ISEKI Hiroyoshi 伊関大敬

Researcher Number	50433652
Other IDs	https://orcid.org/0000-0001-5997-5564
Affiliation (based on the past Project Information) *help	2015 – 2019: 筑波大学, 国際統合睡眠医科学研究機構, 助教 2007 – 2008: Saitama Medical University, 医学部, 研究員
Review Section/Research Field	Principal Investigator Laboratory animal science / Tumor biology / Digestive surgery
Keywords	Principal Investigator モデル動物 / CRISPR / エピゲノム / エピゲノム変異モデルマウス / がん / lncRNA / CRISPR/Cas9 / エピゲノム編集 / マイクロアレイ / DNAメチル化 / c-Myc / 大腸癌 / 小腸大腸肛門外科学

Development of an integrated epigenome regulation system and animal model for epigenomic diseasePrincipal Investigator
- Principal Investigator
  
  Iseki Hiroyoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
Development of an epigenome-editing technology for inducing cancer epimutations in micePrincipal Investigator
- Principal Investigator
  
  ISEKI Hiroyoshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  University of Tsukuba
Analysis of the relevance of c-Myc function to de novo methylation in colorectal cancerPrincipal Investigator
- Principal Investigator
  
  ISEKI Hiroyoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Saitama Medical University

All 2019 2018 2016 2008

All Journal Article Presentation

[Journal Article] Cables2 Is a Novel Smad2-Regulatory Factor Essential for Early Embryonic Development in Mice2019
- Author(s)
  Dinh TTH, Iseki H, Mizuno S, Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami KI, Wilson V, Arkell R, Sugiyama F.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/744128
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07130
[Journal Article] Germline recombination in a novel Cre transgenic line, Prl3b1-cre mouse.2016
- Author(s)
  Al-Soudy AS, Hiromori Y, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki Hi, Yoshiki A, Nagase H, Nakanishi T, Takahashi S, Oishi H, Sugiyama F.
- Journal Title
  
  Genesis.
  
  Volume: 54(7) Issue: 7 Pages: 389-97
- DOI
  10.1002/dvg.22944
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221004, KAKENHI-PROJECT-25281026, KAKENHI-PROJECT-25293031, KAKENHI-PROJECT-26290028, KAKENHI-PROJECT-15K14989, KAKENHI-PROJECT-15K20888, KAKENHI-PROJECT-15K00560, KAKENHI-PROJECT-16K15150
[Journal Article] Combined overexpression of JARID2, PRDM14, ESRRB, and SALL4A dramatically improves efficiency and kinetics of reprogramming to induced pluripotent stem cells.2016
- Author(s)
  Iseki H, Nakachi Y, Hishida T, Yamashita-Sugahara Y, Hirasaki M, Ueda A, Tanimoto Y, Iijima S, Sugiyama F, Yagami K, Takahashi S, Okuda A, Okazaki Y
- Journal Title
  
  Stem Cells
  
  Volume: 34 Issue: 2 Pages: 322-333
- DOI
  10.1002/stem.2243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20888, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112512, KAKENHI-PROJECT-25293082
[Journal Article] Generation of CRISPR/Cas9-mediated bicistronic knock-in <i>ins1-cre</i> driver mice2016
- Author(s)
  Yoshikazu Hasegawa, Yoshikazu Hoshino, Abdelaziz E. Ibrahim, Kanako Kato, Yoko Daitoku1, Yoko Tanimoto, Yoshihisa Ikeda, Hisashi Oishi, Satoru Takahashi, Atsushi Yoshiki, Ken-ichi Yagami, Hiroyoshi Iseki, Seiya Mizuno, Fumihiro Sugiyama
- Journal Title
  
  Exp. Anim.
  
  Volume: 65 Issue: 3 Pages: 319-327
- DOI
  10.1538/expanim.16-0016
- NAID
  130006882371
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14359, KAKENHI-PROJECT-26221004, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-26290028, KAKENHI-PROJECT-26460356, KAKENHI-PROJECT-15K20888, KAKENHI-PROJECT-26870077, KAKENHI-PROJECT-16K14588
[Presentation] Cables2 regulates mouse gastrulation by stimulating Wnt/β-catenin signalling pathway.2019
- Author(s)
  Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Takahashi S, Yagami K, Sugiyama F.
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-17K07130
[Presentation] Essential role of Cables2 gene for gastrulation of the mouse embryo2018
- Author(s)
  Tra Thi Huong Dinh, Hiroyoshi Iseki, Seiya Mizuno, Saori Mizuno, Yoko Tanimoto, Yoko Daitoku, Kanako Kato, Noriko Kajiwara, Masatsugu Ema, Jun-Dal Kim, Junji Ishida, Akiyoshi Fukamizu, Mitsuyasu Kato, Satoru Takahashi, Ken-ichi Yagami, Fumihiro Sugiyama
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-17K07130
[Presentation] Jarid2過剰発現による効率的なiPS細胞誘導2016
- Author(s)
  伊関　大敬、仲地　豊、菱田　友昭、菅原　泉、谷本　陽子、飯島　沙織、杉山　文博、八神　健一、高橋　智、奥田　晶彦、岡崎　康司
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都府京都市南区東九条下殿田町70番地　京都テルサ
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K20888
[Presentation] Identification of a causative gene involved in resistance of lymphoma cells to rat parvovirus oncolytic infection by a genome-wide DNA methylation analysis2016
- Author(s)
  伊関　大敬、今野　裕士、奥泉　久人、高橋　智、八神　健一、杉山　文博
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市西区みなとみらい一丁目1番1号　パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K20888
[Presentation] Promoter methylation inhibits Wnt/β-catenin-mediated transcriptional activation of ALEXI in human colorectal cancer2008
- Author(s)
  伊関大敬
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19790953
[Presentation] Promoter methylation inhibits Wnt/・-catenin-mediated transcriptional activation of ALEX1 in human colorectal cancer2008
- Author(s)
  伊関大敬
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19790953

1. 杉山文博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 水野聖哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 高橋智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISEKI Hiroyoshi 伊関 大敬

Research Projects

Research Products

Co-Researchers

Development of an integrated epigenome regulation system and animal model for epigenomic diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of an epigenome-editing technology for inducing cancer epimutations in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the relevance of c-Myc function to de novo methylation in colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cables2 Is a Novel Smad2-Regulatory Factor Essential for Early Embryonic Development in Mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Germline recombination in a novel Cre transgenic line, Prl3b1-cre mouse.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined overexpression of JARID2, PRDM14, ESRRB, and SALL4A dramatically improves efficiency and kinetics of reprogramming to induced pluripotent stem cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of CRISPR/Cas9-mediated bicistronic knock-in <i>ins1-cre</i> driver mice2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] Cables2 regulates mouse gastrulation by stimulating Wnt/β-catenin signalling pathway.2019

Author(s)

Organizer

Data Source

[Presentation] Essential role of Cables2 gene for gastrulation of the mouse embryo2018

Author(s)

Organizer

Data Source

[Presentation] Jarid2過剰発現による効率的なiPS細胞誘導2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Identification of a causative gene involved in resistance of lymphoma cells to rat parvovirus oncolytic infection by a genome-wide DNA methylation analysis2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Promoter methylation inhibits Wnt/β-catenin-mediated transcriptional activation of ALEXI in human colorectal cancer2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Promoter methylation inhibits Wnt/・-catenin-mediated transcriptional activation of ALEX1 in human colorectal cancer2008

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

ISEKI Hiroyoshi 伊関大敬