Rokunohe Daiki 六戸大樹

… Alternative Names

ROKUNOHE Daiki 六戸大樹

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Researcher Number	50436036
Other IDs
Affiliation (Current)	2025: 弘前大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2025: 弘前大学, 医学部附属病院, 講師 2016 – 2020: 弘前大学, 医学研究科, 助教 2014 – 2015: 弘前大学, 医学(系)研究科(研究院), 助教 2012: 弘前大学, 医学(系)研究科(研究院), 助教 2011: 弘前大学, 医学(系)研究科(研究院), 研究員 … More 2010: Hirosaki University, 医学部・附属病院, 助手 2009 – 2010: Hirosaki University, 医学部附属病院, 助手 2008: Hirosaki University, 医学部・附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related Except Principal Investigator Dermatology
Keywords	Principal Investigator 皮膚悪性腫瘍 / 細胞増殖 / 皮膚腫瘍 / HPV / 皮膚発癌 / パピローマウイルス / 発癌 / ウイルス発癌 / 皮膚有棘細胞癌 / 分子標的薬 … More / 皮膚癌 / 遺伝子変異 / 紫外線障害 / 紫外線皮膚障害 / 寿命 / 再生学 / 皮膚炎症 / RNAi / MAPキナーゼ / 分子生物学 / 癌 / 転移 / 分化 / シグナル伝達 … More Except Principal Investigator 末梢血白血球 / Ⅶ型コラーゲン / 間葉系幹細胞 / VII型コラーゲン / 末梢血単核細胞 / 治療 / 角化 / 皮膚 / 遺伝病 / 遺伝子 Less

グルコーストランスポーターの抑制は乳房外パジェット病の進行を制御できるかPrincipal Investigator
- Principal Investigator
  
  六戸大樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hirosaki University
Role of human papilloma virus E6/E7 and CD55 positive cells in skin carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Rokunohe Daiki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hirosaki University
ヒトパピローマウイルスによる皮膚発癌機序の解明Principal Investigator
- Principal Investigator
  
  六戸大樹
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
COL7A1 expression in the peripheral blood mononuclear cells
- Principal Investigator
  
  NAKANO Hajime
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
The elucidation of mechanism of hyperkeratosis and development of protein replacement therapy in patients with Mal de Meleda.
- Principal Investigator
  
  Nakajima Koji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
Analyses of mutations in cancer-related genes in skin tumors for the development of personalized medicinePrincipal Investigator
- Principal Investigator
  
  Rokunohe Daiki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
Analyses of SIRT6 function in preventing ultraviolet B-induced skin damagesPrincipal Investigator
- Principal Investigator
  
  ROKUNOHE Daiki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
Analyses of suppressive effect of Raf kinase inhibitor protein on cutaneous squamous cell carcinoma progression, and consideration for therapeutic use.Principal Investigator
- Principal Investigator
  
  ROKUNOHE Daiki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University

All 2021 2020 2019 2017 2016 2015 2014 2013 2012 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Significance of IL36RN mutation analyses in the management of impetigo herpetiformis: A case report and review of published cases2021
- Author(s)
  Yoshikawa Miyuki、Rokunohe Daiki、Kimura Atsuko、Takahashi Mika、Korekawa Ayumi、Nakajima Koji、Nakano Hajime、Yokoyama Minako、Tanaka Kanji、Yokoyama Yoshihito、Sawamura Daisuke
- Journal Title
  
  The Journal of Dermatology
  
  Volume: - Issue: 5 Pages: 699-702
- DOI
  10.1111/1346-8138.15788
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08260
[Journal Article] Analysis of the mechanism underlying a mild phenotype of hereditary coproporphyria due to a homozygous missense mutation in the transcription initiation codon of the coproporphyrinogen III oxidase gene2020
- Author(s)
  Fukui Tomohisa、Akasaka Eijiro、Rokunohe Daiki、Matsuzaki Yasushi、Sawamura Daisuke、Kabashima Kenji、Nakano Hajime
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 100 Issue: 2 Pages: 156-159
- DOI
  10.1016/j.jdermsci.2020.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08665, KAKENHI-PROJECT-18K08260, KAKENHI-PROJECT-18K08261, KAKENHI-PROJECT-18K08286
[Journal Article] Occupational ionizing radiation-induced skin injury among orthopedic surgeons: A clinical survey2020
- Author(s)
  Asari Toru、Rokunohe Daiki、Sasaki Eiji、Kaneko Takahide、Kumagai Gentaro、Wada Kanichiro、Tanaka Sunao、Sawamura Daisuke、Ishibashi Yasuyuki
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: - Issue: 1 Pages: 266-271
- DOI
  10.1016/j.jos.2020.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08260
[Journal Article] The first Japanese case of familial porphyria cutanea tarda diagnosed by a UROD mutation2019
- Author(s)
  Matsui Akinobu、Akasaka Eijiro、Rokunohe Daiki、Matsuzaki Yasushi、Sawamura Daisuke、Nakano Hajime
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 93 Issue: 1 Pages: 65-67
- DOI
  10.1016/j.jdermsci.2018.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10224, KAKENHI-PROJECT-18K08261, KAKENHI-PROJECT-18K08260
[Journal Article] Nagashima‐type palmoplantar keratoderma and malignant melanoma in Japanese patients2019
- Author(s)
  Korekawa A, Akasaka E, Rokunohe D, Fukui T, Kaneko T, Sawamura D, Ishikawa M, Yamamoto T, Nakano H.
- Journal Title
  
  British Journal of Dermatology
  
  Volume: 180 Issue: 2 Pages: 415-416
- DOI
  10.1111/bjd.17251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08260
[Journal Article] Two Japanese familial cases of punctate palmoplantar keratoderma caused by a novel AAGAB mutation, c.191_194delCAAA.2015
- Author(s)
  Akasaka E, Okawa Y, Nakano H, Takiyoshi N, Rokunohe D, Toyomaki Y, Sawamura D, Sueki H.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 78 Issue: 2 Pages: 156-158
- DOI
  10.1016/j.jdermsci.2015.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670497, KAKENHI-PROJECT-25860929, KAKENHI-PROJECT-26293254, KAKENHI-PROJECT-26860865, KAKENHI-PROJECT-26461653, KAKENHI-PROJECT-15K19670
[Journal Article] Primary Amelanotic Rhabdoid Melanoma: A Case Report with Review of the Literature.2015
- Author(s)
  Kaneko T, Korekawa A, Akasaka E, Rokunohe D, Nakano H, Sawamura D
- Journal Title
  
  Case Rep Dermatol
  
  Volume: 7 Issue: 3 Pages: 292-297
- DOI
  10.1159/000441347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26860865
[Journal Article] Superficial epidermolytic ichthyosis caused by a novel KRT2 mutation.2015
- Author(s)
  Akasaka E, Minakawa S, Rokunohe D, Toyomaki Y, Matsuzaki Y, Sawamura D, Nakano H
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 79 Issue: 1 Pages: 182-184
- DOI
  10.1016/j.jdermsci.2015.04.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09739, KAKENHI-PROJECT-26461675, KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26860864
[Journal Article] Pemphigoid gestationis with prepartum flare.2014
- Author(s)
  Minakawa S, Kaneko T, Rokunohe D, Nakajima K, Matsuzaki Y, Nakano H, Hashimoto T, Sawamura D
- Journal Title
  
  J Dermatol
  
  Volume: 41 Issue: 9 Pages: 580-851
- DOI
  10.1111/1346-8138.12576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461653, KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-26461675
[Journal Article] Multiple aplasia cutis congenita lesions located along Blaschko's lines in a patient with tetralogy of Fallot-A.2012
- Author(s)
  Rokunohe D
- Journal Title
  
  J Dermatol Case Rep
  
  Volume: 6 Issue: 2 Pages: 40-42
- DOI
  10.3315/jdcr.2012.1096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591610, KAKENHI-PROJECT-23591611, KAKENHI-PROJECT-23791248, KAKENHI-PROJECT-24591621, KAKENHI-PROJECT-24659518
[Journal Article] Spindle cell hemangioma and decorin expression．2012
- Author(s)
  Daiki Rokunohe
- Journal Title
  
  Journal of Cosmetics, Dermatological Sciences and Applications
  
  Volume: 2 Issue: 01 Pages: 8-10
- DOI
  10.4236/jcdsa.2012.21002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390279, KAKENHI-PROJECT-23591610, KAKENHI-PROJECT-23591611, KAKENHI-PROJECT-23791248
[Journal Article] Raf kinase inhibitor protein expression correlates with differentiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma.2010
- Author(s)
  Rokunohe D, Nakano H, Akasaka E, Kimura K, Takiyoshi N, Nakajima K, Aizu T, Kaneko T, Matsuzaki Y, Tsuchida S, Sawamura D
- Journal Title
  
  J Dermatol Sci. 60
  
  Pages: 199-201
- NAID
  10027841189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591313
[Journal Article] Raf kinase inhibitor protein expression correlates with differe ntiation but not with ERK phosphorylation in cutaneous squamous cell carcinoma.2010
- Author(s)
  Rokunohe D, Nakano H, et al.
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 60 Pages: 199-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591313
[Presentation] BRAF・MEK阻害薬のリチャレンジが奏功した進行期悪性黒色腫2021
- Author(s)
  六戸大樹，相樂千尋，中野　創，澤村大輔，金子高英
- Organizer
  第36回日本皮膚悪性腫瘍学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08260
[Presentation] 灰黒色調を呈した下眼瞼表皮嚢腫2020
- Author(s)
  吉川未雪, 六戸大樹, 高橋実か, 是川あゆ美, 中島康爾, 中野創, 澤村大輔
- Organizer
  日本皮膚科学会東部支部学術大会
- Data Source
  KAKENHI-PROJECT-18K08260
[Presentation] Dabrafenib+Trametinib併用療法によって生じた発熱性好中球減少症2019
- Author(s)
  金子高英、福井智久、相樂千尋、滝吉典子、六戸大樹、会津隆幸、澤村大輔、須賀康
- Organizer
  第35回日本皮膚悪性腫瘍学会
- Data Source
  KAKENHI-PROJECT-18K08260
[Presentation] ニボルマブ/イピリムマブ併用療法後に重症筋無力症を生じた悪性黒色腫　当科での併用療法のまとめとともに2019
- Author(s)
  六戸大樹、金子高英、古川和仁、相樂千尋、中野創、澤村大輔
- Organizer
  第35回日本皮膚悪性腫瘍学会
- Data Source
  KAKENHI-PROJECT-18K08260
[Presentation] Nagashima-type palmoplantar keratoderma: A possible soil of melanoma.2017
- Author(s)
  Korekawa A, Akasaka E, Rokunohe D, Fukui T, Makita E, Sawamura D, Sawamura D
- Organizer
  第31回表皮細胞研究会
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] Symplastic glomus tumorの1例2016
- Author(s)
  六戸大樹、金子高英、牧田瑛子、櫻庭裕佑、萩原千尋、中野　創、澤村大輔
- Organizer
  日本皮膚科学会岩手地方会第373回例会
- Place of Presentation
  マリオス（岩手県盛岡市）
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-26860865
[Presentation] HPV16を検出した外陰部Bowen癌の1例～当科で経験した外陰部原発有棘細胞癌およびBowen病のHPV検索結果を含めて～．2015
- Author(s)
  六戸大樹、金子高英、松井彰伸、牧田瑛子、黒川景子、金城千尋、是川あゆ美、六戸亜希子、中野創、澤村大輔
- Organizer
  第67回日本皮膚科学会西部支部学術大会
- Place of Presentation
  長崎ブリックホール／長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26860865
[Presentation] 当科で治療した皮膚腫瘍症例について2015
- Author(s)
  六戸大樹
- Organizer
  第121回弘前皮膚科専門医会
- Place of Presentation
  ホテルナクアシティ弘前（青森県弘前市）
- Year and Date
  2015-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-26860865
[Presentation] 長島型掌蹠角化症型の遺伝子診断2014
- Author(s)
  櫻庭裕佑、赤坂英二郎、六戸大樹、中野創、澤村大輔
- Organizer
  第29回角化症研究会
- Place of Presentation
  東京商工会議所（東京）
- Year and Date
  2014-08-02
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] 放射線角化症の2例2013
- Author(s)
  金子高英、六戸亜希子、六戸大樹、中島康爾、会津隆幸、中野創、澤村大輔
- Organizer
  第81回日本皮膚科学会茨城地方会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-23791248
[Presentation] 原発不明悪性黒色の4例2012
- Author(s)
  金子高英、福井智久、六戸亜希子、是川あゆ美、六戸大樹、中島康爾、会津隆幸、中野創、澤村大輔、原田研
- Organizer
  第76回日本皮膚科学会東部支部学術大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23791248
[Presentation] 白斑黒皮症を呈した慢性光線性皮膚炎の1例2012
- Author(s)
  金子高英、六戸大樹、六戸亜希子、中野創、澤村大輔
- Organizer
  日本皮膚科学会青森地方会第358回例会
- Place of Presentation
  弘前市
- Year and Date
  2012-04-08
- Data Source
  KAKENHI-PROJECT-23791248
[Presentation] 踵に生じミルメシア様の外観を呈した顆粒細胞腫の1例2012
- Author(s)
  六戸大樹、金子高英、六戸亜希子、竹内園子、木村一之、中野創、澤村大輔、板井恒二
- Organizer
  第76回日本皮膚科学会東部支部学術大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23791248
[Presentation] アダリムマブ投与後に掌蹠膿疱症が再燃し全身に膿疱が多発した関節リウマチの1例2012
- Author(s)
  六戸大樹、北村英夫,原田研、金澤洋、三上幸子
- Organizer
  日本皮膚科学会青森地方会第358回例会
- Place of Presentation
  弘前市
- Year and Date
  2012-04-08
- Data Source
  KAKENHI-PROJECT-23791248
[Presentation] 踵に生じミルメシア様の外観を呈した顆粒細胞腫の1例2012
- Author(s)
  六戸大樹
- Organizer
  第76回日本皮膚科学会東部支部学術大会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-23791248
[Presentation] Raf kinase inhibitor protein expression correlate with differentiation without affecting the MAPK pathway activity in cutaneous SCC2009
- Author(s)
  六戸大樹
- Organizer
  The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-20591313
[Presentation] 古典的MAPキナーゼ抑制タンパクRKIPの皮膚有棘細胞癌における役割2009
- Author(s)
  六戸大樹
- Organizer
  第25回日本皮膚悪性腫瘍学会学術大会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-20591313
[Presentation] 古典的MAPキナーゼ抑制タンパクRKIPの皮膚有棘細胞癌における役割2009
- Author(s)
  六戸大樹
- Organizer
  第25回日本皮膚悪性腫瘍学会学術大会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-20591313
[Presentation] Raf kinase inhibitor protein expression correlate with differentiation without affecting the MAPK pathway activity in cutaneous SCC.2009
- Author(s)
  六戸大樹
- Organizer
  The 34^<th> annual meeting of the Japanese Society for Investigative Dermatology.
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-20591313
[Presentation] 古典的MAPキナーゼ抑制タンパクRKIPの皮膚有棘細胞癌における役割2008
- Author(s)
  六戸大樹
- Organizer
  第15回分子皮膚科学フォーラム
- Place of Presentation
  京都
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-20591313
[Presentation] アダリムマブ投与後に掌蹠膿疱症が再燃し全身に膿疱が多発した関節リウマチの1例
- Author(s)
  六戸大樹
- Organizer
  日本皮膚科学会青森地方会第358回例会
- Place of Presentation
  ホテルニューキャッスル（青森県）
- Data Source
  KAKENHI-PROJECT-23791248

1. NAKANO Hajime (90281922)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. 赤坂英二郎 (30436034)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. MATSUZAKI Yasushi (50322946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. Nakajima Koji (70374832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 澤村大輔 (60196334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 沢村大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
7. 金子高英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Rokunohe Daiki 六戸 大樹

ROKUNOHE Daiki 六戸 大樹

Research Projects

Research Products

Co-Researchers

グルコーストランスポーターの抑制は乳房外パジェット病の進行を制御できるかPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of human papilloma virus E6/E7 and CD55 positive cells in skin carcinogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトパピローマウイルスによる皮膚発癌機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

COL7A1 expression in the peripheral blood mononuclear cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of mechanism of hyperkeratosis and development of protein replacement therapy in patients with Mal de Meleda.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of mutations in cancer-related genes in skin tumors for the development of personalized medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of SIRT6 function in preventing ultraviolet B-induced skin damagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of suppressive effect of Raf kinase inhibitor protein on cutaneous squamous cell carcinoma progression, and consideration for therapeutic use.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Significance of IL36RN mutation analyses in the management of impetigo herpetiformis: A case report and review of published cases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the mechanism underlying a mild phenotype of hereditary coproporphyria due to a homozygous missense mutation in the transcription initiation codon of the coproporphyrinogen III oxidase gene2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Occupational ionizing radiation-induced skin injury among orthopedic surgeons: A clinical survey2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The first Japanese case of familial porphyria cutanea tarda diagnosed by a UROD mutation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nagashima‐type palmoplantar keratoderma and malignant melanoma in Japanese patients2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Japanese familial cases of punctate palmoplantar keratoderma caused by a novel AAGAB mutation, c.191_194delCAAA.2015

Author(s)

Rokunohe Daiki 六戸大樹

ROKUNOHE Daiki 六戸大樹

[Presentation] ニボルマブ/イピリムマブ併用療法後に重症筋無力症を生じた悪性黒色腫　当科での併用療法のまとめとともに2019