Kitano Hisataka 北野尚孝

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北野尚孝キタノヒサタカ

KITANO Hisataka 北野尚孝

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Researcher Number	50424726
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 日本大学, 医学部, 准教授 2022 – 2023: 日本大学, 医学部, 准教授 2017 – 2020: 日本大学, 医学部, 准教授 2014 – 2016: 日本大学, 医学部, 助教 2011 – 2013: 日本大学, 医学部, 専修指導医 2008 – 2010: Nihon University, 医学部, 専修医
Review Section/Research Field	Principal Investigator Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator 癌 / ゲノム / 遺伝子治療 / バイオテクノロジー / 蛋白質 / 遺伝子 / CXDXXXXYXCXC / 抗がん剤 / Del1タンパク / がん併用療法

Elucidation of treatment efficacy and application to new drug development of cancer gene therapy with Del1Principal Investigator
- Principal Investigator
  
  北野尚孝
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nihon University
Del1由来のE3C1ペプチドによるによるがん治療の確立Principal Investigator
- Principal Investigator
  
  北野尚孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nihon University
Effect of combination therapy of gene therapy with a Del1 and antibody-drugPrincipal Investigator
- Principal Investigator
  
  KITANO Hisataka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nihon University
Clarification of mechanism of gene therapy with a Del1Principal Investigator
- Principal Investigator
  
  KITANO Hisataka
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nihon University
The completion of protocol for gene therapy by Del1Principal Investigator
- Principal Investigator
  
  KITANO Hisataka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nihon University
The effect of Del-1 by in vivo gene therapyPrincipal Investigator
- Principal Investigator
  
  KITANO Hisataka
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nihon University
The effected of cancer gene therapy for Del 1 and Fas LPrincipal Investigator
- Principal Investigator
  
  KITANO Hisataka
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nihon University

All 2022 2021 2018 2017 2016 2015 2014 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] Targets in Gene Therapy (ISBN978-953-307-540-2)2011
- Author(s)
  Hisataka Kitano, Atsushi Mamiya, Chiaki Hidai
- Total Pages
  12
- Publisher
  InTech Inc
- Data Source
  KAKENHI-PROJECT-22792019
[Journal Article] Combination Cancer Therapy of a Del1 Fragment and Cisplatin Enhanced Therapeutic Efficiency In Vivo.2021
- Author(s)
  Hisataka Kitano, Yoh Masaoka, Atsushi Mamiya, Yusuke Fujiwara, Toshio Miki, Chiaki Hidai.
- Journal Title
  
  In Vivo
  
  Volume: 35 Issue: 2 Pages: 779-791
- DOI
  10.21873/invivo.12318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10850, KAKENHI-PROJECT-18K09800
[Journal Article] Nonviral Gene Therapy for Cancer: A Review2018
- Author(s)
  Chiaki Hidai, Hisataka Kitano
- Journal Title
  
  Diseases
  
  Volume: 6 Issue: 3 Pages: 1-12
- DOI
  10.3390/diseases6030057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09800
[Journal Article] Efficient cancer gene therapy with a Del1 fragment administered by hypodermic injection in a mouse explanted tumor model2018
- Author(s)
  Hisataka Kitano, Tomomi Ishikawa, Eri Tamura, Shinichiro Kokubun, Chiaki Hidai
- Journal Title
  
  Translational Cancer Researc
  
  Volume: 7 Issue: 3 Pages: 686-694
- DOI
  10.21037/tcr.2018.05.45
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09800
[Journal Article] EGF domain of coagulation factor IX is conducive to exposure of phosphatidylserine.2017
- Author(s)
  Chiaki Hidai, Yusuke Fujiwara, Shinichiro Kokubun, Hisataka Kitano.
- Journal Title
  
  Cell Biol Int.
  
  Volume: 41(4) Issue: 4 Pages: 374-383
- DOI
  10.1002/cbin.10733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11273
[Journal Article] Long-term gene therapy with Del1 fragment using nonviral vectors in mice with explanted tumors.2016
- Author(s)
  Hisataka Kitano, Atsushi Mamiya, Tomomi Ishikawa, Kayo Egoshi, Shinichiro Kokubun, Chiaki Hidai.
- Journal Title
  
  Onco Targets and Therapy.
  
  Volume: 9 Pages: 503-516
- DOI
  10.2147/ott.s90801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11273
[Journal Article] Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvβ8 with type Ⅰ collagen2014
- Author(s)
  Hayashido Y, Kitano H, Sakaue T, Fujii T, Suematsu M, Sakurai S, Okamoto T
- Journal Title
  
  Int J Oncol
  
  Volume: 45(5) Issue: 5 Pages: 1875-1882
- DOI
  10.3892/ijo.2014.2642
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390455, KAKENHI-PROJECT-24390456, KAKENHI-PROJECT-24593012, KAKENHI-PROJECT-26670865, KAKENHI-PROJECT-26893166
[Journal Article] A Del1 fragment improves the efficiency of FasL genetherapy with a non-viral vector in a mouse explantedtumor model2012
- Author(s)
  Hisataka Kitano, Atsushi Mamiya, Shinichiro Kokubun, Chiaki Hidai
- Journal Title
  
  Journal of Gene Medicine
  
  Volume: 14 Issue: 11 Pages: 642-650
- DOI
  10.1002/jgm.2682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24593012
[Journal Article] The Extracellular Matrix Protein Dell Induces Apoptosis viaits Epidermal Growth Factor Motif.2010
- Author(s)
  Hisataka Kitano, Shinichiro Kokubun, Chiaki Hidai.
- Journal Title
  
  Biochemical and Biophysical Research Communications 393(4)
  
  Pages: 757-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791551
[Journal Article] The Extracellular Matr ix Protein Del1 Induces Apoptosis via its Epidermal Growth Factor Motif2010
- Author(s)
  Hisataka Kitano, Shinichiro Kokubun, Chiaki Hidai
- Journal Title
  
  Biochemical and Biophysical Research C ommunications (BBRC). 393(4)
  
  Pages: 757-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791551
[Journal Article] The Extraceuar Matrix Protein Del1 Induces Apoptosis via its Epidermal Growth Factor Motif.2010
- Author(s)
  Hisataka Kitano, Shinichiro Kokubun, Chiaki Hidai.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 393(4) Pages: 757-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22792019
[Journal Article] The Del1 deposition domain can immobilize 3α-hydroxysteroid dehydrogenase in the extracellular matrix without interfering with enzymatic activity2009
- Author(s)
  Chiaki Hidai, Hisataka Kitano, Shinichiro Kokubun
- Journal Title
  
  Bioprocess Biosyst Eng. 32(5)
  
  Pages: 569-573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791551
[Journal Article] The Dell deposition domain can immobilize 3 a -hydroxysteroi d dehydrogenase in the extracellular matrix without interferi ng with enzymatic activity2008
- Author(s)
  Chiaki Hidai, Hisataka Kitano, Shinichiro Kokubun
- Journal Title
  
  Bioprocess Biosyst Eng (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791551
[Presentation] Del1とタキソイド系抗悪性腫瘍薬の併用による口腔扁平上皮癌細胞への影響2022
- Author(s)
  小宮山和寛、北野尚孝
- Organizer
  第67回（公社）日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K10159
[Presentation] An activation peptide of coagulation factor IX increases resistance to hypoxia in hypoxic model mice2017
- Author(s)
  Atsushi Mamiya, Hisataka Kitano, Chiaki Hidai
- Organizer
  12th International conference on cerebral vascular biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11273
[Presentation] A peptide from coagulation factor IX regulates endothelial barrier function and improves prognosis in traumatic brain injury model2017
- Author(s)
  Yuusuke Fuziwara, Hisataka Kitano,Chiaki Hidai
- Organizer
  12th International conference on cerebral vascular biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11273
[Presentation] An EGF motif of del1 suppresses notch function and inhibits efficient angiogenesis in vivo.2016
- Author(s)
  Hisataka Kitano
- Organizer
  5th International conference and Exhibition on Pathology
- Place of Presentation
  Chicago
- Year and Date
  2016-05-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11273
[Presentation] An EGF motif of Del1 suppresses Notch function and inhibits efficient angiogenesis in vivo2015
- Author(s)
  Hisataka Kitano
- Organizer
  American Society of Cell Biology
- Place of Presentation
  San Diego (USA)
- Year and Date
  2015-12-12
- Data Source
  KAKENHI-PROJECT-15K11273
[Presentation] Enrichment of transgene products with a deposition domain from Del1 protein2012
- Author(s)
  Hisataka Kitano
- Organizer
  SGCT 20th Anniversary Congress jointly organaised with the FSTCG
- Place of Presentation
  Versailles
- Data Source
  KAKENHI-PROJECT-24593012
[Presentation] Del1由来のペプチドによるがん遺伝子治療への応用2012
- Author(s)
  北野　尚孝
- Organizer
  日本口腔外科学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24593012
[Presentation] A peptide from Dell protein induced apoptosis in vitro2011
- Author(s)
  Hisataka Kitano, Atsushi Mamiya, Shinichiro Kokubun, Chiaki Hidai
- Organizer
  The American Society for Cell Biology
- Place of Presentation
  Denver
- Year and Date
  2011-12-05
- Data Source
  KAKENHI-PROJECT-22792019
[Presentation] Coagulation factor IX regulates cell migration via cell membrane
- Author(s)
  北野　尚孝
- Organizer
  日本口細胞生物学会
- Place of Presentation
  奈良県新公会堂（奈良県・奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24593012
[Presentation] Clustering of lipid rafts is accelerated by active coagulation factor IX via exposure to phosphatidylserine at the adhesion complex
- Author(s)
  Hisataka Kitano
- Organizer
  The American Society for Cell Biology
- Place of Presentation
  Philadelphia (USA)
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-24593012

1. 日台智明

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2. 林堂安貴

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3. 岡本哲治

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