Setoguchi Ruka 瀬戸口留可

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SETOGUCHI Ruka 瀬戸口留可

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Researcher Number	50415204
Other IDs
Affiliation (Current)	2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授
Affiliation (based on the past Project Information) *help	2025: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2020 – 2021: 東京大学, 大学院薬学系研究科(薬学部), 准教授 2018 – 2019: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2014 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2012: 京都大学, 医学(系)研究科(研究院), 准教授 2012: 京都大学, 医学研究科, 特定准教授 2011: 京都大学, 医学(系)研究科(研究院), 講師
Review Section/Research Field	Principal Investigator Immunology / Transformative Research Areas, Section (III) / Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator 免疫記憶 / 免疫学的記憶 / 腸内細菌 / 自己抗原 / CD8 T細胞 / 大腸恒常性 / 記憶T細胞 / サイトカイン / ウイルス / 感染 / 免疫 / MHCクラスII / 恒常性維持

Research Projects
(4 results)
Research Products
(17 results)

MHCクラスIIによる新規自己指向性免疫制御機構の解明Principal Investigator
- Principal Investigator
  
  瀬戸口留可
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Elucidating a novel MHC class II-dependent mechanism which maintains the homeostasis of memory CD8 T cellsPrincipal Investigator
- Principal Investigator
  
  Setoguchi Ruka
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
  Institute of Physical and Chemical Research
Elucidating the molecular basis of memory CD8+ T cell maintenancePrincipal Investigator
- Principal Investigator
  
  Setoguchi Ruka
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
How MHC class II molecules promote memory CD8 T cell homeostasisPrincipal Investigator
- Principal Investigator
  
  SETOGUCHI Ruka
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2021 2020 2019 2018 2016 2015 2012 2011

All Journal Article Presentation Book

[Book] 「メモリーCD8T細胞の恒常性維持メカニズム」免疫記憶の制御と疾患治療2011
- Author(s)
  瀬戸口留可
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790549
[Book] 免疫記憶の制御と疾患治療2011
- Author(s)
  瀬戸口　留可
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23790549
[Journal Article] IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature.2016
- Author(s)
  Setoguchi R
- Journal Title
  
  International Immunology
  
  Volume: 未決定 Issue: 6 Pages: 293-305
- DOI
  10.1093/intimm/dxw004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860325
[Journal Article] mTOR signaling promotes a robust and continuous production of IFN-γ by human memory CD8+ T cells and their proliferation2015
- Author(s)
  Setoguchi R1, Matsui Y, Mouri K.
- Journal Title
  
  European Journal of Immunology
  
  Volume: 45 Issue: 3 Pages: 893-902
- DOI
  10.1002/eji.201445086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860325
[Journal Article] Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.2012
- Author(s)
  Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S
- Journal Title
  
  Immunity
  
  Volume: 36 Pages: 262-75
- Data Source
  KAKENHI-PROJECT-23790549
[Presentation] Single-cell RNA sequencing analysis reveals heterogeneity of memory CD8 T cells and unbiased impact of MHC class II-deficiency on memory CD8 T cell subpopulations2021
- Author(s)
  Ruka Setoguchi
- Organizer
  Kyoto T cell Conference
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] Single-cell RNA sequencing analysis reveals heterogeneity of memory CD8 T cells and unbiased impact of MHC class II-deficiency on memory CD8 T cell subpopulations2021
- Author(s)
  Ruka Setoguchi
- Organizer
  免疫学会
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] Chronic interferon-γ stimulation impairs memory CD8 T cell maintenance2020
- Author(s)
  Ruka Setoguchi
- Organizer
  学友会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] 持続的なIFN-gammaシグナルはメモリーCD8T細胞の恒常性破綻を誘導する2019
- Author(s)
  瀬戸口　留可
- Organizer
  第28回東京免疫フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] 持続的なIFN-gammaシグナルはメモリーCD8T細胞の恒常性破綻を誘導する2019
- Author(s)
  瀬戸口　留可
- Organizer
  Kyoto T cell Conference
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] Chronic IFN-gamma signals impair memory CD8 T cell maintenance2019
- Author(s)
  Ruka Setoguchi
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] Impaired maintenance of memory CD8 T cells in MHC class II-deficient mice is caused by inflammation but not CD4 T cell-deficiency2018
- Author(s)
  瀬戸口　留可
- Organizer
  Kyoto T cell Conference
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] Chronic IFN-g stimulation impairs memoryCD8 T cell maintenance2018
- Author(s)
  瀬戸口　留可
- Organizer
  第４7回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07051
[Presentation] How MHC class II molecules promote memory CD8 T cell homeostasis2012
- Author(s)
  Ruka Setoguchi, Shohei Hori, Michael J. Bevan
- Organizer
  京都和順会館第22回 Kyoto T cell Conference
- Place of Presentation
  京都和順会館
- Year and Date
  2012-07-07
- Data Source
  KAKENHI-PROJECT-23790549
[Presentation] How MHC class II molecules promote memory CD8 T cell homeostasis2012
- Author(s)
  瀬戸口　留可
- Organizer
  Kyoto T cell Conference
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790549
[Presentation] クロマチンリモデリング因子 Brg1 による CD8T 細胞の増殖および IFN-gamma 産生の制御2011
- Author(s)
  瀬戸口留可
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23790549
[Presentation] クロマチンリモデリング因子Brg1によるCD8T細胞の増殖およびIFN-gamma産生の制御2011
- Author(s)
  瀬戸口　留可
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ、千葉
- Data Source
  KAKENHI-PROJECT-23790549

Setoguchi Ruka 瀬戸口 留可

SETOGUCHI Ruka 瀬戸口 留可

Research Projects

Research Products

MHCクラスIIによる新規自己指向性免疫制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating a novel MHC class II-dependent mechanism which maintains the homeostasis of memory CD8 T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the molecular basis of memory CD8+ T cell maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

How MHC class II molecules promote memory CD8 T cell homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 「メモリーCD8T細胞の恒常性維持メカニズム」免疫記憶の制御と疾患治療2011

Author(s)

Publisher

Data Source

[Book] 免疫記憶の制御と疾患治療2011

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] mTOR signaling promotes a robust and continuous production of IFN-γ by human memory CD8+ T cells and their proliferation2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.2012

Author(s)

Journal Title

Data Source

[Presentation] Single-cell RNA sequencing analysis reveals heterogeneity of memory CD8 T cells and unbiased impact of MHC class II-deficiency on memory CD8 T cell subpopulations2021

Author(s)

Organizer

Data Source

[Presentation] Single-cell RNA sequencing analysis reveals heterogeneity of memory CD8 T cells and unbiased impact of MHC class II-deficiency on memory CD8 T cell subpopulations2021

Author(s)

Organizer

Data Source

[Presentation] Chronic interferon-γ stimulation impairs memory CD8 T cell maintenance2020

Author(s)

Organizer

Data Source

[Presentation] 持続的なIFN-gammaシグナルはメモリーCD8T細胞の恒常性破綻を誘導する2019

Author(s)

Organizer

Data Source

[Presentation] 持続的なIFN-gammaシグナルはメモリーCD8T細胞の恒常性破綻を誘導する2019

Author(s)

Organizer

Data Source

[Presentation] Chronic IFN-gamma signals impair memory CD8 T cell maintenance2019

Author(s)

Organizer

Data Source

[Presentation] Impaired maintenance of memory CD8 T cells in MHC class II-deficient mice is caused by inflammation but not CD4 T cell-deficiency2018

Author(s)

Organizer

Data Source

[Presentation] Chronic IFN-g stimulation impairs memoryCD8 T cell maintenance2018

Setoguchi Ruka 瀬戸口留可

SETOGUCHI Ruka 瀬戸口留可