YAMANOSHITA Osamu 山ノ下理

Researcher Number	50424924
External Links
Affiliation (based on the past Project Information) *help	2006 – 2018: 中部大学, 生命健康科学部, 講師 2015: 中部大学, 公私立大学の部局等, 講師 2013: 中部大学, 公私立大学の部局等, 講師
Review Section/Research Field	Principal Investigator Hygiene / Epidemiology and preventive medicine Except Principal Investigator Hygiene / Hygiene and public health / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator melanoma / selenium / 悪性黒色種 / セレニウム / メチル化 / 食品 / ガン / エピジェネティクス / 皮膚癌 / 皮膚がん / 悪性黒色腫 / 紫外線 / 皮膚ガン … More Except Principal Investigator … More 国際研究者交流 / トリクロロエチレン / 遺伝子改変マウス / 疫学 / 騒音 / 難聴 / 飲用井戸水 / 井戸水 / 皮膚癌 / RET / バングラデシュ / ヒ素 / HLA多型 / CYP2E1 / 免疫沈降 / 自己抗体 / ELISA / IgG / 疫学研究 / 皮膚病型 / 飲酒 / 喫煙 / 性差 / CYP2E1抗体 / Hypersensitivity / メラニン / 内耳性難聴 / ラセン神経節 / 先天性難聴 / 加齢性難聴 / 感音性難聴 / 騒音性難聴 / シグナル伝達 / 感音難聴 / 分子標的療法 / 色素細胞 / 労働衛生学 / 環境ストレス / SHRSP5/Dmcr / Wistar-Kyoto / 予防 / 炎症 / コラーゲン / 線維化 / 高脂肪-高コレステロール食 / ヒドララジン / 相互作用 / 胆汁酸 / 高脂肪食 / 血圧 / 非アルコール性脂肪性肝炎 / TNFα / SHR / CD68 / 線維症 / 降圧剤 / 高血圧 / コレステロール / NASH / 生物学的モニタリング / 尿中代謝物 / 遺伝子多型 / 皮膚障害 / ﾋﾄﾍﾟﾙﾍﾟｽｳｨﾙｽ6型 / ﾋﾄﾍﾙﾍﾟｽｳｨﾙｽ６型 / ﾄﾘｸﾛﾛｴﾁﾚﾝ / 過敏症症候群 / 有機溶剤 / ヒトヘルペスウイルス6型 / 過敏性症候群 / 重症薬疹 / 浄化剤 / 飲用水 / 発癌毒性 / 元素 / Placental Growth Factor / 発癌リスク / 騒音性難聴制御分子 / MP3プーヤー / 若年者 / 内耳機能 / 予防療法 / 聴覚障害 / 環境因子 / matrix metalloproteinase / アジア / 抗酸化剤 / ICP-MS / 重金属 / マレーシア / ベトナム / 癌遺伝子 / システイン / 癌遺伝子産物 / 発癌 / 再活性化 / ウラシル / シトシン / IE1遺伝子R3領域 / IEI遺伝子プロモーター / メチル化 / HHV6 Less

Anti-CYP2E1-induced by trichloroethylene exposure might be involved in the hypersensitivity syndrome
- Principal Investigator
  
  NASU Tamie
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  Chubu University
New prevention strategies for non-alcoholic steatohepatitis - a study on the importance of blood pressure and nutritional management
- Principal Investigator
  
  NASU Tamie
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  Chubu University
The search for effective food ingredient in cancer prevention to control epigeneticsPrincipal Investigator
- Principal Investigator
  
  YAMANOSHITA Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Chubu University
Review and analysis of mechanism for noise-induced deafness by epidemiological and experimental studies
- Principal Investigator
  
  Kato Masashi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Nagoya University
Cancer prevention based on the review for pollution of well drinking water in Asia
- Principal Investigator
  
  Kato Masashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagoya University
A study for developing a risk assessment battery for occupational trichloroethylene hypersensitivity syndrome
- Principal Investigator
  
  Kamijima Michihiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Nagoya City University
Analysis of the skin cancer induced by ultravioletPrincipal Investigator
- Principal Investigator
  
  YAMANOSHITA Osamu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Chubu University
Analysis of arsenic-mediated carcinogenesis and development of a preventive therapy targeting modulation for three-dimensional structure of oncogene products.
- Principal Investigator
  
  KATO Masashi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagoya University
  Chubu University
トリクロロエチレンによる全身性皮膚-肝障害はHHV6の脱メチル化が原因である
- Principal Investigator
  
  NASU Tamie
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Nagoya University
Development of preventive therapy of no-se-induced hearing loss through clarifying its mechanism
- Principal Investigator
  
  KATO MASASHI (KATO Masashi)
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  Chubu University
Chemopreventive effect of selenium against cancer and its mechanismPrincipal Investigator
- Principal Investigator
  
  YAMANOSHITA Osamu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Chubu University

All 2016 2015 2014 2013 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Chapter 3 Hypersensitivity Dermatitis and Hepatitis.In: Trichloroethylene：Toxicity and Health Risks.2014
- Author(s)
  Michihiro Kamijima,Hailan Wang, Osamu Yamanoshita, Yuki Ito, Tamie Nakajima.
- Publisher
  Humama Press
- Data Source
  KAKENHI-PROJECT-24406019
[Book] Hypersensitivity Dermatitis and Hepatitis2014
- Author(s)
  Kamijima M, Wang H, Yamanoshita O, Ito Y, Nakajima T
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-25460781
[Book] Trichloroethylene：Toxicity and Health Risks Molecular and Integrative Toxicology.2014
- Author(s)
  Kamijima M,Yamanoshita O,Nakajima T et al.
- Total Pages
  245
- Publisher
  Humama Press
- Data Source
  KAKENHI-PROJECT-24406019
[Journal Article] Carcinogenic risk of chromium, copper and arsenic in CCA-treated woods.2015
- Author(s)
  Ohgami N, Yamanoshita O, Thang ND, Yajima I, Nakano C, Wu W, Ohnuma S, Kato M.
- Journal Title
  
  Environ Pollut
  
  Volume: 206 Pages: 456-460
- DOI
  10.1016/j.envpol.2015.07.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460178, KAKENHI-PLANNED-24108002, KAKENHI-PROJECT-15H02588, KAKENHI-PROJECT-25340052, KAKENHI-PROJECT-25460781, KAKENHI-PROJECT-24390157
[Journal Article] GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity.2014
- Author(s)
  Yajima I, Kumasaka MY, Yamanoshita O, Zou C, Li X, Ohgami N, Kato M
- Journal Title
  
  Am J Cancer Res
  
  Volume: 4 Pages: 182-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460781
[Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.2013
- Author(s)
  Kumasaka YM, et al.
- Journal Title
  
  Arch Toxicol.
  
  Volume: 87 Issue: 3 Pages: 439-447
- DOI
  10.1007/s00204-012-0964-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406003, KAKENHI-PROJECT-22590558, KAKENHI-PROJECT-22791092, KAKENHI-PROJECT-23390183, KAKENHI-PROJECT-24406002, KAKENHI-PROJECT-24591670
[Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.2013
- Author(s)
  Kumasaka YM, Yamanoshita O, Shimizu S, Ohnuma S, Furuta A, Yajima I, Nizam S, Khalequzzaman M, Shekhar UH, Nakajima T, Kato M
- Journal Title
  
  Arch Toxicol
  
  Volume: 87 Pages: 439-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406003
[Journal Article] Occupational trichloroethylene hypersensitivity syndrome: Human herpesvirus 6 reactivation and rash phenotypes.2013
- Author(s)
  Michihiro Kamijima, M.D., Ph.D.; Hailan Wang; Osamu Yamanoshita; Yuki Ito; Lihua Xia; Yukie Yanagiba; Cishan Chen; Ai Okamura; Zhenlie Huang; Xinxiang Qiu; Xiangrong Song; Tingfeng Cai; Lili Liu; Yichen Ge; Yingyu Deng; Hisao Naito; Tetsushi Yoshikawa; Mikiko Tohyama; Laiyu Li; Hanlin Huang; Tamie Nakajima
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 72 Pages: 218-224
- Data Source
  KAKENHI-PROJECT-25460781
[Journal Article] Occupational trichloroethylene hypersensitivity syndrome: Human herpesvirus 6 reactivation and rash phenotypes2013
- Author(s)
  Kamijima M, Wang H, Yamanoshita O, Ito Y, Xia L, Yanagiba Y, Chen C, Okamura A, Huang Z, Qiu X, Song X, Cai T, Liu L, Ge Y, Deng Y, Naito H, Yoshikawa T, Tohyama M, Li L, Huang H, Nakajima T
- Journal Title
  
  J. Occup Health
  
  Volume: 72 Issue: 3 Pages: 443-449
- DOI
  10.1016/j.jdermsci.2013.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390183, KAKENHI-PROJECT-24406019, KAKENHI-PROJECT-24659299
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
- Author(s)
  Kato M, Takeda K, Hossain K, Thang D.N., Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
- Journal Title
  
  J Cell Biochem 110
  
  Pages: 399-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406003
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
- Author(s)
  Kato M, Takeda K, Hossain K, Thang D. Nguyen, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
- Journal Title
  
  J Cell Biochem
  
  Volume: 110 Pages: 399-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20406003
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
- Author(s)
  Kato M, Takeda K, Hossain K, Thang D.Nguyen, Kaneko Y, Kumasaka M,Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y
- Journal Title
  
  J Cell Biochem 110
  
  Pages: 399-407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390168
[Journal Article] Selenium-enriched Japanese radish sprouts influence glutathione peroxidase and glutathione S-transferase in an organ-specific manner in rats.2008
- Author(s)
  Hama H, Yamanoshita O, Chiba M, Takeda I, Nakajima T.
- Journal Title
  
  J Occup Health. 50(2)
  
  Pages: 147-54
- NAID
  110006680532
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590578
[Journal Article] Chemopreventive effect of selenium-enriched Japanese radish sprout against breast cancer induced by 7, 12-dimethylbenz[a]anthracene in rats.2007
- Author(s)
  Yamanoshita O, Ichihara S, Hama H, Ichihara Q Chiba M, Kamijima M, Takeda I, Nakajima T.
- Journal Title
  
  Tohoku J Exp Med. 212(2)
  
  Pages: 191-8
- NAID
  10019574670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590578
[Journal Article] Chemopreventive effect of selenium-enriched Japanese radish sprout against breast cancer induced by 7,12-dimethylbenzanthracenc in rats。2007
- Author(s)
  Yamanoshita, et. al.
- Journal Title
  
  Tohoku J Exp Med. 212
  
  Pages: 191-198
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590578
[Journal Article] Chemopreventive effect of selenium-enriched Japanese radish sprout against breast cancer induced by 7, 12-dimethylbenz[a]anthracene in rats.2007
- Author(s)
  Yamanoshita, et. al.
- Journal Title
  
  Tohoku J Exp Med. 212
  
  Pages: 191-198
- NAID
  10019574670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590578
[Presentation] トリクロロエチレンによるHypersensitivity-患者の曝露濃度から許容濃度再考の必要性を考察する-2016
- Author(s)
  那須民江、王棟、王海蘭、山ノ下理、伊藤由起、内藤久雄、上島通浩
- Organizer
  第89回日本産業衛生学会
- Place of Presentation
  福島県文化センター（福島市）
- Year and Date
  2016-05-24
- Data Source
  KAKENHI-PROJECT-24406019
[Presentation] トリクロロエチレン曝露量とHLA遺伝型に対する皮膚過敏症への影響2015
- Author(s)
  山ノ下理、上島通浩、王海蘭、伊藤由紀、内藤久雄、那須民江
- Organizer
  平成27年度日本産業衛生学会東海地方会学会
- Place of Presentation
  名古屋大学（名古屋市）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-24406019
[Presentation] トリクロロエチレンによるHypersensitivity－15年間の日中共同研究による患者の曝露濃度推移の考察－2015
- Author(s)
  那須民江、王棟、王海蘭、山ノ下理、伊藤由紀、内藤久雄、上島通浩
- Organizer
  平成27年度日本産業衛生学会東海地方会学会
- Place of Presentation
  名古屋大学（名古屋市）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-24406019
[Presentation] トリクロロエチレンによる重症皮膚肝障害の個体感受性マーカーの解析2015
- Author(s)
  山ノ下　理、内藤　久雄、伊藤　由起、王　海蘭、黄　漢林、上島　通浩、那須　民江
- Organizer
  日本産業衛生学会東海地方会
- Place of Presentation
  名古屋大学医学部（愛知県名古屋市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25460781
[Presentation] トリクロロエチレンによる重症皮膚肝障害の個体感受性マーカーと尿中代謝物との関連性の解析2014
- Author(s)
  山ノ下理、王海蘭、内藤久雄、伊藤由起、王棟、上島通浩、黄漢林、那須民江.
- Organizer
  第87回日本産業衛生学会
- Place of Presentation
  岡山コンベンションセンター（岡山）
- Data Source
  KAKENHI-PROJECT-24406019
[Presentation] Human herpesvirus 6 reactivation in trichloroethylene-induced hypersensitivity dermatitis2013
- Author(s)
  Kamijima M, Yamanoshita O,Ito Y,Nakajima T
- Organizer
  8th International Conference on HHV-6&7
- Place of Presentation
  UIC Espaces Congrès（Paris　France)
- Data Source
  KAKENHI-PROJECT-24406019
[Presentation] 悪性黒色腫におけるNKX3.1遺伝子変異の解析2013
- Author(s)
  山ノ下理
- Organizer
  第83回日本衛生学会学術総会
- Place of Presentation
  金沢市
- Year and Date
  2013-03-25
- Data Source
  KAKENHI-PROJECT-22590558
[Presentation] Human herpesvirus 6 reactivation in trichloroethylene-induced hypersen sitivity dermatitis.2013
- Author(s)
  Kamijima M Yamanoshita O, Ito Y, Nakajima T, et al.
- Organizer
  8th International Conference on HHV-6&7
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-24406019
[Presentation] 重金属吸着剤におけるヒ素除去能力の検討2010
- Author(s)
  山ノ下理・大神信孝・大沼章子・林留美子・加藤昌志
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  宮城県(仙台国際センター)
- Data Source
  KAKENHI-PROJECT-20406003
[Presentation] ヒ素によるガン化とその除去に関する解析2009
- Author(s)
  山ノ下理・上村規行・加藤昌志
- Place of Presentation
  東京都(北里大学)
- Data Source
  KAKENHI-PROJECT-20406003
[Presentation] Chemopreventive effects of selenium in a transgenic mouse model of melanoma2008
- Author(s)
  Osamu Yamanoshita, Yuki Ito, Ai Okamura, Masashi Kato, Tamie Nasu
- Organizer
  The Japanese society for Hygiene
- Place of Presentation
  Kumamoto
- Year and Date
  2008-03-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590578
[Presentation] メラノーマ自然発症モデルマウスにおけるセレニウムの予防効果2008
- Author(s)
  山ノ下理
- Organizer
  第78回日本衛生学会
- Place of Presentation
  熊本県熊本市桜町1-3熊本市民会館
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-18590578
[Presentation] メラノーマ自然発症モデルマウスにおけるセレニウムの予防効果2008
- Author(s)
  山ノ下理
- Organizer
  第78回日本衛生学会
- Place of Presentation
  熊本県熊本市桜町1・3熊本市民会館
- Year and Date
  2008-03-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590578
[Presentation] The 20^<th> IPCC (International Pigment Cell Conference)/5^<th> IMRC (International Melanoma Research Congress)2008
- Author(s)
  Masashi Kato, Nobutaka Ohgami, Ichiro Yajima, Mayuko Kumasaka, Osamu Yamanoshita
- Organizer
  Poster session Effect of hyperpigmented skinon ultraviolet-mediated cancer
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-19390168
[Presentation] 悪性黒色腫におけるNKX3.1遺伝子変異の解析
- Author(s)
  山ノ下　理
- Organizer
  第83回日本衛生学会学術総会
- Place of Presentation
  金沢大学（石川県）
- Data Source
  KAKENHI-PROJECT-22590558
[Presentation] トリクロロエチレンによる重症皮膚肝障害の個体感受性マーカーと尿中代謝物との関連性の解析.
- Author(s)
  山ノ下理、王海蘭、内藤久雄、伊藤由起、王棟、上島通浩、黄漢林、那須民江.
- Organizer
  第87回日本産業衛生学会
- Place of Presentation
  岡山ｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ（岡山県・岡山市）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24406019

1. NASU Tamie (10020794)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
2. KATO Masashi (10281073)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
3. OHGAMI Nobutaka (80424919)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. Kamijima Michihiro (80281070)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
5. KAWAMOTO Yoshiyuki (10410664)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. GOTO Yuji (70362522)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NAITO Hisao (90547556)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
8. YAJIMA Ichiro (80469022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. ITO Yuki (80452192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
10. Wang Hailan

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
11. TAKEDA Kozue (80345884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 伊田みちる (80393148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石井晃 (30252175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 浅井直也 (80273233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Huang Hanlin

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. YUAN yuan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMANOSHITA Osamu 山ノ下 理

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Analysis of the skin cancer induced by ultravioletPrincipal Investigator

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Chemopreventive effect of selenium against cancer and its mechanismPrincipal Investigator

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[Book] Chapter 3 Hypersensitivity Dermatitis and Hepatitis.In: Trichloroethylene：Toxicity and Health Risks.2014

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[Book] Hypersensitivity Dermatitis and Hepatitis2014

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[Book] Trichloroethylene：Toxicity and Health Risks Molecular and Integrative Toxicology.2014

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[Journal Article] Carcinogenic risk of chromium, copper and arsenic in CCA-treated woods.2015

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YAMANOSHITA Osamu 山ノ下理