Hosojima Michihiro 細島康宏

Researcher Number	50464003
Other IDs
Affiliation (Current)	2025: 新潟大学, 医歯学総合研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 新潟大学, 医歯学総合研究科, 特任准教授 2014 – 2015: 新潟大学, 医歯(薬)学総合研究科, 特任准教授
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related Except Principal Investigator Basic Section 53040:Nephrology-related
Keywords	Principal Investigator メガリン / バイオマーカー / 尿中バイオマーカー / 近位尿細管 / 糖尿病性腎症 / SGLT2阻害薬 / エンドサイトーシス / 糖尿病性腎臓病 / 糖尿病 / 尿中メガリン / 肥満関連腎症 / エクソソーム … More Except Principal Investigator … More 慢性腎臓病 / メガリン / 糖尿病性腎臓病 / 創薬 / 急性腎障害 / コホート研究 / 抗刷子縁抗体病 / 23Na-MRI / Na / diabetic model mouse / Nephrotic syndrome / ネフローゼ症候群 / 対向流増幅系 / ナトリウム / 23Na MRI / MRI / バイオマーカー Less

抗刷子縁抗体病の実態調査と病態解明に関する研究
- Principal Investigator
  
  蒲澤秀門
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
前向きコホート10年追跡による尿細管マーカーのCKD発症・進展予測能の検討
- Principal Investigator
  
  蒲澤佳子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
メガリンの構造と機能の精密解析に基づく腎臓病の病態解明と診断・治療の新たな創薬
- Principal Investigator
  
  斎藤亮彦
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Analyzing the Pathophysiological Mechanisms of Nephrotic Syndrome using 23Na-MRI
- Principal Investigator
  
  Kaseda Ryohei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Urinary excretion mechanism of a novel urinary biomarker of diabetic kidney disease, extracellular domain type of megalinPrincipal Investigator
- Principal Investigator
  
  HOSOJIMA MICHIHIRO
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Development of megalin-targeted strategies for diagnosis, prevention, and treatment of chronic kidney disease and acute kidney injury
- Principal Investigator
  
  Saito Akihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Significance of urinary megalin excretion linked to the pathophysiology of obesity- or metabolic syndrome-related nephropathyPrincipal Investigator
- Principal Investigator
  
  Hosojima Michihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Investigation of the mechanism underlying urinary excretion of megalin, a novel biomarker of diabetic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Hosojima Michihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University

All 2023 2022 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] The endocytosis receptor megalin: From bench to bedside2023
- Author(s)
  Goto S, Hosojima M, Kabasawa H, Saito A
- Journal Title
  
  International Journal of Biochemistry and Cell Biology
  
  Volume: 15 Pages: 106393-106393
- DOI
  10.1016/j.biocel.2023.106393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21436
[Journal Article] Urinary A- and C-megalin predict progression of diabetic kidney disease : an exploratory retrospective cohort study2022
- Author(s)
  Iida Tomomichi、Hosojima Michihiro、Kabasawa Hideyuki、Yamamoto-Kabasawa Keiko、Goto Sawako、Tanaka Takahiro、Kitamura Nobutaka、Nakada Mitsutaka、Itoh Shino、Ogasawara Shinya、Kaseda Ryohei、Suzuki Yoshiki、Narita Ichiei、Saito Akihiko
- Journal Title
  
  Journal of Diabetes and its Complications
  
  Volume: 36 Issue: 11 Pages: 108312-108312
- DOI
  10.1016/j.jdiacomp.2022.108312
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09690, KAKENHI-PROJECT-23K21436
[Journal Article] Exocytosis-Mediated Urinary Full-Length Megalin Excretion is Linked with the Pathogenesis of Diabetic Nephropathy2017
- Author(s)
  De S, Kuwahara S, Hosojima M, Ishikawa T, Kaseda R, Sarkar P, Yoshioka Y, Kabasawa H, Iida T, Goto S, Toba K, Higuchi Y, Suzuki Y, Hara M, Kurosawa H, Narita I, Hirayama Y, Ochiya T, Saito A
- Journal Title
  
  Diabetes
  
  Volume: in press Issue: 5 Pages: 1391-1404
- DOI
  10.2337/db16-1031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293201, KAKENHI-PROJECT-26461216, KAKENHI-PROJECT-26670429, KAKENHI-PROJECT-26860630
[Patent] シクロデキストリン誘発腎障害の抑制2022
- Inventor(s)
  斎藤亮彦，後藤佐和子，細島康宏，蒲澤秀門，平山吉朗
- Industrial Property Rights Holder
  斎藤亮彦，後藤佐和子，細島康宏，蒲澤秀門，平山吉朗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-194619
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] 2型糖尿病患者における尿中メガリンの腎予後予測能の検討2022
- Author(s)
  飯田倫理，細島康宏，蒲澤秀門，蒲澤佳子，後藤佐和子，田中崇裕，北村信隆，忰田亮平，鈴木芳樹，成田一衛，斎藤亮彦
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] 溶血関連腎症におけるメガリンの役割とその治療戦略2022
- Author(s)
  後藤佐和子，細島康宏，蒲澤秀門，成田一衛，斎藤亮彦
- Organizer
  第65回日本腎臓学会年次学術総会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] SGLT2阻害薬使用時における尿中メガリンおよびメガリンリガンド分子の動態2022
- Author(s)
  細島康宏、蒲澤秀門、後藤佐和子、鈴木芳樹、成田一衛、斎藤亮彦
- Organizer
  第37回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] 2型糖尿病患者における尿中メガリン測定による腎予後予測2022
- Author(s)
  飯田倫理，細島康宏，蒲澤秀門，蒲澤佳子，後藤佐和子，田中崇裕，北村信隆，忰田亮平，鈴木芳樹，成田一衛，斎藤亮彦
- Organizer
  第65回日本腎臓学会年次学術総会
- Data Source
  KAKENHI-PROJECT-23K21436
[Presentation] Two forms of urinary megalin excretion are novel predictors of the progression of early-stage diabetic kidney disease in type 2 diabetes2018
- Author(s)
  Tomomichi Iida, Michihiro Hosojima, et al.
- Organizer
  ISN Frontiers Meetings
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09690
[Presentation] 早期の糖尿病腎症における腎予後予測マーカーとしての尿中メガリン測定の意義2017
- Author(s)
  飯田倫理，細島康宏ら
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09690
[Presentation] Mechanisms underlying urinary excretion of full-length and extracellular domain forms of megalin2016
- Author(s)
  Shankhajit De，Shoji Kuwahara，Michihiro Hosojima，Tomomi Ishikawa，Ryohei Kaseda，Yusuke Yoshioka，Yoshiki Suzuki，Ichiei Narita，Takahiro Ochiya，Hiroyuki Kurosawa, Yoshiaki Hirayama, Akihiko Saito
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26860630
[Presentation] Mechanism of Increased Urinary Full-Length Megalin Excretion in Type 2 Diabetes Mellitus Patients with Nephropathy2015
- Author(s)
  Shankhajit De, Shoji Kuwahara, Michihiro Hosojima, MD, PhD, Tomomi Ishikawa, MD, Ryohei Kaseda, MD, PhD, Yusuke Yoshioka, PhD, Yoshiki Suzuki, Ichiei Narita, MD, PhD, Takahiro Ochiya, PhD, Akihiko Saito, MD, PhD.
- Organizer
  American Society of Nephrology 48th Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860630

1. SAITO Akihiko (80293207)

# of Collaborated Projects: 8 results

# of Collaborated Products: 8 results
2. KUWAHARA Shoji (70645209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. KABASAWA Hideyuki (20794639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Kaseda Ryohei (20737697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 成田一衛 (20272817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 寺田康彦 (20400640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 後藤佐和子 (10832884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 蒲澤佳子 (70529726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤由美 (30444160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. DE Shankhajit

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 後藤眞

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosojima Michihiro 細島 康宏

Research Projects

Research Products

Co-Researchers

抗刷子縁抗体病の実態調査と病態解明に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

前向きコホート10年追跡による尿細管マーカーのCKD発症・進展予測能の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

メガリンの構造と機能の精密解析に基づく腎臓病の病態解明と診断・治療の新たな創薬

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyzing the Pathophysiological Mechanisms of Nephrotic Syndrome using 23Na-MRI

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Urinary excretion mechanism of a novel urinary biomarker of diabetic kidney disease, extracellular domain type of megalinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of megalin-targeted strategies for diagnosis, prevention, and treatment of chronic kidney disease and acute kidney injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of urinary megalin excretion linked to the pathophysiology of obesity- or metabolic syndrome-related nephropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism underlying urinary excretion of megalin, a novel biomarker of diabetic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The endocytosis receptor megalin: From bench to bedside2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Urinary A- and C-megalin predict progression of diabetic kidney disease : an exploratory retrospective cohort study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exocytosis-Mediated Urinary Full-Length Megalin Excretion is Linked with the Pathogenesis of Diabetic Nephropathy2017

Author(s)

Journal Title

DOI

Data Source

[Patent] シクロデキストリン誘発腎障害の抑制2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 2型糖尿病患者における尿中メガリンの腎予後予測能の検討2022

Author(s)

Organizer

Data Source

[Presentation] 溶血関連腎症におけるメガリンの役割とその治療戦略2022

Author(s)

Hosojima Michihiro 細島康宏