Hasegawa Takahiro 長谷川敬展

… Alternative Names

HASEGAWA Takahiro 長谷川敬展

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Researcher Number	50447273
Other IDs
Affiliation (Current)	2023: 徳島大学, 大学院医歯薬学研究部(歯学域), 講師
Affiliation (based on the past Project Information) *help	2015: 徳島大学, 大学院医歯薬学研究部, 助教 2011 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 助教 2013: 徳島大学, 大学院ヘルスバイオサイエンス研究部(歯学系), 助教 2007 – 2012: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教
Review Section/Research Field	Principal Investigator Functional basic dentistry / Animal physiology/Animal behavior Except Principal Investigator Functional basic dentistry
Keywords	Principal Investigator リン酸化 / 唾液腺 / 細胞内膜輸送 / ユビキチン化 / 翻訳後修飾 / アクアポリン / アクアポリン5 / 細胞内シグナル伝達 / 口腔生理学 / 細胞内輸送 … More / アクアポリン5(AQP5) / 結合タンパク質 / プルダウンアッセイ / 小胞輸送 / 腎臓集合管 / アクアポリン2 … More Except Principal Investigator 唾液腺 / HSG細胞 / bHLH型転写因子 / AQP5 / 水チャネル / PACE4 / サチライシン様前駆体蛋白質変換酵素 / 発生・分化・再生 / 腺房細胞 / 顎下腺 / 鼓索神経切除 / 遺伝子変異 / LPS / アクアポリン5 / GFP-AQP5キメラ分子 / トラフィッキング / MDCK細胞 / 塩酸セビメリン / 副交感神経 / カテプシン / アクアポリン Less

Molecular regulatory mechanisms for post-translational modifications of the water channel controlling salivary secretion.Principal Investigator
- Principal Investigator
  
  HASEGAWA Takahiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
病態時における外分泌腺型水チャネル、AQP5の発現と機能調節の分子機構
- Principal Investigator
  
  細井和雄
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Elucidation of the molecular mechanism on the differentiation/maturation and functional expression of salivary acinar cell toward conquest of xerostomia.
- Principal Investigator
  
  AKAMATSU Tetsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Physiological roles ofpost-translational modifications of water channel aquaporin-5 in the salivary glands.Principal Investigator
- Principal Investigator
  
  HASEGAWA Takahiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Regulation of posttranslational modification of water channel aquaporin-5 in the intracellular localization and traffickingPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Takahiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima
Gontrol of intracellular trafficking of water channel aquaporin-2Principal Investigator
- Principal Investigator
  
  HASEGAWA Takahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  The University of Tokushima
Moecular meohanism of expression and regulation of the water channe1, aquapor in 5 in the exocrine gland
- Principal Investigator
  
  HOSOI Kazuo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  The University of Tokushima

All 2013 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013
- Author(s)
  赤松徹也，姚陳娟，長谷川敬展，吉村弘
- Journal Title
  
  J. Oral Biosci.
  
  Volume: Suppl. Pages: 199-199
- Data Source
  KAKENHI-PROJECT-23592737
[Journal Article] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013
- Author(s)
  赤松徹也,姚陳娟,長谷川敬展,吉村弘
- Journal Title
  
  J. Oral Biosci
  
  Volume: Suppl Pages: 199-199
- Data Source
  KAKENHI-PROJECT-23592737
[Journal Article] Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats2011
- Author(s)
  Karabasil MR, Hasegawa T, Hosoi K (他5名, 2番目)
- Journal Title
  
  Biol Cell 103
  
  Pages: 69-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791806
[Journal Article] Novel Phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells2011
- Author(s)
  Hasegawa T, et al
- Journal Title
  
  American Journal of Physiology-Cell Physiology
  
  Volume: 301(3) Issue: 3 Pages: C667-C678
- DOI
  10.1152/ajpcell.00058.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592736, KAKENHI-PROJECT-23792124
[Journal Article] Localization of water channels in the skin of two species of desert toads, Anaxyrus (Bufo) punctatus and Incilius (Bufo) alvarius2011
- Author(s)
  Shibata Y, Takeuchi HA, Hasegawa T, Suzuki M, Tanaka S, Hillyard SD, Nagai T
- Journal Title
  
  Zool Sci.
  
  Volume: 28 Issue: 9 Pages: 664-670
- DOI
  10.2108/zsj.28.664
- NAID
  40018988020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570075, KAKENHI-PROJECT-23792124
[Journal Article] Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kB and p-c-Jun/c-Fos.2010
- Author(s)
  Yao C, Hasegawa T, Hosoi K.(他7名, 6 番目)
- Journal Title
  
  Am J Pathol 177
  
  Pages: 724-734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791806
[Journal Article] Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation2010
- Author(s)
  Azlina A, Hasegawa T, Hosoi K.(他4名, 4番目)
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791806
[Journal Article] Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif ((152)SRRTS) in MDCK-II cells.2009
- Author(s)
  Karabasil MR, Hasegawa T, Azlina A, Purwanti N, Purevjav J, Yao C, Akamatsu T, Hosoi K.
- Journal Title
  
  J Med Invest 56
  
  Pages: 55-63
- NAID
  130004465167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770054
[Journal Article] Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland2009
- Author(s)
  Akamatsu T, Azlina A, Purwanti N, Karabasil MR, Hasegawa T, Yao C, Hosoi K
- Journal Title
  
  Dev Biol 325
  
  Pages: 434-443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770054
[Journal Article] Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif(152SRRTS) in MDCK-II cells2009
- Author(s)
  Karabasil, M.R., T. Hasegawa, A. Azlina, N. Purwanti, J.Purevjav, C. Yao, T. Akamatsu and K. Hosoi
- Journal Title
  
  The Journal of Medical Investigation 56(1, 2)
  
  Pages: 55-63
- NAID
  130004465167
- Data Source
  KAKENHI-PROJECT-18390493
[Journal Article] Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland2009
- Author(s)
  Akamatsu, T., A. Azlina, N. Purwanti, M.R. Karabasil, T. Hasegawa, C. Yao, and K. Hosoi
- Journal Title
  
  Developmental Biology 325(2)
  
  Pages: 434-443
- Data Source
  KAKENHI-PROJECT-18390493
[Journal Article] Localization and trafficking of aquaporin 2 in the kidney2008
- Author(s)
  Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T
- Journal Title
  
  Histochem Cell Biol 130
  
  Pages: 197-209
- Data Source
  KAKENHI-PROJECT-19770054
[Journal Article] Degradation of submandibular gland AQP5 by parasympathetic denervation of chords tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist2008
- Author(s)
  Li X., A. Azlina, M.R. Karabasil, N. Purwanti, T. Hasegawa, C. Yao, T. Akamatsu, and K. Hosoi
- Journal Title
  
  American Journal of Physiology-Gastrointestinal and Liver Physiology 295(1)
  
  Pages: 112-123
- Data Source
  KAKENHI-PROJECT-18390493
[Journal Article] Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist2008
- Author(s)
  LiX, Azlina A, Karabasil MR, Purwanti N, Hasegawa T, Yao C, Akamatsu T, Hosoi K
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770054
[Presentation] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013
- Author(s)
  赤松徹也，姚陳娟，長谷川敬展，吉村弘
- Organizer
  第55回歯科基礎医学会
- Place of Presentation
  岡山コンベンションセンター（岡山県）
- Data Source
  KAKENHI-PROJECT-23592737
[Presentation] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013
- Author(s)
  赤松徹也,姚陳娟,長谷川敬展,吉村弘
- Organizer
  第55回歯科基礎医学会
- Place of Presentation
  (岡山コンベンションセンター/岡山県)
- Data Source
  KAKENHI-PROJECT-23592737
[Presentation] 唾液腺細胞におけるアクアポリン5の翻訳後修飾2011
- Author(s)
  長谷川敬展
- Organizer
  第53回歯科基礎医学会学術大会・総会サテライトシンポジウム
- Place of Presentation
  長良川国際会議場（岐阜県）
- Data Source
  KAKENHI-PROJECT-23792124
[Presentation] 唾液腺細胞におけるアクアポリン5の翻訳後修飾2011
- Author(s)
  長谷川敬展
- Organizer
  第53回歯科基礎医学会サテライトシンポジウム11「唾液腺談話会」
- Place of Presentation
  長良川国際会議場(岐阜)
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-23592736
[Presentation] 唾液腺細胞におけるアクアポリン 5 の翻訳後修2011
- Author(s)
  長谷川敬展
- Organizer
  第53回歯科基礎医学会学術大会・総会サテライトシンポジウム
- Place of Presentation
  長良川国際会議場(岐阜市)
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-23792124
[Presentation] 唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構2010
- Author(s)
  長谷川敬展
- Organizer
  第52回歯科基礎医学会学術大会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-21791806
[Presentation] 唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構2010
- Author(s)
  長谷川敬展、アズリナアハマド、ジャフランフルジャフ、廣島佑香、姚陳娟、赤松徹也、細井和雄
- Organizer
  第52回歯科基礎医学会学術大会・総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-21791806
[Presentation] アクアポリン5のユビキチン化とその細胞内輸送系における役割2009
- Author(s)
  長谷川敬展
- Organizer
  第51回歯科基礎医学会学術大会
- Place of Presentation
  朱鷺メッセ(新潟県)
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21791806
[Presentation] アクアポリン5のユビキチン化とその細胞内輸送系における役割2009
- Author(s)
  長谷川敬展、アズリナアハマド、ジャフランフルジャフ、姚陳娟、赤松徹也、細井和雄
- Organizer
  第51回歯科基礎医学会学術大会・総会
- Place of Presentation
  新潟市
- Data Source
  KAKENHI-PROJECT-21791806
[Presentation] ヒト唾液腺HSG細胞における構成的なAQP5 の取り込み
- Author(s)
  長谷川敬展、姚陳娟、赤松徹也、吉村弘
- Organizer
  第55回歯科基礎医学会学術大会・総会
- Place of Presentation
  岡山県岡山市（岡山コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-25462891
[Presentation] ユビキチンリガーゼによるAQP5のユビキチン化亢進とダウンレギュレーション
- Author(s)
  長谷川敬展、姚陳娟、赤松徹也、吉村弘
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡県福岡市（福岡国際会議場）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25462891

1. HOSOI Kazuo (10049413)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. AKAMATSU Tetsuya (80294700)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. YAO Chenjuan (20432750)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. KANAMORI Norio (90064865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YOSHIMURA Hiroshi (90288845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 李雪飛

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NUNUK Purwanti

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MILEVA Ratko Karabasil

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AZLINA Ahmad

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. JAVKHLAN Purevjav

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鈴木雅一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hasegawa Takahiro 長谷川 敬展

HASEGAWA Takahiro 長谷川 敬展

Research Projects

Research Products

Co-Researchers

Molecular regulatory mechanisms for post-translational modifications of the water channel controlling salivary secretion.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

病態時における外分泌腺型水チャネル、AQP5の発現と機能調節の分子機構

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the molecular mechanism on the differentiation/maturation and functional expression of salivary acinar cell toward conquest of xerostomia.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological roles ofpost-translational modifications of water channel aquaporin-5 in the salivary glands.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of posttranslational modification of water channel aquaporin-5 in the intracellular localization and traffickingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gontrol of intracellular trafficking of water channel aquaporin-2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Moecular meohanism of expression and regulation of the water channe1, aquapor in 5 in the exocrine gland

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013

Author(s)

Journal Title

Data Source

[Journal Article] 唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与2013

Author(s)

Journal Title

Data Source

[Journal Article] Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats2011

Author(s)

Journal Title

Data Source

[Journal Article] Novel Phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Localization of water channels in the skin of two species of desert toads, Anaxyrus (Bufo) punctatus and Incilius (Bufo) alvarius2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kB and p-c-Jun/c-Fos.2010

Author(s)

Journal Title

Data Source

[Journal Article] Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation2010

Author(s)

Journal Title

Data Source

[Journal Article] Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif ((152)SRRTS) in MDCK-II cells.2009

Author(s)

Hasegawa Takahiro 長谷川敬展

HASEGAWA Takahiro 長谷川敬展