Kimura Tomohiko 木村友彦

… Alternative Names

木村友彦キムラトモヒコ

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Researcher Number	50454830
Affiliation (Current)	2025: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 川崎医科大学, 医学部, 講師 2016 – 2018: 川崎医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Basic Section 59020:Sports sciences-related / Metabolomics
Keywords	Principal Investigator RNAメチレーション / SGLT2阻害薬 / GLP-1受容体作動薬 / 血流 / 膵島 / 糖尿病 / 虚血 / GLP-1 / 膵島血流 Except Principal Investigator 糖尿病 … More / インスリン転写因子 / 膵β細胞 / 次世代 / ビタミンD / エピゲノム / 脂肪組織 / 糖代謝 / 肝臓 / エピジェネティクス / 運動 / 妊娠 / 習慣的運動 / 肥満 / SOD3 / エクサカイン / プラセントカイン / 胎盤 / 妊娠期運動 / SGLT2阻害薬 / インクレチン受容体 / 新規糖尿病治療薬 / 膵β細胞糖毒性 / 転写因子 / インスリン遺伝子 / ブドウ糖毒性 Less

ブドウ糖毒性が膵ラ氏島のm6A RNAメチル化不全に与える影響Principal Investigator
- Principal Investigator
  
  木村友彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
膵β細胞ブドウ糖毒性から見た新規糖尿病治療薬の探索
- Principal Investigator
  
  金藤秀明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Mechanism of the beneficial effects of maternal exercise on next generation health focusing on maternal organs, placenta, and fetal tissues
- Principal Investigator
  
  Kusuyama Joji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Tokyo Medical and Dental University
  Tohoku University
Elucidation of a new mechanism of action of GLP-1 focusing on pancreatic islet blood flow - Investigation by in vivo imaging -Principal Investigator
- Principal Investigator
  
  Kimura Tomohiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Investigation of novel diabetic medicine based on glucose toxicity
- Principal Investigator
  
  Hideaki Kaneto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School

All 2022 2019 2018 2017 2016

All Journal Article

[Journal Article] Glucagon test is a useful predictor of withdrawal from insulin therapy in subjects with type 2 diabetes mellitus.2022
- Author(s)
  Iwamoto Y, Kimura T, Tatsumi F, Sugisaki T, Kubo M, Nakao E, Dan K, Wamata R, Iwamoto H, Takahashi K, Sanada J, Fushimi Y, Katakura Y, Shimoda M, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 13 Pages: 871660-871660
- DOI
  10.3389/fendo.2022.871660
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Correlation of Baba's diabetic neuropathy classification with various diabetes-related complications.2022
- Author(s)
  Iwamoto Y, Nakanishi S, Itoh T, Iwamoto H, Sanada J, Fushimi Y, Katakura Y, Kimura T, Tatsumi F, Shimoda M, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 13 Pages: 1054934-1054934
- DOI
  10.3389/fendo.2022.1054934
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus. Biomedicines.2022
- Author(s)
  Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Matsuoka TA, Kaku K.
- Journal Title
  
  Biomedicines.
  
  Volume: 31 Issue: 4 Pages: 818-831
- DOI
  10.3390/biomedicines10040818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08540, KAKENHI-PROJECT-22K08638
[Journal Article] Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules.2022
- Author(s)
  Sanada J, Obata A, Fushimi Y, Kimura T, Shimoda M, Ikeda T, Nogami Y, Obata Y, Yamasaki Y, Nakanishi S, Mune T, Kaku K, Kaneto H.
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 13220-13220
- DOI
  10.1038/s41598-022-17657-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08540, KAKENHI-PROJECT-22K08638
[Journal Article] Association between changes in pancreatic morphology and vascular complications in subjects with type 2 diabetes mellitus: A retrospective study.2022
- Author(s)
  Iwamoto Y, Kimura T, Tatsumi F, Sugisaki T, Kubo M, Nakao E, Dan K, Wamata R, Iwamoto H, Takahashi K, Sanada J, Fushimi Y, Katakura Y, Shimoda M, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Scientific Rep.
  
  Volume: 12 Issue: 1 Pages: 17166-17166
- DOI
  10.1038/s41598-022-21688-1
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Effect of hyperglycemia-related acute metabolic disturbance on thyroid function parameters in adults.2022
- Author(s)
  Iwamoto Y, Kimura T, Tatsumi F, Sugisaki T, Kubo M, Nakao E, Dan K, Wamata R, Iwamoto H, Takahashi K, Sanada J, Fushimi Y, Katakura Y, Shimoda M, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 13 Pages: 869869-869869
- DOI
  10.3389/fendo.2022.869869
- Data Source
  KAKENHI-PROJECT-22K08638
[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetologia
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic beta-cells in obese diabetic db/db mice: The earlier and longer, the better.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Okauchi S, Kanda-Kimura Y, Nogami Y, Hirukawa H, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Obes. Metab.
  
  Volume: 20 Pages: 2442-2457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced at all even after long-term exposure to dulaglutide.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Hirukawa H, Kanda-Kimura Y, Nogami Y, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Metab.
  
  Volume: 44 Pages: 250-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Pancreatic alpha-cells in diabetic rats express active GLP-1 receptor: Evidence for GLP-1 signaling that regulates intra-islet paracrine mechanism.2018
- Author(s)
  Nakashima K, Kaneto H, Shimoda M, Kimura T, and Kaku K.
- Journal Title
  
  Scientific Rep.
  
  Volume: 1 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-018-21751-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Beneficial effects of SGLT2 inhibitors for preservation of pancreatic beta-cell function and reduction of insulin resistance.2017
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Okauchi S, Shimo N, Matsuoka T, and Kaku K.
- Journal Title
  
  J. Diabetes
  
  Volume: 9 Issue: 3 Pages: 219-225
- DOI
  10.1111/1753-0407.12494
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Increase of cortisol / ACTH ratio after chronic treatment with liraglutide in subjects with type 2 diabetes mellitus.2017
- Author(s)
  Kamei S, Kaneto H, Tanabe A, Kinoshita T, Obata A, Kimura T, Hirukawa H, Tatsumi F, Shimoda M, Kohara K, Anno T, Nakanishi S, Mune T, and Kaku K.
- Journal Title
  
  Diabetes Metab
  
  Volume: 43 Issue: 4 Pages: 398-399
- DOI
  10.1016/j.diabet.2017.01.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Promising diabetes therapy based on the molecular mechanism for glucose toxicity: Usefulness of SGLT2 inhibitors as well as incretin-related drugs.2016
- Author(s)
  Kaneto H, Obata A, Shimoda M, Kimura T, Hirukawa H, Okauchi S, Matsuoka T, and Kaku K.
- Journal Title
  
  Curr. Med. Chem.
  
  Volume: 23 Pages: 3044-3051
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.2016
- Author(s)
  Okauchi S, Shimoda M, Obata A, Kimura T, Hirukawa H, Kohara K, Mune T, Kaku K, Kaneto H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 470 Issue: 3 Pages: 772-782
- DOI
  10.1016/j.bbrc.2015.10.109
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350, KAKENHI-PROJECT-16K09770
[Journal Article] Clinical effects of liraglutide are possibly influenced by hypertriglyceridemia and remaining pancreatic beta-cell function in subjects with type 2 diabetes mellitus.2016
- Author(s)
  Tanabe A, Kaneto H, Kamei S, Hirukawa H, Shimoda M, Kimura T, Obata A, Okauchi S, Tatsumi F, Kohara K, Mune T, and Kaku K.
- Journal Title
  
  J. Diabetes Complications
  
  Volume: 30 Pages: 1201-1203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770

1. Hideaki Kaneto (80448034)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. 下田将司 (60388957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. Kusuyama Joji (70596105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小畑淳史 (10771298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. 永富良一 (20208028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小塚智沙代 (70722370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 長名シオン (60868131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 片倉幸乃 (40858247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 真田淳平 (70771301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIRUKAWA Hidenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. OKAUCHI Seizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 加来浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Tomohiko 木村 友彦

木村 友彦 キムラ トモヒコ

Research Projects

Research Products

Co-Researchers

ブドウ糖毒性が膵ラ氏島のm6A RNAメチル化不全に与える影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膵β細胞ブドウ糖毒性から見た新規糖尿病治療薬の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of the beneficial effects of maternal exercise on next generation health focusing on maternal organs, placenta, and fetal tissues

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a new mechanism of action of GLP-1 focusing on pancreatic islet blood flow - Investigation by in vivo imaging -Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of novel diabetic medicine based on glucose toxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glucagon test is a useful predictor of withdrawal from insulin therapy in subjects with type 2 diabetes mellitus.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlation of Baba's diabetic neuropathy classification with various diabetes-related complications.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Mechanism of Pancreatic β-Cell Failure in Type 2 Diabetes Mellitus. Biomedicines.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between changes in pancreatic morphology and vascular complications in subjects with type 2 diabetes mellitus: A retrospective study.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of hyperglycemia-related acute metabolic disturbance on thyroid function parameters in adults.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019

Author(s)

Journal Title

Data Source

[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic beta-cells in obese diabetic db/db mice: The earlier and longer, the better.2018

Author(s)

Journal Title

Data Source

[Journal Article] Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced at all even after long-term exposure to dulaglutide.2018

Author(s)

Journal Title

Data Source

[Journal Article] Pancreatic alpha-cells in diabetic rats express active GLP-1 receptor: Evidence for GLP-1 signaling that regulates intra-islet paracrine mechanism.2018

Author(s)

Journal Title

Kimura Tomohiko 木村友彦

木村友彦キムラトモヒコ