Chikuma Shunsuke 竹馬俊介

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CHIKUMA Shunsuke 竹馬俊介

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Researcher Number	50437208
Other IDs
Affiliation (Current)	2023: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2023: 慶應義塾大学, 医学部, 准教授 2020 – 2022: 慶應義塾大学, 医学部(信濃町), 准教授 2016 – 2019: 慶應義塾大学, 医学部(信濃町), 講師 2015: 慶應義塾大学, 医学部, 講師 2011 – 2014: 京都大学, 医学(系)研究科(研究院), 助教 2012: 京都大学, 医学研究科, 助教 2007 – 2010: Kyoto University, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Immunology / Biological Sciences / Basic Section 49030:Experimental pathology-related / Complex systems / General medical chemistry / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Transformative Research Areas, Section (III)
Keywords	Principal Investigator 免疫寛容 / 自己免疫疾患 / T細胞 / 自己免疫 / がん免疫 / 免疫制御 / Ｔ細胞 / 新規マウスモデル / 免疫学 / 免疫抑制 … More / 免疫記憶 / エピジェネティクス / 新規抗原 / ヘルパーT細胞 / メモリーT細胞 / エピトープ / T細胞活性化 / 抗原不応答性(アナジー) / ガン免疫 / 免疫抑制受容体 / 副刺激 / 抑制レセプター / 抑制受容体 / PD-1 / 遺伝子改変マウス / 免疫疲弊 / メモリーＴ細胞 / 遺伝子調節 / 抗原提示 / ヘルパーＴ細胞 / 慢性炎症 / クロマチン制御 / がん抗原 / 内在性レトロウイルス / 遺伝子サイレンシング / Tリンパ球 / Ｔリンパ球 / 免疫治療 Less

肝内Ｔ細胞の自己認識による「功」の解明Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
内在性レトロウイルス抑制因子による、がん免疫寛容機構の基盤研究Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Keio University
アバタセプト抵抗性「しつこい」記憶T細胞を除去する方法の探索Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Keio University
自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University
Mechanisms of long-term survival of self-reactive helper T cellsPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Shunsuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Keio University
クロマチン抑制因子の破綻によるネオセルフ生成Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University
遺伝子サイレンシング機構の破綻によるネオセルフ生成と、免疫活性化の検証Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Regulation of self-reactive T cells by TRIM28Principal Investigator
- Principal Investigator
  
  Chikuma Shunsuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Keio University
The mechanism of strong PD-1 expression leading to immuno-suppression.Principal Investigator
- Principal Investigator
  
  CHIKUMA SHUNSUKE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Keio University
  Kyoto University
PD-1 and novel immune-regulatory molecules in T cell differentiation.Principal Investigator
- Principal Investigator
  
  CHIKUMA Shunsuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
A novel molecule that regulates T-cell tolerance under PD-1.Principal Investigator
- Principal Investigator
  
  CHIKUMA Shunsuke
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Mechanistic basis for induction of T-cell anergy by PD-1, an immuno-regulatory receptorPrincipal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

[Book] TRIM28は内在性レトロウイルスの抑制を通じ、Ｔ細胞免疫の暴走を抑制する2022
- Author(s)
  竹馬　俊介
- Total Pages
  2
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-19K07488
[Book] TRIM28は内在性レトロウイルスの抑制を通じ、Ｔ細胞免疫の暴走を抑制する2022
- Author(s)
  竹馬　俊介
- Total Pages
  2
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Book] TRIM28 と自己免疫応答2013
- Author(s)
  竹馬俊介
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article] TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus2021
- Author(s)
  Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Pages: 1528-1539
- DOI
  10.4049/jimmunol.2001003
- Description
  in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06616, KAKENHI-PUBLICLY-19H04816, KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07488, KAKENHI-PUBLICLY-21H00439, KAKENHI-PROJECT-21H05044
[Journal Article] Tocilizumab monotherapy uncovered the role of the CCL22/17‐CCR4+Treg axis during remission of crescentic glomerulonephritis2020
- Author(s)
  Sakai R, Ito M, Yoshimoto K, Chikuma S, Kurasawa T, Kondo T, Suzuki K, Takeuchi T, Amano K, Yoshimura A
- Journal Title
  
  Clin Transl Immunology.
  
  Volume: 9
- DOI
  10.1002/cti2.1203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K08890, KAKENHI-PUBLICLY-19H04816, KAKENHI-PUBLICLY-19H04817, KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-19K16618
[Journal Article] Detection of singularity in immunity and cancer by novel imaging techniques2020
- Author(s)
  Nagai T, Chikuma S, Hanaoka K
- Journal Title
  
  BIOPHYSICS
  
  Volume: 17 Issue: 0 Pages: 98-99
- DOI
  10.2142/biophysico.bsj-2020018
  10.2142/biophysico.BSJ-2020018
- NAID
  130007919806
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PUBLICLY-19H05431
[Journal Article] The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.2020
- Author(s)
  Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Yoshimura A, et al
- Journal Title
  
  Cancer Res
  
  Volume: 80 Pages: 471-483
- DOI
  10.1158/0008-5472.can-19-1196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K07514, KAKENHI-PROJECT-19K23850, KAKENHI-PUBLICLY-19H04816, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-18K15290, KAKENHI-PROJECT-16H06276
[Journal Article] PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching2019
- Author(s)
  Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S
- Journal Title
  
  PloS one
  
  Volume: 14
- DOI
  10.1371/journal.pone.0213383
- NAID
  120006822506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02952, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19H04265
[Journal Article] Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma2019
- Author(s)
  Goto M, Chamoto K, Higuchi K, Yamashita S, Noda K, Iino T, Miura M, Yamasaki T, Ogawa O, Sonobe M, Date H, Hamanishi J, Mandai M, Tanaka Y, Chikuma S, Hatae R, Muto M, Minamiguchi S, Minato N, Honjo T
- Journal Title
  
  Sci Rep
  
  Volume: 9 Pages: 10144-10144
- DOI
  10.1038/s41598-019-46548-3
- NAID
  120006724630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-18H02945, KAKENHI-PROJECT-17K19591, KAKENHI-PROJECT-16H06149
[Journal Article] Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression2019
- Author(s)
  Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A
- Journal Title
  
  International Immunology
  
  Volume: 31 Pages: 335-347
- DOI
  10.1093/intimm/dxz008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K00562, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-16H06295
[Journal Article] Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery.2019
- Author(s)
  Ito Minako、Komai Kyoko、Mise-Omata Setsuko、Iizuka-Koga Mana、Noguchi Yoshiko、Kondo Taisuke、Sakai Ryota、Matsuo Kazuhiko、Nakayama Takashi、Yoshie Osamu、Nakatsukasa Hiroko、Chikuma Shunsuke、Shichita Takashi、Yoshimura Akihiko
- Journal Title
  
  Ｎａｔｕｒｅ
  
  Volume: 565 Pages: 246-250
- DOI
  10.1038/s41586-018-0824-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15129, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05514, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H05096, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-17K19571, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384
[Journal Article] In Vitro Conversion of Activated T Cells into Stem Cell Memory-Like T Cells.2019
- Author(s)
  Kondo T, Imura Y, Ando M, Chikuma S, Yoshimura A
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2048 Pages: 41-51
- DOI
  10.1007/978-1-4939-9728-2_4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07488
[Journal Article] Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy2018
- Author(s)
  Taisuke Kondo Yuki Imura Shunsuke Chikuma Sana Hibino Setsuko Omata‐Mise Makoto Ando Takashi Akanuma Mana Iizuka Ryota Sakai Rimpei Morita Akihiko Yoshimura
- Journal Title
  
  Cancer Sci
  
  Volume: 109 Pages: 2130-2140
- DOI
  10.1111/cas.13648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15290, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-17K19398, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16H05178
[Journal Article] Development and Functional Modulation of Regulatory T Cells by Transcription Factors and Epigenetics.2018
- Author(s)
  Kanamori M, Nakatsukasa H, Ito M, Chikuma S, Yoshimura A.
- Journal Title
  
  Cornea.
  
  Volume: 30 Pages: 357-373
- DOI
  10.1093/intimm/dxy043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667
[Journal Article] Inhibition of Nr4a receptors enhances anti-tumor immunity by breaking Treg-mediated immune tolerance2018
- Author(s)
  Hibino S, Chikuma S, Kondo T, Ito M, Nakatsukasa H, Omata-Mise S, Yoshimura A
- Journal Title
  
  Cancer Res.
  
  Volume: Epub Pages: 3027-3040
- DOI
  10.1158/0008-5472.can-17-3102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-18K15198, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-20K20384
[Journal Article] SOCS: potential immune checkpoint molecules for cancer immunotherapy(印刷中)2017
- Author(s)
  Chikuma S, Kanamori M, Mise-Omata S, Yoshimura A.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Pages: 574-580
- DOI
  10.1111/cas.13194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-16K09867
[Journal Article] Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells2017
- Author(s)
  Okada M, Chikuma S et al.
- Journal Title
  
  Cell Rep
  
  Volume: 20 Pages: 1017-1028
- DOI
  10.1016/j.celrep.2017.07.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15451, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06501, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-15K19128
[Journal Article] Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model.2017
- Author(s)
  Hidenori Kasahara, Taisuke Kondo, Hiroko Nakatsukasa, Shunsuke Chikuma, Minako Ito, Makoto Ando, Yutaka Kurebayashi, Takashi Sekiya, Taketo Yamada, Shinichiro Okamoto, Akihiko Yoshimura
- Journal Title
  
  Int Immunol.
  
  Volume: 29 Pages: 457-469
- DOI
  10.1093/intimm/dxx060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0114, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-16J07143
[Journal Article] Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation2017
- Author(s)
  2)Komai K, Shichita T, Ito M, Kanamori M, Chikuma S, Yoshimura A.
- Journal Title
  
  International Immunology
  
  Volume: in press Pages: 59-70
- DOI
  10.1093/intimm/dxx010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K19571, KAKENHI-PUBLICLY-17H05514, KAKENHI-PROJECT-17H05096
[Journal Article] CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation.2017
- Author(s)
  Chikuma S
- Journal Title
  
  Curr Top Microbiol Immunol
  
  Volume: 410 Pages: 99-126
- DOI
  10.1007/82_2017_61
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05801
[Journal Article] Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy2017
- Author(s)
  Chikuma S
- Journal Title
  
  Cancer Sci
  
  Volume: 21 Pages: 448-455
- DOI
  10.1007/s10147-016-0958-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847
[Journal Article] Basics of PD-1 in self-tolerance, infection, and cancer immunity.2016
- Author(s)
  Shunsuke Chikuma
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: Feb 10
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.2016
- Author(s)
  Zhang B, Chikuma S, Hori S, Fagarasan S, and Honjo T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 113 Pages: 8490-8495
- DOI
  10.1073/pnas.1608873113
- NAID
  120005819493
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04747, KAKENHI-PROJECT-16K08847
[Journal Article] Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.2015
- Author(s)
  Hamanishi, J., M. Mandai, T. Ikeda, M. Minami, A. Kawaguchi, T. Murayama, M. Kanai, Y. Mori, S. Matsumoto, S. Chikuma, N. Matsumura, K. Abiko, T. Baba, K. Yamaguchi, A. Ueda, Y. Hosoe, S. Morita, M. Yokode, A. Shimizu, T. Honjo, I. Konishi.
- Journal Title
  
  J. Clin. Oncol.
  
  Volume: 33 Pages: 4015-22
- DOI
  10.1200/jco.2015.62.3397
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08230, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-26253080, KAKENHI-PROJECT-25460363, KAKENHI-PROJECT-25462590, KAKENHI-PROJECT-26861324, KAKENHI-PROJECT-25293069, KAKENHI-PROJECT-26293359, KAKENHI-PROJECT-25500003
[Journal Article] Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22.2015
- Author(s)
  Sakaguchi R, Chikuma S, Shichita T, Morita R, Sekiya T, Ouyang W, Ueda T, Seki H, Morisaki H, Yoshimura A
- Journal Title
  
  Int Immunol.
  
  Volume: Dec 8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function2014
- Author(s)
  Stumpf M, Zhou X, Chikuma S, Bluestone JA
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 44 Pages: 1737-1746
- DOI
  10.1002/eji.201343891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models2014
- Author(s)
  Nguyen T, Xu J, Chikuma S, Hiai H, Kinoshita K, Moriya K, Koike K, Marcuzzi GP, Pfister H, Honjo T, Kobayashi M.
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Pages: 397-406
- DOI
  10.1093/intimm/dxu040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-25460363, KAKENHI-PROJECT-22000015
[Journal Article] Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response.2013
- Author(s)
  Rui Y, Honjo T, Chikuma S
- Journal Title
  
  PNAS
  
  Volume: 110 Pages: 16073-8
- DOI
  10.1073/pnas.1315828110
- NAID
  120005324915
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] A rheostat for immune responses : the unique properties of PD-1 and their advantages for clinical application2013
- Author(s)
  Taku Okazaki, Shunsuke Chikuma, Yoshiko Iwai, Sidonia Fagarasan, Tasuku Honjo.
- Journal Title
  
  Nat Immunol
  
  Volume: 14 Pages: 1212-1218
- DOI
  10.1038/ni.2762
- NAID
  120005527992
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113516, KAKENHI-PROJECT-24659151, KAKENHI-PROJECT-25293118, KAKENHI-PROJECT-25460363
[Journal Article]2012
- Author(s)
  Chikuma S, Suita N, Okazaki IM, Shibayama S, Honjo T
- Journal Title
  
  Nat. Immunol.
  
  Volume: 13 Pages: 596-603
- DOI
  10.1038/ni.2293
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article]2012
- Author(s)
  Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y.
- Journal Title
  
  J. Exp. Med
  
  Volume: 209 Pages: 1743-52
- URL
  http://jem.rupress.org/content/209/10/1743.long
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article] (*Equal contribution) IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity2011
- Author(s)
  Terawaki S, Chikuma S, Shibayama S, et al
- Journal Title
  
  J Immunol Vol.186
  
  Pages: 2772-2779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790465
[Journal Article] IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.2011
- Author(s)
  Terawaki S, Chikuma S, Shibayama S, et al.(Equal contribution)
- Journal Title
  
  The Journal of Immunology
  
  Volume: 186 Pages: 2772-2779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790465
[Journal Article]2011
- Author(s)
  Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong LT, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
- Journal Title
  
  Plos One
  
  Volume: 6
- URL
  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029141
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.2011
- Author(s)
  Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong le T, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article] PD-1-mediated suppression of IL-2 production induces CD8+T cell anergy in vivo2009
- Author(s)
  Chikuma S., et.al.
- Journal Title
  
  The Journal of Immunology 182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Identification of QTLs that modify peripheral neuropathy in NOD. H2b-Pdcd1-/- mice2009
- Author(s)
  Jiang, Yoshida, Nakaki, Terawaki, Chikuma S, et.al.
- Journal Title
  
  International Immunology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Identification of QTLs that modify peripheral neuropathy in NOD. H2b-Pdcd1-/- mice2009
- Author(s)
  Jiang F, Yoshida T, Nakaki F, Terawaki S, Chikuma S, Kato Y, Okazaki IM, Honjo T, Okazaki T
- Journal Title
  
  Int. Immunol. vol.21
  
  Pages: 499-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] The expression of differentiation markers in aquaporin deficient epidermis2009
- Author(s)
  Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, and Miyachi Y
- Journal Title
  
  Arch. Dermatol. Res. vol.301
  
  Pages: 245-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Honjo T PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo2009
- Author(s)
  Chikuma S, Terawaki S, Hayashi T, Nabeshima R, Yoshida T, Shibayama S, Okazaki T
- Journal Title
  
  J.Immunol Vol.182
  
  Pages: 6682-6689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790465
[Journal Article] PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo2009
- Author(s)
  Chikuma S, Terawaki S, Hayashi T, Nabeshima R, Yoshida T, Shibayama S, Okazaki T, Honjo T
- Journal Title
  
  J. Immunol. vol.182
  
  Pages: 6682-6689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.2007
- Author(s)
  Chikuma S and Bluestone JA
- Journal Title
  
  The European Journal of Immunology 37
  
  Pages: 1285-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Expression of CTLA-4 and FoxP3 in cis protects from lethal lymphoproliferative disease2007
- Author(s)
  Chikuma S, Bluestone J
- Journal Title
  
  Eur. J. Immunol. vol.37
  
  Pages: 1285-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2022
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　成果発表会
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2022
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　成果発表会
- Data Source
  KAKENHI-PROJECT-19K07488
[Presentation] T細胞寛容におけるクロマチン制御因子TRIM28の機能解析2021
- Author(s)
  竹馬　俊介
- Organizer
  第29回京都T細胞会議
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2021
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　特別プログラム講演
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05431
[Presentation] T細胞寛容におけるクロマチン制御因子TRIM28の機能解析2021
- Author(s)
  竹馬　俊介
- Organizer
  第29回京都T細胞会議
- Data Source
  KAKENHI-PROJECT-19K07488
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2021
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　特別プログラム講演
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04816
[Presentation] Singularity in Immunity: Immune-aging associates with a defect in Chromatin Regulation on Immune Cells.2020
- Author(s)
  Chikuma S
- Organizer
  日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05431
[Presentation] Pathogenesis of autoreactive Th17 cells is driven by homeostatic cytokines stimulated by commensal microbiota2017
- Author(s)
  Chikuma et al.
- Organizer
  The 5th annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08847
[Presentation] PD-1 inhibits inflammatory helper T-cell development through controlling the innate immune response2013
- Author(s)
  Rui Y, Honjo T, Chikuma S
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25460363
[Presentation] 抗 PD-1 抗体によるがん治療法2012
- Author(s)
  竹馬俊介
- Organizer
  日台癌のトランスレーショナル研究シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] 北海道大学獣医学部学術交流資金群講演会2012
- Author(s)
  竹馬俊介
- Organizer
  自己免疫疾患研究の最先端
- Place of Presentation
  札幌
- Year and Date
  2012-11-01
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] T cell-expression of Trim28 prevents development of auto-inflammatory T cells2011
- Author(s)
  Shunsuke Chikuma
- Organizer
  2nd CSI/JSI/KAI Joint Symposium on Immunology（日中韓免疫シンポジウム）(招待講演)
- Place of Presentation
  Osaka University（大阪府）
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] Type I interferon promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity2011
- Author(s)
  Shunsuke Chikuma
- Organizer
  98th Annual Meeting, The American Association of Immunologists
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-21790465
[Presentation] In search of molecules that regulate PD-1 mediated inhibition of T cell function.2010
- Author(s)
  Shunsuke Chikuma
- Organizer
  14^<th> International congress of Immunology Aug 23-27, 2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790465
[Presentation] In search of molecules that regulate PD-1 mediated inhibition of T cell function2010
- Author(s)
  Shunsuke Chikuma
- Organizer
  14th International congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21790465
[Presentation] Transcriptional mechanisms of mouse PD-1 gene2008
- Author(s)
  Terawaki S, Chikuma S, Okazaki T, Honjo T
- Organizer
  第38回日本免疫学会総会・学術集会, Vol.38, p.234
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] PD-1 induces T cell anergy by limiting autonomous IL-2 production2008
- Author(s)
  Chikuma S, Terawaki S, Okazaki T, Honjo T
- Organizer
  第38回日本免疫学会総会・学術集会, Vol.38, p.234
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] マウスPD-1の転写機構/Transcriptional Mechanisms of Mouse PD-1 Gene2008
- Author(s)
  Terawaki S, Chikuma S, et.al.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] PD-1 induces T cellanergy by limiting autonomous IL-2 production2008
- Author(s)
  Chikuma S., et.al.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] 核内因子TRIM28による自己炎症性T細胞の制御
- Author(s)
  竹馬　俊介
- Organizer
  北海道大学獣医学部　学術交流資金群講演会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] Analysis of PD-1 expression and function on innate immune cells
- Author(s)
  Chikuma S, Honjo T
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25460363
[Presentation] 抗PD-1抗体によるがん治療法
- Author(s)
  竹馬　俊介
- Organizer
  日台癌のトランスレーショナル研究シンポジウム
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23790534

1. MIYACHI Hitoshi (90599200)

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Chikuma Shunsuke 竹馬 俊介

CHIKUMA Shunsuke 竹馬 俊介

Research Projects

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Co-Researchers

肝内Ｔ細胞の自己認識による「功」の解明Principal Investigator

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内在性レトロウイルス抑制因子による、がん免疫寛容機構の基盤研究Principal Investigator

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アバタセプト抵抗性「しつこい」記憶T細胞を除去する方法の探索Principal Investigator

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自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator

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Mechanisms of long-term survival of self-reactive helper T cellsPrincipal Investigator

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クロマチン抑制因子の破綻によるネオセルフ生成Principal Investigator

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自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator

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遺伝子サイレンシング機構の破綻によるネオセルフ生成と、免疫活性化の検証Principal Investigator

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Regulation of self-reactive T cells by TRIM28Principal Investigator

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The mechanism of strong PD-1 expression leading to immuno-suppression.Principal Investigator

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PD-1 and novel immune-regulatory molecules in T cell differentiation.Principal Investigator

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A novel molecule that regulates T-cell tolerance under PD-1.Principal Investigator

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Mechanistic basis for induction of T-cell anergy by PD-1, an immuno-regulatory receptorPrincipal Investigator

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Chikuma Shunsuke 竹馬俊介

CHIKUMA Shunsuke 竹馬俊介