SHIINA Masaaki 椎名正明

Researcher Number	50455820
Affiliation (based on the past Project Information) *help	2012 – 2014: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 2011 – 2012: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 共同研究員 2010: 東北大学, 大学院・医学系研究科, 非常勤講師
Review Section/Research Field	Principal Investigator Tumor biology / Gastroenterology
Keywords	Principal Investigator 胆道癌 / CD274 / がん幹細胞 / 肝炎 / 免疫 / ウィルス / 肝線維化 / HCV / 肝臓学

Role of CD274 in cancer stem cell of cholangicarcinomaPrincipal Investigator
- Principal Investigator
  
  SHIINA Masaaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Analysis of immunological reaction in liver using JFH-1 and establishment of novel therapyPrincipal Investigator
- Principal Investigator
  
  SHIINA Masaaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Miyagi Cancer Center Research Institute
  Tohoku University

All 2014 2012 2011 2010

All Journal Article Presentation

[Journal Article] Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma2014
- Author(s)
  Keiichi Tamai, Mao Nakamura, Masamichi Mizuma, Mai Mochizuki, Misa Yokoyama, Hiroyuki Endo, Kazunori Yamaguchi, Takayuki Nakagawa, Masaaki Shiina, Michiaki Unno, Koji Muramoto, Ikuro Sato, Kennichi Satoh, Kazuo Sugamura, and Nobuyuki Tanaka
- Journal Title
  
  Cancer Science
  
  Volume: 105 Issue: 6 Pages: 667-674
- DOI
  10.1111/cas.12406
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-25640073, KAKENHI-PROJECT-25860572, KAKENHI-PROJECT-26861427
[Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2012
- Author(s)
  Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue J, Fukushima K, Sano K, Ueno Y, Shimosegawa T, Sugamura K.
- Journal Title
  
  Virology
  
  Volume: 22(2) Issue: 2 Pages: 377-85
- DOI
  10.1016/j.virol.2011.11.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630, KAKENHI-PROJECT-23790762, KAKENHI-PROJECT-24300326
[Journal Article] In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis2011
- Author(s)
  Saeed M, Shiina M, Date T, Akazawa D, Watanabe N, Murayama A, Suzuki T, Watanabe H, Hiraga N, Imamura M, Chayama K, Choi Y, Krawczynski K, Liang TJ, Wakita T, Kato T
- Journal Title
  
  Hepatology
  
  Volume: 54 Issue: 2 Pages: 425-433
- DOI
  10.1002/hep.24399
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-23659407, KAKENHI-PROJECT-23790513
[Journal Article] Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-γ secretion activity2011
- Author(s)
  Kondo Y, Ueno Y, Kakazu E, Kobayashi K, Shiina M, Tamai K, Machida K, Inoue J, Wakui Y, Fukushima K, Obara N, Kimura O, Shimosegawa T
- Journal Title
  
  J Gastroenterol
  
  Volume: 46(2) Issue: 2 Pages: 232-41
- DOI
  10.1007/s00535-010-0297-2
- NAID
  10029027386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630
[Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein2010
- Author(s)
  Tamai K, Tanaka N, Nakano T, Kakazu E, Kondo Y, Inoue J, Shiina M, Fukushima K, Hoshino T, Sano K, Ueno Y, Shimosegawa T, Sugamura K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 399(3) Issue: 3 Pages: 384-90
- DOI
  10.1016/j.bbrc.2010.07.083
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630
[Journal Article] Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines2010
- Author(s)
  Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, Fukushima K, Shiina M, Yamagiwa Y, Kondo Y, Inoue J, Kakazu E, Iwasaki T, Kawagishi N, Shimosegawa T, Sugamura K
- Journal Title
  
  Cancer Sci.
  
  Volume: 101(10) Issue: 10 Pages: 2145-55
- DOI
  10.1111/j.1349-7006.2010.01661.x
- NAID
  10027832222
- Data Source
  KAKENHI-PROJECT-22590713
[Journal Article] Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes2010
- Author(s)
  Kondo Y, Ueno Y, Kobayashi K, Kakazu E, Shiina M, Inoue J, Tamai K, Wakui Y, Tanaka Y, Ninomiya M, Obara N, Fukushima K, Ishii M, Kobayashi T, Niitsuma H, Kon S, Shimosegawa T
- Journal Title
  
  J Infect Dis.
  
  Volume: 202(2) Issue: 2 Pages: 202-13
- DOI
  10.1086/653496
- Data Source
  KAKENHI-PROJECT-22590713, KAKENHI-PROJECT-22790630
[Presentation] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2010
- Author(s)
  Tamai K, Shiina M, Kondo Y, Kakazu E, Inoue J, Fukushima K, Ueno Y, Tanaka N, Shimosegawa T, Sugamura K
- Organizer
  17th International Meeting on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-22590713
[Presentation] 非代償性肝硬変のアミノ酸imbalanceは樹状細胞の成熟化を抑制し、分岐鎖アミノ酸(BCAA)により改善する2010
- Author(s)
  嘉数英二, 上野義之, 福島耕治, 近藤泰輝, 椎名正明, 井上淳, 玉井恵一, 小原範之, 木村修, 涌井祐太, 下瀬川徹
- Organizer
  静脈経腸栄養
- Place of Presentation
  東京
- Year and Date
  2010-02-25
- Data Source
  KAKENHI-PROJECT-22590713

1. TAMAI Keiichi (40509262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. KOBAYASHI Koju (30250781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMAGUCHI Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 茶山一彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田中伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIINA Masaaki 椎名 正明

Research Projects

Research Products

Co-Researchers

Role of CD274 in cancer stem cell of cholangicarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of immunological reaction in liver using JFH-1 and establishment of novel therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo adaptation of hepatitis C virus in chimpanzees for efficient virus production and evasion of apoptosis2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lymphotropic HCV strain can infect human primary naive CD4+ cells and affect their proliferation and IFN-γ secretion activity2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines2010

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes2010

Author(s)

Journal Title

DOI

Data Source

[Presentation] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2010

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 非代償性肝硬変のアミノ酸imbalanceは樹状細胞の成熟化を抑制し、分岐鎖アミノ酸(BCAA)により改善する2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SHIINA Masaaki 椎名正明