Ihara Hideyuki 井原秀之

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IHARA Hideyuki 井原秀之

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Researcher Number	50452834
Other IDs	https://orcid.org/0000-0003-0490-6355
Affiliation (Current)	2025: 佐賀大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 佐賀大学, 医学部, 准教授 2013: 佐賀大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Biofunction/Bioprocess Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Analytical chemistry
Keywords	Principal Investigator FUT8 / 糖転移酵素 / 活性型二量体 / 平衡反応 / α-helical ドメイン / SH3ドメイン / 活性型二量体形成 / 活性型 / 二量体 / 酵素 … More / 糖鎖 / グライコエンジニアリング / アスパラギン結合型糖鎖 / Ｎ型糖鎖改変 / SH3 domain / αヘリックス / ダイマー / コアフコース / 翻訳後修飾 / N型糖鎖 / フコース転移酵素 … More Except Principal Investigator 糖尿病 / 糖・脂質代謝制御 / 抗肥満 / 阻害剤 / ミトコンドリア / 褐色脂肪組織 / crebp / 糖・脂質代謝 / 肥満 / メタボリックシンドローム / 転写因子 / ChREBP / エネルギー代謝 / 糖代謝 / NO / ニトロ化 / NAD+ / 糖転移酵素 / 構造決定 / 糖鎖構造 / 逆反応 / 糖ヌクレオチド / フコース転移酵素 / 糖鎖 Less

NAD+の構造変化による細胞内代謝の変化と糖尿病・老化への関与
- Principal Investigator
  
  江口裕伸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hyogo Medical University
FUT8が関わる２つの化学平衡に基づいた疾病時細胞内コアフコース生合成の理解Principal Investigator
- Principal Investigator
  
  井原秀之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Saga University
FUT8二量体化機構を標的にした炎症性疾患・がんの治療薬の開発Principal Investigator
- Principal Investigator
  
  井原秀之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Saga University
Improvement of metabolic syndrome by inhibiting activation of ChREBP
- Principal Investigator
  
  sakiyama haruhiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Senri Kinran University
  Hyogo Medical University
Structural modification of NAD+ by peroxynitrite attenuates cellular metabolism and is involved in metabolic diseases
- Principal Investigator
  
  Eguchi Hironobu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hyogo Medical University
Protein engineering of human FUT8 for efficient production of core fucosylated glycoproteinsPrincipal Investigator
- Principal Investigator
  
  Ihara Hideyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Saga University
Oligosaccharide degradation based on the reverse reaction by glycosyltrasnferase
- Principal Investigator
  
  TEI Bungyoku (IKEDA Yoshitaka)
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Saga University

All 2023 2022 2021 2020 2019 2018 2017 2014 2013 2012

All Journal Article Presentation Book

[Book] Mannosyl (beta-1, 4-)-glycoprotein beta-1, 4-Nacetylglucosaminyltransferase (MGAT3) ; β 1, 4-N- Acetylglucosaminyltransferase III (GnT-III, GlcNAc-T III). In : Handbook of Glycosyltransferases and Related Genes 2nd ed. Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (Eds.)2014
- Author(s)
  Ikeda Y, Ihara H, Tsukamoto H, Gu J, Taniguchi N
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23550099
[Book] Fucosyltransferase 8. GDP-fucose N-glycan core α 6-fucosyltransferase (FUT8). In : Handbook of Glycosyltransferases and Related Genes 2nd ed. Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (Eds.)2014
- Author(s)
  Ihara H, Tsukamoto H, Gu J, Miyoshi E, Taniguchi N, Ikeda Y
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23550099
[Journal Article] ChREBP deficiency prevents high sucrose diet-induced obesity through reducing sucrase expression2022
- Author(s)
  Sakiyama Haruhiko, Li Lan, Inoue Minako, Eguchi Hironobu, Yoshihara Daisaku, Fujiwara Noriko, Suzuki Keiichiro.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 71 Issue: 3 Pages: 221-228
- DOI
  10.3164/jcbn.22-15
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11570
[Journal Article] Iron deficiency aggravates DMNQ-induced cytotoxicity via redox cycling in kidney-derived cells2022
- Author(s)
  Yoshihara Daisaku、Fujiwara Noriko、Eguchi Hironobu、Sakiyama Haruhiko、Suzuki Keiichiro
- Journal Title
  
  Free Radical Research
  
  Volume: 56 Issue: 7-8 Pages: 544-554
- DOI
  10.1080/10715762.2022.2154668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11478, KAKENHI-PROJECT-20K11570
[Journal Article] The Roles of the N-terminal α-helical and C-terminal Src Homology 3 Domains in the Enzymatic Functions of FUT82021
- Author(s)
  Ihara Hideyuki、Ikeda Yoshitaka
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 33 Issue: 193 Pages: E69-E73
- DOI
  10.4052/tigg.2025.1E
- NAID
  130008042838
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2021-05-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11647
[Journal Article] The Roles of the N-terminal α-helical and C-terminal Src Homology 3 Domains in the Enzymatic Functions of FUT82021
- Author(s)
  井原秀之、池田義孝
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 33 Issue: 193 Pages: J69-J73
- DOI
  10.4052/tigg.2025.1J
- NAID
  130008042839
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2021-05-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11647
[Journal Article] A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue2021
- Author(s)
  Sakiyama H, Li L, Kuwahara-Otani S, Nakagawa T, Eguchi H, Yoshihara D, Shinohara M, Fujiwara N, Suzuki K.
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 476 Issue: 10 Pages: 3577-3590
- DOI
  10.1007/s11010-021-04178-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11570, KAKENHI-PROJECT-20K11628
[Journal Article] Activation of the mitogen-activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells2021
- Author(s)
  Li L, Sakiyama H, Eguchi H, Yoshihara D, Fujiwara N, Suzuki K
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 7 Pages: 2008-2018
- DOI
  10.1002/2211-5463.13208
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11570
[Journal Article] Involvement of the α-helical and Src homology 3 domains in the molecular assembly and enzymatic activity of human α1,6-fucosyltransferase, FUT82020
- Author(s)
  Ihara Hideyuki、Okada Takahiro、Taniguchi Naoyuki、Ikeda Yoshitaka
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1864 Issue: 7 Pages: 129596-129596
- DOI
  10.1016/j.bbagen.2020.129596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K06929
[Journal Article] Difucosylation of chitooligosaccharides by eukaryote and prokaryote alpha1,6-fucosyltransferases.2013
- Author(s)
  Ihara H, Hanashima S, Tsukamoto H, Yamaguchi Y, Taniguchi N, Ikeda Y
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1830 Issue: 10 Pages: 4482-4490
- DOI
  10.1016/j.bbagen.2013.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Journal Article] Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells.2013
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M
- Journal Title
  
  J. Immunol.
  
  Volume: 190 Issue: 1 Pages: 195-204
- DOI
  10.4049/jimmunol.1201047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24590577, KAKENHI-PROJECT-24591466, KAKENHI-PROJECT-24790112
[Journal Article] MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface.2013
- Author(s)
  Tsukamoto H, Ihara H, Ito R, Ukai I, Suzuki N, Kimoto M, Tomioka Y, Ikeda Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 440 Issue: 1 Pages: 31-36
- DOI
  10.1016/j.bbrc.2013.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112, KAKENHI-PROJECT-25430135
[Journal Article] An assay for alpha1,6-fucosyltransferase (FUT8) activity based on the HPLC separation of a reaction product with fluorescence detection.2013
- Author(s)
  Ihara H, Tsukamoto H, Taniguchi N, Ikeda Y
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1022 Pages: 335-348
- DOI
  10.1007/978-1-62703-465-4_25
- ISBN
  9781627034647, 9781627034654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Journal Article] Measurement of Peroxiredoxin-4 in Rat Tissues and Implication of Its Serum Levels as a Potential Marker for Hepatic Disease.2012
- Author(s)
  Ritsu Ito
- Journal Title
  
  Mol Med Report
  
  Volume: 6 Issue: 2 Pages: 379-384
- DOI
  10.3892/mmr.2012.935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590262, KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs.2012
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M
- Journal Title
  
  Int. Immunol.
  
  Volume: 24 Issue: 8 Pages: 495-506
- DOI
  10.1093/intimm/dxs053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
[Presentation] コイルドコイルドメイン内に位置するアミノ酸側鎖の疎水性度の変化がヒトα1,6-フコース転移酵素（FUT8）の活性型形成に及ぼす影響2023
- Author(s)
  井原秀之, 岡田貴裕, 谷口直之, 池田義孝
- Organizer
  第96回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K11647
[Presentation] Effects of peroxynitrite on the fucosylation and phosphorylation of c-Met in HepG2 cells2022
- Author(s)
  Eguchi Hironobu, Hamazaki Shigeaki, Sakiyama Haruhiko, Yoshihara Daisaku, Fujiwara Noriko, Suzuki Keiichiro
- Organizer
  The 22nd Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Data Source
  KAKENHI-PROJECT-20K11570
[Presentation] ヒトα1,6 フコース転移酵素（ FUT8 ）の酵素活性に影響を及ぼす α ヘリカル（コイルドコイル）ドメイン内疎水性アミノ酸残基の探索2022
- Author(s)
  井原秀之、岡田貴裕、谷口直之、池田義孝
- Organizer
  第95回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K11647
[Presentation] 部位特異的変異導入によるFUT8活性型形成にかかわるα-ヘリカルドメインの機能解析2022
- Author(s)
  井原秀之、岡田貴裕、谷口直之、池田義孝
- Organizer
  第41回　日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K11647
[Presentation] ヒトα1,6-フコース転移酵素（FUT8）のα-ヘリカル（コイルドコイル）ドメインにおける高次構造形成に関わる疎水性アミノ酸の機能解析2021
- Author(s)
  井原秀之、岡田貴裕、谷口直之、池田義孝
- Organizer
  第94回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K11647
[Presentation] ヒトα1,6-フコース転移酵素の高次構造形成に関わるドメインの機能解析2019
- Author(s)
  井原秀之、岡田貴裕、谷口直之、池田義孝
- Organizer
  第92回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K06929
[Presentation] 糖鎖付加型α1,6-フコース転移酵素（FUT8）変異体の分泌型酵素の調整およびその機能解析2018
- Author(s)
  井原秀之、岡田貴裕、池田義孝
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K06929
[Presentation] ヒト α1,6-フコース転移酵素（FUT8）の部位特異的変異導入による翻訳後修飾の改変2017
- Author(s)
  井原秀之、岡田貴裕、池田義孝
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）（第40回　日本分子生物学会年会、第90回　日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-17K06929
[Presentation] Cloning, expression and characterization of silkworm a1,6-fucosyltransferase.2013
- Author(s)
  井原秀之，池田義孝
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23550099
[Presentation] Cloning, expression and characterization of silkworm a1, 6-fucosyltransferase2013
- Author(s)
  井原秀之, 池田義孝
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23550099
[Presentation] Reduced surface expression of TLR4 by a V254I point mutation may account for the low LPS responder phenotype of BALB/c B cells2012
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23550099
[Presentation] ヒト及び根瘤菌α 1, 6-fucosyltransferase を用いたジフコシル化キトオリゴ糖の合成2012
- Author(s)
  井原秀之, 花島慎弥, 塚本宏樹, 山口芳樹, 谷口直之, 池田義孝
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23550099
[Presentation] ヒト及び根瘤菌α1,6-fucosyltransferaseを用いたジフコシル化キトオリゴ糖の合成2012
- Author(s)
  井原秀之、花島慎弥、塚本宏樹、山口芳樹、谷口直之、池田義孝
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23550099

1. Eguchi Hironobu (60351798)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. sakiyama haruhiko (30508958)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. 吉原大作 (00567266)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. 鈴木敬一郎 (70221322)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. TEI Bungyoku (60252657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. 藤原範子 (10368532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 福島和明 (00273730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 江嵜啓祥 (40454889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ihara Hideyuki 井原 秀之

IHARA Hideyuki 井原 秀之

Research Projects

Research Products

Co-Researchers

NAD+の構造変化による細胞内代謝の変化と糖尿病・老化への関与

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

FUT8が関わる２つの化学平衡に基づいた疾病時細胞内コアフコース生合成の理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

FUT8二量体化機構を標的にした炎症性疾患・がんの治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Improvement of metabolic syndrome by inhibiting activation of ChREBP

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural modification of NAD+ by peroxynitrite attenuates cellular metabolism and is involved in metabolic diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Protein engineering of human FUT8 for efficient production of core fucosylated glycoproteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oligosaccharide degradation based on the reverse reaction by glycosyltrasnferase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Author(s)

Publisher

Data Source

[Book] Fucosyltransferase 8. GDP-fucose N-glycan core α 6-fucosyltransferase (FUT8). In : Handbook of Glycosyltransferases and Related Genes 2nd ed. Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (Eds.)2014

Author(s)

Publisher

Data Source

[Journal Article] ChREBP deficiency prevents high sucrose diet-induced obesity through reducing sucrase expression2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Iron deficiency aggravates DMNQ-induced cytotoxicity via redox cycling in kidney-derived cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Roles of the N-terminal α-helical and C-terminal Src Homology 3 Domains in the Enzymatic Functions of FUT82021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] The Roles of the N-terminal α-helical and C-terminal Src Homology 3 Domains in the Enzymatic Functions of FUT82021

Author(s)

Journal Title

DOI

NAID

Ihara Hideyuki 井原秀之

IHARA Hideyuki 井原秀之

[Presentation] ヒトα1,6 フコース転移酵素（ FUT8 ）の酵素活性に影響を及ぼす α ヘリカル（コイルドコイル）ドメイン内疎水性アミノ酸残基の探索2022

[Presentation] 部位特異的変異導入によるFUT8活性型形成にかかわるα-ヘリカルドメインの機能解析2022