction of electronmicroscopic images by New electron microscopic tomographyPrincipal Investigator

    • Principal Investigator
      HISATOMI Toshio
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Kyushu University

All 2024 2023 2022 2021 2020 2013 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Wide-Field Choroidal Thickness Analysis after Half-Fluence Photodynamic Therapy Combined with Intravitreal Aflibercept Injection in Pachychoroid Neovasculopathy2024

    • Author(s)
      Fukuda Yosuke、Notomi Shoji、Shiose Satomi、Maehara Yusuke、Kiyohara Kohei、Hashimoto Sawako、Kano Kumiko、Ishikawa Keijiro、Hisatomi Toshio、Sonoda Koh-Hei
    • Journal Title

      Journal of Clinical Medicine

      Volume: 13 Issue: 6 Pages: 1608-1608

    • DOI

      10.3390/jcm13061608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09702
  • [Journal Article] Differences in Central and Peripheral Choroidal Thickness among the Subtypes of Age-Related Macular Degeneration in an Asian Population2023

    • Author(s)
      Fukuda Yosuke、Notomi Shoji、Shiose Satomi、Kano Kumiko、Hashimoto Sawako、Fujiwara Kohta、Akiyama Masato、Ishikawa Keijiro、Hisatomi Toshio、Sonoda Koh-Hei
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 16 Pages: 5364-5364

    • DOI

      10.3390/jcm12165364

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09702
  • [Journal Article] TNFRSF10A downregulation induces retinal pigment epithelium degeneration during the pathogenesis of age-related macular degeneration and central serous chorioretinopathy2022

    • Author(s)
      Mori K, Ishikawa K, Fukuda Y, Rui ji, Wada I, Kubo Y, Akiyama M, Notomi Shoji, Murakami Y, Nakao S, Arakawa S, Shiose Satomi, Hisatomi T, Yoshida S, Ram Kannan, Sonoda KH
    • Journal Title

      Hum Mol Genet

      Volume: -

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K09931
  • [Journal Article] 眼疾患とバイオマーカー バイオマーカーの視覚化による疾患病態理解と治療法開発への挑戦2021

    • Author(s)
      久冨 智朗, 森 賢一郎, 立花 崇, 納冨 昭司, 石川 桂二郎, 武田 篤信, 大島 裕司, 金本 尚志, 江内田 寛, 吉田 茂生, 平形 明人, 西田 幸二, 大路 正人, 木村 和博, 久保田 敏昭, 緒方 奈保子, 松井 孝明, 吉富 文昭, 内尾 英一, 石橋 達朗, 園田 康平
    • Journal Title

      日本眼科学会雑誌 (0029-0203)125巻3号 Page266-284(2021.03)

      Volume: 125 Pages: 266-284

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11455
  • [Journal Article] Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy2020

    • Author(s)
      Kubo Yuki、Ishikawa Keijiro、Mori Kenichiro、Kobayashi Yoshiyuki、Nakama Takahito、Arima Mitsuru、Nakao Shintaro、Hisatomi Toshio、Haruta Masatoshi、Sonoda Koh-Hei、Yoshida Shigeo
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 9299-9299

    • DOI

      10.1038/s41598-020-66278-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09828, KAKENHI-PROJECT-18K09450, KAKENHI-PROJECT-19K18899
  • [Journal Article] Decrease in the number of microaneurysms in diabetic macular edema after anti-vascular endothelial growth factor therapy: implications for indocyanine green angiography-guided detection of refractory2020

    • Author(s)
      Mori K, Yoshida S, Kobayashi Y, Ishikawa K, Nakao S, Hisatomi T, Masatoshi Haruta, Ishibashi T
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 258 Issue: 4 Pages: 735-741

    • DOI

      10.1007/s00417-020-04608-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H05101, KAKENHI-PROJECT-18K09450
  • [Journal Article] Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage.2013

    • Author(s)
      Notomi S,Hisatomi T.et al.
    • Journal Title

      PLoS One

      Volume: 8(1)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Journal Article] The regulatory roles of apoptosis inducing factor in the formation and regresion processes of ocular neovascularization.2012

    • Author(s)
      Hisatomi T,Notomi S,et al.
    • Journal Title

      Am J Pathol

      Volume: 180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Journal Article] The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization.2012

    • Author(s)
      久冨智朗
    • Journal Title

      Am J Pathol.

      Volume: 181(1) Pages: 53-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Journal Article] MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration.2012

    • Author(s)
      Notomi S,Hisatomi T.et al.
    • Journal Title

      Am J Pathol.

      Volume: 181(4) Pages: 1378-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Journal Article] Critical Involvement of Extracellular ATP Acting on P2RX7 Purinergic Receptors in Photoreceptor Cell Death.2011

    • Author(s)
      Notomi S,Hisatomi T,et al.
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 2798-2809

    • NAID

      120005133085

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Journal Article] Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization.2011

    • Author(s)
      Salehi-Had H, Roh MI, Giani A, Hisatomi T, Nakao S, Kim IK, Gragoudas ES, Vavvas D, Guccione S, Miller JW.
    • Journal Title

      PLoS One. 6(4)

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] An animal model of spontaneous metabolic syndrome : Nile grass rat.2010

    • Author(s)
      Noda K, Melhorn MI, Zandi S, Frimmel S, Tayyari F, Hisatomi T, Almulki L, Pronczuk A, Hayes KC, Hafezi-Moghadam A.
    • Journal Title

      FASEB J. 24(7)

      Pages: 2443-2453

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] Establishment of a new animal model of focal subretinal fibrosis that resembles disciform lesion in advanced age-related macular degeneration.2010

    • Author(s)
      Jo YJ, Sonoda KH, Oshima Y, Takeda A, Kohno R, Yamada J, Hamuro J, Yang Y, Notomi S, Hisatomi T, Ishibashi T.
    • Journal Title

      Invest Ophthalmol Vis Sci. 4

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] Localization of vascular adhesion protein-1 (VAP-1) in the human eye.2010

    • Author(s)
      Almulki L, Noda K, Nakao S, Hisatomi T, Thomas KL, Hafezi-Moghadam A.
    • Journal Title

      Exp Eye Res. 90(1)

      Pages: 26-32

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] Histopathology of neovascular tissue from eyes with proliferative diabetic retinopathy after intravitreal bevacizumab injection.2010

    • Author(s)
      Kohno R, Hata Y, Mochizuki Y, Arita R, Kawahara S, Kita T, Miyazaki M, Hisatomi T, Ikeda Y, Aiello LP, Ishibashi T.
    • Journal Title

      Am J Ophthalmol. 150(2)

      Pages: 223-229

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] Retinitis pigmentosa associated with asteroid hyalosis.2010

    • Author(s)
      Ikeda Y, Hisatomi T, Murakami Y, Miyazaki M, Kohno R, Takahashi H, Hata Y, Ishibashi T.
    • Journal Title

      Retina. 30(8)

      Pages: 1278-1281

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis.2010

    • Author(s)
      Trichonas G, Murakami Y, Thanos A, Morizane Y, Kayama M, Debouck CM, Hisatomi T, Miller JW, Vavvas DG.
    • Journal Title

      Proc Natl Acad Sci U S A. 107(50)

      Pages: 21695-21700

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection.2009

    • Author(s)
      Hisatomi T, Ishibashi T, Miller JW, Kroemer G.
    • Journal Title

      Exp Neurol. 218(2)

      Pages: 347-352

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Journal Article] Surprising up-regulation of P-selectin glycoprotein ligand-1(PSGL-1)in endotoxin-induced uveitis.2009

    • Author(s)
      Almulki L, Noda K, Amini R, Schering A, Garland RC, Nakao S, Nakazawa T, Hisatomi T, Thomas KL, Masli S, Hafezi-Moghadam A.
    • Journal Title

      FASEB J. 23(3)

      Pages: 929-939

    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] バイオマーカーの視覚化による疾患病態理解と治療法開発への挑戦2020

    • Author(s)
      久冨智朗
    • Organizer
      第124回日本眼科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11455
  • [Presentation] 眼病理から考える高度近視の病態2012

    • Author(s)
      久冨 智朗
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] High biocompatibility of BBG depends on low cellular permeabillity into the live cells.2012

    • Author(s)
      久冨 智朗
    • Organizer
      World Ophthalmology Confence 2012(招待講演)
    • Place of Presentation
      アブダビ
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] Macular Holes-Update on Techniques and Tamponades2012

    • Author(s)
      久冨 智朗
    • Organizer
      The 27th APAO Congress
    • Place of Presentation
      釜山
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] Photoreceptor apoptosis in retinal diseases2012

    • Author(s)
      久冨 智朗
    • Organizer
      第116回日本眼科学会総会 シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] BBGと神経保護作用2012

    • Author(s)
      納富 昭司、久冨智朗
    • Organizer
      第1回 HMS Japan
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] マウス網膜下出血モデルにおけるブリリアントブルーGの効果2012

    • Author(s)
      納富 昭司、久冨智朗
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] P2X7受容体遮断薬Brilliant Blue Gによる網膜神経細胞保護効果の検討2011

    • Author(s)
      納富昭司、久冨智朗
    • Organizer
      班会議
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] Brilliant Blue Gの細胞染色性と細胞膜透過性の検討2011

    • Author(s)
      久冨智朗
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] High biocompatibility of BBG depends on low cellular permeabillity into the live cells.2011

    • Author(s)
      久冨 智朗
    • Organizer
      ARVO
    • Place of Presentation
      フロリダ
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] P2X7受容体遮断薬Brilliant Blue Gによる網膜神経細胞保護効果の検討2011

    • Author(s)
      納富昭司、久冨智朗
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] Brilliant Blue G の細胞染色性と細胞膜透過性の検討2011

    • Author(s)
      久冨 智朗
    • Organizer
      日本眼科学会(招待講演)
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791991
  • [Presentation] マウス脈絡膜新生血管の蛍光走査型電子顕微鏡(FL-SEM)による観察2011

    • Author(s)
      納富昭司・久冨智朗
    • Organizer
      日本眼科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-16
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] Brilliant Blue Gの細胞染色性と細胞膜透過性の検討2011

    • Author(s)
      久冨智朗
    • Organizer
      班会議
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 胞状網膜剥離と浅い網膜剥離における視細胞死の比較2010

    • Author(s)
      久冨智朗
    • Organizer
      日本眼科学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] マウス脈絡膜新生血管の蛍光走査型電子顕微鏡(FL-SEM)による観察2010

    • Author(s)
      納富昭司、久冨智朗
    • Organizer
      日本眼科学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 胞状網膜剥離と浅い網膜剥離における視細胞死の比較2010

    • Author(s)
      久冨智朗
    • Organizer
      分子生物学研究会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] マウス脈絡膜新生血管の蛍光走査型電子顕微鏡(FL-SEM)による観察2010

    • Author(s)
      納富昭司、久冨智朗
    • Organizer
      分子生物学研究会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 網膜剥離による視細胞死;ミトコンドリア脂質二重膜透過性亢進を介した分子機構2009

    • Author(s)
      久冨智朗
    • Organizer
      眼分子生物学研究会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 網膜剥離でなぜ視細胞は変性するのか? ミトコンドリアの謎(インストラクションコース)2009

    • Author(s)
      久冨智朗
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 網膜剥離と視細胞死;ミトコンドリア透過性亢進を介した分子機構2009

    • Author(s)
      久冨智朗
    • Organizer
      北九州九州大学眼科同門会
    • Place of Presentation
      小倉
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 視細胞保護と血管新生抑制におけるアポトーシスの関与2009

    • Author(s)
      久冨智朗、納富昭司
    • Organizer
      眼創傷治癒研究会
    • Place of Presentation
      仙台
    • Year and Date
      2009-08-07
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 網膜剥離による視細胞死;ミトコンドリア脂質二重膜透過性亢進をした分子機構2009

    • Author(s)
      久冨智朗
    • Organizer
      若手神経保護研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-26
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] 眼科血管・リンパ管研究の最前線 実験的脈絡膜血管新生の発生および退縮過程 におけるアポトーシスの発生と役割(シンポジウム)2009

    • Author(s)
      久冨智朗
    • Organizer
      日本眼科学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21791690
  • [Presentation] The Bird's Eye View Analysis of Internal limiting membrane ; Cellular migration around the macular hole2009

    • Author(s)
      Toshio Hisatomi
    • Organizer
      JCK meeting
    • Place of Presentation
      Fukuoka
    • Data Source
      KAKENHI-PROJECT-21791690
  • 1.  園田 康平 (10294943)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  石川 桂二郎 (00795304)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  Yoshida Shigeo (50363370)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  池田 康博 (20380389)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  Shiose Satomi (90644758)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  Notomi Shoji (10836563)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  中尾 新太郎 (50583027)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  秋山 雅人 (10757686)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  有馬 充 (60772845)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  中間 崇仁 (30827556)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  武田 篤信 (40560313)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  村上 祐介 (50634995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  長谷川 英一 (70636521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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