Ohkubo Hirotoki 大久保博世

Researcher Number	50406930
Affiliation (based on the past Project Information) *help	2016 – 2020: 北里大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery
Keywords	Principal Investigator 脂質メディエーター / 内皮 / 内皮細胞 / 類洞 / 肝臓 / 肝類洞閉塞 / 類洞内皮 / トロンボキサン / 肝類洞閉塞症候群 / 外科 … More / 再生医学 / プロスタグランディン / 再灌流 / 再潅流 / プロスタグランジン / 肝修復 Less

Role of lipid mediators in hepatic sinusoidal obstruction syndromePrincipal Investigator
- Principal Investigator
  
  Ohkubo Hirotoki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kitasato University
Regulation of liver repair via PGE receptor signalingPrincipal Investigator
- Principal Investigator
  
  Ohkubo Hirotoki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kitasato University

All 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Risk Factors for Progression of Distal Deep Vein Thrombosis2020
- Author(s)
  Fujioka Shunichiro、Ohkubo Hirotoki、Kitamura Tadashi、Mishima Toshiaki、Onishi Yoshihiko、Tadokoro Yuki、Araki Haruna、Matsushiro Takuya、Yakuwa Kazuki、Miyamoto Takashi、Torii Shinzo、Miyaji Kagami
- Journal Title
  
  Circ J
  
  Volume: 84 Issue: 10 Pages: 1862-1865
- DOI
  10.1253/circj.CJ-20-0270
- NAID
  130007907589
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2020-09-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16330
[Journal Article] Regional thigh tissue oxygen saturation during cardiopulmonary bypass predicts acute kidney injury after cardiac surgery2020
- Author(s)
  Sakaki Kenjiro、Kitamura Tadashi、Kohira Satoshi、Torii Shinzo、Mishima Toshiaki、Hanayama Naoji、Kobayashi Kensuke、Ohkubo Hirotoki、Miyaji Kagami
- Journal Title
  
  Journal of Artificial Organs
  
  Volume: 23 Issue: 4 Pages: 315-320
- DOI
  10.1007/s10047-020-01175-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16330, KAKENHI-PROJECT-18K16994
[Journal Article] Thromboxane A(2) receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury.2019
- Author(s)
  Otaka F, Ito Y, Inoue T, Ohkubo H, Nishizawa N, Kojo K, Betto T, Yamane S, Narumiya S, Koizumi W, Majima M
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 381 Pages: 114733-114733
- DOI
  10.1016/j.taap.2019.114733
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09156, KAKENHI-PROJECT-18K16330, KAKENHI-PROJECT-18H02605, KAKENHI-PROJECT-18K15760
[Journal Article] Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.2018
- Author(s)
  Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M.
- Journal Title
  
  J Hepatol.
  
  Volume: S0168-8278(18) Issue: 1 Pages: 30126-30130
- DOI
  10.1016/j.jhep.2018.02.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293055, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-16K21350, KAKENHI-PROJECT-18K15760, KAKENHI-PROJECT-18K16330, KAKENHI-PROJECT-18K16373, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-18H02605, KAKENHI-PROJECT-16K10581, KAKENHI-PROJECT-17K19543
[Journal Article] Factors associated with a low initial cerebral oxygen saturation value in patients undergoing cardiac surgery2017
- Author(s)
  Kobayashi Kensuke、Kitamura Tadashi、Kohira Satoshi、Torii Shinzo、Horai Tetsuya、Hirata Mitsuhiro、Mishima Toshiaki、Sughimoto Koichi、Ohkubo Hirotoki、Irisawa Yusuke、Matsushiro Takuya、Hayashi Hidenori、Miyata Yurie、Tsuchida Yuta、Ohtomo Naoki、Miyaji Kagami
- Journal Title
  
  Journal of Artificial Organs
  
  Volume: 20 Issue: 2 Pages: 110-116
- DOI
  10.1007/s10047-016-0941-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21350
[Journal Article] BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils2016
- Author(s)
  Kojo, K., Ito, Y., Eshima, K., Nishizawa, N., Ohkubo, H., Yokomizo, T., Shimizu, T., Watanabe, M.,Majima, M.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 29650-29650
- DOI
  10.1038/srep29650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-24229003, KAKENHI-PROJECT-15H04708, KAKENHI-PROJECT-26293055, KAKENHI-PROJECT-15K15056, KAKENHI-PROJECT-26430120, KAKENHI-PROJECT-16K21350
[Presentation] 肝類洞閉塞症候群におけるトロンボキサンA2受容体の役割について2020
- Author(s)
  大高史聖、伊藤義也、井上智仁、大久保博世、津留世里、細野加奈子、小泉和三郎、馬嶋正隆
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K16330
[Presentation] RAMP1 signaling in hepatic macrophages plays a critical role in immune-mediated hepatitis2019
- Author(s)
  伊藤義也、井上智仁、大高史聖、美島利昭、大久保博世、馬嶋正隆
- Organizer
  日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K16330
[Presentation] トロンボキサンA2受容体シグナルの肝類洞閉塞症候群における役割2019
- Author(s)
  伊藤義也、大高史聖、大久保博世、馬嶋正隆
- Organizer
  肝類洞壁細胞研究会学術集会
- Data Source
  KAKENHI-PROJECT-18K16330
[Presentation] Prostaglandin E receptor subtype EP3 promotes liver repair after acute liver injury2019
- Author(s)
  S Nakamoto, Y Ito, N Nishizawa, H Ohkubo, M Watanabe, M Majima.
- Organizer
  第44回日本微小循環学会総会
- Data Source
  KAKENHI-PROJECT-18K16330
[Presentation] Role of endogenous PGE2 in liver repair after hepatic ischemia/reperfusion2018
- Author(s)
  Yoshiya Ito, Nobuyuki Nishizawa, Koji Eshima, Hirotoki Ohkubo, Tomoyoshi Inoue, Hideki Amano, Masataka Majima.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16330
[Presentation] PGE2 Derived from Microsomal Prostaglandin E Synthase-1 (Mpges-1) Induces Hepatic Ischemia/Reperfusion Injury through EP4 Receptor Signaling2017
- Author(s)
  Nobuyuki Nishizawa, Yoshiya Ito, Ken Kojo, Hirotoki Ohkubo, Masahiko Watanabe, Masataka Majima.
- Organizer
  40th ANNUAL CONFERENCE ON SHOCK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21350
[Presentation] 肝虚血再潅流障害後の肝修復過程におけるプロスタグランジンE2 の役割2017
- Author(s)
  伊藤義也、西澤伸恭、大久保博世、古城憲、井上智仁、中本修治、大高史聖、都留世里、天野英樹、馬嶋正隆
- Organizer
  第31 回肝類洞壁細胞研究会学術集会
- Data Source
  KAKENHI-PROJECT-16K21350
[Presentation] An inducible microsomal prostaglandin E syunthase-1 (mPGES-1) contributes to hepatic ischemia/reperfusion injury via PGE2/EP4 receptors.2016
- Author(s)
  Ohkubo H, Ito Y, Nishizawa N, Inoue T, Kojo K, Amano H, Watanabe M, Majima M.
- Organizer
  The 8th Congress of International Federation of Shock Societies
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-10-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21350

1. 横溝岳彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 伊藤義也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 馬嶋正隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohkubo Hirotoki 大久保 博世

Research Projects

Research Products

Co-Researchers

Role of lipid mediators in hepatic sinusoidal obstruction syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of liver repair via PGE receptor signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Risk Factors for Progression of Distal Deep Vein Thrombosis2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Regional thigh tissue oxygen saturation during cardiopulmonary bypass predicts acute kidney injury after cardiac surgery2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Thromboxane A(2) receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Factors associated with a low initial cerebral oxygen saturation value in patients undergoing cardiac surgery2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 肝類洞閉塞症候群におけるトロンボキサンA2受容体の役割について2020

Author(s)

Organizer

Data Source

[Presentation] RAMP1 signaling in hepatic macrophages plays a critical role in immune-mediated hepatitis2019

Author(s)

Organizer

Data Source

[Presentation] トロンボキサンA2受容体シグナルの肝類洞閉塞症候群における役割2019

Author(s)

Organizer

Data Source

[Presentation] Prostaglandin E receptor subtype EP3 promotes liver repair after acute liver injury2019

Author(s)

Organizer

Data Source

[Presentation] Role of endogenous PGE2 in liver repair after hepatic ischemia/reperfusion2018

Author(s)

Organizer

Data Source

[Presentation] PGE2 Derived from Microsomal Prostaglandin E Synthase-1 (Mpges-1) Induces Hepatic Ischemia/Reperfusion Injury through EP4 Receptor Signaling2017

Author(s)

Organizer

Data Source

[Presentation] 肝虚血再潅流障害後の肝修復過程におけるプロスタグランジンE2 の役割2017

Author(s)

Organizer

Data Source

[Presentation] An inducible microsomal prostaglandin E syunthase-1 (mPGES-1) contributes to hepatic ischemia/reperfusion injury via PGE2/EP4 receptors.2016

Author(s)

Ohkubo Hirotoki 大久保博世