Hashizume Kohei 橋爪公平

… Alternative Names

橋爪公平ハシヅメコウヘイ

HASHIZUME Kohei 橋爪公平

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Researcher Number	50407095
Affiliation (Current)	2025: 岩手医科大学, 医学部, 特任准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 岩手医科大学, 医学部, 特任准教授 2019: 岩手医科大学, 医学部, 特任准教授 2016 – 2018: 岩手医科大学, 医学部, 講師 2015: 岩手医科大学, 眼科学, 助教 2012 – 2015: 岩手医科大学, 医学部, 助教 2010 – 2011: 岩手医科大学, 医学部, 研究員 2007 – 2008: Iwate Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Ophthalmology / Basic Section 56060:Ophthalmology-related Except Principal Investigator Ophthalmology / Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator 加齢性眼疾患 / 酸化ストレス / 白内障 / 網膜変性 / 加齢黄斑変性 / 網膜色素上皮細胞 / 増殖硝子体網膜症 / 網膜剥離 / オートファジー / 加齢 … More / ステロイド / ポリフェノール / 抗酸化 / 糖尿病 / 抗加齢医学 / 眼科学 / VAP-1 / SSAO / 遺伝子 / ビタミンC / 抗酸化能 / 遺伝子多型 … More Except Principal Investigator TGF-β / 水晶体上皮細胞 / ROCK阻害剤 / 上皮間葉系移行 / 前嚢下白内障 / 上皮間葉系転換 / 細胞内シグナル伝達 / FGF / TAZ / YAP / 網膜色素上皮細胞 / シグナル伝達 / Ｉ型コラーゲン / I型コラーゲン / 白内障 / Rock / MRTF / Y-27632 / Rhoキナーゼ / Rock inhibitor Less

網膜変性におけるオートファジーの役割の解析Principal Investigator
- Principal Investigator
  
  橋爪公平
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Iwate Medical University
Analysis of Intracellular Signaling Mechanisms in Epithelial-Mesenchymal Transition of Lens Epithelial Cells
- Principal Investigator
  
  Kurosaka Daijiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Iwate Medical University
A role of MRTF inepithelial-mesenchymal transition induced by TGF-b
- Principal Investigator
  
  KUROSAKA DAIJIRO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Iwate Medical University
Suppression of cataract by antioxidant and antistress agentPrincipal Investigator
- Principal Investigator
  
  Hashizume Kouhei
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Iwate Medical University
Role of Rho kinase on epithelial mesenchymal transformation of lens epithelial cells induced by TGF-b
- Principal Investigator
  
  Kurosaka Daijiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Iwate Medical University
Effect of semicarbazide-sensitive monoamine oxidase inhibitors on age-related eye diseasePrincipal Investigator
- Principal Investigator
  
  HASHIZUME Kohei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Iwate Medical University
Analysis of retinal degeneration in vitamin C knockout micePrincipal Investigator
- Principal Investigator
  
  HASHIZUME Kohei
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Iwate Medical University
Genetic polymorphisms associated with age-related ophthalmic diseasePrincipal Investigator
- Principal Investigator
  
  HASHIZUME Kohei
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Iwate Medical University

All 2024 2020 2015 2014 2012 2008 2007 Other

All Journal Article Presentation

[Journal Article] Inhibition of Connective Tissue Growth Factor Expression in Adult Retinal Pigment Epithelial-19 Cells by Blocking Yes-Associated Protein/Transcriptional Coactivator with PDZ-Binding Motif Activity2024
- Author(s)
  Murakami Yoko、Imaizumi Toshiyasu、Hashizume Kouhei、Tezuka Yu、Oku Yusuke、Nishiya Naoyuki、Sanbe Atsushi、Kurosaka Daijiro
- Journal Title
  
  Journal of Ocular Pharmacology and Therapeutics
  
  Volume: - Issue: 4 Pages: 246-252
- DOI
  10.1089/jop.2023.0141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09750
[Journal Article] Rho/myocardin-related transcription factor A (MRTF-A) pathway plays an important role in TGF-β-induced epithelial mesenchymal transition in retinal pigment epithelial cells.2020
- Author(s)
  Umi Tanaka, Daijiro Kurosaka, Kenichi Murai, Kouhei hashizume, Kazuhiro Fukuda, Sora Itsukaichi Atsushi Sanbe
- Journal Title
  
  Journal of Iwate Medical Assiociation
  
  Volume: -
- NAID
  130007978401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11465
[Journal Article] Effect of astaxanthin on cataract formation induced by glucocorticoids in the chick embryo.2015
- Author(s)
  Ishikawa S, Hashizume K, Nishigori H, Tezuka Y, Sanbe A, Kurosaka D
- Journal Title
  
  Curr Eye Res
  
  Volume: 40 Pages: 535-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592640
[Journal Article] アスタキサンチンの抗酸化作用による鶏胚グルココルチコイド誘発白内障の抑制2015
- Author(s)
  石川清乃、橋爪公平、西郡秀夫、手塚優、三部篤、黒坂大次郎
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 119 Pages: 78-79
- Data Source
  KAKENHI-PROJECT-24592640
[Journal Article] Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice2012
- Author(s)
  Ishikawa Y, Hashizume K, Kishimoto S, Tezuka Y, Nishigori H, Yamamoto N, Kondo Y, Maruyama N, Ishigami A, and Kurosaka D
- Journal Title
  
  Exp Eye Res
  
  Pages: 85-89
- Data Source
  KAKENHI-PROJECT-22791681
[Journal Article] Retinal Dysfunction and Progressive Retinal Cell Death in SOD1-Deficient Mice2008
- Author(s)
  Kouhei Hashizume , Manabu Hirasawa, Yutaka Imamura, Setsuko Noda, Takahiko Shimizu, Kei Shinoda, Toshihide Kurihara, Kosuke Noda, Yoko Ozawa, Susumu Ishida, Yozo Miyake, Takuji Shirasawa, Kazuo Tsubota
- Journal Title
  
  Am J Pathol 27
  
  Pages: 1325-1331
- Data Source
  KAKENHI-PROJECT-19791287
[Presentation] 水晶体上皮細胞のI型コラーゲン産生に対する線維芽細胞増殖因子の影響2024
- Author(s)
  黒坂大次郎, 板持雅知, 亀井翔太, 今泉利康, 橋爪公平
- Organizer
  第128回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-21K09750
[Presentation] アスタキサンチンの抗酸化作用による鶏胚グルココルチコイド誘発白内障の抑制2014
- Author(s)
  石川清乃、橋爪公平、西郡秀夫、手塚優、三部篤、黒坂大次郎
- Organizer
  第53回日本白内障学会総会
- Place of Presentation
  グリーンウインド（TKPガーデンシティ品川）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24592640
[Presentation] Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice2012
- Author(s)
  Ishikawa S, Ishikawa Y, Hashizume K, Kishimoto S, Tezuka Y, Nishigori H, Yamamoto N, Kondo Y, Ishigami A, and Kurosaka D
- Organizer
  International Conference on the Lens
- Place of Presentation
  Hawaii Kona, USA
- Year and Date
  2012-01-17
- Data Source
  KAKENHI-PROJECT-22791681
[Presentation] Oxidative stress markers in Japanese patients with agerelated macular degeneration ; a pilot study2008
- Author(s)
  Kotihei Hashizume
- Organizer
  The Association for Research in Vision and Ophthalmology Meeting
- Place of Presentation
  Fortlauderdale Florida, USA
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-19791287
[Presentation] 加齢黄斑変性(AMD)の酸化ストレスマーカー検索2008
- Author(s)
  石川陽平、橋爪公平、早川真奈、高橋公美、藤原貴光、町田繁樹、黒坂大次郎、坪田一男、澤登雅一
- Organizer
  臨床眼科学会
- Data Source
  KAKENHI-PROJECT-19791287
[Presentation] Oxidative stress markers in Japanese patients with age-related macular degeneration : a pilot study2008
- Author(s)
  Kouhei Hashizume, Yutaka Imamura, Manabu Hirasawa, Masakazu Sawanobori, Susumu Ishida, Daijiro Kurosaka, Kazuo Tsubota
- Organizer
  The Association for Research in Vision and Ophthalmology Meeting
- Data Source
  KAKENHI-PROJECT-19791287
[Presentation] 加齢黄斑変性における酸化ストレスマーカーの評価2007
- Author(s)
  橋爪公平
- Organizer
  日本臨床眼科学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19791287
[Presentation] 加齢黄斑変性における酸化ストレスマーカーの評価2007
- Author(s)
  橋爪公平、町田繁樹、黒坂大次郎、今村裕、平澤学、井上真、坪田一男、澤登雅一
- Organizer
  抗加齢医学会
- Data Source
  KAKENHI-PROJECT-19791287
[Presentation] 加齢黄斑変性における酸化ストレスマーカーの評価2007
- Author(s)
  橋爪公平、町田繁樹、黒坂大次郎、平澤学、今村裕、坪田一男、澤登雅一
- Organizer
  臨床眼科学会
- Data Source
  KAKENHI-PROJECT-19791287
[Presentation] UVB不可によるHSF1ヘテロマウス水晶体中のクリスタリン量の変化
- Author(s)
  石川清乃、橋爪公平、三部敦、西郡秀夫、黒坂大次郎
- Organizer
  第52回日本白内障学会
- Place of Presentation
  シェラトン・グランデ・トーキョー・ベイ・ホテル、ヒルトン東京ベイ
- Data Source
  KAKENHI-PROJECT-24592640
[Presentation] UVB負荷によるheat shock transcription factor 1（HSF1）ヘテロマウス水晶体の変化
- Author(s)
  橋爪公平、三部篤、西郡秀夫、黒坂大次郎
- Organizer
  第51回日本白内障学会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24592640
[Presentation] UVB負荷によるHSF1ヘテロマウス水晶体中のクリスタリン量の変化
- Author(s)
  石川清乃、橋爪公平、三部篤、西郡秀夫、黒坂大次郎
- Organizer
  第52回日本白内障学会
- Place of Presentation
  シェラトン・グランデ・トーキョー・ベイ・ホテル、ヒルトン東京ベイ
- Data Source
  KAKENHI-PROJECT-24592640
[Presentation] Effect of green tea polyphenols on cataract formation induced by glucocorticoids in the chick embryo
- Author(s)
  Satoshi Ogasawara, Kouhei Hashizume, Kanako Maeda, Sayano Ishikawa, Hideo Nishigori, Atsushi Sanbe, Daijiro Kurosaka
- Organizer
  The association for research in vision and ophthalmology
- Place of Presentation
  米国デンバー
- Year and Date
  2015-05-03 – 2015-05-07
- Data Source
  KAKENHI-PROJECT-24592640

1. Kurosaka Daijiro (20215099)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. TAMADA Kunifusa (20583610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 木澤純也 (40433487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IMAIZUMI Toshiyasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hashizume Kohei 橋爪 公平

橋爪 公平 ハシヅメ コウヘイ

HASHIZUME Kohei 橋爪 公平

Research Projects

Research Products

Co-Researchers

網膜変性におけるオートファジーの役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of Intracellular Signaling Mechanisms in Epithelial-Mesenchymal Transition of Lens Epithelial Cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A role of MRTF inepithelial-mesenchymal transition induced by TGF-b

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of cataract by antioxidant and antistress agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Rho kinase on epithelial mesenchymal transformation of lens epithelial cells induced by TGF-b

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of semicarbazide-sensitive monoamine oxidase inhibitors on age-related eye diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of retinal degeneration in vitamin C knockout micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic polymorphisms associated with age-related ophthalmic diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of Connective Tissue Growth Factor Expression in Adult Retinal Pigment Epithelial-19 Cells by Blocking Yes-Associated Protein/Transcriptional Coactivator with PDZ-Binding Motif Activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rho/myocardin-related transcription factor A (MRTF-A) pathway plays an important role in TGF-β-induced epithelial mesenchymal transition in retinal pigment epithelial cells.2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effect of astaxanthin on cataract formation induced by glucocorticoids in the chick embryo.2015

Author(s)

Journal Title

Data Source

[Journal Article] アスタキサンチンの抗酸化作用による鶏胚グルココルチコイド誘発白内障の抑制2015

Author(s)

Journal Title

Data Source

[Journal Article] Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice2012

Author(s)

Journal Title

Data Source

[Journal Article] Retinal Dysfunction and Progressive Retinal Cell Death in SOD1-Deficient Mice2008

Author(s)

Journal Title

Data Source

Hashizume Kohei 橋爪公平

橋爪公平ハシヅメコウヘイ

HASHIZUME Kohei 橋爪公平