Hirai-Yuki Asuka 結城明香

… Alternative Names

平井明香ヒライアスカ

HIRAI Asuka 平井明香

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Researcher Number	50450557
Other IDs	https://orcid.org/0000-0002-1218-8333
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所安全管理研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2024: 国立感染症研究所, 安全管理研究センター, 主任研究官 2019 – 2024: 国立感染症研究所, 安全実験管理部, 主任研究官 2018: 国立感染症研究所, 動物管理室, 主任研究官 2011: 国立感染症研究所, 動物管理室, 主任研究官 2007: 国立感染症研究所, ウイルス第3部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Basic Section 42020:Veterinary medical science-related / Laboratory animal science Except Principal Investigator Basic Section 49060:Virology-related / Virology
Keywords	Principal Investigator A型肝炎ウイルス / 経口感染 / マウスモデル / III型IFN / 腸管 / 自然免疫 / 肝炎ウイルス / I・III型IFN受容体遺伝子欠損マウス / A型肝炎 / ウイルス … More / 感染症 / 受容体 / ウイルス感染症 / 実験動物 / マウス肝炎ウイルス … More Except Principal Investigator ウイルス / 肝炎ウイルス / インターフェロン制御因子 / 自然免疫 / スパイク(S)蛋白 / 脳内継代 / 乳飲みマウス / ブタ伝染性下痢ウイルス(PEDV) / recetor-indeendent infection / マウス肝炎ウイルス / ウイルス受容体 / 巨細胞形成 / 神経病原性 / 豚下痢症ウイルス(PEDV) / コロナウイルス / 病原性 Less

Mechanisms by which Hepatitis A virus overcomes the intestinal barrier to reach the liverPrincipal Investigator
- Principal Investigator
  
  結城明香
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Institute of Infectious Diseases
基底レベルの感染防御を担うウイルス抑制シグナルの解明
- Principal Investigator
  
  山根大典
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Intestinal innate immune response to enterically transmitted hepatitis virusPrincipal Investigator
- Principal Investigator
  
  Hirai-Yuki Asuka
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  National Institute of Infectious Diseases
マウス肝炎ウイルスに対する抵抗性機構の解明と抵抗性マウスの樹立Principal Investigator
- Principal Investigator
  
  平井明香
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  National Institute of Infectious Diseases
Studies on receptor-independent infection of coronaviruses and its implication in the pathogenesis
- Principal Investigator
  
  TAGUCHI Fumihiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases

All 2023 2022 2021 2019 2018 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] SNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling2023
- Author(s)
  Matsumoto M, Modliszewski JL, Shinozaki K, Maezawa R, Perez VM, Ishikawa Y, Suzuki R, McKnight KL, Masaki T, Hirai-Yuki A, Kohara M, Lemon SM, Selitsky SR, Yamane D
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 9 Pages: 4451-4466
- DOI
  10.1093/nar/gkad298
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08342, KAKENHI-PROJECT-23K21382
[Journal Article] Macrophage depletion reactivates fecal virus shedding following resolution of acute hepatitis A in Ifnar1-/- mice.2022
- Author(s)
  Shiota T, Matsuda M, Zheng X, Nagata N, Ishii K, Suzuki R, Muramatsu M, Takimoto K, Hanaki K, Lemon SM, McGivern D, Hirai-Yuki A
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 23 Pages: 1-14
- DOI
  10.1128/jvi.01496-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08852, KAKENHI-PROJECT-19H03626, KAKENHI-PROJECT-18K05987
[Journal Article] IRF3-mediated pathogenicity in a murine model of human hepatitis A2021
- Author(s)
  Sun Lu、Li You、Misumi Ichiro、Gonz?lez-L?pez Olga、Hensley Lucinda、Cullen John M.、McGivern David R.、Matsuda Mami、Suzuki Ryosuke、Sen Ganes C.、Hirai-Yuki Asuka、Whitmire Jason K.、Lemon Stanley M.
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 9 Pages: 1-23
- DOI
  10.1371/journal.ppat.1009960
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05987, KAKENHI-PROJECT-20K08852
[Journal Article] Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses2019
- Author(s)
  Yamane D, Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK, Lemon SM
- Journal Title
  
  Nature Microbiology
  
  Volume: 印刷中 Issue: 7 Pages: 1096-1104
- DOI
  10.1038/s41564-019-0425-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05987, KAKENHI-PROJECT-17H05070, KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-17K08870
[Journal Article] Murine Models of Hepatitis A Virus Infection2018
- Author(s)
  Hirai-Yuki Asuka、Whitmire Jason K.、Joyce Michael、Tyrrell D. Lorne、Lemon Stanley M.
- Journal Title
  
  Cold Spring Harbor Perspectives in Medicine
  
  Volume: 9 Issue: 1 Pages: a031674-a031674
- DOI
  10.1101/cshperspect.a031674
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05987
[Journal Article] Mouse hepatitis virus receptor as a determinant of the mouse susceptibility to MHV infection2012
- Author(s)
  Fumihiro Taguchi and Asuka Hirai-Yuki
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 3 Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700520
[Journal Article] Role of mouse hepatitis virus (MHV) receptor mCEACAM1 in the resistance of mice to MHV infection: Studies on mice with chimeric mCEACAM1a and 1b.2010
- Author(s)
  Hirai A, Ohtsuka N, Ikeda T, Taniguchi R, Blau D, Nakagaki K, Miura HS, Ami Y, Yamada YK, Itohara S, Holmes KV, Taguchi F
- Journal Title
  
  J. Virol 84(In press)
- Data Source
  KAKENHI-PROJECT-19390135
[Presentation] 抗HAVヒト抗体の単離および動物モデルを使った抗HAV効果の検討2023
- Author(s)
  鄭シン、平井-結城明香、寺原和孝、渡邉則幸、塩田智之、小谷治、山根大典、深野顕人、大崎恵理子、小野寺大志、安達悠、若江亨祥、滝本一広、永田典代、加藤孝宣、相崎英樹、上田啓次、鈴木亮介、高橋宜聖、村松正道
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 動物モデルにおけるヒトモノクロ抗HAV抗体の感染阻止効果の検討2023
- Author(s)
  鄭シン、平井-結城明香、寺原和孝、渡邉則幸、塩田智之、小谷治、山根大典、深野顕人、大崎恵理子、小野寺大志、安達悠、佐藤由子、大園誠也、若江亨祥、滝本一広、永田典代、加藤孝宣、相崎英樹、上田啓次、鈴木亮介、高橋宜聖、村松正道
- Organizer
  第31回日本抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] 肝炎ウイルス複製を抑制する肝細胞内シグナル伝達の解析と創薬への応用2022
- Author(s)
  山根大典、結城明香
- Organizer
  TOBIRA第10回研究交流フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] レポーター遺伝子を持つ組換えA型肝炎ウイルスを用いた抗ウイルス低分子化合物の探索2021
- Author(s)
  鈴木亮介、松田麻未、西山直子、小林さくら、鈴木祐成、清原知子、結城（平井）明香、山根大典、村松正道
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21382
[Presentation] RARRES3 mediates interferon regulatory factor 1-induced suppression of hepatitis A virus replication through modulation of the mTOR activity.2019
- Author(s)
  Daisuke Yamane, Asuka Hirai-Yuki, Michinori Kohara, and Stanley M. Lemon.
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05987
[Presentation] MAVS-independent activity of interferon regulatory factor 1 restricts replication of hepatotropic RNA viruses.2018
- Author(s)
  Daisuke Yamane，Asuka Hirai-Yuki，Michinori Kohara，Stanley M Lemon.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K05987
[Presentation] 異なるマウス系統間にみられるマウス肝炎ウイルス感受性差の解析2012
- Author(s)
  平井(結城)明香, 山田靖子, 田口文広
- Organizer
  第154回日本獣医学会
- Place of Presentation
  岩手県盛岡市
- Data Source
  KAKENHI-PROJECT-23700520
[Presentation] Difference in MHV receptor activity between CEACAM1b and CEACAm1ba expressed in mice but not in cultured cell lines2011
- Author(s)
  Asuka Hirai-Yuki, Yasuko K Yamada and Fumihiro Taguchi
- Organizer
  The XIIth International Nidovirus sympodium
- Place of Presentation
  Michigan, USA
- Data Source
  KAKENHI-PROJECT-23700520
[Presentation] Role of mouse hepatitis virus (MHV) receptor in the resistance of mice to MHV infection as revealed by Ceacam-1 gene replaced mice.2009
- Author(s)
  Hirai A
- Organizer
  The 9^<th> Awaji International Forum on Infection and Immunity.
- Place of Presentation
  淡路
- Year and Date
  2009-09-08
- Data Source
  KAKENHI-PROJECT-19390135
[Presentation] マウス系統間におけるマウス肝炎ウイルス感受性差に関する解析2009
- Author(s)
  平井明日香
- Organizer
  第57回日本ウイルス学会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-19390135

1. 山根大典 (60782761)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. TAGUCHI Fumihiro (30107429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. WATANABE Rihito (30129746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SHIRATO Kazuya (40415477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MASAKI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 鈴木亮介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirai-Yuki Asuka 結城 明香

平井 明香 ヒライ アスカ

HIRAI Asuka 平井 明香

Research Projects

Research Products

Co-Researchers

Mechanisms by which Hepatitis A virus overcomes the intestinal barrier to reach the liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

基底レベルの感染防御を担うウイルス抑制シグナルの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intestinal innate immune response to enterically transmitted hepatitis virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウス肝炎ウイルスに対する抵抗性機構の解明と抵抗性マウスの樹立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on receptor-independent infection of coronaviruses and its implication in the pathogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] SNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophage depletion reactivates fecal virus shedding following resolution of acute hepatitis A in Ifnar1-/- mice.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IRF3-mediated pathogenicity in a murine model of human hepatitis A2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Murine Models of Hepatitis A Virus Infection2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mouse hepatitis virus receptor as a determinant of the mouse susceptibility to MHV infection2012

Author(s)

Journal Title

Data Source

[Journal Article] Role of mouse hepatitis virus (MHV) receptor mCEACAM1 in the resistance of mice to MHV infection: Studies on mice with chimeric mCEACAM1a and 1b.2010

Author(s)

Journal Title

Data Source

[Presentation] 抗HAVヒト抗体の単離および動物モデルを使った抗HAV効果の検討2023

Author(s)

Organizer

Data Source

[Presentation] 動物モデルにおけるヒトモノクロ抗HAV抗体の感染阻止効果の検討2023

Author(s)

Organizer

Data Source

[Presentation] 肝炎ウイルス複製を抑制する肝細胞内シグナル伝達の解析と創薬への応用2022

Author(s)

Organizer

Hirai-Yuki Asuka 結城明香

平井明香ヒライアスカ

HIRAI Asuka 平井明香