Terai Hideki 寺井秀樹

… Alternative Names

寺井秀樹テライヒデキ

TERAI HIDEKI 寺井秀樹

TERAI Hideki 寺井秀樹

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Researcher Number	50445293
Other IDs	https://orcid.org/0000-0002-1118-1930
Affiliation (Current)	2024: 慶應義塾大学, 医学部(信濃町), 講師 2024: 北里大学, 北里研究所病院, 医師
Affiliation (based on the past Project Information) *help	2022: 慶應義塾大学, 医学部(信濃町), 講師 2019 – 2020: 慶應義塾大学, 医学部(信濃町), 特任助教 2018: 北里大学, 北里研究所病院, 医長 2014: 慶應義塾大学, 医学部, 共同研究員 2012 – 2013: 慶應義塾大学, 医学部, 助教 2011 – 2012: 慶應義塾大学, 医学部, 特任助教 2010: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator EGFR-TKI / DNAメチル化 / ICI / 肺扁平上皮癌 / STING / drug resistance / CRISPR screening / 非小細胞肺癌 / drug persister / celastrol … More / lung cancer / EGFR / MAPK / SHOC2 / CRISPR/Cas9 / epigenetics / エピジェネティクス / EGFR-TKI耐性化 / FGFR / FGFR1 / FGF2 / 獲得耐性 / ゲフィチニブ / イレッサ / 薬剤耐性 / 肺癌 … More Except Principal Investigator PI3K / pathway signature / 染色体転座 / Exon array / 扁平上皮癌 / 腺癌 / FGF / 融合遺伝子 / exon array / microRNA / fibroblast growth factor-9 / pathway signature解析 / 網羅的解析 / 非小細胞肺癌 Less

Discovery of novel cancer treatment through elucidation of cGAS/STING pathway in lung squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  寺井秀樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
Discovery of novel cancer treatment with CRIPR/Cas9 screeningPrincipal Investigator
- Principal Investigator
  
  TERAI HIDEKI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
  Kitasato University
網羅的遺伝子解析手法を用いたゲフィチニブ耐性化機序の解明Principal Investigator
- Principal Investigator
  
  寺井秀樹
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Investigation of the mechanism of gefitinib resistance by comprehensive genetic analysisPrincipal Investigator
- Principal Investigator
  
  TERAI Hideki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Screening of fusion genes in non-small cell lung cancer
- Principal Investigator
  
  SOEJIMA Kenzo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University

All 2021 2020 2019 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Functional dissection of the KRAS G12C mutation by comparison among multiple oncogenic driver mutations in a lung cancer cell line model2021
- Author(s)
  Kobayashi Keigo、Terai Hideki、Yasuda Hiroyuki、Hamamoto Junko、Hayashi Yuichiro、Takeuchi Osamu、Mitsuishi Yoichiro、Masuzawa Keita、Manabe Tadashi、Ikemura Shinnosuke、Kawada Ichiro、Suzuki Yukio、Soejima Kenzo、Fukunaga Koichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 534 Pages: 1-7
- DOI
  10.1016/j.bbrc.2020.11.110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells2020
- Author(s)
  Ohgino Keiko、Terai Hideki、Yasuda Hiroyuki、Nukaga Shigenari、Hamamoto Junko、Tani Tetsuo、Kuroda Aoi、Arai Daisuke、Ishioka Kota、Masuzawa Keita、Ikemura Shinnosuke、Kawada Ichiro、Naoki Katsuhiko、Fukunaga Koichi、Soejima Kenzo
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 10 Pages: 3793-3801
- DOI
  10.1111/cas.14569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer2020
- Author(s)
  Manabe Tadashi、Yasuda Hiroyuki、Terai Hideki、Kagiwada Harumi、Hamamoto Junko、Ebisudani Toshiki、Kobayashi Keigo、Masuzawa Keita、Ikemura Shinnosuke、Kawada Ichiro、Hayashi Yuichiro、Fukui Kazuhiko、Horimoto Katsuhisa、Fukunaga Koichi、Soejima Kenzo
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 印刷中 Issue: 4 Pages: 549-559
- DOI
  10.1158/1541-7786.mcr-19-0956
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-19J12401, KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18K15959, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells2020
- Author(s)
  Terai Hideki、Hamamoto Junko、Emoto Katsura、Masuda Takeshi、Manabe Tadashi、Kuronuma Satoshi、Kobayashi Keigo、Masuzawa Keita、Ikemura Shinnosuke、Nakayama Sohei、Kawada Ichiro、Suzuki Yusuke、Takeuchi Osamu、Suzuki Yukio、Ohtsuki Sumio、Yasuda Hiroyuki、Soejima Kenzo、Fukunaga Koichi
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 19 Issue: 2 Pages: 317-328
- DOI
  10.1158/1541-7786.mcr-20-0664
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05544, KAKENHI-PROJECT-20K17190, KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18K08184
[Journal Article] Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab.2019
- Author(s)
  Oashi A, Yasuda H, Kobayashi K, Tani T, Hamamoto J, Masuzawa K, Manabe T, Terai H, Ikemura S, Kawada I, Naoki K, Soejima K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 18 Issue: 9 Pages: 1593-1601
- DOI
  10.1158/1535-7163.mct-18-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03671, KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18K08184
[Journal Article] Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations2019
- Author(s)
  Hasegawa H, Yasuda H, Hamamoto J, Masuzawa K, Tani T, Nukaga S, Hirano T, Kobayashi K, Manabe T, Terai H, Ikemura S, Kawada I, Naoki K, Soejima K.
- Journal Title
  
  Lung Cancer
  
  Volume: 127 Pages: 146-52
- DOI
  10.1016/j.lungcan.2018.11.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-18J12516, KAKENHI-PROJECT-18K08184
[Journal Article] Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC Cells.2013
- Author(s)
  Terai H, Soejima K, Yasuda H, et al
- Journal Title
  
  Mol Cancer Res
  
  Volume: 印刷中 Issue: 7 Pages: 759-767
- DOI
  10.1158/1541-7786.mcr-12-0652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590870, KAKENHI-PROJECT-23501311, KAKENHI-PROJECT-24790822
[Journal Article] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma2013
- Author(s)
  Hamamoto J, Soejima K, Yoda S, Naoki K, Nakayama S, Satomi R, Terai H, Ikemura S, Sato T, Yasuda H, Hayashi Y, Sakamoto M, Takebayashi T, Betsuyaku T
- Journal Title
  
  Mol Med Rep
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590870
[Journal Article] Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC Cells.2013
- Author(s)
  Terai H, Soejima KN, Yasuda H, Nakayama S, Hamamoto J, Arai D, Ishioka K, Ohgino K, Ikemura S, Sato T, Yoda S, Satomi R, Naoki K, Betsuyaku T.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790822
[Journal Article] The PCR-Invader method (structure-specific 5' nuclease based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens ; comparison with direct sequencing2011
- Author(s)
  Naoki K, Soejima K, Okamoto H, Hamamoto J, Hida N, Nakachi I, Yasuda H, Nakayama S, Yoda S, Satomi R, Ikemura S, Terai H, Sato T, Watanabe K
- Journal Title
  
  Int J ClinOncol
  
  Volume: 16 Pages: 335-344
- NAID
  10029527544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] EGFRチロシンキナーゼ阻害剤の初期耐性におけるSHOC2の役割2019
- Author(s)
  浜本純子、寺井秀樹、眞鍋維志、小林慧悟、増澤啓太、安田浩之、川田一郎、副島研造
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08184
[Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure2013
- Author(s)
  Terai H, Soejima K, Naoki K, Yasuda H, Satomi R, Nakayama S, Yoda S, Ikemura S, Sato T, Ishioka K, Arai D, Ohgino K, Hamamoto J, Betsuyaku T
- Organizer
  American Association for Cancer Research
- Place of Presentation
  ワシントン（アメリカ）
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Kenzo Soejima, Katsuhiko Naoki et al. Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure2013
- Author(s)
  Hideki Terai
- Organizer
  103th AACR annual meeting
- Place of Presentation
  Washington, DC.
- Data Source
  KAKENHI-PROJECT-24790822
[Presentation] FGF9 overexpression promotes tumorigenic potential of non-small cell lung cancer (NSCLC) cells and is associated with poor prognosis in NSCLC2013
- Author(s)
  Ishioka K, Soejima K, Yasuda H, Ohgino K, Arai D, Kuroda A, Tani T, Sato T, Terai H, Ikemura S, Yoda S, Hamamoto J, Naoki K, Betsuyaku T
- Organizer
  American Association for Cancer Research
- Place of Presentation
  ワシントン（アメリカ）
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2013
- Author(s)
  H. Terai, K. Soejima, K. Naoki, H. Yasuda, R. Satomi, S. Nakayama, S.Yoda, S. Ikemura, T. Sato, K. Ishioka, D. Arai, K. Ohgino, J. Hamamoto, T. Betsuyaku
- Organizer
  2013 AACR annual meeting
- Place of Presentation
  Washington, DC, USA
- Data Source
  KAKENHI-PROJECT-24790822
[Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2013
- Author(s)
  H. Terai, K. Soejima, K. Naoki, et al.
- Organizer
  103th AACR Annual Meeting
- Place of Presentation
  Washington, DC.
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] 肺癌におけるTFPI-2のメチル化によるTMPRSS4の過剰発現と癌化2012
- Author(s)
  浜本純子，副島研造，安田浩之，荒井大輔，石岡宏太，池村辰之介，寺井秀樹，猶木克彦，別役智子
- Organizer
  日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] FGF9 (fibroblast growth factor 9) 発現肺癌における臨床および遺伝子発現に関する検討2012
- Author(s)
  120. 扇野圭子，副島研造，荒井大輔，石岡宏太，池村辰之介，寺井秀樹，浜本純子，猶木克彦，別役智子
- Organizer
  日本臨床腫瘍学会総会
- Place of Presentation
  大阪国際会議場（大阪府）
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Kenzo Soejima, Katsuhiko Naoki, etal. Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2012
- Author(s)
  Hideki Terai
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790822
[Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.2012
- Author(s)
  寺井秀樹、副島研造、猶木克彦、安田浩之、池村辰之介、佐藤崇、荒井大輔、石岡宏太、扇野圭子、濱本純子、別役智子
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌・ホテルロイトン札幌
- Data Source
  KAKENHI-PROJECT-24790822
[Presentation] 肺癌患者における気道上皮被覆液のプロテオーム解析2011
- Author(s)
  寺井秀樹、副島研造、渡辺真純、猶木克彦、安田浩之、里見良輔、中山荘平、依田聡、池村辰之介、佐藤崇、諸澤麻衣子、浅野浩一郎
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Analysis of aberrant DNA methylation and expression of corresponding mRNA in EGFR-TKI-sensitive lung cancer cell line with long-term gefitinib exposure.2011
- Author(s)
  H. Terai, K. Soejima, K. Naoki, et al.
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] 肺癌患者の気道上皮被覆液を用いたプロテオーム解析.2011
- Author(s)
  寺井秀樹, 副島研造, 渡辺真純
- Organizer
  第34回日本呼吸器内視鏡学会総会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Analysis of aberrant DNA methylation and expression of corre sponding mRNA in EGFR-TKI-sensitive lung cancer cell line with long-term gefitinib exposure2011
- Author(s)
  H.Terai, K Soejima, K.Naoki, R.Satomi, S.Nakayama, S.Yoda, S.Ikemura, T.Sato, J.Hamamoto, K.Asano, T.Betsuyaku
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Expression of fibroblast growth factor-9 is associated with poor prognosis of resected non-small cell lung cancer patients2011
- Author(s)
  Ohgino K, Soejima K, Arai D, Ishioka K, Terai H, Ikemura S, Sato T, Yoda S, Hamamoto J, Naoki K, Betsuyaku T
- Organizer
  American Association for Cancer Resereach
- Place of Presentation
  米国、シカゴ
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma.2011
- Author(s)
  Junko Hamamoto, Hideki Terai, Katsuhiko Naoki, Takashi Sato, Kenzo Soejima.
- Organizer
  American Association for Cancer Resereach
- Place of Presentation
  米国、オーランド
- Year and Date
  2011-04-06
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma2011
- Author(s)
  Hamamoto J, Yoda S, Naoki K, Nakayama S, Satomi R, Terai H, Ikemura S, SatoT, Izumi Y, Kawamura M, Nomori H, Hayashi Y, Sakamoto M, Takebayashi T, Soejima K
- Organizer
  American Association for Cancer Resereach
- Place of Presentation
  米国、オーランド
- Year and Date
  2011-04-06
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] 肺癌患者における気道上皮被覆液のプロテオーム解析.2011
- Author(s)
  寺井秀樹、副島研造、渡辺真純
- Organizer
  第51回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590870
[Presentation] Activation of FGF2-FGFR1 pathway in EGFR-mutant lung cancer cell line with long-term gefitinib exposure.
- Author(s)
  Hideki Terai
- Organizer
  2013 104th AACR Annual Meeting
- Place of Presentation
  Washington D. C. Convention Center
- Data Source
  KAKENHI-PROJECT-24790822
[Presentation] Aberrant DNA methylation and expression of mRNA in EGFR-mutant lung cancer cell line with long-term exposure to gefitinib
- Author(s)
  Hideki Terai
- Organizer
  104th AACR Annual Meeting
- Place of Presentation
  San Diego
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-26860616
[Presentation] Aberrant DNA methylation and expression of mRNA in EGFR-mutant lung cancer cell line with long-term exposure to gefitinib
- Author(s)
  Hideki Terai
- Organizer
  2014 105th AACR Annual Meeting
- Place of Presentation
  San Diego Convention Center
- Data Source
  KAKENHI-PROJECT-24790822

1. SOEJIMA Kenzo (30236145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
2. HAMAMOTO Junko (40570239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. NAOKI Katsuhiko (40265806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
4. SATO Takashi (20464836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
5. KAWAMURA Masafumi (70169770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. MASUDA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 増澤啓太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 安田浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Terai Hideki 寺井 秀樹

寺井 秀樹 テライ ヒデキ

TERAI HIDEKI 寺井 秀樹

TERAI Hideki 寺井 秀樹

Research Projects

Research Products

Co-Researchers

Discovery of novel cancer treatment through elucidation of cGAS/STING pathway in lung squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of novel cancer treatment with CRIPR/Cas9 screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

網羅的遺伝子解析手法を用いたゲフィチニブ耐性化機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism of gefitinib resistance by comprehensive genetic analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of fusion genes in non-small cell lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Functional dissection of the KRAS G12C mutation by comparison among multiple oncogenic driver mutations in a lung cancer cell line model2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intracellular levels of reactive oxygen species correlate with ABT‐263 sensitivity in non‐small‐cell lung cancer cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monomer Preference of EGFR Tyrosine Kinase Inhibitors Influences the Synergistic Efficacy of Combination Therapy with Cetuximab.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC Cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma2013

Author(s)

Journal Title

Data Source

[Journal Article] Activation of the FGF2-FGFR1 Autocrine Pathway: A Novel Mechanism of Acquired Resistance to Gefitinib in NSCLC Cells.2013

Author(s)

Journal Title

Data Source

Terai Hideki 寺井秀樹

寺井秀樹テライヒデキ

TERAI HIDEKI 寺井秀樹

TERAI Hideki 寺井秀樹