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Hasegawa Takahiro  長谷川 敬展

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HASEGAWA Takahiro  長谷川 敬展

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Researcher Number 50447273
Other IDs
Affiliation (Current) 2022: 徳島大学, 大学院医歯薬学研究部(歯学域), 講師
Affiliation (based on the past Project Information) *help 2015: 徳島大学, 大学院医歯薬学研究部, 助教
2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 助教
2013: 徳島大学, 大学院ヘルスバイオサイエンス 研究部(歯学系), 助教
2007 – 2012: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教
Review Section/Research Field
Principal Investigator
Functional basic dentistry / Animal physiology/Animal behavior
Except Principal Investigator
Functional basic dentistry
Keywords
Principal Investigator
リン酸化 / アクアポリン / 翻訳後修飾 / ユビキチン化 / 細胞内膜輸送 / 唾液腺 / アクアポリン5 / アクアポリン2 / 腎臓集合管 / 小胞輸送 … More / プルダウンアッセイ / 結合タンパク質 / アクアポリン5(AQP5) / 細胞内輸送 / 口腔生理学 / 細胞内シグナル伝達 … More
Except Principal Investigator
唾液腺 / アクアポリン / カテプシン / 副交感神経 / 塩酸セビメリン / MDCK細胞 / トラフィッキング / GFP-AQP5キメラ分子 / アクアポリン5 / LPS / 遺伝子変異 / 鼓索神経切除 / 顎下腺 / 腺房細胞 / 発生・分化・再生 / サチライシン様前駆体蛋白質変換酵素 / PACE4 / 水チャネル / AQP5 / bHLH型転写因子 / HSG細胞 Less
  • Research Projects

    (7 results)
  • Research Products

    (25 results)
  • Co-Researchers

    (11 People)
  •  Molecular regulatory mechanisms for post-translational modifications of the water channel controlling salivary secretion.Principal Investigator

    • Principal Investigator
      HASEGAWA Takahiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  病態時における外分泌腺型水チャネル、AQP5の発現と機能調節の分子機構

    • Principal Investigator
      細井 和雄
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Elucidation of the molecular mechanism on the differentiation/maturation and functional expression of salivary acinar cell toward conquest of xerostomia.

    • Principal Investigator
      AKAMATSU Tetsuya
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Physiological roles ofpost-translational modifications of water channel aquaporin-5 in the salivary glands.Principal Investigator

    • Principal Investigator
      HASEGAWA Takahiro
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Regulation of posttranslational modification of water channel aquaporin-5 in the intracellular localization and traffickingPrincipal Investigator

    • Principal Investigator
      HASEGAWA Takahiro
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima
  •  Gontrol of intracellular trafficking of water channel aquaporin-2Principal Investigator

    • Principal Investigator
      HASEGAWA Takahiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Animal physiology/Animal behavior
    • Research Institution
      The University of Tokushima
  •  Moecular meohanism of expression and regulation of the water channe1, aquapor in 5 in the exocrine gland

    • Principal Investigator
      HOSOI Kazuo
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The University of Tokushima

All 2013 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013

    • Author(s)
      赤松徹也,姚陳娟,長谷川敬展,吉村弘
    • Journal Title

      J. Oral Biosci.

      Volume: Suppl. Pages: 199-199

    • Data Source
      KAKENHI-PROJECT-23592737
  • [Journal Article] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013

    • Author(s)
      赤松徹也,姚陳娟,長谷川敬展,吉村弘
    • Journal Title

      J. Oral Biosci

      Volume: Suppl Pages: 199-199

    • Data Source
      KAKENHI-PROJECT-23592737
  • [Journal Article] Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats2011

    • Author(s)
      Karabasil MR, Hasegawa T, Hosoi K (他5名, 2番目)
    • Journal Title

      Biol Cell 103

      Pages: 69-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791806
  • [Journal Article] Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling.2011

    • Author(s)
      Hasegawa T, et al
    • Journal Title

      American journal of physiology. Cell physiology

      Volume: 301(3)

    • DOI

      10.1152/ajpcell.00058.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592736, KAKENHI-PROJECT-23792124
  • [Journal Article] Localization of water channels in the skin of two species of desert toads, Anaxyrus (Bufo) punctatus andIncilius (Bufo) alvarius2011

    • Author(s)
      Shibata Y, Takeuchi HA, Hasegawa T, Suzuki M, Tanaka S, Hillyard SD, Nagai T
    • Journal Title

      Zoological Science

      Volume: 28 Issue: 9 Pages: 664-670

    • DOI

      10.2108/zsj.28.664

    • NAID

      40018988020

    • ISSN
      0289-0003
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570075, KAKENHI-PROJECT-23792124
  • [Journal Article] Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kB and p-c-Jun/c-Fos.2010

    • Author(s)
      Yao C, Hasegawa T, Hosoi K.(他7名, 6 番目)
    • Journal Title

      Am J Pathol 177

      Pages: 724-734

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791806
  • [Journal Article] Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation2010

    • Author(s)
      Azlina A, Hasegawa T, Hosoi K.(他4名, 4番目)
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791806
  • [Journal Article] Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif ((152)SRRTS) in MDCK-II cells.2009

    • Author(s)
      Karabasil MR, Hasegawa T, Azlina A, Purwanti N, Purevjav J, Yao C, Akamatsu T, Hosoi K.
    • Journal Title

      J Med Invest 56

      Pages: 55-63

    • NAID

      130004465167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19770054
  • [Journal Article] Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland2009

    • Author(s)
      Akamatsu T, Azlina A, Purwanti N, Karabasil MR, Hasegawa T, Yao C, Hosoi K
    • Journal Title

      Dev Biol 325

      Pages: 434-443

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19770054
  • [Journal Article] Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif(152SRRTS) in MDCK-II cells2009

    • Author(s)
      Karabasil, M.R., T. Hasegawa, A. Azlina, N. Purwanti, J.Purevjav, C. Yao, T. Akamatsu and K. Hosoi
    • Journal Title

      The Journal of Medical Investigation 56(1, 2)

      Pages: 55-63

    • NAID

      130004465167

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland2009

    • Author(s)
      Akamatsu, T., A. Azlina, N. Purwanti, M.R. Karabasil, T. Hasegawa, C. Yao, and K. Hosoi
    • Journal Title

      Developmental Biology 325(2)

      Pages: 434-443

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] Localization and trafficking of aquaporin 2 in the kidney2008

    • Author(s)
      Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
    • Journal Title

      Histochem Cell Biol 130

      Pages: 197-209

    • Data Source
      KAKENHI-PROJECT-19770054
  • [Journal Article] Degradation of submandibular gland AQP5 by parasympathetic denervation of chords tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist2008

    • Author(s)
      Li X., A. Azlina, M.R. Karabasil, N. Purwanti, T. Hasegawa, C. Yao, T. Akamatsu, and K. Hosoi
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology 295(1)

      Pages: 112-123

    • Data Source
      KAKENHI-PROJECT-18390493
  • [Journal Article] Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist2008

    • Author(s)
      LiX, Azlina A, Karabasil MR, Purwanti N, Hasegawa T, Yao C, Akamatsu T, Hosoi K
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 295

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19770054
  • [Presentation] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013

    • Author(s)
      赤松徹也,姚陳娟,長谷川敬展,吉村弘
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Data Source
      KAKENHI-PROJECT-23592737
  • [Presentation] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013

    • Author(s)
      赤松徹也,姚陳娟,長谷川敬展,吉村弘
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      (岡山コンベンションセンター/岡山県)
    • Data Source
      KAKENHI-PROJECT-23592737
  • [Presentation] 唾液腺細胞におけるアクアポリン5の翻訳後修飾2011

    • Author(s)
      長谷川敬展
    • Organizer
      第53回歯科基礎医学会学術大会・総会サテライトシンポジウム
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Data Source
      KAKENHI-PROJECT-23792124
  • [Presentation] 唾液腺細胞におけるアクアポリン5の翻訳後修飾2011

    • Author(s)
      長谷川敬展
    • Organizer
      第53回歯科基礎医学会サテライトシンポジウム11「唾液腺談話会」
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-09-30
    • Data Source
      KAKENHI-PROJECT-23592736
  • [Presentation] 唾液腺細胞におけるアクアポリン 5 の翻訳後修2011

    • Author(s)
      長谷川敬展
    • Organizer
      第53回歯科基礎医学会学術大会・総会サテライトシンポジウム
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2011-09-30
    • Data Source
      KAKENHI-PROJECT-23792124
  • [Presentation] 唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構2010

    • Author(s)
      長谷川敬展
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-21
    • Data Source
      KAKENHI-PROJECT-21791806
  • [Presentation] 唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構2010

    • Author(s)
      長谷川敬展、アズリナアハマド、ジャフランフルジャフ、廣島佑香、姚陳娟、赤松徹也、細井和雄
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-21791806
  • [Presentation] アクアポリン5のユビキチン化とその細胞内輸送系における役割2009

    • Author(s)
      長谷川敬展
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Year and Date
      2009-09-10
    • Data Source
      KAKENHI-PROJECT-21791806
  • [Presentation] アクアポリン5のユビキチン化とその細胞内輸送系における役割2009

    • Author(s)
      長谷川敬展、アズリナアハマド、ジャフランフルジャフ、姚陳娟、赤松徹也、細井和雄
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟市
    • Data Source
      KAKENHI-PROJECT-21791806
  • [Presentation] ヒト唾液腺HSG細胞における構成的なAQP5 の取り込み

    • Author(s)
      長谷川敬展、姚陳娟、赤松徹也、吉村弘
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山県岡山市(岡山コンベンションセンター)
    • Data Source
      KAKENHI-PROJECT-25462891
  • [Presentation] ユビキチンリガーゼによるAQP5のユビキチン化亢進とダウンレギュレーション

    • Author(s)
      長谷川敬展、姚陳娟、赤松徹也、吉村弘
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡県福岡市(福岡国際会議場)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25462891
  • 1.  HOSOI Kazuo (10049413)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 2.  AKAMATSU Tetsuya (80294700)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 3.  YAO Chenjuan (20432750)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 4.  KANAMORI Norio (90064865)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIMURA Hiroshi (90288845)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  李 雪飛
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NUNUK Purwanti
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MILEVA Ratko Karabasil
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  AZLINA Ahmad
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  JAVKHLAN Purevjav
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  鈴木 雅一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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