Murata Miyuki 村田美幸

… Alternative Names

村田美幸ムラタミユキ

伊藤美幸

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Researcher Number	50423752
Other IDs
Affiliation (Current)	2025: 北海道大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 北海道大学, 医学研究院, 助教 2018 – 2022: 北海道大学, 医学研究院, 特任助教 2017: 北海道大学, 医学(系)研究科(研究院), 特任助教 2011: Hokkaido University, 医学(系)研究科(研究院), その他 2010: 北海道大学, 大学院・医学研究科, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology Except Principal Investigator Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator アクロレイン / 糖尿病網膜症 / 加齢黄斑変性 / タイトジャンクション / 網膜色素上皮 / 炎症 / 網膜グリア細胞 / HMGB1 / MCP-1 / VAP-1 … More / 酸化ストレス / 眼細胞生物学 / 上皮間葉移行 / 網膜 / 眼科学 … More Except Principal Investigator アクロレイン / 滲出型加齢黄斑変性 / αシヌクレイン / 網膜色素上皮細胞 / 網膜色素上皮 / LRRK2 / パーキンソン病 / 加齢黄斑変性 / 病理学 / 上皮間葉移行 / ミュラー細胞 / αBークリスタリン / Glycol-AGE / 網膜神経病態 / Glycer-AGE / 糖尿病網膜症 Less

滲出型加齢黄斑変性の網膜色素上皮障害における毒性アルデヒドアクロレインの関与Principal Investigator
- Principal Investigator
  
  村田美幸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Hokkaido University
Role of alphaB-crystallin in epithelial-mesenchymal transition in retinal Muller cells
- Principal Investigator
  
  加瀬諭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Hokkaido University
Inflammation-inducing mechanism of acrolein in the pathogenesis of diabetic retinopathyPrincipal Investigator
- Principal Investigator
  
  Murata Miyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Hokkaido University
加齢黄斑変性におけるセリン/スレオニンキナーゼLRRK2の病態意義解明
- Principal Investigator
  
  野田航介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Hokkaido University
Elucidation of the Mechanism of Retinal Neuropathology by Glycer-AGE and Drug Discovery for Diabetic Retinopathy
- Principal Investigator
  
  Ishida Susumu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Hokkaido University
Mechanism of acrolein generation in diabetic retinopathyPrincipal Investigator
- Principal Investigator
  
  Murata Miyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Hokkaido University
網膜色素上皮細胞における上皮間葉移行関連転写因子の探索Principal Investigator
- Principal Investigator
  
  村田美幸 (伊藤美幸)
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Hokkaido University

All 2023 2022 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Muller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation2023
- Author(s)
  Yamamoto Taku、Kase Satoru、Shinkai Akihiro、Murata Miyuki、Kikuchi Kasumi、Wu Di、Kageyama Yasushi、Shinohara Masami、Sasase Tomohiko、Ishida Susumu
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 64 Issue: 10 Pages: 20-20
- DOI
  10.1167/iovs.64.10.20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15902, KAKENHI-PROJECT-21K09667, KAKENHI-PROJECT-21K09668, KAKENHI-PROJECT-20H03837
[Journal Article] Placental growth factor stabilizes VEGF receptor-2 protein in retinal pigment epithelial cells by downregulating glycogen synthase kinase 3 activity2022
- Author(s)
  Murata Miyuki、Noda Kousuke、Kase Satoru、Hase Keitaro、Wu Di、Ando Ryo、Ishida Susumu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 9 Pages: 102378-102378
- DOI
  10.1016/j.jbc.2022.102378
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09667, KAKENHI-PROJECT-21K09668, KAKENHI-PROJECT-20H03837, KAKENHI-PROJECT-23K21479
[Journal Article] ROCK1 Mediates Retinal Glial Cell Migration Promoted by Acrolein2021
- Author(s)
  Fukutsu Kanae、Murata Miyuki、Kikuchi Kasumi、Yoshida Shiho、Noda Kousuke、Ishida Susumu
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 8 Pages: 717602-717602
- DOI
  10.3389/fmed.2021.717602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09667, KAKENHI-PROJECT-20H03837, KAKENHI-PROJECT-23K21479
[Journal Article] Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration2019
- Author(s)
  Murata Miyuki、Noda Kousuke、Yoshida Shiho、Saito Michiyuki、Fujiya Akio、Kanda Atsuhiro、Ishida Susumu
- Journal Title
  
  Investigative Opthalmology & Visual Science
  
  Volume: 60 Issue: 13 Pages: 4425-4435
- DOI
  10.1167/iovs.19-27346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09393, KAKENHI-PROJECT-19K09944, KAKENHI-PROJECT-16H05484, KAKENHI-PROJECT-17K11442, KAKENHI-PROJECT-17K11444
[Journal Article] Proteolytic cleavage of vascular adhesion protein-1 induced by vascular endothelial growth factor in retinal capillary endothelial cells2018
- Author(s)
  Yoshida Shiho、Murata Miyuki、Noda Kousuke、Matsuda Takashi、Saito Michiyuki、Saito Wataru、Kanda Atsuhiro、Ishida Susumu
- Journal Title
  
  Jpn J Ophthalmol.
  
  Volume: 62 Issue: 2 Pages: 256-264
- DOI
  10.1007/s10384-017-0555-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10855, KAKENHI-PROJECT-17K11442, KAKENHI-PROJECT-17K11444, KAKENHI-PROJECT-18K09393, KAKENHI-PROJECT-16H05484, KAKENHI-PROJECT-16K11279
[Journal Article] Vascular Adhesion Protein-1 Blockade Suppresses Ocular Inflammation After Retinal Laser Photocoagulation in Mice2017
- Author(s)
  Matsuda Takashi、Noda Kousuke、Murata Miyuki、Kawasaki Akiko、Kanda Atsuhiro、Mashima Yukihiko、Ishida Susumu
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 58 Issue: 7 Pages: 3254-3261
- DOI
  10.1167/iovs.17-21555
- NAID
  120006337769
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11442, KAKENHI-PROJECT-17K11444, KAKENHI-PROJECT-15K10855
[Journal Article] Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy2017
- Author(s)
  Murata Miyuki、Noda Kousuke、Kawasaki Akiko、Yoshida Shiho、Dong Yoko、Saito Michiyuki、Dong Zhenyu、Ando Ryo、Mori Shohei、Saito Wataru、Kanda Atsuhiro、Ishida Susumu
- Journal Title
  
  Curr Eye Res
  
  Volume: 42 Issue: 12 Pages: 1674-1683
- DOI
  10.1080/02713683.2017.1359847
- NAID
  120006540056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11442, KAKENHI-PROJECT-17K11444, KAKENHI-PROJECT-15K10855, KAKENHI-PROJECT-15K20241
[Presentation] 網膜色素上皮細胞におけるleucine-richrepeat kinase2 過剰発現の影響2023
- Author(s)
  水門由佳、村田美幸、野田航介、石田晋
- Organizer
  第127回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-23K21479
[Presentation] Leucine-rich repeat kinase 2 のキナーゼ活性亢進がマウスの網膜機能に及ぼす影響2023
- Author(s)
  村田美幸、水門由佳、野田航介、西村萌美、横井康一、吉田志帆、石田晋
- Organizer
  第43回日本眼薬理学会総会
- Data Source
  KAKENHI-PROJECT-23K21479
[Presentation] Retinal capillary changes and cytokine expression in Spontaneously Diabetic Torii fatty rats2022
- Author(s)
  Kikuchi K, Murata M, Kageyama Y, Shinohara M, Sasase T, Noda K, Ishida S.
- Organizer
  Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03837
[Presentation] Retinal capillary changes and cytokine expression in Spontaneously Diabetic Torii fatty rats2022
- Author(s)
  Kikuchi K, Murata M, Kageyama Y, Shinohara M, Sasase T, Noda K, Ishida S
- Organizer
  Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09667
[Presentation] 増殖糖尿病網膜症におけるマクロファージ遊走とアクロレイン2022
- Author(s)
  福津佳苗、村田美幸、菊地香澄、野田航介、石田晋
- Organizer
  第25回眼科分子生物学研究会
- Data Source
  KAKENHI-PROJECT-20H03837
[Presentation] Muller細胞におけるアクロレインによる単球走化性因子の発現誘導2022
- Author(s)
  福津佳苗、村田美幸、菊地香澄、吉田志帆、野田航介、石田晋
- Organizer
  第126回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-20H03837
[Presentation] Muller細胞におけるアクロレインによる単球走化性因子の発現誘導2022
- Author(s)
  福津佳苗、村田美幸、菊地香澄、吉田志帆、野田航介、石田晋
- Organizer
  第126回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-21K09667
[Presentation] 増殖糖尿病網膜症におけるマクロファージ遊走とアクロレイン2022
- Author(s)
  福津佳苗、村田美幸、菊地香澄、野田航介、石田晋
- Organizer
  第25回眼科分子生物学研究会
- Data Source
  KAKENHI-PROJECT-21K09667
[Presentation] Acrolein promotes Muller cell migration via ROCK1 pathway2021
- Author(s)
  Fukutsu K, Murata M, Kikuchi K, Yoshida S, Noda K, Ishida S.
- Organizer
  The 14th Joint Meeting of Japan-China-Korea Ophthalmologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21479
[Presentation] Spontaneously Diabetic Torii fatty ラットの網膜血管の解析2021
- Author(s)
  菊地香澄、野田航介、村田美幸、影山靖、篠原雅巳、笹瀬智彦、石田晋
- Organizer
  第27回日本糖尿病眼学会総会
- Data Source
  KAKENHI-PROJECT-20H03837
[Presentation] Acrolein promotes Muller cell migration via ROCK1 pathway2021
- Author(s)
  Fukutsu K, Murata M, Kikuchi K, Yoshida S, Noda K, Ishida S.
- Organizer
  The 14th Joint Meeting of Japan-China-Korea Ophthalmologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03837
[Presentation] Acrolein promotes Muller cell migration via ROCK1 pathway2021
- Author(s)
  Fukutsu K, Murata M, Kikuchi K, Yoshida S, Noda K, Ishida S
- Organizer
  The 14th Joint Meeting of Japan-China-Korea Ophthalmologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09667
[Presentation] Spontaneously Diabetic Torii fatty ラットの網膜血管の解析2021
- Author(s)
  菊地香澄、野田航介、村田美幸、影山靖、篠原雅巳、笹瀬智彦、石田晋.
- Organizer
  日本糖尿病眼学会総会
- Data Source
  KAKENHI-PROJECT-21K09667
[Presentation] Acrolein promotes Muller cell migration via ROCK1 pathway2021
- Author(s)
  Fukutsu K, Murata M, Kikuchi K, Yoshida S, Noda K, Ishida S
- Organizer
  The 14th Joint Meeting of Japan-China-Korea Ophthalmologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03837
[Presentation] Spontaneously Diabetic Torii fatty ラットの網膜血管の解析2021
- Author(s)
  菊地香澄、野田航介、村田美幸、影山靖、篠原雅巳、笹瀬智彦、石田晋
- Organizer
  第27回日本糖尿病眼学会
- Data Source
  KAKENHI-PROJECT-20H03837
[Presentation] Spontaneously Diabetic Torii fatty ラットにおける糖尿病白内障の検討2019
- Author(s)
  菊地香澄、野田航介、村田美幸、田川義晃、神田敦宏、加瀬諭、影山靖、篠原雅巳、笹瀬智彦、石田晋
- Organizer
  第123回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-17K11442
[Presentation] Spontaneously Diabetic Torii fatty ラット網膜における炎症性サイトカインの発現解析2019
- Author(s)
  菊地香澄、野田航介、村田美幸、神田敦宏、加瀬諭、影山靖、篠原雅巳、笹瀬智彦、石田晋
- Organizer
  第25回日本糖尿病眼学会
- Data Source
  KAKENHI-PROJECT-17K11442
[Presentation] Hypoxia aggravates acrolein generation via HIF-1/SMOX pathway in glial cells2019
- Author(s)
  Wu D, Murata M, Noda K, Liu Y, Kanda A, Ishida S.
- Organizer
  第123回日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-17K11442
[Presentation] Hypoxia inducible factor-1 regulates spermine oxidase leading to acrolein generation in Muller Glial cells2019
- Author(s)
  Wu D, Noda K, Murata M, Liu Y, Kanda A and Ishida S.
- Organizer
  Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11442
[Presentation] 網膜グリア細胞の遊走能に対するアクロレインの作用2018
- Author(s)
  村田美幸
- Organizer
  第22回眼科分子生物学研究会
- Data Source
  KAKENHI-PROJECT-17K11442
[Presentation] 網膜色素上皮細胞における胎盤成長因子のアポトーシス抑制効果2018
- Author(s)
  村田美幸、野田航介、長谷敬太郎、神田敦宏、石田晋
- Organizer
  第57回日本網膜硝子体学会
- Data Source
  KAKENHI-PROJECT-17K11442
[Presentation] 増殖糖尿病網膜症患者の硝子体中アクロレイン結合蛋白とCXCL1濃度2018
- Author(s)
  藤谷顕雄、野田航介、村田美幸、神田敦宏、石田晋
- Organizer
  第72回日本臨床眼科学会
- Data Source
  KAKENHI-PROJECT-17K11442
[Presentation] Accumulation of acrolein-conjugated protein in the vitreous fluid of proliferative diabetic retinopathy2017
- Author(s)
  Noda K, Murata M, Saito W, Kanda A, Ishida S
- Organizer
  Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11442

1. 野田航介 (90296666)

# of Collaborated Projects: 4 results

# of Collaborated Products: 21 results
2. 加瀬諭 (60374394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Ishida Susumu (10245558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 神田敦宏 (80342707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 矢部一郎 (60372273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 菊地香澄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murata Miyuki 村田 美幸

村田 美幸 ムラタ ミユキ

伊藤 美幸

Research Projects

Research Products

Co-Researchers

滲出型加齢黄斑変性の網膜色素上皮障害における毒性アルデヒドアクロレインの関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of alphaB-crystallin in epithelial-mesenchymal transition in retinal Muller cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inflammation-inducing mechanism of acrolein in the pathogenesis of diabetic retinopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢黄斑変性におけるセリン/スレオニンキナーゼLRRK2の病態意義解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Mechanism of Retinal Neuropathology by Glycer-AGE and Drug Discovery for Diabetic Retinopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of acrolein generation in diabetic retinopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

網膜色素上皮細胞における上皮間葉移行関連転写因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Muller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Placental growth factor stabilizes VEGF receptor-2 protein in retinal pigment epithelial cells by downregulating glycogen synthase kinase 3 activity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ROCK1 Mediates Retinal Glial Cell Migration Promoted by Acrolein2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteolytic cleavage of vascular adhesion protein-1 induced by vascular endothelial growth factor in retinal capillary endothelial cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vascular Adhesion Protein-1 Blockade Suppresses Ocular Inflammation After Retinal Laser Photocoagulation in Mice2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy2017

Murata Miyuki 村田美幸

村田美幸ムラタミユキ

伊藤美幸