SAKAMOTO Kazuhiko 坂本和彦

Researcher Number	50420526
Affiliation (based on the past Project Information) *help	2016 – 2019: 山口大学, 医学部附属病院, 講師 2014 – 2015: 山口大学, 医学(系)研究科(研究院), 助教 2008 – 2013: 山口大学, 医学部附属病院, 助教 2007 – 2008: 山口大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator Digestive surgery
Keywords	Principal Investigator サイトカイン / 遺伝子多型 / 副作用予測 / 抗癌剤 / 副作用 / 化学療法 / 手術 / 術後合併症 Except Principal Investigator 化学療法 / 大腸癌 … More / UGT1A1 / イリノテカン / 遺伝子多型 / microRNA / 癌微小環境 / 肝転移 / miRNA / 癌間質 / バイオマーカー / SPARC / nab-paclitaxel / 胃癌 / EGFR / P13K / cetuximab / Cetuximab / UGT1As / Irinotecan / PI3K / BRAF / KRAS / セツキシマブ / α-1-antitripsin / 血清マーカー / 早期診断マーカー / 発癌関連蛋白質 / プロテオーム解析 / 膵癌 / ^6 / ^28 / 6 / 28 / UGT1Ai / 毒性 Less

Analysis of microRNA in cancer microenvironment involved in colorectal liver metastasis
- Principal Investigator
  
  IIDA Michihisa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yamaguchi University
Development of prediction system for chemotherapy-induced side effects based on cytokine gene polymorphismPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Kazuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Yamaguchi University
Biomarker-based prediction of effectiveness of chemotherapy in gastric cancer via SPARC expression profile
- Principal Investigator
  
  YOSHINO Shigefumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yamaguchi University
Development of prediction system of risk of postoperative complications based on cytokine gene polymorphismsPrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Kazuhiko
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Yamaguchi University
Novel strategy for prediction of toxicity and efficacy of chemotherapy for patients with metastatic colorectal cancer.
- Principal Investigator
  
  HAZAMA Shoichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yamaguchi University
Screening for carcinogenesis-related proteins and diagnostic markers of pancreatic cancer by proteomic analysis
- Principal Investigator
  
  YOSHINO Shigefumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yamaguchi University
The polymorphisms can predict the adverse effects of chemotherapy in patients with colorectal cancer
- Principal Investigator
  
  HAZAMA Shoichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yamaguchi University

All 2018 2017 2015 2013 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Overexpression of miR221 and miR222 in the cancer stroma is associated with malignant potential in colorectal cancer2018
- Author(s)
  Iida Michihisa、Hazama Shoichi、Tsunedomi Ryouichi、Tanaka Hironori、Takenouchi Hiroko、Kanekiyo Shinsuke、Tokumitsu Yukio、Tomochika Shinobu、Tokuhisa Yoshihiro、Sakamoto Kazuhiko、Suzuki Nobuaki、Takeda Shigeru、Ueno Tomio、Yamamoto Shigeru、Yoshino Shigefumi、Fujita Koji、Kuroda Masahiko、Nagano Hiroaki
- Journal Title
  
  Oncology Reports
  
  Volume: 40 Pages: 1621-1631
- DOI
  10.3892/or.2018.6575
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10635, KAKENHI-PROJECT-18K08618, KAKENHI-PROJECT-18K08646, KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-16K10574, KAKENHI-PROJECT-17K16558
[Journal Article] Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer2017
- Author(s)
  Kazuhiko Sakamoto
- Journal Title
  
  MOLECULAR AND CLINICAL ONCOLOGY
  
  Volume: 6 Issue: 1 Pages: 125-129
- DOI
  10.3892/mco.2016.1081
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461912, KAKENHI-PROJECT-15K10102
[Journal Article] Cediranib in combination with mFOLFOX6 in Japanese patients with metastatic colorectal cancer : results from the randomised phase II part of a phase I/ II study2011
- Author(s)
  Kato T, Muro K, Yamaguchi K, Bando H, Hazama S, Amagai K, Baba H, Denda T, Shi X, Fukase K, Sakamoto J, Mishima H
- Journal Title
  
  Ann Oncol
  
  Volume: 23(4): 933-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591725
[Journal Article] Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 28/ 6 polymorphisms2011
- Author(s)
  Okuyama Y, Hazama S, Nozawa H, Kobayashi M, Takahashi K, Fujikawa K, Kato T, Nagata N, Kimura H, Oba K, Sakamoto J, Mishima H
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 41(4): 477-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591725
[Journal Article] The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues2010
- Author(s)
  Okayama N, Nishioka M, Hazama S, Sakai K, Suehiro Y, Maekawa M, Sakamoto J, Iwamoto S, Kato T, Mishima H, Oka M, Hinoda Y
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 41(2): 165-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591725
[Journal Article] UGT1A1 *6 is a predictive marker of severe neutropenia for metastatic CRC patients received FOLFIRI in JAPAN2008
- Author(s)
  S. Hazama, Y. Okuyama, T. Kato, K. Takahashi, H. Nozawa, N. Okayama, Y. Hinoda, M. Oka, J. Sakamoto, H. Mishima
- Journal Title
  
  Annals of Oncology 19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591545
[Presentation] 食道癌化学療法の有害事象とサイトカイン遺伝子多型との関連2015
- Author(s)
  坂本和彦
- Organizer
  日本消化器外科学会
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26461912
[Presentation] 血清サイトカイン値からみた腹腔鏡下肝切除の有用性2015
- Author(s)
  坂本和彦
- Organizer
  日本外科学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26461912
[Presentation] サイトカイン遺伝子多型による食道癌術後肺炎の術前予測システムの開発2013
- Author(s)
  坂本和彦
- Organizer
  外科侵襲とサイトカイン研究会
- Place of Presentation
  群馬県　伊香保温泉
- Data Source
  KAKENHI-PROJECT-24791379
[Presentation] 食道癌術後肺炎のリスクとサイトカイン遺伝子多型との関連2013
- Author(s)
  坂本和彦
- Organizer
  Japan Digestive Disease Week 2013
- Place of Presentation
  東京都　高輪グランドプリンスホテル
- Data Source
  KAKENHI-PROJECT-24791379
[Presentation] 食道癌術後肺炎のリスクとサイトカイン遺伝子多型との関連2013
- Author(s)
  坂本和彦
- Organizer
  Japan Digestive Disease Week2013
- Place of Presentation
  高輪グランドプリンスホテル(東京)
- Data Source
  KAKENHI-PROJECT-24791379
[Presentation] サイトカイン遺伝子多型による食道癌術後肺炎の術前予測システムの開発2013
- Author(s)
  坂本和彦
- Organizer
  外科侵襲とサイトカイン研究会
- Place of Presentation
  伊香保温泉(群馬)
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-24791379
[Presentation] 大腸がん治療新時代Personalized Therapyの現状と今後UGT1As遺伝子多型で予測するIrinotecanの毒性と効果2010
- Author(s)
  硲彰一, 日野田裕治, 三嶋秀行, 坂本純一, 岡正朗
- Organizer
  日本癌治療学会
- Place of Presentation
  京都国立京都国際会館
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21591725
[Presentation] UGTIA多型の遺伝子型サブセット選択はFOLFIRI投与mCRC患者の毒性及び腫瘍反応性を予測する(Genotype subset selection of UGTIAs polymorphisms can predict toxicity and tumor response of mCRC pts received FOLFIRI)(英語)2009
- Author(s)
  硲彰一, 日野田裕治, 岡山直子, 浜本義彦, 藤田悠介, 三嶋秀行, 坂本純一, 岡正朗
- Organizer
  日本癌学会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21591725
[Presentation] 消化器癌化学療法の効果予測(抗癌剤感受性試験など)新しい遺伝子多型解析による大腸癌化学療法(FOLFIRI)の効果予測システムの開発2009
- Author(s)
  硲彰一, 三嶋秀行, 加藤健志, 高橋賢一, 野澤寛, 木村文彦, 安藤秀明, 小林道也, 坂本純一, 岡正朗
- Organizer
  日本臨床外科学会
- Place of Presentation
  京都国立京都国際会館
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-21591725
[Presentation] UGT1A1 *6 is a predictive marker of severe neutropenia for metastatic CRC patients received FOLFIRI in JAPAN2008
- Author(s)
  S. Hazama, Y. Okuyama, T. Kato, K. Takahashi, H. Nozawa, N. Okayama, Y. Hinoda, M. Oka, J. Sakamoto, H. Mishima
- Organizer
  The 33rd ESMO (European society of medical oncology) Congress
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-19591545
[Presentation] 食道癌化学療法の有害事象とサイトカイン遺伝子多型との関連
- Author(s)
  坂本和彦
- Organizer
  日本消化器外科学会
- Place of Presentation
  アクトシティ浜松(静岡県浜松市）
- Year and Date
  2015-07-15 – 2015-07-17
- Data Source
  KAKENHI-PROJECT-26461912

1. HAZAMA Shoichi (50253159)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. OKAYAMA Naoko (40420541)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. YOSHINO Shigefumi (60294633)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAMESA Akuo (30359905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FUJITA Yusuke (40509527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IIDA Michihisa (50554797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 鈴木伸明 (50526910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

SAKAMOTO Kazuhiko 坂本 和彦

Research Projects

Research Products

Co-Researchers

Analysis of microRNA in cancer microenvironment involved in colorectal liver metastasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of prediction system for chemotherapy-induced side effects based on cytokine gene polymorphismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biomarker-based prediction of effectiveness of chemotherapy in gastric cancer via SPARC expression profile

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of prediction system of risk of postoperative complications based on cytokine gene polymorphismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel strategy for prediction of toxicity and efficacy of chemotherapy for patients with metastatic colorectal cancer.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening for carcinogenesis-related proteins and diagnostic markers of pancreatic cancer by proteomic analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The polymorphisms can predict the adverse effects of chemotherapy in patients with colorectal cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Overexpression of miR221 and miR222 in the cancer stroma is associated with malignant potential in colorectal cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of tumor necrosis factor-α polymorphism with chemotherapy-induced oral mucositis in patients with esophageal cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cediranib in combination with mFOLFOX6 in Japanese patients with metastatic colorectal cancer : results from the randomised phase II part of a phase I/ II study2011

Author(s)

Journal Title

Data Source

[Journal Article] Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 28/ 6 polymorphisms2011

Author(s)

Journal Title

Data Source

[Journal Article] The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues2010

Author(s)

Journal Title

Data Source

[Journal Article] UGT1A1 *6 is a predictive marker of severe neutropenia for metastatic CRC patients received FOLFIRI in JAPAN2008

Author(s)

Journal Title

Data Source

[Presentation] 食道癌化学療法の有害事象とサイトカイン遺伝子多型との関連2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 血清サイトカイン値からみた腹腔鏡下肝切除の有用性2015

Author(s)

SAKAMOTO Kazuhiko 坂本和彦

[Presentation] サイトカイン遺伝子多型による食道癌術後肺炎の術前予測システムの開発2013