Chikuma Shunsuke 竹馬俊介

… Alternative Names

CHIKUMA Shunsuke 竹馬俊介

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Researcher Number	50437208
Other IDs	https://orcid.org/0009-0008-4529-8695
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 客員准教授
Affiliation (based on the past Project Information) *help	2024: 東京大学, 定量生命科学研究所, 客員准教授 2020 – 2023: 慶應義塾大学, 医学部(信濃町), 准教授 2016 – 2019: 慶應義塾大学, 医学部(信濃町), 講師 2015: 慶應義塾大学, 医学部, 講師 2011 – 2014: 京都大学, 医学(系)研究科(研究院), 助教 2012: 京都大学, 医学研究科, 助教 2007 – 2010: Kyoto University, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Immunology / Complex systems / Basic Section 49030:Experimental pathology-related / Biological Sciences / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Transformative Research Areas, Section (III) / General medical chemistry
Keywords	Principal Investigator 免疫寛容 / 自己免疫疾患 / T細胞 / がん免疫 / 自己免疫 / 新規マウスモデル / Ｔ細胞 / 免疫制御 / Ｔリンパ球 / T細胞活性化 … More / エピトープ / メモリーT細胞 / ヘルパーT細胞 / 新規抗原 / エピジェネティクス / 免疫記憶 / 免疫抑制 / 免疫学 / Tリンパ球 / 遺伝子サイレンシング / 内在性レトロウイルス / 免疫治療 / 代謝性疾患 / 自己認識 / がん抗原 / クロマチン制御 / 慢性炎症 / Th17 / ヘルパーＴ細胞 / 抗原提示 / 遺伝子調節 / メモリーＴ細胞 / 免疫疲弊 / 遺伝子改変マウス / PD-1 / 抑制受容体 / 抑制レセプター / 副刺激 / 免疫抑制受容体 / ガン免疫 / 抗原不応答性(アナジー) Less

肝内Ｔ細胞の自己認識による「功」の解明Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
  Keio University
In vivo deletion of abatacept-resistant persistent autoreactive memory T cellsPrincipal Investigator
- Principal Investigator
  
  Chikuma Shunsuke
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Keio University
内在性レトロウイルス抑制因子による、がん免疫寛容機構の基盤研究Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
  Keio University
自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University
Mechanisms of long-term survival of self-reactive helper T cellsPrincipal Investigator
- Principal Investigator
  
  CHIKUMA Shunsuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Keio University
クロマチン抑制因子の破綻によるネオセルフ生成Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University
遺伝子サイレンシング機構の破綻によるネオセルフ生成と、免疫活性化の検証Principal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Regulation of self-reactive T cells by TRIM28Principal Investigator
- Principal Investigator
  
  Chikuma Shunsuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Keio University
The mechanism of strong PD-1 expression leading to immuno-suppression.Principal Investigator
- Principal Investigator
  
  CHIKUMA SHUNSUKE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Keio University
  Kyoto University
PD-1 and novel immune-regulatory molecules in T cell differentiation.Principal Investigator
- Principal Investigator
  
  CHIKUMA Shunsuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
A novel molecule that regulates T-cell tolerance under PD-1.Principal Investigator
- Principal Investigator
  
  CHIKUMA Shunsuke
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University
Mechanistic basis for induction of T-cell anergy by PD-1, an immuno-regulatory receptorPrincipal Investigator
- Principal Investigator
  
  竹馬俊介
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

[Book] TRIM28は内在性レトロウイルスの抑制を通じ、Ｔ細胞免疫の暴走を抑制する2022
- Author(s)
  竹馬　俊介
- Total Pages
  2
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-19K07488
[Book] TRIM28は内在性レトロウイルスの抑制を通じ、Ｔ細胞免疫の暴走を抑制する2022
- Author(s)
  竹馬俊介
- Total Pages
  2
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-23K24114
[Book] 免疫系における内在性レトロウイルスの役割2022
- Author(s)
  竹馬俊介
- Total Pages
  6
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-23K24114
[Book] TRIM28は内在性レトロウイルスの抑制を通じ、Ｔ細胞免疫の暴走を抑制する2022
- Author(s)
  竹馬　俊介
- Total Pages
  2
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Book] TRIM28 と自己免疫応答2013
- Author(s)
  竹馬俊介
- Publisher
  医学のあゆみ
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article] Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition2024
- Author(s)
  Tokifuji Yukiko、Hayabuchi Hodaka、Sasaki Takashi、Hara-Chikuma Mariko、Hirota Keiji、Takahashi Hayato、Amagai Masayuki、Yoshimura Akihiko、Chikuma Shunsuke
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 1 Pages: 108646-108646
- DOI
  10.1016/j.isci.2023.108646
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19444, KAKENHI-PROJECT-22K19446, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-19H01026
[Journal Article] Disruption of post-thymic tolerance in skin-reactive TCR transgenic mice through the interaction of lymphopenia and intestinal microbiota.2024
- Author(s)
  Hayabuchi H, Tokifuji Y, Takahashi H, Amagai M, Yoshimura A, Chikuma S
- Journal Title
  
  International immunology
  
  Volume: - Issue: 8 Pages: 413-424
- DOI
  10.1093/intimm/dxae018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19446, KAKENHI-PROJECT-21H05044
[Journal Article] DNA-damaged podocyte-CD8 T?cell crosstalk exacerbates kidney injury by altering DNA methylation2023
- Author(s)
  Nakamichi Ran、Hishikawa Akihito、Chikuma Shunsuke、Yoshimura Akihiko、Sasaki Takashi、Hashiguchi Akinori、Abe Takaya、Tokuhara Tomoko、Yoshimoto Norifumi、Nishimura Erina Sugita、Hama Eriko Yoshida、Azegami Tatsuhiko、Nakayama Takashin、Hayashi Kaori、Itoh Hiroshi
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 4 Pages: 112302-112302
- DOI
  10.1016/j.celrep.2023.112302
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-22K19444, KAKENHI-PROJECT-22K19446, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-23K24114, KAKENHI-PROJECT-22K19511, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K24351
[Journal Article] A Protein Kinase D inhibitor suppresses AKT on T cells and antagonizes cancer immunotherapy by Anti-PD-12022
- Author(s)
  Miyamoto K, Hayabuchi H, Tokifuji Y, Ando M, Onishi N, Okamura T, Yoshimura A, *Chikuma S:　　A Protein Kinase D inhibitor suppresses AKT on T cells and antagonizes cancer immunotherapy by Anti-PD-1
- Journal Title
  
  International Immunology
  
  Volume: 34 Issue: 12 Pages: 609-619
- DOI
  10.1093/intimm/dxac035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19446, KAKENHI-PROJECT-22H04922, KAKENHI-PUBLICLY-21H00439, KAKENHI-PROJECT-23K24114
[Journal Article] TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus2021
- Author(s)
  Chikuma Shunsuke、Yamanaka Soichiro、Nakagawa So、Ueda Mahoko Takahashi、Hayabuchi Hodaka、Tokifuji Yukiko、Kanayama Masashi、Okamura Tadashi、Arase Hisashi、Yoshimura Akihiko
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 7 Pages: 1528-1539
- DOI
  10.4049/jimmunol.2001003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06616, KAKENHI-PUBLICLY-19H04816, KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07488, KAKENHI-PUBLICLY-21H00439, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-18H05279
[Journal Article] The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.2020
- Author(s)
  Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Nishimasu H, Nureki O, Ohmura M, Hayakawa N, Hishiki T, Uchibori R, Ozawa K, Yoshimura A
- Journal Title
  
  Cancer Res
  
  Volume: 80 Issue: 3 Pages: 471-483
- DOI
  10.1158/0008-5472.can-19-1196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K07514, KAKENHI-PROJECT-19K23850, KAKENHI-PUBLICLY-19H04816, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-18K15290, KAKENHI-PROJECT-16H06276
[Journal Article] Tocilizumab monotherapy uncovered the role of the CCL22/17-CCR4+ Treg axis during remission of crescentic glomerulonephritis2020
- Author(s)
  Sakai R, Ito M, Yoshimoto K, Chikuma S, Kurasawa T, Kondo T, Suzuki K, Takeuchi T, Amano K, Yoshimura A
- Journal Title
  
  Clin Transl Immunology
  
  Volume: 9 Issue: 11
- DOI
  10.1002/cti2.1203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K08890, KAKENHI-PUBLICLY-19H04816, KAKENHI-PUBLICLY-19H04817, KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-19K16618
[Journal Article] Detection of singularity in immunity and cancer by novel imaging techniques2020
- Author(s)
  Nagai T, Chikuma S, Hanaoka K
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 17 Issue: 0 Pages: 98-99
- DOI
  10.2142/biophysico.BSJ-2020018
- NAID
  130007919806
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07488, KAKENHI-PUBLICLY-19H05431
[Journal Article] In Vitro Conversion of Activated T Cells into Stem Cell Memory-Like T Cells.2019
- Author(s)
  Kondo T, Imura Y, Ando M, Chikuma S, Yoshimura A
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2048 Pages: 41-51
- DOI
  10.1007/978-1-4939-9728-2_4
- ISBN
  9781493997275, 9781493997282
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07488
[Journal Article] PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.2019
- Author(s)
  Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 3 Pages: e0213383-e0213383
- DOI
  10.1371/journal.pone.0213383
- NAID
  120006822506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02952, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19H04265
[Journal Article] Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression.2019
- Author(s)
  Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A
- Journal Title
  
  International immunology
  
  Volume: 31 Issue: 5 Pages: 335-347
- DOI
  10.1093/intimm/dxz008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K00562, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-19K07488, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-16H06295
[Journal Article] Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma.2019
- Author(s)
  Goto M, Chamoto K, Higuchi K, Yamashita S, Noda K, Iino T, Miura M, Yamasaki T, Ogawa O, Sonobe M, Date H, Hamanishi J, Mandai M, Tanaka Y, Chikuma S, Hatae R, Muto M, Minamiguchi S, Minato N, Honjo T
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10144-10144
- DOI
  10.1038/s41598-019-46548-3
- NAID
  120006724630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05431, KAKENHI-PROJECT-18H02945, KAKENHI-PROJECT-17K19591, KAKENHI-PROJECT-16H06149
[Journal Article] Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery2019
- Author(s)
  Ito Minako、Komai Kyoko、Mise-Omata Setsuko、Iizuka-Koga Mana、Noguchi Yoshiko、Kondo Taisuke、Sakai Ryota、Matsuo Kazuhiko、Nakayama Takashi、Yoshie Osamu、Nakatsukasa Hiroko、Chikuma Shunsuke、Shichita Takashi、Yoshimura Akihiko
- Journal Title
  
  Nature
  
  Volume: 565 Issue: 7738 Pages: 246-250
- DOI
  10.1038/s41586-018-0824-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15129, KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05514, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H05096, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-17K19571, KAKENHI-PROJECT-17K15667, KAKENHI-PROJECT-17H06175, KAKENHI-PROJECT-20K20384
[Journal Article] Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status.2018
- Author(s)
  Kanamori M, Nakatsukasa H, Ito M, Chikuma S, Yoshimura A.
- Journal Title
  
  Int Immunol.
  
  Volume: 30 Issue: 8 Pages: 357-373
- DOI
  10.1093/intimm/dxy043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15198, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-16J30001, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15667
[Journal Article] Inhibition of Nr4a receptors enhances anti-tumor immunity by breaking Treg-mediated immune tolerance.2018
- Author(s)
  Hibino S, Chikuma S, Kondo T, Ito M, Nakatsukasa H, Omata-Mise S, Yoshimura A
- Journal Title
  
  Cancer Res
  
  Volume: Epub Issue: 11 Pages: 3027-3040
- DOI
  10.1158/0008-5472.can-17-3102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-18K15198, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-20K20384
[Journal Article] Generation and application of human induced-stem cell memory T cells for adoptive immunotherapy.2018
- Author(s)
  Taisuke Kondo Yuki Imura Shunsuke Chikuma Sana Hibino Setsuko Omata‐Mise Makoto Ando Takashi Akanuma Mana Iizuka Ryota Sakai Rimpei Morita Akihiko Yoshimura
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2130-2140
- DOI
  10.1111/cas.13648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15290, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-16K09867, KAKENHI-PROJECT-16K15292, KAKENHI-PROJECT-17K19398, KAKENHI-PROJECT-20K20384, KAKENHI-PROJECT-16H05178
[Journal Article] Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation.2017
- Author(s)
  2)Komai K, Shichita T, Ito M, Kanamori M, Chikuma S, Yoshimura A.
- Journal Title
  
  Int Immunol.
  
  Volume: in press Issue: 2 Pages: 59-70
- DOI
  10.1093/intimm/dxx010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01387, KAKENHI-PROJECT-25221305, KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K19571, KAKENHI-PUBLICLY-17H05514, KAKENHI-PROJECT-17H05096
[Journal Article] Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy.2017
- Author(s)
  Chikuma S, Kanamori M, Mise-Omata S, Yoshimura A.
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 4 Pages: 574-580
- DOI
  10.1111/cas.13194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-16K09867
[Journal Article] Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells.2017
- Author(s)
  Okada M, Chikuma S et al.
- Journal Title
  
  Cell Reports
  
  Volume: 20 Issue: 5 Pages: 1017-1028
- DOI
  10.1016/j.celrep.2017.07.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847, KAKENHI-PROJECT-17K15451, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06501, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H03600, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J07566, KAKENHI-PROJECT-15K19128
[Journal Article] Generation of alloantigen-specific induced-Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model2017
- Author(s)
  Hidenori Kasahara, Taisuke Kondo, Hiroko Nakatsukasa, Shunsuke Chikuma, Minako Ito, Makoto Ando, Yutaka Kurebayashi, Takashi Sekiya, Taketo Yamada, Shinichiro Okamoto, Akihiko Yoshimura
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 10 Pages: 457-469
- DOI
  10.1093/intimm/dxx060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0114, KAKENHI-PUBLICLY-17H05801, KAKENHI-PROJECT-17H07088, KAKENHI-PROJECT-15J03260, KAKENHI-PROJECT-16J07143
[Journal Article] CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation.2017
- Author(s)
  Chikuma S
- Journal Title
  
  Curr Top Microbiol Immunol
  
  Volume: 410 Pages: 99-126
- DOI
  10.1007/82_2017_61
- ISBN
  9783319689289, 9783319689296
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05801
[Journal Article] Basics of PD-1 in self-tolerance, infection, and cancer immunity.2016
- Author(s)
  Shunsuke Chikuma
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: Feb 10
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.2016
- Author(s)
  Zhang B, Chikuma S, Hori S, Fagarasan S, and Honjo T.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 113 Issue: 30 Pages: 8490-8495
- DOI
  10.1073/pnas.1608873113
- NAID
  120005819493
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04747, KAKENHI-PROJECT-16K08847
[Journal Article] Basics of PD-1 in self-tolerance, infection, and cancer immunity.2016
- Author(s)
  Chikuma S
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 21 Issue: 3 Pages: 448-455
- DOI
  10.1007/s10147-016-0958-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08847
[Journal Article] Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22.2015
- Author(s)
  Sakaguchi R, Chikuma S, Shichita T, Morita R, Sekiya T, Ouyang W, Ueda T, Seki H, Morisaki H, Yoshimura A
- Journal Title
  
  Int Immunol.
  
  Volume: Dec 8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] Safety and Anti-tumor Activity of Anti–PD-1 Antibody (Nivolumab: ONO-4538/BMS-936558) in Patients with Platinum-resistant Ovarian Cancer.2015
- Author(s)
  Hamanishi, J., M. Mandai, T. Ikeda, M. Minami, A. Kawaguchi, T. Murayama, M. Kanai, Y. Mori, S. Matsumoto, S. Chikuma, N. Matsumura, K. Abiko, T. Baba, K. Yamaguchi, A. Ueda, Y. Hosoe, S. Morita, M. Yokode, A. Shimizu, T. Honjo, I. Konishi.
- Journal Title
  
  J Clin Oncol
  
  Volume: 33 Issue: 34 Pages: 4015-22
- DOI
  10.1200/jco.2015.62.3397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08230, KAKENHI-PROJECT-26460338, KAKENHI-PROJECT-26253080, KAKENHI-PROJECT-25460363, KAKENHI-PROJECT-25462590, KAKENHI-PROJECT-26861324, KAKENHI-PROJECT-25293069, KAKENHI-PROJECT-26293359, KAKENHI-PROJECT-25500003
[Journal Article] Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models.2014
- Author(s)
  Nguyen T, Xu J, Chikuma S, Hiai H, Kinoshita K, Moriya K, Koike K, Marcuzzi GP, Pfister H, Honjo T, Kobayashi M.
- Journal Title
  
  Int Immunol
  
  Volume: 26 Issue: 7 Pages: 397-406
- DOI
  10.1093/intimm/dxu040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-25460363, KAKENHI-PROJECT-22000015
[Journal Article] Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function2014
- Author(s)
  Stumpf M, Zhou X, Chikuma S, Bluestone JA
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 44 Issue: 6 Pages: 1737-1746
- DOI
  10.1002/eji.201343891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response.2013
- Author(s)
  Rui Y, Honjo T, Chikuma S
- Journal Title
  
  PNAS
  
  Volume: 110 Issue: 40 Pages: 16073-8
- DOI
  10.1073/pnas.1315828110
- NAID
  120005324915
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460363
[Journal Article] A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.2013
- Author(s)
  Taku Okazaki, Shunsuke Chikuma, Yoshiko Iwai, Sidonia Fagarasan, Tasuku Honjo.
- Journal Title
  
  Nat. Immunol.
  
  Volume: 14 Issue: 12 Pages: 1212-1218
- DOI
  10.1038/ni.2762
- NAID
  120005527992
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113516, KAKENHI-PROJECT-24659151, KAKENHI-PROJECT-25293118, KAKENHI-PROJECT-25460363
[Journal Article]2012
- Author(s)
  Chikuma S, Suita N, Okazaki IM, Shibayama S, Honjo T
- Journal Title
  
  Nat. Immunol.
  
  Volume: 13 Issue: 6 Pages: 596-603
- DOI
  10.1038/ni.2293
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article]2012
- Author(s)
  Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y.
- Journal Title
  
  J. Exp. Med
  
  Volume: 209 Pages: 1743-52
- URL
  http://jem.rupress.org/content/209/10/1743.long
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article] (*Equal contribution) IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity2011
- Author(s)
  Terawaki S, Chikuma S, Shibayama S, et al
- Journal Title
  
  J Immunol Vol.186
  
  Pages: 2772-2779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790465
[Journal Article] IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.2011
- Author(s)
  Terawaki S, Chikuma S, Shibayama S, et al.(Equal contribution)
- Journal Title
  
  The Journal of Immunology
  
  Volume: 186 Pages: 2772-2779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790465
[Journal Article] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age.2011
- Author(s)
  Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong le T, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article]2011
- Author(s)
  Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong LT, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
- Journal Title
  
  Plos One
  
  Volume: 6
- URL
  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029141
- Data Source
  KAKENHI-PROJECT-23790534
[Journal Article] The expression of differentiation markers in aquaporin deficient epidermis2009
- Author(s)
  Hara-Chikuma M, Takahashi K, Chikuma S, Verkman AS, and Miyachi Y
- Journal Title
  
  Arch. Dermatol. Res. vol.301
  
  Pages: 245-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Honjo T PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo2009
- Author(s)
  Chikuma S, Terawaki S, Hayashi T, Nabeshima R, Yoshida T, Shibayama S, Okazaki T
- Journal Title
  
  J.Immunol Vol.182
  
  Pages: 6682-6689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790465
[Journal Article] PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo2009
- Author(s)
  Chikuma S, Terawaki S, Hayashi T, Nabeshima R, Yoshida T, Shibayama S, Okazaki T, Honjo T
- Journal Title
  
  J. Immunol. vol.182
  
  Pages: 6682-6689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] PD-1-mediated suppression of IL-2 production induces CD8+T cell anergy in vivo2009
- Author(s)
  Chikuma S., et.al.
- Journal Title
  
  The Journal of Immunology 182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Identification of QTLs that modify peripheral neuropathy in NOD. H2b-Pdcd1-/- mice2009
- Author(s)
  Jiang F, Yoshida T, Nakaki F, Terawaki S, Chikuma S, Kato Y, Okazaki IM, Honjo T, Okazaki T
- Journal Title
  
  Int. Immunol. vol.21
  
  Pages: 499-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Identification of QTLs that modify peripheral neuropathy in NOD. H2b-Pdcd1-/- mice2009
- Author(s)
  Jiang, Yoshida, Nakaki, Terawaki, Chikuma S, et.al.
- Journal Title
  
  International Immunology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.2007
- Author(s)
  Chikuma S and Bluestone JA
- Journal Title
  
  The European Journal of Immunology 37
  
  Pages: 1285-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Journal Article] Expression of CTLA-4 and FoxP3 in cis protects from lethal lymphoproliferative disease2007
- Author(s)
  Chikuma S, Bluestone J
- Journal Title
  
  Eur. J. Immunol. vol.37
  
  Pages: 1285-1289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] Loss of TRIM28 Function on Immune Cells Recapitulate Immune aging2024
- Author(s)
  Shunsuke Chikuma
- Organizer
  日中韓フォーサイトキックオフ
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] 体内で長期間生存する「しつこい」Ｔ細胞を除去する方法2024
- Author(s)
  竹馬　俊介
- Organizer
  2023年度文部科学省学術変革領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] Mechanisms of immunotolerance and immune-aging mediated by an epigenomic factor2023
- Author(s)
  Shunsuke Chikuma
- Organizer
  国立清華大学生命科学院セミナーシリーズ
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] アバタセプト抵抗性「しつこい」メモリーＴ細胞を、アルデヒド脱水素酵素阻害剤で退治する2023
- Author(s)
  竹馬　俊介
- Organizer
  第32回京都T細胞会議
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] Mechanisms of T cell tolerance and prevention of immune-aging by epigenomic Trim282023
- Author(s)
  Shunsuke Chikuma
- Organizer
  中国医薬大学癌生物研究センター特別セミナー
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] CD28シグナルを必要としない「しつこい」メモリーＴ細胞を除去する方法2023
- Author(s)
  竹馬　俊介
- Organizer
  自己指向性免疫学若手ワークショップ
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] ポドサイトDNA損傷は血球細胞DNAメチル化変化を惹起しmemoryＴ細胞による腎機能増悪を誘導する2022
- Author(s)
  中道蘭, 林香, 竹馬俊介, 菱川彰人, 吉本憲史, 杉田絵里那, 伊藤裕
- Organizer
  第65回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] 内在性レトロウイルス抑制機構を標的とした免疫治療法を目指す2022
- Author(s)
  竹馬　俊介
- Organizer
  第19回日本免疫治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] 内在性レトロウイルス抑制機構を標的とした免疫治療法を目指す2022
- Author(s)
  竹馬　俊介
- Organizer
  第19回日本免疫治療学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] A PKD inhibitor Suppresses AKT on T cells and Antagonizes Cancer Immunotherapy by anti-PD-12022
- Author(s)
  Shunsuke Chikuma
- Organizer
  第81回日本癌学会学術集会　横浜市　2022年9月29日～10月1日
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2022
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　成果発表会
- Data Source
  KAKENHI-PROJECT-19K07488
[Presentation] A PKD inhibitor cancels the effect of PD-1 blockade in a murine model of cancer immunotherapy.2022
- Author(s)
  Shunsuke Chikuma
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] Immune Aging Associates with a Progressive Loss of Chromatin Regulatory Factor TRIM28 on Immune Cells2022
- Author(s)
  Shunsuke Chikuma
- Organizer
  23rd Northeastern Asian Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Presentation] TRIM28 mediated Treg function underlies suppressive tumor immune environment.2022
- Author(s)
  Hodaka Hayabuchi, Shunsuke Chikuma
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] A PKD inhibitor cancels the effect of PD-1 blockade in a murine model of cancer immunotherapy2022
- Author(s)
  Shunsuke Chikuma
- Organizer
  第81回日本癌学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] 内在性レトロウイルス抑制機構を標的とした免疫治療法を目指す2022
- Author(s)
  竹馬　俊介
- Organizer
  第19回日本免疫治療学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Presentation] Immune Aging Associates with a Progressive Loss of Chromatin Regulatory Factor TRIM28 on Immune Cells2022
- Author(s)
  Shunsuke Chikuma
- Organizer
  23rd Northeastern Asian Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] Ｔ細胞寛容におけるクロマチン制御因子TRIM28の機能解析2022
- Author(s)
  竹馬　俊介
- Organizer
  京都Ｔ細胞会議
- Invited
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] A PKD inhibitor cancels the effect of PD-1 blockade in a murine model of cancer immunotherapy2022
- Author(s)
  Shunsuke Chikuma
- Organizer
  第51回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2022
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　成果発表会
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Presentation] TRIM28 mediated Treg function underlies suppressive tumor immune environment2022
- Author(s)
  Hodaka Hayabuchi and Shunsuke Chikuma
- Organizer
  第51回日本免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24114
[Presentation] A progressive loss of TRIM28 causes immune-aging2022
- Author(s)
  Shunsuke Chikuma
- Organizer
  Northeastern Asian symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19446
[Presentation] T細胞寛容におけるクロマチン制御因子TRIM28の機能解析2021
- Author(s)
  竹馬　俊介
- Organizer
  第29回京都T細胞会議
- Data Source
  KAKENHI-PROJECT-19K07488
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2021
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　特別プログラム講演
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05431
[Presentation] エピゲノム因子による、自己免疫寛容、がん免疫寛容の調節2021
- Author(s)
  竹馬　俊介
- Organizer
  文科省先端モデル動物支援プラットフォーム　特別プログラム講演
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H04816
[Presentation] T細胞寛容におけるクロマチン制御因子TRIM28の機能解析2021
- Author(s)
  竹馬　俊介
- Organizer
  第29回京都T細胞会議
- Data Source
  KAKENHI-PUBLICLY-21H00439
[Presentation] Singularity in Immunity: Immune-aging associates with a defect in Chromatin Regulation on Immune Cells.2020
- Author(s)
  Chikuma S
- Organizer
  日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05431
[Presentation] Pathogenesis of autoreactive Th17 cells is driven by homeostatic cytokines stimulated by commensal microbiota2017
- Author(s)
  Chikuma et al.
- Organizer
  The 5th annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08847
[Presentation] PD-1 inhibits inflammatory helper T-cell development through controlling the innate immune response2013
- Author(s)
  Rui Y, Honjo T, Chikuma S
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-25460363
[Presentation] 抗 PD-1 抗体によるがん治療法2012
- Author(s)
  竹馬俊介
- Organizer
  日台癌のトランスレーショナル研究シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] 北海道大学獣医学部学術交流資金群講演会2012
- Author(s)
  竹馬俊介
- Organizer
  自己免疫疾患研究の最先端
- Place of Presentation
  札幌
- Year and Date
  2012-11-01
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] T cell-expression of Trim28 prevents development of auto-inflammatory T cells2011
- Author(s)
  Shunsuke Chikuma
- Organizer
  2nd CSI/JSI/KAI Joint Symposium on Immunology（日中韓免疫シンポジウム）(招待講演)
- Place of Presentation
  Osaka University（大阪府）
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] Type I interferon promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity2011
- Author(s)
  Shunsuke Chikuma
- Organizer
  98th Annual Meeting, The American Association of Immunologists
- Place of Presentation
  San Francisco, U.S.A.
- Data Source
  KAKENHI-PROJECT-21790465
[Presentation] In search of molecules that regulate PD-1 mediated inhibition of T cell function2010
- Author(s)
  Shunsuke Chikuma
- Organizer
  14th International congress of Immunology
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-21790465
[Presentation] In search of molecules that regulate PD-1 mediated inhibition of T cell function.2010
- Author(s)
  Shunsuke Chikuma
- Organizer
  14^<th> International congress of Immunology Aug 23-27, 2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790465
[Presentation] PD-1 induces T cell anergy by limiting autonomous IL-2 production2008
- Author(s)
  Chikuma S, Terawaki S, Okazaki T, Honjo T
- Organizer
  第38回日本免疫学会総会・学術集会, Vol.38, p.234
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] マウスPD-1の転写機構/Transcriptional Mechanisms of Mouse PD-1 Gene2008
- Author(s)
  Terawaki S, Chikuma S, et.al.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] PD-1 induces T cellanergy by limiting autonomous IL-2 production2008
- Author(s)
  Chikuma S., et.al.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] Transcriptional mechanisms of mouse PD-1 gene2008
- Author(s)
  Terawaki S, Chikuma S, Okazaki T, Honjo T
- Organizer
  第38回日本免疫学会総会・学術集会, Vol.38, p.234
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790356
[Presentation] 抗PD-1抗体によるがん治療法
- Author(s)
  竹馬　俊介
- Organizer
  日台癌のトランスレーショナル研究シンポジウム
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23790534
[Presentation] Analysis of PD-1 expression and function on innate immune cells
- Author(s)
  Chikuma S, Honjo T
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25460363
[Presentation] 核内因子TRIM28による自己炎症性T細胞の制御
- Author(s)
  竹馬　俊介
- Organizer
  北海道大学獣医学部　学術交流資金群講演会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-23790534

1. MIYACHI Hitoshi (90599200)

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# of Collaborated Products: 1 results
17. 駒井恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡崎拓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 伊藤裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chikuma Shunsuke 竹馬 俊介

CHIKUMA Shunsuke 竹馬 俊介

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肝内Ｔ細胞の自己認識による「功」の解明Principal Investigator

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In vivo deletion of abatacept-resistant persistent autoreactive memory T cellsPrincipal Investigator

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内在性レトロウイルス抑制因子による、がん免疫寛容機構の基盤研究Principal Investigator

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自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator

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Mechanisms of long-term survival of self-reactive helper T cellsPrincipal Investigator

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クロマチン抑制因子の破綻によるネオセルフ生成Principal Investigator

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自己免疫疾患の発症・非発症を規定する特異点の検出Principal Investigator

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遺伝子サイレンシング機構の破綻によるネオセルフ生成と、免疫活性化の検証Principal Investigator

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Regulation of self-reactive T cells by TRIM28Principal Investigator

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The mechanism of strong PD-1 expression leading to immuno-suppression.Principal Investigator

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PD-1 and novel immune-regulatory molecules in T cell differentiation.Principal Investigator

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A novel molecule that regulates T-cell tolerance under PD-1.Principal Investigator

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Mechanistic basis for induction of T-cell anergy by PD-1, an immuno-regulatory receptorPrincipal Investigator

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Chikuma Shunsuke 竹馬俊介

CHIKUMA Shunsuke 竹馬俊介