Kidokoro Kengo 城所研吾

Researcher Number	50435020
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2017 – 2025: 川崎医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine Except Principal Investigator Basic Section 53040:Nephrology-related / Basic Section 56030:Urology-related / Kidney internal medicine
Keywords	Principal Investigator P2受容体 / 内皮機能障害 / ATP / 内皮-上皮連関 / 糖尿病性腎臓病 / Calcium dynamics / Oxidative stress / GFR / Keap1/Nrf2 / Keap1-Nrf2 … More / 細胞内カルシウム / TRPC / GFR制御 / Keap1-Nrf2機構 / 糸球体内皮上皮連関 / カルシウム動態 / 細胞内カルシウム濃度 / Pannexin1 / ポドサイト障害 / ATP感受性イオンチャネル型受容体 / 内皮上皮連関 / 糖尿病性腎障害 / 内皮アポトーシス / 血漿中ATPレベル / 糸球体上皮障害 / 糸球体内皮-上皮連関 / in vivo imaging / 内皮細胞障害 … More Except Principal Investigator 慢性腎臓病 / 線維化 / 腎移植 / 内皮機能障害 / 内皮障害 / 酸化ストレス / TRPC / NO / 糸球体上皮細胞 / sGC / 虚血再灌流障害 / 急性腎障害 / 腎虚血再還流障害 / 老化 / ポドサイト / 炎症 / 加齢 / Wnt / インフラマソーム / 慢性炎症 / カルシウム / マクロファージ / 細胞老化 / ストレスDNA損傷 / PKG / 活性酸素種 / 虚血再灌流 / スタチン / MMP / 好中球 / 内皮細胞 / 繊維化 / 血行動態変化 / 糖尿病性腎臓病 / 腎虚血再灌流障害 / 内皮/上皮連関 / Keap-1/Nrf2 / Keap1/Nrf-2 / NLRP3 inflammasome / Wnt/βーcatenine / 多光子レーザー顕微鏡 / in vivo imaging / アルブミン尿 / 一酸化窒素 / 認知機能障害 / 酸化ストレアス / Nrf2 / 血管内皮障害 Less

糖尿病性腎症におけるミネラルコルチコイド受容体活性による腎微小循環動態制御の解明Principal Investigator
- Principal Investigator
  
  城所研吾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Unraveling the pathophysiology of kidney disease and developing treatments based on the endothelial/epithelial pathomechanical linkage and ROS/NO imbalance.
- Principal Investigator
  
  柏原直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Elucidating the Relationship between Stress DNA Damage and Exacerbation of Kidney Disease
- Principal Investigator
  
  岸誠司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
血管内皮細胞による免疫調整機構と腎疾患進展における役割の解明
- Principal Investigator
  
  佐々木環
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
老化関連腎障害におけるTRPC依存的Ca動態による糸球体内微小炎症の制御機構解明
- Principal Investigator
  
  長洲一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Elucidation of the role of the Keap1-Nrf2 mechanism in the regulation of glomerular filtration rate (GFR)Principal Investigator
- Principal Investigator
  
  城所研吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Novel therapies for renal ischemia-reperfusion injury
- Principal Investigator
  
  荒木元朗
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Development of a comprehensive spatio-temporal understanding of the pathogenesis and progression of chronic kidney disease and the development of therapeutic strategies
- Principal Investigator
  
  Kashihara Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
MMP inhibition of statins proves renal protection via neutrophil infiltration
- Principal Investigator
  
  Yoshinaga Kasumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
sGC activation on the interaction between glomerular endothelial cells and podcyte.
- Principal Investigator
  
  Nagasu Hajime
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Is the PDE5 inhibitor tadalafil an innovative treatment for renal ischemia reperfusion injury?
- Principal Investigator
  
  Motoo Araki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Okayama University
Evaluation of the role of endothelial pannexin1 in progression of diabetic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Kidokoro Kengo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Implications of endothelial injuries and endothelial/epithelial interactions as pathogenetic mechanisms underlying progression of chronic kidney disease and its therapeutic application.
- Principal Investigator
  
  Kashihara Naoki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kawasaki Medical School
Elucidation of mechanism of the progression of glomerular injury via ATP/P2Y2 receptor pathway in diabetic kidney disease.Principal Investigator
- Principal Investigator
  
  Kidokoro Kengo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kawasaki Medical School
Investigation of molecular mechanisms of endothelial dysfunction underlying CKD and aging kidney
- Principal Investigator
  
  Kashihara Naoki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kawasaki Medical School

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Oxidative stress and the role of redox signalling in chronic kidney disease.2024
- Author(s)
  Kishi S, Nagasu H, Kidokoro K, Kashihara N.
- Journal Title
  
  Nat Rev Nephrol.
  
  Volume: 20 Issue: 2 Pages: 101-119
- DOI
  10.1038/s41581-023-00775-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02937
[Journal Article] 腎臓病研究におけるイメージング技術の進歩を展望.2023
- Author(s)
  城所研吾,柏原直樹.
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 65 Pages: 942-950
- Data Source
  KAKENHI-PROJECT-21H02937
[Journal Article] Activation of the inflammasome drives peritoneal deterioration in a mouse model of peritoneal fibrosis2023
- Author(s)
  Kadoya Hiroyuki、Hirano Akira、Umeno Reina、Kajimoto Eriko、Iwakura Tsukasa、Kondo Megumi、Wada Yoshihisa、Kidokoro Kengo、Kishi Seiji、Nagasu Hajime、Sasaki Tamaki、Taniguchi Shun’ichiro、Takahashi Masafumi、Kashihara Naoki
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 9
- DOI
  10.1096/fj.202201777rrr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06613, KAKENHI-PROJECT-21K08114, KAKENHI-PROJECT-21K16199, KAKENHI-PROJECT-21H02937
[Journal Article] Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway.2023
- Author(s)
  Kidokoro K, Kadoya H, Cherney DZI, Kondo M, Wada Y, Umeno R, Kishi S, Nagasu H, Nagai K, Suzuki T, Sasaki T, Yamamoto M, Kanwar YS, Kashihara N.
- Journal Title
  
  Kidney360.
  
  Volume: 4 Issue: 10 Pages: 1454-1466
- DOI
  10.34067/kid.0000000000000171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02937
[Journal Article] Kidney vascular congestion exacerbates acute kidney injury in mice2022
- Author(s)
  Kitani T、Kidokoro K、Nakata T、Kirita Y、Nakamura I、Nakai K、Yagi-Tomita A、Ida T、Uehara-Watanabe N、Ikeda K、Yamashita N、Humphreys BD、Kashihara N、Matoba S、Tamagaki K、Kusaba T
- Journal Title
  
  Kidney International
  
  Volume: 101 Issue: 3 Pages: 551-562
- DOI
  10.1016/j.kint.2021.11.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937, KAKENHI-PROJECT-20K08640
[Journal Article] Evaluation of Neutrophil Dynamics Change by Protective Effect of Tadalafil After Renal Ischemia/Reperfusion Using In Vivo Real-time Imaging2022
- Author(s)
  Maruyama Y、Araki M、Kidokoro K、Sogawa Y、Yoshinaga K、Mitsui Y、Sadahira T、Wada K、Watanabe M、Watanabe T、Kashihara N、Nasu Y
- Journal Title
  
  Transplantation
  
  Volume: 106 Issue: 2 Pages: 280-288
- DOI
  10.1097/tp.0000000000003803
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02937, KAKENHI-PROJECT-19K09711
[Journal Article] Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation2021
- Author(s)
  Wada Y、Umeno R、Nagasu H、Kondo M、Tokuyama A、Kadoya H、Kidokoro K、Taniguchi S、Takahashi M、Sasaki T、Kashihara N
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 17 Pages: 9269-9269
- DOI
  10.3390/ijms22179269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02937, KAKENHI-PROJECT-20K08602, KAKENHI-PROJECT-21K06613
[Journal Article] Dipeptidyl peptidase-4 inhibitor linagliptin reduces urinary albumin excretion through the protection of glomerular endothelial function2021
- Author(s)
  Kondo M, Kidokoro K, Uchida A, Kadoya H, Umeno R, Tokuyama A, Wada Y, Nagasu H, Kanda E, Sasaki T, Kashihara N
- Journal Title
  
  Kawasaki Medical Journal
  
  Volume: 47 Pages: 131-141
- DOI
  10.11482/KMJ-E202147131
- ISSN
  0385-0234, 2434-3404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02937
[Journal Article] Essential role and therapeutic targeting of the glomerular endothelial glycocalyx in lupus nephritis2020
- Author(s)
  Kadoya Hiroyuki、Yu Ning、Schiessl Ina Maria、Riquier-Brison Anne、Gyarmati Georgina、Desposito Dorinne、Kidokoro Kengo、Butler Matthew J.、Jacob Chaim O.、Peti-Peterdi Janos
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 19
- DOI
  10.1172/jci.insight.131252
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Journal Article] Renoprotective effects of sodium-glucose cotransporter-2 inhibitors and underlying mechanisms.2020
- Author(s)
  Kashihara N, Kidokoro K, Kanda E.
- Journal Title
  
  Curr Opin Nephrol Hypertens
  
  Volume: 29 Issue: 1 Pages: 112-118
- DOI
  10.1097/mnh.0000000000000561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02828
[Journal Article] Klotho is a novel therapeutic target in peritoneal fibrosis via Wnt signaling inhibition.2020
- Author(s)
  Kadoya H, Satoh M, Nishi Y, Kondo M, Wada Y, Sogawa Y, Kidokoro K, Nagasu H, Sasaki T, Kashihara N.
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: - Issue: 5 Pages: 773-781
- DOI
  10.1093/ndt/gfz298
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02828
[Journal Article] Evaluation of Glomerular Hemodynamic Function by Empagliflozin in Diabetic Mice using In Vivo Imaging.2019
- Author(s)
  1.Kidokoro K, Cherney DZI, Bozovic A, Nagasu H, Satoh M, Kanda E, Sasaki T, Kashihara N
- Journal Title
  
  Circulation
  
  Volume: in press Issue: 4 Pages: 303-315
- DOI
  10.1161/circulationaha.118.037418
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Journal Article] Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function2019
- Author(s)
  Nagasu Hajime、Sogawa Yuji、Kidokoro Kengo、Itano Seiji、Yamamoto Toshiya、Satoh Minoru、Sasaki Tamaki、Suzuki Takafumi、Yamamoto Masayuki、Wigley W. Christian、Proksch Joel W.、Meyer Colin J.、Kashihara Naoki
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 11 Pages: 12253-12263
- DOI
  10.1096/fj.201900217r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02828, KAKENHI-PROJECT-18K19417
[Journal Article] The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice2018
- Author(s)
  Yuji Sogawa, Hajime Nagasu , Seiji Itano, Kengo Kidokoro, Shun’ichiro Taniguchi, Masafumi Takahashi, Hiroyuki Kadoya, Minoru Satoh, Tamaki Sasaki, Naoki Kashihara
- Journal Title
  
  ProS One
  
  Volume: 13 Issue: 10 Pages: e0203823-e0203823
- DOI
  10.1371/journal.pone.0203823
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06781, KAKENHI-PROJECT-18H02828
[Journal Article] 5-aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury.2018
- Author(s)
  Uchida A, Kidokoro K, Sogawa Y, Itano S, Nagasu H, Satoh M, Sasaki T, Kashihara N
- Journal Title
  
  Nephrology (Carlton)
  
  Volume: - Issue: 1 Pages: 28-38
- DOI
  10.1111/nep.13189
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04838
[Journal Article] Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice.2017
- Author(s)
  Sogawa Y, Nagasu H, Iwae S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T and Kashihara N.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 8801-8801
- DOI
  10.1038/s41598-017-08054-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15590, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04838, KAKENHI-PROJECT-15K09146, KAKENHI-PROJECT-16K19501
[Journal Article] 慢性腎臓病（CKD)と急性腎障害（AKI)　循環器薬物療法を行う際の投薬計画2016
- Author(s)
  長洲一、城所研吾、柏原直樹
- Journal Title
  
  医学のあゆみ
  
  Volume: 259 Pages: 1353-1358
- Data Source
  KAKENHI-PROJECT-15H04838
[Journal Article] Feasibility of fluorescence energy transfer system for imaging the renoprotective effects of aliskiren in diabetic mice.2016
- Author(s)
  Kidokoro K, Satoh M, Itano S, Kuwabara A, Sasaki T, Kashihara N.
- Journal Title
  
  J Renin Angiotensin Aldosterone Syst.
  
  Volume: 17 Issue: 2
- DOI
  10.1177/1470320315625704
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04838
[Journal Article] 腎代替療法とフリーラジカル　慢性腎臓病（CKD)2016
- Author(s)
  柏原直樹、長洲一、城所研吾、佐藤稔
- Journal Title
  
  腎と透析
  
  Volume: 81 Pages: 1007-1013
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Podocyte のカルシウム(Ca2+)動態に着目した非ステロイド性ミネラルコルチコイド受容体(MR)拮抗薬によるアルブミン尿改善効果の分子メカニズムの解明.2023
- Author(s)
  岩倉主、城所研吾、立川理絵、岸誠司、長洲一、柏原直樹、佐々木環.
- Organizer
  第45回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 腎不全モデルマウスにおけるプロスタサイクリン誘導体の腸管微小血流及びバリア機能に対する作用の検討.2023
- Author(s)
  平野憲、角谷裕之、松浦巧、車谷元、城所研吾、柏原直樹.
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 内皮機能障害はβカテニンの活性化によるM1/ M2マクロファージ分化誘導を介して、AKI to CKD transition を促進する.2023
- Author(s)
  高須将伸、岸誠司、長洲一、立川理絵、梶本恵莉子、平野憲、岩倉主、梅野怜奈、角谷裕之、城所研吾、佐々木環、柏原直樹.
- Organizer
  第13回腎不全研究会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 糖尿病性腎臓病における内皮/上皮病態連関、NO/sGC 活性化不全の解明.2023
- Author(s)
  梶本恵莉子、高須将伸、立川理絵、岩倉主、梅野怜奈、城所研吾、岸誠司、長洲一、佐々木環、柏原直樹.
- Organizer
  第34回日本糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 糖尿病性腎臓病における非ステロイド系ミネラルコルチコイド受容体拮抗薬による腎保護機序の解明.2023
- Author(s)
  岩倉主、城所研吾、立川理絵、高須将伸、梶本恵莉子、平野憲、梅野怜奈、岸誠司、長洲一、佐々木環、柏原直樹.
- Organizer
  第34回日本糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] Elucidation of the Molecular Mechanism of Albuminuria Improvement by Nonsteroidal Mineralocorticoid Receptor(MR) Antagonists Focusing on Podocyte Calcium (Ca2+)Dynamics.2023
- Author(s)
  Tsukasa Iwakura, Kengo Kidokoro, Seiji Kishi, Hajime Nagasu, Naoki Kashihara, Tamaki Sasaki.
- Organizer
  American Society of Nephrology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] Glomerular Hemodynamic Changes with SGLT2 Inhibition in Type 2 Diabetic Rats Using In Vivo Imaging2022
- Author(s)
  Rie Tatsugawa, Yoshihisa Wada, Kengo Kidokoro, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 進行性腎障害における糸球体高血圧に対するアプローチ2022
- Author(s)
  城所　研吾、柏原　直樹
- Organizer
  第65回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 糖尿病性腎臓病の進展にはインフラマソームの活性化が関与する2022
- Author(s)
  梅野怜奈、長洲一、角谷裕之、城所研吾、岸　誠司、柏原直樹
- Organizer
  第３３回日本糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] Regulatory mechanism of glomerular filtration rate by the Keap1/Nrf2 pathway2022
- Author(s)
  Kengo Kidokoro, Hiroyuki Kadoya, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] eNOS-NO pathway modulates AKI to CKD transition in IRI model mice via regulation of βCatenin translocation2022
- Author(s)
  Masanobu Takasu, Megumi Kondo, Hajime Nagasu, Hiroyuki Kadoya, Seiji Kishi, Kengo Kidokoro, Naoki Kashihara
- Organizer
  the29th ISH (The 29th Scientific Meeting of the International Society of Hypertension)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] リアルタイムイメージングを用いた腎虚血再灌流後生体マウス腎における好中球動態のタダラフィル投与による変化2021
- Author(s)
  丸山雄樹, 荒木元朗, 城所研吾
- Organizer
  第109回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09711
[Presentation] マクロファージにおけるNrf2活性化はインフラマソーム活性化制御により糖尿病性腎臓病の進展を抑制する2021
- Author(s)
  近藤恵、長洲一、梅野怜奈、城所研吾、柏原直樹
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] 2型糖尿病モデル動物におけるSGLT2阻害薬、RAS阻害薬による糸球体血行動態変化の解析2021
- Author(s)
  和田佳久、城所研吾、近藤恵、佐々木環、柏原直樹
- Organizer
  第64回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] SGLT2阻害薬による内皮NOS機能異常改善を介した腎保護効果の検証2021
- Author(s)
  近藤恵、城所研吾、角谷裕之、和田佳久、長洲一、佐々木環、柏原直樹
- Organizer
  第21回日本NO学会
- Data Source
  KAKENHI-PROJECT-21H02937
[Presentation] Evaluation of glomerular hemodynamic changes by SGLT2 inhibitor and ARB in type 2 diabetic rats using in vivo imaging2021
- Author(s)
  Yoshihisa Wada,Kengo Kidokoro,Reina Umeno,Atsuyuki Tokuyama,Megumi Kondo,Hiroyuki Kadoya, Hajime Nagasu,Tamaki Sasaki,Naoki Kashihara
- Organizer
  The 10th Chronic Kidney Disease Frontier Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] 内皮機能障害はinflammasome活性化を介して老化関連腎障害を促進させる。2020
- Author(s)
  長洲一、和田佳久、近藤恵、徳山敦之、角谷裕之、城所研吾、長洲一、柏原直樹
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] ENOS/NO SIGNALLING ATTENUATES GLOMERULAR INJURY IN DIABETIC MICE VIA SUPPRESSION OF INFLAMMASOME ACTIVATION2020
- Author(s)
  Nagasu H,Wada Y,Kadoya H,Kidokoro K,Kashihara N.
- Organizer
  the 18th Asian Pacific Congress of Nephrology (APCN 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] EVALUATION OF THE MECHANISM OF GLOMERULAR ARTERIOLE CHANGES BY SGLT2 INHIBITION IN TYPE 2 DIABETIC RATS2020
- Author(s)
  Nagasu H,Wada Y,Kidokoro K,Kadoya H,Kashihara N.
- Organizer
  the 18th Asian Pacific Congress of Nephrology (APCN 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] 2型糖尿病モデル動物におけるSGLT2阻害薬による糸球体血行動態変化とその機序解明2020
- Author(s)
  和田佳久、城所研吾、佐々木環、柏原直樹
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] 糖尿病性腎臓病におけるSGLT2阻害薬Canagliflozinの糸球体内皮機能改善効果の検討2020
- Author(s)
  近藤恵、城所研吾、和田佳久、徳山敦之、角谷裕之、長洲一、佐々木環、柏原直樹
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] DEFICIENT OF ENOS/NO PATHWAY PROMOTES AKI TO CKD TRANSITION AFTER ISCHEMIC REPERFUSION2020
- Author(s)
  Nagasu N,Kondo M,Kadoya H,Kidokoro K,Kashihara N.
- Organizer
  the 18th Asian Pacific Congress of Nephrology (APCN 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] 新たなin vivoイメージング技術から明らかになった、タダラフィルによる腎虚血/再灌流後好中球浸潤低下(The novel in vivo imaging techniques for visualizing neutrophil infiltration following renal ischemia/reperfusion which was reduced by tadalafil)2020
- Author(s)
  丸山雄樹, 荒木元朗, 城所研吾, 十川裕史, 吉永香澄, 光井洋介, 定平卓也, 和田耕一郎, 渡部昌実, 渡邉豊彦, 柏原直樹, 那須保友
- Organizer
  第72回西日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-19K09711
[Presentation] THE EFFECTS OF SGLT2 INHIBITORS ON GLOMERULAR HYPERFILTRATION AND OXIDATIVE STRESS IN MICE WITH DIABETIC KIDNEY DISEASE2020
- Author(s)
  Kondo M,Kidokoro K,Nagasu H,Sasaki T,Kashihara N.
- Organizer
  the 18th Asian Pacific Congress of Nephrology (APCN 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Keap1/Nrf2経路によるGFR制御機構の解明2020
- Author(s)
  城所研吾、佐々木環、柏原直樹
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Bardoxolone methyl analog attenuates proteinuria-induced tubular damege by modulating mitochondrial function.2019
- Author(s)
  Nagasu H, Sogawa Y, Kidokoro K, Wigley W, Prokcsh J, Meyer C, Satoh M, Kashihara N
- Organizer
  ISN World Congress of Nephrology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] 腎虚血再灌流障害における好中球動態の二光子励起顕微鏡を用いた解析2019
- Author(s)
  丸山雄樹城所研吾　荒木元朗
- Organizer
  日本移植学会総会
- Data Source
  KAKENHI-PROJECT-19K09711
[Presentation] Evaluation of the diabetic glomerular hemodynamics by SGLT2 inhibitor empagliflozin using in vivo imaging.2019
- Author(s)
  K Kidokoro, D Cherney, A Bozovic, H Nagasu, M Satoh, T Sasaki, N Kashihara.
- Organizer
  ISN World Congress of Nephrology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Effect of uremic toxin-indoxcyl sulfate on intestinal defensin expression in renal failure mice.2019
- Author(s)
  M Satoh, M Kondo, Y Wada, S Itano, K Kidokoro, H Nagasu, T Sasaki, N Kashihara.
- Organizer
  ISN World Congress of Nephrology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] 内皮eVOS/NO/PKG経路はWnt/βcatenin活性化を負に制御し、M1/M2マクロファージ分化誘導を介して、AKI to CKD transitonに関与する2019
- Author(s)
  近藤恵、長洲一、和田佳久、角谷裕之、城所研吾、佐藤稔、佐々木環、柏原直樹
- Organizer
  第10回分子腎臓フォーラム
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Clarification of the Mechanism of Acute GFR Change by SGLT2 Inhibition with In Vivo Imaging Technique2019
- Author(s)
  Wada Y, Kidokoro K, Kondo M , Tokuyama A, Kadoya H, Nagasu H, Satoh M, Sasaki T, Kashihara N
- Organizer
  ASN　Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Bardoxolone methyl analog attenuates proteinuria-induced tubular damege by modulating mitochondrial function.2019
- Author(s)
  H Nagasu, Y Sogawa, K Kidokoro, W Wigley, J Prokcsh, C Meyer, M Satoh, N Kashihara.
- Organizer
  ISN World Congress of Nephrology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Investigation of the suppressive effects of an SGLT2 inhibitor on glomerular hyperfiltration and oxidative stress in mice with diabetic kidney disease.2019
- Author(s)
  Kidokoro K, Kondo M, Satoh M, Sasaki T, Kashihara N
- Organizer
  56th ERA-EDTA Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Endothelial Nitric Oxide Synthase/Nitric Oxide Pathway Underlies the Mechanisms of AKI to CKD Transition via Prolonged Activation of the Wnt/β-Catenin Pathway2019
- Author(s)
  Kondo M, Nagasu H, Sogawa Y, Kadoya H, Kidokoro K, Satoh M, Kashihara N
- Organizer
  ASN　Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Activation of the Keap1/Nrf2 Pathway Increases GFR by Increasing Glomerular Effective Filtration Area Without Affecting the Afferent/Efferent Arteriole Ratio2019
- Author(s)
  Kidokoro K,Nagasu H, Satoh M, Meyer C, Kashihara N
- Organizer
  ASN　Kidney Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Evaluation of the glomerular hemodynamics alterations by SGLT2 inhibitor Empagliflozin using in vivo imaging.2018
- Author(s)
  K Kidokoro、A Uchida ,Y Sogawa,H Nagasu, Msatoh, T Sasaki, N Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Endothelial dysfunction exacerbates renal tubular cell injury through inflammasome activation in a hypertensive mouse model.2018
- Author(s)
  Yuji Sogawa, Hajime Nagasu, Megumi Kondo, Yoshihisa Wada, Hiroyuki Kadoya, Kengo Kidokoro, Minoru Satoh, Tamaki Sasaki, Naoki Kashihara.
- Organizer
  ASN KIDNEY WEEK 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] RTAdh404 attenuates renal inflammation and fibrosis via mitochondrial protection in ICGN mice.2018
- Author(s)
  Y Sogawa,H Nagasu,A Uchida,S Itano,K Kidokoro,Y Haruna,M Satoh,T Sasaki,N Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] The association of microbiota alteration and intestinal barrier function in chronic renal failure mice2018
- Author(s)
  Minoru Satoh, Seiji Itano,Yuji Sogawa, Y Haruna, K kidokoro, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] eNOS -NO signaring attenuates renal fibrosis via suppression of catenin signaling.2018
- Author(s)
  H Nagasu, Y Sogawa, K Kidokoro, S Itano, M Satoh, T Sasaki, N Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] The eNOS/NO signaring attenuates glomerular injury in diabetic mice via suppression of inflammasome activation.2018
- Author(s)
  Y Sogawa,　H Nagasu,A Uchida,S Itano,K Kidokoro,Y Haruna,M Satoh,Ti Sasaki,N Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] DPP4 inhibitor linagliptin ameliorates diabetic kidneydisease through the protection of glomerular endothelial function in mice.2018
- Author(s)
  K Kidokoro、A Uchida ,Y Sogawa,H Nagasu, Msatoh, T Sasaki, N Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] 5-aminolevulinic acid exerts renoprotective effect via Nrf2 activation in rhabdomyolysis-induced acute kidney injury .2018
- Author(s)
  K Kidokoro, A Uchida,Y Sogawa, S Itano, M Satoh,T Sasaki N Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Evaluation of glomerular hemodynamic function by empagliflozin in diabetic mice using in vivo imaging.2018
- Author(s)
  Kengo kidokoro, Yuji Sogawa, Cherney D, Kulasingan V, Hajime Nagasu, Minoru Satoh, Tamaki Sasaki, Naoki Kashihara
- Organizer
  American Diabetes Association 78th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Evaluation of the glomerular hemodynamis by the SGLT2 inhibitor empagliflozin using in vivo imaging.2018
- Author(s)
  Kengo Kidokoro, Yoshihisa Wada, Megumi Kondo, Yuji Sogawa, Hajime Nagasu, Minoru Satoh, Tamaki　Sasaki, Naoki Kashihara.
- Organizer
  55th ERA-EDTA Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] Non-purine selective xanthine oxidase inhibitor ameliorates glomerular endothelial injury in Ins2Akita diabetic mice2018
- Author(s)
  Minoru Satoh, Seiji Itano, Yuji Sogawa, Athushi Uchida,K Kidokoro, H Nagasu, Y Haruna, Tamaki Sasaki, Naoki Kashihara
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Nrf2 Activator, RTADh404, attenuates renal tubular Injury via Mitochondrial Protection in nephrotic model mice.2018
- Author(s)
  Yuji Sogawa, Hajime Nagasu, Megumi Kondo, Yoshihisa Wada, Kengo Kidokoro, Yoshisuke Haruna, Minoru Satoh, Tamaki Sasaki, Naoki Kashihara.
- Organizer
  55th ERA-EDTA Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02828
[Presentation] DPP-4阻害剤Linagliptinは血糖非依存性の内皮保護作用によりアルブミン尿を減少させる2017
- Author(s)
  内田篤志、十川裕史、板野精之、城所研吾、長洲一、佐藤、佐々木、柏原直樹
- Organizer
  第6回臨床高血圧フォーラム
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Evaluation of the effect of empagliflozin on improving hyperfiltration in diabetic nephropathy2017
- Author(s)
  Y. Sogawa, K. Kidokoro, A. Uchida, S. Itano, H. Nagasu, M. Satoh, T. Sasaki, N. Kashihara
- Organizer
  53RD ANNUAL MEETING OF THE EUROPEAN ASSOCIATION FOR THE STUDY OF DIABETES(EASD2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] ネフローゼ腎不全マウスの筋力低下に対する自発的車輪ランニングの効果2017
- Author(s)
  十川裕史、花田里美、内田篤志、板野精之、城所研吾、長洲一、佐藤稔、佐々木環、柏原直樹
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] 内皮由来可溶性糖タンパクであるエンドカンの内皮細胞へ作用の検討2017
- Author(s)
  佐藤稔、花田里美、桑原篤憲、長洲一、城所研吾、佐々木環、柏原直樹
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] 糖尿病においてeNOS/NO経路はインフラマソーム活性化の抑制を介して支給対象外を軽減する2017
- Author(s)
  十川裕史、長洲一、内田篤志、板野精之、城所研吾、佐藤稔、佐々木環、柏原直樹
- Organizer
  第6回臨床高血圧フォーラム
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] eNOS/NOシグナルはインフラマソーム抑制を介して糖尿病性腎症における糸球体障害の進展を軽減する2017
- Author(s)
  十川裕史、内田篤志、城所研吾、長洲一、佐藤稔、佐々木環、柏原直樹
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] 横紋筋融解症においてNrf2活性化は尿細管抗酸化遺伝子群発現抑制を介して腎保護作用を有する2017
- Author(s)
  内田篤志、花田里美、十川裕史、城所研吾、長洲一、佐藤稔、佐々木環、柏原直樹
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Development of a Novel Model of Contrast-Induced AKI in Mice2017
- Author(s)
  Uchida A, Kidokoro K, Nagasu H, Satoh M, Sasaki T, Kashihara N.
- Organizer
  ASN Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] in vivo imagingを用いたSGLT2阻害薬Empagliflozinの糖尿病性腎障害抑制機序の解明2017
- Author(s)
  城所研吾、十川裕史、内田篤志、長洲一、佐藤稔、佐々木環、柏原直樹
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Evaluation of the Reno-Protective Effects of Empagliflozin in Diabetic Nephropathy Using In Vivo Imaging2017
- Author(s)
  Kidokoro K, Uchida A, Sogawa Y, Nagasu H, Satoh M, Sasaki T, Kashihara N
- Organizer
  ASN Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] 虚血再灌流モデルにおいてeNOS-NO経路の破綻はAKI-CKD transitionを促進させる2017
- Author(s)
  長洲一、内田篤志、十川祐史、城所研吾、佐藤稔、佐々木環、柏原直樹
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] UUOモデルではNrf2欠損状態は腎内への炎症性マクロファージ持続浸潤を抑制する2017
- Author(s)
  十川裕史、長洲一、花田里美、内田篤志、板野精之、城所研吾、佐藤稔、佐々木環、柏原直樹
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Renoprotective Effect of 5-Aminolevulinic Acid in Rhabdomyolysis-Induced Acute Kidney Injury2016
- Author(s)
  Atsushi Uchida, Kengo Kidokoro, Hajime Nagasu, Minoru Satoh,Tamaki Sasaki, Naoki Kashihara
- Organizer
  第15回アジア太平洋腎臓学会（APCN2016) 15th Asian Pacific Congress of Nephrology & 52nd Australian and New Zealand Society of Nephrology ASM
- Place of Presentation
  Perth Convention and Exhibition Centre(Perth /Australia)
- Year and Date
  2016-09-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] The Association and Its Mechanism between Microbiota Alteration and Intestinal-Barrier Function in Mice with Chronic Renal Failure2016
- Author(s)
  Seiji Itano, Minoru Satoh, Yuji Sogawa, Atsushi Uchida, Kengo Kidokoro, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara.
- Organizer
  ASN KIDNEY WEEK2016
- Place of Presentation
  Chicago, Illinois, United States
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Effects of Lanthanum Carbonate on Intestinal Bacterial Flora and Intestinal Barrier Function in Chronic Renal Failure Mice2016
- Author(s)
  Seiji Itano,Minoru Satoh,Atsushi Uchida,Yuji Sogawa,Hajime Nagasu,Kengo Kidokoro,Tamaki Sasaki,Naoki Kashihara
- Organizer
  第15回アジア太平洋腎臓学会（APCN2016) 15th Asian Pacific Congress of Nephrology & 52nd Australian and New Zealand Society of Nephrology ASM
- Place of Presentation
  Perth Convention and Exhibition Centre(Perth /Australia)
- Year and Date
  2016-09-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838
[Presentation] Visualization of in vivo renin activity and its application to study the pathogenetic mechanisms of diabetic nephropathy.2015
- Author(s)
  Minoru Satoh, Kengo Kidokoro, Seiji Itano, Hajime Nagasu, Tamaki Sasaki, Naoki Kashihara
- Organizer
  10th World Congress for Microcirculation
- Place of Presentation
  Kyoto International Conference Center,Kyoto
- Year and Date
  2015-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04838

1. Nagasu Hajime (40412176)

# of Collaborated Projects: 10 results

# of Collaborated Products: 59 results
2. Kashihara Naoki (10233701)

# of Collaborated Projects: 9 results

# of Collaborated Products: 73 results
3. Motoo Araki (90467746)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 佐藤稔 (70449891)

# of Collaborated Projects: 3 results

# of Collaborated Products: 42 results
5. 角谷裕之 (70509265)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
6. 岸誠司 (10519507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Yoshinaga Kasumi (70833276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 春名克祐 (40341094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 桑原篤憲 (50368627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 桐田雄平 (30783097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐々木環 (30187124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUZUKI Takafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. YAMAMOTO Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 谷口俊一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kidokoro Kengo 城所 研吾

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糖尿病性腎症におけるミネラルコルチコイド受容体活性による腎微小循環動態制御の解明Principal Investigator

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Elucidation of the role of the Keap1-Nrf2 mechanism in the regulation of glomerular filtration rate (GFR)Principal Investigator

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Evaluation of the role of endothelial pannexin1 in progression of diabetic kidney diseasePrincipal Investigator

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Review Section

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Elucidation of mechanism of the progression of glomerular injury via ATP/P2Y2 receptor pathway in diabetic kidney disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Kidokoro Kengo 城所研吾