MATSUZAKI Hitomi 松崎仁美

… Alternative Names

松崎仁美マツザキヒトミ

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Researcher Number	50436242
Other IDs
Affiliation (Current)	2025: 筑波大学, 生命環境系, 助教
Affiliation (based on the past Project Information) *help	2023: 筑波大学, 生命環境系, 助教 2014 – 2021: 筑波大学, 生命環境系, 助教 2019: 筑波大学, 生命環境科学研究科(系), 助教
Review Section/Research Field	Principal Investigator Genetics/Chromosome dynamics / Basic Section 43010:Molecular biology-related / Biological Sciences
Keywords	Principal Investigator エピジェネティクス / DNAメチル化 / ゲノム刷り込み / 非対称性DNAメチル化 / 発現制御 / 遺伝子

Research Projects
(6 results)
Research Products
(26 results)

ゲノム刷り込みの階層性制御におけるシス配列トポロジーの役割Principal Investigator
- Principal Investigator
  
  松崎仁美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  University of Tsukuba
受精後刷り込みメチル化によるゲノム機能制御の普遍性とその進化的意味の検証Principal Investigator
- Principal Investigator
  
  松崎仁美
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  University of Tsukuba
Mechanisms of intergenerational transfer of epigenetic marks in mammalsPrincipal Investigator
- Principal Investigator
  
  MATSUZAKI Hitomi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  University of Tsukuba
哺乳類の正常発生を支える非対称性DNAメチル化維持機構の解明Principal Investigator
- Principal Investigator
  
  松崎仁美
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Search for germline epigenetic information that induces post-fertilization imprinted methylationPrincipal Investigator
- Principal Investigator
  
  Matsuzaki Hitomi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  University of Tsukuba
Molecular mechanisms of epigenetic regulation at the mouse imprinted locusPrincipal Investigator
- Principal Investigator
  
  MATSUZAKI Hitomi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  University of Tsukuba

All 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms2021
- Author(s)
  Matsuzaki Hitomi、Miyajima Yu、Fukamizu Akiyoshi、Tanimoto Keiji
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1410-1410
- DOI
  10.1038/s42003-021-02939-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05379
[Journal Article] Transient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation period2020
- Author(s)
  Hirakawa, K., Matsuzaki, H., and Tanimoto, K.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 29 Issue: 22 Pages: 3646-3661
- DOI
  10.1093/hmg/ddaa253
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05379, KAKENHI-PROJECT-19H03134
[Journal Article] Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus2020
- Author(s)
  Matsuzaki, H., Kuramochi, D., Okamura, E., Hirakawa, K., Ushiki, A., and Tanimoto, K.
- Journal Title
  
  Epigenetics & Chromatin
  
  Volume: 13 Issue: 1 Pages: 2-2
- DOI
  10.1186/s13072-019-0326-1
- NAID
  120007132843
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05012, KAKENHI-PROJECT-19H03134, KAKENHI-PROJECT-26292189
[Journal Article] Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice2018
- Author(s)
  Matsuzaki, H,. Okamura, E., Kuramochi, D., Ushiki, A., Hirakawa, K., Fukamizu, A., and Tanimoto, K.
- Journal Title
  
  Epigenetics & Chromatin
  
  Volume: 11 Issue: 1 Pages: 36-36
- DOI
  10.1186/s13072-018-0207-z
- NAID
  120006939623
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H05012, KAKENHI-PROJECT-26292189
[Journal Article] De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis2015
- Author(s)
  Matsuzaki, H., Okamura, E., Takahashi, T., Ushiki, A., Nakamura, T., Nakano, T., Hata, K., Fukamizu, A., and Tanimoto, K.
- Journal Title
  
  Development
  
  Volume: 142 Pages: 3833-3844
- DOI
  10.1242/dev.126003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26840113, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112006, KAKENHI-PUBLICLY-26112503, KAKENHI-PROJECT-26640063, KAKENHI-PROJECT-25291053, KAKENHI-PROJECT-26292189, KAKENHI-PROJECT-15H02509
[Presentation] ヒトH19-ICR YACトランスジェニック・マウスを用いた受精後刷り込みメチル化活性の検証2020
- Author(s)
  松崎仁美、平川勝彦、谷本啓司
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-20H05379
[Presentation] マウスH19-ICR配列のin vivo反転によるインプリント遺伝子発現機構の解明2020
- Author(s)
  松崎仁美、宮嶋優、谷本啓司
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-20H05379
[Presentation] YACトランスジェニック・マウスを用いたヒトH19-ICR刷り込みメチル化メカニズムの検証2019
- Author(s)
  平川勝彦、松崎仁美、谷本啓司
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] Reconstituted H19 ICR sequence with identified cis elements is capable of maintaining genomic imprinting in knock-in mouse2019
- Author(s)
  Matsuzaki, H., Kuramochi, D., Hirakawa, K., and Tanimoto, K.
- Organizer
  33rd International Mammalian Genome Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] マウスのゲノム刷り込み制御におけるH19-ICR配列反転の効果2019
- Author(s)
  宮嶋優、谷本啓司、松崎仁美
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] Test for imprinted DNA methylation activity of the human H19-ICR in YAC transgenic mice by adopting a transgene co-placement strategy2019
- Author(s)
  Hirakawa, K., Matsuzaki, H., and Tanimoto, K
- Organizer
  The 15th Transgenic Technology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] H19-ICR反転によるH19遺伝子転写制御機構のin vivo解析2018
- Author(s)
  宮嶋優、谷本啓司、松崎仁美
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] Imprinted gene expression can be reconstituted by synthetic DNA fragment composed of specified cis regulatory elements from the H19 ICR2018
- Author(s)
  Matsuzaki, H., Kuramochi, D., Hirakawa, K., and Tanimoto, K.
- Organizer
  Keystone Symposia (Gene Control in Development and Disease)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] Imprinted gene expression can be reconstituted by synthetic DNA fragment composed of specified cis regulatory elements from the H19 ICR2018
- Author(s)
  Matsuzaki, H., Kuramochi, D., Hirakawa, K., and Tanimoto, K.
- Organizer
  Keystone Symposia (Gene Control in Development and Disease)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] In vivo analysis of H19 gene transcriptional mechanism by inversion of the H19 imprinting control region2018
- Author(s)
  Matsuzaki, H., Miyajima, Y., and Tanimoto, K
- Organizer
  32nd International Mammalian Genome Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] 人工刷り込み制御配列によるゲノム刷り込みの再構築2017
- Author(s)
  倉持大地、松崎仁美、牛木亜季、谷本啓司
- Organizer
  第64回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-17H05012
[Presentation] Imprinted DNA methylation status can be reconstituted by combining activity of distinct H19 ICR elements in mice2016
- Author(s)
  松崎仁美、谷本啓司
- Organizer
  Mouse Genetics 2016 at The Allied Genetics Conference 2016
- Place of Presentation
  Orlando (USA)
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] マウスH19 ICR上流配列を介したアリル特異的DNAメチル化の検証2016
- Author(s)
  松崎仁美、倉持大地、谷本啓司
- Organizer
  第10回日本エピジェネティクス研究会年会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府・豊中市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] 5’-segment of the H19 ICR confers ability to acquire post-fertilization allele-specific DNA methylation to artificial DNA sequences2016
- Author(s)
  Matsuzaki, H. and Tanimoto, K.
- Organizer
  International Symposium on Epigenome Dynamics and Regulation in Germ Cells
- Place of Presentation
  京都大学（京都府・京都市）
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] 受精後アリル特異的de novo DNAメチル化によるゲノム刷り込み制御2016
- Author(s)
  松崎仁美
- Organizer
  第10回日本エピジェネティクス研究会年会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府・豊中市）
- Year and Date
  2016-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] マウスにおける再構築刷り込みメチル化配列の活性の検証2015
- Author(s)
  松崎仁美、倉持大地、谷本啓司
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] 刷り込みメチル化配列の再構築2015
- Author(s)
  松崎仁美、谷本啓司
- Organizer
  第9回日本エピジェネティクス研究会年会
- Place of Presentation
  学術総合センター一橋講堂（東京都・千代田区）
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] De novo DNA methylation mediated by 5' portion of the H19 ICR is essential for maintaining its methylation imprint during early embryogenesis in mice2015
- Author(s)
  Tanimoto, K., Matsuzaki, H., Okamura, E., Ushiki, A., and Takahashi, T.
- Organizer
  Mouse Molecular Genetics 2015
- Place of Presentation
  Cambridge (UK)
- Year and Date
  2015-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] マウスH19 ICRにおける受精後アリル特異的DNAメチル化活性の解析
- Author(s)
  松崎仁美、岡村永一、牛木亜季、高橋拓也、谷本啓司
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京大学伊藤国際学術研究センター（東京都・文京区）
- Year and Date
  2014-05-25 – 2014-05-27
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] Igf2/H19刷り込み遺伝子座における受精後アリル特異的DNAメチル化活性の解析
- Author(s)
  松崎仁美、岡村永一、牛木亜季、高橋拓也、谷本啓司
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26840113
[Presentation] A role for postfertilization, allele-specific DNA methylation activity in maintaining the imprinted H19 ICR methylation
- Author(s)
  Matsuzaki, H., Okamura, E., Ushiki, A., Takahashi, T., Tanimoto, K.
- Organizer
  Keystone Symposia (DNA methylation)
- Place of Presentation
  Keystone (アメリカ合衆国)
- Year and Date
  2015-03-29 – 2015-04-03
- Data Source
  KAKENHI-PROJECT-26840113

MATSUZAKI Hitomi 松崎 仁美

松崎 仁美 マツザキ ヒトミ

Research Projects

Research Products

ゲノム刷り込みの階層性制御におけるシス配列トポロジーの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

受精後刷り込みメチル化によるゲノム機能制御の普遍性とその進化的意味の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of intergenerational transfer of epigenetic marks in mammalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

哺乳類の正常発生を支える非対称性DNAメチル化維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for germline epigenetic information that induces post-fertilization imprinted methylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of epigenetic regulation at the mouse imprinted locusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation period2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] ヒトH19-ICR YACトランスジェニック・マウスを用いた受精後刷り込みメチル化活性の検証2020

Author(s)

Organizer

Data Source

[Presentation] マウスH19-ICR配列のin vivo反転によるインプリント遺伝子発現機構の解明2020

Author(s)

Organizer

Data Source

[Presentation] YACトランスジェニック・マウスを用いたヒトH19-ICR刷り込みメチル化メカニズムの検証2019

Author(s)

Organizer

Data Source

[Presentation] Reconstituted H19 ICR sequence with identified cis elements is capable of maintaining genomic imprinting in knock-in mouse2019

MATSUZAKI Hitomi 松崎仁美

松崎仁美マツザキヒトミ