Yamakoshi Kimi 山越貴水

… Alternative Names

YAMAKOSHI Kimi 山越貴水

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Researcher Number	50423398
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所メディカルゲノムセンター, 研究員
Affiliation (based on the past Project Information) *help	2022: 国立研究開発法人国立長寿医療研究センター, メディカルゲノムセンター, 研究員 2022: 国立研究開発法人国立長寿医療研究センター, 研究所研究推進基盤センター, 研究員 2021: 国立研究開発法人国立長寿医療研究センター, 研究推進基盤センター, 研究員 2018 – 2020: 国立研究開発法人国立長寿医療研究センター, 老化機構研究部, 室長 2017: 国立研究開発法人国立長寿医療研究センター, 老化機構研究部・代謝研究室, 室長 … More 2016: 国立研究開発法人国立長寿医療研究センター, 老化機構研究部, 室長 2011 – 2013: 独立行政法人国立長寿医療研究センター, 老化機構研究部, 室長 2009 – 2010: Japanese Foundation For Cancer Research, 癌研究所がん生物部, 研究員 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 59040:Nutrition science and health science-related / Biological Sciences / Carcinogenesis
Keywords	Principal Investigator p16 / ムチン / 糖鎖 / 顎下腺 / 癌抑制遺伝子 / 唾液腺 / ドライマウス / O-グリカン / 曵糸性 / 唾液粘性 … More / 炎症 / 唾液粘度 / 口腔乾燥症状 / 老化 / 細胞・組織 / 遺伝子 / 癌 / がん / 成体幹細胞 / Bmi-1 / 加齢 / p53 / p16^<INK4a> / 発癌ストレス / 肥満 / P16 / 皮膚化学発癌 / エピジェネティクス / インビボ・イメージング / 分子腫瘍学 Less

Elucidation of the mechanism of xerostomia occurrence by glycan profilingPrincipal Investigator
- Principal Investigator
  
  YAMAKOSHI Kimi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
The role of O-glycan in tumor suppressionPrincipal Investigator
- Principal Investigator
  
  YAMAKOSHI Kimi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
幹細胞老化の制御機構とその破綻による上皮管腔組織機能低下メカニズムの解明Principal Investigator
- Principal Investigator
  
  山越貴水
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Center for Geriatrics and Gerontology
Mechanisms of oncogenic stress evolution caused by obesityPrincipal Investigator
- Principal Investigator
  
  YAMAKOSHI Kimi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  National Center for Geriatrics and Gerontology
Analysis of silencing mechanism of INK4A gene expression during tumorigenesis with in vivo imaging systemPrincipal Investigator
- Principal Investigator
  
  YAMAKOSHI Kimi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Japanese Foundation For Cancer Research

All 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 糖鎖制御異常を介したポリコーム蛋白質のがん促進機構2017
- Author(s)
  山越　貴水
- Total Pages
  4
- Publisher
  日本基礎老化学会会誌
- Data Source
  KAKENHI-PROJECT-16K08636
[Book] がん－疾患モデルの作製と利用2012
- Author(s)
  山越貴水
- Total Pages
  7
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PUBLICLY-24112528
[Book] 細胞周期制御遺伝子-1(p16^<INK4a>およびp53)がん-疾患モデルの作製と利用2012
- Author(s)
  山越貴水, 原英二
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-23701040
[Book] がんー疾患モデルの作製と利用2012
- Author(s)
  山越貴水
- Total Pages
  7
- Publisher
  株式会社エル・アイ・シー
- Data Source
  KAKENHI-PROJECT-23701040
[Book] インビボイメージングによる細胞老化誘導遺伝子p16^<INK4a>及びp53の機能解析、モデル動物利用マニュアル(仮題)2011
- Author(s)
  山越貴水、原英二
- Publisher
  発刊予定
- Data Source
  KAKENHI-PROJECT-21790332
[Book] がん幹細胞-ステムネス, ニッチ, 標的治療への理解細胞老化 : 老化とがん化の接点実験医学,Vol.29 No.20(増刊)2011
- Author(s)
  山越貴水, 高橋暁子, 原英二
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23701040
[Book] 実験医学2011
- Author(s)
  山越貴水, 高橋暁子, 原英二.
- Total Pages
  7
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-23701040
[Book] モデル動物利用マニュアル2011
- Author(s)
  山越貴水
- Publisher
  株式会社エル・アイ・シー(仮題発刊予定)
- Data Source
  KAKENHI-PROJECT-21790332
[Book] Medical Science Digest2010
- Author(s)
  山越貴水
- Total Pages
  4
- Publisher
  ニュー・サイエンス社
- Data Source
  KAKENHI-PROJECT-21790332
[Journal Article] Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.2021
- Author(s)
  Kameyama, A., Nishijima, R., Yamakoshi, K
- Journal Title
  
  PLoS One
  
  Volume: 16 Issue: 1 Pages: e0245607-e0245607
- DOI
  10.1371/journal.pone.0245607
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11785, KAKENHI-PROJECT-16H06277
[Journal Article] Alteration of mucins in the submandibular gland during aging in mice.2021
- Author(s)
  Kameyama, A., Thet Tin, WW., Nishijima, R., Yamakoshi, K.
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 121 Pages: 104967-104967
- DOI
  10.1016/j.archoralbio.2020.104967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11785, KAKENHI-PROJECT-16H06277
[Journal Article] A rapid separation and characterization of mucins from mouse submandibular glands by supported molecular matrix electrophoresis2019
- Author(s)
  Kameyama Akihiko、Yamakoshi Kimi、Watanabe Atsushi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: 1867 Issue: 1 Pages: 76-81
- DOI
  10.1016/j.bbapap.2018.05.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19627, KAKENHI-PROJECT-16K08636
[Journal Article] 分子マトリックス電気泳動で解明する唾液腺ムチンの老化に伴う変化2019
- Author(s)
  亀山昭彦, 松野裕樹, 飯田真由, 丸山光生, 渡邉淳, 山越貴水
- Journal Title
  
  電気泳動
  
  Volume: 63 Pages: 55-61
- NAID
  130007669334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11785
[Journal Article] A sialo-oligosaccharide-rich mucin-like molecule specifically detected in the submandibular glands of aged mice.2019
- Author(s)
  Iida, M., Matsuno, YK., Watanabe, A., Maruyama, M., Kameyama, A., Yamakoshi, K.
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 12 Pages: 52-58
- DOI
  10.1016/j.archoralbio.2018.10.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08636
[Journal Article] Expression of Ror2 Associated with Fibrosis of the Submandibular Gland2017
- Author(s)
  Takahashi, D., Suzuki, H., Kakei, Y., Yamakoshi, K., Minami, Y., Komori, T., Nishita, M.
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 42 Issue: 2 Pages: 159-167
- DOI
  10.1247/csf.17019
- NAID
  130006258840
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08636, KAKENHI-PROJECT-17K08634, KAKENHI-PROJECT-16H05152
[Journal Article] 細胞老化と慢性炎症2016
- Author(s)
  山越　貴水
- Journal Title
  
  日本老年医学会雑誌
  
  Volume: 53 Pages: 88-94
- Data Source
  KAKENHI-PROJECT-16K08636
[Journal Article] Critical role of Frizzledl in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation.2014
- Author(s)
  Doi R, Endo M, Yamakoshi K, Y amanashi Y, Nishita M, Fukada SI. Minami Y.
- Journal Title
  
  Genes Cells.
  
  Volume: 19 Issue: 4 Pages: 287-296
- DOI
  10.1111/gtc.12132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11J01138, KAKENHI-PLANNED-23112007, KAKENHI-PUBLICLY-24112528, KAKENHI-PROJECT-24390080, KAKENHI-PUBLICLY-25110711, KAKENHI-PROJECT-25460367, KAKENHI-PROJECT-25702044
[Journal Article] Visualizing the dynamics of senescence stress response in living animals2012
- Author(s)
  Yamakoshi, K., Hara, E.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 32 Issue: 1 Pages: 032-038
- DOI
  10.2492/inflammregen.32.032
- NAID
  130004482290
- ISSN
  1880-8190, 1880-9693
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701040
[Journal Article] Visualizing the dynamics of senescence stress response in living animals.2012
- Author(s)
  Yamakoshi, K. & Hara, E.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 32(1) Pages: 32-38
- NAID
  130004482290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701040
[Journal Article] DNA damage signaling triggers degradation of histone methyltransferases through APC/CCdh1 in senescent cells.2012
- Author(s)
  Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H., Hara, E.
- Journal Title
  
  Molecular Cell
  
  Volume: 45(1) Pages: 123-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701040
[Journal Article] Real-time in vivo imaging of p16 gene expression : a new approach to study senescence stress signaling in living animals.2010
- Author(s)
  Ohtani, N., Yamakoshi, K., Takahashi, A., Hara, E.
- Journal Title
  
  Cell.Div. 14,5
  
  Pages: 1-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790332
[Journal Article] 細胞老化研究の最前線2010
- Author(s)
  山越貴水、原英二
- Journal Title
  
  メディカル・サイエンス・ダイジェスト Vol.36
- Data Source
  KAKENHI-PROJECT-21790332
[Journal Article] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010
- Author(s)
  Takeuchi, S., Takahashi, A., Motoi, N., Yoshimoto, S., Tajima, T., Yamakoshi, K., Hirao, A., Yanagi, S., Fukami, K., Ishikawa, Y., Sone, S., Hara, E., Ohtani, N.
- Journal Title
  
  Cancer Res. 15,70(22)
  
  Pages: 9381-9390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790332
[Journal Article] Real-time in vivo imaging of p16^<INK4a> reveals cross talk with p53.2009
- Author(s)
  Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, DJ., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N., Hara, E.
- Journal Title
  
  J.Cell Biol. 10,186(3)
  
  Pages: 393-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790332
[Journal Article] Real-time in vivo imaging of p16^<INK4a> reveals cross talk with p532009
- Author(s)
  Kimi Yamakoshi
- Journal Title
  
  The Journal of Cell Biology 186
  
  Pages: 393-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790332
[Presentation] Analyses of mucins in submandibular gland during aging in mice2020
- Author(s)
  Yamakoshi K, Kameyama A, Nishijima R, Maruyama M
- Organizer
  第43回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-19K11785
[Presentation] Analyses of mucins in submandibular gland during aging in mice2020
- Author(s)
  Yamakoshi K, Kameyama A, Nishijima R, Maruyama M.
- Organizer
  第71回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K11785
[Presentation] ポリコームタンパク質Bmi-1による顎下腺ムチン糖鎖構造の制御2019
- Author(s)
  山越貴水、亀山昭彦、西島里咲、飯田万由、丸山光生
- Organizer
  第42回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-19K11785
[Presentation] ポリコーム蛋白質Bmi-1による顎下腺ムチン糖鎖構造の制御2019
- Author(s)
  山越貴水、亀山昭彦、西島里咲、飯田万由、丸山光生
- Organizer
  第13回日本エピジェネティクス研究会
- Data Source
  KAKENHI-PROJECT-19K11785
[Presentation] ポリコームタンパク質Bmi1による顎下腺ムチン糖鎖構造の制御2019
- Author(s)
  山越　貴水、亀山　昭彦、西島　里咲、飯田　万由、丸山　光生
- Organizer
  第42回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-16K08636
[Presentation] A sialo-oligosaccharides rich mucin-like molecule is specifically detected in the submandibular glands of aged mice.2018
- Author(s)
  Iida M, Matsuno Y, Watanabe A, Maruyama M, Kameyama A, Yamakoshi K.
- Organizer
  第41回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-16K08636
[Presentation] Bmi-1 controls cancer cell motility and invasion through the glycosyltransferase C2GnT2.2018
- Author(s)
  Yamakoshi K, Iida M, Nishijima R, Kameyama A, Maruyama M.
- Organizer
  International Cell Senescence Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08636
[Presentation] Bmi-1 controls cancer cell motility and invasion through the glycosyltransferase C2GnT2.2017
- Author(s)
  Yamakoshi, K., Iida, M., Kimura, H., Kameyama, A., Maruyama, M.
- Organizer
  Keystone Symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08636
[Presentation] Bmi-1 controls cancer cell motility and invasion through the glycosyltransferase C2GnT2.2017
- Author(s)
  Yamakoshi, K., Iida, M., Kimura, H., Kameyama, A., Maruyama, M.
- Organizer
  Gordon Research Conferences (Aging)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08636
[Presentation] Bmi-1 controls cancer cell motility and invasion through the glycosyltransferase C2GnT22017
- Author(s)
  Yamakoshi, K., Iida, M., Kimura, H., Kameyama, A., Maruyama, M.
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-16K08636
[Presentation] The role of p16 in the age-related functional decline of the submandibular gland.2014
- Author(s)
  Iida M, Katano S, Kimura H, Maruyama M, Yamakoshi K.
- Organizer
  第37回日本基礎老化学会大会
- Place of Presentation
  愛知
- Data Source
  KAKENHI-PUBLICLY-24112528
[Presentation] p16^<Ink4a> contributes to the age-dependent fate of stem/ progenitor cells in the submandibular gland.2013
- Author(s)
  Satoshi Katano, Hiromi Kimura, Naoko Ohtani, Eiji Hara, Mitsuo Maruyama, Kimi Yamakoshi
- Organizer
  Gordon Research Conferences Salivary Glands & Exocrine Biology
- Place of Presentation
  米国テキサス州ガルベストン市
- Data Source
  KAKENHI-PROJECT-23701040
[Presentation] p16Ink4a contributes to the age-dependent fate of stem/ progenitor cells in the submandibular gland.2013
- Author(s)
  Yamakoshi, K.
- Organizer
  Gordon Research Conferences
- Place of Presentation
  米国テキサス州ガルベストン市
- Year and Date
  2013-02-04
- Data Source
  KAKENHI-PUBLICLY-24112528
[Presentation] Role of p16INK4a in the age-related functional decline of the submandibular gland.2012
- Author(s)
  Yamakoshi, K.
- Organizer
  KEYSTONE SYMPOSIA
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-24112528
[Presentation] Backup tumor suppressor role for p16^<INK4a> in the event of p53 inactivation2010
- Author(s)
  山越貴水
- Organizer
  日本分子生物学会年回・日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21790332
[Presentation] Real-time in vivo imaging of p16^<Ink4a> gene expression unveils the dynamics of tumor suppressor network pathway in living animals.2010
- Author(s)
  山越貴水
- Organizer
  The 16th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  Sheraton Miyako Hotel(東京都)
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-21790332
[Presentation] Role of p16^<INK4a> in the age-related functional decline of the submandibular gland.2010
- Author(s)
  Kimi Yamakoshi
- Organizer
  KEYSTONE SYMPOSIA Aging and Diseases of Aging
- Place of Presentation
  東京
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-23701040
[Presentation] Backup tumor suppressor role for p16^<Ink4a> in the event of p53 inactivation.2010
- Author(s)
  Akiko Takahashi, Kimi Yamakoshi, Naoko Ohtani, Eiji Hara.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同学会
- Place of Presentation
  神戸(特別講演)
- Year and Date
  2010-01-02
- Data Source
  KAKENHI-PROJECT-21790332
[Presentation] Real-time In Vivo Imaging of p16^<INK4a> Expression Unveils a Cross-talk between p53 and p16^<INK4a>2009
- Author(s)
  山越貴水
- Organizer
  Mechanisms & Models of Cancer Meeting
- Place of Presentation
  Salk Institute(アメリカ合衆国カリフォルニア州ラ・ホヤ市)
- Year and Date
  2009-08-14
- Data Source
  KAKENHI-PROJECT-21790332
[Presentation] Real-time in vivo imaging of p16^<Ink4a> expression unveils a cross-talk between p53 and p16^<Ink4a>.2009
- Author(s)
  Kimi Yamakoshi, Akiko Takahashi, Naoko Ohtani, Eiji Hara.
- Organizer
  2nd Salk Institute, Mechanisms and Models of Cancer meeting
- Place of Presentation
  アメリカ合衆国カリフォルニア州ラ・ホヤ市(一般演題)
- Data Source
  KAKENHI-PROJECT-21790332
[Presentation] The role of p16INK4a in the age-related functional decline of the submandibular gland.
- Author(s)
  Yamakoshi K, Katano S,　Kimura H.
- Organizer
  文部科学省新学術領域研究「上皮管腔組織形成」第１回国際会議
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PUBLICLY-24112528
[Presentation] 加齢過程での顎下腺組織機能低下におけるp16Ink4aの役割
- Author(s)
  山越貴水, 片野諭, 木村広美, 丸山光生, van Louizen M.
- Organizer
  第６５回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-24112528
[Presentation] 唾液腺機能の制御機構と老化
- Author(s)
  山越　貴水
- Organizer
  第56回日本老年医学会学術集会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PUBLICLY-24112528
[Presentation] The role of p16 in the age-related functional decline of the submandibular gland.
- Author(s)
  Yamakoshi K.
- Organizer
  平成２５年度文部科学省新学術領域研究　公開シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-24112528

1. KAMEYAMA Akihiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

Yamakoshi Kimi 山越 貴水

YAMAKOSHI Kimi 山越 貴水

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of xerostomia occurrence by glycan profilingPrincipal Investigator

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The role of O-glycan in tumor suppressionPrincipal Investigator

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幹細胞老化の制御機構とその破綻による上皮管腔組織機能低下メカニズムの解明Principal Investigator

Principal Investigator

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Mechanisms of oncogenic stress evolution caused by obesityPrincipal Investigator

Principal Investigator

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Analysis of silencing mechanism of INK4A gene expression during tumorigenesis with in vivo imaging systemPrincipal Investigator

Principal Investigator

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[Book] 糖鎖制御異常を介したポリコーム蛋白質のがん促進機構2017

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[Book] がん－疾患モデルの作製と利用2012

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[Book] 細胞周期制御遺伝子-1(p16^<INK4a>およびp53)がん-疾患モデルの作製と利用2012

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[Book] がんー疾患モデルの作製と利用2012

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[Book] インビボイメージングによる細胞老化誘導遺伝子p16^<INK4a>及びp53の機能解析、モデル動物利用マニュアル(仮題)2011

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[Book] がん幹細胞-ステムネス, ニッチ, 標的治療への理解細胞老化 : 老化とがん化の接点実験医学,Vol.29 No.20(増刊)2011

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[Book] 実験医学2011

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[Book] モデル動物利用マニュアル2011

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[Book] Medical Science Digest2010

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[Journal Article] Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.2021

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DOI

Yamakoshi Kimi 山越貴水

YAMAKOSHI Kimi 山越貴水